-- dump date 20140619_090513 -- class Genbank::misc_feature -- table misc_feature_note -- id note 910348000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 910348000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 910348000003 putative catalytic residues [active] 910348000004 putative nucleotide binding site [chemical binding]; other site 910348000005 putative aspartate binding site [chemical binding]; other site 910348000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 910348000007 dimer interface [polypeptide binding]; other site 910348000008 putative threonine allosteric regulatory site; other site 910348000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 910348000010 putative threonine allosteric regulatory site; other site 910348000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 910348000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 910348000013 homoserine kinase; Region: thrB; TIGR00191 910348000014 Protein of unknown function; Region: YhfT; pfam10797 910348000015 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 910348000016 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 910348000017 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 910348000018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348000019 catalytic residue [active] 910348000020 hypothetical protein; Validated; Region: PRK02101 910348000021 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 910348000022 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 910348000023 transaldolase-like protein; Provisional; Region: PTZ00411 910348000024 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 910348000025 active site 910348000026 dimer interface [polypeptide binding]; other site 910348000027 catalytic residue [active] 910348000028 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 910348000029 MPT binding site; other site 910348000030 trimer interface [polypeptide binding]; other site 910348000031 hypothetical protein; Provisional; Region: PRK10659 910348000032 hypothetical protein; Provisional; Region: PRK10154 910348000033 chaperone protein DnaJ; Provisional; Region: PRK10767 910348000034 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 910348000035 HSP70 interaction site [polypeptide binding]; other site 910348000036 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 910348000037 substrate binding site [polypeptide binding]; other site 910348000038 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 910348000039 Zn binding sites [ion binding]; other site 910348000040 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 910348000041 dimer interface [polypeptide binding]; other site 910348000042 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 910348000043 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 910348000044 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 910348000045 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 910348000046 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348000047 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 910348000048 putative dimerization interface [polypeptide binding]; other site 910348000049 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348000050 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 910348000051 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 910348000052 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 910348000053 Riboflavin kinase; Region: Flavokinase; smart00904 910348000054 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 910348000055 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 910348000056 HIGH motif; other site 910348000057 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 910348000058 active site 910348000059 KMSKS motif; other site 910348000060 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 910348000061 tRNA binding surface [nucleotide binding]; other site 910348000062 anticodon binding site; other site 910348000063 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 910348000064 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 910348000065 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 910348000066 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 910348000067 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 910348000068 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 910348000069 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 910348000070 active site 910348000071 tetramer interface [polypeptide binding]; other site 910348000072 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 910348000073 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 910348000074 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 910348000075 Carbamoylphosphate synthase small subunit [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarA; COG0505 910348000076 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 910348000077 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 910348000078 catalytic site [active] 910348000079 subunit interface [polypeptide binding]; other site 910348000080 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 910348000081 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 910348000082 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 910348000083 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 910348000084 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 910348000085 ATP-grasp domain; Region: ATP-grasp_4; cl17255 910348000086 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 910348000087 IMP binding site; other site 910348000088 dimer interface [polypeptide binding]; other site 910348000089 interdomain contacts; other site 910348000090 partial ornithine binding site; other site 910348000091 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 910348000092 carnitine operon protein CaiE; Provisional; Region: PRK13627 910348000093 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 910348000094 putative trimer interface [polypeptide binding]; other site 910348000095 putative metal binding site [ion binding]; other site 910348000096 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 910348000097 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 910348000098 substrate binding site [chemical binding]; other site 910348000099 oxyanion hole (OAH) forming residues; other site 910348000100 trimer interface [polypeptide binding]; other site 910348000101 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 910348000102 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 910348000103 acyl-activating enzyme (AAE) consensus motif; other site 910348000104 putative AMP binding site [chemical binding]; other site 910348000105 putative active site [active] 910348000106 putative CoA binding site [chemical binding]; other site 910348000107 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 910348000108 CoA-transferase family III; Region: CoA_transf_3; pfam02515 910348000109 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 910348000110 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 910348000111 active site 910348000112 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 910348000113 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 910348000114 Ligand binding site [chemical binding]; other site 910348000115 Electron transfer flavoprotein domain; Region: ETF; pfam01012 910348000116 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 910348000117 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 910348000118 Ligand binding site [chemical binding]; other site 910348000119 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 910348000120 putative oxidoreductase FixC; Provisional; Region: PRK10157 910348000121 ferredoxin-like protein FixX; Provisional; Region: PRK15449 910348000122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348000123 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 910348000124 putative substrate translocation pore; other site 910348000125 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 910348000126 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 910348000127 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 910348000128 TrkA-N domain; Region: TrkA_N; pfam02254 910348000129 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 910348000130 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 910348000131 folate binding site [chemical binding]; other site 910348000132 NADP+ binding site [chemical binding]; other site 910348000133 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 910348000134 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 910348000135 active site 910348000136 metal binding site [ion binding]; metal-binding site 910348000137 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 910348000138 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 910348000139 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 910348000140 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 910348000141 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 910348000142 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 910348000143 SurA N-terminal domain; Region: SurA_N; pfam09312 910348000144 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 910348000145 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 910348000146 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 910348000147 OstA-like protein; Region: OstA; pfam03968 910348000148 Organic solvent tolerance protein; Region: OstA_C; pfam04453 910348000149 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 910348000150 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 910348000151 putative metal binding site [ion binding]; other site 910348000152 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 910348000153 HSP70 interaction site [polypeptide binding]; other site 910348000154 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 910348000155 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 910348000156 active site 910348000157 ATP-dependent helicase HepA; Validated; Region: PRK04914 910348000158 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 910348000159 ATP binding site [chemical binding]; other site 910348000160 putative Mg++ binding site [ion binding]; other site 910348000161 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 910348000162 nucleotide binding region [chemical binding]; other site 910348000163 ATP-binding site [chemical binding]; other site 910348000164 DNA polymerase type-B family; Region: POLBc; smart00486 910348000165 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 910348000166 active site 910348000167 catalytic site [active] 910348000168 substrate binding site [chemical binding]; other site 910348000169 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 910348000170 active site 910348000171 metal-binding site 910348000172 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 910348000173 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 910348000174 intersubunit interface [polypeptide binding]; other site 910348000175 active site 910348000176 Zn2+ binding site [ion binding]; other site 910348000177 L-arabinose isomerase; Provisional; Region: PRK02929 910348000178 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 910348000179 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 910348000180 trimer interface [polypeptide binding]; other site 910348000181 putative substrate binding site [chemical binding]; other site 910348000182 putative metal binding site [ion binding]; other site 910348000183 ribulokinase; Provisional; Region: PRK04123 910348000184 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 910348000185 N- and C-terminal domain interface [polypeptide binding]; other site 910348000186 active site 910348000187 MgATP binding site [chemical binding]; other site 910348000188 catalytic site [active] 910348000189 metal binding site [ion binding]; metal-binding site 910348000190 carbohydrate binding site [chemical binding]; other site 910348000191 homodimer interface [polypeptide binding]; other site 910348000192 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 910348000193 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 910348000194 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348000195 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348000196 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 910348000197 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 910348000198 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 910348000199 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 910348000200 Walker A/P-loop; other site 910348000201 ATP binding site [chemical binding]; other site 910348000202 Q-loop/lid; other site 910348000203 ABC transporter signature motif; other site 910348000204 Walker B; other site 910348000205 D-loop; other site 910348000206 H-loop/switch region; other site 910348000207 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 910348000208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348000209 dimer interface [polypeptide binding]; other site 910348000210 conserved gate region; other site 910348000211 putative PBP binding loops; other site 910348000212 ABC-ATPase subunit interface; other site 910348000213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348000214 dimer interface [polypeptide binding]; other site 910348000215 conserved gate region; other site 910348000216 putative PBP binding loops; other site 910348000217 ABC-ATPase subunit interface; other site 910348000218 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 910348000219 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 910348000220 transcriptional regulator SgrR; Provisional; Region: PRK13626 910348000221 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 910348000222 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 910348000223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348000224 sugar efflux transporter; Region: 2A0120; TIGR00899 910348000225 putative substrate translocation pore; other site 910348000226 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 910348000227 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 910348000228 substrate binding site [chemical binding]; other site 910348000229 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 910348000230 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 910348000231 substrate binding site [chemical binding]; other site 910348000232 ligand binding site [chemical binding]; other site 910348000233 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 910348000234 tartrate dehydrogenase; Region: TTC; TIGR02089 910348000235 2-isopropylmalate synthase; Validated; Region: PRK00915 910348000236 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 910348000237 active site 910348000238 catalytic residues [active] 910348000239 metal binding site [ion binding]; metal-binding site 910348000240 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 910348000241 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 910348000242 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348000243 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 910348000244 putative substrate binding pocket [chemical binding]; other site 910348000245 putative dimerization interface [polypeptide binding]; other site 910348000246 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 910348000247 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 910348000248 PYR/PP interface [polypeptide binding]; other site 910348000249 dimer interface [polypeptide binding]; other site 910348000250 TPP binding site [chemical binding]; other site 910348000251 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 910348000252 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 910348000253 TPP-binding site [chemical binding]; other site 910348000254 dimer interface [polypeptide binding]; other site 910348000255 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 910348000256 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 910348000257 putative valine binding site [chemical binding]; other site 910348000258 dimer interface [polypeptide binding]; other site 910348000259 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 910348000260 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 910348000261 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 910348000262 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 910348000263 dimerization interface [polypeptide binding]; other site 910348000264 ligand binding site [chemical binding]; other site 910348000265 mraZ protein; Region: TIGR00242 910348000266 MraZ protein; Region: MraZ; pfam02381 910348000267 MraZ protein; Region: MraZ; pfam02381 910348000268 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 910348000269 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 910348000270 cell division protein FtsL; Provisional; Region: PRK10772 910348000271 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 910348000272 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 910348000273 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 910348000274 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 910348000275 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 910348000276 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 910348000277 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 910348000278 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 910348000279 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 910348000280 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 910348000281 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 910348000282 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 910348000283 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 910348000284 Mg++ binding site [ion binding]; other site 910348000285 putative catalytic motif [active] 910348000286 putative substrate binding site [chemical binding]; other site 910348000287 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 910348000288 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 910348000289 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 910348000290 cell division protein FtsW; Provisional; Region: PRK10774 910348000291 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 910348000292 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 910348000293 active site 910348000294 homodimer interface [polypeptide binding]; other site 910348000295 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 910348000296 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 910348000297 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 910348000298 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 910348000299 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 910348000300 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 910348000301 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 910348000302 cell division protein FtsQ; Provisional; Region: PRK10775 910348000303 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 910348000304 Cell division protein FtsQ; Region: FtsQ; pfam03799 910348000305 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 910348000306 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 910348000307 Cell division protein FtsA; Region: FtsA; pfam14450 910348000308 cell division protein FtsZ; Validated; Region: PRK09330 910348000309 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 910348000310 nucleotide binding site [chemical binding]; other site 910348000311 SulA interaction site; other site 910348000312 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 910348000313 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 910348000314 SecA regulator SecM; Provisional; Region: PRK02943 910348000315 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 910348000316 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 910348000317 SEC-C motif; Region: SEC-C; pfam02810 910348000318 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 910348000319 active site 910348000320 8-oxo-dGMP binding site [chemical binding]; other site 910348000321 nudix motif; other site 910348000322 metal binding site [ion binding]; metal-binding site 910348000323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 910348000324 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 910348000325 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 910348000326 CoA-binding site [chemical binding]; other site 910348000327 ATP-binding [chemical binding]; other site 910348000328 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 910348000329 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 910348000330 active site 910348000331 type IV pilin biogenesis protein; Provisional; Region: PRK10573 910348000332 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 910348000333 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 910348000334 hypothetical protein; Provisional; Region: PRK10436 910348000335 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 910348000336 Walker A motif; other site 910348000337 ATP binding site [chemical binding]; other site 910348000338 Walker B motif; other site 910348000339 putative major pilin subunit; Provisional; Region: PRK10574 910348000340 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 910348000341 Pilin (bacterial filament); Region: Pilin; pfam00114 910348000342 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 910348000343 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 910348000344 dimerization interface [polypeptide binding]; other site 910348000345 active site 910348000346 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 910348000347 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 910348000348 amidase catalytic site [active] 910348000349 Zn binding residues [ion binding]; other site 910348000350 substrate binding site [chemical binding]; other site 910348000351 regulatory protein AmpE; Provisional; Region: PRK10987 910348000352 aromatic amino acid transporter; Provisional; Region: PRK10238 910348000353 Transcriptional regulators [Transcription]; Region: FadR; COG2186 910348000354 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 910348000355 DNA-binding site [nucleotide binding]; DNA binding site 910348000356 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 910348000357 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 910348000358 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 910348000359 dimer interface [polypeptide binding]; other site 910348000360 TPP-binding site [chemical binding]; other site 910348000361 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 910348000362 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 910348000363 E3 interaction surface; other site 910348000364 lipoyl attachment site [posttranslational modification]; other site 910348000365 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 910348000366 E3 interaction surface; other site 910348000367 lipoyl attachment site [posttranslational modification]; other site 910348000368 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 910348000369 E3 interaction surface; other site 910348000370 lipoyl attachment site [posttranslational modification]; other site 910348000371 e3 binding domain; Region: E3_binding; pfam02817 910348000372 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 910348000373 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 910348000374 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 910348000375 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 910348000376 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 910348000377 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 910348000378 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 910348000379 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 910348000380 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 910348000381 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 910348000382 substrate binding site [chemical binding]; other site 910348000383 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 910348000384 substrate binding site [chemical binding]; other site 910348000385 ligand binding site [chemical binding]; other site 910348000386 hypothetical protein; Provisional; Region: PRK05248 910348000387 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 910348000388 spermidine synthase; Provisional; Region: PRK00811 910348000389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348000390 S-adenosylmethionine binding site [chemical binding]; other site 910348000391 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 910348000392 multicopper oxidase; Provisional; Region: PRK10965 910348000393 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 910348000394 Multicopper oxidase; Region: Cu-oxidase; pfam00394 910348000395 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 910348000396 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 910348000397 active site 910348000398 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 910348000399 active site clefts [active] 910348000400 zinc binding site [ion binding]; other site 910348000401 dimer interface [polypeptide binding]; other site 910348000402 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 910348000403 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 910348000404 Walker A/P-loop; other site 910348000405 ATP binding site [chemical binding]; other site 910348000406 Q-loop/lid; other site 910348000407 ABC transporter signature motif; other site 910348000408 Walker B; other site 910348000409 D-loop; other site 910348000410 H-loop/switch region; other site 910348000411 inner membrane transport permease; Provisional; Region: PRK15066 910348000412 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 910348000413 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 910348000414 active pocket/dimerization site; other site 910348000415 active site 910348000416 phosphorylation site [posttranslational modification] 910348000417 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 910348000418 putative active site [active] 910348000419 putative metal binding site [ion binding]; other site 910348000420 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 910348000421 tetramerization interface [polypeptide binding]; other site 910348000422 active site 910348000423 Uncharacterized conserved protein [Function unknown]; Region: COG5464 910348000424 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 910348000425 pantoate--beta-alanine ligase; Region: panC; TIGR00018 910348000426 Pantoate-beta-alanine ligase; Region: PanC; cd00560 910348000427 active site 910348000428 ATP-binding site [chemical binding]; other site 910348000429 pantoate-binding site; other site 910348000430 HXXH motif; other site 910348000431 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 910348000432 oligomerization interface [polypeptide binding]; other site 910348000433 active site 910348000434 metal binding site [ion binding]; metal-binding site 910348000435 Transposase; Region: HTH_Tnp_1; cl17663 910348000436 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 910348000437 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 910348000438 Fimbrial protein; Region: Fimbrial; cl01416 910348000439 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 910348000440 catalytic center binding site [active] 910348000441 ATP binding site [chemical binding]; other site 910348000442 poly(A) polymerase; Region: pcnB; TIGR01942 910348000443 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 910348000444 active site 910348000445 NTP binding site [chemical binding]; other site 910348000446 metal binding triad [ion binding]; metal-binding site 910348000447 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 910348000448 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 910348000449 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 910348000450 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 910348000451 active site 910348000452 nucleotide binding site [chemical binding]; other site 910348000453 HIGH motif; other site 910348000454 KMSKS motif; other site 910348000455 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 910348000456 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 910348000457 2'-5' RNA ligase; Provisional; Region: PRK15124 910348000458 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 910348000459 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 910348000460 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 910348000461 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 910348000462 putative Mg++ binding site [ion binding]; other site 910348000463 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 910348000464 nucleotide binding region [chemical binding]; other site 910348000465 ATP-binding site [chemical binding]; other site 910348000466 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 910348000467 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 910348000468 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 910348000469 Transglycosylase; Region: Transgly; pfam00912 910348000470 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 910348000471 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 910348000472 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 910348000473 N-terminal plug; other site 910348000474 ligand-binding site [chemical binding]; other site 910348000475 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 910348000476 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 910348000477 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 910348000478 Walker A/P-loop; other site 910348000479 ATP binding site [chemical binding]; other site 910348000480 Q-loop/lid; other site 910348000481 ABC transporter signature motif; other site 910348000482 Walker B; other site 910348000483 D-loop; other site 910348000484 H-loop/switch region; other site 910348000485 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 910348000486 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 910348000487 siderophore binding site; other site 910348000488 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 910348000489 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 910348000490 dimer interface [polypeptide binding]; other site 910348000491 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 910348000492 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 910348000493 ABC-ATPase subunit interface; other site 910348000494 dimer interface [polypeptide binding]; other site 910348000495 putative PBP binding regions; other site 910348000496 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 910348000497 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 910348000498 inhibitor-cofactor binding pocket; inhibition site 910348000499 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348000500 catalytic residue [active] 910348000501 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 910348000502 hypothetical protein; Provisional; Region: PRK10578 910348000503 UPF0126 domain; Region: UPF0126; pfam03458 910348000504 UPF0126 domain; Region: UPF0126; pfam03458 910348000505 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 910348000506 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 910348000507 cobalamin binding residues [chemical binding]; other site 910348000508 putative BtuC binding residues; other site 910348000509 dimer interface [polypeptide binding]; other site 910348000510 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 910348000511 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 910348000512 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 910348000513 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 910348000514 Zn2+ binding site [ion binding]; other site 910348000515 Mg2+ binding site [ion binding]; other site 910348000516 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 910348000517 serine endoprotease; Provisional; Region: PRK10942 910348000518 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 910348000519 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 910348000520 protein binding site [polypeptide binding]; other site 910348000521 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 910348000522 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 910348000523 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 910348000524 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 910348000525 hypothetical protein; Provisional; Region: PRK13677 910348000526 phosphodiesterase YaeI; Provisional; Region: PRK11340 910348000527 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 910348000528 putative active site [active] 910348000529 putative metal binding site [ion binding]; other site 910348000530 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 910348000531 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 910348000532 trimer interface [polypeptide binding]; other site 910348000533 active site 910348000534 substrate binding site [chemical binding]; other site 910348000535 CoA binding site [chemical binding]; other site 910348000536 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 910348000537 active site 910348000538 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 910348000539 rRNA interaction site [nucleotide binding]; other site 910348000540 S8 interaction site; other site 910348000541 putative laminin-1 binding site; other site 910348000542 elongation factor Ts; Provisional; Region: tsf; PRK09377 910348000543 UBA/TS-N domain; Region: UBA; pfam00627 910348000544 Elongation factor TS; Region: EF_TS; pfam00889 910348000545 Elongation factor TS; Region: EF_TS; pfam00889 910348000546 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 910348000547 putative nucleotide binding site [chemical binding]; other site 910348000548 uridine monophosphate binding site [chemical binding]; other site 910348000549 homohexameric interface [polypeptide binding]; other site 910348000550 ribosome recycling factor; Reviewed; Region: frr; PRK00083 910348000551 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 910348000552 hinge region; other site 910348000553 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 910348000554 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 910348000555 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 910348000556 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 910348000557 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 910348000558 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 910348000559 catalytic residue [active] 910348000560 putative FPP diphosphate binding site; other site 910348000561 putative FPP binding hydrophobic cleft; other site 910348000562 dimer interface [polypeptide binding]; other site 910348000563 putative IPP diphosphate binding site; other site 910348000564 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 910348000565 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 910348000566 zinc metallopeptidase RseP; Provisional; Region: PRK10779 910348000567 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 910348000568 active site 910348000569 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 910348000570 protein binding site [polypeptide binding]; other site 910348000571 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 910348000572 putative substrate binding region [chemical binding]; other site 910348000573 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 910348000574 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 910348000575 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 910348000576 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 910348000577 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 910348000578 Surface antigen; Region: Bac_surface_Ag; pfam01103 910348000579 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 910348000580 periplasmic chaperone; Provisional; Region: PRK10780 910348000581 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 910348000582 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 910348000583 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 910348000584 trimer interface [polypeptide binding]; other site 910348000585 active site 910348000586 UDP-GlcNAc binding site [chemical binding]; other site 910348000587 lipid binding site [chemical binding]; lipid-binding site 910348000588 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 910348000589 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 910348000590 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 910348000591 active site 910348000592 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 910348000593 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 910348000594 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 910348000595 RNA/DNA hybrid binding site [nucleotide binding]; other site 910348000596 active site 910348000597 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 910348000598 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 910348000599 putative active site [active] 910348000600 putative PHP Thumb interface [polypeptide binding]; other site 910348000601 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 910348000602 generic binding surface II; other site 910348000603 generic binding surface I; other site 910348000604 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 910348000605 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 910348000606 lysine decarboxylase LdcC; Provisional; Region: PRK15399 910348000607 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 910348000608 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 910348000609 homodimer interface [polypeptide binding]; other site 910348000610 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348000611 catalytic residue [active] 910348000612 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 910348000613 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 910348000614 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 910348000615 putative metal binding site [ion binding]; other site 910348000616 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 910348000617 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 910348000618 Ligand Binding Site [chemical binding]; other site 910348000619 TilS substrate binding domain; Region: TilS; pfam09179 910348000620 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 910348000621 Rho-binding antiterminator; Provisional; Region: PRK11625 910348000622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 910348000623 hypothetical protein; Provisional; Region: PRK09256 910348000624 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 910348000625 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 910348000626 NlpE N-terminal domain; Region: NlpE; pfam04170 910348000627 hypothetical protein; Provisional; Region: PRK11479 910348000628 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 910348000629 NlpC/P60 family; Region: NLPC_P60; cl17555 910348000630 prolyl-tRNA synthetase; Provisional; Region: PRK09194 910348000631 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 910348000632 dimer interface [polypeptide binding]; other site 910348000633 motif 1; other site 910348000634 active site 910348000635 motif 2; other site 910348000636 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 910348000637 putative deacylase active site [active] 910348000638 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 910348000639 active site 910348000640 motif 3; other site 910348000641 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 910348000642 anticodon binding site; other site 910348000643 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 910348000644 homodimer interaction site [polypeptide binding]; other site 910348000645 cofactor binding site; other site 910348000646 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 910348000647 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 910348000648 lipoprotein, YaeC family; Region: TIGR00363 910348000649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348000650 dimer interface [polypeptide binding]; other site 910348000651 conserved gate region; other site 910348000652 ABC-ATPase subunit interface; other site 910348000653 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 910348000654 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 910348000655 Walker A/P-loop; other site 910348000656 ATP binding site [chemical binding]; other site 910348000657 Q-loop/lid; other site 910348000658 ABC transporter signature motif; other site 910348000659 Walker B; other site 910348000660 D-loop; other site 910348000661 H-loop/switch region; other site 910348000662 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 910348000663 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 910348000664 motif II; other site 910348000665 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 910348000666 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 910348000667 active site 910348000668 catalytic tetrad [active] 910348000669 Transcriptional regulator [Transcription]; Region: LysR; COG0583 910348000670 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348000671 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 910348000672 putative effector binding pocket; other site 910348000673 dimerization interface [polypeptide binding]; other site 910348000674 hypothetical protein; Provisional; Region: PRK05421 910348000675 putative catalytic site [active] 910348000676 putative metal binding site [ion binding]; other site 910348000677 putative phosphate binding site [ion binding]; other site 910348000678 putative catalytic site [active] 910348000679 putative phosphate binding site [ion binding]; other site 910348000680 putative metal binding site [ion binding]; other site 910348000681 Methyltransferase domain; Region: Methyltransf_31; pfam13847 910348000682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348000683 S-adenosylmethionine binding site [chemical binding]; other site 910348000684 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 910348000685 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 910348000686 N-acetyl-D-glucosamine binding site [chemical binding]; other site 910348000687 catalytic residue [active] 910348000688 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 910348000689 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 910348000690 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 910348000691 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348000692 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 910348000693 RNA/DNA hybrid binding site [nucleotide binding]; other site 910348000694 active site 910348000695 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 910348000696 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 910348000697 active site 910348000698 catalytic site [active] 910348000699 substrate binding site [chemical binding]; other site 910348000700 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348000701 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 910348000702 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 910348000703 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 910348000704 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 910348000705 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 910348000706 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 910348000707 RHS protein; Region: RHS; pfam03527 910348000708 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 910348000709 C-N hydrolase family amidase; Provisional; Region: PRK10438 910348000710 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 910348000711 putative active site [active] 910348000712 catalytic triad [active] 910348000713 dimer interface [polypeptide binding]; other site 910348000714 multimer interface [polypeptide binding]; other site 910348000715 C-lysozyme inhibitor; Provisional; Region: PRK09993 910348000716 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 910348000717 dimer interface [polypeptide binding]; other site 910348000718 active site 910348000719 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 910348000720 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 910348000721 putative active site [active] 910348000722 putative dimer interface [polypeptide binding]; other site 910348000723 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 910348000724 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 910348000725 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 910348000726 NlpC/P60 family; Region: NLPC_P60; pfam00877 910348000727 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 910348000728 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 910348000729 FHIPEP family; Region: FHIPEP; pfam00771 910348000730 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 910348000731 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 910348000732 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 910348000733 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 910348000734 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 910348000735 flagellar motor switch protein FliN; Region: fliN; TIGR02480 910348000736 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 910348000737 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 910348000738 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348000739 Walker A motif; other site 910348000740 ATP binding site [chemical binding]; other site 910348000741 Walker B motif; other site 910348000742 arginine finger; other site 910348000743 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 910348000744 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 910348000745 flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193 910348000746 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 910348000747 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 910348000748 flagellar motor switch protein G; Reviewed; Region: fliG; PRK07194 910348000749 MgtE intracellular N domain; Region: MgtE_N; smart00924 910348000750 FliG C-terminal domain; Region: FliG_C; pfam01706 910348000751 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 910348000752 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 910348000753 Flagellar assembly protein FliH; Region: FliH; pfam02108 910348000754 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 910348000755 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 910348000756 Walker A motif/ATP binding site; other site 910348000757 Walker B motif; other site 910348000758 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 910348000759 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 910348000760 active site 910348000761 nucleotide binding site [chemical binding]; other site 910348000762 HIGH motif; other site 910348000763 KMSKS motif; other site 910348000764 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 910348000765 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 910348000766 active site 910348000767 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 910348000768 FlgN protein; Region: FlgN; pfam05130 910348000769 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 910348000770 SAF-like; Region: SAF_2; pfam13144 910348000771 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 910348000772 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 910348000773 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 910348000774 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK12685 910348000775 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK06802 910348000776 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 910348000777 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 910348000778 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 910348000779 flagellar hook protein FlgE; Validated; Region: flgE; PRK06803 910348000780 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 910348000781 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 910348000782 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 910348000783 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 910348000784 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 910348000785 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 910348000786 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 910348000787 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 910348000788 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12407 910348000789 Flagellar L-ring protein; Region: FlgH; pfam02107 910348000790 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 910348000791 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 910348000792 Rod binding protein; Region: Rod-binding; cl01626 910348000793 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191 910348000794 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 910348000795 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192 910348000796 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 910348000797 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 910348000798 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 910348000799 DNA binding site [nucleotide binding] 910348000800 flagellin; Reviewed; Region: PRK08869 910348000801 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 910348000802 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 910348000803 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 910348000804 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 910348000805 Flagellar protein FliS; Region: FliS; cl00654 910348000806 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 910348000807 adenylate kinase; Region: PLN02674 910348000808 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 910348000809 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 910348000810 flagellar biosynthesis sigma factor; Provisional; Region: PRK12427 910348000811 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 910348000812 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 910348000813 DNA binding residues [nucleotide binding] 910348000814 flagellar motor protein MotA; Provisional; Region: PRK12482 910348000815 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 910348000816 hypothetical protein; Validated; Region: PRK06778 910348000817 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 910348000818 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 910348000819 ligand binding site [chemical binding]; other site 910348000820 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 910348000821 active site 910348000822 DNA polymerase IV; Validated; Region: PRK02406 910348000823 DNA binding site [nucleotide binding] 910348000824 putative antitoxin of the YafO-YafN toxin-antitoxin system; Provisional; Region: PRK09778 910348000825 putative toxin YafO; Provisional; Region: PRK09885 910348000826 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 910348000827 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 910348000828 Coenzyme A binding pocket [chemical binding]; other site 910348000829 RF-1 domain; Region: RF-1; cl17422 910348000830 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 910348000831 metal binding site [ion binding]; metal-binding site 910348000832 dimer interface [polypeptide binding]; other site 910348000833 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 910348000834 active site 910348000835 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 910348000836 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 910348000837 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 910348000838 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 910348000839 trimer interface [polypeptide binding]; other site 910348000840 eyelet of channel; other site 910348000841 gamma-glutamyl kinase; Provisional; Region: PRK05429 910348000842 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 910348000843 nucleotide binding site [chemical binding]; other site 910348000844 homotetrameric interface [polypeptide binding]; other site 910348000845 putative phosphate binding site [ion binding]; other site 910348000846 putative allosteric binding site; other site 910348000847 PUA domain; Region: PUA; pfam01472 910348000848 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 910348000849 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 910348000850 putative catalytic cysteine [active] 910348000851 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 910348000852 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 910348000853 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 910348000854 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 910348000855 MPN+ (JAMM) motif; other site 910348000856 Zinc-binding site [ion binding]; other site 910348000857 Antirestriction protein; Region: Antirestrict; pfam03230 910348000858 Predicted transcriptional regulator [Transcription]; Region: COG2378 910348000859 Predicted transcriptional regulator [Transcription]; Region: COG2378 910348000860 HTH domain; Region: HTH_11; cl17392 910348000861 WYL domain; Region: WYL; pfam13280 910348000862 Domain of unknown function (DUF932); Region: DUF932; pfam06067 910348000863 Predicted GTPase [General function prediction only]; Region: COG3596 910348000864 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 910348000865 YfjP GTPase; Region: YfjP; cd11383 910348000866 G1 box; other site 910348000867 Walker A/P-loop; other site 910348000868 GTP/Mg2+ binding site [chemical binding]; other site 910348000869 ATP binding site [chemical binding]; other site 910348000870 Switch I region; other site 910348000871 G2 box; other site 910348000872 Switch II region; other site 910348000873 G3 box; other site 910348000874 G4 box; other site 910348000875 G5 box; other site 910348000876 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 910348000877 Protein of unknown function (DUF 659); Region: DUF659; pfam04937 910348000878 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 910348000879 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 910348000880 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 910348000881 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 910348000882 protein binding site [polypeptide binding]; other site 910348000883 Peptidase family M48; Region: Peptidase_M48; cl12018 910348000884 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 910348000885 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 910348000886 TrkA-N domain; Region: TrkA_N; pfam02254 910348000887 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 910348000888 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 910348000889 catalytic residues [active] 910348000890 YfdX protein; Region: YfdX; pfam10938 910348000891 YfdX protein; Region: YfdX; pfam10938 910348000892 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 910348000893 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 910348000894 putative dimer interface [polypeptide binding]; other site 910348000895 FtsH Extracellular; Region: FtsH_ext; pfam06480 910348000896 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 910348000897 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348000898 Walker A motif; other site 910348000899 ATP binding site [chemical binding]; other site 910348000900 arginine finger; other site 910348000901 Peptidase family M41; Region: Peptidase_M41; pfam01434 910348000902 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 910348000903 Clp amino terminal domain; Region: Clp_N; pfam02861 910348000904 Clp amino terminal domain; Region: Clp_N; pfam02861 910348000905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348000906 Walker A motif; other site 910348000907 ATP binding site [chemical binding]; other site 910348000908 Walker B motif; other site 910348000909 arginine finger; other site 910348000910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348000911 Walker A motif; other site 910348000912 ATP binding site [chemical binding]; other site 910348000913 Walker B motif; other site 910348000914 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 910348000915 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 910348000916 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 910348000917 putative dimer interface [polypeptide binding]; other site 910348000918 Helix-turn-helix domain; Region: HTH_17; pfam12728 910348000919 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 910348000920 MULE transposase domain; Region: MULE; pfam10551 910348000921 Integrase core domain; Region: rve_3; pfam13683 910348000922 putative transposase OrfB; Reviewed; Region: PHA02517 910348000923 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 910348000924 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 910348000925 putative active site [active] 910348000926 putative NTP binding site [chemical binding]; other site 910348000927 putative nucleic acid binding site [nucleotide binding]; other site 910348000928 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 910348000929 HTH-like domain; Region: HTH_21; pfam13276 910348000930 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 910348000931 Helix-turn-helix domain; Region: HTH_38; pfam13936 910348000932 Integrase core domain; Region: rve; pfam00665 910348000933 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 910348000934 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 910348000935 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 910348000936 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 910348000937 putative active site [active] 910348000938 Fe(II) binding site [ion binding]; other site 910348000939 putative dimer interface [polypeptide binding]; other site 910348000940 putative tetramer interface [polypeptide binding]; other site 910348000941 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 910348000942 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 910348000943 acetaldehyde dehydrogenase; Validated; Region: PRK08300 910348000944 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 910348000945 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 910348000946 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 910348000947 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 910348000948 active site 910348000949 catalytic residues [active] 910348000950 metal binding site [ion binding]; metal-binding site 910348000951 DmpG-like communication domain; Region: DmpG_comm; pfam07836 910348000952 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 910348000953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348000954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348000955 S-methylmethionine transporter; Provisional; Region: PRK11387 910348000956 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 910348000957 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 910348000958 ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432 910348000959 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 910348000960 Walker A/P-loop; other site 910348000961 ATP binding site [chemical binding]; other site 910348000962 Q-loop/lid; other site 910348000963 ABC transporter signature motif; other site 910348000964 Walker B; other site 910348000965 D-loop; other site 910348000966 H-loop/switch region; other site 910348000967 TOBE domain; Region: TOBE_2; pfam08402 910348000968 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348000969 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 910348000970 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 910348000971 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 910348000972 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 910348000973 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348000974 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 910348000975 Predicted membrane protein [Function unknown]; Region: COG3059 910348000976 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 910348000977 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 910348000978 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 910348000979 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 910348000980 Cupin; Region: Cupin_6; pfam12852 910348000981 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 910348000982 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348000983 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 910348000984 Cysteine-rich domain; Region: CCG; pfam02754 910348000985 Cysteine-rich domain; Region: CCG; pfam02754 910348000986 iron-sulfur cluster-binding protein; Region: TIGR00273 910348000987 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 910348000988 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 910348000989 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 910348000990 Uncharacterized conserved protein [Function unknown]; Region: COG1556 910348000991 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 910348000992 choline dehydrogenase; Validated; Region: PRK02106 910348000993 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 910348000994 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 910348000995 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 910348000996 tetrameric interface [polypeptide binding]; other site 910348000997 NAD binding site [chemical binding]; other site 910348000998 catalytic residues [active] 910348000999 transcriptional regulator BetI; Validated; Region: PRK00767 910348001000 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 910348001001 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 910348001002 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 910348001003 DNA binding residues [nucleotide binding] 910348001004 dimerization interface [polypeptide binding]; other site 910348001005 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 910348001006 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 910348001007 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348001008 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 910348001009 dimerization interface [polypeptide binding]; other site 910348001010 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 910348001011 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 910348001012 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 910348001013 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 910348001014 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 910348001015 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 910348001016 CoA binding domain; Region: CoA_binding; pfam02629 910348001017 CoA-ligase; Region: Ligase_CoA; pfam00549 910348001018 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 910348001019 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 910348001020 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 910348001021 putative substrate binding site [chemical binding]; other site 910348001022 nucleotide binding site [chemical binding]; other site 910348001023 nucleotide binding site [chemical binding]; other site 910348001024 homodimer interface [polypeptide binding]; other site 910348001025 putative deaminase; Validated; Region: PRK06846 910348001026 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 910348001027 active site 910348001028 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 910348001029 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 910348001030 putative NAD(P) binding site [chemical binding]; other site 910348001031 putative substrate binding site [chemical binding]; other site 910348001032 catalytic Zn binding site [ion binding]; other site 910348001033 structural Zn binding site [ion binding]; other site 910348001034 dimer interface [polypeptide binding]; other site 910348001035 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 910348001036 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 910348001037 Propionate catabolism activator; Region: PrpR_N; pfam06506 910348001038 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348001039 Walker A motif; other site 910348001040 ATP binding site [chemical binding]; other site 910348001041 Walker B motif; other site 910348001042 arginine finger; other site 910348001043 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 910348001044 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 910348001045 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 910348001046 tetramer interface [polypeptide binding]; other site 910348001047 active site 910348001048 Mg2+/Mn2+ binding site [ion binding]; other site 910348001049 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 910348001050 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 910348001051 dimer interface [polypeptide binding]; other site 910348001052 active site 910348001053 citrylCoA binding site [chemical binding]; other site 910348001054 oxalacetate/citrate binding site [chemical binding]; other site 910348001055 coenzyme A binding site [chemical binding]; other site 910348001056 catalytic triad [active] 910348001057 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 910348001058 2-methylcitrate dehydratase; Region: prpD; TIGR02330 910348001059 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 910348001060 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 910348001061 acyl-activating enzyme (AAE) consensus motif; other site 910348001062 putative AMP binding site [chemical binding]; other site 910348001063 putative active site [active] 910348001064 putative CoA binding site [chemical binding]; other site 910348001065 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 910348001066 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 910348001067 Na binding site [ion binding]; other site 910348001068 putative substrate binding site [chemical binding]; other site 910348001069 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 910348001070 cytosine deaminase; Provisional; Region: PRK09230 910348001071 active site 910348001072 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 910348001073 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348001074 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 910348001075 dimerization interface [polypeptide binding]; other site 910348001076 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 910348001077 active site clefts [active] 910348001078 zinc binding site [ion binding]; other site 910348001079 dimer interface [polypeptide binding]; other site 910348001080 Cyanate lyase [Inorganic ion transport and metabolism]; Region: CynS; COG1513 910348001081 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 910348001082 oligomer interface [polypeptide binding]; other site 910348001083 active site 910348001084 putative cyanate transporter; Provisional; Region: cynX; PRK09705 910348001085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348001086 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 910348001087 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 910348001088 active site 910348001089 substrate binding site [chemical binding]; other site 910348001090 trimer interface [polypeptide binding]; other site 910348001091 CoA binding site [chemical binding]; other site 910348001092 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 910348001093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348001094 putative substrate translocation pore; other site 910348001095 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 910348001096 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 910348001097 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 910348001098 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 910348001099 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 910348001100 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 910348001101 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 910348001102 ligand binding site [chemical binding]; other site 910348001103 dimerization interface (open form) [polypeptide binding]; other site 910348001104 dimerization interface (closed form) [polypeptide binding]; other site 910348001105 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 910348001106 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 910348001107 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 910348001108 Bacterial transcriptional regulator; Region: IclR; pfam01614 910348001109 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 910348001110 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 910348001111 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 910348001112 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 910348001113 putative active site [active] 910348001114 Fe(II) binding site [ion binding]; other site 910348001115 putative dimer interface [polypeptide binding]; other site 910348001116 putative tetramer interface [polypeptide binding]; other site 910348001117 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 910348001118 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 910348001119 2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342 910348001120 acetaldehyde dehydrogenase; Validated; Region: PRK08300 910348001121 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 910348001122 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 910348001123 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 910348001124 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 910348001125 active site 910348001126 catalytic residues [active] 910348001127 metal binding site [ion binding]; metal-binding site 910348001128 DmpG-like communication domain; Region: DmpG_comm; pfam07836 910348001129 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 910348001130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348001131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348001132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 910348001133 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 910348001134 S-formylglutathione hydrolase; Region: PLN02442 910348001135 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 910348001136 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 910348001137 substrate binding site [chemical binding]; other site 910348001138 catalytic Zn binding site [ion binding]; other site 910348001139 NAD binding site [chemical binding]; other site 910348001140 structural Zn binding site [ion binding]; other site 910348001141 dimer interface [polypeptide binding]; other site 910348001142 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 910348001143 putative metal binding site [ion binding]; other site 910348001144 putative homodimer interface [polypeptide binding]; other site 910348001145 putative homotetramer interface [polypeptide binding]; other site 910348001146 putative homodimer-homodimer interface [polypeptide binding]; other site 910348001147 putative allosteric switch controlling residues; other site 910348001148 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348001149 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 910348001150 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 910348001151 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 910348001152 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 910348001153 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 910348001154 substrate binding pocket [chemical binding]; other site 910348001155 membrane-bound complex binding site; other site 910348001156 hinge residues; other site 910348001157 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 910348001158 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 910348001159 Walker A/P-loop; other site 910348001160 ATP binding site [chemical binding]; other site 910348001161 Q-loop/lid; other site 910348001162 ABC transporter signature motif; other site 910348001163 Walker B; other site 910348001164 D-loop; other site 910348001165 H-loop/switch region; other site 910348001166 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 910348001167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348001168 dimer interface [polypeptide binding]; other site 910348001169 conserved gate region; other site 910348001170 putative PBP binding loops; other site 910348001171 ABC-ATPase subunit interface; other site 910348001172 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 910348001173 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 910348001174 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 910348001175 dimer interface [polypeptide binding]; other site 910348001176 active site 910348001177 Schiff base residues; other site 910348001178 Transposase; Region: HTH_Tnp_1; cl17663 910348001179 Integrase core domain; Region: rve; pfam00665 910348001180 Integrase core domain; Region: rve_3; pfam13683 910348001181 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 910348001182 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 910348001183 Autotransporter beta-domain; Region: Autotransporter; pfam03797 910348001184 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 910348001185 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 910348001186 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 910348001187 microcin B17 transporter; Reviewed; Region: PRK11098 910348001188 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 910348001189 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 910348001190 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 910348001191 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 910348001192 anti-RssB factor; Provisional; Region: PRK10244 910348001193 alkaline phosphatase; Provisional; Region: PRK10518 910348001194 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 910348001195 dimer interface [polypeptide binding]; other site 910348001196 active site 910348001197 hypothetical protein; Provisional; Region: PRK11505 910348001198 psiF repeat; Region: PsiF_repeat; pfam07769 910348001199 psiF repeat; Region: PsiF_repeat; pfam07769 910348001200 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 910348001201 MASE2 domain; Region: MASE2; pfam05230 910348001202 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 910348001203 metal binding site [ion binding]; metal-binding site 910348001204 active site 910348001205 I-site; other site 910348001206 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 910348001207 pyrroline-5-carboxylate reductase; Region: PLN02688 910348001208 hypothetical protein; Validated; Region: PRK00124 910348001209 Shikimate kinase; Region: SKI; pfam01202 910348001210 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 910348001211 magnesium binding site [ion binding]; other site 910348001212 putative shikimate binding site; other site 910348001213 hypothetical protein; Provisional; Region: PRK10481 910348001214 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 910348001215 fructokinase; Reviewed; Region: PRK09557 910348001216 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 910348001217 exonuclease subunit SbcC; Provisional; Region: PRK10246 910348001218 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 910348001219 ABC transporter signature motif; other site 910348001220 Walker B; other site 910348001221 D-loop; other site 910348001222 H-loop/switch region; other site 910348001223 exonuclease subunit SbcD; Provisional; Region: PRK10966 910348001224 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 910348001225 active site 910348001226 metal binding site [ion binding]; metal-binding site 910348001227 DNA binding site [nucleotide binding] 910348001228 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 910348001229 transcriptional regulator PhoB; Provisional; Region: PRK10161 910348001230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348001231 active site 910348001232 phosphorylation site [posttranslational modification] 910348001233 intermolecular recognition site; other site 910348001234 dimerization interface [polypeptide binding]; other site 910348001235 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 910348001236 DNA binding site [nucleotide binding] 910348001237 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 910348001238 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 910348001239 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 910348001240 putative active site [active] 910348001241 heme pocket [chemical binding]; other site 910348001242 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 910348001243 dimer interface [polypeptide binding]; other site 910348001244 phosphorylation site [posttranslational modification] 910348001245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348001246 ATP binding site [chemical binding]; other site 910348001247 Mg2+ binding site [ion binding]; other site 910348001248 G-X-G motif; other site 910348001249 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 910348001250 putative proline-specific permease; Provisional; Region: proY; PRK10580 910348001251 Spore germination protein; Region: Spore_permease; cl17796 910348001252 maltodextrin glucosidase; Provisional; Region: PRK10785 910348001253 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 910348001254 homodimer interface [polypeptide binding]; other site 910348001255 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 910348001256 active site 910348001257 homodimer interface [polypeptide binding]; other site 910348001258 catalytic site [active] 910348001259 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 910348001260 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 910348001261 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 910348001262 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 910348001263 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 910348001264 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 910348001265 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 910348001266 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 910348001267 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 910348001268 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 910348001269 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 910348001270 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 910348001271 Protein export membrane protein; Region: SecD_SecF; pfam02355 910348001272 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 910348001273 active site 910348001274 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 910348001275 hypothetical protein; Provisional; Region: PRK11530 910348001276 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 910348001277 ATP cone domain; Region: ATP-cone; pfam03477 910348001278 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 910348001279 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 910348001280 catalytic motif [active] 910348001281 Zn binding site [ion binding]; other site 910348001282 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 910348001283 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 910348001284 homopentamer interface [polypeptide binding]; other site 910348001285 active site 910348001286 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 910348001287 thiamine monophosphate kinase; Provisional; Region: PRK05731 910348001288 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 910348001289 ATP binding site [chemical binding]; other site 910348001290 dimerization interface [polypeptide binding]; other site 910348001291 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 910348001292 tetramer interfaces [polypeptide binding]; other site 910348001293 binuclear metal-binding site [ion binding]; other site 910348001294 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 910348001295 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 910348001296 active site 910348001297 catalytic tetrad [active] 910348001298 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 910348001299 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 910348001300 TPP-binding site; other site 910348001301 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 910348001302 PYR/PP interface [polypeptide binding]; other site 910348001303 dimer interface [polypeptide binding]; other site 910348001304 TPP binding site [chemical binding]; other site 910348001305 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 910348001306 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 910348001307 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 910348001308 substrate binding pocket [chemical binding]; other site 910348001309 chain length determination region; other site 910348001310 substrate-Mg2+ binding site; other site 910348001311 catalytic residues [active] 910348001312 aspartate-rich region 1; other site 910348001313 active site lid residues [active] 910348001314 aspartate-rich region 2; other site 910348001315 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 910348001316 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 910348001317 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 910348001318 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 910348001319 Ligand Binding Site [chemical binding]; other site 910348001320 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 910348001321 active site residue [active] 910348001322 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 910348001323 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 910348001324 conserved cys residue [active] 910348001325 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 910348001326 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 910348001327 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 910348001328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 910348001329 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 910348001330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348001331 Major Facilitator Superfamily; Region: MFS_1; pfam07690 910348001332 putative substrate translocation pore; other site 910348001333 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 910348001334 UbiA prenyltransferase family; Region: UbiA; pfam01040 910348001335 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 910348001336 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 910348001337 Subunit I/III interface [polypeptide binding]; other site 910348001338 Subunit III/IV interface [polypeptide binding]; other site 910348001339 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 910348001340 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 910348001341 D-pathway; other site 910348001342 Putative ubiquinol binding site [chemical binding]; other site 910348001343 Low-spin heme (heme b) binding site [chemical binding]; other site 910348001344 Putative water exit pathway; other site 910348001345 Binuclear center (heme o3/CuB) [ion binding]; other site 910348001346 K-pathway; other site 910348001347 Putative proton exit pathway; other site 910348001348 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 910348001349 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 910348001350 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 910348001351 muropeptide transporter; Reviewed; Region: ampG; PRK11902 910348001352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348001353 putative substrate translocation pore; other site 910348001354 hypothetical protein; Provisional; Region: PRK11627 910348001355 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 910348001356 transcriptional regulator BolA; Provisional; Region: PRK11628 910348001357 trigger factor; Provisional; Region: tig; PRK01490 910348001358 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 910348001359 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 910348001360 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 910348001361 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 910348001362 oligomer interface [polypeptide binding]; other site 910348001363 active site residues [active] 910348001364 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 910348001365 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 910348001366 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 910348001367 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 910348001368 Found in ATP-dependent protease La (LON); Region: LON; smart00464 910348001369 Found in ATP-dependent protease La (LON); Region: LON; smart00464 910348001370 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348001371 Walker A motif; other site 910348001372 ATP binding site [chemical binding]; other site 910348001373 Walker B motif; other site 910348001374 arginine finger; other site 910348001375 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 910348001376 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 910348001377 IHF dimer interface [polypeptide binding]; other site 910348001378 IHF - DNA interface [nucleotide binding]; other site 910348001379 periplasmic folding chaperone; Provisional; Region: PRK10788 910348001380 SurA N-terminal domain; Region: SurA_N_3; cl07813 910348001381 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 910348001382 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 910348001383 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 910348001384 active site 910348001385 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 910348001386 Ligand Binding Site [chemical binding]; other site 910348001387 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 910348001388 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 910348001389 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 910348001390 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 910348001391 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 910348001392 active site 910348001393 motif I; other site 910348001394 motif II; other site 910348001395 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 910348001396 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 910348001397 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 910348001398 Walker A/P-loop; other site 910348001399 ATP binding site [chemical binding]; other site 910348001400 Q-loop/lid; other site 910348001401 ABC transporter signature motif; other site 910348001402 Walker B; other site 910348001403 D-loop; other site 910348001404 H-loop/switch region; other site 910348001405 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 910348001406 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 910348001407 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 910348001408 Walker A/P-loop; other site 910348001409 ATP binding site [chemical binding]; other site 910348001410 Q-loop/lid; other site 910348001411 ABC transporter signature motif; other site 910348001412 Walker B; other site 910348001413 D-loop; other site 910348001414 H-loop/switch region; other site 910348001415 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 910348001416 Nitrogen regulatory protein P-II; Region: P-II; smart00938 910348001417 ammonium transporter; Provisional; Region: PRK10666 910348001418 acyl-CoA thioesterase II; Provisional; Region: PRK10526 910348001419 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 910348001420 active site 910348001421 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 910348001422 catalytic triad [active] 910348001423 dimer interface [polypeptide binding]; other site 910348001424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 910348001425 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 910348001426 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 910348001427 DNA binding site [nucleotide binding] 910348001428 active site 910348001429 Uncharacterized conserved protein [Function unknown]; Region: COG5507 910348001430 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 910348001431 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 910348001432 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 910348001433 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 910348001434 maltose O-acetyltransferase; Provisional; Region: PRK10092 910348001435 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 910348001436 active site 910348001437 substrate binding site [chemical binding]; other site 910348001438 trimer interface [polypeptide binding]; other site 910348001439 CoA binding site [chemical binding]; other site 910348001440 gene expression modulator; Provisional; Region: PRK10945 910348001441 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 910348001442 Protein export membrane protein; Region: SecD_SecF; cl14618 910348001443 Protein export membrane protein; Region: SecD_SecF; cl14618 910348001444 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 910348001445 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 910348001446 HlyD family secretion protein; Region: HlyD_3; pfam13437 910348001447 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 910348001448 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 910348001449 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 910348001450 hypothetical protein; Provisional; Region: PRK11281 910348001451 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 910348001452 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 910348001453 Mechanosensitive ion channel; Region: MS_channel; pfam00924 910348001454 primosomal replication protein N''; Provisional; Region: PRK10093 910348001455 hypothetical protein; Provisional; Region: PRK10527 910348001456 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 910348001457 active site 910348001458 DNA polymerase III subunit delta'; Validated; Region: PRK08485 910348001459 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 910348001460 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 910348001461 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 910348001462 RecR protein; Region: RecR; pfam02132 910348001463 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 910348001464 putative active site [active] 910348001465 putative metal-binding site [ion binding]; other site 910348001466 tetramer interface [polypeptide binding]; other site 910348001467 heat shock protein 90; Provisional; Region: PRK05218 910348001468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348001469 ATP binding site [chemical binding]; other site 910348001470 Mg2+ binding site [ion binding]; other site 910348001471 G-X-G motif; other site 910348001472 adenylate kinase; Reviewed; Region: adk; PRK00279 910348001473 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 910348001474 AMP-binding site [chemical binding]; other site 910348001475 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 910348001476 ferrochelatase; Region: hemH; TIGR00109 910348001477 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 910348001478 C-terminal domain interface [polypeptide binding]; other site 910348001479 active site 910348001480 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 910348001481 active site 910348001482 N-terminal domain interface [polypeptide binding]; other site 910348001483 acetyl esterase; Provisional; Region: PRK10162 910348001484 putative cation:proton antiport protein; Provisional; Region: PRK10669 910348001485 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 910348001486 TrkA-N domain; Region: TrkA_N; pfam02254 910348001487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348001488 Major Facilitator Superfamily; Region: MFS_1; pfam07690 910348001489 putative substrate translocation pore; other site 910348001490 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 910348001491 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 910348001492 active site 910348001493 metal binding site [ion binding]; metal-binding site 910348001494 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 910348001495 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 910348001496 putative deacylase active site [active] 910348001497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 910348001498 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 910348001499 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 910348001500 non-specific DNA binding site [nucleotide binding]; other site 910348001501 salt bridge; other site 910348001502 sequence-specific DNA binding site [nucleotide binding]; other site 910348001503 copper exporting ATPase; Provisional; Region: copA; PRK10671 910348001504 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 910348001505 metal-binding site [ion binding] 910348001506 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 910348001507 metal-binding site [ion binding] 910348001508 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 910348001509 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 910348001510 motif II; other site 910348001511 glutaminase; Reviewed; Region: PRK12356 910348001512 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 910348001513 amino acid transporter; Region: 2A0306; TIGR00909 910348001514 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 910348001515 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 910348001516 DNA binding residues [nucleotide binding] 910348001517 dimer interface [polypeptide binding]; other site 910348001518 copper binding site [ion binding]; other site 910348001519 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 910348001520 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 910348001521 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 910348001522 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 910348001523 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 910348001524 Walker A/P-loop; other site 910348001525 ATP binding site [chemical binding]; other site 910348001526 Q-loop/lid; other site 910348001527 ABC transporter signature motif; other site 910348001528 Walker B; other site 910348001529 D-loop; other site 910348001530 H-loop/switch region; other site 910348001531 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 910348001532 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 910348001533 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 910348001534 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 910348001535 active site 910348001536 catalytic triad [active] 910348001537 oxyanion hole [active] 910348001538 switch loop; other site 910348001539 oxidoreductase; Provisional; Region: PRK08017 910348001540 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 910348001541 NADP binding site [chemical binding]; other site 910348001542 active site 910348001543 steroid binding site; other site 910348001544 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 910348001545 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 910348001546 Walker A/P-loop; other site 910348001547 ATP binding site [chemical binding]; other site 910348001548 Q-loop/lid; other site 910348001549 ABC transporter signature motif; other site 910348001550 Walker B; other site 910348001551 D-loop; other site 910348001552 H-loop/switch region; other site 910348001553 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 910348001554 FtsX-like permease family; Region: FtsX; pfam02687 910348001555 FtsX-like permease family; Region: FtsX; pfam02687 910348001556 PAAR motif; Region: PAAR_motif; cl15808 910348001557 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 910348001558 RHS Repeat; Region: RHS_repeat; pfam05593 910348001559 RHS Repeat; Region: RHS_repeat; pfam05593 910348001560 RHS Repeat; Region: RHS_repeat; pfam05593 910348001561 RHS Repeat; Region: RHS_repeat; pfam05593 910348001562 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 910348001563 RHS Repeat; Region: RHS_repeat; pfam05593 910348001564 RHS Repeat; Region: RHS_repeat; pfam05593 910348001565 RHS protein; Region: RHS; pfam03527 910348001566 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 910348001567 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 910348001568 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 910348001569 RHS protein; Region: RHS; pfam03527 910348001570 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 910348001571 Winged helix-turn helix; Region: HTH_29; pfam13551 910348001572 Helix-turn-helix domain; Region: HTH_28; pfam13518 910348001573 Predicted ATPase [General function prediction only]; Region: COG2603 910348001574 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 910348001575 active site residue [active] 910348001576 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 910348001577 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348001578 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 910348001579 dimerization interface [polypeptide binding]; other site 910348001580 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 910348001581 ureidoglycolate hydrolase; Provisional; Region: PRK03606 910348001582 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 910348001583 Bacterial transcriptional regulator; Region: IclR; pfam01614 910348001584 glyoxylate carboligase; Provisional; Region: PRK11269 910348001585 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 910348001586 PYR/PP interface [polypeptide binding]; other site 910348001587 dimer interface [polypeptide binding]; other site 910348001588 TPP binding site [chemical binding]; other site 910348001589 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 910348001590 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 910348001591 TPP-binding site [chemical binding]; other site 910348001592 hydroxypyruvate isomerase; Provisional; Region: PRK09997 910348001593 tartronate semialdehyde reductase; Provisional; Region: PRK15059 910348001594 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 910348001595 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 910348001596 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348001597 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 910348001598 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 910348001599 substrate binding site [chemical binding]; other site 910348001600 Na binding site [ion binding]; other site 910348001601 allantoinase; Provisional; Region: PRK08044 910348001602 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 910348001603 active site 910348001604 putative uracil/xanthine transporter; Provisional; Region: PRK11412 910348001605 glycerate kinase II; Provisional; Region: PRK09932 910348001606 putative allantoin catabolism protein; Region: ura-cupin; TIGR03214 910348001607 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 910348001608 Cupin domain; Region: Cupin_2; cl17218 910348001609 allantoate amidohydrolase; Region: AllC; TIGR03176 910348001610 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 910348001611 active site 910348001612 metal binding site [ion binding]; metal-binding site 910348001613 dimer interface [polypeptide binding]; other site 910348001614 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 910348001615 membrane protein FdrA; Validated; Region: PRK06091 910348001616 CoA binding domain; Region: CoA_binding; pfam02629 910348001617 CoA-ligase; Region: Ligase_CoA; pfam00549 910348001618 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 910348001619 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 910348001620 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 910348001621 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 910348001622 putative substrate binding site [chemical binding]; other site 910348001623 nucleotide binding site [chemical binding]; other site 910348001624 nucleotide binding site [chemical binding]; other site 910348001625 homodimer interface [polypeptide binding]; other site 910348001626 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 910348001627 ATP-grasp domain; Region: ATP-grasp; pfam02222 910348001628 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 910348001629 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 910348001630 putative active site [active] 910348001631 putative metal binding site [ion binding]; other site 910348001632 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 910348001633 substrate binding site [chemical binding]; other site 910348001634 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 910348001635 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 910348001636 active site 910348001637 HIGH motif; other site 910348001638 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 910348001639 KMSKS motif; other site 910348001640 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 910348001641 tRNA binding surface [nucleotide binding]; other site 910348001642 anticodon binding site; other site 910348001643 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 910348001644 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 910348001645 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 910348001646 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 910348001647 homodimer interface [polypeptide binding]; other site 910348001648 NADP binding site [chemical binding]; other site 910348001649 substrate binding site [chemical binding]; other site 910348001650 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348001651 PapC N-terminal domain; Region: PapC_N; pfam13954 910348001652 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 910348001653 PapC C-terminal domain; Region: PapC_C; pfam13953 910348001654 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 910348001655 Fimbrial protein; Region: Fimbrial; cl01416 910348001656 transcriptional regulator FimZ; Provisional; Region: PRK09935 910348001657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348001658 active site 910348001659 phosphorylation site [posttranslational modification] 910348001660 intermolecular recognition site; other site 910348001661 dimerization interface [polypeptide binding]; other site 910348001662 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 910348001663 DNA binding residues [nucleotide binding] 910348001664 dimerization interface [polypeptide binding]; other site 910348001665 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 910348001666 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348001667 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 910348001668 hypothetical protein; Provisional; Region: PRK09936 910348001669 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 910348001670 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 910348001671 TPR motif; other site 910348001672 binding surface 910348001673 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 910348001674 sensor kinase CusS; Provisional; Region: PRK09835 910348001675 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 910348001676 dimerization interface [polypeptide binding]; other site 910348001677 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 910348001678 dimer interface [polypeptide binding]; other site 910348001679 phosphorylation site [posttranslational modification] 910348001680 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348001681 ATP binding site [chemical binding]; other site 910348001682 Mg2+ binding site [ion binding]; other site 910348001683 G-X-G motif; other site 910348001684 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 910348001685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348001686 active site 910348001687 phosphorylation site [posttranslational modification] 910348001688 intermolecular recognition site; other site 910348001689 dimerization interface [polypeptide binding]; other site 910348001690 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 910348001691 DNA binding site [nucleotide binding] 910348001692 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 910348001693 periplasmic copper-binding protein; Provisional; Region: PRK09838 910348001694 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 910348001695 HlyD family secretion protein; Region: HlyD_3; pfam13437 910348001696 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 910348001697 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 910348001698 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 910348001699 Mechanosensitive ion channel; Region: MS_channel; pfam00924 910348001700 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 910348001701 dimer interface [polypeptide binding]; other site 910348001702 FMN binding site [chemical binding]; other site 910348001703 hypothetical protein; Provisional; Region: PRK10250 910348001704 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 910348001705 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 910348001706 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 910348001707 Hok/gef family; Region: HOK_GEF; pfam01848 910348001708 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 910348001709 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 910348001710 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 910348001711 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 910348001712 outer membrane receptor FepA; Provisional; Region: PRK13524 910348001713 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 910348001714 N-terminal plug; other site 910348001715 ligand-binding site [chemical binding]; other site 910348001716 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 910348001717 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 910348001718 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 910348001719 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 910348001720 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 910348001721 acyl-activating enzyme (AAE) consensus motif; other site 910348001722 AMP binding site [chemical binding]; other site 910348001723 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 910348001724 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 910348001725 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 910348001726 Walker A/P-loop; other site 910348001727 ATP binding site [chemical binding]; other site 910348001728 Q-loop/lid; other site 910348001729 ABC transporter signature motif; other site 910348001730 Walker B; other site 910348001731 D-loop; other site 910348001732 H-loop/switch region; other site 910348001733 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 910348001734 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 910348001735 ABC-ATPase subunit interface; other site 910348001736 dimer interface [polypeptide binding]; other site 910348001737 putative PBP binding regions; other site 910348001738 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 910348001739 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 910348001740 ABC-ATPase subunit interface; other site 910348001741 dimer interface [polypeptide binding]; other site 910348001742 putative PBP binding regions; other site 910348001743 enterobactin exporter EntS; Provisional; Region: PRK10489 910348001744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348001745 putative substrate translocation pore; other site 910348001746 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 910348001747 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 910348001748 siderophore binding site; other site 910348001749 isochorismate synthase EntC; Provisional; Region: PRK15016 910348001750 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 910348001751 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 910348001752 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 910348001753 acyl-activating enzyme (AAE) consensus motif; other site 910348001754 active site 910348001755 AMP binding site [chemical binding]; other site 910348001756 substrate binding site [chemical binding]; other site 910348001757 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 910348001758 hydrophobic substrate binding pocket; other site 910348001759 Isochorismatase family; Region: Isochorismatase; pfam00857 910348001760 active site 910348001761 conserved cis-peptide bond; other site 910348001762 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 910348001763 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 910348001764 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 910348001765 putative NAD(P) binding site [chemical binding]; other site 910348001766 active site 910348001767 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 910348001768 CoenzymeA binding site [chemical binding]; other site 910348001769 subunit interaction site [polypeptide binding]; other site 910348001770 PHB binding site; other site 910348001771 carbon starvation protein A; Provisional; Region: PRK15015 910348001772 Carbon starvation protein CstA; Region: CstA; pfam02554 910348001773 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 910348001774 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 910348001775 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 910348001776 putative active site [active] 910348001777 metal binding site [ion binding]; metal-binding site 910348001778 methionine aminotransferase; Validated; Region: PRK09082 910348001779 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 910348001780 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348001781 homodimer interface [polypeptide binding]; other site 910348001782 catalytic residue [active] 910348001783 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 910348001784 ParB-like nuclease domain; Region: ParBc; pfam02195 910348001785 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 910348001786 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 910348001787 Active Sites [active] 910348001788 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 910348001789 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 910348001790 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348001791 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 910348001792 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 910348001793 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 910348001794 dimerization domain [polypeptide binding]; other site 910348001795 dimer interface [polypeptide binding]; other site 910348001796 catalytic residues [active] 910348001797 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 910348001798 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 910348001799 dimer interface [polypeptide binding]; other site 910348001800 decamer (pentamer of dimers) interface [polypeptide binding]; other site 910348001801 catalytic triad [active] 910348001802 peroxidatic and resolving cysteines [active] 910348001803 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 910348001804 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 910348001805 catalytic residue [active] 910348001806 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 910348001807 catalytic residues [active] 910348001808 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 910348001809 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 910348001810 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 910348001811 Ligand Binding Site [chemical binding]; other site 910348001812 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 910348001813 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 910348001814 NAD binding site [chemical binding]; other site 910348001815 catalytic Zn binding site [ion binding]; other site 910348001816 structural Zn binding site [ion binding]; other site 910348001817 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 910348001818 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 910348001819 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 910348001820 B1 nucleotide binding pocket [chemical binding]; other site 910348001821 B2 nucleotide binding pocket [chemical binding]; other site 910348001822 CAS motifs; other site 910348001823 active site 910348001824 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 910348001825 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 910348001826 transmembrane helices; other site 910348001827 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 910348001828 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 910348001829 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 910348001830 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 910348001831 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 910348001832 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 910348001833 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 910348001834 putative active site [active] 910348001835 (T/H)XGH motif; other site 910348001836 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 910348001837 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 910348001838 putative active site [active] 910348001839 heme pocket [chemical binding]; other site 910348001840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348001841 ATP binding site [chemical binding]; other site 910348001842 Mg2+ binding site [ion binding]; other site 910348001843 G-X-G motif; other site 910348001844 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 910348001845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348001846 active site 910348001847 phosphorylation site [posttranslational modification] 910348001848 intermolecular recognition site; other site 910348001849 dimerization interface [polypeptide binding]; other site 910348001850 Transcriptional regulator; Region: CitT; pfam12431 910348001851 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 910348001852 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 910348001853 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 910348001854 chromosome condensation membrane protein; Provisional; Region: PRK14196 910348001855 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 910348001856 lipoyl synthase; Provisional; Region: PRK05481 910348001857 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 910348001858 FeS/SAM binding site; other site 910348001859 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 910348001860 substrate binding pocket [chemical binding]; other site 910348001861 dimerization interface [polypeptide binding]; other site 910348001862 lipoate-protein ligase B; Provisional; Region: PRK14342 910348001863 hypothetical protein; Provisional; Region: PRK04998 910348001864 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 910348001865 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 910348001866 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 910348001867 rare lipoprotein A; Provisional; Region: PRK10672 910348001868 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 910348001869 Sporulation related domain; Region: SPOR; pfam05036 910348001870 cell wall shape-determining protein; Provisional; Region: PRK10794 910348001871 penicillin-binding protein 2; Provisional; Region: PRK10795 910348001872 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 910348001873 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 910348001874 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 910348001875 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 910348001876 catalytic core [active] 910348001877 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 910348001878 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 910348001879 active site 910348001880 (T/H)XGH motif; other site 910348001881 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 910348001882 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 910348001883 Lipopolysaccharide-assembly; Region: LptE; cl01125 910348001884 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 910348001885 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 910348001886 HIGH motif; other site 910348001887 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 910348001888 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 910348001889 active site 910348001890 KMSKS motif; other site 910348001891 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 910348001892 tRNA binding surface [nucleotide binding]; other site 910348001893 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 910348001894 hypothetical protein; Provisional; Region: PRK11032 910348001895 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 910348001896 Sel1-like repeats; Region: SEL1; smart00671 910348001897 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 910348001898 Sel1-like repeats; Region: SEL1; smart00671 910348001899 Sel1-like repeats; Region: SEL1; smart00671 910348001900 Sel1-like repeats; Region: SEL1; smart00671 910348001901 Sel1-like repeats; Region: SEL1; smart00671 910348001902 Sel1-like repeats; Region: SEL1; smart00671 910348001903 Sel1-like repeats; Region: SEL1; smart00671 910348001904 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 910348001905 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 910348001906 HSP70 interaction site [polypeptide binding]; other site 910348001907 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348001908 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 910348001909 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 910348001910 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 910348001911 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 910348001912 nucleotide binding site [chemical binding]; other site 910348001913 putative NEF/HSP70 interaction site [polypeptide binding]; other site 910348001914 SBD interface [polypeptide binding]; other site 910348001915 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 910348001916 active site 910348001917 tetramer interface [polypeptide binding]; other site 910348001918 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 910348001919 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 910348001920 Walker A/P-loop; other site 910348001921 ATP binding site [chemical binding]; other site 910348001922 Q-loop/lid; other site 910348001923 ABC transporter signature motif; other site 910348001924 Walker B; other site 910348001925 D-loop; other site 910348001926 H-loop/switch region; other site 910348001927 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 910348001928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348001929 dimer interface [polypeptide binding]; other site 910348001930 conserved gate region; other site 910348001931 putative PBP binding loops; other site 910348001932 ABC-ATPase subunit interface; other site 910348001933 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 910348001934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348001935 dimer interface [polypeptide binding]; other site 910348001936 conserved gate region; other site 910348001937 putative PBP binding loops; other site 910348001938 ABC-ATPase subunit interface; other site 910348001939 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 910348001940 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 910348001941 substrate binding pocket [chemical binding]; other site 910348001942 membrane-bound complex binding site; other site 910348001943 hinge residues; other site 910348001944 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 910348001945 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 910348001946 putative active site [active] 910348001947 catalytic triad [active] 910348001948 putative dimer interface [polypeptide binding]; other site 910348001949 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 910348001950 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 910348001951 Transporter associated domain; Region: CorC_HlyC; smart01091 910348001952 metal-binding heat shock protein; Provisional; Region: PRK00016 910348001953 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 910348001954 PhoH-like protein; Region: PhoH; pfam02562 910348001955 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 910348001956 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 910348001957 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 910348001958 FeS/SAM binding site; other site 910348001959 TRAM domain; Region: TRAM; pfam01938 910348001960 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 910348001961 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 910348001962 asparagine synthetase B; Provisional; Region: asnB; PRK09431 910348001963 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 910348001964 active site 910348001965 dimer interface [polypeptide binding]; other site 910348001966 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 910348001967 Ligand Binding Site [chemical binding]; other site 910348001968 Molecular Tunnel; other site 910348001969 UMP phosphatase; Provisional; Region: PRK10444 910348001970 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 910348001971 active site 910348001972 motif I; other site 910348001973 motif II; other site 910348001974 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 910348001975 MarR family; Region: MarR; pfam01047 910348001976 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 910348001977 ROK family; Region: ROK; pfam00480 910348001978 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 910348001979 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 910348001980 active site 910348001981 dimer interface [polypeptide binding]; other site 910348001982 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 910348001983 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 910348001984 active site 910348001985 trimer interface [polypeptide binding]; other site 910348001986 allosteric site; other site 910348001987 active site lid [active] 910348001988 hexamer (dimer of trimers) interface [polypeptide binding]; other site 910348001989 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 910348001990 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 910348001991 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 910348001992 active site turn [active] 910348001993 phosphorylation site [posttranslational modification] 910348001994 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 910348001995 HPr interaction site; other site 910348001996 glycerol kinase (GK) interaction site [polypeptide binding]; other site 910348001997 active site 910348001998 phosphorylation site [posttranslational modification] 910348001999 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 910348002000 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 910348002001 active site 910348002002 HIGH motif; other site 910348002003 nucleotide binding site [chemical binding]; other site 910348002004 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 910348002005 KMSKS motif; other site 910348002006 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 910348002007 outer membrane porin, OprD family; Region: OprD; pfam03573 910348002008 ferric uptake regulator; Provisional; Region: fur; PRK09462 910348002009 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 910348002010 metal binding site 2 [ion binding]; metal-binding site 910348002011 putative DNA binding helix; other site 910348002012 metal binding site 1 [ion binding]; metal-binding site 910348002013 dimer interface [polypeptide binding]; other site 910348002014 structural Zn2+ binding site [ion binding]; other site 910348002015 flavodoxin FldA; Validated; Region: PRK09267 910348002016 LexA regulated protein; Provisional; Region: PRK11675 910348002017 acyl-CoA esterase; Provisional; Region: PRK10673 910348002018 PGAP1-like protein; Region: PGAP1; pfam07819 910348002019 replication initiation regulator SeqA; Provisional; Region: PRK11187 910348002020 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 910348002021 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 910348002022 active site 910348002023 substrate binding site [chemical binding]; other site 910348002024 metal binding site [ion binding]; metal-binding site 910348002025 Protein of unknown function DUF2625; Region: DUF2625; pfam10946 910348002026 putrescine transporter; Provisional; Region: potE; PRK10655 910348002027 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 910348002028 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 910348002029 homodimer interface [polypeptide binding]; other site 910348002030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348002031 catalytic residue [active] 910348002032 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 910348002033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348002034 active site 910348002035 phosphorylation site [posttranslational modification] 910348002036 intermolecular recognition site; other site 910348002037 dimerization interface [polypeptide binding]; other site 910348002038 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 910348002039 DNA binding site [nucleotide binding] 910348002040 sensor protein KdpD; Provisional; Region: PRK10490 910348002041 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 910348002042 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 910348002043 Ligand Binding Site [chemical binding]; other site 910348002044 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 910348002045 GAF domain; Region: GAF_3; pfam13492 910348002046 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 910348002047 dimer interface [polypeptide binding]; other site 910348002048 phosphorylation site [posttranslational modification] 910348002049 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348002050 ATP binding site [chemical binding]; other site 910348002051 Mg2+ binding site [ion binding]; other site 910348002052 G-X-G motif; other site 910348002053 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 910348002054 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 910348002055 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 910348002056 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 910348002057 PAAR motif; Region: PAAR_motif; cl15808 910348002058 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 910348002059 RHS Repeat; Region: RHS_repeat; pfam05593 910348002060 RHS Repeat; Region: RHS_repeat; pfam05593 910348002061 RHS Repeat; Region: RHS_repeat; pfam05593 910348002062 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 910348002063 RHS Repeat; Region: RHS_repeat; pfam05593 910348002064 RHS Repeat; Region: RHS_repeat; pfam05593 910348002065 RHS protein; Region: RHS; pfam03527 910348002066 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 910348002067 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 910348002068 RHS protein; Region: RHS; pfam03527 910348002069 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 910348002070 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 910348002071 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 910348002072 Transposase [DNA replication, recombination, and repair]; Region: COG5433 910348002073 Transposase [DNA replication, recombination, and repair]; Region: COG5433 910348002074 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 910348002075 Transposase [DNA replication, recombination, and repair]; Region: COG5433 910348002076 hypothetical protein; Provisional; Region: PRK10167 910348002077 Uncharacterized conserved protein [Function unknown]; Region: COG3272 910348002078 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 910348002079 DNA photolyase; Region: DNA_photolyase; pfam00875 910348002080 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 910348002081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348002082 putative substrate translocation pore; other site 910348002083 POT family; Region: PTR2; pfam00854 910348002084 Uncharacterized conserved protein [Function unknown]; Region: COG0327 910348002085 metal-binding protein; Provisional; Region: PRK10799 910348002086 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 910348002087 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 910348002088 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 910348002089 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 910348002090 endonuclease VIII; Provisional; Region: PRK10445 910348002091 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 910348002092 DNA binding site [nucleotide binding] 910348002093 catalytic residue [active] 910348002094 putative catalytic residues [active] 910348002095 H2TH interface [polypeptide binding]; other site 910348002096 intercalation triad [nucleotide binding]; other site 910348002097 substrate specificity determining residue; other site 910348002098 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 910348002099 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 910348002100 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 910348002101 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 910348002102 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 910348002103 Fimbrial protein; Region: Fimbrial; pfam00419 910348002104 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 910348002105 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 910348002106 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 910348002107 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 910348002108 PapC N-terminal domain; Region: PapC_N; pfam13954 910348002109 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 910348002110 PapC C-terminal domain; Region: PapC_C; pfam13953 910348002111 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 910348002112 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 910348002113 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 910348002114 dimer interface [polypeptide binding]; other site 910348002115 active site 910348002116 citrylCoA binding site [chemical binding]; other site 910348002117 NADH binding [chemical binding]; other site 910348002118 cationic pore residues; other site 910348002119 oxalacetate/citrate binding site [chemical binding]; other site 910348002120 coenzyme A binding site [chemical binding]; other site 910348002121 catalytic triad [active] 910348002122 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 910348002123 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 910348002124 SdhC subunit interface [polypeptide binding]; other site 910348002125 proximal heme binding site [chemical binding]; other site 910348002126 cardiolipin binding site; other site 910348002127 Iron-sulfur protein interface; other site 910348002128 proximal quinone binding site [chemical binding]; other site 910348002129 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 910348002130 L-aspartate oxidase; Provisional; Region: PRK06175 910348002131 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 910348002132 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 910348002133 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 910348002134 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 910348002135 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 910348002136 TPP-binding site [chemical binding]; other site 910348002137 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 910348002138 dimer interface [polypeptide binding]; other site 910348002139 PYR/PP interface [polypeptide binding]; other site 910348002140 TPP binding site [chemical binding]; other site 910348002141 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 910348002142 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 910348002143 E3 interaction surface; other site 910348002144 lipoyl attachment site [posttranslational modification]; other site 910348002145 e3 binding domain; Region: E3_binding; pfam02817 910348002146 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 910348002147 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 910348002148 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 910348002149 CoA-ligase; Region: Ligase_CoA; pfam00549 910348002150 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 910348002151 CoA binding domain; Region: CoA_binding; smart00881 910348002152 CoA-ligase; Region: Ligase_CoA; pfam00549 910348002153 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 910348002154 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 910348002155 DNA-binding site [nucleotide binding]; DNA binding site 910348002156 UTRA domain; Region: UTRA; pfam07702 910348002157 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 910348002158 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 910348002159 active site 910348002160 phosphorylation site [posttranslational modification] 910348002161 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 910348002162 active site 910348002163 P-loop; other site 910348002164 phosphorylation site [posttranslational modification] 910348002165 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 910348002166 alpha-mannosidase; Provisional; Region: PRK09819 910348002167 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 910348002168 active site 910348002169 metal binding site [ion binding]; metal-binding site 910348002170 catalytic site [active] 910348002171 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 910348002172 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 910348002173 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 910348002174 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 910348002175 active site 910348002176 colicin uptake protein TolQ; Provisional; Region: PRK10801 910348002177 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 910348002178 colicin uptake protein TolR; Provisional; Region: PRK11024 910348002179 TolA C-terminal; Region: TolA; pfam06519 910348002180 translocation protein TolB; Provisional; Region: tolB; PRK03629 910348002181 TolB amino-terminal domain; Region: TolB_N; pfam04052 910348002182 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 910348002183 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 910348002184 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 910348002185 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 910348002186 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 910348002187 ligand binding site [chemical binding]; other site 910348002188 tol-pal system protein YbgF; Provisional; Region: PRK10803 910348002189 Tetratricopeptide repeat; Region: TPR_6; pfam13174 910348002190 Tetratricopeptide repeat; Region: TPR_6; pfam13174 910348002191 quinolinate synthetase; Provisional; Region: PRK09375 910348002192 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 910348002193 zinc transporter ZitB; Provisional; Region: PRK03557 910348002194 YbgS-like protein; Region: YbgS; pfam13985 910348002195 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 910348002196 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 910348002197 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 910348002198 catalytic core [active] 910348002199 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 910348002200 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 910348002201 active site 910348002202 catalytic residues [active] 910348002203 galactokinase; Provisional; Region: PRK05101 910348002204 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 910348002205 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 910348002206 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 910348002207 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 910348002208 dimer interface [polypeptide binding]; other site 910348002209 active site 910348002210 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 910348002211 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 910348002212 NAD(P) binding site [chemical binding]; other site 910348002213 active site 910348002214 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 910348002215 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 910348002216 Walker A/P-loop; other site 910348002217 ATP binding site [chemical binding]; other site 910348002218 Q-loop/lid; other site 910348002219 ABC transporter signature motif; other site 910348002220 Walker B; other site 910348002221 D-loop; other site 910348002222 H-loop/switch region; other site 910348002223 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 910348002224 Walker A/P-loop; other site 910348002225 ATP binding site [chemical binding]; other site 910348002226 Q-loop/lid; other site 910348002227 ABC transporter signature motif; other site 910348002228 Walker B; other site 910348002229 D-loop; other site 910348002230 H-loop/switch region; other site 910348002231 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 910348002232 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 910348002233 molybdenum-pterin binding domain; Region: Mop; TIGR00638 910348002234 TOBE domain; Region: TOBE; pfam03459 910348002235 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 910348002236 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 910348002237 substrate binding pocket [chemical binding]; other site 910348002238 membrane-bound complex binding site; other site 910348002239 hinge residues; other site 910348002240 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 910348002241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348002242 putative PBP binding loops; other site 910348002243 ABC-ATPase subunit interface; other site 910348002244 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 910348002245 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 910348002246 Walker A/P-loop; other site 910348002247 ATP binding site [chemical binding]; other site 910348002248 Q-loop/lid; other site 910348002249 ABC transporter signature motif; other site 910348002250 Walker B; other site 910348002251 D-loop; other site 910348002252 H-loop/switch region; other site 910348002253 molybdenum-pterin binding domain; Region: Mop; TIGR00638 910348002254 6-phosphogluconolactonase; Provisional; Region: PRK11028 910348002255 Transcriptional regulator [Transcription]; Region: LysR; COG0583 910348002256 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348002257 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 910348002258 putative dimerization interface [polypeptide binding]; other site 910348002259 PrpF protein; Region: PrpF; pfam04303 910348002260 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 910348002261 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 910348002262 transmembrane helices; other site 910348002263 putative hydratase; Provisional; Region: PRK11413 910348002264 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 910348002265 substrate binding site [chemical binding]; other site 910348002266 ligand binding site [chemical binding]; other site 910348002267 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 910348002268 substrate binding site [chemical binding]; other site 910348002269 acyl-CoA thioesterase; Provisional; Region: PRK10531 910348002270 putative pectinesterase; Region: PLN02432; cl01911 910348002271 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 910348002272 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 910348002273 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 910348002274 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 910348002275 dimer interface [polypeptide binding]; other site 910348002276 active site 910348002277 Int/Topo IB signature motif; other site 910348002278 Excisionase-like protein; Region: Exc; pfam07825 910348002279 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 910348002280 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 910348002281 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 910348002282 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348002283 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 910348002284 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348002285 Protein of unknown function (DUF1317); Region: DUF1317; pfam07026 910348002286 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 910348002287 RecT family; Region: RecT; cl04285 910348002288 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 910348002289 hypothetical protein; Provisional; Region: PRK09741 910348002290 prophage protein NinE; Provisional; Region: PRK09689 910348002291 Endodeoxyribonuclease RusA; Region: RusA; cl01885 910348002292 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 910348002293 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 910348002294 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 910348002295 trimer interface [polypeptide binding]; other site 910348002296 eyelet of channel; other site 910348002297 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 910348002298 catalytic residues [active] 910348002299 Bor protein; Region: Lambda_Bor; pfam06291 910348002300 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 910348002301 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 910348002302 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 910348002303 Phage Tail Collar Domain; Region: Collar; pfam07484 910348002304 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 910348002305 transcriptional regulator YdeO; Provisional; Region: PRK09940 910348002306 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348002307 Integrase core domain; Region: rve; pfam00665 910348002308 Integrase core domain; Region: rve_3; pfam13683 910348002309 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 910348002310 Transposase; Region: HTH_Tnp_1; pfam01527 910348002311 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 910348002312 substrate binding site [chemical binding]; other site 910348002313 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 910348002314 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 910348002315 inhibitor-cofactor binding pocket; inhibition site 910348002316 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348002317 catalytic residue [active] 910348002318 biotin synthase; Provisional; Region: PRK15108 910348002319 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 910348002320 FeS/SAM binding site; other site 910348002321 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 910348002322 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 910348002323 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 910348002324 substrate-cofactor binding pocket; other site 910348002325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348002326 catalytic residue [active] 910348002327 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 910348002328 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348002329 S-adenosylmethionine binding site [chemical binding]; other site 910348002330 AAA domain; Region: AAA_26; pfam13500 910348002331 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 910348002332 ADP binding site [chemical binding]; other site 910348002333 excinuclease ABC subunit B; Provisional; Region: PRK05298 910348002334 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 910348002335 ATP binding site [chemical binding]; other site 910348002336 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 910348002337 nucleotide binding region [chemical binding]; other site 910348002338 ATP-binding site [chemical binding]; other site 910348002339 Ultra-violet resistance protein B; Region: UvrB; pfam12344 910348002340 UvrB/uvrC motif; Region: UVR; pfam02151 910348002341 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 910348002342 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 910348002343 putative substrate binding pocket [chemical binding]; other site 910348002344 dimer interface [polypeptide binding]; other site 910348002345 phosphate binding site [ion binding]; other site 910348002346 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 910348002347 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 910348002348 FeS/SAM binding site; other site 910348002349 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 910348002350 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 910348002351 MPT binding site; other site 910348002352 trimer interface [polypeptide binding]; other site 910348002353 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 910348002354 trimer interface [polypeptide binding]; other site 910348002355 dimer interface [polypeptide binding]; other site 910348002356 putative active site [active] 910348002357 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 910348002358 MoaE interaction surface [polypeptide binding]; other site 910348002359 MoeB interaction surface [polypeptide binding]; other site 910348002360 thiocarboxylated glycine; other site 910348002361 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 910348002362 MoaE homodimer interface [polypeptide binding]; other site 910348002363 MoaD interaction [polypeptide binding]; other site 910348002364 active site residues [active] 910348002365 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 910348002366 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 910348002367 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 910348002368 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 910348002369 Predicted integral membrane protein [Function unknown]; Region: COG0392 910348002370 cardiolipin synthase 2; Provisional; Region: PRK11263 910348002371 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 910348002372 putative active site [active] 910348002373 catalytic site [active] 910348002374 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 910348002375 putative active site [active] 910348002376 catalytic site [active] 910348002377 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 910348002378 putative catalytic site [active] 910348002379 putative metal binding site [ion binding]; other site 910348002380 putative phosphate binding site [ion binding]; other site 910348002381 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 910348002382 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 910348002383 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 910348002384 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 910348002385 Walker A/P-loop; other site 910348002386 ATP binding site [chemical binding]; other site 910348002387 Q-loop/lid; other site 910348002388 ABC transporter signature motif; other site 910348002389 Walker B; other site 910348002390 D-loop; other site 910348002391 H-loop/switch region; other site 910348002392 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 910348002393 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 910348002394 Walker A/P-loop; other site 910348002395 ATP binding site [chemical binding]; other site 910348002396 Q-loop/lid; other site 910348002397 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 910348002398 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 910348002399 HlyD family secretion protein; Region: HlyD_3; pfam13437 910348002400 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 910348002401 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 910348002402 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 910348002403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236 910348002404 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 910348002405 DEAD_2; Region: DEAD_2; pfam06733 910348002406 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 910348002407 glycosyl transferase family protein; Provisional; Region: PRK08136 910348002408 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 910348002409 putative dehydrogenase; Provisional; Region: PRK10098 910348002410 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 910348002411 hypothetical protein; Provisional; Region: PRK10259 910348002412 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 910348002413 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 910348002414 putative mechanosensitive channel protein; Provisional; Region: PRK11465 910348002415 Mechanosensitive ion channel; Region: MS_channel; pfam00924 910348002416 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 910348002417 Q-loop/lid; other site 910348002418 ABC transporter signature motif; other site 910348002419 Walker B; other site 910348002420 D-loop; other site 910348002421 H-loop/switch region; other site 910348002422 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 910348002423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348002424 dimer interface [polypeptide binding]; other site 910348002425 conserved gate region; other site 910348002426 putative PBP binding loops; other site 910348002427 ABC-ATPase subunit interface; other site 910348002428 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 910348002429 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 910348002430 substrate binding pocket [chemical binding]; other site 910348002431 membrane-bound complex binding site; other site 910348002432 hinge residues; other site 910348002433 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 910348002434 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 910348002435 dimerization interface [polypeptide binding]; other site 910348002436 DPS ferroxidase diiron center [ion binding]; other site 910348002437 ion pore; other site 910348002438 threonine and homoserine efflux system; Provisional; Region: PRK10532 910348002439 EamA-like transporter family; Region: EamA; pfam00892 910348002440 outer membrane protein X; Provisional; Region: ompX; PRK09408 910348002441 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 910348002442 Sulfatase; Region: Sulfatase; pfam00884 910348002443 manganese transport regulator MntR; Provisional; Region: PRK11050 910348002444 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 910348002445 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 910348002446 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 910348002447 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 910348002448 transmembrane helices; other site 910348002449 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 910348002450 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 910348002451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 910348002452 Walker A/P-loop; other site 910348002453 ATP binding site [chemical binding]; other site 910348002454 ABC transporter signature motif; other site 910348002455 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 910348002456 Walker B; other site 910348002457 ABC transporter; Region: ABC_tran_2; pfam12848 910348002458 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 910348002459 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 910348002460 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 910348002461 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 910348002462 active site 910348002463 motif I; other site 910348002464 motif II; other site 910348002465 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 910348002466 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 910348002467 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 910348002468 dimer interface [polypeptide binding]; other site 910348002469 active site 910348002470 glycine loop; other site 910348002471 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 910348002472 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 910348002473 active site 910348002474 intersubunit interactions; other site 910348002475 catalytic residue [active] 910348002476 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 910348002477 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 910348002478 ATP binding site [chemical binding]; other site 910348002479 substrate interface [chemical binding]; other site 910348002480 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 910348002481 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 910348002482 dimer interface [polypeptide binding]; other site 910348002483 putative functional site; other site 910348002484 putative MPT binding site; other site 910348002485 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 910348002486 catalytic nucleophile [active] 910348002487 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 910348002488 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 910348002489 Walker A/P-loop; other site 910348002490 ATP binding site [chemical binding]; other site 910348002491 Q-loop/lid; other site 910348002492 ABC transporter signature motif; other site 910348002493 Walker B; other site 910348002494 D-loop; other site 910348002495 H-loop/switch region; other site 910348002496 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 910348002497 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 910348002498 Walker A/P-loop; other site 910348002499 ATP binding site [chemical binding]; other site 910348002500 Q-loop/lid; other site 910348002501 ABC transporter signature motif; other site 910348002502 Walker B; other site 910348002503 D-loop; other site 910348002504 H-loop/switch region; other site 910348002505 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 910348002506 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 910348002507 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 910348002508 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 910348002509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348002510 dimer interface [polypeptide binding]; other site 910348002511 conserved gate region; other site 910348002512 putative PBP binding loops; other site 910348002513 ABC-ATPase subunit interface; other site 910348002514 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 910348002515 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 910348002516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348002517 dimer interface [polypeptide binding]; other site 910348002518 conserved gate region; other site 910348002519 putative PBP binding loops; other site 910348002520 ABC-ATPase subunit interface; other site 910348002521 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 910348002522 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 910348002523 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 910348002524 metal binding site [ion binding]; metal-binding site 910348002525 active site 910348002526 I-site; other site 910348002527 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 910348002528 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 910348002529 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 910348002530 FeS/SAM binding site; other site 910348002531 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 910348002532 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 910348002533 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 910348002534 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 910348002535 putative C-terminal domain interface [polypeptide binding]; other site 910348002536 putative GSH binding site (G-site) [chemical binding]; other site 910348002537 putative dimer interface [polypeptide binding]; other site 910348002538 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 910348002539 putative N-terminal domain interface [polypeptide binding]; other site 910348002540 putative dimer interface [polypeptide binding]; other site 910348002541 putative substrate binding pocket (H-site) [chemical binding]; other site 910348002542 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 910348002543 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 910348002544 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 910348002545 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 910348002546 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 910348002547 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 910348002548 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 910348002549 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 910348002550 active site 910348002551 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 910348002552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348002553 putative substrate translocation pore; other site 910348002554 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 910348002555 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 910348002556 active site 910348002557 motif I; other site 910348002558 motif II; other site 910348002559 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 910348002560 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 910348002561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348002562 putative substrate translocation pore; other site 910348002563 Major Facilitator Superfamily; Region: MFS_1; pfam07690 910348002564 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 910348002565 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 910348002566 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 910348002567 potential frameshift: common BLAST hit: gi|383177483|ref|YP_005455488.1| putative transporter 910348002568 putative transporter; Provisional; Region: PRK04972 910348002569 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 910348002570 TrkA-C domain; Region: TrkA_C; pfam02080 910348002571 TrkA-C domain; Region: TrkA_C; pfam02080 910348002572 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 910348002573 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 910348002574 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 910348002575 GSH binding site [chemical binding]; other site 910348002576 catalytic residues [active] 910348002577 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 910348002578 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 910348002579 dimer interface [polypeptide binding]; other site 910348002580 FMN binding site [chemical binding]; other site 910348002581 NADPH bind site [chemical binding]; other site 910348002582 RimK-like ATP-grasp domain; Region: RimK; pfam08443 910348002583 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 910348002584 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 910348002585 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 910348002586 spermidine/putrescine ABC transporter ATP-binding subunit; Region: potA; TIGR01187 910348002587 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 910348002588 Q-loop/lid; other site 910348002589 ABC transporter signature motif; other site 910348002590 Walker B; other site 910348002591 D-loop; other site 910348002592 H-loop/switch region; other site 910348002593 TOBE domain; Region: TOBE_2; pfam08402 910348002594 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 910348002595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348002596 dimer interface [polypeptide binding]; other site 910348002597 conserved gate region; other site 910348002598 putative PBP binding loops; other site 910348002599 ABC-ATPase subunit interface; other site 910348002600 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 910348002601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348002602 dimer interface [polypeptide binding]; other site 910348002603 conserved gate region; other site 910348002604 putative PBP binding loops; other site 910348002605 ABC-ATPase subunit interface; other site 910348002606 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 910348002607 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 910348002608 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348002609 S-adenosylmethionine binding site [chemical binding]; other site 910348002610 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 910348002611 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 910348002612 substrate binding pocket [chemical binding]; other site 910348002613 membrane-bound complex binding site; other site 910348002614 hinge residues; other site 910348002615 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348002616 dimer interface [polypeptide binding]; other site 910348002617 conserved gate region; other site 910348002618 putative PBP binding loops; other site 910348002619 ABC-ATPase subunit interface; other site 910348002620 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 910348002621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348002622 dimer interface [polypeptide binding]; other site 910348002623 conserved gate region; other site 910348002624 putative PBP binding loops; other site 910348002625 ABC-ATPase subunit interface; other site 910348002626 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 910348002627 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 910348002628 substrate binding pocket [chemical binding]; other site 910348002629 membrane-bound complex binding site; other site 910348002630 hinge residues; other site 910348002631 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 910348002632 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 910348002633 Walker A/P-loop; other site 910348002634 ATP binding site [chemical binding]; other site 910348002635 Q-loop/lid; other site 910348002636 ABC transporter signature motif; other site 910348002637 Walker B; other site 910348002638 D-loop; other site 910348002639 H-loop/switch region; other site 910348002640 putative lipoprotein; Provisional; Region: PRK10533 910348002641 hypothetical protein; Provisional; Region: PRK02877 910348002642 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 910348002643 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 910348002644 amidase catalytic site [active] 910348002645 Zn binding residues [ion binding]; other site 910348002646 substrate binding site [chemical binding]; other site 910348002647 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 910348002648 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 910348002649 NAD(P) binding site [chemical binding]; other site 910348002650 active site 910348002651 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 910348002652 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 910348002653 active site 910348002654 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 910348002655 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 910348002656 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 910348002657 tetramer interface [polypeptide binding]; other site 910348002658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348002659 catalytic residue [active] 910348002660 pyruvate dehydrogenase; Provisional; Region: PRK09124 910348002661 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 910348002662 PYR/PP interface [polypeptide binding]; other site 910348002663 dimer interface [polypeptide binding]; other site 910348002664 tetramer interface [polypeptide binding]; other site 910348002665 TPP binding site [chemical binding]; other site 910348002666 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 910348002667 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 910348002668 TPP-binding site [chemical binding]; other site 910348002669 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 910348002670 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 910348002671 FAD binding pocket [chemical binding]; other site 910348002672 FAD binding motif [chemical binding]; other site 910348002673 phosphate binding motif [ion binding]; other site 910348002674 beta-alpha-beta structure motif; other site 910348002675 NAD binding pocket [chemical binding]; other site 910348002676 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 910348002677 catalytic loop [active] 910348002678 iron binding site [ion binding]; other site 910348002679 hybrid cluster protein; Provisional; Region: PRK05290 910348002680 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 910348002681 ACS interaction site; other site 910348002682 CODH interaction site; other site 910348002683 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 910348002684 hybrid metal cluster; other site 910348002685 Predicted membrane protein [Function unknown]; Region: COG2431 910348002686 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 910348002687 amphipathic channel; other site 910348002688 Asn-Pro-Ala signature motifs; other site 910348002689 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 910348002690 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 910348002691 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 910348002692 putative active site [active] 910348002693 putative metal-binding site [ion binding]; other site 910348002694 Protein of unknown function (DUF535); Region: DUF535; pfam04393 910348002695 macrolide transporter subunit MacA; Provisional; Region: PRK11578 910348002696 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 910348002697 HlyD family secretion protein; Region: HlyD_3; pfam13437 910348002698 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 910348002699 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 910348002700 Walker A/P-loop; other site 910348002701 ATP binding site [chemical binding]; other site 910348002702 Q-loop/lid; other site 910348002703 ABC transporter signature motif; other site 910348002704 Walker B; other site 910348002705 D-loop; other site 910348002706 H-loop/switch region; other site 910348002707 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 910348002708 FtsX-like permease family; Region: FtsX; pfam02687 910348002709 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 910348002710 DNA-binding site [nucleotide binding]; DNA binding site 910348002711 RNA-binding motif; other site 910348002712 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 910348002713 Clp amino terminal domain; Region: Clp_N; pfam02861 910348002714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348002715 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 910348002716 Walker A motif; other site 910348002717 ATP binding site [chemical binding]; other site 910348002718 Walker B motif; other site 910348002719 arginine finger; other site 910348002720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348002721 Walker A motif; other site 910348002722 ATP binding site [chemical binding]; other site 910348002723 Walker B motif; other site 910348002724 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 910348002725 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 910348002726 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 910348002727 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 910348002728 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 910348002729 Walker A/P-loop; other site 910348002730 ATP binding site [chemical binding]; other site 910348002731 Q-loop/lid; other site 910348002732 ABC transporter signature motif; other site 910348002733 Walker B; other site 910348002734 D-loop; other site 910348002735 H-loop/switch region; other site 910348002736 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 910348002737 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 910348002738 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 910348002739 Walker A/P-loop; other site 910348002740 ATP binding site [chemical binding]; other site 910348002741 Q-loop/lid; other site 910348002742 ABC transporter signature motif; other site 910348002743 Walker B; other site 910348002744 D-loop; other site 910348002745 H-loop/switch region; other site 910348002746 thioredoxin reductase; Provisional; Region: PRK10262 910348002747 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 910348002748 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 910348002749 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 910348002750 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 910348002751 putative DNA binding site [nucleotide binding]; other site 910348002752 putative Zn2+ binding site [ion binding]; other site 910348002753 AsnC family; Region: AsnC_trans_reg; pfam01037 910348002754 DNA translocase FtsK; Provisional; Region: PRK10263 910348002755 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 910348002756 DNA translocase FtsK; Provisional; Region: PRK10263 910348002757 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 910348002758 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 910348002759 periplasmic chaperone LolA; Region: lolA; TIGR00547 910348002760 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 910348002761 recombination factor protein RarA; Reviewed; Region: PRK13342 910348002762 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348002763 Walker A motif; other site 910348002764 ATP binding site [chemical binding]; other site 910348002765 Walker B motif; other site 910348002766 arginine finger; other site 910348002767 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 910348002768 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 910348002769 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 910348002770 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 910348002771 putative [Fe4-S4] binding site [ion binding]; other site 910348002772 putative molybdopterin cofactor binding site [chemical binding]; other site 910348002773 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 910348002774 putative molybdopterin cofactor binding site; other site 910348002775 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 910348002776 4Fe-4S binding domain; Region: Fer4; pfam00037 910348002777 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 910348002778 Isochorismatase family; Region: Isochorismatase; pfam00857 910348002779 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 910348002780 catalytic triad [active] 910348002781 dimer interface [polypeptide binding]; other site 910348002782 conserved cis-peptide bond; other site 910348002783 putative MFS family transporter protein; Provisional; Region: PRK03633 910348002784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348002785 putative substrate translocation pore; other site 910348002786 Amino acid permease; Region: AA_permease_2; pfam13520 910348002787 hypothetical protein; Provisional; Region: PRK09739 910348002788 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 910348002789 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 910348002790 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 910348002791 FeS/SAM binding site; other site 910348002792 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 910348002793 Pyruvate formate lyase 1; Region: PFL1; cd01678 910348002794 coenzyme A binding site [chemical binding]; other site 910348002795 active site 910348002796 catalytic residues [active] 910348002797 glycine loop; other site 910348002798 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 910348002799 uncharacterized domain; Region: TIGR00702 910348002800 YcaO-like family; Region: YcaO; pfam02624 910348002801 Predicted membrane protein [Function unknown]; Region: COG2323 910348002802 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 910348002803 homodimer interface [polypeptide binding]; other site 910348002804 substrate-cofactor binding pocket; other site 910348002805 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348002806 catalytic residue [active] 910348002807 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 910348002808 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 910348002809 hinge; other site 910348002810 active site 910348002811 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 910348002812 cytidylate kinase; Provisional; Region: cmk; PRK00023 910348002813 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 910348002814 CMP-binding site; other site 910348002815 The sites determining sugar specificity; other site 910348002816 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 910348002817 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 910348002818 RNA binding site [nucleotide binding]; other site 910348002819 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 910348002820 RNA binding site [nucleotide binding]; other site 910348002821 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 910348002822 RNA binding site [nucleotide binding]; other site 910348002823 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 910348002824 RNA binding site [nucleotide binding]; other site 910348002825 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 910348002826 RNA binding site [nucleotide binding]; other site 910348002827 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 910348002828 IHF dimer interface [polypeptide binding]; other site 910348002829 IHF - DNA interface [nucleotide binding]; other site 910348002830 ComEC family competence protein; Provisional; Region: PRK11539 910348002831 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 910348002832 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 910348002833 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 910348002834 potential frameshift: common BLAST hit: gi|378713680|ref|YP_005278573.1| lipid A ABC exporter, fused ATPase and inner membrane subunits MsbA 910348002835 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 910348002836 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 910348002837 Walker A/P-loop; other site 910348002838 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 910348002839 Q-loop/lid; other site 910348002840 ABC transporter signature motif; other site 910348002841 Walker B; other site 910348002842 D-loop; other site 910348002843 H-loop/switch region; other site 910348002844 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 910348002845 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 910348002846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 910348002847 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 910348002848 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 910348002849 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 910348002850 Ligand binding site; other site 910348002851 oligomer interface; other site 910348002852 hypothetical protein; Provisional; Region: PRK10593 910348002853 Uncharacterized conserved protein [Function unknown]; Region: COG1434 910348002854 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 910348002855 putative active site [active] 910348002856 Methyltransferase domain; Region: Methyltransf_31; pfam13847 910348002857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348002858 S-adenosylmethionine binding site [chemical binding]; other site 910348002859 condesin subunit F; Provisional; Region: PRK05260 910348002860 condesin subunit E; Provisional; Region: PRK05256 910348002861 murein L,D-transpeptidase; Provisional; Region: PRK10594 910348002862 murein L,D-transpeptidase; Provisional; Region: PRK10594 910348002863 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 910348002864 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 910348002865 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 910348002866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 910348002867 Peptidase M15; Region: Peptidase_M15_3; cl01194 910348002868 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 910348002869 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 910348002870 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 910348002871 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348002872 homodimer interface [polypeptide binding]; other site 910348002873 catalytic residue [active] 910348002874 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 910348002875 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 910348002876 trimer interface [polypeptide binding]; other site 910348002877 eyelet of channel; other site 910348002878 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 910348002879 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 910348002880 putative dimer interface [polypeptide binding]; other site 910348002881 putative anticodon binding site; other site 910348002882 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 910348002883 homodimer interface [polypeptide binding]; other site 910348002884 motif 1; other site 910348002885 motif 2; other site 910348002886 active site 910348002887 motif 3; other site 910348002888 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 910348002889 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 910348002890 active site 910348002891 aminopeptidase N; Provisional; Region: pepN; PRK14015 910348002892 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 910348002893 active site 910348002894 Zn binding site [ion binding]; other site 910348002895 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 910348002896 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 910348002897 Walker A/P-loop; other site 910348002898 ATP binding site [chemical binding]; other site 910348002899 Q-loop/lid; other site 910348002900 ABC transporter signature motif; other site 910348002901 Walker B; other site 910348002902 D-loop; other site 910348002903 H-loop/switch region; other site 910348002904 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 910348002905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348002906 dimer interface [polypeptide binding]; other site 910348002907 conserved gate region; other site 910348002908 putative PBP binding loops; other site 910348002909 ABC-ATPase subunit interface; other site 910348002910 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 910348002911 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 910348002912 active site 910348002913 dimer interface [polypeptide binding]; other site 910348002914 non-prolyl cis peptide bond; other site 910348002915 insertion regions; other site 910348002916 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 910348002917 substrate binding pocket [chemical binding]; other site 910348002918 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 910348002919 membrane-bound complex binding site; other site 910348002920 hinge residues; other site 910348002921 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 910348002922 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 910348002923 Fimbrial protein; Region: Fimbrial; cl01416 910348002924 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 910348002925 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 910348002926 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 910348002927 outer membrane usher protein; Provisional; Region: PRK15193 910348002928 PapC N-terminal domain; Region: PapC_N; pfam13954 910348002929 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 910348002930 PapC C-terminal domain; Region: PapC_C; pfam13953 910348002931 Fimbrial protein; Region: Fimbrial; cl01416 910348002932 Fimbrial protein; Region: Fimbrial; cl01416 910348002933 Fimbrial protein; Region: Fimbrial; cl01416 910348002934 putativi pili assembly chaperone; Provisional; Region: PRK11385 910348002935 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 910348002936 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 910348002937 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 910348002938 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 910348002939 quinone interaction residues [chemical binding]; other site 910348002940 active site 910348002941 catalytic residues [active] 910348002942 FMN binding site [chemical binding]; other site 910348002943 substrate binding site [chemical binding]; other site 910348002944 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 910348002945 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 910348002946 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 910348002947 MOSC domain; Region: MOSC; pfam03473 910348002948 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 910348002949 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 910348002950 catalytic loop [active] 910348002951 iron binding site [ion binding]; other site 910348002952 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 910348002953 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 910348002954 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 910348002955 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348002956 S-adenosylmethionine binding site [chemical binding]; other site 910348002957 ABC transporter ATPase component; Reviewed; Region: PRK11147 910348002958 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 910348002959 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 910348002960 Walker A/P-loop; other site 910348002961 Walker A/P-loop; other site 910348002962 ATP binding site [chemical binding]; other site 910348002963 ATP binding site [chemical binding]; other site 910348002964 Q-loop/lid; other site 910348002965 Q-loop/lid; other site 910348002966 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 910348002967 ABC transporter signature motif; other site 910348002968 Walker B; other site 910348002969 D-loop; other site 910348002970 ABC transporter; Region: ABC_tran_2; pfam12848 910348002971 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 910348002972 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 910348002973 Paraquat-inducible protein A; Region: PqiA; pfam04403 910348002974 Paraquat-inducible protein A; Region: PqiA; pfam04403 910348002975 paraquat-inducible protein B; Provisional; Region: PRK10807 910348002976 mce related protein; Region: MCE; pfam02470 910348002977 mce related protein; Region: MCE; pfam02470 910348002978 mce related protein; Region: MCE; pfam02470 910348002979 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 910348002980 Protein of unknown function (DUF330); Region: DUF330; pfam03886 910348002981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 910348002982 ribosome modulation factor; Provisional; Region: PRK14563 910348002983 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 910348002984 active site 1 [active] 910348002985 dimer interface [polypeptide binding]; other site 910348002986 active site 2 [active] 910348002987 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 910348002988 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 910348002989 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 910348002990 outer membrane protein A; Reviewed; Region: PRK10808 910348002991 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 910348002992 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 910348002993 ligand binding site [chemical binding]; other site 910348002994 cell division inhibitor SulA; Region: sula; TIGR00623 910348002995 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 910348002996 TfoX C-terminal domain; Region: TfoX_C; pfam04994 910348002997 TIGR01666 family membrane protein; Region: YCCS 910348002998 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 910348002999 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 910348003000 Predicted membrane protein [Function unknown]; Region: COG3304 910348003001 Domain of unknown function (DUF307); Region: DUF307; pfam03733 910348003002 Domain of unknown function (DUF307); Region: DUF307; pfam03733 910348003003 DNA helicase IV; Provisional; Region: helD; PRK11054 910348003004 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 910348003005 Part of AAA domain; Region: AAA_19; pfam13245 910348003006 Family description; Region: UvrD_C_2; pfam13538 910348003007 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 910348003008 active site 910348003009 dimer interfaces [polypeptide binding]; other site 910348003010 catalytic residues [active] 910348003011 hypothetical protein; Provisional; Region: PRK03641 910348003012 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 910348003013 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 910348003014 heat shock protein HspQ; Provisional; Region: PRK14129 910348003015 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 910348003016 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 910348003017 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 910348003018 putative RNA binding site [nucleotide binding]; other site 910348003019 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348003020 S-adenosylmethionine binding site [chemical binding]; other site 910348003021 Acylphosphatase; Region: Acylphosphatase; cl00551 910348003022 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 910348003023 sulfur transfer protein TusE; Provisional; Region: PRK11508 910348003024 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 910348003025 YccA-like proteins; Region: YccA_like; cd10433 910348003026 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 910348003027 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 910348003028 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 910348003029 hydrogenase 1 large subunit; Provisional; Region: PRK10170 910348003030 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 910348003031 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 910348003032 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 910348003033 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 910348003034 putative substrate-binding site; other site 910348003035 nickel binding site [ion binding]; other site 910348003036 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 910348003037 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 910348003038 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 910348003039 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 910348003040 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 910348003041 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 910348003042 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 910348003043 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 910348003044 catalytic core [active] 910348003045 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 910348003046 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 910348003047 Chain length determinant protein; Region: Wzz; pfam02706 910348003048 Chain length determinant protein; Region: Wzz; cl15801 910348003049 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 910348003050 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 910348003051 Nucleotide binding site [chemical binding]; other site 910348003052 Low molecular weight phosphatase family; Region: LMWPc; cd00115 910348003053 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 910348003054 active site 910348003055 polysaccharide export protein Wza; Provisional; Region: PRK15078 910348003056 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 910348003057 SLBB domain; Region: SLBB; pfam10531 910348003058 SLBB domain; Region: SLBB; pfam10531 910348003059 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 910348003060 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 910348003061 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 910348003062 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348003063 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 910348003064 DNA-binding site [nucleotide binding]; DNA binding site 910348003065 RNA-binding motif; other site 910348003066 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 910348003067 DNA-binding site [nucleotide binding]; DNA binding site 910348003068 RNA-binding motif; other site 910348003069 cold shock gene; Provisional; Region: PRK09891 910348003070 GnsA/GnsB family; Region: GnsAB; pfam08178 910348003071 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 910348003072 4Fe-4S binding domain; Region: Fer4_5; pfam12801 910348003073 4Fe-4S binding domain; Region: Fer4_5; pfam12801 910348003074 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 910348003075 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 910348003076 HAMP domain; Region: HAMP; pfam00672 910348003077 dimerization interface [polypeptide binding]; other site 910348003078 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 910348003079 dimer interface [polypeptide binding]; other site 910348003080 phosphorylation site [posttranslational modification] 910348003081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348003082 ATP binding site [chemical binding]; other site 910348003083 Mg2+ binding site [ion binding]; other site 910348003084 G-X-G motif; other site 910348003085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348003086 active site 910348003087 phosphorylation site [posttranslational modification] 910348003088 intermolecular recognition site; other site 910348003089 dimerization interface [polypeptide binding]; other site 910348003090 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 910348003091 putative binding surface; other site 910348003092 active site 910348003093 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 910348003094 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 910348003095 putative ligand binding site [chemical binding]; other site 910348003096 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 910348003097 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348003098 active site 910348003099 phosphorylation site [posttranslational modification] 910348003100 intermolecular recognition site; other site 910348003101 dimerization interface [polypeptide binding]; other site 910348003102 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 910348003103 DNA binding site [nucleotide binding] 910348003104 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 910348003105 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 910348003106 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 910348003107 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 910348003108 molybdopterin cofactor binding site [chemical binding]; other site 910348003109 substrate binding site [chemical binding]; other site 910348003110 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 910348003111 molybdopterin cofactor binding site; other site 910348003112 chaperone protein TorD; Validated; Region: torD; PRK04976 910348003113 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 910348003114 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 910348003115 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 910348003116 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 910348003117 HSP70 interaction site [polypeptide binding]; other site 910348003118 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 910348003119 substrate binding site [polypeptide binding]; other site 910348003120 dimer interface [polypeptide binding]; other site 910348003121 hypothetical protein; Provisional; Region: PRK09784 910348003122 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 910348003123 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 910348003124 catalytic core [active] 910348003125 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 910348003126 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 910348003127 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 910348003128 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 910348003129 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 910348003130 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 910348003131 putative FMN binding site [chemical binding]; other site 910348003132 pyrimidine utilization protein D; Region: RutD; TIGR03611 910348003133 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 910348003134 homotrimer interaction site [polypeptide binding]; other site 910348003135 putative active site [active] 910348003136 Isochorismatase family; Region: Isochorismatase; pfam00857 910348003137 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 910348003138 catalytic triad [active] 910348003139 conserved cis-peptide bond; other site 910348003140 pyrimidine utilization protein A; Region: RutA; TIGR03612 910348003141 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 910348003142 active site 910348003143 dimer interface [polypeptide binding]; other site 910348003144 non-prolyl cis peptide bond; other site 910348003145 insertion regions; other site 910348003146 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 910348003147 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 910348003148 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 910348003149 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 910348003150 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 910348003151 Predicted transcriptional regulator [Transcription]; Region: COG3905 910348003152 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 910348003153 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 910348003154 Glutamate binding site [chemical binding]; other site 910348003155 NAD binding site [chemical binding]; other site 910348003156 catalytic residues [active] 910348003157 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 910348003158 Na binding site [ion binding]; other site 910348003159 FTR1 family protein; Region: TIGR00145 910348003160 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 910348003161 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 910348003162 Imelysin; Region: Peptidase_M75; pfam09375 910348003163 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 910348003164 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 910348003165 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 910348003166 hypothetical protein; Provisional; Region: PRK10536 910348003167 putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585 910348003168 N-glycosyltransferase; Provisional; Region: PRK11204 910348003169 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 910348003170 DXD motif; other site 910348003171 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 910348003172 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 910348003173 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 910348003174 putative active site [active] 910348003175 putative metal binding site [ion binding]; other site 910348003176 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 910348003177 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 910348003178 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 910348003179 metal binding site [ion binding]; metal-binding site 910348003180 active site 910348003181 I-site; other site 910348003182 Transposase; Region: HTH_Tnp_1; cl17663 910348003183 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 910348003184 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 910348003185 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 910348003186 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 910348003187 substrate binding site [chemical binding]; other site 910348003188 dimer interface [polypeptide binding]; other site 910348003189 ATP binding site [chemical binding]; other site 910348003190 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 910348003191 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 910348003192 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 910348003193 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 910348003194 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 910348003195 Transposase; Region: HTH_Tnp_1; pfam01527 910348003196 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 910348003197 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 910348003198 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 910348003199 homodimer interface [polypeptide binding]; other site 910348003200 putative GKAP docking site [polypeptide binding]; other site 910348003201 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 910348003202 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 910348003203 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 910348003204 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 910348003205 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 910348003206 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 910348003207 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 910348003208 Transposase; Region: HTH_Tnp_1; cl17663 910348003209 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 910348003210 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 910348003211 HTH-like domain; Region: HTH_21; pfam13276 910348003212 Integrase core domain; Region: rve; pfam00665 910348003213 Integrase core domain; Region: rve_3; pfam13683 910348003214 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 910348003215 homotrimer interface [polypeptide binding]; other site 910348003216 Walker A motif; other site 910348003217 GTP binding site [chemical binding]; other site 910348003218 Walker B motif; other site 910348003219 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 910348003220 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 910348003221 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 910348003222 putative dimer interface [polypeptide binding]; other site 910348003223 active site pocket [active] 910348003224 putative cataytic base [active] 910348003225 L,D-transpeptidase; Provisional; Region: PRK10190 910348003226 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 910348003227 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 910348003228 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348003229 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 910348003230 putative dimerization interface [polypeptide binding]; other site 910348003231 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 910348003232 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348003233 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 910348003234 putative substrate binding site [chemical binding]; other site 910348003235 dimerization interface [polypeptide binding]; other site 910348003236 MATE family multidrug exporter; Provisional; Region: PRK10189 910348003237 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 910348003238 Transcriptional regulator; Region: Transcrip_reg; cl00361 910348003239 AMP nucleosidase; Provisional; Region: PRK08292 910348003240 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 910348003241 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 910348003242 shikimate transporter; Provisional; Region: PRK09952 910348003243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348003244 putative substrate translocation pore; other site 910348003245 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 910348003246 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 910348003247 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 910348003248 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 910348003249 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 910348003250 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 910348003251 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 910348003252 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 910348003253 Transposase; Region: HTH_Tnp_1; cl17663 910348003254 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 910348003255 HTH-like domain; Region: HTH_21; pfam13276 910348003256 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 910348003257 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 910348003258 putative active site [active] 910348003259 putative NTP binding site [chemical binding]; other site 910348003260 putative nucleic acid binding site [nucleotide binding]; other site 910348003261 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 910348003262 Integrase core domain; Region: rve; pfam00665 910348003263 Integrase core domain; Region: rve_3; pfam13683 910348003264 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 910348003265 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 910348003266 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 910348003267 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 910348003268 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 910348003269 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 910348003270 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 910348003271 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 910348003272 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 910348003273 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 910348003274 Transposase; Region: HTH_Tnp_1; pfam01527 910348003275 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 910348003276 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 910348003277 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 910348003278 homodimer interface [polypeptide binding]; other site 910348003279 putative GKAP docking site [polypeptide binding]; other site 910348003280 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 910348003281 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 910348003282 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 910348003283 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 910348003284 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 910348003285 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 910348003286 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 910348003287 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 910348003288 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 910348003289 Integrase core domain; Region: rve; pfam00665 910348003290 YodA lipocalin-like domain; Region: YodA; cl01365 910348003291 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 910348003292 TMAO/DMSO reductase; Reviewed; Region: PRK05363 910348003293 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 910348003294 Moco binding site; other site 910348003295 metal coordination site [ion binding]; other site 910348003296 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 910348003297 active site 910348003298 homotetramer interface [polypeptide binding]; other site 910348003299 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 910348003300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348003301 active site 910348003302 phosphorylation site [posttranslational modification] 910348003303 intermolecular recognition site; other site 910348003304 dimerization interface [polypeptide binding]; other site 910348003305 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 910348003306 DNA binding site [nucleotide binding] 910348003307 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 910348003308 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 910348003309 dimer interface [polypeptide binding]; other site 910348003310 phosphorylation site [posttranslational modification] 910348003311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348003312 ATP binding site [chemical binding]; other site 910348003313 Mg2+ binding site [ion binding]; other site 910348003314 G-X-G motif; other site 910348003315 chaperone protein HchA; Provisional; Region: PRK04155 910348003316 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 910348003317 dimer interface [polypeptide binding]; other site 910348003318 metal binding site [ion binding]; metal-binding site 910348003319 potential oxyanion hole; other site 910348003320 potential catalytic triad [active] 910348003321 conserved cys residue [active] 910348003322 Transposase domain (DUF772); Region: DUF772; pfam05598 910348003323 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 910348003324 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 910348003325 putative transposase OrfB; Reviewed; Region: PHA02517 910348003326 Integrase core domain; Region: rve; pfam00665 910348003327 Integrase core domain; Region: rve_3; pfam13683 910348003328 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 910348003329 DNA-binding interface [nucleotide binding]; DNA binding site 910348003330 Helix-turn-helix domain; Region: HTH_38; pfam13936 910348003331 Homeodomain-like domain; Region: HTH_32; pfam13565 910348003332 Integrase core domain; Region: rve; pfam00665 910348003333 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 910348003334 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 910348003335 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348003336 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 910348003337 Transposase; Region: HTH_Tnp_1; pfam01527 910348003338 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 910348003339 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 910348003340 eyelet of channel; other site 910348003341 trimer interface [polypeptide binding]; other site 910348003342 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 910348003343 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 910348003344 Zn2+ binding site [ion binding]; other site 910348003345 Mg2+ binding site [ion binding]; other site 910348003346 DNA cytosine methylase; Provisional; Region: PRK10458 910348003347 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 910348003348 cofactor binding site; other site 910348003349 DNA binding site [nucleotide binding] 910348003350 substrate interaction site [chemical binding]; other site 910348003351 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 910348003352 additional DNA contacts [nucleotide binding]; other site 910348003353 mismatch recognition site; other site 910348003354 active site 910348003355 zinc binding site [ion binding]; other site 910348003356 DNA intercalation site [nucleotide binding]; other site 910348003357 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 910348003358 EamA-like transporter family; Region: EamA; pfam00892 910348003359 hypothetical protein; Provisional; Region: PRK10062 910348003360 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 910348003361 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 910348003362 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 910348003363 metal binding site [ion binding]; metal-binding site 910348003364 active site 910348003365 I-site; other site 910348003366 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 910348003367 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 910348003368 active site 910348003369 motif I; other site 910348003370 motif II; other site 910348003371 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 910348003372 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 910348003373 DNA binding residues [nucleotide binding] 910348003374 dimerization interface [polypeptide binding]; other site 910348003375 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 910348003376 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 910348003377 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 910348003378 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 910348003379 flagellar motor switch protein; Validated; Region: fliN; PRK05698 910348003380 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 910348003381 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 910348003382 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 910348003383 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 910348003384 flagellar hook-length control protein; Provisional; Region: PRK10118 910348003385 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 910348003386 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 910348003387 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 910348003388 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 910348003389 Walker A motif/ATP binding site; other site 910348003390 Walker B motif; other site 910348003391 flagellar assembly protein H; Validated; Region: fliH; PRK05687 910348003392 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 910348003393 Flagellar assembly protein FliH; Region: FliH; pfam02108 910348003394 flagellar motor switch protein FliG; Region: fliG; TIGR00207 910348003395 FliG C-terminal domain; Region: FliG_C; pfam01706 910348003396 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 910348003397 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 910348003398 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 910348003399 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 910348003400 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 910348003401 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 910348003402 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 910348003403 Int/Topo IB signature motif; other site 910348003404 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 910348003405 xylulokinase; Provisional; Region: PRK15027 910348003406 Protein of unknown function (DUF551); Region: DUF551; pfam04448 910348003407 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 910348003408 RecT family; Region: RecT; pfam03837 910348003409 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 910348003410 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 910348003411 cIII protein family; Region: cIII; pfam08134 910348003412 36-mer N-terminal peptide of the N protein (N36); Region: N36; pfam11438 910348003413 Predicted transcriptional regulator [Transcription]; Region: COG2932 910348003414 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 910348003415 Catalytic site [active] 910348003416 Bacteriophage CII protein; Region: Phage_CII; pfam05269 910348003417 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 910348003418 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 910348003419 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 910348003420 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 910348003421 Walker A motif; other site 910348003422 ATP binding site [chemical binding]; other site 910348003423 Walker B motif; other site 910348003424 DNA binding loops [nucleotide binding] 910348003425 phage N-6-adenine-methyltransferase; Region: phage_N6A_met; TIGR01712 910348003426 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 910348003427 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 910348003428 Endodeoxyribonuclease RusA; Region: RusA; cl01885 910348003429 Phage NinH protein; Region: Phage_NinH; pfam06322 910348003430 Antitermination protein; Region: Antiterm; pfam03589 910348003431 Antitermination protein; Region: Antiterm; pfam03589 910348003432 phage holin, lambda family; Region: holin_lambda; TIGR01594 910348003433 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 910348003434 N-acetyl-D-glucosamine binding site [chemical binding]; other site 910348003435 catalytic residue [active] 910348003436 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 910348003437 KilA-N domain; Region: KilA-N; pfam04383 910348003438 ORF11CD3 domain; Region: ORF11CD3; pfam10549 910348003439 hypothetical protein; Region: PHA01971 910348003440 Terminase-like family; Region: Terminase_6; pfam03237 910348003441 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 910348003442 Bacteriophage, scaffolding protein; Region: Phage-scaffold; pfam09306 910348003443 coat protein; Region: PHA01511 910348003444 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 910348003445 P22 tail accessory factor; Region: P22_Tail-4; pfam11650 910348003446 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 910348003447 Mnt; Region: mnt; PHA01513 910348003448 Arc-like DNA binding domain; Region: Arc; pfam03869 910348003449 Regulatory protein Mnt; Region: Repressor_Mnt; pfam11423 910348003450 Head binding; Region: Head_binding; pfam09008 910348003451 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 910348003452 multidrug efflux protein; Reviewed; Region: emrE; PRK09541 910348003453 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 910348003454 substrate binding site [chemical binding]; other site 910348003455 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 910348003456 Transposase IS200 like; Region: Y1_Tnp; pfam01797 910348003457 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 910348003458 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 910348003459 Probable transposase; Region: OrfB_IS605; pfam01385 910348003460 putative inner membrane protein; Provisional; Region: PRK11099 910348003461 YedD-like protein; Region: YedD; cl08117 910348003462 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 910348003463 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 910348003464 active site 910348003465 Na/Ca binding site [ion binding]; other site 910348003466 catalytic site [active] 910348003467 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 910348003468 Flagellar protein FliS; Region: FliS; cl00654 910348003469 flagellar capping protein; Reviewed; Region: fliD; PRK08032 910348003470 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 910348003471 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 910348003472 flagellin; Validated; Region: PRK06819 910348003473 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 910348003474 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 910348003475 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 910348003476 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 910348003477 DNA binding residues [nucleotide binding] 910348003478 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348003479 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 910348003480 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 910348003481 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 910348003482 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 910348003483 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 910348003484 cystine transporter subunit; Provisional; Region: PRK11260 910348003485 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 910348003486 substrate binding pocket [chemical binding]; other site 910348003487 membrane-bound complex binding site; other site 910348003488 hinge residues; other site 910348003489 D-cysteine desulfhydrase; Validated; Region: PRK03910 910348003490 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 910348003491 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348003492 catalytic residue [active] 910348003493 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 910348003494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348003495 dimer interface [polypeptide binding]; other site 910348003496 conserved gate region; other site 910348003497 putative PBP binding loops; other site 910348003498 ABC-ATPase subunit interface; other site 910348003499 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 910348003500 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 910348003501 Walker A/P-loop; other site 910348003502 ATP binding site [chemical binding]; other site 910348003503 Q-loop/lid; other site 910348003504 ABC transporter signature motif; other site 910348003505 Walker B; other site 910348003506 D-loop; other site 910348003507 H-loop/switch region; other site 910348003508 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 910348003509 Autoinducer binding domain; Region: Autoind_bind; pfam03472 910348003510 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 910348003511 DNA binding residues [nucleotide binding] 910348003512 dimerization interface [polypeptide binding]; other site 910348003513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348003514 active site 910348003515 phosphorylation site [posttranslational modification] 910348003516 intermolecular recognition site; other site 910348003517 dimerization interface [polypeptide binding]; other site 910348003518 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 910348003519 DNA binding residues [nucleotide binding] 910348003520 dimerization interface [polypeptide binding]; other site 910348003521 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 910348003522 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 910348003523 active site 910348003524 catalytic site [active] 910348003525 putative DNA binding site [nucleotide binding]; other site 910348003526 GIY-YIG motif/motif A; other site 910348003527 metal binding site [ion binding]; metal-binding site 910348003528 UvrB/uvrC motif; Region: UVR; pfam02151 910348003529 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 910348003530 Helix-hairpin-helix motif; Region: HHH; pfam00633 910348003531 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 910348003532 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 910348003533 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 910348003534 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 910348003535 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 910348003536 serine transporter; Region: stp; TIGR00814 910348003537 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 910348003538 Transposase domain (DUF772); Region: DUF772; pfam05598 910348003539 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 910348003540 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 910348003541 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 910348003542 active site 910348003543 Int/Topo IB signature motif; other site 910348003544 DNA binding site [nucleotide binding] 910348003545 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348003546 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 910348003547 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 910348003548 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 910348003549 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348003550 flagellin; Validated; Region: PRK08026 910348003551 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 910348003552 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 910348003553 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 910348003554 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 910348003555 Probable transposase; Region: OrfB_IS605; pfam01385 910348003556 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 910348003557 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 910348003558 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 910348003559 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 910348003560 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 910348003561 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 910348003562 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 910348003563 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 910348003564 Part of AAA domain; Region: AAA_19; pfam13245 910348003565 AAA domain; Region: AAA_22; pfam13401 910348003566 Transposase; Region: HTH_Tnp_1; cl17663 910348003567 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 910348003568 putative transposase OrfB; Reviewed; Region: PHA02517 910348003569 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 910348003570 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 910348003571 putative active site [active] 910348003572 putative NTP binding site [chemical binding]; other site 910348003573 putative nucleic acid binding site [nucleotide binding]; other site 910348003574 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 910348003575 Integrase core domain; Region: rve; pfam00665 910348003576 Integrase core domain; Region: rve_3; pfam13683 910348003577 Transposase domain (DUF772); Region: DUF772; pfam05598 910348003578 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 910348003579 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 910348003580 Integrase core domain; Region: rve; pfam00665 910348003581 Integrase core domain; Region: rve_3; pfam13683 910348003582 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 910348003583 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 910348003584 putative active site [active] 910348003585 putative NTP binding site [chemical binding]; other site 910348003586 putative nucleic acid binding site [nucleotide binding]; other site 910348003587 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 910348003588 HTH-like domain; Region: HTH_21; pfam13276 910348003589 hypothetical protein; Provisional; Region: PRK10396 910348003590 yecA family protein; Region: ygfB_yecA; TIGR02292 910348003591 SEC-C motif; Region: SEC-C; pfam02810 910348003592 tyrosine transporter TyrP; Provisional; Region: PRK15132 910348003593 aromatic amino acid transport protein; Region: araaP; TIGR00837 910348003594 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 910348003595 Ferritin-like domain; Region: Ferritin; pfam00210 910348003596 ferroxidase diiron center [ion binding]; other site 910348003597 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348003598 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 910348003599 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 910348003600 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 910348003601 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 910348003602 Ferritin-like domain; Region: Ferritin; pfam00210 910348003603 ferroxidase diiron center [ion binding]; other site 910348003604 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 910348003605 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 910348003606 ligand binding site [chemical binding]; other site 910348003607 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 910348003608 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 910348003609 Walker A/P-loop; other site 910348003610 ATP binding site [chemical binding]; other site 910348003611 Q-loop/lid; other site 910348003612 ABC transporter signature motif; other site 910348003613 Walker B; other site 910348003614 D-loop; other site 910348003615 H-loop/switch region; other site 910348003616 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 910348003617 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 910348003618 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 910348003619 TM-ABC transporter signature motif; other site 910348003620 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 910348003621 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 910348003622 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 910348003623 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 910348003624 active site 910348003625 homotetramer interface [polypeptide binding]; other site 910348003626 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 910348003627 Ligand Binding Site [chemical binding]; other site 910348003628 transcriptional activator FlhD; Provisional; Region: PRK02909 910348003629 transcriptional activator FlhC; Provisional; Region: PRK12722 910348003630 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 910348003631 flagellar motor protein MotA; Validated; Region: PRK09110 910348003632 flagellar motor protein MotB; Validated; Region: motB; PRK09041 910348003633 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 910348003634 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 910348003635 ligand binding site [chemical binding]; other site 910348003636 chemotaxis protein CheA; Provisional; Region: PRK10547 910348003637 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 910348003638 putative binding surface; other site 910348003639 active site 910348003640 CheY binding; Region: CheY-binding; pfam09078 910348003641 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 910348003642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348003643 ATP binding site [chemical binding]; other site 910348003644 Mg2+ binding site [ion binding]; other site 910348003645 G-X-G motif; other site 910348003646 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 910348003647 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 910348003648 putative CheA interaction surface; other site 910348003649 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 910348003650 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 910348003651 dimer interface [polypeptide binding]; other site 910348003652 ligand binding site [chemical binding]; other site 910348003653 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 910348003654 dimerization interface [polypeptide binding]; other site 910348003655 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 910348003656 dimer interface [polypeptide binding]; other site 910348003657 putative CheW interface [polypeptide binding]; other site 910348003658 methyl-accepting protein IV; Provisional; Region: PRK09793 910348003659 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 910348003660 dimer interface [polypeptide binding]; other site 910348003661 ligand binding site [chemical binding]; other site 910348003662 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 910348003663 dimerization interface [polypeptide binding]; other site 910348003664 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 910348003665 dimer interface [polypeptide binding]; other site 910348003666 putative CheW interface [polypeptide binding]; other site 910348003667 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 910348003668 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 910348003669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348003670 S-adenosylmethionine binding site [chemical binding]; other site 910348003671 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 910348003672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348003673 active site 910348003674 phosphorylation site [posttranslational modification] 910348003675 intermolecular recognition site; other site 910348003676 dimerization interface [polypeptide binding]; other site 910348003677 CheB methylesterase; Region: CheB_methylest; pfam01339 910348003678 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 910348003679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348003680 active site 910348003681 phosphorylation site [posttranslational modification] 910348003682 intermolecular recognition site; other site 910348003683 dimerization interface [polypeptide binding]; other site 910348003684 chemotaxis regulator CheZ; Provisional; Region: PRK11166 910348003685 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 910348003686 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 910348003687 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 910348003688 FHIPEP family; Region: FHIPEP; pfam00771 910348003689 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 910348003690 arginyl-tRNA synthetase; Region: argS; TIGR00456 910348003691 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 910348003692 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 910348003693 active site 910348003694 HIGH motif; other site 910348003695 KMSK motif region; other site 910348003696 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 910348003697 tRNA binding surface [nucleotide binding]; other site 910348003698 anticodon binding site; other site 910348003699 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 910348003700 putative metal binding site [ion binding]; other site 910348003701 copper homeostasis protein CutC; Provisional; Region: PRK11572 910348003702 Transposase domain (DUF772); Region: DUF772; pfam05598 910348003703 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 910348003704 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 910348003705 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 910348003706 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 910348003707 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 910348003708 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 910348003709 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 910348003710 molybdopterin cofactor binding site [chemical binding]; other site 910348003711 substrate binding site [chemical binding]; other site 910348003712 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 910348003713 molybdopterin cofactor binding site; other site 910348003714 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348003715 S-adenosylmethionine binding site [chemical binding]; other site 910348003716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348003717 S-adenosylmethionine binding site [chemical binding]; other site 910348003718 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 910348003719 hypothetical protein; Provisional; Region: PRK10302 910348003720 Isochorismatase family; Region: Isochorismatase; pfam00857 910348003721 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 910348003722 catalytic triad [active] 910348003723 conserved cis-peptide bond; other site 910348003724 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 910348003725 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 910348003726 dimer interface [polypeptide binding]; other site 910348003727 anticodon binding site; other site 910348003728 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 910348003729 homodimer interface [polypeptide binding]; other site 910348003730 motif 1; other site 910348003731 active site 910348003732 motif 2; other site 910348003733 GAD domain; Region: GAD; pfam02938 910348003734 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 910348003735 active site 910348003736 motif 3; other site 910348003737 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 910348003738 nudix motif; other site 910348003739 hypothetical protein; Validated; Region: PRK00110 910348003740 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 910348003741 active site 910348003742 putative DNA-binding cleft [nucleotide binding]; other site 910348003743 dimer interface [polypeptide binding]; other site 910348003744 hypothetical protein; Provisional; Region: PRK11470 910348003745 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 910348003746 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348003747 Walker A motif; other site 910348003748 ATP binding site [chemical binding]; other site 910348003749 Walker B motif; other site 910348003750 arginine finger; other site 910348003751 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 910348003752 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 910348003753 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 910348003754 ABC-ATPase subunit interface; other site 910348003755 dimer interface [polypeptide binding]; other site 910348003756 putative PBP binding regions; other site 910348003757 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 910348003758 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 910348003759 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 910348003760 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 910348003761 metal binding site [ion binding]; metal-binding site 910348003762 putative peptidase; Provisional; Region: PRK11649 910348003763 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 910348003764 Peptidase family M23; Region: Peptidase_M23; pfam01551 910348003765 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 910348003766 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 910348003767 putative acyl-acceptor binding pocket; other site 910348003768 pyruvate kinase; Provisional; Region: PRK05826 910348003769 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 910348003770 domain interfaces; other site 910348003771 active site 910348003772 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 910348003773 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 910348003774 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 910348003775 putative active site [active] 910348003776 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 910348003777 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 910348003778 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 910348003779 phosphogluconate dehydratase; Validated; Region: PRK09054 910348003780 6-phosphogluconate dehydratase; Region: edd; TIGR01196 910348003781 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 910348003782 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 910348003783 active site 910348003784 intersubunit interface [polypeptide binding]; other site 910348003785 catalytic residue [active] 910348003786 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 910348003787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 910348003788 ATP-grasp domain; Region: ATP-grasp; pfam02222 910348003789 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 910348003790 hypothetical protein; Provisional; Region: PRK13680 910348003791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 910348003792 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 910348003793 putative metal binding site [ion binding]; other site 910348003794 protease 2; Provisional; Region: PRK10115 910348003795 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 910348003796 exodeoxyribonuclease X; Provisional; Region: PRK07983 910348003797 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 910348003798 active site 910348003799 catalytic site [active] 910348003800 substrate binding site [chemical binding]; other site 910348003801 Predicted amidohydrolase [General function prediction only]; Region: COG0388 910348003802 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 910348003803 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 910348003804 hypothetical protein; Provisional; Region: PRK10301 910348003805 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 910348003806 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 910348003807 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 910348003808 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 910348003809 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 910348003810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348003811 S-adenosylmethionine binding site [chemical binding]; other site 910348003812 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 910348003813 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 910348003814 mce related protein; Region: MCE; pfam02470 910348003815 mce related protein; Region: MCE; pfam02470 910348003816 mce related protein; Region: MCE; pfam02470 910348003817 mce related protein; Region: MCE; pfam02470 910348003818 mce related protein; Region: MCE; pfam02470 910348003819 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 910348003820 Paraquat-inducible protein A; Region: PqiA; pfam04403 910348003821 Paraquat-inducible protein A; Region: PqiA; pfam04403 910348003822 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 910348003823 GAF domain; Region: GAF_2; pfam13185 910348003824 ProP expression regulator; Provisional; Region: PRK04950 910348003825 ProQ/FINO family; Region: ProQ; pfam04352 910348003826 carboxy-terminal protease; Provisional; Region: PRK11186 910348003827 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 910348003828 protein binding site [polypeptide binding]; other site 910348003829 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 910348003830 Catalytic dyad [active] 910348003831 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 910348003832 heat shock protein HtpX; Provisional; Region: PRK05457 910348003833 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 910348003834 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 910348003835 dimerization interface [polypeptide binding]; other site 910348003836 putative Zn2+ binding site [ion binding]; other site 910348003837 putative DNA binding site [nucleotide binding]; other site 910348003838 Bacterial transcriptional regulator; Region: IclR; pfam01614 910348003839 PhoPQ regulatory protein; Provisional; Region: PRK10299 910348003840 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 910348003841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348003842 S-adenosylmethionine binding site [chemical binding]; other site 910348003843 hypothetical protein; Provisional; Region: PRK11469 910348003844 Domain of unknown function DUF; Region: DUF204; pfam02659 910348003845 Domain of unknown function DUF; Region: DUF204; pfam02659 910348003846 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348003847 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 910348003848 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 910348003849 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 910348003850 Predicted membrane protein [Function unknown]; Region: COG4811 910348003851 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 910348003852 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 910348003853 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 910348003854 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 910348003855 active pocket/dimerization site; other site 910348003856 active site 910348003857 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 910348003858 active site 910348003859 phosphorylation site [posttranslational modification] 910348003860 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 910348003861 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 910348003862 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 910348003863 Transporter associated domain; Region: CorC_HlyC; smart01091 910348003864 phage resistance protein; Provisional; Region: PRK10551 910348003865 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 910348003866 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 910348003867 L-serine deaminase; Provisional; Region: PRK15023 910348003868 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 910348003869 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 910348003870 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 910348003871 putative active site [active] 910348003872 putative CoA binding site [chemical binding]; other site 910348003873 nudix motif; other site 910348003874 metal binding site [ion binding]; metal-binding site 910348003875 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 910348003876 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 910348003877 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 910348003878 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 910348003879 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 910348003880 DEAD/DEAH box helicase; Region: DEAD; pfam00270 910348003881 DEAD_2; Region: DEAD_2; pfam06733 910348003882 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 910348003883 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 910348003884 Glycoprotease family; Region: Peptidase_M22; pfam00814 910348003885 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 910348003886 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 910348003887 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 910348003888 acyl-activating enzyme (AAE) consensus motif; other site 910348003889 putative AMP binding site [chemical binding]; other site 910348003890 putative active site [active] 910348003891 putative CoA binding site [chemical binding]; other site 910348003892 ribonuclease D; Provisional; Region: PRK10829 910348003893 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 910348003894 catalytic site [active] 910348003895 putative active site [active] 910348003896 putative substrate binding site [chemical binding]; other site 910348003897 Helicase and RNase D C-terminal; Region: HRDC; smart00341 910348003898 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 910348003899 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 910348003900 FMN-binding pocket [chemical binding]; other site 910348003901 flavin binding motif; other site 910348003902 phosphate binding motif [ion binding]; other site 910348003903 beta-alpha-beta structure motif; other site 910348003904 NAD binding pocket [chemical binding]; other site 910348003905 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 910348003906 catalytic loop [active] 910348003907 iron binding site [ion binding]; other site 910348003908 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 910348003909 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 910348003910 [2Fe-2S] cluster binding site [ion binding]; other site 910348003911 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 910348003912 putative alpha subunit interface [polypeptide binding]; other site 910348003913 putative active site [active] 910348003914 putative substrate binding site [chemical binding]; other site 910348003915 Fe binding site [ion binding]; other site 910348003916 putative transporter; Provisional; Region: PRK09950 910348003917 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 910348003918 tartrate dehydrogenase; Region: TTC; TIGR02089 910348003919 transcriptional activator TtdR; Provisional; Region: PRK09801 910348003920 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348003921 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 910348003922 putative effector binding pocket; other site 910348003923 putative dimerization interface [polypeptide binding]; other site 910348003924 leucine export protein LeuE; Provisional; Region: PRK10958 910348003925 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 910348003926 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 910348003927 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 910348003928 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 910348003929 metal binding site [ion binding]; metal-binding site 910348003930 active site 910348003931 I-site; other site 910348003932 Uncharacterized conserved protein [Function unknown]; Region: COG3189 910348003933 cyanate transporter; Region: CynX; TIGR00896 910348003934 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348003935 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 910348003936 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348003937 Predicted membrane protein [Function unknown]; Region: COG2707 910348003938 Transposase domain (DUF772); Region: DUF772; pfam05598 910348003939 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 910348003940 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 910348003941 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 910348003942 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 910348003943 metal binding site [ion binding]; metal-binding site 910348003944 active site 910348003945 I-site; other site 910348003946 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348003947 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 910348003948 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 910348003949 metal binding site [ion binding]; metal-binding site 910348003950 active site 910348003951 I-site; other site 910348003952 hypothetical protein; Provisional; Region: PRK05325 910348003953 PrkA family serine protein kinase; Provisional; Region: PRK15455 910348003954 AAA ATPase domain; Region: AAA_16; pfam13191 910348003955 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 910348003956 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 910348003957 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 910348003958 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 910348003959 active site 910348003960 catalytic tetrad [active] 910348003961 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 910348003962 active site 910348003963 phosphate binding residues; other site 910348003964 catalytic residues [active] 910348003965 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 910348003966 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 910348003967 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 910348003968 methionine sulfoxide reductase B; Provisional; Region: PRK00222 910348003969 SelR domain; Region: SelR; pfam01641 910348003970 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 910348003971 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 910348003972 putative NAD(P) binding site [chemical binding]; other site 910348003973 catalytic Zn binding site [ion binding]; other site 910348003974 structural Zn binding site [ion binding]; other site 910348003975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348003976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348003977 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 910348003978 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 910348003979 inhibitor binding site; inhibition site 910348003980 catalytic Zn binding site [ion binding]; other site 910348003981 structural Zn binding site [ion binding]; other site 910348003982 NADP binding site [chemical binding]; other site 910348003983 tetramer interface [polypeptide binding]; other site 910348003984 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 910348003985 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 910348003986 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 910348003987 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 910348003988 intersubunit interface [polypeptide binding]; other site 910348003989 active site 910348003990 zinc binding site [ion binding]; other site 910348003991 Na+ binding site [ion binding]; other site 910348003992 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 910348003993 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 910348003994 substrate binding site [chemical binding]; other site 910348003995 ATP binding site [chemical binding]; other site 910348003996 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 910348003997 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 910348003998 active site 910348003999 catalytic tetrad [active] 910348004000 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 910348004001 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 910348004002 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 910348004003 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 910348004004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348004005 putative substrate translocation pore; other site 910348004006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348004007 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 910348004008 Isochorismatase family; Region: Isochorismatase; pfam00857 910348004009 catalytic triad [active] 910348004010 metal binding site [ion binding]; metal-binding site 910348004011 conserved cis-peptide bond; other site 910348004012 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 910348004013 homodimer interface [polypeptide binding]; other site 910348004014 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 910348004015 protease 4; Provisional; Region: PRK10949 910348004016 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 910348004017 tandem repeat interface [polypeptide binding]; other site 910348004018 oligomer interface [polypeptide binding]; other site 910348004019 active site residues [active] 910348004020 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 910348004021 tandem repeat interface [polypeptide binding]; other site 910348004022 oligomer interface [polypeptide binding]; other site 910348004023 active site residues [active] 910348004024 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 910348004025 dimer interface [polypeptide binding]; other site 910348004026 selenophosphate synthetase; Provisional; Region: PRK00943 910348004027 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 910348004028 dimerization interface [polypeptide binding]; other site 910348004029 putative ATP binding site [chemical binding]; other site 910348004030 DNA topoisomerase III; Provisional; Region: PRK07726 910348004031 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 910348004032 active site 910348004033 putative interdomain interaction site [polypeptide binding]; other site 910348004034 putative metal-binding site [ion binding]; other site 910348004035 putative nucleotide binding site [chemical binding]; other site 910348004036 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 910348004037 domain I; other site 910348004038 DNA binding groove [nucleotide binding] 910348004039 phosphate binding site [ion binding]; other site 910348004040 domain II; other site 910348004041 domain III; other site 910348004042 nucleotide binding site [chemical binding]; other site 910348004043 catalytic site [active] 910348004044 domain IV; other site 910348004045 hypothetical protein; Provisional; Region: PRK11380 910348004046 glutamate dehydrogenase; Provisional; Region: PRK09414 910348004047 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 910348004048 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 910348004049 NAD(P) binding site [chemical binding]; other site 910348004050 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 910348004051 active site 910348004052 8-oxo-dGMP binding site [chemical binding]; other site 910348004053 nudix motif; other site 910348004054 metal binding site [ion binding]; metal-binding site 910348004055 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 910348004056 Rhodanese Homology Domain; Region: RHOD; smart00450 910348004057 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 910348004058 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 910348004059 active site residue [active] 910348004060 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 910348004061 active site residue [active] 910348004062 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 910348004063 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 910348004064 Walker A/P-loop; other site 910348004065 ATP binding site [chemical binding]; other site 910348004066 Q-loop/lid; other site 910348004067 ABC transporter signature motif; other site 910348004068 Walker B; other site 910348004069 D-loop; other site 910348004070 H-loop/switch region; other site 910348004071 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 910348004072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348004073 dimer interface [polypeptide binding]; other site 910348004074 conserved gate region; other site 910348004075 putative PBP binding loops; other site 910348004076 ABC-ATPase subunit interface; other site 910348004077 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 910348004078 hypothetical protein; Provisional; Region: PRK11622 910348004079 Uncharacterized conserved protein [Function unknown]; Region: COG2128 910348004080 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 910348004081 Uncharacterized conserved protein [Function unknown]; Region: COG0398 910348004082 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 910348004083 Uncharacterized conserved protein [Function unknown]; Region: COG0398 910348004084 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 910348004085 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 910348004086 putative catalytic site [active] 910348004087 putative phosphate binding site [ion binding]; other site 910348004088 active site 910348004089 metal binding site A [ion binding]; metal-binding site 910348004090 DNA binding site [nucleotide binding] 910348004091 putative AP binding site [nucleotide binding]; other site 910348004092 putative metal binding site B [ion binding]; other site 910348004093 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 910348004094 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 910348004095 inhibitor-cofactor binding pocket; inhibition site 910348004096 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348004097 catalytic residue [active] 910348004098 arginine succinyltransferase; Provisional; Region: PRK10456 910348004099 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 910348004100 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 910348004101 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 910348004102 NAD(P) binding site [chemical binding]; other site 910348004103 catalytic residues [active] 910348004104 succinylarginine dihydrolase; Provisional; Region: PRK13281 910348004105 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 910348004106 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 910348004107 putative active site [active] 910348004108 Zn binding site [ion binding]; other site 910348004109 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 910348004110 dimer interface [polypeptide binding]; other site 910348004111 hypothetical protein; Provisional; Region: PRK11396 910348004112 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 910348004113 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 910348004114 active site 910348004115 catalytic site [active] 910348004116 putative DNA binding site [nucleotide binding]; other site 910348004117 GIY-YIG motif/motif A; other site 910348004118 metal binding site [ion binding]; metal-binding site 910348004119 NAD+ synthetase; Region: nadE; TIGR00552 910348004120 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 910348004121 homodimer interface [polypeptide binding]; other site 910348004122 NAD binding pocket [chemical binding]; other site 910348004123 ATP binding pocket [chemical binding]; other site 910348004124 Mg binding site [ion binding]; other site 910348004125 active-site loop [active] 910348004126 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 910348004127 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 910348004128 active site 910348004129 P-loop; other site 910348004130 phosphorylation site [posttranslational modification] 910348004131 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 910348004132 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 910348004133 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 910348004134 methionine cluster; other site 910348004135 active site 910348004136 phosphorylation site [posttranslational modification] 910348004137 metal binding site [ion binding]; metal-binding site 910348004138 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 910348004139 Cupin domain; Region: Cupin_2; pfam07883 910348004140 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348004141 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 910348004142 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 910348004143 NAD binding site [chemical binding]; other site 910348004144 sugar binding site [chemical binding]; other site 910348004145 divalent metal binding site [ion binding]; other site 910348004146 tetramer (dimer of dimers) interface [polypeptide binding]; other site 910348004147 dimer interface [polypeptide binding]; other site 910348004148 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 910348004149 putative active site [active] 910348004150 YdjC motif; other site 910348004151 Mg binding site [ion binding]; other site 910348004152 putative homodimer interface [polypeptide binding]; other site 910348004153 hydroperoxidase II; Provisional; Region: katE; PRK11249 910348004154 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 910348004155 tetramer interface [polypeptide binding]; other site 910348004156 heme binding pocket [chemical binding]; other site 910348004157 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 910348004158 domain interactions; other site 910348004159 cell division modulator; Provisional; Region: PRK10113 910348004160 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 910348004161 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 910348004162 inner membrane protein; Provisional; Region: PRK11648 910348004163 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 910348004164 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 910348004165 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 910348004166 motif II; other site 910348004167 YniB-like protein; Region: YniB; pfam14002 910348004168 Phosphotransferase enzyme family; Region: APH; pfam01636 910348004169 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 910348004170 active site 910348004171 ATP binding site [chemical binding]; other site 910348004172 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 910348004173 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 910348004174 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 910348004175 putative substrate binding site [chemical binding]; other site 910348004176 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 910348004177 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 910348004178 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 910348004179 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 910348004180 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 910348004181 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 910348004182 active site 910348004183 dimer interface [polypeptide binding]; other site 910348004184 motif 1; other site 910348004185 motif 2; other site 910348004186 motif 3; other site 910348004187 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 910348004188 anticodon binding site; other site 910348004189 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 910348004190 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 910348004191 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 910348004192 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 910348004193 23S rRNA binding site [nucleotide binding]; other site 910348004194 L21 binding site [polypeptide binding]; other site 910348004195 L13 binding site [polypeptide binding]; other site 910348004196 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 910348004197 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 910348004198 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 910348004199 dimer interface [polypeptide binding]; other site 910348004200 motif 1; other site 910348004201 active site 910348004202 motif 2; other site 910348004203 motif 3; other site 910348004204 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 910348004205 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 910348004206 putative tRNA-binding site [nucleotide binding]; other site 910348004207 B3/4 domain; Region: B3_4; pfam03483 910348004208 tRNA synthetase B5 domain; Region: B5; smart00874 910348004209 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 910348004210 dimer interface [polypeptide binding]; other site 910348004211 motif 1; other site 910348004212 motif 3; other site 910348004213 motif 2; other site 910348004214 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 910348004215 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 910348004216 IHF dimer interface [polypeptide binding]; other site 910348004217 IHF - DNA interface [nucleotide binding]; other site 910348004218 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 910348004219 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 910348004220 ABC-ATPase subunit interface; other site 910348004221 dimer interface [polypeptide binding]; other site 910348004222 putative PBP binding regions; other site 910348004223 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 910348004224 catalytic residues [active] 910348004225 dimer interface [polypeptide binding]; other site 910348004226 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 910348004227 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 910348004228 Walker A/P-loop; other site 910348004229 ATP binding site [chemical binding]; other site 910348004230 Q-loop/lid; other site 910348004231 ABC transporter signature motif; other site 910348004232 Walker B; other site 910348004233 D-loop; other site 910348004234 H-loop/switch region; other site 910348004235 NlpC/P60 family; Region: NLPC_P60; pfam00877 910348004236 Helix-turn-helix domain; Region: HTH_28; pfam13518 910348004237 Winged helix-turn helix; Region: HTH_29; pfam13551 910348004238 Homeodomain-like domain; Region: HTH_32; pfam13565 910348004239 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 910348004240 DDE superfamily endonuclease; Region: DDE_3; pfam13358 910348004241 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 910348004242 Uncharacterized conserved protein [Function unknown]; Region: COG0397 910348004243 hypothetical protein; Validated; Region: PRK00029 910348004244 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 910348004245 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 910348004246 PEP synthetase regulatory protein; Provisional; Region: PRK05339 910348004247 phosphoenolpyruvate synthase; Validated; Region: PRK06464 910348004248 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 910348004249 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 910348004250 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 910348004251 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 910348004252 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 910348004253 acyl-activating enzyme (AAE) consensus motif; other site 910348004254 putative AMP binding site [chemical binding]; other site 910348004255 putative active site [active] 910348004256 putative CoA binding site [chemical binding]; other site 910348004257 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 910348004258 oxidoreductase; Provisional; Region: PRK10015 910348004259 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 910348004260 Electron transfer flavoprotein domain; Region: ETF; smart00893 910348004261 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 910348004262 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 910348004263 Ligand binding site [chemical binding]; other site 910348004264 Electron transfer flavoprotein domain; Region: ETF; pfam01012 910348004265 Cupin domain; Region: Cupin_2; pfam07883 910348004266 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 910348004267 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 910348004268 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348004269 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 910348004270 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 910348004271 active site 910348004272 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 910348004273 Coenzyme A transferase; Region: CoA_trans; smart00882 910348004274 Coenzyme A transferase; Region: CoA_trans; cl17247 910348004275 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 910348004276 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 910348004277 active site 910348004278 catalytic residue [active] 910348004279 dimer interface [polypeptide binding]; other site 910348004280 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 910348004281 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 910348004282 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 910348004283 shikimate binding site; other site 910348004284 NAD(P) binding site [chemical binding]; other site 910348004285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348004286 Major Facilitator Superfamily; Region: MFS_1; pfam07690 910348004287 putative substrate translocation pore; other site 910348004288 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 910348004289 putative inner membrane protein; Provisional; Region: PRK10983 910348004290 Domain of unknown function DUF20; Region: UPF0118; pfam01594 910348004291 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 910348004292 FAD binding domain; Region: FAD_binding_4; pfam01565 910348004293 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 910348004294 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 910348004295 CoenzymeA binding site [chemical binding]; other site 910348004296 subunit interaction site [polypeptide binding]; other site 910348004297 PHB binding site; other site 910348004298 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 910348004299 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 910348004300 putative ABC transporter; Region: ycf24; CHL00085 910348004301 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 910348004302 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 910348004303 Walker A/P-loop; other site 910348004304 ATP binding site [chemical binding]; other site 910348004305 Q-loop/lid; other site 910348004306 ABC transporter signature motif; other site 910348004307 Walker B; other site 910348004308 D-loop; other site 910348004309 H-loop/switch region; other site 910348004310 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 910348004311 FeS assembly protein SufD; Region: sufD; TIGR01981 910348004312 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 910348004313 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 910348004314 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 910348004315 catalytic residue [active] 910348004316 cysteine desufuration protein SufE; Provisional; Region: PRK09296 910348004317 L,D-transpeptidase; Provisional; Region: PRK10190 910348004318 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 910348004319 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 910348004320 murein lipoprotein; Provisional; Region: PRK15396 910348004321 pyruvate kinase; Provisional; Region: PRK09206 910348004322 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 910348004323 active site 910348004324 domain interfaces; other site 910348004325 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348004326 4Fe-4S binding domain; Region: Fer4; cl02805 910348004327 putative oxidoreductase; Provisional; Region: PRK09849 910348004328 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 910348004329 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 910348004330 hypothetical protein; Provisional; Region: PRK09947 910348004331 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 910348004332 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 910348004333 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 910348004334 hypothetical protein; Provisional; Region: PRK09946 910348004335 hypothetical protein; Provisional; Region: PRK09897 910348004336 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 910348004337 putative monooxygenase; Provisional; Region: PRK11118 910348004338 hypothetical protein; Provisional; Region: PRK09945 910348004339 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 910348004340 multidrug efflux protein; Reviewed; Region: PRK01766 910348004341 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 910348004342 cation binding site [ion binding]; other site 910348004343 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 910348004344 Lumazine binding domain; Region: Lum_binding; pfam00677 910348004345 Lumazine binding domain; Region: Lum_binding; pfam00677 910348004346 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 910348004347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 910348004348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348004349 S-adenosylmethionine binding site [chemical binding]; other site 910348004350 putative transporter; Provisional; Region: PRK11043 910348004351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348004352 putative substrate translocation pore; other site 910348004353 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 910348004354 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348004355 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 910348004356 dimerization interface [polypeptide binding]; other site 910348004357 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 910348004358 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 910348004359 DNA binding site [nucleotide binding] 910348004360 domain linker motif; other site 910348004361 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 910348004362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348004363 Major Facilitator Superfamily; Region: MFS_1; pfam07690 910348004364 putative substrate translocation pore; other site 910348004365 superoxide dismutase; Provisional; Region: PRK10543 910348004366 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 910348004367 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 910348004368 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 910348004369 NlpC/P60 family; Region: NLPC_P60; pfam00877 910348004370 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 910348004371 putative GSH binding site [chemical binding]; other site 910348004372 catalytic residues [active] 910348004373 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 910348004374 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 910348004375 dimer interface [polypeptide binding]; other site 910348004376 catalytic site [active] 910348004377 putative active site [active] 910348004378 putative substrate binding site [chemical binding]; other site 910348004379 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 910348004380 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 910348004381 dimer interface [polypeptide binding]; other site 910348004382 active site 910348004383 metal binding site [ion binding]; metal-binding site 910348004384 glutathione binding site [chemical binding]; other site 910348004385 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 910348004386 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 910348004387 FMN binding site [chemical binding]; other site 910348004388 active site 910348004389 substrate binding site [chemical binding]; other site 910348004390 catalytic residue [active] 910348004391 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 910348004392 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 910348004393 Predicted Fe-S protein [General function prediction only]; Region: COG3313 910348004394 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 910348004395 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 910348004396 active site 910348004397 catalytic tetrad [active] 910348004398 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 910348004399 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 910348004400 E-class dimer interface [polypeptide binding]; other site 910348004401 P-class dimer interface [polypeptide binding]; other site 910348004402 active site 910348004403 Cu2+ binding site [ion binding]; other site 910348004404 Zn2+ binding site [ion binding]; other site 910348004405 Fusaric acid resistance protein family; Region: FUSC; pfam04632 910348004406 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 910348004407 transcriptional regulator SlyA; Provisional; Region: PRK03573 910348004408 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 910348004409 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 910348004410 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 910348004411 lysozyme inhibitor; Provisional; Region: PRK11372 910348004412 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 910348004413 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 910348004414 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 910348004415 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 910348004416 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 910348004417 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 910348004418 active site 910348004419 HIGH motif; other site 910348004420 dimer interface [polypeptide binding]; other site 910348004421 KMSKS motif; other site 910348004422 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 910348004423 RNA binding surface [nucleotide binding]; other site 910348004424 pyridoxamine kinase; Validated; Region: PRK05756 910348004425 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 910348004426 dimer interface [polypeptide binding]; other site 910348004427 pyridoxal binding site [chemical binding]; other site 910348004428 ATP binding site [chemical binding]; other site 910348004429 glutathionine S-transferase; Provisional; Region: PRK10542 910348004430 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 910348004431 C-terminal domain interface [polypeptide binding]; other site 910348004432 GSH binding site (G-site) [chemical binding]; other site 910348004433 dimer interface [polypeptide binding]; other site 910348004434 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 910348004435 N-terminal domain interface [polypeptide binding]; other site 910348004436 dimer interface [polypeptide binding]; other site 910348004437 substrate binding pocket (H-site) [chemical binding]; other site 910348004438 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 910348004439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348004440 endonuclease III; Provisional; Region: PRK10702 910348004441 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 910348004442 minor groove reading motif; other site 910348004443 helix-hairpin-helix signature motif; other site 910348004444 substrate binding pocket [chemical binding]; other site 910348004445 active site 910348004446 electron transport complex RsxE subunit; Provisional; Region: PRK12405 910348004447 electron transport complex protein RnfG; Validated; Region: PRK01908 910348004448 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 910348004449 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 910348004450 SLBB domain; Region: SLBB; pfam10531 910348004451 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 910348004452 electron transport complex protein RnfB; Provisional; Region: PRK05113 910348004453 Putative Fe-S cluster; Region: FeS; pfam04060 910348004454 4Fe-4S binding domain; Region: Fer4; pfam00037 910348004455 electron transport complex protein RsxA; Provisional; Region: PRK05151 910348004456 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 910348004457 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 910348004458 putative oxidoreductase; Provisional; Region: PRK11579 910348004459 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 910348004460 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 910348004461 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 910348004462 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 910348004463 active site 910348004464 purine riboside binding site [chemical binding]; other site 910348004465 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 910348004466 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 910348004467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348004468 homodimer interface [polypeptide binding]; other site 910348004469 catalytic residue [active] 910348004470 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 910348004471 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 910348004472 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 910348004473 active site turn [active] 910348004474 phosphorylation site [posttranslational modification] 910348004475 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 910348004476 DNA binding site [nucleotide binding] 910348004477 domain linker motif; other site 910348004478 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 910348004479 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 910348004480 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 910348004481 NAD binding site [chemical binding]; other site 910348004482 substrate binding site [chemical binding]; other site 910348004483 homotetramer interface [polypeptide binding]; other site 910348004484 homodimer interface [polypeptide binding]; other site 910348004485 active site 910348004486 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 910348004487 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 910348004488 beta-D-glucuronidase; Provisional; Region: PRK10150 910348004489 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 910348004490 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 910348004491 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 910348004492 glucuronide transporter; Provisional; Region: PRK09848 910348004493 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 910348004494 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348004495 putative outer membrane porin protein; Provisional; Region: PRK11379 910348004496 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 910348004497 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 910348004498 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 910348004499 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 910348004500 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 910348004501 fumarate hydratase; Provisional; Region: PRK15389 910348004502 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 910348004503 Fumarase C-terminus; Region: Fumerase_C; pfam05683 910348004504 fumarate hydratase; Reviewed; Region: fumC; PRK00485 910348004505 Class II fumarases; Region: Fumarase_classII; cd01362 910348004506 active site 910348004507 tetramer interface [polypeptide binding]; other site 910348004508 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 910348004509 sensor protein RstB; Provisional; Region: PRK10604 910348004510 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 910348004511 dimerization interface [polypeptide binding]; other site 910348004512 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 910348004513 dimer interface [polypeptide binding]; other site 910348004514 phosphorylation site [posttranslational modification] 910348004515 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348004516 ATP binding site [chemical binding]; other site 910348004517 Mg2+ binding site [ion binding]; other site 910348004518 G-X-G motif; other site 910348004519 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 910348004520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348004521 active site 910348004522 phosphorylation site [posttranslational modification] 910348004523 intermolecular recognition site; other site 910348004524 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 910348004525 DNA binding site [nucleotide binding] 910348004526 dihydromonapterin reductase; Provisional; Region: PRK06483 910348004527 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 910348004528 NADP binding site [chemical binding]; other site 910348004529 substrate binding pocket [chemical binding]; other site 910348004530 active site 910348004531 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 910348004532 Spore germination protein; Region: Spore_permease; cl17796 910348004533 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 910348004534 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 910348004535 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 910348004536 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 910348004537 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 910348004538 ligand binding site [chemical binding]; other site 910348004539 homodimer interface [polypeptide binding]; other site 910348004540 NAD(P) binding site [chemical binding]; other site 910348004541 trimer interface B [polypeptide binding]; other site 910348004542 trimer interface A [polypeptide binding]; other site 910348004543 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 910348004544 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 910348004545 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 910348004546 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 910348004547 Domain of unknown function DUF20; Region: UPF0118; pfam01594 910348004548 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 910348004549 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 910348004550 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 910348004551 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 910348004552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348004553 putative substrate translocation pore; other site 910348004554 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 910348004555 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348004556 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 910348004557 dimerization interface [polypeptide binding]; other site 910348004558 substrate binding pocket [chemical binding]; other site 910348004559 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 910348004560 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 910348004561 nucleotide binding site [chemical binding]; other site 910348004562 putative dithiobiotin synthetase; Provisional; Region: PRK12374 910348004563 AAA domain; Region: AAA_26; pfam13500 910348004564 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 910348004565 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 910348004566 Cl- selectivity filter; other site 910348004567 Cl- binding residues [ion binding]; other site 910348004568 pore gating glutamate residue; other site 910348004569 dimer interface [polypeptide binding]; other site 910348004570 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 910348004571 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 910348004572 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 910348004573 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 910348004574 putative [Fe4-S4] binding site [ion binding]; other site 910348004575 putative molybdopterin cofactor binding site [chemical binding]; other site 910348004576 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 910348004577 putative molybdopterin cofactor binding site; other site 910348004578 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 910348004579 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 910348004580 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 910348004581 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 910348004582 Coenzyme A binding pocket [chemical binding]; other site 910348004583 hypothetical protein; Provisional; Region: PRK13659 910348004584 hypothetical protein; Provisional; Region: PRK02237 910348004585 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 910348004586 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 910348004587 putative active site pocket [active] 910348004588 putative metal binding site [ion binding]; other site 910348004589 putative oxidoreductase; Provisional; Region: PRK10083 910348004590 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 910348004591 putative NAD(P) binding site [chemical binding]; other site 910348004592 catalytic Zn binding site [ion binding]; other site 910348004593 structural Zn binding site [ion binding]; other site 910348004594 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 910348004595 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 910348004596 active site 910348004597 catalytic site [active] 910348004598 substrate binding site [chemical binding]; other site 910348004599 Methyltransferase domain; Region: Methyltransf_25; pfam13649 910348004600 Homeodomain-like domain; Region: HTH_23; pfam13384 910348004601 Winged helix-turn helix; Region: HTH_29; pfam13551 910348004602 Homeodomain-like domain; Region: HTH_32; pfam13565 910348004603 Integrase core domain; Region: rve; pfam00665 910348004604 Integrase core domain; Region: rve_3; cl15866 910348004605 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 910348004606 Protein of unknown function (DUF433); Region: DUF433; cl01030 910348004607 MULE transposase domain; Region: MULE; pfam10551 910348004608 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 910348004609 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 910348004610 Hok/gef family; Region: HOK_GEF; pfam01848 910348004611 Protein of unknown function (DUF968); Region: DUF968; pfam06147 910348004612 Antitermination protein; Region: Antiterm; pfam03589 910348004613 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 910348004614 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 910348004615 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 910348004616 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 910348004617 DNA-binding site [nucleotide binding]; DNA binding site 910348004618 RNA-binding motif; other site 910348004619 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 910348004620 DNA-binding site [nucleotide binding]; DNA binding site 910348004621 RNA-binding motif; other site 910348004622 Lysis protein S; Region: Lysis_S; pfam04971 910348004623 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 910348004624 catalytic residues [active] 910348004625 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 910348004626 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 910348004627 DNA-binding site [nucleotide binding]; DNA binding site 910348004628 RNA-binding motif; other site 910348004629 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 910348004630 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 910348004631 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 910348004632 Phage-related protein [Function unknown]; Region: gp18; COG4672 910348004633 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 910348004634 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 910348004635 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 910348004636 NlpC/P60 family; Region: NLPC_P60; cl17555 910348004637 multiple promoter invertase; Provisional; Region: mpi; PRK13413 910348004638 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 910348004639 catalytic residues [active] 910348004640 catalytic nucleophile [active] 910348004641 Presynaptic Site I dimer interface [polypeptide binding]; other site 910348004642 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 910348004643 Synaptic Flat tetramer interface [polypeptide binding]; other site 910348004644 Synaptic Site I dimer interface [polypeptide binding]; other site 910348004645 DNA binding site [nucleotide binding] 910348004646 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 910348004647 DNA-binding interface [nucleotide binding]; DNA binding site 910348004648 metabolite-proton symporter; Region: 2A0106; TIGR00883 910348004649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348004650 putative substrate translocation pore; other site 910348004651 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 910348004652 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 910348004653 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 910348004654 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 910348004655 Transcriptional regulators [Transcription]; Region: GntR; COG1802 910348004656 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 910348004657 DNA-binding site [nucleotide binding]; DNA binding site 910348004658 FCD domain; Region: FCD; pfam07729 910348004659 malonic semialdehyde reductase; Provisional; Region: PRK10538 910348004660 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 910348004661 putative NAD(P) binding site [chemical binding]; other site 910348004662 homodimer interface [polypeptide binding]; other site 910348004663 homotetramer interface [polypeptide binding]; other site 910348004664 active site 910348004665 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 910348004666 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 910348004667 active site 910348004668 Zn binding site [ion binding]; other site 910348004669 Competence-damaged protein; Region: CinA; cl00666 910348004670 hypothetical protein; Provisional; Region: PRK10053 910348004671 diguanylate cyclase; Provisional; Region: PRK09894 910348004672 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 910348004673 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 910348004674 metal binding site [ion binding]; metal-binding site 910348004675 active site 910348004676 I-site; other site 910348004677 putative transporter; Provisional; Region: PRK10054 910348004678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348004679 putative substrate translocation pore; other site 910348004680 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 910348004681 EamA-like transporter family; Region: EamA; pfam00892 910348004682 EamA-like transporter family; Region: EamA; pfam00892 910348004683 hypothetical protein; Provisional; Region: PRK10106 910348004684 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 910348004685 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348004686 MarR family; Region: MarR_2; cl17246 910348004687 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 910348004688 inner membrane protein; Provisional; Region: PRK10995 910348004689 putative arabinose transporter; Provisional; Region: PRK03545 910348004690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348004691 putative substrate translocation pore; other site 910348004692 Transcriptional regulator [Transcription]; Region: LysR; COG0583 910348004693 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348004694 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 910348004695 putative dimerization interface [polypeptide binding]; other site 910348004696 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 910348004697 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 910348004698 NAD(P) binding site [chemical binding]; other site 910348004699 catalytic residues [active] 910348004700 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 910348004701 glutaminase; Provisional; Region: PRK00971 910348004702 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 910348004703 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 910348004704 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 910348004705 metal binding site [ion binding]; metal-binding site 910348004706 active site 910348004707 I-site; other site 910348004708 altronate oxidoreductase; Provisional; Region: PRK03643 910348004709 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 910348004710 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 910348004711 Predicted membrane protein [Function unknown]; Region: COG3781 910348004712 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 910348004713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348004714 S-adenosylmethionine binding site [chemical binding]; other site 910348004715 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 910348004716 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 910348004717 putative active site; other site 910348004718 catalytic residue [active] 910348004719 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 910348004720 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 910348004721 ligand binding site [chemical binding]; other site 910348004722 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 910348004723 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 910348004724 TM-ABC transporter signature motif; other site 910348004725 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 910348004726 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 910348004727 TM-ABC transporter signature motif; other site 910348004728 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 910348004729 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 910348004730 Walker A/P-loop; other site 910348004731 ATP binding site [chemical binding]; other site 910348004732 Q-loop/lid; other site 910348004733 ABC transporter signature motif; other site 910348004734 Walker B; other site 910348004735 D-loop; other site 910348004736 H-loop/switch region; other site 910348004737 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 910348004738 transcriptional regulator LsrR; Provisional; Region: PRK15418 910348004739 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 910348004740 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 910348004741 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 910348004742 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 910348004743 putative N- and C-terminal domain interface [polypeptide binding]; other site 910348004744 putative active site [active] 910348004745 putative MgATP binding site [chemical binding]; other site 910348004746 catalytic site [active] 910348004747 metal binding site [ion binding]; metal-binding site 910348004748 putative carbohydrate binding site [chemical binding]; other site 910348004749 putative lipoprotein/autotransporter domain-containing protein; Provisional; Region: PRK14849 910348004750 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 910348004751 HTH-like domain; Region: HTH_21; pfam13276 910348004752 Integrase core domain; Region: rve; pfam00665 910348004753 Integrase core domain; Region: rve_3; pfam13683 910348004754 IS2 repressor TnpA; Reviewed; Region: PRK09413 910348004755 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 910348004756 putative lipoprotein; Provisional; Region: PRK09707 910348004757 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 910348004758 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 910348004759 Autotransporter beta-domain; Region: Autotransporter; pfam03797 910348004760 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 910348004761 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 910348004762 non-specific DNA binding site [nucleotide binding]; other site 910348004763 salt bridge; other site 910348004764 sequence-specific DNA binding site [nucleotide binding]; other site 910348004765 HipA N-terminal domain; Region: Couple_hipA; pfam13657 910348004766 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 910348004767 HipA-like N-terminal domain; Region: HipA_N; pfam07805 910348004768 HipA-like C-terminal domain; Region: HipA_C; pfam07804 910348004769 Integrase core domain; Region: rve_3; cl15866 910348004770 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 910348004771 active site 910348004772 catalytic residues [active] 910348004773 Int/Topo IB signature motif; other site 910348004774 DNA binding site [nucleotide binding] 910348004775 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 910348004776 active site 910348004777 catalytic residues [active] 910348004778 DNA binding site [nucleotide binding] 910348004779 Int/Topo IB signature motif; other site 910348004780 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 910348004781 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 910348004782 salt bridge; other site 910348004783 non-specific DNA binding site [nucleotide binding]; other site 910348004784 sequence-specific DNA binding site [nucleotide binding]; other site 910348004785 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 910348004786 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 910348004787 active site 910348004788 catalytic site [active] 910348004789 substrate binding site [chemical binding]; other site 910348004790 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 910348004791 ThiF family; Region: ThiF; pfam00899 910348004792 ATP binding site [chemical binding]; other site 910348004793 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 910348004794 Restriction endonuclease; Region: Mrr_cat; pfam04471 910348004795 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 910348004796 C factor cell-cell signaling protein; Provisional; Region: PRK09009 910348004797 NAD(P) binding site [chemical binding]; other site 910348004798 active site 910348004799 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 910348004800 Transposase; Region: HTH_Tnp_1; pfam01527 910348004801 DNA-binding interface [nucleotide binding]; DNA binding site 910348004802 Helix-turn-helix domain; Region: HTH_38; pfam13936 910348004803 Winged helix-turn helix; Region: HTH_29; pfam13551 910348004804 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 910348004805 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 910348004806 putative active site [active] 910348004807 putative NTP binding site [chemical binding]; other site 910348004808 putative nucleic acid binding site [nucleotide binding]; other site 910348004809 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 910348004810 Transposase; Region: DEDD_Tnp_IS110; pfam01548 910348004811 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 910348004812 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 910348004813 Integrase core domain; Region: rve_3; pfam13683 910348004814 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 910348004815 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 910348004816 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 910348004817 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 910348004818 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 910348004819 Transposase; Region: HTH_Tnp_1; pfam01527 910348004820 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 910348004821 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 910348004822 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 910348004823 homodimer interface [polypeptide binding]; other site 910348004824 putative GKAP docking site [polypeptide binding]; other site 910348004825 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 910348004826 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 910348004827 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 910348004828 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 910348004829 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 910348004830 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 910348004831 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 910348004832 SecY translocase; Region: SecY; pfam00344 910348004833 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 910348004834 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 910348004835 Cl binding site [ion binding]; other site 910348004836 oligomer interface [polypeptide binding]; other site 910348004837 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 910348004838 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 910348004839 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 910348004840 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 910348004841 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 910348004842 Restriction endonuclease; Region: Mrr_cat; pfam04471 910348004843 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 910348004844 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 910348004845 ATP binding site [chemical binding]; other site 910348004846 putative Mg++ binding site [ion binding]; other site 910348004847 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 910348004848 nucleotide binding region [chemical binding]; other site 910348004849 ATP-binding site [chemical binding]; other site 910348004850 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 910348004851 active site 910348004852 catalytic residues [active] 910348004853 Int/Topo IB signature motif; other site 910348004854 DNA binding site [nucleotide binding] 910348004855 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 910348004856 active site 910348004857 catalytic residues [active] 910348004858 DNA binding site [nucleotide binding] 910348004859 Int/Topo IB signature motif; other site 910348004860 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348004861 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 910348004862 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 910348004863 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 910348004864 PapC C-terminal domain; Region: PapC_C; pfam13953 910348004865 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 910348004866 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 910348004867 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 910348004868 mannosyl binding site [chemical binding]; other site 910348004869 Fimbrial protein; Region: Fimbrial; pfam00419 910348004870 putative oxidoreductase; Provisional; Region: PRK09939 910348004871 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 910348004872 putative molybdopterin cofactor binding site [chemical binding]; other site 910348004873 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 910348004874 putative molybdopterin cofactor binding site; other site 910348004875 transcriptional regulator YdeO; Provisional; Region: PRK09940 910348004876 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348004877 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 910348004878 Sulfatase; Region: Sulfatase; pfam00884 910348004879 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 910348004880 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 910348004881 FeS/SAM binding site; other site 910348004882 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 910348004883 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 910348004884 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 910348004885 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 910348004886 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 910348004887 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 910348004888 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 910348004889 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 910348004890 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 910348004891 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 910348004892 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 910348004893 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 910348004894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348004895 catalytic residue [active] 910348004896 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 910348004897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 910348004898 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 910348004899 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 910348004900 heme-binding site [chemical binding]; other site 910348004901 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 910348004902 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 910348004903 metal binding site [ion binding]; metal-binding site 910348004904 active site 910348004905 I-site; other site 910348004906 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 910348004907 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 910348004908 putative active site [active] 910348004909 heme pocket [chemical binding]; other site 910348004910 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 910348004911 putative active site [active] 910348004912 heme pocket [chemical binding]; other site 910348004913 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 910348004914 metal binding site [ion binding]; metal-binding site 910348004915 active site 910348004916 I-site; other site 910348004917 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 910348004918 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 910348004919 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 910348004920 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 910348004921 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 910348004922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348004923 dimer interface [polypeptide binding]; other site 910348004924 conserved gate region; other site 910348004925 putative PBP binding loops; other site 910348004926 ABC-ATPase subunit interface; other site 910348004927 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 910348004928 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 910348004929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348004930 dimer interface [polypeptide binding]; other site 910348004931 conserved gate region; other site 910348004932 putative PBP binding loops; other site 910348004933 ABC-ATPase subunit interface; other site 910348004934 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 910348004935 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 910348004936 Walker A/P-loop; other site 910348004937 ATP binding site [chemical binding]; other site 910348004938 Q-loop/lid; other site 910348004939 ABC transporter signature motif; other site 910348004940 Walker B; other site 910348004941 D-loop; other site 910348004942 H-loop/switch region; other site 910348004943 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 910348004944 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 910348004945 ABC transporter; Region: ABC_tran; pfam00005 910348004946 Q-loop/lid; other site 910348004947 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 910348004948 ABC transporter signature motif; other site 910348004949 Walker B; other site 910348004950 D-loop; other site 910348004951 H-loop/switch region; other site 910348004952 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 910348004953 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 910348004954 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 910348004955 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 910348004956 malate dehydrogenase; Provisional; Region: PRK13529 910348004957 Malic enzyme, N-terminal domain; Region: malic; pfam00390 910348004958 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 910348004959 NAD(P) binding site [chemical binding]; other site 910348004960 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 910348004961 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 910348004962 NAD binding site [chemical binding]; other site 910348004963 substrate binding site [chemical binding]; other site 910348004964 catalytic Zn binding site [ion binding]; other site 910348004965 tetramer interface [polypeptide binding]; other site 910348004966 structural Zn binding site [ion binding]; other site 910348004967 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 910348004968 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 910348004969 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 910348004970 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 910348004971 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 910348004972 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 910348004973 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 910348004974 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 910348004975 molybdopterin cofactor binding site; other site 910348004976 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 910348004977 aromatic amino acid exporter; Provisional; Region: PRK11689 910348004978 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 910348004979 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 910348004980 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 910348004981 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 910348004982 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 910348004983 [4Fe-4S] binding site [ion binding]; other site 910348004984 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 910348004985 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 910348004986 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 910348004987 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 910348004988 molybdopterin cofactor binding site; other site 910348004989 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 910348004990 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 910348004991 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 910348004992 hypothetical protein; Provisional; Region: PRK10281 910348004993 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 910348004994 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 910348004995 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 910348004996 active site 1 [active] 910348004997 dimer interface [polypeptide binding]; other site 910348004998 hexamer interface [polypeptide binding]; other site 910348004999 active site 2 [active] 910348005000 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 910348005001 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 910348005002 Transposase [DNA replication, recombination, and repair]; Region: COG5433 910348005003 Transposase [DNA replication, recombination, and repair]; Region: COG5433 910348005004 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 910348005005 RHS Repeat; Region: RHS_repeat; pfam05593 910348005006 RHS Repeat; Region: RHS_repeat; pfam05593 910348005007 RHS protein; Region: RHS; pfam03527 910348005008 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 910348005009 RHS Repeat; Region: RHS_repeat; pfam05593 910348005010 RHS Repeat; Region: RHS_repeat; pfam05593 910348005011 RHS Repeat; Region: RHS_repeat; pfam05593 910348005012 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 910348005013 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 910348005014 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 910348005015 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 910348005016 L-asparagine permease; Provisional; Region: PRK15049 910348005017 PQQ-like domain; Region: PQQ_2; pfam13360 910348005018 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 910348005019 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 910348005020 N-terminal plug; other site 910348005021 ligand-binding site [chemical binding]; other site 910348005022 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 910348005023 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 910348005024 DNA-binding site [nucleotide binding]; DNA binding site 910348005025 FCD domain; Region: FCD; pfam07729 910348005026 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 910348005027 Prostaglandin dehydrogenases; Region: PGDH; cd05288 910348005028 dimer interface [polypeptide binding]; other site 910348005029 NAD(P) binding site [chemical binding]; other site 910348005030 substrate binding site [chemical binding]; other site 910348005031 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 910348005032 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 910348005033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 910348005034 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 910348005035 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 910348005036 tetrameric interface [polypeptide binding]; other site 910348005037 NAD binding site [chemical binding]; other site 910348005038 catalytic residues [active] 910348005039 substrate binding site [chemical binding]; other site 910348005040 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 910348005041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348005042 ABC-ATPase subunit interface; other site 910348005043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348005044 dimer interface [polypeptide binding]; other site 910348005045 conserved gate region; other site 910348005046 putative PBP binding loops; other site 910348005047 ABC-ATPase subunit interface; other site 910348005048 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 910348005049 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 910348005050 Walker A/P-loop; other site 910348005051 ATP binding site [chemical binding]; other site 910348005052 Q-loop/lid; other site 910348005053 ABC transporter signature motif; other site 910348005054 Walker B; other site 910348005055 D-loop; other site 910348005056 H-loop/switch region; other site 910348005057 TOBE domain; Region: TOBE_2; pfam08402 910348005058 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 910348005059 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 910348005060 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 910348005061 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 910348005062 DNA-binding site [nucleotide binding]; DNA binding site 910348005063 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 910348005064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348005065 homodimer interface [polypeptide binding]; other site 910348005066 catalytic residue [active] 910348005067 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 910348005068 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 910348005069 sequence-specific DNA binding site [nucleotide binding]; other site 910348005070 salt bridge; other site 910348005071 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 910348005072 Peptidase family U32; Region: Peptidase_U32; pfam01136 910348005073 Collagenase; Region: DUF3656; pfam12392 910348005074 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 910348005075 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 910348005076 non-specific DNA binding site [nucleotide binding]; other site 910348005077 salt bridge; other site 910348005078 sequence-specific DNA binding site [nucleotide binding]; other site 910348005079 Cupin domain; Region: Cupin_2; pfam07883 910348005080 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 910348005081 benzoate transporter; Region: benE; TIGR00843 910348005082 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 910348005083 Probable transposase; Region: OrfB_IS605; pfam01385 910348005084 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 910348005085 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 910348005086 Transposase IS200 like; Region: Y1_Tnp; pfam01797 910348005087 Transposase IS200 like; Region: Y1_Tnp; cl00848 910348005088 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 910348005089 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 910348005090 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 910348005091 gating phenylalanine in ion channel; other site 910348005092 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 910348005093 putative trimer interface [polypeptide binding]; other site 910348005094 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 910348005095 putative CoA binding site [chemical binding]; other site 910348005096 putative trimer interface [polypeptide binding]; other site 910348005097 putative CoA binding site [chemical binding]; other site 910348005098 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 910348005099 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 910348005100 Coenzyme A binding pocket [chemical binding]; other site 910348005101 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 910348005102 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 910348005103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 910348005104 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 910348005105 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 910348005106 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348005107 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 910348005108 dimerization interface [polypeptide binding]; other site 910348005109 cytochrome b561; Provisional; Region: PRK11513 910348005110 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl17742 910348005111 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 910348005112 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 910348005113 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 910348005114 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 910348005115 NAD binding site [chemical binding]; other site 910348005116 catalytic residues [active] 910348005117 substrate binding site [chemical binding]; other site 910348005118 azoreductase; Reviewed; Region: PRK00170 910348005119 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 910348005120 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 910348005121 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 910348005122 active site 910348005123 Dual specificity phosphatase, catalytic domain; Region: DSPc; smart00195 910348005124 active site 910348005125 catalytic residues [active] 910348005126 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 910348005127 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 910348005128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348005129 S-adenosylmethionine binding site [chemical binding]; other site 910348005130 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 910348005131 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 910348005132 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 910348005133 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 910348005134 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 910348005135 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 910348005136 active site 910348005137 catalytic tetrad [active] 910348005138 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 910348005139 homodimer interface [polypeptide binding]; other site 910348005140 putative GKAP docking site [polypeptide binding]; other site 910348005141 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 910348005142 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 910348005143 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 910348005144 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 910348005145 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 910348005146 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 910348005147 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 910348005148 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 910348005149 Transposase; Region: HTH_Tnp_1; pfam01527 910348005150 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 910348005151 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 910348005152 putative trimer interface [polypeptide binding]; other site 910348005153 putative metal binding site [ion binding]; other site 910348005154 PaaX-like protein; Region: PaaX; pfam07848 910348005155 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 910348005156 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 910348005157 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 910348005158 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 910348005159 active site 910348005160 AMP binding site [chemical binding]; other site 910348005161 homodimer interface [polypeptide binding]; other site 910348005162 acyl-activating enzyme (AAE) consensus motif; other site 910348005163 CoA binding site [chemical binding]; other site 910348005164 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 910348005165 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 910348005166 dimer interface [polypeptide binding]; other site 910348005167 active site 910348005168 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 910348005169 CoenzymeA binding site [chemical binding]; other site 910348005170 subunit interaction site [polypeptide binding]; other site 910348005171 PHB binding site; other site 910348005172 3-hydroxyacyl-CoA dehydrogenase PaaC; Region: PaaC-3OHAcCoADH; TIGR02279 910348005173 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 910348005174 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 910348005175 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 910348005176 enoyl-CoA hydratase; Provisional; Region: PRK08140 910348005177 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 910348005178 substrate binding site [chemical binding]; other site 910348005179 oxyanion hole (OAH) forming residues; other site 910348005180 trimer interface [polypeptide binding]; other site 910348005181 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 910348005182 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 910348005183 substrate binding site [chemical binding]; other site 910348005184 oxyanion hole (OAH) forming residues; other site 910348005185 trimer interface [polypeptide binding]; other site 910348005186 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 910348005187 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 910348005188 FAD binding pocket [chemical binding]; other site 910348005189 FAD binding motif [chemical binding]; other site 910348005190 phosphate binding motif [ion binding]; other site 910348005191 beta-alpha-beta structure motif; other site 910348005192 NAD(p) ribose binding residues [chemical binding]; other site 910348005193 NAD binding pocket [chemical binding]; other site 910348005194 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 910348005195 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 910348005196 catalytic loop [active] 910348005197 iron binding site [ion binding]; other site 910348005198 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 910348005199 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 910348005200 phenylacetate-CoA oxygenase, PaaI subunit; Region: PA_CoA_Oxy3; TIGR02158 910348005201 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 910348005202 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 910348005203 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 910348005204 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 910348005205 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 910348005206 substrate binding site [chemical binding]; other site 910348005207 dimer interface [polypeptide binding]; other site 910348005208 NADP binding site [chemical binding]; other site 910348005209 catalytic residues [active] 910348005210 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 910348005211 substrate binding site [chemical binding]; other site 910348005212 tyramine oxidase; Provisional; Region: tynA; PRK14696 910348005213 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 910348005214 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 910348005215 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 910348005216 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 910348005217 Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113 910348005218 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 910348005219 NAD(P) binding site [chemical binding]; other site 910348005220 catalytic residues [active] 910348005221 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 910348005222 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348005223 hypothetical protein; Provisional; Region: PRK10695 910348005224 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 910348005225 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 910348005226 putative ligand binding site [chemical binding]; other site 910348005227 putative NAD binding site [chemical binding]; other site 910348005228 catalytic site [active] 910348005229 heat-inducible protein; Provisional; Region: PRK10449 910348005230 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 910348005231 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 910348005232 dimer interface [polypeptide binding]; other site 910348005233 PYR/PP interface [polypeptide binding]; other site 910348005234 TPP binding site [chemical binding]; other site 910348005235 substrate binding site [chemical binding]; other site 910348005236 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 910348005237 Domain of unknown function; Region: EKR; smart00890 910348005238 4Fe-4S binding domain; Region: Fer4; pfam00037 910348005239 4Fe-4S binding domain; Region: Fer4; pfam00037 910348005240 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 910348005241 TPP-binding site [chemical binding]; other site 910348005242 dimer interface [polypeptide binding]; other site 910348005243 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 910348005244 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 910348005245 trimer interface [polypeptide binding]; other site 910348005246 eyelet of channel; other site 910348005247 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 910348005248 Ligand Binding Site [chemical binding]; other site 910348005249 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 910348005250 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 910348005251 Ligand Binding Site [chemical binding]; other site 910348005252 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 910348005253 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 910348005254 ATP binding site [chemical binding]; other site 910348005255 Mg++ binding site [ion binding]; other site 910348005256 motif III; other site 910348005257 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 910348005258 nucleotide binding region [chemical binding]; other site 910348005259 ATP-binding site [chemical binding]; other site 910348005260 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 910348005261 putative RNA binding site [nucleotide binding]; other site 910348005262 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 910348005263 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 910348005264 Cl binding site [ion binding]; other site 910348005265 oligomer interface [polypeptide binding]; other site 910348005266 PAS domain; Region: PAS; smart00091 910348005267 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 910348005268 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 910348005269 metal binding site [ion binding]; metal-binding site 910348005270 active site 910348005271 I-site; other site 910348005272 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 910348005273 Smr domain; Region: Smr; pfam01713 910348005274 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 910348005275 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348005276 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 910348005277 putative substrate binding pocket [chemical binding]; other site 910348005278 putative dimerization interface [polypeptide binding]; other site 910348005279 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 910348005280 amidohydrolase; Region: amidohydrolases; TIGR01891 910348005281 putative metal binding site [ion binding]; other site 910348005282 dimer interface [polypeptide binding]; other site 910348005283 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 910348005284 amidohydrolase; Region: amidohydrolases; TIGR01891 910348005285 putative metal binding site [ion binding]; other site 910348005286 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 910348005287 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 910348005288 DNA binding site [nucleotide binding] 910348005289 active site 910348005290 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 910348005291 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 910348005292 ligand binding site [chemical binding]; other site 910348005293 flexible hinge region; other site 910348005294 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 910348005295 putative switch regulator; other site 910348005296 non-specific DNA interactions [nucleotide binding]; other site 910348005297 DNA binding site [nucleotide binding] 910348005298 sequence specific DNA binding site [nucleotide binding]; other site 910348005299 putative cAMP binding site [chemical binding]; other site 910348005300 universal stress protein UspE; Provisional; Region: PRK11175 910348005301 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 910348005302 Ligand Binding Site [chemical binding]; other site 910348005303 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 910348005304 Ligand Binding Site [chemical binding]; other site 910348005305 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 910348005306 Mechanosensitive ion channel; Region: MS_channel; pfam00924 910348005307 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 910348005308 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 910348005309 peptide binding site [polypeptide binding]; other site 910348005310 Transcriptional regulator [Transcription]; Region: LysR; COG0583 910348005311 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348005312 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 910348005313 putative effector binding pocket; other site 910348005314 putative dimerization interface [polypeptide binding]; other site 910348005315 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 910348005316 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 910348005317 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 910348005318 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 910348005319 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 910348005320 putative active site [active] 910348005321 Zn binding site [ion binding]; other site 910348005322 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 910348005323 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 910348005324 active site 910348005325 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 910348005326 dimer interface [polypeptide binding]; other site 910348005327 catalytic triad [active] 910348005328 peroxidatic and resolving cysteines [active] 910348005329 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 910348005330 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 910348005331 putative aromatic amino acid binding site; other site 910348005332 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348005333 Walker A motif; other site 910348005334 ATP binding site [chemical binding]; other site 910348005335 Walker B motif; other site 910348005336 arginine finger; other site 910348005337 hypothetical protein; Provisional; Region: PRK05415 910348005338 TIGR01620 family protein; Region: hyp_HI0043 910348005339 Predicted ATPase [General function prediction only]; Region: COG3106 910348005340 Transcriptional regulators [Transcription]; Region: PurR; COG1609 910348005341 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 910348005342 DNA binding site [nucleotide binding] 910348005343 domain linker motif; other site 910348005344 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 910348005345 putative dimerization interface [polypeptide binding]; other site 910348005346 putative ligand binding site [chemical binding]; other site 910348005347 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 910348005348 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 910348005349 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 910348005350 Walker A/P-loop; other site 910348005351 ATP binding site [chemical binding]; other site 910348005352 Q-loop/lid; other site 910348005353 ABC transporter signature motif; other site 910348005354 Walker B; other site 910348005355 D-loop; other site 910348005356 H-loop/switch region; other site 910348005357 TOBE domain; Region: TOBE_2; pfam08402 910348005358 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 910348005359 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 910348005360 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 910348005361 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 910348005362 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 910348005363 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 910348005364 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 910348005365 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 910348005366 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 910348005367 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 910348005368 putative NAD(P) binding site [chemical binding]; other site 910348005369 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 910348005370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348005371 dimer interface [polypeptide binding]; other site 910348005372 conserved gate region; other site 910348005373 putative PBP binding loops; other site 910348005374 ABC-ATPase subunit interface; other site 910348005375 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 910348005376 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348005377 dimer interface [polypeptide binding]; other site 910348005378 conserved gate region; other site 910348005379 putative PBP binding loops; other site 910348005380 ABC-ATPase subunit interface; other site 910348005381 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 910348005382 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 910348005383 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 910348005384 sucrose phosphorylase; Provisional; Region: PRK13840 910348005385 active site 910348005386 homodimer interface [polypeptide binding]; other site 910348005387 catalytic site [active] 910348005388 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 910348005389 active site residue [active] 910348005390 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 910348005391 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 910348005392 phage shock protein C; Region: phageshock_pspC; TIGR02978 910348005393 phage shock protein B; Provisional; Region: pspB; PRK09458 910348005394 phage shock protein PspA; Provisional; Region: PRK10698 910348005395 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 910348005396 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348005397 Walker A motif; other site 910348005398 ATP binding site [chemical binding]; other site 910348005399 Walker B motif; other site 910348005400 arginine finger; other site 910348005401 4-aminobutyrate transaminase; Provisional; Region: PRK09792 910348005402 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 910348005403 inhibitor-cofactor binding pocket; inhibition site 910348005404 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348005405 catalytic residue [active] 910348005406 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 910348005407 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 910348005408 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 910348005409 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 910348005410 NAD(P) binding site [chemical binding]; other site 910348005411 catalytic residues [active] 910348005412 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 910348005413 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 910348005414 non-specific DNA binding site [nucleotide binding]; other site 910348005415 salt bridge; other site 910348005416 sequence-specific DNA binding site [nucleotide binding]; other site 910348005417 Cupin domain; Region: Cupin_2; pfam07883 910348005418 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 910348005419 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 910348005420 catalytic triad [active] 910348005421 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 910348005422 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 910348005423 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 910348005424 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 910348005425 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 910348005426 peptide binding site [polypeptide binding]; other site 910348005427 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 910348005428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348005429 dimer interface [polypeptide binding]; other site 910348005430 conserved gate region; other site 910348005431 putative PBP binding loops; other site 910348005432 ABC-ATPase subunit interface; other site 910348005433 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 910348005434 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 910348005435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348005436 dimer interface [polypeptide binding]; other site 910348005437 conserved gate region; other site 910348005438 putative PBP binding loops; other site 910348005439 ABC-ATPase subunit interface; other site 910348005440 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 910348005441 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 910348005442 Walker A/P-loop; other site 910348005443 ATP binding site [chemical binding]; other site 910348005444 Q-loop/lid; other site 910348005445 ABC transporter signature motif; other site 910348005446 Walker B; other site 910348005447 D-loop; other site 910348005448 H-loop/switch region; other site 910348005449 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 910348005450 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 910348005451 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 910348005452 Walker A/P-loop; other site 910348005453 ATP binding site [chemical binding]; other site 910348005454 Q-loop/lid; other site 910348005455 ABC transporter signature motif; other site 910348005456 Walker B; other site 910348005457 D-loop; other site 910348005458 H-loop/switch region; other site 910348005459 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 910348005460 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 910348005461 NAD binding site [chemical binding]; other site 910348005462 homotetramer interface [polypeptide binding]; other site 910348005463 homodimer interface [polypeptide binding]; other site 910348005464 substrate binding site [chemical binding]; other site 910348005465 active site 910348005466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 910348005467 Uncharacterized conserved protein [Function unknown]; Region: COG2128 910348005468 exoribonuclease II; Provisional; Region: PRK05054 910348005469 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 910348005470 RNB domain; Region: RNB; pfam00773 910348005471 S1 RNA binding domain; Region: S1; pfam00575 910348005472 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 910348005473 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 910348005474 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 910348005475 translation initiation factor Sui1; Validated; Region: PRK06824 910348005476 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 910348005477 putative rRNA binding site [nucleotide binding]; other site 910348005478 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 910348005479 active site 910348005480 dimer interface [polypeptide binding]; other site 910348005481 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 910348005482 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 910348005483 TPR motif; other site 910348005484 binding surface 910348005485 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 910348005486 binding surface 910348005487 TPR motif; other site 910348005488 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 910348005489 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 910348005490 active site 910348005491 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 910348005492 dimerization interface [polypeptide binding]; other site 910348005493 active site 910348005494 aconitate hydratase; Validated; Region: PRK09277 910348005495 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 910348005496 substrate binding site [chemical binding]; other site 910348005497 ligand binding site [chemical binding]; other site 910348005498 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 910348005499 substrate binding site [chemical binding]; other site 910348005500 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 910348005501 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348005502 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 910348005503 substrate binding site [chemical binding]; other site 910348005504 putative dimerization interface [polypeptide binding]; other site 910348005505 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 910348005506 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 910348005507 active site 910348005508 interdomain interaction site; other site 910348005509 putative metal-binding site [ion binding]; other site 910348005510 nucleotide binding site [chemical binding]; other site 910348005511 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 910348005512 domain I; other site 910348005513 DNA binding groove [nucleotide binding] 910348005514 phosphate binding site [ion binding]; other site 910348005515 domain II; other site 910348005516 domain III; other site 910348005517 nucleotide binding site [chemical binding]; other site 910348005518 catalytic site [active] 910348005519 domain IV; other site 910348005520 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 910348005521 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 910348005522 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 910348005523 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 910348005524 hypothetical protein; Provisional; Region: PRK11037 910348005525 putative inner membrane peptidase; Provisional; Region: PRK11778 910348005526 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 910348005527 tandem repeat interface [polypeptide binding]; other site 910348005528 oligomer interface [polypeptide binding]; other site 910348005529 active site residues [active] 910348005530 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 910348005531 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 910348005532 NADP binding site [chemical binding]; other site 910348005533 homodimer interface [polypeptide binding]; other site 910348005534 active site 910348005535 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 910348005536 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 910348005537 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 910348005538 homodimer interface [polypeptide binding]; other site 910348005539 Walker A motif; other site 910348005540 ATP binding site [chemical binding]; other site 910348005541 hydroxycobalamin binding site [chemical binding]; other site 910348005542 Walker B motif; other site 910348005543 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 910348005544 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 910348005545 RNA binding surface [nucleotide binding]; other site 910348005546 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 910348005547 probable active site [active] 910348005548 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 910348005549 hypothetical protein; Provisional; Region: PRK11630 910348005550 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 910348005551 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 910348005552 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 910348005553 anthranilate synthase component I; Provisional; Region: PRK13564 910348005554 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 910348005555 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 910348005556 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 910348005557 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 910348005558 glutamine binding [chemical binding]; other site 910348005559 catalytic triad [active] 910348005560 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 910348005561 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 910348005562 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 910348005563 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 910348005564 active site 910348005565 ribulose/triose binding site [chemical binding]; other site 910348005566 phosphate binding site [ion binding]; other site 910348005567 substrate (anthranilate) binding pocket [chemical binding]; other site 910348005568 product (indole) binding pocket [chemical binding]; other site 910348005569 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 910348005570 active site 910348005571 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 910348005572 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 910348005573 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348005574 catalytic residue [active] 910348005575 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 910348005576 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 910348005577 substrate binding site [chemical binding]; other site 910348005578 active site 910348005579 catalytic residues [active] 910348005580 heterodimer interface [polypeptide binding]; other site 910348005581 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 910348005582 dimerization interface [polypeptide binding]; other site 910348005583 metal binding site [ion binding]; metal-binding site 910348005584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 910348005585 outer membrane protein W; Provisional; Region: PRK10959 910348005586 hypothetical protein; Provisional; Region: PRK02868 910348005587 intracellular septation protein A; Reviewed; Region: PRK00259 910348005588 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 910348005589 transport protein TonB; Provisional; Region: PRK10819 910348005590 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 910348005591 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 910348005592 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 910348005593 catalytic residues [active] 910348005594 catalytic nucleophile [active] 910348005595 Presynaptic Site I dimer interface [polypeptide binding]; other site 910348005596 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 910348005597 Synaptic Flat tetramer interface [polypeptide binding]; other site 910348005598 Synaptic Site I dimer interface [polypeptide binding]; other site 910348005599 DNA binding site [nucleotide binding] 910348005600 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 910348005601 DNA-binding interface [nucleotide binding]; DNA binding site 910348005602 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 910348005603 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 910348005604 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 910348005605 Baseplate J-like protein; Region: Baseplate_J; cl01294 910348005606 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 910348005607 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 910348005608 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 910348005609 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 910348005610 N-acetyl-D-glucosamine binding site [chemical binding]; other site 910348005611 catalytic residue [active] 910348005612 Protein of unknown function (DUF3277); Region: DUF3277; pfam11681 910348005613 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 910348005614 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 910348005615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 910348005616 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 910348005617 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 910348005618 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 910348005619 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 910348005620 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 910348005621 Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045 910348005622 KilA-N domain; Region: KilA-N; pfam04383 910348005623 ORF11CD3 domain; Region: ORF11CD3; pfam10549 910348005624 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 910348005625 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 910348005626 catalytic residues [active] 910348005627 phage holin, lambda family; Region: holin_lambda; TIGR01594 910348005628 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 910348005629 NinB protein; Region: NinB; pfam05772 910348005630 Protein of unknown function (DUF550); Region: DUF550; pfam04447 910348005631 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 910348005632 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 910348005633 phage replicative helicase, DnaB family, HK022 subfamily; Region: phage_DnaB; TIGR03600 910348005634 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 910348005635 Walker A motif; other site 910348005636 ATP binding site [chemical binding]; other site 910348005637 Walker B motif; other site 910348005638 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 910348005639 Bacteriophage CII protein; Region: Phage_CII; pfam05269 910348005640 Predicted transcriptional regulator [Transcription]; Region: COG2932 910348005641 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 910348005642 Catalytic site [active] 910348005643 exodeoxyribonuclease X; Provisional; Region: PRK07983 910348005644 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 910348005645 active site 910348005646 catalytic site [active] 910348005647 substrate binding site [chemical binding]; other site 910348005648 AAA domain; Region: AAA_22; pfam13401 910348005649 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 910348005650 Protein of unknown function (DUF1317); Region: DUF1317; pfam07026 910348005651 integrase; Provisional; Region: PRK09692 910348005652 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 910348005653 active site 910348005654 Int/Topo IB signature motif; other site 910348005655 voltage-gated potassium channel; Provisional; Region: PRK10537 910348005656 Ion channel; Region: Ion_trans_2; pfam07885 910348005657 TrkA-N domain; Region: TrkA_N; pfam02254 910348005658 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 910348005659 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 910348005660 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 910348005661 putative active site [active] 910348005662 catalytic site [active] 910348005663 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 910348005664 putative active site [active] 910348005665 catalytic site [active] 910348005666 dsDNA-mimic protein; Reviewed; Region: PRK05094 910348005667 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 910348005668 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 910348005669 Walker A/P-loop; other site 910348005670 ATP binding site [chemical binding]; other site 910348005671 Q-loop/lid; other site 910348005672 ABC transporter signature motif; other site 910348005673 Walker B; other site 910348005674 D-loop; other site 910348005675 H-loop/switch region; other site 910348005676 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 910348005677 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 910348005678 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 910348005679 Walker A/P-loop; other site 910348005680 ATP binding site [chemical binding]; other site 910348005681 Q-loop/lid; other site 910348005682 ABC transporter signature motif; other site 910348005683 Walker B; other site 910348005684 D-loop; other site 910348005685 H-loop/switch region; other site 910348005686 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 910348005687 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 910348005688 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 910348005689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348005690 dimer interface [polypeptide binding]; other site 910348005691 conserved gate region; other site 910348005692 putative PBP binding loops; other site 910348005693 ABC-ATPase subunit interface; other site 910348005694 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 910348005695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348005696 dimer interface [polypeptide binding]; other site 910348005697 conserved gate region; other site 910348005698 putative PBP binding loops; other site 910348005699 ABC-ATPase subunit interface; other site 910348005700 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 910348005701 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 910348005702 peptide binding site [polypeptide binding]; other site 910348005703 hypothetical protein; Provisional; Region: PRK11111 910348005704 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 910348005705 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 910348005706 putative catalytic cysteine [active] 910348005707 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 910348005708 putative active site [active] 910348005709 metal binding site [ion binding]; metal-binding site 910348005710 thymidine kinase; Provisional; Region: PRK04296 910348005711 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 910348005712 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 910348005713 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 910348005714 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 910348005715 active site 910348005716 tetramer interface; other site 910348005717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348005718 active site 910348005719 response regulator of RpoS; Provisional; Region: PRK10693 910348005720 phosphorylation site [posttranslational modification] 910348005721 intermolecular recognition site; other site 910348005722 dimerization interface [polypeptide binding]; other site 910348005723 hypothetical protein; Provisional; Region: PRK10279 910348005724 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 910348005725 active site 910348005726 nucleophile elbow; other site 910348005727 hypothetical protein; Provisional; Region: PRK01617 910348005728 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 910348005729 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 910348005730 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 910348005731 putative active site [active] 910348005732 putative substrate binding site [chemical binding]; other site 910348005733 putative cosubstrate binding site; other site 910348005734 catalytic site [active] 910348005735 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 910348005736 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 910348005737 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 910348005738 4Fe-4S binding domain; Region: Fer4; cl02805 910348005739 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 910348005740 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 910348005741 [4Fe-4S] binding site [ion binding]; other site 910348005742 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 910348005743 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 910348005744 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 910348005745 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 910348005746 molybdopterin cofactor binding site; other site 910348005747 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 910348005748 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 910348005749 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 910348005750 dimerization interface [polypeptide binding]; other site 910348005751 Histidine kinase; Region: HisKA_3; pfam07730 910348005752 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348005753 ATP binding site [chemical binding]; other site 910348005754 Mg2+ binding site [ion binding]; other site 910348005755 G-X-G motif; other site 910348005756 transcriptional regulator NarL; Provisional; Region: PRK10651 910348005757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348005758 active site 910348005759 phosphorylation site [posttranslational modification] 910348005760 intermolecular recognition site; other site 910348005761 dimerization interface [polypeptide binding]; other site 910348005762 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 910348005763 DNA binding residues [nucleotide binding] 910348005764 dimerization interface [polypeptide binding]; other site 910348005765 putative invasin; Provisional; Region: PRK10177 910348005766 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 910348005767 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 910348005768 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 910348005769 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 910348005770 putative active site pocket [active] 910348005771 dimerization interface [polypeptide binding]; other site 910348005772 putative catalytic residue [active] 910348005773 cation transport regulator; Reviewed; Region: chaB; PRK09582 910348005774 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 910348005775 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 910348005776 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 910348005777 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 910348005778 hypothetical protein; Provisional; Region: PRK10941 910348005779 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 910348005780 hypothetical protein; Provisional; Region: PRK10278 910348005781 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 910348005782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348005783 peptide chain release factor 1; Validated; Region: prfA; PRK00591 910348005784 This domain is found in peptide chain release factors; Region: PCRF; smart00937 910348005785 RF-1 domain; Region: RF-1; pfam00472 910348005786 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 910348005787 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 910348005788 tRNA; other site 910348005789 putative tRNA binding site [nucleotide binding]; other site 910348005790 putative NADP binding site [chemical binding]; other site 910348005791 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 910348005792 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 910348005793 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 910348005794 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 910348005795 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 910348005796 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 910348005797 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 910348005798 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 910348005799 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 910348005800 active site 910348005801 putative transporter; Provisional; Region: PRK11660 910348005802 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 910348005803 Sulfate transporter family; Region: Sulfate_transp; pfam00916 910348005804 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 910348005805 hypothetical protein; Provisional; Region: PRK10692 910348005806 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 910348005807 putative active site [active] 910348005808 catalytic residue [active] 910348005809 GTP-binding protein YchF; Reviewed; Region: PRK09601 910348005810 YchF GTPase; Region: YchF; cd01900 910348005811 G1 box; other site 910348005812 GTP/Mg2+ binding site [chemical binding]; other site 910348005813 Switch I region; other site 910348005814 G2 box; other site 910348005815 Switch II region; other site 910348005816 G3 box; other site 910348005817 G4 box; other site 910348005818 G5 box; other site 910348005819 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 910348005820 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 910348005821 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 910348005822 Autotransporter beta-domain; Region: Autotransporter; pfam03797 910348005823 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 910348005824 PAS domain; Region: PAS; smart00091 910348005825 putative active site [active] 910348005826 heme pocket [chemical binding]; other site 910348005827 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348005828 Walker A motif; other site 910348005829 ATP binding site [chemical binding]; other site 910348005830 Walker B motif; other site 910348005831 arginine finger; other site 910348005832 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 910348005833 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 910348005834 Dak1 domain; Region: Dak1; pfam02733 910348005835 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 910348005836 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 910348005837 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 910348005838 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 910348005839 dimerization domain swap beta strand [polypeptide binding]; other site 910348005840 regulatory protein interface [polypeptide binding]; other site 910348005841 active site 910348005842 regulatory phosphorylation site [posttranslational modification]; other site 910348005843 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 910348005844 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 910348005845 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 910348005846 trehalase; Provisional; Region: treA; PRK13271 910348005847 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 910348005848 Flagellar regulator YcgR; Region: YcgR; pfam07317 910348005849 PilZ domain; Region: PilZ; pfam07238 910348005850 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 910348005851 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 910348005852 N-acetyl-D-glucosamine binding site [chemical binding]; other site 910348005853 catalytic residue [active] 910348005854 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 910348005855 dimer interface [polypeptide binding]; other site 910348005856 catalytic triad [active] 910348005857 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 910348005858 TrkA-C domain; Region: TrkA_C; pfam02080 910348005859 Transporter associated domain; Region: CorC_HlyC; smart01091 910348005860 alanine racemase; Reviewed; Region: dadX; PRK03646 910348005861 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 910348005862 active site 910348005863 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 910348005864 substrate binding site [chemical binding]; other site 910348005865 catalytic residues [active] 910348005866 dimer interface [polypeptide binding]; other site 910348005867 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 910348005868 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 910348005869 SpoVR family protein; Provisional; Region: PRK11767 910348005870 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 910348005871 fatty acid metabolism regulator; Provisional; Region: PRK04984 910348005872 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 910348005873 DNA-binding site [nucleotide binding]; DNA binding site 910348005874 FadR C-terminal domain; Region: FadR_C; pfam07840 910348005875 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 910348005876 transmembrane helices; other site 910348005877 disulfide bond formation protein B; Provisional; Region: PRK01749 910348005878 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 910348005879 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 910348005880 active site 910348005881 DNA binding site [nucleotide binding] 910348005882 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 910348005883 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 910348005884 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 910348005885 Catalytic site [active] 910348005886 hemolysin E; Provisional; Region: hlyE; PRK11376 910348005887 hypothetical protein; Provisional; Region: PRK05170 910348005888 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 910348005889 hypothetical protein; Provisional; Region: PRK10691 910348005890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 910348005891 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 910348005892 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 910348005893 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 910348005894 septum formation inhibitor; Reviewed; Region: minC; PRK03511 910348005895 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 910348005896 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 910348005897 cell division inhibitor MinD; Provisional; Region: PRK10818 910348005898 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 910348005899 Switch I; other site 910348005900 Switch II; other site 910348005901 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 910348005902 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 910348005903 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348005904 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 910348005905 transcriptional regulator MirA; Provisional; Region: PRK15043 910348005906 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 910348005907 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 910348005908 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 910348005909 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348005910 anti-adapter protein IraM; Provisional; Region: PRK09919 910348005911 isocitrate dehydrogenase; Validated; Region: PRK07362 910348005912 isocitrate dehydrogenase; Reviewed; Region: PRK07006 910348005913 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 910348005914 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 910348005915 probable active site [active] 910348005916 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 910348005917 nudix motif; other site 910348005918 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 910348005919 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 910348005920 putative lysogenization regulator; Reviewed; Region: PRK00218 910348005921 adenylosuccinate lyase; Provisional; Region: PRK09285 910348005922 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 910348005923 tetramer interface [polypeptide binding]; other site 910348005924 active site 910348005925 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 910348005926 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348005927 active site 910348005928 phosphorylation site [posttranslational modification] 910348005929 intermolecular recognition site; other site 910348005930 dimerization interface [polypeptide binding]; other site 910348005931 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 910348005932 DNA binding site [nucleotide binding] 910348005933 sensor protein PhoQ; Provisional; Region: PRK10815 910348005934 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 910348005935 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 910348005936 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 910348005937 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348005938 ATP binding site [chemical binding]; other site 910348005939 Mg2+ binding site [ion binding]; other site 910348005940 G-X-G motif; other site 910348005941 Uncharacterized conserved protein [Function unknown]; Region: COG2850 910348005942 Cupin-like domain; Region: Cupin_8; pfam13621 910348005943 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 910348005944 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 910348005945 metal binding site [ion binding]; metal-binding site 910348005946 dimer interface [polypeptide binding]; other site 910348005947 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 910348005948 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 910348005949 Walker A/P-loop; other site 910348005950 ATP binding site [chemical binding]; other site 910348005951 Q-loop/lid; other site 910348005952 ABC transporter signature motif; other site 910348005953 Walker B; other site 910348005954 D-loop; other site 910348005955 H-loop/switch region; other site 910348005956 TOBE domain; Region: TOBE_2; pfam08402 910348005957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348005958 dimer interface [polypeptide binding]; other site 910348005959 conserved gate region; other site 910348005960 putative PBP binding loops; other site 910348005961 ABC-ATPase subunit interface; other site 910348005962 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 910348005963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348005964 dimer interface [polypeptide binding]; other site 910348005965 conserved gate region; other site 910348005966 putative PBP binding loops; other site 910348005967 ABC-ATPase subunit interface; other site 910348005968 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 910348005969 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 910348005970 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 910348005971 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 910348005972 NAD-dependent deacetylase; Provisional; Region: PRK00481 910348005973 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 910348005974 NAD+ binding site [chemical binding]; other site 910348005975 substrate binding site [chemical binding]; other site 910348005976 Zn binding site [ion binding]; other site 910348005977 fructokinase; Reviewed; Region: PRK09557 910348005978 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 910348005979 nucleotide binding site [chemical binding]; other site 910348005980 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 910348005981 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 910348005982 FtsX-like permease family; Region: FtsX; pfam02687 910348005983 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 910348005984 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 910348005985 Walker A/P-loop; other site 910348005986 ATP binding site [chemical binding]; other site 910348005987 Q-loop/lid; other site 910348005988 ABC transporter signature motif; other site 910348005989 Walker B; other site 910348005990 D-loop; other site 910348005991 H-loop/switch region; other site 910348005992 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 910348005993 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 910348005994 FtsX-like permease family; Region: FtsX; pfam02687 910348005995 Predicted membrane protein [Function unknown]; Region: COG4763 910348005996 Acyltransferase family; Region: Acyl_transf_3; pfam01757 910348005997 transcription-repair coupling factor; Provisional; Region: PRK10689 910348005998 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 910348005999 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 910348006000 ATP binding site [chemical binding]; other site 910348006001 putative Mg++ binding site [ion binding]; other site 910348006002 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 910348006003 nucleotide binding region [chemical binding]; other site 910348006004 ATP-binding site [chemical binding]; other site 910348006005 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 910348006006 L,D-transpeptidase; Provisional; Region: PRK10260 910348006007 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 910348006008 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 910348006009 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 910348006010 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 910348006011 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 910348006012 hypothetical protein; Provisional; Region: PRK11280 910348006013 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 910348006014 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 910348006015 hypothetical protein; Provisional; Region: PRK04940 910348006016 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 910348006017 beta-hexosaminidase; Provisional; Region: PRK05337 910348006018 thiamine kinase; Provisional; Region: thiK; PRK10271 910348006019 substrate binding site [chemical binding]; other site 910348006020 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 910348006021 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 910348006022 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 910348006023 putative dimer interface [polypeptide binding]; other site 910348006024 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 910348006025 nucleotide binding site/active site [active] 910348006026 HIT family signature motif; other site 910348006027 catalytic residue [active] 910348006028 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 910348006029 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 910348006030 N-terminal plug; other site 910348006031 ligand-binding site [chemical binding]; other site 910348006032 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 910348006033 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 910348006034 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 910348006035 active site turn [active] 910348006036 phosphorylation site [posttranslational modification] 910348006037 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 910348006038 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 910348006039 active site 910348006040 DNA polymerase III subunit delta'; Validated; Region: PRK07993 910348006041 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 910348006042 thymidylate kinase; Validated; Region: tmk; PRK00698 910348006043 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 910348006044 TMP-binding site; other site 910348006045 ATP-binding site [chemical binding]; other site 910348006046 conserved hypothetical protein, YceG family; Region: TIGR00247 910348006047 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 910348006048 dimerization interface [polypeptide binding]; other site 910348006049 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 910348006050 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 910348006051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348006052 catalytic residue [active] 910348006053 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 910348006054 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 910348006055 dimer interface [polypeptide binding]; other site 910348006056 active site 910348006057 acyl carrier protein; Provisional; Region: acpP; PRK00982 910348006058 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 910348006059 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 910348006060 NAD(P) binding site [chemical binding]; other site 910348006061 homotetramer interface [polypeptide binding]; other site 910348006062 homodimer interface [polypeptide binding]; other site 910348006063 active site 910348006064 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 910348006065 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 910348006066 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 910348006067 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 910348006068 dimer interface [polypeptide binding]; other site 910348006069 active site 910348006070 CoA binding pocket [chemical binding]; other site 910348006071 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 910348006072 hypothetical protein; Provisional; Region: PRK11193 910348006073 Maf-like protein; Region: Maf; pfam02545 910348006074 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 910348006075 active site 910348006076 dimer interface [polypeptide binding]; other site 910348006077 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 910348006078 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 910348006079 RNA binding surface [nucleotide binding]; other site 910348006080 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 910348006081 active site 910348006082 Protein of unknown function (DUF2655); Region: DUF2655; pfam10848 910348006083 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 910348006084 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 910348006085 homodimer interface [polypeptide binding]; other site 910348006086 oligonucleotide binding site [chemical binding]; other site 910348006087 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 910348006088 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 910348006089 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 910348006090 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 910348006091 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 910348006092 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 910348006093 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 910348006094 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 910348006095 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 910348006096 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 910348006097 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 910348006098 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 910348006099 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 910348006100 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 910348006101 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 910348006102 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 910348006103 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 910348006104 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 910348006105 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 910348006106 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 910348006107 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 910348006108 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 910348006109 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 910348006110 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 910348006111 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 910348006112 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 910348006113 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 910348006114 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 910348006115 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 910348006116 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 910348006117 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 910348006118 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 910348006119 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 910348006120 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 910348006121 FlgN protein; Region: FlgN; cl09176 910348006122 FlgN protein; Region: FlgN; cl09176 910348006123 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 910348006124 MviN-like protein; Region: MVIN; pfam03023 910348006125 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 910348006126 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 910348006127 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 910348006128 hypothetical protein; Provisional; Region: PRK11239 910348006129 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 910348006130 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 910348006131 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 910348006132 multidrug resistance protein MdtH; Provisional; Region: PRK11646 910348006133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348006134 putative substrate translocation pore; other site 910348006135 Glutaredoxin 2 [Posttranslational modification, protein turnover, chaperones]; Region: GrxB; COG2999 910348006136 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 910348006137 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 910348006138 N-terminal domain interface [polypeptide binding]; other site 910348006139 lipoprotein; Provisional; Region: PRK10598 910348006140 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 910348006141 active site 910348006142 dimer interface [polypeptide binding]; other site 910348006143 substrate binding pocket [chemical binding]; other site 910348006144 DNA damage-inducible protein I; Provisional; Region: PRK10597 910348006145 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 910348006146 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 910348006147 hydroxyglutarate oxidase; Provisional; Region: PRK11728 910348006148 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 910348006149 hypothetical protein; Provisional; Region: PRK03757 910348006150 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 910348006151 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 910348006152 active site residue [active] 910348006153 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 910348006154 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 910348006155 putative acyl-acceptor binding pocket; other site 910348006156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348006157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348006158 secY/secA suppressor protein; Provisional; Region: PRK11467 910348006159 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 910348006160 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 910348006161 Ligand binding site; other site 910348006162 DXD motif; other site 910348006163 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 910348006164 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 910348006165 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 910348006166 Acyltransferase family; Region: Acyl_transf_3; pfam01757 910348006167 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 910348006168 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 910348006169 putative active site [active] 910348006170 catalytic site [active] 910348006171 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 910348006172 putative active site [active] 910348006173 catalytic site [active] 910348006174 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 910348006175 putative ADP-ribose binding site [chemical binding]; other site 910348006176 putative active site [active] 910348006177 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 910348006178 major curlin subunit; Provisional; Region: csgA; PRK10051 910348006179 Curlin associated repeat; Region: Curlin_rpt; pfam07012 910348006180 Curlin associated repeat; Region: Curlin_rpt; pfam07012 910348006181 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 910348006182 Curlin associated repeat; Region: Curlin_rpt; pfam07012 910348006183 Curlin associated repeat; Region: Curlin_rpt; pfam07012 910348006184 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348006185 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 910348006186 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 910348006187 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 910348006188 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 910348006189 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 910348006190 DNA binding residues [nucleotide binding] 910348006191 dimerization interface [polypeptide binding]; other site 910348006192 curli assembly protein CsgE; Provisional; Region: PRK10386 910348006193 curli assembly protein CsgF; Provisional; Region: PRK10050 910348006194 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 910348006195 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 910348006196 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 910348006197 putative hydrolase; Validated; Region: PRK09248 910348006198 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 910348006199 active site 910348006200 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 910348006201 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 910348006202 putative ligand binding site [chemical binding]; other site 910348006203 NAD binding site [chemical binding]; other site 910348006204 dimerization interface [polypeptide binding]; other site 910348006205 catalytic site [active] 910348006206 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 910348006207 Transposase; Region: HTH_Tnp_1; cl17663 910348006208 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 910348006209 putative transposase OrfB; Reviewed; Region: PHA02517 910348006210 HTH-like domain; Region: HTH_21; pfam13276 910348006211 Integrase core domain; Region: rve; pfam00665 910348006212 Integrase core domain; Region: rve_2; pfam13333 910348006213 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 910348006214 Helix-turn-helix domain; Region: HTH_38; pfam13936 910348006215 Integrase core domain; Region: rve; pfam00665 910348006216 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 910348006217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 910348006218 Protein of unknown function, DUF606; Region: DUF606; pfam04657 910348006219 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 910348006220 active site 910348006221 substrate binding pocket [chemical binding]; other site 910348006222 homodimer interaction site [polypeptide binding]; other site 910348006223 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 910348006224 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 910348006225 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 910348006226 Transposase; Region: DDE_Tnp_ISL3; pfam01610 910348006227 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 910348006228 Transposase; Region: DDE_Tnp_ISL3; pfam01610 910348006229 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 910348006230 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 910348006231 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 910348006232 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 910348006233 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 910348006234 transposase/IS protein; Provisional; Region: PRK09183 910348006235 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348006236 Walker A motif; other site 910348006237 ATP binding site [chemical binding]; other site 910348006238 Walker B motif; other site 910348006239 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 910348006240 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 910348006241 DNA-binding interface [nucleotide binding]; DNA binding site 910348006242 Integrase core domain; Region: rve; pfam00665 910348006243 hypothetical protein; Provisional; Region: PRK09866 910348006244 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 910348006245 G1 box; other site 910348006246 GTP/Mg2+ binding site [chemical binding]; other site 910348006247 G2 box; other site 910348006248 Switch I region; other site 910348006249 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 910348006250 G3 box; other site 910348006251 Switch II region; other site 910348006252 GTP/Mg2+ binding site [chemical binding]; other site 910348006253 G4 box; other site 910348006254 G5 box; other site 910348006255 YjcZ-like protein; Region: YjcZ; pfam13990 910348006256 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 910348006257 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 910348006258 nucleophile elbow; other site 910348006259 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 910348006260 Domain of unknown function (DUF932); Region: DUF932; pfam06067 910348006261 Antirestriction protein; Region: Antirestrict; pfam03230 910348006262 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 910348006263 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 910348006264 MPN+ (JAMM) motif; other site 910348006265 Zinc-binding site [ion binding]; other site 910348006266 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 910348006267 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 910348006268 Switch II region; other site 910348006269 G4 box; other site 910348006270 G5 box; other site 910348006271 hypothetical protein; Provisional; Region: PRK05423 910348006272 Predicted membrane protein [Function unknown]; Region: COG1289 910348006273 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 910348006274 DNA gyrase inhibitor; Provisional; Region: PRK10016 910348006275 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 910348006276 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 910348006277 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 910348006278 exonuclease I; Provisional; Region: sbcB; PRK11779 910348006279 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 910348006280 active site 910348006281 catalytic site [active] 910348006282 substrate binding site [chemical binding]; other site 910348006283 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 910348006284 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 910348006285 Sulphur transport; Region: Sulf_transp; pfam04143 910348006286 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 910348006287 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348006288 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 910348006289 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 910348006290 dimerization interface [polypeptide binding]; other site 910348006291 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 910348006292 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 910348006293 putative NAD(P) binding site [chemical binding]; other site 910348006294 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 910348006295 antitoxin YefM; Provisional; Region: PRK11409 910348006296 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 910348006297 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 910348006298 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 910348006299 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 910348006300 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 910348006301 NAD binding site [chemical binding]; other site 910348006302 dimerization interface [polypeptide binding]; other site 910348006303 product binding site; other site 910348006304 substrate binding site [chemical binding]; other site 910348006305 zinc binding site [ion binding]; other site 910348006306 catalytic residues [active] 910348006307 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 910348006308 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 910348006309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348006310 homodimer interface [polypeptide binding]; other site 910348006311 catalytic residue [active] 910348006312 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 910348006313 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 910348006314 active site 910348006315 motif I; other site 910348006316 motif II; other site 910348006317 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 910348006318 putative active site pocket [active] 910348006319 4-fold oligomerization interface [polypeptide binding]; other site 910348006320 metal binding residues [ion binding]; metal-binding site 910348006321 3-fold/trimer interface [polypeptide binding]; other site 910348006322 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 910348006323 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 910348006324 putative active site [active] 910348006325 oxyanion strand; other site 910348006326 catalytic triad [active] 910348006327 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 910348006328 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 910348006329 catalytic residues [active] 910348006330 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 910348006331 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 910348006332 substrate binding site [chemical binding]; other site 910348006333 glutamase interaction surface [polypeptide binding]; other site 910348006334 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 910348006335 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 910348006336 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 910348006337 metal binding site [ion binding]; metal-binding site 910348006338 chain length determinant protein WzzB; Provisional; Region: PRK15471 910348006339 Chain length determinant protein; Region: Wzz; pfam02706 910348006340 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 910348006341 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 910348006342 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 910348006343 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 910348006344 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 910348006345 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 910348006346 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 910348006347 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 910348006348 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 910348006349 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 910348006350 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 910348006351 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 910348006352 active site 910348006353 homodimer interface [polypeptide binding]; other site 910348006354 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 910348006355 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 910348006356 putative NAD(P) binding site [chemical binding]; other site 910348006357 active site 910348006358 putative substrate binding site [chemical binding]; other site 910348006359 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 910348006360 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 910348006361 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 910348006362 NAD(P) binding site [chemical binding]; other site 910348006363 homodimer interface [polypeptide binding]; other site 910348006364 substrate binding site [chemical binding]; other site 910348006365 active site 910348006366 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 910348006367 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 910348006368 active site 910348006369 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 910348006370 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 910348006371 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 910348006372 Transposase [DNA replication, recombination, and repair]; Region: COG5433 910348006373 Transposase [DNA replication, recombination, and repair]; Region: COG5433 910348006374 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 910348006375 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 910348006376 Transposase [DNA replication, recombination, and repair]; Region: COG5433 910348006377 Transposase [DNA replication, recombination, and repair]; Region: COG5433 910348006378 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 910348006379 active site 910348006380 tetramer interface; other site 910348006381 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 910348006382 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 910348006383 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 910348006384 putative ADP-binding pocket [chemical binding]; other site 910348006385 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 910348006386 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 910348006387 colanic acid exporter; Provisional; Region: PRK10459 910348006388 colanic acid exporter; Provisional; Region: PRK10459 910348006389 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 910348006390 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 910348006391 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 910348006392 phosphomannomutase CpsG; Provisional; Region: PRK15414 910348006393 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 910348006394 active site 910348006395 substrate binding site [chemical binding]; other site 910348006396 metal binding site [ion binding]; metal-binding site 910348006397 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 910348006398 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 910348006399 Substrate binding site; other site 910348006400 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 910348006401 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 910348006402 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 910348006403 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 910348006404 active site 910348006405 GDP-Mannose binding site [chemical binding]; other site 910348006406 dimer interface [polypeptide binding]; other site 910348006407 modified nudix motif 910348006408 metal binding site [ion binding]; metal-binding site 910348006409 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 910348006410 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 910348006411 NADP binding site [chemical binding]; other site 910348006412 active site 910348006413 putative substrate binding site [chemical binding]; other site 910348006414 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 910348006415 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 910348006416 NADP-binding site; other site 910348006417 homotetramer interface [polypeptide binding]; other site 910348006418 substrate binding site [chemical binding]; other site 910348006419 homodimer interface [polypeptide binding]; other site 910348006420 active site 910348006421 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 910348006422 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 910348006423 putative trimer interface [polypeptide binding]; other site 910348006424 putative active site [active] 910348006425 putative substrate binding site [chemical binding]; other site 910348006426 putative CoA binding site [chemical binding]; other site 910348006427 putative glycosyl transferase; Provisional; Region: PRK10063 910348006428 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 910348006429 metal-binding site 910348006430 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 910348006431 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 910348006432 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 910348006433 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 910348006434 putative acyl transferase; Provisional; Region: PRK10191 910348006435 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 910348006436 trimer interface [polypeptide binding]; other site 910348006437 active site 910348006438 substrate binding site [chemical binding]; other site 910348006439 CoA binding site [chemical binding]; other site 910348006440 putative glycosyl transferase; Provisional; Region: PRK10018 910348006441 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 910348006442 active site 910348006443 tyrosine kinase; Provisional; Region: PRK11519 910348006444 Chain length determinant protein; Region: Wzz; pfam02706 910348006445 Chain length determinant protein; Region: Wzz; cl15801 910348006446 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 910348006447 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 910348006448 Low molecular weight phosphatase family; Region: LMWPc; cd00115 910348006449 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 910348006450 active site 910348006451 polysaccharide export protein Wza; Provisional; Region: PRK15078 910348006452 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 910348006453 SLBB domain; Region: SLBB; pfam10531 910348006454 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 910348006455 FOG: CBS domain [General function prediction only]; Region: COG0517 910348006456 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 910348006457 Transporter associated domain; Region: CorC_HlyC; smart01091 910348006458 putative assembly protein; Provisional; Region: PRK10833 910348006459 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 910348006460 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 910348006461 trimer interface [polypeptide binding]; other site 910348006462 active site 910348006463 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 910348006464 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 910348006465 ATP-binding site [chemical binding]; other site 910348006466 Sugar specificity; other site 910348006467 Pyrimidine base specificity; other site 910348006468 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 910348006469 putative diguanylate cyclase; Provisional; Region: PRK09776 910348006470 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 910348006471 putative active site [active] 910348006472 heme pocket [chemical binding]; other site 910348006473 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 910348006474 putative active site [active] 910348006475 heme pocket [chemical binding]; other site 910348006476 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 910348006477 putative active site [active] 910348006478 heme pocket [chemical binding]; other site 910348006479 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 910348006480 metal binding site [ion binding]; metal-binding site 910348006481 active site 910348006482 I-site; other site 910348006483 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 910348006484 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 910348006485 AlkA N-terminal domain; Region: AlkA_N; smart01009 910348006486 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 910348006487 minor groove reading motif; other site 910348006488 helix-hairpin-helix signature motif; other site 910348006489 substrate binding pocket [chemical binding]; other site 910348006490 active site 910348006491 putative chaperone; Provisional; Region: PRK11678 910348006492 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 910348006493 putative NEF/HSP70 interaction site [polypeptide binding]; other site 910348006494 nucleotide binding site [chemical binding]; other site 910348006495 SBD interface [polypeptide binding]; other site 910348006496 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 910348006497 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 910348006498 substrate binding site [chemical binding]; other site 910348006499 activation loop (A-loop); other site 910348006500 Y-family of DNA polymerases; Region: PolY; cl12025 910348006501 Protein phosphatase 2C; Region: PP2C_2; pfam13672 910348006502 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 910348006503 metal ion-dependent adhesion site (MIDAS); other site 910348006504 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 910348006505 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 910348006506 HlyD family secretion protein; Region: HlyD_3; pfam13437 910348006507 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 910348006508 Protein export membrane protein; Region: SecD_SecF; cl14618 910348006509 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 910348006510 putative transporter; Provisional; Region: PRK10504 910348006511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348006512 putative substrate translocation pore; other site 910348006513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348006514 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 910348006515 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 910348006516 dimerization interface [polypeptide binding]; other site 910348006517 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 910348006518 dimer interface [polypeptide binding]; other site 910348006519 phosphorylation site [posttranslational modification] 910348006520 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348006521 ATP binding site [chemical binding]; other site 910348006522 Mg2+ binding site [ion binding]; other site 910348006523 G-X-G motif; other site 910348006524 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 910348006525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348006526 active site 910348006527 phosphorylation site [posttranslational modification] 910348006528 intermolecular recognition site; other site 910348006529 dimerization interface [polypeptide binding]; other site 910348006530 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 910348006531 DNA binding site [nucleotide binding] 910348006532 Uncharacterized conserved protein [Function unknown]; Region: COG3422 910348006533 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 910348006534 putative protease; Provisional; Region: PRK15452 910348006535 Peptidase family U32; Region: Peptidase_U32; pfam01136 910348006536 lipid kinase; Reviewed; Region: PRK13054 910348006537 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 910348006538 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 910348006539 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 910348006540 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 910348006541 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 910348006542 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 910348006543 putative NAD(P) binding site [chemical binding]; other site 910348006544 catalytic Zn binding site [ion binding]; other site 910348006545 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 910348006546 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 910348006547 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 910348006548 active site 910348006549 P-loop; other site 910348006550 phosphorylation site [posttranslational modification] 910348006551 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 910348006552 active site 910348006553 phosphorylation site [posttranslational modification] 910348006554 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 910348006555 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 910348006556 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 910348006557 intersubunit interface [polypeptide binding]; other site 910348006558 active site 910348006559 zinc binding site [ion binding]; other site 910348006560 Na+ binding site [ion binding]; other site 910348006561 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 910348006562 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 910348006563 putative active site; other site 910348006564 catalytic residue [active] 910348006565 nucleoside transporter; Region: 2A0110; TIGR00889 910348006566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348006567 putative substrate translocation pore; other site 910348006568 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 910348006569 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 910348006570 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 910348006571 substrate binding site [chemical binding]; other site 910348006572 ATP binding site [chemical binding]; other site 910348006573 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 910348006574 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 910348006575 DNA-binding site [nucleotide binding]; DNA binding site 910348006576 UTRA domain; Region: UTRA; pfam07702 910348006577 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 910348006578 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 910348006579 active site 910348006580 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 910348006581 dimer interface [polypeptide binding]; other site 910348006582 substrate binding site [chemical binding]; other site 910348006583 ATP binding site [chemical binding]; other site 910348006584 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 910348006585 substrate binding site [chemical binding]; other site 910348006586 multimerization interface [polypeptide binding]; other site 910348006587 ATP binding site [chemical binding]; other site 910348006588 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 910348006589 putative metal binding site [ion binding]; other site 910348006590 putative homodimer interface [polypeptide binding]; other site 910348006591 putative homotetramer interface [polypeptide binding]; other site 910348006592 putative homodimer-homodimer interface [polypeptide binding]; other site 910348006593 putative allosteric switch controlling residues; other site 910348006594 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 910348006595 Predicted integral membrane protein [Function unknown]; Region: COG5455 910348006596 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 910348006597 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 910348006598 potential frameshift: common BLAST hit: gi|238901295|ref|YP_002927091.1| putative outer membrane protein 910348006599 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 910348006600 PapC C-terminal domain; Region: PapC_C; pfam13953 910348006601 PapC N-terminal domain; Region: PapC_N; pfam13954 910348006602 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 910348006603 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 910348006604 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 910348006605 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 910348006606 antiporter inner membrane protein; Provisional; Region: PRK11670 910348006607 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 910348006608 Walker A motif; other site 910348006609 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 910348006610 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 910348006611 active site 910348006612 HIGH motif; other site 910348006613 KMSKS motif; other site 910348006614 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 910348006615 tRNA binding surface [nucleotide binding]; other site 910348006616 anticodon binding site; other site 910348006617 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 910348006618 dimer interface [polypeptide binding]; other site 910348006619 putative tRNA-binding site [nucleotide binding]; other site 910348006620 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 910348006621 MoxR-like ATPases [General function prediction only]; Region: COG0714 910348006622 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348006623 Walker A motif; other site 910348006624 ATP binding site [chemical binding]; other site 910348006625 Walker B motif; other site 910348006626 arginine finger; other site 910348006627 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 910348006628 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 910348006629 metal ion-dependent adhesion site (MIDAS); other site 910348006630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 910348006631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 910348006632 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 910348006633 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 910348006634 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 910348006635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348006636 active site 910348006637 phosphorylation site [posttranslational modification] 910348006638 intermolecular recognition site; other site 910348006639 dimerization interface [polypeptide binding]; other site 910348006640 LytTr DNA-binding domain; Region: LytTR; pfam04397 910348006641 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 910348006642 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 910348006643 GAF domain; Region: GAF; pfam01590 910348006644 Histidine kinase; Region: His_kinase; pfam06580 910348006645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348006646 ATP binding site [chemical binding]; other site 910348006647 Mg2+ binding site [ion binding]; other site 910348006648 G-X-G motif; other site 910348006649 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 910348006650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348006651 dimer interface [polypeptide binding]; other site 910348006652 conserved gate region; other site 910348006653 putative PBP binding loops; other site 910348006654 ABC-ATPase subunit interface; other site 910348006655 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 910348006656 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 910348006657 Walker A/P-loop; other site 910348006658 ATP binding site [chemical binding]; other site 910348006659 Q-loop/lid; other site 910348006660 ABC transporter signature motif; other site 910348006661 Walker B; other site 910348006662 D-loop; other site 910348006663 H-loop/switch region; other site 910348006664 CBS domain; Region: CBS; pfam00571 910348006665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348006666 dimer interface [polypeptide binding]; other site 910348006667 conserved gate region; other site 910348006668 ABC-ATPase subunit interface; other site 910348006669 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 910348006670 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 910348006671 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 910348006672 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 910348006673 D-lactate dehydrogenase; Provisional; Region: PRK11183 910348006674 FAD binding domain; Region: FAD_binding_4; pfam01565 910348006675 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 910348006676 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 910348006677 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 910348006678 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 910348006679 oxidoreductase; Provisional; Region: PRK12743 910348006680 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 910348006681 NAD(P) binding site [chemical binding]; other site 910348006682 active site 910348006683 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 910348006684 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 910348006685 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 910348006686 FMN binding site [chemical binding]; other site 910348006687 active site 910348006688 catalytic residues [active] 910348006689 substrate binding site [chemical binding]; other site 910348006690 hypothetical protein; Provisional; Region: PRK01821 910348006691 hypothetical protein; Provisional; Region: PRK10711 910348006692 cytidine deaminase; Provisional; Region: PRK09027 910348006693 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 910348006694 active site 910348006695 catalytic motif [active] 910348006696 Zn binding site [ion binding]; other site 910348006697 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 910348006698 active site 910348006699 catalytic motif [active] 910348006700 Zn binding site [ion binding]; other site 910348006701 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 910348006702 putative active site [active] 910348006703 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 910348006704 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 910348006705 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 910348006706 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 910348006707 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 910348006708 homodimer interface [polypeptide binding]; other site 910348006709 active site 910348006710 FMN binding site [chemical binding]; other site 910348006711 substrate binding site [chemical binding]; other site 910348006712 4Fe-4S binding domain; Region: Fer4; pfam00037 910348006713 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 910348006714 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 910348006715 TM-ABC transporter signature motif; other site 910348006716 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 910348006717 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 910348006718 Walker A/P-loop; other site 910348006719 ATP binding site [chemical binding]; other site 910348006720 Q-loop/lid; other site 910348006721 ABC transporter signature motif; other site 910348006722 Walker B; other site 910348006723 D-loop; other site 910348006724 H-loop/switch region; other site 910348006725 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 910348006726 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 910348006727 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 910348006728 ligand binding site [chemical binding]; other site 910348006729 calcium binding site [ion binding]; other site 910348006730 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 910348006731 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 910348006732 DNA binding site [nucleotide binding] 910348006733 domain linker motif; other site 910348006734 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 910348006735 dimerization interface (closed form) [polypeptide binding]; other site 910348006736 ligand binding site [chemical binding]; other site 910348006737 Predicted membrane protein [Function unknown]; Region: COG2311 910348006738 hypothetical protein; Provisional; Region: PRK10835 910348006739 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 910348006740 homodecamer interface [polypeptide binding]; other site 910348006741 GTP cyclohydrolase I; Provisional; Region: PLN03044 910348006742 active site 910348006743 putative catalytic site residues [active] 910348006744 zinc binding site [ion binding]; other site 910348006745 GTP-CH-I/GFRP interaction surface; other site 910348006746 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 910348006747 S-formylglutathione hydrolase; Region: PLN02442 910348006748 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 910348006749 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 910348006750 N-terminal plug; other site 910348006751 ligand-binding site [chemical binding]; other site 910348006752 lysine transporter; Provisional; Region: PRK10836 910348006753 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 910348006754 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348006755 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 910348006756 putative dimerization interface [polypeptide binding]; other site 910348006757 conserved hypothetical integral membrane protein; Region: TIGR00698 910348006758 endonuclease IV; Provisional; Region: PRK01060 910348006759 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 910348006760 AP (apurinic/apyrimidinic) site pocket; other site 910348006761 DNA interaction; other site 910348006762 Metal-binding active site; metal-binding site 910348006763 putative kinase; Provisional; Region: PRK09954 910348006764 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 910348006765 putative DNA binding site [nucleotide binding]; other site 910348006766 putative Zn2+ binding site [ion binding]; other site 910348006767 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 910348006768 substrate binding site [chemical binding]; other site 910348006769 ATP binding site [chemical binding]; other site 910348006770 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 910348006771 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 910348006772 Nucleoside recognition; Region: Gate; pfam07670 910348006773 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 910348006774 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 910348006775 active site 910348006776 tetramer interface [polypeptide binding]; other site 910348006777 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 910348006778 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 910348006779 ligand binding site [chemical binding]; other site 910348006780 flexible hinge region; other site 910348006781 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 910348006782 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 910348006783 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 910348006784 Nucleoside recognition; Region: Gate; pfam07670 910348006785 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 910348006786 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 910348006787 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 910348006788 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 910348006789 substrate binding site [chemical binding]; other site 910348006790 ATP binding site [chemical binding]; other site 910348006791 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 910348006792 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 910348006793 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 910348006794 active site 910348006795 P-loop; other site 910348006796 phosphorylation site [posttranslational modification] 910348006797 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 910348006798 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 910348006799 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 910348006800 putative substrate binding site [chemical binding]; other site 910348006801 putative ATP binding site [chemical binding]; other site 910348006802 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 910348006803 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 910348006804 active site 910348006805 phosphorylation site [posttranslational modification] 910348006806 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 910348006807 dimerization domain swap beta strand [polypeptide binding]; other site 910348006808 regulatory protein interface [polypeptide binding]; other site 910348006809 active site 910348006810 regulatory phosphorylation site [posttranslational modification]; other site 910348006811 sugar efflux transporter B; Provisional; Region: PRK15011 910348006812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348006813 putative substrate translocation pore; other site 910348006814 Flagellin N-methylase; Region: FliB; pfam03692 910348006815 elongation factor P; Provisional; Region: PRK04542 910348006816 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 910348006817 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 910348006818 RNA binding site [nucleotide binding]; other site 910348006819 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 910348006820 RNA binding site [nucleotide binding]; other site 910348006821 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 910348006822 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 910348006823 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 910348006824 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 910348006825 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 910348006826 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 910348006827 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 910348006828 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 910348006829 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 910348006830 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 910348006831 active site 910348006832 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 910348006833 NlpC/P60 family; Region: NLPC_P60; pfam00877 910348006834 phage resistance protein; Provisional; Region: PRK10551 910348006835 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 910348006836 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 910348006837 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 910348006838 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 910348006839 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 910348006840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348006841 dimer interface [polypeptide binding]; other site 910348006842 conserved gate region; other site 910348006843 putative PBP binding loops; other site 910348006844 ABC-ATPase subunit interface; other site 910348006845 microcin C ABC transporter permease; Provisional; Region: PRK15021 910348006846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348006847 dimer interface [polypeptide binding]; other site 910348006848 conserved gate region; other site 910348006849 ABC-ATPase subunit interface; other site 910348006850 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 910348006851 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 910348006852 Walker A/P-loop; other site 910348006853 ATP binding site [chemical binding]; other site 910348006854 Q-loop/lid; other site 910348006855 ABC transporter signature motif; other site 910348006856 Walker B; other site 910348006857 D-loop; other site 910348006858 H-loop/switch region; other site 910348006859 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 910348006860 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 910348006861 Walker A/P-loop; other site 910348006862 ATP binding site [chemical binding]; other site 910348006863 Q-loop/lid; other site 910348006864 ABC transporter signature motif; other site 910348006865 Walker B; other site 910348006866 D-loop; other site 910348006867 H-loop/switch region; other site 910348006868 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 910348006869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348006870 putative substrate translocation pore; other site 910348006871 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 910348006872 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 910348006873 RNA binding surface [nucleotide binding]; other site 910348006874 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 910348006875 active site 910348006876 uracil binding [chemical binding]; other site 910348006877 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 910348006878 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 910348006879 ATP binding site [chemical binding]; other site 910348006880 putative Mg++ binding site [ion binding]; other site 910348006881 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 910348006882 nucleotide binding region [chemical binding]; other site 910348006883 ATP-binding site [chemical binding]; other site 910348006884 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 910348006885 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 910348006886 5S rRNA interface [nucleotide binding]; other site 910348006887 CTC domain interface [polypeptide binding]; other site 910348006888 L16 interface [polypeptide binding]; other site 910348006889 Nucleoid-associated protein [General function prediction only]; Region: COG3081 910348006890 nucleoid-associated protein NdpA; Validated; Region: PRK00378 910348006891 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 910348006892 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 910348006893 Sulfatase; Region: Sulfatase; pfam00884 910348006894 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 910348006895 hypothetical protein; Provisional; Region: PRK09945 910348006896 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 910348006897 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 910348006898 Autotransporter beta-domain; Region: Autotransporter; pfam03797 910348006899 transcriptional regulator NarP; Provisional; Region: PRK10403 910348006900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348006901 active site 910348006902 phosphorylation site [posttranslational modification] 910348006903 intermolecular recognition site; other site 910348006904 dimerization interface [polypeptide binding]; other site 910348006905 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 910348006906 DNA binding residues [nucleotide binding] 910348006907 dimerization interface [polypeptide binding]; other site 910348006908 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 910348006909 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 910348006910 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 910348006911 binding surface 910348006912 TPR motif; other site 910348006913 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 910348006914 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 910348006915 catalytic residues [active] 910348006916 central insert; other site 910348006917 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 910348006918 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 910348006919 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 910348006920 heme exporter protein CcmC; Region: ccmC; TIGR01191 910348006921 heme exporter protein CcmB; Region: ccmB; TIGR01190 910348006922 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 910348006923 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 910348006924 Walker A/P-loop; other site 910348006925 ATP binding site [chemical binding]; other site 910348006926 Q-loop/lid; other site 910348006927 ABC transporter signature motif; other site 910348006928 Walker B; other site 910348006929 D-loop; other site 910348006930 H-loop/switch region; other site 910348006931 cytochrome c-type protein NapC; Provisional; Region: PRK10617 910348006932 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 910348006933 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 910348006934 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 910348006935 4Fe-4S binding domain; Region: Fer4_5; pfam12801 910348006936 4Fe-4S binding domain; Region: Fer4_6; pfam12837 910348006937 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 910348006938 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 910348006939 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 910348006940 [4Fe-4S] binding site [ion binding]; other site 910348006941 molybdopterin cofactor binding site; other site 910348006942 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 910348006943 molybdopterin cofactor binding site; other site 910348006944 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 910348006945 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 910348006946 malate:quinone oxidoreductase; Validated; Region: PRK05257 910348006947 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 910348006948 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 910348006949 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 910348006950 Walker A/P-loop; other site 910348006951 ATP binding site [chemical binding]; other site 910348006952 Q-loop/lid; other site 910348006953 ABC transporter signature motif; other site 910348006954 Walker B; other site 910348006955 D-loop; other site 910348006956 H-loop/switch region; other site 910348006957 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 910348006958 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 910348006959 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348006960 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 910348006961 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348006962 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 910348006963 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 910348006964 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 910348006965 DNA binding site [nucleotide binding] 910348006966 active site 910348006967 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 910348006968 ApbE family; Region: ApbE; pfam02424 910348006969 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 910348006970 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 910348006971 trimer interface [polypeptide binding]; other site 910348006972 eyelet of channel; other site 910348006973 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 910348006974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348006975 ATP binding site [chemical binding]; other site 910348006976 G-X-G motif; other site 910348006977 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 910348006978 putative binding surface; other site 910348006979 active site 910348006980 transcriptional regulator RcsB; Provisional; Region: PRK10840 910348006981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348006982 active site 910348006983 phosphorylation site [posttranslational modification] 910348006984 intermolecular recognition site; other site 910348006985 dimerization interface [polypeptide binding]; other site 910348006986 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 910348006987 DNA binding residues [nucleotide binding] 910348006988 dimerization interface [polypeptide binding]; other site 910348006989 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 910348006990 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 910348006991 dimer interface [polypeptide binding]; other site 910348006992 phosphorylation site [posttranslational modification] 910348006993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348006994 ATP binding site [chemical binding]; other site 910348006995 Mg2+ binding site [ion binding]; other site 910348006996 G-X-G motif; other site 910348006997 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 910348006998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348006999 active site 910348007000 phosphorylation site [posttranslational modification] 910348007001 intermolecular recognition site; other site 910348007002 dimerization interface [polypeptide binding]; other site 910348007003 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 910348007004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348007005 active site 910348007006 phosphorylation site [posttranslational modification] 910348007007 intermolecular recognition site; other site 910348007008 dimerization interface [polypeptide binding]; other site 910348007009 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348007010 Walker A motif; other site 910348007011 ATP binding site [chemical binding]; other site 910348007012 Walker B motif; other site 910348007013 arginine finger; other site 910348007014 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 910348007015 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920 910348007016 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 910348007017 Short chain fatty acid transporter; Region: SCFA_trans; cl17380 910348007018 Short chain fatty acid transporter; Region: SCFA_trans; cl17380 910348007019 putative acyltransferase; Provisional; Region: PRK05790 910348007020 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 910348007021 dimer interface [polypeptide binding]; other site 910348007022 active site 910348007023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 910348007024 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 910348007025 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 910348007026 Alpha-2-macroglobulin family; Region: A2M; pfam00207 910348007027 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 910348007028 MG2 domain; Region: A2M_N; pfam01835 910348007029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 910348007030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 910348007031 DNA gyrase subunit A; Validated; Region: PRK05560 910348007032 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 910348007033 CAP-like domain; other site 910348007034 active site 910348007035 primary dimer interface [polypeptide binding]; other site 910348007036 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 910348007037 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 910348007038 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 910348007039 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 910348007040 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 910348007041 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 910348007042 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 910348007043 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348007044 S-adenosylmethionine binding site [chemical binding]; other site 910348007045 adhesin; Provisional; Region: PRK09752 910348007046 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 910348007047 Autotransporter beta-domain; Region: Autotransporter; pfam03797 910348007048 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348007049 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 910348007050 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 910348007051 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 910348007052 adhesin; Provisional; Region: PRK09752 910348007053 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 910348007054 ATP cone domain; Region: ATP-cone; pfam03477 910348007055 Class I ribonucleotide reductase; Region: RNR_I; cd01679 910348007056 active site 910348007057 dimer interface [polypeptide binding]; other site 910348007058 catalytic residues [active] 910348007059 effector binding site; other site 910348007060 R2 peptide binding site; other site 910348007061 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 910348007062 dimer interface [polypeptide binding]; other site 910348007063 putative radical transfer pathway; other site 910348007064 diiron center [ion binding]; other site 910348007065 tyrosyl radical; other site 910348007066 hypothetical protein; Provisional; Region: PRK09902 910348007067 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 910348007068 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 910348007069 active site 910348007070 catalytic site [active] 910348007071 metal binding site [ion binding]; metal-binding site 910348007072 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 910348007073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348007074 putative substrate translocation pore; other site 910348007075 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 910348007076 hydroxyglutarate oxidase; Provisional; Region: PRK11728 910348007077 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 910348007078 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 910348007079 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 910348007080 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 910348007081 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 910348007082 Cysteine-rich domain; Region: CCG; pfam02754 910348007083 Cysteine-rich domain; Region: CCG; pfam02754 910348007084 hypothetical protein; Provisional; Region: PRK09956 910348007085 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 910348007086 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 910348007087 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 910348007088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348007089 putative substrate translocation pore; other site 910348007090 L-rhamnonate dehydratase; Provisional; Region: PRK15440 910348007091 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 910348007092 putative active site pocket [active] 910348007093 putative metal binding site [ion binding]; other site 910348007094 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 910348007095 Transcriptional regulator [Transcription]; Region: IclR; COG1414 910348007096 Bacterial transcriptional regulator; Region: IclR; pfam01614 910348007097 hypothetical protein; Provisional; Region: PRK03673 910348007098 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 910348007099 putative MPT binding site; other site 910348007100 Competence-damaged protein; Region: CinA; cl00666 910348007101 YfaZ precursor; Region: YfaZ; pfam07437 910348007102 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 910348007103 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 910348007104 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 910348007105 catalytic core [active] 910348007106 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 910348007107 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 910348007108 inhibitor-cofactor binding pocket; inhibition site 910348007109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348007110 catalytic residue [active] 910348007111 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 910348007112 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 910348007113 Ligand binding site; other site 910348007114 Putative Catalytic site; other site 910348007115 DXD motif; other site 910348007116 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 910348007117 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 910348007118 substrate binding site [chemical binding]; other site 910348007119 cosubstrate binding site; other site 910348007120 catalytic site [active] 910348007121 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 910348007122 active site 910348007123 hexamer interface [polypeptide binding]; other site 910348007124 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 910348007125 NAD binding site [chemical binding]; other site 910348007126 substrate binding site [chemical binding]; other site 910348007127 active site 910348007128 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 910348007129 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 910348007130 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 910348007131 putative active site [active] 910348007132 putative catalytic site [active] 910348007133 putative Zn binding site [ion binding]; other site 910348007134 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 910348007135 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 910348007136 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 910348007137 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 910348007138 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 910348007139 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 910348007140 acyl-activating enzyme (AAE) consensus motif; other site 910348007141 putative AMP binding site [chemical binding]; other site 910348007142 putative active site [active] 910348007143 putative CoA binding site [chemical binding]; other site 910348007144 O-succinylbenzoate synthase; Provisional; Region: PRK05105 910348007145 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 910348007146 active site 910348007147 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 910348007148 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 910348007149 substrate binding site [chemical binding]; other site 910348007150 oxyanion hole (OAH) forming residues; other site 910348007151 trimer interface [polypeptide binding]; other site 910348007152 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 910348007153 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 910348007154 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 910348007155 dimer interface [polypeptide binding]; other site 910348007156 tetramer interface [polypeptide binding]; other site 910348007157 PYR/PP interface [polypeptide binding]; other site 910348007158 TPP binding site [chemical binding]; other site 910348007159 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 910348007160 TPP-binding site; other site 910348007161 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 910348007162 isochorismate synthases; Region: isochor_syn; TIGR00543 910348007163 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 910348007164 Coenzyme A binding pocket [chemical binding]; other site 910348007165 ribonuclease BN; Region: true_RNase_BN; TIGR02649 910348007166 deubiquitinase; Provisional; Region: PRK11836 910348007167 von Willebrand factor; Region: vWF_A; pfam12450 910348007168 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 910348007169 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 910348007170 metal ion-dependent adhesion site (MIDAS); other site 910348007171 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 910348007172 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 910348007173 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 910348007174 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 910348007175 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 910348007176 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 910348007177 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 910348007178 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 910348007179 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 910348007180 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 910348007181 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 910348007182 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 910348007183 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 910348007184 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 910348007185 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 910348007186 4Fe-4S binding domain; Region: Fer4; pfam00037 910348007187 4Fe-4S binding domain; Region: Fer4; pfam00037 910348007188 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 910348007189 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 910348007190 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 910348007191 catalytic loop [active] 910348007192 iron binding site [ion binding]; other site 910348007193 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 910348007194 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 910348007195 [4Fe-4S] binding site [ion binding]; other site 910348007196 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 910348007197 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 910348007198 SLBB domain; Region: SLBB; pfam10531 910348007199 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 910348007200 NADH dehydrogenase subunit E; Validated; Region: PRK07539 910348007201 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 910348007202 putative dimer interface [polypeptide binding]; other site 910348007203 [2Fe-2S] cluster binding site [ion binding]; other site 910348007204 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 910348007205 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 910348007206 NADH dehydrogenase subunit D; Validated; Region: PRK06075 910348007207 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 910348007208 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 910348007209 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 910348007210 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348007211 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 910348007212 putative dimerization interface [polypeptide binding]; other site 910348007213 aminotransferase AlaT; Validated; Region: PRK09265 910348007214 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 910348007215 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348007216 homodimer interface [polypeptide binding]; other site 910348007217 catalytic residue [active] 910348007218 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 910348007219 Zn2+ binding site [ion binding]; other site 910348007220 Mg2+ binding site [ion binding]; other site 910348007221 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 910348007222 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 910348007223 TrkA-C domain; Region: TrkA_C; pfam02080 910348007224 TrkA-C domain; Region: TrkA_C; pfam02080 910348007225 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 910348007226 putative phosphatase; Provisional; Region: PRK11587 910348007227 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 910348007228 motif II; other site 910348007229 hypothetical protein; Validated; Region: PRK05445 910348007230 hypothetical protein; Provisional; Region: PRK01816 910348007231 propionate/acetate kinase; Provisional; Region: PRK12379 910348007232 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 910348007233 phosphate acetyltransferase; Reviewed; Region: PRK05632 910348007234 DRTGG domain; Region: DRTGG; pfam07085 910348007235 phosphate acetyltransferase; Region: pta; TIGR00651 910348007236 hypothetical protein; Provisional; Region: PRK11588 910348007237 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 910348007238 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 910348007239 active site 910348007240 metal binding site [ion binding]; metal-binding site 910348007241 homotetramer interface [polypeptide binding]; other site 910348007242 glutathione S-transferase; Provisional; Region: PRK15113 910348007243 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 910348007244 C-terminal domain interface [polypeptide binding]; other site 910348007245 GSH binding site (G-site) [chemical binding]; other site 910348007246 dimer interface [polypeptide binding]; other site 910348007247 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 910348007248 N-terminal domain interface [polypeptide binding]; other site 910348007249 putative dimer interface [polypeptide binding]; other site 910348007250 putative substrate binding pocket (H-site) [chemical binding]; other site 910348007251 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 910348007252 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 910348007253 C-terminal domain interface [polypeptide binding]; other site 910348007254 GSH binding site (G-site) [chemical binding]; other site 910348007255 dimer interface [polypeptide binding]; other site 910348007256 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 910348007257 N-terminal domain interface [polypeptide binding]; other site 910348007258 putative dimer interface [polypeptide binding]; other site 910348007259 active site 910348007260 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 910348007261 homooctamer interface [polypeptide binding]; other site 910348007262 active site 910348007263 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 910348007264 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 910348007265 putative NAD(P) binding site [chemical binding]; other site 910348007266 putative active site [active] 910348007267 putative transposase; Provisional; Region: PRK09857 910348007268 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 910348007269 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 910348007270 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 910348007271 Walker A/P-loop; other site 910348007272 ATP binding site [chemical binding]; other site 910348007273 Q-loop/lid; other site 910348007274 ABC transporter signature motif; other site 910348007275 Walker B; other site 910348007276 D-loop; other site 910348007277 H-loop/switch region; other site 910348007278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348007279 ABC-ATPase subunit interface; other site 910348007280 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 910348007281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348007282 dimer interface [polypeptide binding]; other site 910348007283 conserved gate region; other site 910348007284 putative PBP binding loops; other site 910348007285 ABC-ATPase subunit interface; other site 910348007286 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 910348007287 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 910348007288 substrate binding pocket [chemical binding]; other site 910348007289 membrane-bound complex binding site; other site 910348007290 hinge residues; other site 910348007291 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 910348007292 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 910348007293 substrate binding pocket [chemical binding]; other site 910348007294 membrane-bound complex binding site; other site 910348007295 hinge residues; other site 910348007296 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 910348007297 Flavoprotein; Region: Flavoprotein; pfam02441 910348007298 amidophosphoribosyltransferase; Provisional; Region: PRK09246 910348007299 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 910348007300 active site 910348007301 tetramer interface [polypeptide binding]; other site 910348007302 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 910348007303 active site 910348007304 colicin V production protein; Provisional; Region: PRK10845 910348007305 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 910348007306 cell division protein DedD; Provisional; Region: PRK11633 910348007307 Sporulation related domain; Region: SPOR; pfam05036 910348007308 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 910348007309 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 910348007310 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 910348007311 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 910348007312 hypothetical protein; Provisional; Region: PRK10847 910348007313 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 910348007314 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 910348007315 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 910348007316 dimerization interface 3.5A [polypeptide binding]; other site 910348007317 active site 910348007318 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 910348007319 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 910348007320 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 910348007321 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 910348007322 ligand binding site [chemical binding]; other site 910348007323 NAD binding site [chemical binding]; other site 910348007324 catalytic site [active] 910348007325 homodimer interface [polypeptide binding]; other site 910348007326 putative transporter; Provisional; Region: PRK12382 910348007327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348007328 putative substrate translocation pore; other site 910348007329 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 910348007330 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 910348007331 dimer interface [polypeptide binding]; other site 910348007332 active site 910348007333 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; pfam05430 910348007334 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 910348007335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 910348007336 hypothetical protein; Provisional; Region: PRK10621 910348007337 Predicted permeases [General function prediction only]; Region: COG0730 910348007338 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 910348007339 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 910348007340 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 910348007341 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 910348007342 Tetramer interface [polypeptide binding]; other site 910348007343 active site 910348007344 FMN-binding site [chemical binding]; other site 910348007345 HemK family putative methylases; Region: hemK_fam; TIGR00536 910348007346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348007347 S-adenosylmethionine binding site [chemical binding]; other site 910348007348 hypothetical protein; Provisional; Region: PRK04946 910348007349 Smr domain; Region: Smr; pfam01713 910348007350 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348007351 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 910348007352 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 910348007353 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 910348007354 Fimbrial protein; Region: Fimbrial; cl01416 910348007355 Fimbrial protein; Region: Fimbrial; cl01416 910348007356 Fimbrial protein; Region: Fimbrial; cl01416 910348007357 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 910348007358 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 910348007359 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 910348007360 PapC N-terminal domain; Region: PapC_N; pfam13954 910348007361 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 910348007362 PapC C-terminal domain; Region: PapC_C; pfam13953 910348007363 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 910348007364 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 910348007365 catalytic core [active] 910348007366 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 910348007367 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 910348007368 substrate binding site [chemical binding]; other site 910348007369 oxyanion hole (OAH) forming residues; other site 910348007370 trimer interface [polypeptide binding]; other site 910348007371 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 910348007372 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 910348007373 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 910348007374 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 910348007375 dimer interface [polypeptide binding]; other site 910348007376 active site 910348007377 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 910348007378 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 910348007379 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 910348007380 integrase; Provisional; Region: PRK09692 910348007381 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 910348007382 active site 910348007383 Int/Topo IB signature motif; other site 910348007384 Head binding; Region: Head_binding; pfam09008 910348007385 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 910348007386 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 910348007387 Phage anti-repressor protein [Transcription]; Region: COG3561 910348007388 Arc-like DNA binding domain; Region: Arc; pfam03869 910348007389 Mnt; Region: mnt; PHA01513 910348007390 Arc-like DNA binding domain; Region: Arc; pfam03869 910348007391 Regulatory protein Mnt; Region: Repressor_Mnt; pfam11423 910348007392 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 910348007393 P22 tail accessory factor; Region: P22_Tail-4; pfam11650 910348007394 coat protein; Region: PHA01511 910348007395 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 910348007396 Bacteriophage, scaffolding protein; Region: Phage-scaffold; pfam09306 910348007397 Terminase-like family; Region: Terminase_6; pfam03237 910348007398 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 910348007399 hypothetical protein; Region: PHA01971 910348007400 KilA-N domain; Region: KilA-N; pfam04383 910348007401 ORF11CD3 domain; Region: ORF11CD3; pfam10549 910348007402 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 910348007403 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 910348007404 N-acetyl-D-glucosamine binding site [chemical binding]; other site 910348007405 catalytic residue [active] 910348007406 phage holin, lambda family; Region: holin_lambda; TIGR01594 910348007407 Antitermination protein; Region: Antiterm; pfam03589 910348007408 Antitermination protein; Region: Antiterm; pfam03589 910348007409 Endodeoxyribonuclease RusA; Region: RusA; cl01885 910348007410 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 910348007411 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 910348007412 NinB protein; Region: NinB; pfam05772 910348007413 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 910348007414 phage replicative helicase, DnaB family, HK022 subfamily; Region: phage_DnaB; TIGR03600 910348007415 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 910348007416 Walker A motif; other site 910348007417 ATP binding site [chemical binding]; other site 910348007418 Walker B motif; other site 910348007419 Bacteriophage CII protein; Region: Phage_CII; pfam05269 910348007420 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 910348007421 salt bridge; other site 910348007422 non-specific DNA binding site [nucleotide binding]; other site 910348007423 sequence-specific DNA binding site [nucleotide binding]; other site 910348007424 Predicted transcriptional regulator [Transcription]; Region: COG2932 910348007425 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 910348007426 Catalytic site [active] 910348007427 cIII protein family; Region: cIII; pfam08134 910348007428 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 910348007429 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 910348007430 RecT family; Region: RecT; cl04285 910348007431 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 910348007432 Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) [Translation, ribosomal structure and biogenesis]; Region: Pnp; COG1185 910348007433 Protein of unknown function (DUF551); Region: DUF551; pfam04448 910348007434 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 910348007435 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 910348007436 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348007437 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 910348007438 dimerization interface [polypeptide binding]; other site 910348007439 substrate binding pocket [chemical binding]; other site 910348007440 permease DsdX; Provisional; Region: PRK09921 910348007441 gluconate transporter; Region: gntP; TIGR00791 910348007442 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 910348007443 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 910348007444 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 910348007445 catalytic residue [active] 910348007446 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 910348007447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348007448 putative substrate translocation pore; other site 910348007449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348007450 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 910348007451 HlyD family secretion protein; Region: HlyD_3; pfam13437 910348007452 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 910348007453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348007454 active site 910348007455 phosphorylation site [posttranslational modification] 910348007456 intermolecular recognition site; other site 910348007457 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 910348007458 DNA binding residues [nucleotide binding] 910348007459 dimerization interface [polypeptide binding]; other site 910348007460 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 910348007461 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 910348007462 substrate binding pocket [chemical binding]; other site 910348007463 membrane-bound complex binding site; other site 910348007464 hinge residues; other site 910348007465 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 910348007466 substrate binding pocket [chemical binding]; other site 910348007467 membrane-bound complex binding site; other site 910348007468 hinge residues; other site 910348007469 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 910348007470 dimer interface [polypeptide binding]; other site 910348007471 phosphorylation site [posttranslational modification] 910348007472 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348007473 ATP binding site [chemical binding]; other site 910348007474 Mg2+ binding site [ion binding]; other site 910348007475 G-X-G motif; other site 910348007476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348007477 active site 910348007478 phosphorylation site [posttranslational modification] 910348007479 intermolecular recognition site; other site 910348007480 dimerization interface [polypeptide binding]; other site 910348007481 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 910348007482 putative binding surface; other site 910348007483 active site 910348007484 putative CoA-transferase; Provisional; Region: PRK11430 910348007485 CoA-transferase family III; Region: CoA_transf_3; pfam02515 910348007486 putative transporter YfdV; Provisional; Region: PRK09903 910348007487 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 910348007488 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 910348007489 PYR/PP interface [polypeptide binding]; other site 910348007490 dimer interface [polypeptide binding]; other site 910348007491 TPP binding site [chemical binding]; other site 910348007492 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 910348007493 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 910348007494 TPP-binding site; other site 910348007495 dimer interface [polypeptide binding]; other site 910348007496 formyl-coenzyme A transferase; Provisional; Region: PRK05398 910348007497 CoA-transferase family III; Region: CoA_transf_3; pfam02515 910348007498 hypothetical protein; Provisional; Region: PRK10316 910348007499 YfdX protein; Region: YfdX; pfam10938 910348007500 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348007501 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 910348007502 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 910348007503 putative acyl-acceptor binding pocket; other site 910348007504 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348007505 aminotransferase; Validated; Region: PRK08175 910348007506 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 910348007507 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348007508 homodimer interface [polypeptide binding]; other site 910348007509 catalytic residue [active] 910348007510 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 910348007511 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 910348007512 GAF domain; Region: GAF; pfam01590 910348007513 Histidine kinase; Region: His_kinase; pfam06580 910348007514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348007515 ATP binding site [chemical binding]; other site 910348007516 Mg2+ binding site [ion binding]; other site 910348007517 G-X-G motif; other site 910348007518 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 910348007519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348007520 active site 910348007521 phosphorylation site [posttranslational modification] 910348007522 intermolecular recognition site; other site 910348007523 dimerization interface [polypeptide binding]; other site 910348007524 LytTr DNA-binding domain; Region: LytTR; pfam04397 910348007525 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 910348007526 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348007527 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 910348007528 dimerization domain swap beta strand [polypeptide binding]; other site 910348007529 regulatory protein interface [polypeptide binding]; other site 910348007530 active site 910348007531 regulatory phosphorylation site [posttranslational modification]; other site 910348007532 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 910348007533 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 910348007534 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 910348007535 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 910348007536 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 910348007537 active site 910348007538 phosphorylation site [posttranslational modification] 910348007539 exoaminopeptidase; Provisional; Region: PRK09961 910348007540 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 910348007541 oligomer interface [polypeptide binding]; other site 910348007542 active site 910348007543 metal binding site [ion binding]; metal-binding site 910348007544 aminopeptidase; Provisional; Region: PRK09795 910348007545 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 910348007546 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 910348007547 active site 910348007548 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 910348007549 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 910348007550 active site 910348007551 P-loop; other site 910348007552 phosphorylation site [posttranslational modification] 910348007553 glucokinase, proteobacterial type; Region: glk; TIGR00749 910348007554 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 910348007555 nucleotide binding site [chemical binding]; other site 910348007556 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 910348007557 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 910348007558 Cl- selectivity filter; other site 910348007559 Cl- binding residues [ion binding]; other site 910348007560 pore gating glutamate residue; other site 910348007561 dimer interface [polypeptide binding]; other site 910348007562 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 910348007563 manganese transport protein MntH; Reviewed; Region: PRK00701 910348007564 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 910348007565 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 910348007566 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 910348007567 Nucleoside recognition; Region: Gate; pfam07670 910348007568 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 910348007569 MASE1; Region: MASE1; pfam05231 910348007570 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 910348007571 diguanylate cyclase; Region: GGDEF; smart00267 910348007572 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 910348007573 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 910348007574 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 910348007575 salt bridge; other site 910348007576 non-specific DNA binding site [nucleotide binding]; other site 910348007577 sequence-specific DNA binding site [nucleotide binding]; other site 910348007578 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 910348007579 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 910348007580 active site 910348007581 HIGH motif; other site 910348007582 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 910348007583 active site 910348007584 KMSKS motif; other site 910348007585 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 910348007586 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348007587 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 910348007588 putative dimerization interface [polypeptide binding]; other site 910348007589 putative substrate binding pocket [chemical binding]; other site 910348007590 nucleoside transporter; Region: 2A0110; TIGR00889 910348007591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348007592 putative substrate translocation pore; other site 910348007593 purine nucleoside phosphorylase; Provisional; Region: PRK08202 910348007594 hypothetical protein; Provisional; Region: PRK11528 910348007595 Transcriptional regulator [Transcription]; Region: LysR; COG0583 910348007596 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348007597 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 910348007598 putative dimerization interface [polypeptide binding]; other site 910348007599 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 910348007600 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 910348007601 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 910348007602 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 910348007603 nucleotide binding pocket [chemical binding]; other site 910348007604 K-X-D-G motif; other site 910348007605 catalytic site [active] 910348007606 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 910348007607 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 910348007608 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 910348007609 Dimer interface [polypeptide binding]; other site 910348007610 BRCT sequence motif; other site 910348007611 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 910348007612 cell division protein ZipA; Provisional; Region: PRK03427 910348007613 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 910348007614 FtsZ protein binding site [polypeptide binding]; other site 910348007615 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 910348007616 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 910348007617 dimer interface [polypeptide binding]; other site 910348007618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348007619 catalytic residue [active] 910348007620 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 910348007621 dimerization domain swap beta strand [polypeptide binding]; other site 910348007622 regulatory protein interface [polypeptide binding]; other site 910348007623 active site 910348007624 regulatory phosphorylation site [posttranslational modification]; other site 910348007625 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 910348007626 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 910348007627 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 910348007628 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 910348007629 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 910348007630 HPr interaction site; other site 910348007631 glycerol kinase (GK) interaction site [polypeptide binding]; other site 910348007632 active site 910348007633 phosphorylation site [posttranslational modification] 910348007634 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 910348007635 dimer interface [polypeptide binding]; other site 910348007636 pyridoxamine kinase; Validated; Region: PRK05756 910348007637 pyridoxal binding site [chemical binding]; other site 910348007638 ATP binding site [chemical binding]; other site 910348007639 hypothetical protein; Provisional; Region: PRK10318 910348007640 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 910348007641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 910348007642 cysteine synthase B; Region: cysM; TIGR01138 910348007643 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 910348007644 dimer interface [polypeptide binding]; other site 910348007645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348007646 catalytic residue [active] 910348007647 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 910348007648 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 910348007649 Walker A/P-loop; other site 910348007650 ATP binding site [chemical binding]; other site 910348007651 Q-loop/lid; other site 910348007652 ABC transporter signature motif; other site 910348007653 Walker B; other site 910348007654 D-loop; other site 910348007655 H-loop/switch region; other site 910348007656 TOBE-like domain; Region: TOBE_3; pfam12857 910348007657 sulfate transport protein; Provisional; Region: cysT; CHL00187 910348007658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348007659 dimer interface [polypeptide binding]; other site 910348007660 conserved gate region; other site 910348007661 putative PBP binding loops; other site 910348007662 ABC-ATPase subunit interface; other site 910348007663 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 910348007664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348007665 dimer interface [polypeptide binding]; other site 910348007666 conserved gate region; other site 910348007667 putative PBP binding loops; other site 910348007668 ABC-ATPase subunit interface; other site 910348007669 thiosulfate transporter subunit; Provisional; Region: PRK10852 910348007670 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 910348007671 short chain dehydrogenase; Provisional; Region: PRK08226 910348007672 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 910348007673 NAD binding site [chemical binding]; other site 910348007674 homotetramer interface [polypeptide binding]; other site 910348007675 homodimer interface [polypeptide binding]; other site 910348007676 active site 910348007677 transcriptional regulator MurR; Provisional; Region: PRK15482 910348007678 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 910348007679 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 910348007680 putative active site [active] 910348007681 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 910348007682 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 910348007683 putative active site [active] 910348007684 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 910348007685 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 910348007686 active site turn [active] 910348007687 phosphorylation site [posttranslational modification] 910348007688 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 910348007689 putative periplasmic esterase; Provisional; Region: PRK03642 910348007690 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 910348007691 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 910348007692 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 910348007693 putative acetyltransferase; Provisional; Region: PRK03624 910348007694 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 910348007695 Coenzyme A binding pocket [chemical binding]; other site 910348007696 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 910348007697 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 910348007698 active site 910348007699 metal binding site [ion binding]; metal-binding site 910348007700 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 910348007701 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 910348007702 transcriptional regulator EutR; Provisional; Region: PRK10130 910348007703 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348007704 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348007705 carboxysome structural protein EutK; Provisional; Region: PRK15466 910348007706 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 910348007707 Hexamer interface [polypeptide binding]; other site 910348007708 Hexagonal pore residue; other site 910348007709 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 910348007710 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 910348007711 putative hexamer interface [polypeptide binding]; other site 910348007712 putative hexagonal pore; other site 910348007713 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 910348007714 putative hexamer interface [polypeptide binding]; other site 910348007715 putative hexagonal pore; other site 910348007716 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 910348007717 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 910348007718 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 910348007719 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 910348007720 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 910348007721 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 910348007722 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 910348007723 active site 910348007724 metal binding site [ion binding]; metal-binding site 910348007725 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 910348007726 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 910348007727 nucleotide binding site [chemical binding]; other site 910348007728 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 910348007729 putative catalytic cysteine [active] 910348007730 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 910348007731 Hexamer/Pentamer interface [polypeptide binding]; other site 910348007732 central pore; other site 910348007733 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 910348007734 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 910348007735 Hexamer interface [polypeptide binding]; other site 910348007736 Putative hexagonal pore residue; other site 910348007737 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 910348007738 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 910348007739 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 910348007740 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 910348007741 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 910348007742 G1 box; other site 910348007743 GTP/Mg2+ binding site [chemical binding]; other site 910348007744 G2 box; other site 910348007745 Switch I region; other site 910348007746 G3 box; other site 910348007747 Switch II region; other site 910348007748 G4 box; other site 910348007749 G5 box; other site 910348007750 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 910348007751 putative hexamer interface [polypeptide binding]; other site 910348007752 putative hexagonal pore; other site 910348007753 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 910348007754 Malic enzyme, N-terminal domain; Region: malic; pfam00390 910348007755 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 910348007756 putative NAD(P) binding site [chemical binding]; other site 910348007757 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 910348007758 transaldolase-like protein; Provisional; Region: PTZ00411 910348007759 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 910348007760 active site 910348007761 dimer interface [polypeptide binding]; other site 910348007762 catalytic residue [active] 910348007763 transketolase; Reviewed; Region: PRK12753 910348007764 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 910348007765 TPP-binding site [chemical binding]; other site 910348007766 dimer interface [polypeptide binding]; other site 910348007767 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 910348007768 PYR/PP interface [polypeptide binding]; other site 910348007769 dimer interface [polypeptide binding]; other site 910348007770 TPP binding site [chemical binding]; other site 910348007771 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 910348007772 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 910348007773 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 910348007774 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 910348007775 dimer interface [polypeptide binding]; other site 910348007776 ADP-ribose binding site [chemical binding]; other site 910348007777 active site 910348007778 nudix motif; other site 910348007779 metal binding site [ion binding]; metal-binding site 910348007780 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 910348007781 4Fe-4S binding domain; Region: Fer4; pfam00037 910348007782 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 910348007783 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 910348007784 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 910348007785 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 910348007786 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 910348007787 dimerization interface [polypeptide binding]; other site 910348007788 Histidine kinase; Region: HisKA_3; pfam07730 910348007789 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348007790 ATP binding site [chemical binding]; other site 910348007791 Mg2+ binding site [ion binding]; other site 910348007792 G-X-G motif; other site 910348007793 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 910348007794 Protein export membrane protein; Region: SecD_SecF; cl14618 910348007795 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 910348007796 ArsC family; Region: ArsC; pfam03960 910348007797 putative catalytic residues [active] 910348007798 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 910348007799 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 910348007800 metal binding site [ion binding]; metal-binding site 910348007801 dimer interface [polypeptide binding]; other site 910348007802 putative hydrolase; Provisional; Region: PRK11460 910348007803 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 910348007804 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 910348007805 Helicase; Region: Helicase_RecD; pfam05127 910348007806 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 910348007807 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 910348007808 Predicted metalloprotease [General function prediction only]; Region: COG2321 910348007809 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 910348007810 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 910348007811 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 910348007812 ATP binding site [chemical binding]; other site 910348007813 active site 910348007814 substrate binding site [chemical binding]; other site 910348007815 lipoprotein; Provisional; Region: PRK11679 910348007816 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 910348007817 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 910348007818 dihydrodipicolinate synthase; Region: dapA; TIGR00674 910348007819 dimer interface [polypeptide binding]; other site 910348007820 active site 910348007821 catalytic residue [active] 910348007822 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 910348007823 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 910348007824 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 910348007825 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 910348007826 catalytic triad [active] 910348007827 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 910348007828 4Fe-4S binding domain; Region: Fer4; pfam00037 910348007829 hydrogenase 4 subunit B; Validated; Region: PRK06521 910348007830 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 910348007831 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 910348007832 NADH dehydrogenase; Region: NADHdh; cl00469 910348007833 hydrogenase 4 subunit D; Validated; Region: PRK06525 910348007834 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 910348007835 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 910348007836 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 910348007837 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 910348007838 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 910348007839 hydrogenase 4 subunit H; Validated; Region: PRK08222 910348007840 4Fe-4S binding domain; Region: Fer4; pfam00037 910348007841 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 910348007842 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 910348007843 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 910348007844 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 910348007845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348007846 Walker A motif; other site 910348007847 ATP binding site [chemical binding]; other site 910348007848 Walker B motif; other site 910348007849 arginine finger; other site 910348007850 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 910348007851 putative formate transporter; Provisional; Region: focB; PRK09713 910348007852 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 910348007853 Domain of unknown function DUF20; Region: UPF0118; pfam01594 910348007854 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 910348007855 Peptidase family M48; Region: Peptidase_M48; cl12018 910348007856 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 910348007857 ArsC family; Region: ArsC; pfam03960 910348007858 catalytic residues [active] 910348007859 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 910348007860 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 910348007861 uracil transporter; Provisional; Region: PRK10720 910348007862 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 910348007863 active site 910348007864 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 910348007865 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 910348007866 dimerization interface [polypeptide binding]; other site 910348007867 putative ATP binding site [chemical binding]; other site 910348007868 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 910348007869 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 910348007870 active site 910348007871 substrate binding site [chemical binding]; other site 910348007872 cosubstrate binding site; other site 910348007873 catalytic site [active] 910348007874 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 910348007875 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 910348007876 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 910348007877 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 910348007878 domain interface [polypeptide binding]; other site 910348007879 active site 910348007880 catalytic site [active] 910348007881 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 910348007882 putative active site [active] 910348007883 catalytic site [active] 910348007884 exopolyphosphatase; Provisional; Region: PRK10854 910348007885 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 910348007886 MASE1; Region: MASE1; pfam05231 910348007887 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 910348007888 diguanylate cyclase; Region: GGDEF; smart00267 910348007889 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 910348007890 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 910348007891 GMP synthase; Reviewed; Region: guaA; PRK00074 910348007892 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 910348007893 AMP/PPi binding site [chemical binding]; other site 910348007894 candidate oxyanion hole; other site 910348007895 catalytic triad [active] 910348007896 potential glutamine specificity residues [chemical binding]; other site 910348007897 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 910348007898 ATP Binding subdomain [chemical binding]; other site 910348007899 Ligand Binding sites [chemical binding]; other site 910348007900 Dimerization subdomain; other site 910348007901 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 910348007902 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 910348007903 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 910348007904 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 910348007905 active site 910348007906 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 910348007907 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 910348007908 generic binding surface II; other site 910348007909 generic binding surface I; other site 910348007910 GTP-binding protein Der; Reviewed; Region: PRK00093 910348007911 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 910348007912 G1 box; other site 910348007913 GTP/Mg2+ binding site [chemical binding]; other site 910348007914 Switch I region; other site 910348007915 G2 box; other site 910348007916 Switch II region; other site 910348007917 G3 box; other site 910348007918 G4 box; other site 910348007919 G5 box; other site 910348007920 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 910348007921 G1 box; other site 910348007922 GTP/Mg2+ binding site [chemical binding]; other site 910348007923 Switch I region; other site 910348007924 G2 box; other site 910348007925 G3 box; other site 910348007926 Switch II region; other site 910348007927 G4 box; other site 910348007928 G5 box; other site 910348007929 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 910348007930 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 910348007931 Trp docking motif [polypeptide binding]; other site 910348007932 active site 910348007933 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 910348007934 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 910348007935 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 910348007936 dimer interface [polypeptide binding]; other site 910348007937 motif 1; other site 910348007938 active site 910348007939 motif 2; other site 910348007940 motif 3; other site 910348007941 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 910348007942 anticodon binding site; other site 910348007943 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 910348007944 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 910348007945 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 910348007946 cytoskeletal protein RodZ; Provisional; Region: PRK10856 910348007947 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 910348007948 non-specific DNA binding site [nucleotide binding]; other site 910348007949 salt bridge; other site 910348007950 sequence-specific DNA binding site [nucleotide binding]; other site 910348007951 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 910348007952 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 910348007953 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 910348007954 FeS/SAM binding site; other site 910348007955 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 910348007956 active site 910348007957 multimer interface [polypeptide binding]; other site 910348007958 penicillin-binding protein 1C; Provisional; Region: PRK11240 910348007959 Transglycosylase; Region: Transgly; pfam00912 910348007960 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 910348007961 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 910348007962 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 910348007963 MG2 domain; Region: A2M_N; pfam01835 910348007964 Alpha-2-macroglobulin family; Region: A2M; pfam00207 910348007965 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 910348007966 surface patch; other site 910348007967 thioester region; other site 910348007968 specificity defining residues; other site 910348007969 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 910348007970 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 910348007971 active site residue [active] 910348007972 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 910348007973 active site residue [active] 910348007974 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 910348007975 aminopeptidase B; Provisional; Region: PRK05015 910348007976 Peptidase; Region: DUF3663; pfam12404 910348007977 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 910348007978 interface (dimer of trimers) [polypeptide binding]; other site 910348007979 Substrate-binding/catalytic site; other site 910348007980 Zn-binding sites [ion binding]; other site 910348007981 hypothetical protein; Provisional; Region: PRK10721 910348007982 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 910348007983 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 910348007984 catalytic loop [active] 910348007985 iron binding site [ion binding]; other site 910348007986 chaperone protein HscA; Provisional; Region: hscA; PRK05183 910348007987 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 910348007988 nucleotide binding site [chemical binding]; other site 910348007989 putative NEF/HSP70 interaction site [polypeptide binding]; other site 910348007990 SBD interface [polypeptide binding]; other site 910348007991 co-chaperone HscB; Provisional; Region: hscB; PRK05014 910348007992 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 910348007993 HSP70 interaction site [polypeptide binding]; other site 910348007994 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 910348007995 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 910348007996 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 910348007997 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 910348007998 trimerization site [polypeptide binding]; other site 910348007999 active site 910348008000 cysteine desulfurase; Provisional; Region: PRK14012 910348008001 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 910348008002 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 910348008003 catalytic residue [active] 910348008004 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 910348008005 Rrf2 family protein; Region: rrf2_super; TIGR00738 910348008006 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 910348008007 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 910348008008 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 910348008009 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 910348008010 active site 910348008011 dimerization interface [polypeptide binding]; other site 910348008012 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 910348008013 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 910348008014 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 910348008015 PRD domain; Region: PRD; pfam00874 910348008016 PRD domain; Region: PRD; pfam00874 910348008017 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 910348008018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348008019 putative substrate translocation pore; other site 910348008020 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 910348008021 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348008022 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 910348008023 dimerization interface [polypeptide binding]; other site 910348008024 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 910348008025 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 910348008026 iron-sulfur cluster [ion binding]; other site 910348008027 [2Fe-2S] cluster binding site [ion binding]; other site 910348008028 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 910348008029 beta subunit interface [polypeptide binding]; other site 910348008030 alpha subunit interface [polypeptide binding]; other site 910348008031 active site 910348008032 substrate binding site [chemical binding]; other site 910348008033 Fe binding site [ion binding]; other site 910348008034 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 910348008035 inter-subunit interface; other site 910348008036 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 910348008037 [2Fe-2S] cluster binding site [ion binding]; other site 910348008038 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 910348008039 cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348 910348008040 NAD binding site [chemical binding]; other site 910348008041 active site 910348008042 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 910348008043 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 910348008044 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348008045 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 910348008046 active site 910348008047 catalytic residues [active] 910348008048 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 910348008049 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 910348008050 putative NAD(P) binding site [chemical binding]; other site 910348008051 catalytic Zn binding site [ion binding]; other site 910348008052 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 910348008053 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 910348008054 TM-ABC transporter signature motif; other site 910348008055 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 910348008056 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 910348008057 Walker A/P-loop; other site 910348008058 ATP binding site [chemical binding]; other site 910348008059 Q-loop/lid; other site 910348008060 ABC transporter signature motif; other site 910348008061 Walker B; other site 910348008062 D-loop; other site 910348008063 H-loop/switch region; other site 910348008064 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 910348008065 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 910348008066 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 910348008067 ligand binding site [chemical binding]; other site 910348008068 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 910348008069 TPR motif; other site 910348008070 Tetratricopeptide repeat; Region: TPR_16; pfam13432 910348008071 binding surface 910348008072 TPR repeat; Region: TPR_11; pfam13414 910348008073 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 910348008074 TPR motif; other site 910348008075 binding surface 910348008076 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 910348008077 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 910348008078 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 910348008079 nucleotide binding site [chemical binding]; other site 910348008080 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 910348008081 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 910348008082 heme-binding site [chemical binding]; other site 910348008083 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 910348008084 FAD binding pocket [chemical binding]; other site 910348008085 FAD binding motif [chemical binding]; other site 910348008086 phosphate binding motif [ion binding]; other site 910348008087 beta-alpha-beta structure motif; other site 910348008088 NAD binding pocket [chemical binding]; other site 910348008089 Heme binding pocket [chemical binding]; other site 910348008090 response regulator GlrR; Provisional; Region: PRK15115 910348008091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348008092 active site 910348008093 phosphorylation site [posttranslational modification] 910348008094 intermolecular recognition site; other site 910348008095 dimerization interface [polypeptide binding]; other site 910348008096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348008097 Walker A motif; other site 910348008098 ATP binding site [chemical binding]; other site 910348008099 Walker B motif; other site 910348008100 arginine finger; other site 910348008101 hypothetical protein; Provisional; Region: PRK10722 910348008102 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 910348008103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 910348008104 dimer interface [polypeptide binding]; other site 910348008105 phosphorylation site [posttranslational modification] 910348008106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348008107 ATP binding site [chemical binding]; other site 910348008108 Mg2+ binding site [ion binding]; other site 910348008109 G-X-G motif; other site 910348008110 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 910348008111 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 910348008112 dimerization interface [polypeptide binding]; other site 910348008113 ATP binding site [chemical binding]; other site 910348008114 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 910348008115 dimerization interface [polypeptide binding]; other site 910348008116 ATP binding site [chemical binding]; other site 910348008117 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 910348008118 putative active site [active] 910348008119 catalytic triad [active] 910348008120 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 910348008121 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 910348008122 substrate binding pocket [chemical binding]; other site 910348008123 membrane-bound complex binding site; other site 910348008124 hinge residues; other site 910348008125 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 910348008126 N-acetyl-D-glucosamine binding site [chemical binding]; other site 910348008127 catalytic residue [active] 910348008128 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 910348008129 nucleoside/Zn binding site; other site 910348008130 dimer interface [polypeptide binding]; other site 910348008131 catalytic motif [active] 910348008132 hypothetical protein; Provisional; Region: PRK11590 910348008133 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 910348008134 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 910348008135 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 910348008136 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 910348008137 putative active site [active] 910348008138 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 910348008139 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 910348008140 active site 910348008141 hydrophilic channel; other site 910348008142 dimerization interface [polypeptide binding]; other site 910348008143 catalytic residues [active] 910348008144 active site lid [active] 910348008145 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 910348008146 Recombination protein O N terminal; Region: RecO_N; pfam11967 910348008147 Recombination protein O C terminal; Region: RecO_C; pfam02565 910348008148 GTPase Era; Reviewed; Region: era; PRK00089 910348008149 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 910348008150 G1 box; other site 910348008151 GTP/Mg2+ binding site [chemical binding]; other site 910348008152 Switch I region; other site 910348008153 G2 box; other site 910348008154 Switch II region; other site 910348008155 G3 box; other site 910348008156 G4 box; other site 910348008157 G5 box; other site 910348008158 KH domain; Region: KH_2; pfam07650 910348008159 ribonuclease III; Reviewed; Region: rnc; PRK00102 910348008160 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 910348008161 metal binding site [ion binding]; metal-binding site 910348008162 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 910348008163 dsRNA binding site [nucleotide binding]; other site 910348008164 signal peptidase I; Provisional; Region: PRK10861 910348008165 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 910348008166 Catalytic site [active] 910348008167 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 910348008168 GTP-binding protein LepA; Provisional; Region: PRK05433 910348008169 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 910348008170 G1 box; other site 910348008171 putative GEF interaction site [polypeptide binding]; other site 910348008172 GTP/Mg2+ binding site [chemical binding]; other site 910348008173 Switch I region; other site 910348008174 G2 box; other site 910348008175 G3 box; other site 910348008176 Switch II region; other site 910348008177 G4 box; other site 910348008178 G5 box; other site 910348008179 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 910348008180 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 910348008181 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 910348008182 SoxR reducing system protein RseC; Provisional; Region: PRK10862 910348008183 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 910348008184 anti-sigma E factor; Provisional; Region: rseB; PRK09455 910348008185 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 910348008186 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 910348008187 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 910348008188 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 910348008189 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 910348008190 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 910348008191 DNA binding residues [nucleotide binding] 910348008192 L-aspartate oxidase; Provisional; Region: PRK09077 910348008193 L-aspartate oxidase; Provisional; Region: PRK06175 910348008194 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 910348008195 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 910348008196 Methyltransferase domain; Region: Methyltransf_26; pfam13659 910348008197 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 910348008198 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 910348008199 ATP binding site [chemical binding]; other site 910348008200 Mg++ binding site [ion binding]; other site 910348008201 motif III; other site 910348008202 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 910348008203 nucleotide binding region [chemical binding]; other site 910348008204 ATP-binding site [chemical binding]; other site 910348008205 Transcriptional regulator [Transcription]; Region: LysR; COG0583 910348008206 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348008207 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 910348008208 dimerization interface [polypeptide binding]; other site 910348008209 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 910348008210 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 910348008211 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 910348008212 ligand binding site [chemical binding]; other site 910348008213 active site 910348008214 UGI interface [polypeptide binding]; other site 910348008215 catalytic site [active] 910348008216 putative methyltransferase; Provisional; Region: PRK10864 910348008217 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 910348008218 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 910348008219 thioredoxin 2; Provisional; Region: PRK10996 910348008220 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 910348008221 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 910348008222 catalytic residues [active] 910348008223 Uncharacterized conserved protein [Function unknown]; Region: COG3148 910348008224 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 910348008225 CoA binding domain; Region: CoA_binding_2; pfam13380 910348008226 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 910348008227 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 910348008228 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 910348008229 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 910348008230 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 910348008231 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 910348008232 domain interface [polypeptide binding]; other site 910348008233 putative active site [active] 910348008234 catalytic site [active] 910348008235 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 910348008236 domain interface [polypeptide binding]; other site 910348008237 putative active site [active] 910348008238 catalytic site [active] 910348008239 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 910348008240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348008241 putative substrate translocation pore; other site 910348008242 protein disaggregation chaperone; Provisional; Region: PRK10865 910348008243 Clp amino terminal domain; Region: Clp_N; pfam02861 910348008244 Clp amino terminal domain; Region: Clp_N; pfam02861 910348008245 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348008246 Walker A motif; other site 910348008247 ATP binding site [chemical binding]; other site 910348008248 Walker B motif; other site 910348008249 arginine finger; other site 910348008250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348008251 Walker A motif; other site 910348008252 ATP binding site [chemical binding]; other site 910348008253 Walker B motif; other site 910348008254 arginine finger; other site 910348008255 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 910348008256 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 910348008257 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 910348008258 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 910348008259 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 910348008260 RNA binding surface [nucleotide binding]; other site 910348008261 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 910348008262 active site 910348008263 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 910348008264 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 910348008265 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 910348008266 30S subunit binding site; other site 910348008267 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 910348008268 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 910348008269 Prephenate dehydratase; Region: PDT; pfam00800 910348008270 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 910348008271 putative L-Phe binding site [chemical binding]; other site 910348008272 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 910348008273 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 910348008274 prephenate dehydrogenase; Validated; Region: PRK08507 910348008275 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 910348008276 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 910348008277 lipoprotein; Provisional; Region: PRK11443 910348008278 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 910348008279 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 910348008280 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 910348008281 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 910348008282 metal binding site [ion binding]; metal-binding site 910348008283 active site 910348008284 I-site; other site 910348008285 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 910348008286 ligand binding site [chemical binding]; other site 910348008287 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 910348008288 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 910348008289 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 910348008290 RimM N-terminal domain; Region: RimM; pfam01782 910348008291 PRC-barrel domain; Region: PRC; pfam05239 910348008292 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 910348008293 signal recognition particle protein; Provisional; Region: PRK10867 910348008294 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 910348008295 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 910348008296 P loop; other site 910348008297 GTP binding site [chemical binding]; other site 910348008298 Signal peptide binding domain; Region: SRP_SPB; pfam02978 910348008299 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 910348008300 potential frameshift: common BLAST hit: gi|145698304|ref|YP_026171.3| inner membrane protein, UPF0053 family 910348008301 Domain of unknown function DUF21; Region: DUF21; pfam01595 910348008302 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 910348008303 Transporter associated domain; Region: CorC_HlyC; smart01091 910348008304 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 910348008305 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 910348008306 dimer interface [polypeptide binding]; other site 910348008307 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 910348008308 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 910348008309 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 910348008310 recombination and repair protein; Provisional; Region: PRK10869 910348008311 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 910348008312 Walker A/P-loop; other site 910348008313 ATP binding site [chemical binding]; other site 910348008314 Q-loop/lid; other site 910348008315 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 910348008316 Q-loop/lid; other site 910348008317 ABC transporter signature motif; other site 910348008318 Walker B; other site 910348008319 D-loop; other site 910348008320 H-loop/switch region; other site 910348008321 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 910348008322 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 910348008323 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 910348008324 putative coenzyme Q binding site [chemical binding]; other site 910348008325 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 910348008326 SmpB-tmRNA interface; other site 910348008327 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 910348008328 tail protein; Provisional; Region: D; PHA02561 910348008329 Phage protein U [General function prediction only]; Region: COG3499 910348008330 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 910348008331 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 910348008332 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 910348008333 major tail tube protein; Provisional; Region: FII; PHA02600 910348008334 major tail sheath protein; Provisional; Region: FI; PHA02560 910348008335 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 910348008336 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 910348008337 catalytic residues [active] 910348008338 catalytic nucleophile [active] 910348008339 Presynaptic Site I dimer interface [polypeptide binding]; other site 910348008340 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 910348008341 Synaptic Flat tetramer interface [polypeptide binding]; other site 910348008342 Synaptic Site I dimer interface [polypeptide binding]; other site 910348008343 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 910348008344 DNA-binding interface [nucleotide binding]; DNA binding site 910348008345 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 910348008346 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 910348008347 Phage Tail Collar Domain; Region: Collar; pfam07484 910348008348 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 910348008349 baseplate assembly protein; Provisional; Region: J; PHA02568 910348008350 baseplate wedge subunit; Provisional; Region: W; PHA02516 910348008351 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 910348008352 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 910348008353 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 910348008354 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 910348008355 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 910348008356 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 910348008357 catalytic residues [active] 910348008358 P2-like prophage tail protein X [General function prediction only]; Region: COG5004 910348008359 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 910348008360 terminase endonuclease subunit; Provisional; Region: M; PHA02537 910348008361 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 910348008362 capsid protein; Provisional; Region: N; PHA02538 910348008363 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929 910348008364 terminase ATPase subunit; Provisional; Region: P; PHA02535 910348008365 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 910348008366 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 910348008367 DinI-like family; Region: DinI; pfam06183 910348008368 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 910348008369 Herpesvirus large structural phosphoprotein UL32; Region: Herpes_UL32; pfam06070 910348008370 DNA adenine methylase (dam); Region: dam; TIGR00571 910348008371 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 910348008372 Predicted transcriptional regulator [Transcription]; Region: COG2932 910348008373 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 910348008374 integrase; Provisional; Region: int; PHA02601 910348008375 Leucine carboxyl methyltransferase; Region: LCM; cl01306 910348008376 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 910348008377 active site 910348008378 DNA binding site [nucleotide binding] 910348008379 Int/Topo IB signature motif; other site 910348008380 integrase; Provisional; Region: PRK09692 910348008381 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 910348008382 active site 910348008383 Int/Topo IB signature motif; other site 910348008384 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 910348008385 Walker A/P-loop; other site 910348008386 ATP binding site [chemical binding]; other site 910348008387 Protein of unknown function (DUF3732); Region: DUF3732; pfam12532 910348008388 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 910348008389 His-Xaa-Ser system radical SAM maturase HxsC; Region: rSAM_pair_HxsC; TIGR03977 910348008390 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 910348008391 FeS/SAM binding site; other site 910348008392 His-Xaa-Ser system radical SAM maturase HxsB; Region: rSAM_paired_1; TIGR03978 910348008393 Transposase; Region: HTH_Tnp_1; cl17663 910348008394 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 910348008395 putative transposase OrfB; Reviewed; Region: PHA02517 910348008396 HTH-like domain; Region: HTH_21; pfam13276 910348008397 Integrase core domain; Region: rve; pfam00665 910348008398 Integrase core domain; Region: rve_2; pfam13333 910348008399 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 910348008400 active site 910348008401 catalytic site [active] 910348008402 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 910348008403 substrate binding pocket [chemical binding]; other site 910348008404 active site 910348008405 iron coordination sites [ion binding]; other site 910348008406 Predicted dehydrogenase [General function prediction only]; Region: COG0579 910348008407 hydroxyglutarate oxidase; Provisional; Region: PRK11728 910348008408 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 910348008409 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 910348008410 tetramerization interface [polypeptide binding]; other site 910348008411 NAD(P) binding site [chemical binding]; other site 910348008412 catalytic residues [active] 910348008413 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 910348008414 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 910348008415 inhibitor-cofactor binding pocket; inhibition site 910348008416 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348008417 catalytic residue [active] 910348008418 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 910348008419 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 910348008420 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 910348008421 DNA-binding site [nucleotide binding]; DNA binding site 910348008422 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 910348008423 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 910348008424 bacterial OsmY and nodulation domain; Region: BON; smart00749 910348008425 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 910348008426 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 910348008427 dimerization interface [polypeptide binding]; other site 910348008428 putative DNA binding site [nucleotide binding]; other site 910348008429 Transcriptional regulators [Transcription]; Region: MarR; COG1846 910348008430 putative Zn2+ binding site [ion binding]; other site 910348008431 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 910348008432 active site residue [active] 910348008433 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 910348008434 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 910348008435 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 910348008436 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 910348008437 hypothetical protein; Provisional; Region: PRK10556 910348008438 hypothetical protein; Provisional; Region: PRK10132 910348008439 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 910348008440 catalytic residues [active] 910348008441 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 910348008442 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 910348008443 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 910348008444 Class I ribonucleotide reductase; Region: RNR_I; cd01679 910348008445 active site 910348008446 dimer interface [polypeptide binding]; other site 910348008447 catalytic residues [active] 910348008448 effector binding site; other site 910348008449 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 910348008450 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 910348008451 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 910348008452 Walker A/P-loop; other site 910348008453 ATP binding site [chemical binding]; other site 910348008454 Q-loop/lid; other site 910348008455 ABC transporter signature motif; other site 910348008456 Walker B; other site 910348008457 D-loop; other site 910348008458 H-loop/switch region; other site 910348008459 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 910348008460 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 910348008461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348008462 dimer interface [polypeptide binding]; other site 910348008463 conserved gate region; other site 910348008464 putative PBP binding loops; other site 910348008465 ABC-ATPase subunit interface; other site 910348008466 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 910348008467 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 910348008468 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 910348008469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348008470 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 910348008471 putative L-valine exporter; Provisional; Region: PRK10408 910348008472 transcriptional repressor MprA; Provisional; Region: PRK10870 910348008473 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 910348008474 HlyD family secretion protein; Region: HlyD; pfam00529 910348008475 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 910348008476 HlyD family secretion protein; Region: HlyD_3; pfam13437 910348008477 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 910348008478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348008479 putative substrate translocation pore; other site 910348008480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348008481 S-ribosylhomocysteinase; Provisional; Region: PRK02260 910348008482 glutamate--cysteine ligase; Provisional; Region: PRK02107 910348008483 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 910348008484 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 910348008485 motif II; other site 910348008486 carbon storage regulator; Provisional; Region: PRK01712 910348008487 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 910348008488 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 910348008489 active site 910348008490 motif 2; other site 910348008491 motif 3; other site 910348008492 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 910348008493 DHHA1 domain; Region: DHHA1; pfam02272 910348008494 recombination regulator RecX; Reviewed; Region: recX; PRK00117 910348008495 recombinase A; Provisional; Region: recA; PRK09354 910348008496 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 910348008497 hexamer interface [polypeptide binding]; other site 910348008498 Walker A motif; other site 910348008499 ATP binding site [chemical binding]; other site 910348008500 Walker B motif; other site 910348008501 hypothetical protein; Validated; Region: PRK03661 910348008502 Transglycosylase SLT domain; Region: SLT_2; pfam13406 910348008503 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 910348008504 N-acetyl-D-glucosamine binding site [chemical binding]; other site 910348008505 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 910348008506 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 910348008507 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 910348008508 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 910348008509 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 910348008510 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 910348008511 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 910348008512 putative NAD(P) binding site [chemical binding]; other site 910348008513 active site 910348008514 Glucitol operon activator protein (GutM); Region: GutM; cl01890 910348008515 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 910348008516 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 910348008517 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 910348008518 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 910348008519 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 910348008520 putative active site [active] 910348008521 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 910348008522 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 910348008523 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 910348008524 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348008525 Walker A motif; other site 910348008526 ATP binding site [chemical binding]; other site 910348008527 Walker B motif; other site 910348008528 arginine finger; other site 910348008529 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 910348008530 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 910348008531 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 910348008532 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 910348008533 iron binding site [ion binding]; other site 910348008534 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 910348008535 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 910348008536 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 910348008537 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 910348008538 Acylphosphatase; Region: Acylphosphatase; pfam00708 910348008539 HypF finger; Region: zf-HYPF; pfam07503 910348008540 HypF finger; Region: zf-HYPF; pfam07503 910348008541 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 910348008542 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 910348008543 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 910348008544 Transcriptional regulators [Transcription]; Region: PurR; COG1609 910348008545 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 910348008546 DNA binding site [nucleotide binding] 910348008547 domain linker motif; other site 910348008548 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 910348008549 dimerization interface (closed form) [polypeptide binding]; other site 910348008550 ligand binding site [chemical binding]; other site 910348008551 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 910348008552 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 910348008553 active site turn [active] 910348008554 phosphorylation site [posttranslational modification] 910348008555 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 910348008556 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 910348008557 beta-galactosidase; Region: BGL; TIGR03356 910348008558 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 910348008559 nickel binding site [ion binding]; other site 910348008560 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 910348008561 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 910348008562 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 910348008563 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 910348008564 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 910348008565 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 910348008566 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 910348008567 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 910348008568 NADH dehydrogenase; Region: NADHdh; cl00469 910348008569 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 910348008570 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 910348008571 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 910348008572 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 910348008573 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 910348008574 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 910348008575 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 910348008576 hydrogenase assembly chaperone; Provisional; Region: PRK10409 910348008577 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 910348008578 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 910348008579 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 910348008580 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 910348008581 dimerization interface [polypeptide binding]; other site 910348008582 ATP binding site [chemical binding]; other site 910348008583 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 910348008584 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 910348008585 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 910348008586 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348008587 Walker A motif; other site 910348008588 ATP binding site [chemical binding]; other site 910348008589 Walker B motif; other site 910348008590 arginine finger; other site 910348008591 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 910348008592 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 910348008593 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 910348008594 MutS domain I; Region: MutS_I; pfam01624 910348008595 MutS domain II; Region: MutS_II; pfam05188 910348008596 MutS domain III; Region: MutS_III; pfam05192 910348008597 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 910348008598 Walker A/P-loop; other site 910348008599 ATP binding site [chemical binding]; other site 910348008600 Q-loop/lid; other site 910348008601 ABC transporter signature motif; other site 910348008602 Walker B; other site 910348008603 D-loop; other site 910348008604 H-loop/switch region; other site 910348008605 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 910348008606 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 910348008607 active site 910348008608 metal binding site [ion binding]; metal-binding site 910348008609 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 910348008610 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 910348008611 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 910348008612 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 910348008613 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 910348008614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 910348008615 putative aldolase; Validated; Region: PRK08130 910348008616 active site 910348008617 intersubunit interface [polypeptide binding]; other site 910348008618 Zn2+ binding site [ion binding]; other site 910348008619 hypothetical protein; Provisional; Region: PRK09989 910348008620 putative transporter; Provisional; Region: PRK09821 910348008621 GntP family permease; Region: GntP_permease; pfam02447 910348008622 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 910348008623 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 910348008624 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 910348008625 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 910348008626 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 910348008627 DNA binding residues [nucleotide binding] 910348008628 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 910348008629 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 910348008630 Peptidase family M23; Region: Peptidase_M23; pfam01551 910348008631 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 910348008632 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348008633 S-adenosylmethionine binding site [chemical binding]; other site 910348008634 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 910348008635 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 910348008636 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 910348008637 Permutation of conserved domain; other site 910348008638 active site 910348008639 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 910348008640 homotrimer interaction site [polypeptide binding]; other site 910348008641 zinc binding site [ion binding]; other site 910348008642 CDP-binding sites; other site 910348008643 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 910348008644 substrate binding site; other site 910348008645 dimer interface; other site 910348008646 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 910348008647 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 910348008648 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 910348008649 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 910348008650 ligand-binding site [chemical binding]; other site 910348008651 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 910348008652 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 910348008653 CysD dimerization site [polypeptide binding]; other site 910348008654 G1 box; other site 910348008655 putative GEF interaction site [polypeptide binding]; other site 910348008656 GTP/Mg2+ binding site [chemical binding]; other site 910348008657 Switch I region; other site 910348008658 G2 box; other site 910348008659 G3 box; other site 910348008660 Switch II region; other site 910348008661 G4 box; other site 910348008662 G5 box; other site 910348008663 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 910348008664 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 910348008665 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 910348008666 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 910348008667 Active Sites [active] 910348008668 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 910348008669 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 910348008670 metal binding site [ion binding]; metal-binding site 910348008671 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 910348008672 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 910348008673 Hok/gef family; Region: HOK_GEF; pfam01848 910348008674 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 910348008675 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 910348008676 Active Sites [active] 910348008677 sulfite reductase subunit beta; Provisional; Region: PRK13504 910348008678 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 910348008679 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 910348008680 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 910348008681 Flavodoxin; Region: Flavodoxin_1; pfam00258 910348008682 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 910348008683 FAD binding pocket [chemical binding]; other site 910348008684 FAD binding motif [chemical binding]; other site 910348008685 catalytic residues [active] 910348008686 NAD binding pocket [chemical binding]; other site 910348008687 phosphate binding motif [ion binding]; other site 910348008688 beta-alpha-beta structure motif; other site 910348008689 6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470 910348008690 homohexamer interface [polypeptide binding]; other site 910348008691 putative substrate stabilizing pore; other site 910348008692 pterin binding site; other site 910348008693 FAD dependent oxidoreductase; Region: DAO; pfam01266 910348008694 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 910348008695 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 910348008696 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 910348008697 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 910348008698 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 910348008699 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 910348008700 Ligand binding site [chemical binding]; other site 910348008701 Electron transfer flavoprotein domain; Region: ETF; pfam01012 910348008702 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 910348008703 benzoate transport; Region: 2A0115; TIGR00895 910348008704 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348008705 putative substrate translocation pore; other site 910348008706 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 910348008707 FAD binding domain; Region: FAD_binding_4; pfam01565 910348008708 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 910348008709 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 910348008710 NADP binding site [chemical binding]; other site 910348008711 homodimer interface [polypeptide binding]; other site 910348008712 active site 910348008713 Major Facilitator Superfamily; Region: MFS_1; pfam07690 910348008714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348008715 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 910348008716 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 910348008717 nucleotide binding site [chemical binding]; other site 910348008718 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 910348008719 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 910348008720 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 910348008721 Repair protein; Region: Repair_PSII; pfam04536 910348008722 enolase; Provisional; Region: eno; PRK00077 910348008723 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 910348008724 dimer interface [polypeptide binding]; other site 910348008725 metal binding site [ion binding]; metal-binding site 910348008726 substrate binding pocket [chemical binding]; other site 910348008727 CTP synthetase; Validated; Region: pyrG; PRK05380 910348008728 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 910348008729 Catalytic site [active] 910348008730 active site 910348008731 UTP binding site [chemical binding]; other site 910348008732 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 910348008733 active site 910348008734 putative oxyanion hole; other site 910348008735 catalytic triad [active] 910348008736 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 910348008737 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 910348008738 homodimer interface [polypeptide binding]; other site 910348008739 metal binding site [ion binding]; metal-binding site 910348008740 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 910348008741 homodimer interface [polypeptide binding]; other site 910348008742 active site 910348008743 putative chemical substrate binding site [chemical binding]; other site 910348008744 metal binding site [ion binding]; metal-binding site 910348008745 toxin MazF; Provisional; Region: PRK09907 910348008746 antitoxin MazE; Provisional; Region: PRK09798 910348008747 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 910348008748 HD domain; Region: HD_4; pfam13328 910348008749 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 910348008750 synthetase active site [active] 910348008751 NTP binding site [chemical binding]; other site 910348008752 metal binding site [ion binding]; metal-binding site 910348008753 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 910348008754 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 910348008755 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 910348008756 TRAM domain; Region: TRAM; pfam01938 910348008757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348008758 S-adenosylmethionine binding site [chemical binding]; other site 910348008759 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 910348008760 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 910348008761 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 910348008762 dimerization interface [polypeptide binding]; other site 910348008763 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 910348008764 dimer interface [polypeptide binding]; other site 910348008765 phosphorylation site [posttranslational modification] 910348008766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348008767 ATP binding site [chemical binding]; other site 910348008768 Mg2+ binding site [ion binding]; other site 910348008769 G-X-G motif; other site 910348008770 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 910348008771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348008772 active site 910348008773 phosphorylation site [posttranslational modification] 910348008774 intermolecular recognition site; other site 910348008775 dimerization interface [polypeptide binding]; other site 910348008776 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 910348008777 putative binding surface; other site 910348008778 active site 910348008779 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 910348008780 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 910348008781 active site 910348008782 tetramer interface [polypeptide binding]; other site 910348008783 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 910348008784 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 910348008785 active site 910348008786 tetramer interface [polypeptide binding]; other site 910348008787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348008788 D-galactonate transporter; Region: 2A0114; TIGR00893 910348008789 putative substrate translocation pore; other site 910348008790 flavodoxin; Provisional; Region: PRK08105 910348008791 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 910348008792 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 910348008793 probable active site [active] 910348008794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 910348008795 SecY interacting protein Syd; Provisional; Region: PRK04968 910348008796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 910348008797 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 910348008798 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 910348008799 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 910348008800 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 910348008801 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 910348008802 serine transporter; Region: stp; TIGR00814 910348008803 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 910348008804 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 910348008805 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 910348008806 flap endonuclease-like protein; Provisional; Region: PRK09482 910348008807 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 910348008808 active site 910348008809 putative 5' ssDNA interaction site; other site 910348008810 metal binding site 3; metal-binding site 910348008811 metal binding site 1 [ion binding]; metal-binding site 910348008812 metal binding site 2 [ion binding]; metal-binding site 910348008813 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 910348008814 putative DNA binding site [nucleotide binding]; other site 910348008815 putative metal binding site [ion binding]; other site 910348008816 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 910348008817 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 910348008818 dimer interface [polypeptide binding]; other site 910348008819 active site 910348008820 metal binding site [ion binding]; metal-binding site 910348008821 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 910348008822 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 910348008823 intersubunit interface [polypeptide binding]; other site 910348008824 active site 910348008825 Zn2+ binding site [ion binding]; other site 910348008826 L-fucose transporter; Provisional; Region: PRK10133; cl17665 910348008827 L-fucose transporter; Provisional; Region: PRK10133; cl17665 910348008828 glucose/galactose transporter; Region: gluP; TIGR01272 910348008829 L-fucose isomerase; Provisional; Region: fucI; PRK10991 910348008830 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 910348008831 hexamer (dimer of trimers) interface [polypeptide binding]; other site 910348008832 trimer interface [polypeptide binding]; other site 910348008833 substrate binding site [chemical binding]; other site 910348008834 Mn binding site [ion binding]; other site 910348008835 L-fuculokinase; Provisional; Region: PRK10331 910348008836 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 910348008837 nucleotide binding site [chemical binding]; other site 910348008838 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 910348008839 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 910348008840 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 910348008841 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 910348008842 hypothetical protein; Provisional; Region: PRK10873 910348008843 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 910348008844 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348008845 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 910348008846 dimerization interface [polypeptide binding]; other site 910348008847 substrate binding pocket [chemical binding]; other site 910348008848 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 910348008849 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 910348008850 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 910348008851 catalytic residue [active] 910348008852 CsdA-binding activator; Provisional; Region: PRK15019 910348008853 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 910348008854 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 910348008855 putative ATP binding site [chemical binding]; other site 910348008856 putative substrate interface [chemical binding]; other site 910348008857 murein transglycosylase A; Provisional; Region: mltA; PRK11162 910348008858 MltA specific insert domain; Region: MltA; pfam03562 910348008859 3D domain; Region: 3D; pfam06725 910348008860 AMIN domain; Region: AMIN; pfam11741 910348008861 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 910348008862 active site 910348008863 metal binding site [ion binding]; metal-binding site 910348008864 N-acetylglutamate synthase; Validated; Region: PRK05279 910348008865 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 910348008866 putative nucleotide binding site [chemical binding]; other site 910348008867 putative substrate binding site [chemical binding]; other site 910348008868 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 910348008869 Coenzyme A binding pocket [chemical binding]; other site 910348008870 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 910348008871 AAA domain; Region: AAA_30; pfam13604 910348008872 Family description; Region: UvrD_C_2; pfam13538 910348008873 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 910348008874 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 910348008875 protease3; Provisional; Region: PRK15101 910348008876 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 910348008877 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 910348008878 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 910348008879 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 910348008880 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 910348008881 hypothetical protein; Provisional; Region: PRK10332 910348008882 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 910348008883 hypothetical protein; Provisional; Region: PRK11521 910348008884 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 910348008885 hypothetical protein; Provisional; Region: PRK10557 910348008886 thymidylate synthase; Reviewed; Region: thyA; PRK01827 910348008887 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 910348008888 dimerization interface [polypeptide binding]; other site 910348008889 active site 910348008890 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 910348008891 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 910348008892 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 910348008893 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 910348008894 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 910348008895 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 910348008896 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 910348008897 putative active site [active] 910348008898 Ap4A binding site [chemical binding]; other site 910348008899 nudix motif; other site 910348008900 putative metal binding site [ion binding]; other site 910348008901 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 910348008902 putative DNA-binding cleft [nucleotide binding]; other site 910348008903 putative DNA clevage site; other site 910348008904 molecular lever; other site 910348008905 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 910348008906 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 910348008907 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 910348008908 active site 910348008909 catalytic tetrad [active] 910348008910 lysophospholipid transporter LplT; Provisional; Region: PRK11195 910348008911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348008912 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 910348008913 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 910348008914 putative acyl-acceptor binding pocket; other site 910348008915 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 910348008916 acyl-activating enzyme (AAE) consensus motif; other site 910348008917 putative AMP binding site [chemical binding]; other site 910348008918 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 910348008919 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 910348008920 DNA binding site [nucleotide binding] 910348008921 domain linker motif; other site 910348008922 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 910348008923 dimerization interface (closed form) [polypeptide binding]; other site 910348008924 ligand binding site [chemical binding]; other site 910348008925 diaminopimelate decarboxylase; Provisional; Region: PRK11165 910348008926 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 910348008927 active site 910348008928 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 910348008929 substrate binding site [chemical binding]; other site 910348008930 catalytic residues [active] 910348008931 dimer interface [polypeptide binding]; other site 910348008932 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 910348008933 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348008934 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 910348008935 putative dimerization interface [polypeptide binding]; other site 910348008936 putative racemase; Provisional; Region: PRK10200 910348008937 aspartate racemase; Region: asp_race; TIGR00035 910348008938 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 910348008939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348008940 putative substrate translocation pore; other site 910348008941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348008942 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 910348008943 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 910348008944 NADP binding site [chemical binding]; other site 910348008945 homodimer interface [polypeptide binding]; other site 910348008946 active site 910348008947 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 910348008948 putative acyltransferase; Provisional; Region: PRK05790 910348008949 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 910348008950 dimer interface [polypeptide binding]; other site 910348008951 active site 910348008952 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 910348008953 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 910348008954 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 910348008955 DNA binding residues [nucleotide binding] 910348008956 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 910348008957 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 910348008958 Tetratricopeptide repeat; Region: TPR_3; pfam07720 910348008959 Tetratricopeptide repeat; Region: TPR_3; pfam07720 910348008960 transcriptional regulator; Provisional; Region: PRK11906 910348008961 Tetratricopeptide repeat; Region: TPR_2; pfam07719 910348008962 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 910348008963 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 910348008964 N-acetyl-D-glucosamine binding site [chemical binding]; other site 910348008965 catalytic residue [active] 910348008966 invasion protein OrgB; Provisional; Region: PRK15322 910348008967 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 910348008968 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 910348008969 Type III secretion needle MxiH like; Region: MxiH; cl09641 910348008970 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 910348008971 DNA binding residues [nucleotide binding] 910348008972 dimerization interface [polypeptide binding]; other site 910348008973 InvH outer membrane lipoprotein; Region: InvH; pfam04741 910348008974 type III secretion system protein SpaS; Validated; Region: PRK08156 910348008975 type III secretion system protein SpaS; Validated; Region: PRK08156 910348008976 type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401 910348008977 type III secretion system protein SpaQ; Provisional; Region: PRK15333 910348008978 FliP family; Region: FliP; cl00593 910348008979 type III secretion system protein SpaO; Validated; Region: PRK08158 910348008980 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 910348008981 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 910348008982 Peptidase family M23; Region: Peptidase_M23; pfam01551 910348008983 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 910348008984 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 910348008985 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 910348008986 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 910348008987 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 910348008988 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 910348008989 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 910348008990 catalytic loop [active] 910348008991 iron binding site [ion binding]; other site 910348008992 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 910348008993 GAF domain; Region: GAF; cl17456 910348008994 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 910348008995 PAS domain; Region: PAS; smart00091 910348008996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348008997 Walker A motif; other site 910348008998 ATP binding site [chemical binding]; other site 910348008999 Walker B motif; other site 910348009000 arginine finger; other site 910348009001 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 910348009002 peptidase; Reviewed; Region: PRK13004 910348009003 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 910348009004 putative metal binding site [ion binding]; other site 910348009005 putative dimer interface [polypeptide binding]; other site 910348009006 D-hydantoinase; Region: D-hydantoinase; TIGR02033 910348009007 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 910348009008 tetramer interface [polypeptide binding]; other site 910348009009 active site 910348009010 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 910348009011 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 910348009012 XdhC Rossmann domain; Region: XdhC_C; pfam13478 910348009013 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 910348009014 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 910348009015 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 910348009016 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 910348009017 Ligand binding site; other site 910348009018 metal-binding site 910348009019 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 910348009020 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 910348009021 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 910348009022 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 910348009023 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 910348009024 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 910348009025 active site 910348009026 putative substrate binding pocket [chemical binding]; other site 910348009027 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 910348009028 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 910348009029 putative hypoxanthine oxidase; Provisional; Region: PRK09800 910348009030 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 910348009031 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 910348009032 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 910348009033 uracil-xanthine permease; Region: ncs2; TIGR00801 910348009034 guanine deaminase; Provisional; Region: PRK09228 910348009035 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 910348009036 active site 910348009037 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 910348009038 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 910348009039 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 910348009040 4Fe-4S binding domain; Region: Fer4; pfam00037 910348009041 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 910348009042 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 910348009043 xanthine permease; Region: pbuX; TIGR03173 910348009044 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 910348009045 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 910348009046 active site 910348009047 metal binding site [ion binding]; metal-binding site 910348009048 nudix motif; other site 910348009049 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 910348009050 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 910348009051 dimer interface [polypeptide binding]; other site 910348009052 putative anticodon binding site; other site 910348009053 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 910348009054 motif 1; other site 910348009055 active site 910348009056 motif 2; other site 910348009057 motif 3; other site 910348009058 peptide chain release factor 2; Provisional; Region: PRK08787 910348009059 This domain is found in peptide chain release factors; Region: PCRF; smart00937 910348009060 RF-1 domain; Region: RF-1; pfam00472 910348009061 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 910348009062 DHH family; Region: DHH; pfam01368 910348009063 DHHA1 domain; Region: DHHA1; pfam02272 910348009064 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 910348009065 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 910348009066 dimerization domain [polypeptide binding]; other site 910348009067 dimer interface [polypeptide binding]; other site 910348009068 catalytic residues [active] 910348009069 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 910348009070 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 910348009071 active site 910348009072 Int/Topo IB signature motif; other site 910348009073 flavodoxin FldB; Provisional; Region: PRK12359 910348009074 putative global regulator; Reviewed; Region: PRK09559 910348009075 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 910348009076 hemolysin; Provisional; Region: PRK15087 910348009077 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 910348009078 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 910348009079 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 910348009080 classical (c) SDRs; Region: SDR_c; cd05233 910348009081 NAD(P) binding site [chemical binding]; other site 910348009082 active site 910348009083 glycine dehydrogenase; Provisional; Region: PRK05367 910348009084 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 910348009085 tetramer interface [polypeptide binding]; other site 910348009086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348009087 catalytic residue [active] 910348009088 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 910348009089 tetramer interface [polypeptide binding]; other site 910348009090 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348009091 catalytic residue [active] 910348009092 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 910348009093 lipoyl attachment site [posttranslational modification]; other site 910348009094 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 910348009095 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 910348009096 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 910348009097 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 910348009098 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 910348009099 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 910348009100 proline aminopeptidase P II; Provisional; Region: PRK10879 910348009101 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 910348009102 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 910348009103 active site 910348009104 hypothetical protein; Reviewed; Region: PRK01736 910348009105 Z-ring-associated protein; Provisional; Region: PRK10972 910348009106 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 910348009107 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 910348009108 ligand binding site [chemical binding]; other site 910348009109 NAD binding site [chemical binding]; other site 910348009110 tetramer interface [polypeptide binding]; other site 910348009111 catalytic site [active] 910348009112 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 910348009113 L-serine binding site [chemical binding]; other site 910348009114 ACT domain interface; other site 910348009115 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 910348009116 tetramer (dimer of dimers) interface [polypeptide binding]; other site 910348009117 active site 910348009118 dimer interface [polypeptide binding]; other site 910348009119 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 910348009120 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348009121 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 910348009122 putative dimerization interface [polypeptide binding]; other site 910348009123 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 910348009124 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 910348009125 active site 910348009126 substrate binding site [chemical binding]; other site 910348009127 coenzyme B12 binding site [chemical binding]; other site 910348009128 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 910348009129 B12 binding site [chemical binding]; other site 910348009130 cobalt ligand [ion binding]; other site 910348009131 membrane ATPase/protein kinase; Provisional; Region: PRK09435 910348009132 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 910348009133 Walker A; other site 910348009134 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 910348009135 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 910348009136 substrate binding site [chemical binding]; other site 910348009137 oxyanion hole (OAH) forming residues; other site 910348009138 trimer interface [polypeptide binding]; other site 910348009139 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 910348009140 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 910348009141 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 910348009142 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348009143 Transcriptional regulator [Transcription]; Region: LysR; COG0583 910348009144 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 910348009145 dimerization interface [polypeptide binding]; other site 910348009146 oxidative stress defense protein; Provisional; Region: PRK11087 910348009147 Uncharacterized conserved protein [Function unknown]; Region: COG2968 910348009148 arginine exporter protein; Provisional; Region: PRK09304 910348009149 mechanosensitive channel MscS; Provisional; Region: PRK10334 910348009150 Mechanosensitive ion channel; Region: MS_channel; pfam00924 910348009151 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 910348009152 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 910348009153 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 910348009154 active site 910348009155 intersubunit interface [polypeptide binding]; other site 910348009156 zinc binding site [ion binding]; other site 910348009157 Na+ binding site [ion binding]; other site 910348009158 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 910348009159 Phosphoglycerate kinase; Region: PGK; pfam00162 910348009160 substrate binding site [chemical binding]; other site 910348009161 hinge regions; other site 910348009162 ADP binding site [chemical binding]; other site 910348009163 catalytic site [active] 910348009164 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 910348009165 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 910348009166 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 910348009167 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 910348009168 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 910348009169 active site 910348009170 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 910348009171 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 910348009172 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 910348009173 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 910348009174 putative active site [active] 910348009175 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 910348009176 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 910348009177 putative NAD(P) binding site [chemical binding]; other site 910348009178 catalytic Zn binding site [ion binding]; other site 910348009179 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 910348009180 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 910348009181 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 910348009182 active site 910348009183 P-loop; other site 910348009184 phosphorylation site [posttranslational modification] 910348009185 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 910348009186 active site 910348009187 phosphorylation site [posttranslational modification] 910348009188 transketolase; Reviewed; Region: PRK12753 910348009189 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 910348009190 TPP-binding site [chemical binding]; other site 910348009191 dimer interface [polypeptide binding]; other site 910348009192 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 910348009193 PYR/PP interface [polypeptide binding]; other site 910348009194 dimer interface [polypeptide binding]; other site 910348009195 TPP binding site [chemical binding]; other site 910348009196 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 910348009197 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 910348009198 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 910348009199 agmatinase; Region: agmatinase; TIGR01230 910348009200 oligomer interface [polypeptide binding]; other site 910348009201 putative active site [active] 910348009202 Mn binding site [ion binding]; other site 910348009203 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 910348009204 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 910348009205 dimer interface [polypeptide binding]; other site 910348009206 active site 910348009207 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 910348009208 catalytic residues [active] 910348009209 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 910348009210 S-adenosylmethionine synthetase; Validated; Region: PRK05250 910348009211 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 910348009212 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 910348009213 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 910348009214 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 910348009215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348009216 putative substrate translocation pore; other site 910348009217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348009218 hypothetical protein; Provisional; Region: PRK04860 910348009219 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 910348009220 DNA-specific endonuclease I; Provisional; Region: PRK15137 910348009221 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 910348009222 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 910348009223 RNA methyltransferase, RsmE family; Region: TIGR00046 910348009224 glutathione synthetase; Provisional; Region: PRK05246 910348009225 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 910348009226 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 910348009227 hypothetical protein; Validated; Region: PRK00228 910348009228 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 910348009229 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 910348009230 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 910348009231 Walker A motif; other site 910348009232 ATP binding site [chemical binding]; other site 910348009233 Walker B motif; other site 910348009234 YGGT family; Region: YGGT; pfam02325 910348009235 YGGT family; Region: YGGT; pfam02325 910348009236 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 910348009237 active site 910348009238 dimerization interface [polypeptide binding]; other site 910348009239 HemN family oxidoreductase; Provisional; Region: PRK05660 910348009240 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 910348009241 FeS/SAM binding site; other site 910348009242 HemN C-terminal domain; Region: HemN_C; pfam06969 910348009243 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 910348009244 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 910348009245 homodimer interface [polypeptide binding]; other site 910348009246 active site 910348009247 hypothetical protein; Provisional; Region: PRK10626 910348009248 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 910348009249 hypothetical protein; Provisional; Region: PRK11702 910348009250 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 910348009251 adenine DNA glycosylase; Provisional; Region: PRK10880 910348009252 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 910348009253 minor groove reading motif; other site 910348009254 helix-hairpin-helix signature motif; other site 910348009255 substrate binding pocket [chemical binding]; other site 910348009256 active site 910348009257 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 910348009258 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 910348009259 DNA binding and oxoG recognition site [nucleotide binding] 910348009260 oxidative damage protection protein; Provisional; Region: PRK05408 910348009261 murein transglycosylase C; Provisional; Region: mltC; PRK11671 910348009262 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 910348009263 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 910348009264 N-acetyl-D-glucosamine binding site [chemical binding]; other site 910348009265 catalytic residue [active] 910348009266 nucleoside transporter; Region: 2A0110; TIGR00889 910348009267 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 910348009268 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 910348009269 Orn/Lys/Arg decarboxylase, major domain; Region: OKR_DC_1; pfam01276 910348009270 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 910348009271 homodimer interface [polypeptide binding]; other site 910348009272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348009273 catalytic residue [active] 910348009274 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 910348009275 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 910348009276 putative general secretion pathway protein YghD; Provisional; Region: PRK09731 910348009277 GspL-like protein; Provisional; Region: PRK09662 910348009278 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 910348009279 type II secretion system protein J; Region: gspJ; TIGR01711 910348009280 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 910348009281 type II secretion system protein I; Region: gspI; TIGR01707 910348009282 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 910348009283 Type II transport protein GspH; Region: GspH; pfam12019 910348009284 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 910348009285 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 910348009286 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 910348009287 type II secretion system protein F; Region: GspF; TIGR02120 910348009288 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 910348009289 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 910348009290 type II secretion system protein E; Region: type_II_gspE; TIGR02533 910348009291 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 910348009292 Walker A motif; other site 910348009293 ATP binding site [chemical binding]; other site 910348009294 Walker B motif; other site 910348009295 type II secretion system protein D; Region: type_II_gspD; TIGR02517 910348009296 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 910348009297 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 910348009298 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 910348009299 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 910348009300 putative type II secretion protein GspC; Provisional; Region: PRK09681 910348009301 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 910348009302 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 910348009303 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 910348009304 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 910348009305 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 910348009306 Domain of unknown function (DUF4092); Region: DUF4092; pfam13322 910348009307 Peptidase M60-like family; Region: M60-like; pfam13402 910348009308 glycolate transporter; Provisional; Region: PRK09695 910348009309 L-lactate permease; Region: Lactate_perm; cl00701 910348009310 hypothetical protein; Provisional; Region: PRK09732 910348009311 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 910348009312 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 910348009313 Cysteine-rich domain; Region: CCG; pfam02754 910348009314 Cysteine-rich domain; Region: CCG; pfam02754 910348009315 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 910348009316 FAD binding domain; Region: FAD_binding_4; pfam01565 910348009317 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 910348009318 FAD binding domain; Region: FAD_binding_4; pfam01565 910348009319 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 910348009320 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 910348009321 DNA-binding site [nucleotide binding]; DNA binding site 910348009322 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 910348009323 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 910348009324 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 910348009325 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 910348009326 NAD(P) binding site [chemical binding]; other site 910348009327 active site 910348009328 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 910348009329 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 910348009330 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 910348009331 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 910348009332 catalytic residue [active] 910348009333 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 910348009334 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 910348009335 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 910348009336 Predicted permeases [General function prediction only]; Region: COG0795 910348009337 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 910348009338 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 910348009339 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 910348009340 Thymidylate kinase; Region: Thymidylate_kin; pfam02223 910348009341 active site 910348009342 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 910348009343 TMP-binding site; other site 910348009344 ATP-binding site [chemical binding]; other site 910348009345 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 910348009346 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 910348009347 TMP-binding site; other site 910348009348 ATP-binding site [chemical binding]; other site 910348009349 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 910348009350 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 910348009351 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 910348009352 CHAP domain; Region: CHAP; pfam05257 910348009353 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 910348009354 putative S-transferase; Provisional; Region: PRK11752 910348009355 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 910348009356 C-terminal domain interface [polypeptide binding]; other site 910348009357 GSH binding site (G-site) [chemical binding]; other site 910348009358 dimer interface [polypeptide binding]; other site 910348009359 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 910348009360 dimer interface [polypeptide binding]; other site 910348009361 N-terminal domain interface [polypeptide binding]; other site 910348009362 active site 910348009363 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 910348009364 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 910348009365 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 910348009366 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 910348009367 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 910348009368 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 910348009369 putative substrate-binding site; other site 910348009370 nickel binding site [ion binding]; other site 910348009371 hydrogenase 2 large subunit; Provisional; Region: PRK10467 910348009372 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 910348009373 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 910348009374 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 910348009375 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 910348009376 4Fe-4S binding domain; Region: Fer4_6; pfam12837 910348009377 hydrogenase 2 small subunit; Provisional; Region: PRK10468 910348009378 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 910348009379 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 910348009380 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 910348009381 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 910348009382 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 910348009383 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 910348009384 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 910348009385 active site 910348009386 catalytic tetrad [active] 910348009387 hypothetical protein; Provisional; Region: PRK05208 910348009388 oxidoreductase; Provisional; Region: PRK07985 910348009389 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 910348009390 NAD binding site [chemical binding]; other site 910348009391 metal binding site [ion binding]; metal-binding site 910348009392 active site 910348009393 biopolymer transport protein ExbD; Provisional; Region: PRK11267 910348009394 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 910348009395 biopolymer transport protein ExbB; Provisional; Region: PRK10414 910348009396 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 910348009397 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 910348009398 catalytic residue [active] 910348009399 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 910348009400 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 910348009401 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 910348009402 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 910348009403 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 910348009404 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348009405 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348009406 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 910348009407 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 910348009408 dimer interface [polypeptide binding]; other site 910348009409 active site 910348009410 metal binding site [ion binding]; metal-binding site 910348009411 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 910348009412 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 910348009413 active site 910348009414 catalytic tetrad [active] 910348009415 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 910348009416 putative outer membrane lipoprotein; Provisional; Region: PRK09973 910348009417 hypothetical protein; Provisional; Region: PRK01254 910348009418 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 910348009419 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 910348009420 FtsI repressor; Provisional; Region: PRK10883 910348009421 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 910348009422 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 910348009423 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 910348009424 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 910348009425 putative acyl-acceptor binding pocket; other site 910348009426 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 910348009427 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 910348009428 CAP-like domain; other site 910348009429 active site 910348009430 primary dimer interface [polypeptide binding]; other site 910348009431 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 910348009432 putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755 910348009433 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 910348009434 peptide binding site [polypeptide binding]; other site 910348009435 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 910348009436 toxin interface [polypeptide binding]; other site 910348009437 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 910348009438 Zn binding site [ion binding]; other site 910348009439 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 910348009440 non-specific DNA binding site [nucleotide binding]; other site 910348009441 salt bridge; other site 910348009442 sequence-specific DNA binding site [nucleotide binding]; other site 910348009443 Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869 910348009444 peptide binding site [polypeptide binding]; other site 910348009445 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 910348009446 TIGR00156 family protein; Region: TIGR00156 910348009447 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 910348009448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348009449 active site 910348009450 phosphorylation site [posttranslational modification] 910348009451 intermolecular recognition site; other site 910348009452 dimerization interface [polypeptide binding]; other site 910348009453 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 910348009454 DNA binding site [nucleotide binding] 910348009455 sensor protein QseC; Provisional; Region: PRK10337 910348009456 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 910348009457 dimer interface [polypeptide binding]; other site 910348009458 phosphorylation site [posttranslational modification] 910348009459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348009460 ATP binding site [chemical binding]; other site 910348009461 Mg2+ binding site [ion binding]; other site 910348009462 G-X-G motif; other site 910348009463 Uncharacterized conserved protein [Function unknown]; Region: COG1359 910348009464 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 910348009465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348009466 ATP binding site [chemical binding]; other site 910348009467 Mg2+ binding site [ion binding]; other site 910348009468 G-X-G motif; other site 910348009469 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 910348009470 anchoring element; other site 910348009471 dimer interface [polypeptide binding]; other site 910348009472 ATP binding site [chemical binding]; other site 910348009473 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 910348009474 active site 910348009475 metal binding site [ion binding]; metal-binding site 910348009476 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 910348009477 esterase YqiA; Provisional; Region: PRK11071 910348009478 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 910348009479 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 910348009480 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 910348009481 hexamer interface [polypeptide binding]; other site 910348009482 putative dehydrogenase; Provisional; Region: PRK11039 910348009483 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 910348009484 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 910348009485 dimer interface [polypeptide binding]; other site 910348009486 ADP-ribose binding site [chemical binding]; other site 910348009487 active site 910348009488 nudix motif; other site 910348009489 metal binding site [ion binding]; metal-binding site 910348009490 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 910348009491 hypothetical protein; Provisional; Region: PRK11653 910348009492 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 910348009493 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 910348009494 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 910348009495 putative active site [active] 910348009496 metal binding site [ion binding]; metal-binding site 910348009497 zinc transporter ZupT; Provisional; Region: PRK04201 910348009498 ZIP Zinc transporter; Region: Zip; pfam02535 910348009499 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 910348009500 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 910348009501 putative fimbrial protein; Provisional; Region: PRK09733 910348009502 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 910348009503 PapC N-terminal domain; Region: PapC_N; pfam13954 910348009504 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 910348009505 PapC C-terminal domain; Region: PapC_C; pfam13953 910348009506 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 910348009507 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 910348009508 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 910348009509 Fimbrial protein; Region: Fimbrial; pfam00419 910348009510 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 910348009511 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 910348009512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 910348009513 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 910348009514 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 910348009515 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 910348009516 putative ribose interaction site [chemical binding]; other site 910348009517 putative ADP binding site [chemical binding]; other site 910348009518 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 910348009519 active site 910348009520 nucleotide binding site [chemical binding]; other site 910348009521 HIGH motif; other site 910348009522 KMSKS motif; other site 910348009523 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 910348009524 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 910348009525 metal binding triad; other site 910348009526 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 910348009527 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 910348009528 metal binding triad; other site 910348009529 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 910348009530 Uncharacterized conserved protein [Function unknown]; Region: COG3025 910348009531 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 910348009532 putative active site [active] 910348009533 putative metal binding residues [ion binding]; other site 910348009534 signature motif; other site 910348009535 putative triphosphate binding site [ion binding]; other site 910348009536 CHAD domain; Region: CHAD; pfam05235 910348009537 SH3 domain-containing protein; Provisional; Region: PRK10884 910348009538 Bacterial SH3 domain homologues; Region: SH3b; smart00287 910348009539 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 910348009540 Poly A polymerase head domain; Region: PolyA_pol; pfam01743 910348009541 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 910348009542 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 910348009543 Zn2+ binding site [ion binding]; other site 910348009544 Mg2+ binding site [ion binding]; other site 910348009545 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 910348009546 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 910348009547 homooctamer interface [polypeptide binding]; other site 910348009548 active site 910348009549 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 910348009550 transcriptional activator TtdR; Provisional; Region: PRK09801 910348009551 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348009552 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 910348009553 putative effector binding pocket; other site 910348009554 putative dimerization interface [polypeptide binding]; other site 910348009555 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 910348009556 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 910348009557 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 910348009558 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 910348009559 transmembrane helices; other site 910348009560 UGMP family protein; Validated; Region: PRK09604 910348009561 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 910348009562 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 910348009563 DNA primase; Validated; Region: dnaG; PRK05667 910348009564 CHC2 zinc finger; Region: zf-CHC2; pfam01807 910348009565 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 910348009566 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 910348009567 active site 910348009568 metal binding site [ion binding]; metal-binding site 910348009569 interdomain interaction site; other site 910348009570 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 910348009571 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 910348009572 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 910348009573 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 910348009574 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 910348009575 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 910348009576 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 910348009577 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 910348009578 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 910348009579 DNA binding residues [nucleotide binding] 910348009580 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 910348009581 active site 910348009582 SUMO-1 interface [polypeptide binding]; other site 910348009583 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 910348009584 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 910348009585 Antirestriction protein; Region: Antirestrict; pfam03230 910348009586 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 910348009587 hypothetical protein; Provisional; Region: PRK09945 910348009588 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 910348009589 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 910348009590 Autotransporter beta-domain; Region: Autotransporter; pfam03797 910348009591 Predicted transcriptional regulator [Transcription]; Region: COG2378 910348009592 WYL domain; Region: WYL; pfam13280 910348009593 Domain of unknown function (DUF932); Region: DUF932; pfam06067 910348009594 Predicted GTPase [General function prediction only]; Region: COG3596 910348009595 YfjP GTPase; Region: YfjP; cd11383 910348009596 G1 box; other site 910348009597 GTP/Mg2+ binding site [chemical binding]; other site 910348009598 Switch I region; other site 910348009599 G2 box; other site 910348009600 Switch II region; other site 910348009601 G3 box; other site 910348009602 G4 box; other site 910348009603 G5 box; other site 910348009604 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 910348009605 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 910348009606 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 910348009607 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 910348009608 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 910348009609 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 910348009610 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 910348009611 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 910348009612 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 910348009613 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 910348009614 Walker A/P-loop; other site 910348009615 ATP binding site [chemical binding]; other site 910348009616 Q-loop/lid; other site 910348009617 ABC transporter signature motif; other site 910348009618 Walker B; other site 910348009619 D-loop; other site 910348009620 H-loop/switch region; other site 910348009621 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 910348009622 ABC-2 type transporter; Region: ABC2_membrane; cl17235 910348009623 HTH-like domain; Region: HTH_21; pfam13276 910348009624 Integrase core domain; Region: rve; pfam00665 910348009625 Integrase core domain; Region: rve_3; pfam13683 910348009626 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 910348009627 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 910348009628 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 910348009629 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 910348009630 Fic/DOC family; Region: Fic; pfam02661 910348009631 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 910348009632 active site 910348009633 DNA binding site [nucleotide binding] 910348009634 Int/Topo IB signature motif; other site 910348009635 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 910348009636 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 910348009637 FAD binding pocket [chemical binding]; other site 910348009638 FAD binding motif [chemical binding]; other site 910348009639 phosphate binding motif [ion binding]; other site 910348009640 NAD binding pocket [chemical binding]; other site 910348009641 Predicted transcriptional regulators [Transcription]; Region: COG1695 910348009642 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 910348009643 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 910348009644 PAS fold; Region: PAS_3; pfam08447 910348009645 putative active site [active] 910348009646 heme pocket [chemical binding]; other site 910348009647 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 910348009648 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 910348009649 dimer interface [polypeptide binding]; other site 910348009650 putative CheW interface [polypeptide binding]; other site 910348009651 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 910348009652 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 910348009653 inhibitor-cofactor binding pocket; inhibition site 910348009654 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348009655 catalytic residue [active] 910348009656 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 910348009657 dimer interface [polypeptide binding]; other site 910348009658 putative tRNA-binding site [nucleotide binding]; other site 910348009659 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 910348009660 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 910348009661 DNA binding site [nucleotide binding] 910348009662 domain linker motif; other site 910348009663 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 910348009664 putative dimerization interface [polypeptide binding]; other site 910348009665 putative ligand binding site [chemical binding]; other site 910348009666 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 910348009667 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 910348009668 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 910348009669 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 910348009670 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 910348009671 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 910348009672 inner membrane transporter YjeM; Provisional; Region: PRK15238 910348009673 alpha-glucosidase; Provisional; Region: PRK10137 910348009674 Protein of unknown function, DUF608; Region: DUF608; pfam04685 910348009675 Trehalase; Region: Trehalase; cl17346 910348009676 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 910348009677 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 910348009678 active site 910348009679 FMN binding site [chemical binding]; other site 910348009680 2,4-decadienoyl-CoA binding site; other site 910348009681 catalytic residue [active] 910348009682 4Fe-4S cluster binding site [ion binding]; other site 910348009683 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 910348009684 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 910348009685 non-specific DNA binding site [nucleotide binding]; other site 910348009686 salt bridge; other site 910348009687 sequence-specific DNA binding site [nucleotide binding]; other site 910348009688 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 910348009689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348009690 S-adenosylmethionine binding site [chemical binding]; other site 910348009691 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 910348009692 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 910348009693 putative active site [active] 910348009694 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 910348009695 serine/threonine transporter SstT; Provisional; Region: PRK13628 910348009696 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 910348009697 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 910348009698 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 910348009699 galactarate dehydratase; Region: galactar-dH20; TIGR03248 910348009700 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 910348009701 Glucuronate isomerase; Region: UxaC; pfam02614 910348009702 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 910348009703 D-galactonate transporter; Region: 2A0114; TIGR00893 910348009704 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348009705 putative substrate translocation pore; other site 910348009706 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 910348009707 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 910348009708 CS1 type fimbrial major subunit; Region: Fimbrial_CS1; pfam04449 910348009709 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 910348009710 putative fimbrial protein TcfA; Provisional; Region: PRK15308 910348009711 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 910348009712 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 910348009713 DNA-binding site [nucleotide binding]; DNA binding site 910348009714 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 910348009715 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 910348009716 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 910348009717 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 910348009718 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 910348009719 Predicted membrane protein [Function unknown]; Region: COG5393 910348009720 Predicted membrane protein [Function unknown]; Region: COG2259 910348009721 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 910348009722 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 910348009723 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 910348009724 putative dimer interface [polypeptide binding]; other site 910348009725 N-terminal domain interface [polypeptide binding]; other site 910348009726 putative substrate binding pocket (H-site) [chemical binding]; other site 910348009727 Predicted membrane protein [Function unknown]; Region: COG3152 910348009728 Predicted membrane protein [Function unknown]; Region: COG3152 910348009729 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348009730 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 910348009731 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 910348009732 dimerization interface [polypeptide binding]; other site 910348009733 Pirin-related protein [General function prediction only]; Region: COG1741 910348009734 Pirin; Region: Pirin; pfam02678 910348009735 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 910348009736 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 910348009737 serine transporter; Region: stp; TIGR00814 910348009738 L-serine dehydratase TdcG; Provisional; Region: PRK15040 910348009739 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 910348009740 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 910348009741 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 910348009742 homotrimer interaction site [polypeptide binding]; other site 910348009743 putative active site [active] 910348009744 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 910348009745 Pyruvate formate lyase 1; Region: PFL1; cd01678 910348009746 coenzyme A binding site [chemical binding]; other site 910348009747 active site 910348009748 catalytic residues [active] 910348009749 glycine loop; other site 910348009750 propionate/acetate kinase; Provisional; Region: PRK12379 910348009751 Acetokinase family; Region: Acetate_kinase; cl17229 910348009752 threonine/serine transporter TdcC; Provisional; Region: PRK13629 910348009753 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 910348009754 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 910348009755 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 910348009756 tetramer interface [polypeptide binding]; other site 910348009757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348009758 catalytic residue [active] 910348009759 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 910348009760 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348009761 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 910348009762 putative substrate binding pocket [chemical binding]; other site 910348009763 putative dimerization interface [polypeptide binding]; other site 910348009764 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 910348009765 hypothetical protein; Provisional; Region: PRK09716 910348009766 glycerate kinase I; Provisional; Region: PRK10342 910348009767 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 910348009768 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 910348009769 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 910348009770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348009771 D-galactonate transporter; Region: 2A0114; TIGR00893 910348009772 putative substrate translocation pore; other site 910348009773 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 910348009774 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 910348009775 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 910348009776 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 910348009777 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 910348009778 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 910348009779 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 910348009780 active site 910348009781 phosphorylation site [posttranslational modification] 910348009782 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 910348009783 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 910348009784 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 910348009785 active pocket/dimerization site; other site 910348009786 active site 910348009787 phosphorylation site [posttranslational modification] 910348009788 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 910348009789 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 910348009790 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 910348009791 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 910348009792 dimer interface [polypeptide binding]; other site 910348009793 active site 910348009794 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 910348009795 putative active site [active] 910348009796 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453 910348009797 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 910348009798 active site 910348009799 intersubunit interface [polypeptide binding]; other site 910348009800 zinc binding site [ion binding]; other site 910348009801 Na+ binding site [ion binding]; other site 910348009802 PTS system N-acetylgalactosamine-specific transporter subunit IIB; Provisional; Region: PRK09756 910348009803 active site 910348009804 phosphorylation site [posttranslational modification] 910348009805 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 910348009806 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 910348009807 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 910348009808 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 910348009809 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 910348009810 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 910348009811 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 910348009812 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 910348009813 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 910348009814 Fimbrial protein; Region: Fimbrial; pfam00419 910348009815 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 910348009816 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 910348009817 putative SAM binding site [chemical binding]; other site 910348009818 putative homodimer interface [polypeptide binding]; other site 910348009819 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 910348009820 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 910348009821 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 910348009822 putative ligand binding site [chemical binding]; other site 910348009823 TIGR00252 family protein; Region: TIGR00252 910348009824 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 910348009825 active site 910348009826 dimer interface [polypeptide binding]; other site 910348009827 outer membrane lipoprotein; Provisional; Region: PRK11023 910348009828 BON domain; Region: BON; pfam04972 910348009829 BON domain; Region: BON; pfam04972 910348009830 Predicted permease; Region: DUF318; pfam03773 910348009831 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 910348009832 NADH(P)-binding; Region: NAD_binding_10; pfam13460 910348009833 NAD binding site [chemical binding]; other site 910348009834 active site 910348009835 intracellular protease, PfpI family; Region: PfpI; TIGR01382 910348009836 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 910348009837 proposed catalytic triad [active] 910348009838 conserved cys residue [active] 910348009839 hypothetical protein; Provisional; Region: PRK03467 910348009840 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 910348009841 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 910348009842 Coenzyme A binding pocket [chemical binding]; other site 910348009843 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 910348009844 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 910348009845 Peptidase family U32; Region: Peptidase_U32; pfam01136 910348009846 putative protease; Provisional; Region: PRK15447 910348009847 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 910348009848 hypothetical protein; Provisional; Region: PRK10508 910348009849 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 910348009850 tryptophan permease; Provisional; Region: PRK10483 910348009851 aromatic amino acid transport protein; Region: araaP; TIGR00837 910348009852 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 910348009853 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 910348009854 ATP binding site [chemical binding]; other site 910348009855 Mg++ binding site [ion binding]; other site 910348009856 motif III; other site 910348009857 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 910348009858 nucleotide binding region [chemical binding]; other site 910348009859 ATP-binding site [chemical binding]; other site 910348009860 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 910348009861 putative RNA binding site [nucleotide binding]; other site 910348009862 lipoprotein NlpI; Provisional; Region: PRK11189 910348009863 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 910348009864 binding surface 910348009865 TPR motif; other site 910348009866 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 910348009867 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 910348009868 trimer interface [polypeptide binding]; other site 910348009869 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 910348009870 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 910348009871 RNase E interface [polypeptide binding]; other site 910348009872 trimer interface [polypeptide binding]; other site 910348009873 active site 910348009874 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 910348009875 putative nucleic acid binding region [nucleotide binding]; other site 910348009876 G-X-X-G motif; other site 910348009877 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 910348009878 RNA binding site [nucleotide binding]; other site 910348009879 domain interface; other site 910348009880 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 910348009881 16S/18S rRNA binding site [nucleotide binding]; other site 910348009882 S13e-L30e interaction site [polypeptide binding]; other site 910348009883 25S rRNA binding site [nucleotide binding]; other site 910348009884 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 910348009885 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 910348009886 RNA binding site [nucleotide binding]; other site 910348009887 active site 910348009888 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 910348009889 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 910348009890 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 910348009891 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 910348009892 translation initiation factor IF-2; Region: IF-2; TIGR00487 910348009893 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 910348009894 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 910348009895 G1 box; other site 910348009896 putative GEF interaction site [polypeptide binding]; other site 910348009897 GTP/Mg2+ binding site [chemical binding]; other site 910348009898 Switch I region; other site 910348009899 G2 box; other site 910348009900 G3 box; other site 910348009901 Switch II region; other site 910348009902 G4 box; other site 910348009903 G5 box; other site 910348009904 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 910348009905 Translation-initiation factor 2; Region: IF-2; pfam11987 910348009906 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 910348009907 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 910348009908 NusA N-terminal domain; Region: NusA_N; pfam08529 910348009909 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 910348009910 RNA binding site [nucleotide binding]; other site 910348009911 homodimer interface [polypeptide binding]; other site 910348009912 NusA-like KH domain; Region: KH_5; pfam13184 910348009913 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 910348009914 G-X-X-G motif; other site 910348009915 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 910348009916 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 910348009917 ribosome maturation protein RimP; Reviewed; Region: PRK00092 910348009918 hypothetical protein; Provisional; Region: PRK14641 910348009919 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 910348009920 putative oligomer interface [polypeptide binding]; other site 910348009921 putative RNA binding site [nucleotide binding]; other site 910348009922 argininosuccinate synthase; Validated; Region: PRK05370 910348009923 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 910348009924 Sulfatase; Region: Sulfatase; pfam00884 910348009925 Preprotein translocase SecG subunit; Region: SecG; pfam03840 910348009926 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 910348009927 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 910348009928 active site 910348009929 substrate binding site [chemical binding]; other site 910348009930 metal binding site [ion binding]; metal-binding site 910348009931 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 910348009932 dihydropteroate synthase; Region: DHPS; TIGR01496 910348009933 substrate binding pocket [chemical binding]; other site 910348009934 dimer interface [polypeptide binding]; other site 910348009935 inhibitor binding site; inhibition site 910348009936 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 910348009937 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348009938 Walker A motif; other site 910348009939 ATP binding site [chemical binding]; other site 910348009940 Walker B motif; other site 910348009941 arginine finger; other site 910348009942 Peptidase family M41; Region: Peptidase_M41; pfam01434 910348009943 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 910348009944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348009945 S-adenosylmethionine binding site [chemical binding]; other site 910348009946 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 910348009947 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 910348009948 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 910348009949 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 910348009950 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 910348009951 Transposase IS200 like; Region: Y1_Tnp; pfam01797 910348009952 GTPase CgtA; Reviewed; Region: obgE; PRK12298 910348009953 GTP1/OBG; Region: GTP1_OBG; pfam01018 910348009954 Obg GTPase; Region: Obg; cd01898 910348009955 G1 box; other site 910348009956 GTP/Mg2+ binding site [chemical binding]; other site 910348009957 Switch I region; other site 910348009958 G2 box; other site 910348009959 G3 box; other site 910348009960 Switch II region; other site 910348009961 G4 box; other site 910348009962 G5 box; other site 910348009963 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 910348009964 EamA-like transporter family; Region: EamA; pfam00892 910348009965 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 910348009966 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 910348009967 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 910348009968 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 910348009969 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 910348009970 substrate binding pocket [chemical binding]; other site 910348009971 chain length determination region; other site 910348009972 substrate-Mg2+ binding site; other site 910348009973 catalytic residues [active] 910348009974 aspartate-rich region 1; other site 910348009975 active site lid residues [active] 910348009976 aspartate-rich region 2; other site 910348009977 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 910348009978 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 910348009979 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 910348009980 hinge; other site 910348009981 active site 910348009982 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 910348009983 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 910348009984 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 910348009985 mce related protein; Region: MCE; pfam02470 910348009986 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 910348009987 conserved hypothetical integral membrane protein; Region: TIGR00056 910348009988 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 910348009989 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 910348009990 Walker A/P-loop; other site 910348009991 ATP binding site [chemical binding]; other site 910348009992 Q-loop/lid; other site 910348009993 ABC transporter signature motif; other site 910348009994 Walker B; other site 910348009995 D-loop; other site 910348009996 H-loop/switch region; other site 910348009997 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 910348009998 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 910348009999 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 910348010000 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 910348010001 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 910348010002 putative active site [active] 910348010003 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 910348010004 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 910348010005 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 910348010006 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 910348010007 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 910348010008 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 910348010009 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 910348010010 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 910348010011 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 910348010012 Walker A/P-loop; other site 910348010013 ATP binding site [chemical binding]; other site 910348010014 Q-loop/lid; other site 910348010015 ABC transporter signature motif; other site 910348010016 Walker B; other site 910348010017 D-loop; other site 910348010018 H-loop/switch region; other site 910348010019 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 910348010020 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 910348010021 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 910348010022 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 910348010023 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 910348010024 30S subunit binding site; other site 910348010025 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 910348010026 active site 910348010027 phosphorylation site [posttranslational modification] 910348010028 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 910348010029 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 910348010030 dimerization domain swap beta strand [polypeptide binding]; other site 910348010031 regulatory protein interface [polypeptide binding]; other site 910348010032 active site 910348010033 regulatory phosphorylation site [posttranslational modification]; other site 910348010034 hypothetical protein; Provisional; Region: PRK10345 910348010035 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 910348010036 Transglycosylase; Region: Transgly; cl17702 910348010037 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 910348010038 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 910348010039 conserved cys residue [active] 910348010040 radical SAM protein, TIGR01212 family; Region: TIGR01212 910348010041 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 910348010042 FeS/SAM binding site; other site 910348010043 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 910348010044 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 910348010045 active site 910348010046 dimer interface [polypeptide binding]; other site 910348010047 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 910348010048 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 910348010049 active site 910348010050 FMN binding site [chemical binding]; other site 910348010051 substrate binding site [chemical binding]; other site 910348010052 3Fe-4S cluster binding site [ion binding]; other site 910348010053 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 910348010054 domain interface; other site 910348010055 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 910348010056 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 910348010057 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 910348010058 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 910348010059 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 910348010060 N-acetylmannosamine kinase; Provisional; Region: PRK05082 910348010061 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 910348010062 nucleotide binding site [chemical binding]; other site 910348010063 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 910348010064 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 910348010065 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 910348010066 putative active site cavity [active] 910348010067 putative sialic acid transporter; Provisional; Region: PRK03893 910348010068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348010069 putative substrate translocation pore; other site 910348010070 N-acetylneuraminate lyase; Region: nanA; TIGR00683 910348010071 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 910348010072 inhibitor site; inhibition site 910348010073 active site 910348010074 dimer interface [polypeptide binding]; other site 910348010075 catalytic residue [active] 910348010076 transcriptional regulator NanR; Provisional; Region: PRK03837 910348010077 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 910348010078 DNA-binding site [nucleotide binding]; DNA binding site 910348010079 FCD domain; Region: FCD; pfam07729 910348010080 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 910348010081 stringent starvation protein A; Provisional; Region: sspA; PRK09481 910348010082 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 910348010083 C-terminal domain interface [polypeptide binding]; other site 910348010084 putative GSH binding site (G-site) [chemical binding]; other site 910348010085 dimer interface [polypeptide binding]; other site 910348010086 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 910348010087 dimer interface [polypeptide binding]; other site 910348010088 N-terminal domain interface [polypeptide binding]; other site 910348010089 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 910348010090 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 910348010091 23S rRNA interface [nucleotide binding]; other site 910348010092 L3 interface [polypeptide binding]; other site 910348010093 Predicted ATPase [General function prediction only]; Region: COG1485 910348010094 serine endoprotease; Provisional; Region: PRK10139 910348010095 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 910348010096 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 910348010097 protein binding site [polypeptide binding]; other site 910348010098 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 910348010099 serine endoprotease; Provisional; Region: PRK10898 910348010100 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 910348010101 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 910348010102 malate dehydrogenase; Provisional; Region: PRK05086 910348010103 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 910348010104 NAD binding site [chemical binding]; other site 910348010105 dimerization interface [polypeptide binding]; other site 910348010106 Substrate binding site [chemical binding]; other site 910348010107 arginine repressor; Provisional; Region: PRK05066 910348010108 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 910348010109 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 910348010110 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 910348010111 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 910348010112 HlyD family secretion protein; Region: HlyD_3; pfam13437 910348010113 efflux system membrane protein; Provisional; Region: PRK11594 910348010114 transcriptional regulator; Provisional; Region: PRK10632 910348010115 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348010116 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 910348010117 putative effector binding pocket; other site 910348010118 dimerization interface [polypeptide binding]; other site 910348010119 protease TldD; Provisional; Region: tldD; PRK10735 910348010120 hypothetical protein; Provisional; Region: PRK10899 910348010121 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 910348010122 ribonuclease G; Provisional; Region: PRK11712 910348010123 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 910348010124 homodimer interface [polypeptide binding]; other site 910348010125 oligonucleotide binding site [chemical binding]; other site 910348010126 Maf-like protein; Region: Maf; pfam02545 910348010127 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 910348010128 active site 910348010129 dimer interface [polypeptide binding]; other site 910348010130 rod shape-determining protein MreD; Provisional; Region: PRK11060 910348010131 rod shape-determining protein MreC; Region: mreC; TIGR00219 910348010132 rod shape-determining protein MreC; Region: MreC; pfam04085 910348010133 rod shape-determining protein MreB; Provisional; Region: PRK13927 910348010134 MreB and similar proteins; Region: MreB_like; cd10225 910348010135 nucleotide binding site [chemical binding]; other site 910348010136 Mg binding site [ion binding]; other site 910348010137 putative protofilament interaction site [polypeptide binding]; other site 910348010138 RodZ interaction site [polypeptide binding]; other site 910348010139 regulatory protein CsrD; Provisional; Region: PRK11059 910348010140 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 910348010141 metal binding site [ion binding]; metal-binding site 910348010142 active site 910348010143 I-site; other site 910348010144 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 910348010145 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 910348010146 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 910348010147 NADP binding site [chemical binding]; other site 910348010148 dimer interface [polypeptide binding]; other site 910348010149 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 910348010150 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 910348010151 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 910348010152 carboxyltransferase (CT) interaction site; other site 910348010153 biotinylation site [posttranslational modification]; other site 910348010154 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 910348010155 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 910348010156 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 910348010157 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 910348010158 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 910348010159 Na binding site [ion binding]; other site 910348010160 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 910348010161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 910348010162 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 910348010163 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 910348010164 FMN binding site [chemical binding]; other site 910348010165 active site 910348010166 catalytic residues [active] 910348010167 substrate binding site [chemical binding]; other site 910348010168 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 910348010169 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 910348010170 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 910348010171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348010172 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 910348010173 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 910348010174 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 910348010175 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348010176 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 910348010177 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 910348010178 substrate binding pocket [chemical binding]; other site 910348010179 membrane-bound complex binding site; other site 910348010180 hinge residues; other site 910348010181 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 910348010182 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348010183 conserved gate region; other site 910348010184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348010185 dimer interface [polypeptide binding]; other site 910348010186 conserved gate region; other site 910348010187 putative PBP binding loops; other site 910348010188 ABC-ATPase subunit interface; other site 910348010189 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 910348010190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348010191 dimer interface [polypeptide binding]; other site 910348010192 conserved gate region; other site 910348010193 putative PBP binding loops; other site 910348010194 ABC-ATPase subunit interface; other site 910348010195 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 910348010196 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 910348010197 Walker A/P-loop; other site 910348010198 ATP binding site [chemical binding]; other site 910348010199 Q-loop/lid; other site 910348010200 ABC transporter signature motif; other site 910348010201 Walker B; other site 910348010202 D-loop; other site 910348010203 H-loop/switch region; other site 910348010204 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 910348010205 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 910348010206 putative metal binding site [ion binding]; other site 910348010207 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 910348010208 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 910348010209 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 910348010210 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 910348010211 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 910348010212 hypothetical protein; Validated; Region: PRK03430 910348010213 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 910348010214 active site 910348010215 catalytic residues [active] 910348010216 metal binding site [ion binding]; metal-binding site 910348010217 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 910348010218 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 910348010219 putative active site [active] 910348010220 putative cosubstrate binding site; other site 910348010221 substrate binding site [chemical binding]; other site 910348010222 catalytic site [active] 910348010223 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 910348010224 substrate binding site [chemical binding]; other site 910348010225 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 910348010226 putative RNA binding site [nucleotide binding]; other site 910348010227 16S rRNA methyltransferase B; Provisional; Region: PRK10901 910348010228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348010229 S-adenosylmethionine binding site [chemical binding]; other site 910348010230 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 910348010231 TrkA-N domain; Region: TrkA_N; pfam02254 910348010232 TrkA-C domain; Region: TrkA_C; pfam02080 910348010233 TrkA-N domain; Region: TrkA_N; pfam02254 910348010234 TrkA-C domain; Region: TrkA_C; pfam02080 910348010235 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 910348010236 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 910348010237 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 910348010238 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 910348010239 DNA binding residues [nucleotide binding] 910348010240 dimer interface [polypeptide binding]; other site 910348010241 metal binding site [ion binding]; metal-binding site 910348010242 hypothetical protein; Provisional; Region: PRK10203 910348010243 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 910348010244 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 910348010245 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 910348010246 alphaNTD homodimer interface [polypeptide binding]; other site 910348010247 alphaNTD - beta interaction site [polypeptide binding]; other site 910348010248 alphaNTD - beta' interaction site [polypeptide binding]; other site 910348010249 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 910348010250 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 910348010251 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 910348010252 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 910348010253 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 910348010254 RNA binding surface [nucleotide binding]; other site 910348010255 30S ribosomal protein S11; Validated; Region: PRK05309 910348010256 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 910348010257 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 910348010258 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 910348010259 SecY translocase; Region: SecY; pfam00344 910348010260 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 910348010261 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 910348010262 23S rRNA binding site [nucleotide binding]; other site 910348010263 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 910348010264 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 910348010265 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 910348010266 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 910348010267 23S rRNA interface [nucleotide binding]; other site 910348010268 5S rRNA interface [nucleotide binding]; other site 910348010269 L27 interface [polypeptide binding]; other site 910348010270 L5 interface [polypeptide binding]; other site 910348010271 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 910348010272 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 910348010273 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 910348010274 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 910348010275 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 910348010276 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 910348010277 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 910348010278 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 910348010279 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 910348010280 RNA binding site [nucleotide binding]; other site 910348010281 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 910348010282 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 910348010283 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 910348010284 23S rRNA interface [nucleotide binding]; other site 910348010285 putative translocon interaction site; other site 910348010286 signal recognition particle (SRP54) interaction site; other site 910348010287 L23 interface [polypeptide binding]; other site 910348010288 trigger factor interaction site; other site 910348010289 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 910348010290 23S rRNA interface [nucleotide binding]; other site 910348010291 5S rRNA interface [nucleotide binding]; other site 910348010292 putative antibiotic binding site [chemical binding]; other site 910348010293 L25 interface [polypeptide binding]; other site 910348010294 L27 interface [polypeptide binding]; other site 910348010295 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 910348010296 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 910348010297 G-X-X-G motif; other site 910348010298 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 910348010299 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 910348010300 protein-rRNA interface [nucleotide binding]; other site 910348010301 putative translocon binding site; other site 910348010302 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 910348010303 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 910348010304 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 910348010305 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 910348010306 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 910348010307 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 910348010308 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 910348010309 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 910348010310 protein secretion protein GspB; Provisional; Region: PRK09697 910348010311 AAA domain; Region: AAA_22; pfam13401 910348010312 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 910348010313 Type II secretory pathway, component PulC [Intracellular trafficking and secretion]; Region: PulC; COG3031 910348010314 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 910348010315 putative transposase OrfB; Reviewed; Region: PHA02517 910348010316 HTH-like domain; Region: HTH_21; pfam13276 910348010317 Integrase core domain; Region: rve; pfam00665 910348010318 Integrase core domain; Region: rve_2; pfam13333 910348010319 Transposase; Region: HTH_Tnp_1; cl17663 910348010320 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 910348010321 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 910348010322 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 910348010323 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 910348010324 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 910348010325 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 910348010326 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 910348010327 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 910348010328 Walker A motif; other site 910348010329 ATP binding site [chemical binding]; other site 910348010330 Walker B motif; other site 910348010331 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 910348010332 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 910348010333 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 910348010334 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 910348010335 type II secretion system protein I; Region: gspI; TIGR01707 910348010336 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 910348010337 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 910348010338 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 910348010339 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 910348010340 Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297 910348010341 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 910348010342 GspL periplasmic domain; Region: GspL_C; pfam12693 910348010343 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 910348010344 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 910348010345 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 910348010346 heme binding site [chemical binding]; other site 910348010347 ferroxidase pore; other site 910348010348 ferroxidase diiron center [ion binding]; other site 910348010349 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 910348010350 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 910348010351 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 910348010352 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 910348010353 aromatic chitin/cellulose binding site residues [chemical binding]; other site 910348010354 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 910348010355 active site 910348010356 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 910348010357 Switch II region; other site 910348010358 G4 box; other site 910348010359 G5 box; other site 910348010360 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 910348010361 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 910348010362 Antibiotic Binding Site [chemical binding]; other site 910348010363 elongation factor G; Reviewed; Region: PRK00007 910348010364 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 910348010365 G1 box; other site 910348010366 putative GEF interaction site [polypeptide binding]; other site 910348010367 GTP/Mg2+ binding site [chemical binding]; other site 910348010368 Switch I region; other site 910348010369 G2 box; other site 910348010370 G3 box; other site 910348010371 Switch II region; other site 910348010372 G4 box; other site 910348010373 G5 box; other site 910348010374 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 910348010375 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 910348010376 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 910348010377 30S ribosomal protein S7; Validated; Region: PRK05302 910348010378 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 910348010379 S17 interaction site [polypeptide binding]; other site 910348010380 S8 interaction site; other site 910348010381 16S rRNA interaction site [nucleotide binding]; other site 910348010382 streptomycin interaction site [chemical binding]; other site 910348010383 23S rRNA interaction site [nucleotide binding]; other site 910348010384 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 910348010385 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 910348010386 sulfur relay protein TusC; Validated; Region: PRK00211 910348010387 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 910348010388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 910348010389 YheO-like PAS domain; Region: PAS_6; pfam08348 910348010390 HTH domain; Region: HTH_22; pfam13309 910348010391 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 910348010392 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 910348010393 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 910348010394 SlyX; Region: SlyX; cl01090 910348010395 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 910348010396 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 910348010397 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 910348010398 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 910348010399 TrkA-N domain; Region: TrkA_N; pfam02254 910348010400 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 910348010401 putative hydrolase; Provisional; Region: PRK10985 910348010402 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 910348010403 active site 910348010404 hypothetical protein; Provisional; Region: PRK10738 910348010405 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 910348010406 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 910348010407 ligand binding site [chemical binding]; other site 910348010408 flexible hinge region; other site 910348010409 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 910348010410 putative switch regulator; other site 910348010411 non-specific DNA interactions [nucleotide binding]; other site 910348010412 DNA binding site [nucleotide binding] 910348010413 sequence specific DNA binding site [nucleotide binding]; other site 910348010414 putative cAMP binding site [chemical binding]; other site 910348010415 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 910348010416 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 910348010417 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 910348010418 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 910348010419 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 910348010420 inhibitor-cofactor binding pocket; inhibition site 910348010421 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348010422 catalytic residue [active] 910348010423 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 910348010424 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 910348010425 glutamine binding [chemical binding]; other site 910348010426 catalytic triad [active] 910348010427 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 910348010428 cell filamentation protein Fic; Provisional; Region: PRK10347 910348010429 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 910348010430 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 910348010431 substrate binding site [chemical binding]; other site 910348010432 putative transporter; Provisional; Region: PRK03699 910348010433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348010434 putative substrate translocation pore; other site 910348010435 nitrite reductase subunit NirD; Provisional; Region: PRK14989 910348010436 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 910348010437 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 910348010438 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 910348010439 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 910348010440 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 910348010441 nitrite transporter NirC; Provisional; Region: PRK11562 910348010442 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 910348010443 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 910348010444 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 910348010445 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 910348010446 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 910348010447 active site 910348010448 SAM binding site [chemical binding]; other site 910348010449 homodimer interface [polypeptide binding]; other site 910348010450 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 910348010451 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 910348010452 hypothetical protein; Provisional; Region: PHA02764 910348010453 fructoselysine-6-P-deglycase; Provisional; Region: frlB; PRK11382 910348010454 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 910348010455 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 910348010456 dimer interface [polypeptide binding]; other site 910348010457 active site 910348010458 fructoselysine 3-epimerase; Provisional; Region: PRK09856 910348010459 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 910348010460 AP (apurinic/apyrimidinic) site pocket; other site 910348010461 DNA interaction; other site 910348010462 Metal-binding active site; metal-binding site 910348010463 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 910348010464 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 910348010465 substrate binding site [chemical binding]; other site 910348010466 ATP binding site [chemical binding]; other site 910348010467 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 910348010468 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 910348010469 DNA-binding site [nucleotide binding]; DNA binding site 910348010470 UTRA domain; Region: UTRA; pfam07702 910348010471 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 910348010472 Protein of unknown function; Region: YhfT; pfam10797 910348010473 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 910348010474 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 910348010475 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 910348010476 active site 910348010477 substrate binding pocket [chemical binding]; other site 910348010478 homodimer interaction site [polypeptide binding]; other site 910348010479 putative mutase; Provisional; Region: PRK12383 910348010480 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015 910348010481 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 910348010482 dimer interface [polypeptide binding]; other site 910348010483 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 910348010484 active site 910348010485 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 910348010486 substrate binding site [chemical binding]; other site 910348010487 catalytic residue [active] 910348010488 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 910348010489 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 910348010490 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 910348010491 active site 910348010492 HIGH motif; other site 910348010493 dimer interface [polypeptide binding]; other site 910348010494 KMSKS motif; other site 910348010495 phosphoglycolate phosphatase; Provisional; Region: PRK13222 910348010496 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 910348010497 motif II; other site 910348010498 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 910348010499 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 910348010500 substrate binding site [chemical binding]; other site 910348010501 hexamer interface [polypeptide binding]; other site 910348010502 metal binding site [ion binding]; metal-binding site 910348010503 DNA adenine methylase; Provisional; Region: PRK10904 910348010504 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 910348010505 cell division protein DamX; Validated; Region: PRK10905 910348010506 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 910348010507 active site 910348010508 dimer interface [polypeptide binding]; other site 910348010509 metal binding site [ion binding]; metal-binding site 910348010510 shikimate kinase; Reviewed; Region: aroK; PRK00131 910348010511 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 910348010512 ADP binding site [chemical binding]; other site 910348010513 magnesium binding site [ion binding]; other site 910348010514 putative shikimate binding site; other site 910348010515 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 910348010516 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 910348010517 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 910348010518 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 910348010519 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 910348010520 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 910348010521 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 910348010522 Transglycosylase; Region: Transgly; pfam00912 910348010523 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 910348010524 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 910348010525 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 910348010526 ADP-ribose binding site [chemical binding]; other site 910348010527 dimer interface [polypeptide binding]; other site 910348010528 active site 910348010529 nudix motif; other site 910348010530 metal binding site [ion binding]; metal-binding site 910348010531 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 910348010532 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 910348010533 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 910348010534 motif II; other site 910348010535 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 910348010536 RNA binding surface [nucleotide binding]; other site 910348010537 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 910348010538 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 910348010539 dimerization interface [polypeptide binding]; other site 910348010540 domain crossover interface; other site 910348010541 redox-dependent activation switch; other site 910348010542 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 910348010543 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 910348010544 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 910348010545 active site 910348010546 substrate-binding site [chemical binding]; other site 910348010547 metal-binding site [ion binding] 910348010548 ATP binding site [chemical binding]; other site 910348010549 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 910348010550 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 910348010551 dimerization interface [polypeptide binding]; other site 910348010552 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 910348010553 dimer interface [polypeptide binding]; other site 910348010554 phosphorylation site [posttranslational modification] 910348010555 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348010556 ATP binding site [chemical binding]; other site 910348010557 G-X-G motif; other site 910348010558 osmolarity response regulator; Provisional; Region: ompR; PRK09468 910348010559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348010560 active site 910348010561 phosphorylation site [posttranslational modification] 910348010562 intermolecular recognition site; other site 910348010563 dimerization interface [polypeptide binding]; other site 910348010564 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 910348010565 DNA binding site [nucleotide binding] 910348010566 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 910348010567 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 910348010568 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 910348010569 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 910348010570 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 910348010571 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 910348010572 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 910348010573 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 910348010574 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 910348010575 RNA binding site [nucleotide binding]; other site 910348010576 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 910348010577 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 910348010578 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 910348010579 G1 box; other site 910348010580 GTP/Mg2+ binding site [chemical binding]; other site 910348010581 Switch I region; other site 910348010582 G2 box; other site 910348010583 G3 box; other site 910348010584 Switch II region; other site 910348010585 G4 box; other site 910348010586 G5 box; other site 910348010587 Nucleoside recognition; Region: Gate; pfam07670 910348010588 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 910348010589 Nucleoside recognition; Region: Gate; pfam07670 910348010590 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 910348010591 putative transposase; Provisional; Region: PRK09857 910348010592 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 910348010593 carboxylesterase BioH; Provisional; Region: PRK10349 910348010594 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 910348010595 DNA utilization protein GntX; Provisional; Region: PRK11595 910348010596 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 910348010597 active site 910348010598 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 910348010599 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 910348010600 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 910348010601 high-affinity gluconate transporter; Provisional; Region: PRK14984 910348010602 gluconate transporter; Region: gntP; TIGR00791 910348010603 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 910348010604 4-alpha-glucanotransferase; Region: malQ; TIGR00217 910348010605 maltodextrin phosphorylase; Provisional; Region: PRK14985 910348010606 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 910348010607 homodimer interface [polypeptide binding]; other site 910348010608 active site pocket [active] 910348010609 transcriptional regulator MalT; Provisional; Region: PRK04841 910348010610 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 910348010611 DNA binding residues [nucleotide binding] 910348010612 dimerization interface [polypeptide binding]; other site 910348010613 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 910348010614 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 910348010615 putative active site [active] 910348010616 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 910348010617 hypothetical protein; Reviewed; Region: PRK09588 910348010618 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 910348010619 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 910348010620 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348010621 Walker A motif; other site 910348010622 ATP binding site [chemical binding]; other site 910348010623 Walker B motif; other site 910348010624 arginine finger; other site 910348010625 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 910348010626 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 910348010627 intramembrane serine protease GlpG; Provisional; Region: PRK10907 910348010628 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 910348010629 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 910348010630 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 910348010631 active site residue [active] 910348010632 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 910348010633 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 910348010634 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 910348010635 glycogen phosphorylase; Provisional; Region: PRK14986 910348010636 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 910348010637 homodimer interface [polypeptide binding]; other site 910348010638 active site pocket [active] 910348010639 glycogen synthase; Provisional; Region: glgA; PRK00654 910348010640 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 910348010641 ADP-binding pocket [chemical binding]; other site 910348010642 homodimer interface [polypeptide binding]; other site 910348010643 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 910348010644 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 910348010645 ligand binding site; other site 910348010646 oligomer interface; other site 910348010647 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 910348010648 sulfate 1 binding site; other site 910348010649 glycogen debranching enzyme; Provisional; Region: PRK03705 910348010650 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 910348010651 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 910348010652 active site 910348010653 catalytic site [active] 910348010654 glycogen branching enzyme; Provisional; Region: PRK05402 910348010655 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 910348010656 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 910348010657 active site 910348010658 catalytic site [active] 910348010659 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 910348010660 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 910348010661 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 910348010662 putative antibiotic transporter; Provisional; Region: PRK10739 910348010663 low affinity gluconate transporter; Provisional; Region: PRK10472 910348010664 gluconate transporter; Region: gntP; TIGR00791 910348010665 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 910348010666 Shikimate kinase; Region: SKI; pfam01202 910348010667 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 910348010668 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 910348010669 DNA binding site [nucleotide binding] 910348010670 domain linker motif; other site 910348010671 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 910348010672 putative ligand binding site [chemical binding]; other site 910348010673 putative dimerization interface [polypeptide binding]; other site 910348010674 Pirin-related protein [General function prediction only]; Region: COG1741 910348010675 Pirin; Region: Pirin; pfam02678 910348010676 putative oxidoreductase; Provisional; Region: PRK10206 910348010677 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 910348010678 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 910348010679 putative acetyltransferase YhhY; Provisional; Region: PRK10140 910348010680 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 910348010681 Coenzyme A binding pocket [chemical binding]; other site 910348010682 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 910348010683 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 910348010684 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 910348010685 hypothetical protein; Provisional; Region: PRK10350 910348010686 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 910348010687 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 910348010688 putative active site [active] 910348010689 catalytic site [active] 910348010690 putative metal binding site [ion binding]; other site 910348010691 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 910348010692 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 910348010693 Walker A/P-loop; other site 910348010694 ATP binding site [chemical binding]; other site 910348010695 Q-loop/lid; other site 910348010696 ABC transporter signature motif; other site 910348010697 Walker B; other site 910348010698 D-loop; other site 910348010699 H-loop/switch region; other site 910348010700 TOBE domain; Region: TOBE_2; pfam08402 910348010701 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 910348010702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348010703 dimer interface [polypeptide binding]; other site 910348010704 conserved gate region; other site 910348010705 putative PBP binding loops; other site 910348010706 ABC-ATPase subunit interface; other site 910348010707 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 910348010708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348010709 dimer interface [polypeptide binding]; other site 910348010710 conserved gate region; other site 910348010711 putative PBP binding loops; other site 910348010712 ABC-ATPase subunit interface; other site 910348010713 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 910348010714 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 910348010715 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 910348010716 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 910348010717 Walker A/P-loop; other site 910348010718 ATP binding site [chemical binding]; other site 910348010719 Q-loop/lid; other site 910348010720 ABC transporter signature motif; other site 910348010721 Walker B; other site 910348010722 D-loop; other site 910348010723 H-loop/switch region; other site 910348010724 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 910348010725 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 910348010726 Walker A/P-loop; other site 910348010727 ATP binding site [chemical binding]; other site 910348010728 Q-loop/lid; other site 910348010729 ABC transporter signature motif; other site 910348010730 Walker B; other site 910348010731 D-loop; other site 910348010732 H-loop/switch region; other site 910348010733 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 910348010734 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 910348010735 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 910348010736 TM-ABC transporter signature motif; other site 910348010737 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 910348010738 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 910348010739 TM-ABC transporter signature motif; other site 910348010740 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 910348010741 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 910348010742 dimerization interface [polypeptide binding]; other site 910348010743 ligand binding site [chemical binding]; other site 910348010744 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 910348010745 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 910348010746 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 910348010747 dimerization interface [polypeptide binding]; other site 910348010748 ligand binding site [chemical binding]; other site 910348010749 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 910348010750 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 910348010751 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 910348010752 DNA binding residues [nucleotide binding] 910348010753 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 910348010754 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 910348010755 cell division protein FtsE; Provisional; Region: PRK10908 910348010756 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 910348010757 Walker A/P-loop; other site 910348010758 ATP binding site [chemical binding]; other site 910348010759 Q-loop/lid; other site 910348010760 ABC transporter signature motif; other site 910348010761 Walker B; other site 910348010762 D-loop; other site 910348010763 H-loop/switch region; other site 910348010764 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 910348010765 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 910348010766 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 910348010767 P loop; other site 910348010768 GTP binding site [chemical binding]; other site 910348010769 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 910348010770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348010771 S-adenosylmethionine binding site [chemical binding]; other site 910348010772 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 910348010773 Predicted membrane protein [Function unknown]; Region: COG3714 910348010774 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 910348010775 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 910348010776 metal-binding site [ion binding] 910348010777 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 910348010778 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 910348010779 CPxP motif; other site 910348010780 hypothetical protein; Provisional; Region: PRK11212 910348010781 hypothetical protein; Provisional; Region: PRK11615 910348010782 major facilitator superfamily transporter; Provisional; Region: PRK05122 910348010783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348010784 putative substrate translocation pore; other site 910348010785 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 910348010786 Domain of unknown function DUF20; Region: UPF0118; pfam01594 910348010787 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 910348010788 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 910348010789 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 910348010790 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 910348010791 substrate binding site [chemical binding]; other site 910348010792 nickel transporter permease NikB; Provisional; Region: PRK10352 910348010793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348010794 dimer interface [polypeptide binding]; other site 910348010795 conserved gate region; other site 910348010796 putative PBP binding loops; other site 910348010797 ABC-ATPase subunit interface; other site 910348010798 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 910348010799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348010800 dimer interface [polypeptide binding]; other site 910348010801 conserved gate region; other site 910348010802 putative PBP binding loops; other site 910348010803 ABC-ATPase subunit interface; other site 910348010804 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 910348010805 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 910348010806 Walker A/P-loop; other site 910348010807 ATP binding site [chemical binding]; other site 910348010808 Q-loop/lid; other site 910348010809 ABC transporter signature motif; other site 910348010810 Walker B; other site 910348010811 D-loop; other site 910348010812 H-loop/switch region; other site 910348010813 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 910348010814 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 910348010815 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 910348010816 Walker A/P-loop; other site 910348010817 ATP binding site [chemical binding]; other site 910348010818 Q-loop/lid; other site 910348010819 ABC transporter signature motif; other site 910348010820 Walker B; other site 910348010821 D-loop; other site 910348010822 H-loop/switch region; other site 910348010823 nickel responsive regulator; Provisional; Region: PRK02967 910348010824 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 910348010825 PAAR motif; Region: PAAR_motif; cl15808 910348010826 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 910348010827 RHS Repeat; Region: RHS_repeat; pfam05593 910348010828 RHS Repeat; Region: RHS_repeat; pfam05593 910348010829 RHS Repeat; Region: RHS_repeat; pfam05593 910348010830 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 910348010831 RHS Repeat; Region: RHS_repeat; pfam05593 910348010832 RHS Repeat; Region: RHS_repeat; pfam05593 910348010833 RHS protein; Region: RHS; pfam03527 910348010834 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 910348010835 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 910348010836 putative lyase; Provisional; Region: PRK09687 910348010837 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 910348010838 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 910348010839 Transposase [DNA replication, recombination, and repair]; Region: COG5433 910348010840 Transposase [DNA replication, recombination, and repair]; Region: COG5433 910348010841 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 910348010842 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 910348010843 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 910348010844 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 910348010845 Walker A/P-loop; other site 910348010846 ATP binding site [chemical binding]; other site 910348010847 Q-loop/lid; other site 910348010848 ABC transporter signature motif; other site 910348010849 Walker B; other site 910348010850 D-loop; other site 910348010851 H-loop/switch region; other site 910348010852 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 910348010853 Walker A/P-loop; other site 910348010854 ATP binding site [chemical binding]; other site 910348010855 Q-loop/lid; other site 910348010856 ABC transporter signature motif; other site 910348010857 Walker B; other site 910348010858 D-loop; other site 910348010859 H-loop/switch region; other site 910348010860 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 910348010861 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 910348010862 HlyD family secretion protein; Region: HlyD; pfam00529 910348010863 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 910348010864 HlyD family secretion protein; Region: HlyD_3; pfam13437 910348010865 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 910348010866 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 910348010867 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 910348010868 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 910348010869 dimerization interface [polypeptide binding]; other site 910348010870 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 910348010871 dimer interface [polypeptide binding]; other site 910348010872 phosphorylation site [posttranslational modification] 910348010873 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348010874 ATP binding site [chemical binding]; other site 910348010875 Mg2+ binding site [ion binding]; other site 910348010876 G-X-G motif; other site 910348010877 Response regulator receiver domain; Region: Response_reg; pfam00072 910348010878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348010879 active site 910348010880 phosphorylation site [posttranslational modification] 910348010881 intermolecular recognition site; other site 910348010882 dimerization interface [polypeptide binding]; other site 910348010883 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 910348010884 CopC domain; Region: CopC; pfam04234 910348010885 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 910348010886 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 910348010887 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 910348010888 Multicopper oxidase; Region: Cu-oxidase; pfam00394 910348010889 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 910348010890 Peptidase family M23; Region: Peptidase_M23; pfam01551 910348010891 copper exporting ATPase; Provisional; Region: copA; PRK10671 910348010892 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 910348010893 Transposase; Region: HTH_Tnp_1; pfam01527 910348010894 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 910348010895 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 910348010896 YHS domain; Region: YHS; pfam04945 910348010897 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 910348010898 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 910348010899 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 910348010900 motif II; other site 910348010901 Protein of unknown function, DUF; Region: DUF411; cl01142 910348010902 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 910348010903 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 910348010904 HlyD family secretion protein; Region: HlyD_3; pfam13437 910348010905 periplasmic copper-binding protein; Provisional; Region: PRK09838 910348010906 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 910348010907 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 910348010908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348010909 active site 910348010910 phosphorylation site [posttranslational modification] 910348010911 intermolecular recognition site; other site 910348010912 dimerization interface [polypeptide binding]; other site 910348010913 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 910348010914 DNA binding site [nucleotide binding] 910348010915 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 910348010916 dimerization interface [polypeptide binding]; other site 910348010917 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 910348010918 dimer interface [polypeptide binding]; other site 910348010919 phosphorylation site [posttranslational modification] 910348010920 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348010921 ATP binding site [chemical binding]; other site 910348010922 Mg2+ binding site [ion binding]; other site 910348010923 G-X-G motif; other site 910348010924 Domain of unknown function (DUF305); Region: DUF305; cl17794 910348010925 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 910348010926 Walker A/P-loop; other site 910348010927 ATP binding site [chemical binding]; other site 910348010928 AAA ATPase domain; Region: AAA_15; pfam13175 910348010929 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 910348010930 active site 910348010931 metal binding site [ion binding]; metal-binding site 910348010932 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 910348010933 salt bridge; other site 910348010934 non-specific DNA binding site [nucleotide binding]; other site 910348010935 sequence-specific DNA binding site [nucleotide binding]; other site 910348010936 TniQ; Region: TniQ; pfam06527 910348010937 AAA ATPase domain; Region: AAA_16; pfam13191 910348010938 AAA domain; Region: AAA_22; pfam13401 910348010939 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 910348010940 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 910348010941 Predicted flavoproteins [General function prediction only]; Region: COG2081 910348010942 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 910348010943 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 910348010944 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 910348010945 universal stress protein UspB; Provisional; Region: PRK04960 910348010946 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 910348010947 Ligand Binding Site [chemical binding]; other site 910348010948 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 910348010949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348010950 POT family; Region: PTR2; pfam00854 910348010951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348010952 S-adenosylmethionine binding site [chemical binding]; other site 910348010953 oligopeptidase A; Provisional; Region: PRK10911 910348010954 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 910348010955 active site 910348010956 Zn binding site [ion binding]; other site 910348010957 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 910348010958 glutathione reductase; Validated; Region: PRK06116 910348010959 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 910348010960 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 910348010961 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 910348010962 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 910348010963 dimerization interface [polypeptide binding]; other site 910348010964 putative DNA binding site [nucleotide binding]; other site 910348010965 putative Zn2+ binding site [ion binding]; other site 910348010966 arsenical pump membrane protein; Provisional; Region: PRK15445 910348010967 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 910348010968 transmembrane helices; other site 910348010969 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 910348010970 ArsC family; Region: ArsC; pfam03960 910348010971 catalytic residues [active] 910348010972 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 910348010973 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 910348010974 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 910348010975 DNA binding residues [nucleotide binding] 910348010976 dimerization interface [polypeptide binding]; other site 910348010977 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 910348010978 MgtC family; Region: MgtC; pfam02308 910348010979 acid-resistance protein; Provisional; Region: hdeB; PRK11566 910348010980 acid-resistance protein; Provisional; Region: PRK10208 910348010981 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 910348010982 acid-resistance membrane protein; Provisional; Region: PRK10209 910348010983 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 910348010984 pyruvate kinase; Provisional; Region: PRK05826 910348010985 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 910348010986 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 910348010987 HlyD family secretion protein; Region: HlyD_3; pfam13437 910348010988 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 910348010989 Protein export membrane protein; Region: SecD_SecF; cl14618 910348010990 transcriptional regulator YdeO; Provisional; Region: PRK09940 910348010991 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348010992 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 910348010993 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348010994 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 910348010995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348010996 catalytic residue [active] 910348010997 Haem-binding domain; Region: Haem_bd; pfam14376 910348010998 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 910348010999 trehalase; Provisional; Region: treF; PRK13270 910348011000 Trehalase; Region: Trehalase; pfam01204 910348011001 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 910348011002 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 910348011003 DNA binding residues [nucleotide binding] 910348011004 dimerization interface [polypeptide binding]; other site 910348011005 Transcriptional regulator [Transcription]; Region: LysR; COG0583 910348011006 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348011007 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 910348011008 putative effector binding pocket; other site 910348011009 putative dimerization interface [polypeptide binding]; other site 910348011010 inner membrane protein YhjD; Region: TIGR00766 910348011011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348011012 metabolite-proton symporter; Region: 2A0106; TIGR00883 910348011013 putative substrate translocation pore; other site 910348011014 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 910348011015 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 910348011016 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 910348011017 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 910348011018 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 910348011019 substrate binding site [chemical binding]; other site 910348011020 ATP binding site [chemical binding]; other site 910348011021 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 910348011022 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 910348011023 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 910348011024 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 910348011025 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 910348011026 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 910348011027 metal binding site [ion binding]; metal-binding site 910348011028 active site 910348011029 I-site; other site 910348011030 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 910348011031 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 910348011032 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 910348011033 binding surface 910348011034 TPR motif; other site 910348011035 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 910348011036 binding surface 910348011037 TPR motif; other site 910348011038 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 910348011039 endo-1,4-D-glucanase; Provisional; Region: PRK11097 910348011040 cellulose synthase regulator protein; Provisional; Region: PRK11114 910348011041 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 910348011042 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 910348011043 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 910348011044 DXD motif; other site 910348011045 PilZ domain; Region: PilZ; pfam07238 910348011046 cell division protein; Provisional; Region: PRK10037 910348011047 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 910348011048 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 910348011049 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 910348011050 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 910348011051 serine transporter; Region: stp; TIGR00814 910348011052 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 910348011053 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 910348011054 Walker A/P-loop; other site 910348011055 ATP binding site [chemical binding]; other site 910348011056 Q-loop/lid; other site 910348011057 ABC transporter signature motif; other site 910348011058 Walker B; other site 910348011059 D-loop; other site 910348011060 H-loop/switch region; other site 910348011061 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 910348011062 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 910348011063 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 910348011064 Walker A/P-loop; other site 910348011065 ATP binding site [chemical binding]; other site 910348011066 Q-loop/lid; other site 910348011067 ABC transporter signature motif; other site 910348011068 Walker B; other site 910348011069 D-loop; other site 910348011070 H-loop/switch region; other site 910348011071 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 910348011072 dipeptide transporter; Provisional; Region: PRK10913 910348011073 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 910348011074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348011075 dimer interface [polypeptide binding]; other site 910348011076 conserved gate region; other site 910348011077 putative PBP binding loops; other site 910348011078 ABC-ATPase subunit interface; other site 910348011079 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 910348011080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348011081 dimer interface [polypeptide binding]; other site 910348011082 conserved gate region; other site 910348011083 putative PBP binding loops; other site 910348011084 ABC-ATPase subunit interface; other site 910348011085 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 910348011086 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 910348011087 peptide binding site [polypeptide binding]; other site 910348011088 phosphoethanolamine transferase; Provisional; Region: PRK11560 910348011089 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 910348011090 Sulfatase; Region: Sulfatase; pfam00884 910348011091 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 910348011092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348011093 putative substrate translocation pore; other site 910348011094 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 910348011095 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 910348011096 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 910348011097 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 910348011098 Coenzyme A binding pocket [chemical binding]; other site 910348011099 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 910348011100 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 910348011101 molybdopterin cofactor binding site [chemical binding]; other site 910348011102 substrate binding site [chemical binding]; other site 910348011103 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 910348011104 molybdopterin cofactor binding site; other site 910348011105 putative outer membrane lipoprotein; Provisional; Region: PRK10510 910348011106 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 910348011107 ligand binding site [chemical binding]; other site 910348011108 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 910348011109 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 910348011110 dimerization interface [polypeptide binding]; other site 910348011111 ligand binding site [chemical binding]; other site 910348011112 NADP binding site [chemical binding]; other site 910348011113 catalytic site [active] 910348011114 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 910348011115 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 910348011116 DNA-binding site [nucleotide binding]; DNA binding site 910348011117 RNA-binding motif; other site 910348011118 small toxic polypeptide; Provisional; Region: PRK09759 910348011119 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 910348011120 Helix-turn-helix domain; Region: HTH_28; pfam13518 910348011121 Helix-turn-helix domain; Region: HTH_28; pfam13518 910348011122 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 910348011123 DALR anticodon binding domain; Region: DALR_1; pfam05746 910348011124 anticodon binding site; other site 910348011125 tRNA binding surface [nucleotide binding]; other site 910348011126 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 910348011127 dimer interface [polypeptide binding]; other site 910348011128 motif 1; other site 910348011129 active site 910348011130 motif 2; other site 910348011131 motif 3; other site 910348011132 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 910348011133 Acyltransferase family; Region: Acyl_transf_3; pfam01757 910348011134 hypothetical protein; Provisional; Region: PRK11383 910348011135 yiaA/B two helix domain; Region: YiaAB; pfam05360 910348011136 yiaA/B two helix domain; Region: YiaAB; pfam05360 910348011137 hypothetical protein; Provisional; Region: PRK11403 910348011138 yiaA/B two helix domain; Region: YiaAB; pfam05360 910348011139 xylulokinase; Provisional; Region: PRK15027 910348011140 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 910348011141 N- and C-terminal domain interface [polypeptide binding]; other site 910348011142 active site 910348011143 MgATP binding site [chemical binding]; other site 910348011144 catalytic site [active] 910348011145 metal binding site [ion binding]; metal-binding site 910348011146 xylulose binding site [chemical binding]; other site 910348011147 homodimer interface [polypeptide binding]; other site 910348011148 xylose isomerase; Provisional; Region: PRK05474 910348011149 xylose isomerase; Region: xylose_isom_A; TIGR02630 910348011150 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 910348011151 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 910348011152 putative ligand binding site [chemical binding]; other site 910348011153 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 910348011154 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 910348011155 Walker A/P-loop; other site 910348011156 ATP binding site [chemical binding]; other site 910348011157 Q-loop/lid; other site 910348011158 ABC transporter signature motif; other site 910348011159 Walker B; other site 910348011160 D-loop; other site 910348011161 H-loop/switch region; other site 910348011162 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 910348011163 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 910348011164 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 910348011165 TM-ABC transporter signature motif; other site 910348011166 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 910348011167 putative dimerization interface [polypeptide binding]; other site 910348011168 Transcriptional regulators [Transcription]; Region: PurR; COG1609 910348011169 putative ligand binding site [chemical binding]; other site 910348011170 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348011171 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 910348011172 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348011173 hypothetical protein; Provisional; Region: PRK10356 910348011174 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 910348011175 alpha-amylase; Reviewed; Region: malS; PRK09505 910348011176 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 910348011177 active site 910348011178 catalytic site [active] 910348011179 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 910348011180 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 910348011181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348011182 homodimer interface [polypeptide binding]; other site 910348011183 catalytic residue [active] 910348011184 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 910348011185 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 910348011186 Transcriptional regulator [Transcription]; Region: IclR; COG1414 910348011187 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 910348011188 Bacterial transcriptional regulator; Region: IclR; pfam01614 910348011189 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 910348011190 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 910348011191 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 910348011192 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 910348011193 DctM-like transporters; Region: DctM; pfam06808 910348011194 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 910348011195 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 910348011196 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 910348011197 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 910348011198 putative N- and C-terminal domain interface [polypeptide binding]; other site 910348011199 putative active site [active] 910348011200 MgATP binding site [chemical binding]; other site 910348011201 catalytic site [active] 910348011202 metal binding site [ion binding]; metal-binding site 910348011203 putative xylulose binding site [chemical binding]; other site 910348011204 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 910348011205 active site 910348011206 dimer interface [polypeptide binding]; other site 910348011207 magnesium binding site [ion binding]; other site 910348011208 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 910348011209 AP (apurinic/apyrimidinic) site pocket; other site 910348011210 DNA interaction; other site 910348011211 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 910348011212 Metal-binding active site; metal-binding site 910348011213 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 910348011214 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 910348011215 intersubunit interface [polypeptide binding]; other site 910348011216 active site 910348011217 Zn2+ binding site [ion binding]; other site 910348011218 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 910348011219 Transcriptional regulator [Transcription]; Region: LysR; COG0583 910348011220 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348011221 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 910348011222 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 910348011223 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 910348011224 HlyD family secretion protein; Region: HlyD_3; pfam13437 910348011225 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 910348011226 FlxA-like protein; Region: FlxA; pfam14282 910348011227 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 910348011228 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 910348011229 NAD(P) binding site [chemical binding]; other site 910348011230 catalytic residues [active] 910348011231 putative alcohol dehydrogenase; Provisional; Region: PRK09860 910348011232 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 910348011233 dimer interface [polypeptide binding]; other site 910348011234 active site 910348011235 metal binding site [ion binding]; metal-binding site 910348011236 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 910348011237 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 910348011238 G1 box; other site 910348011239 putative GEF interaction site [polypeptide binding]; other site 910348011240 GTP/Mg2+ binding site [chemical binding]; other site 910348011241 Switch I region; other site 910348011242 G2 box; other site 910348011243 G3 box; other site 910348011244 Switch II region; other site 910348011245 G4 box; other site 910348011246 G5 box; other site 910348011247 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 910348011248 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 910348011249 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 910348011250 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 910348011251 selenocysteine synthase; Provisional; Region: PRK04311 910348011252 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 910348011253 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 910348011254 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 910348011255 catalytic residue [active] 910348011256 putative glutathione S-transferase; Provisional; Region: PRK10357 910348011257 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 910348011258 putative C-terminal domain interface [polypeptide binding]; other site 910348011259 putative GSH binding site (G-site) [chemical binding]; other site 910348011260 putative dimer interface [polypeptide binding]; other site 910348011261 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 910348011262 dimer interface [polypeptide binding]; other site 910348011263 N-terminal domain interface [polypeptide binding]; other site 910348011264 putative substrate binding pocket (H-site) [chemical binding]; other site 910348011265 putative lyase; Provisional; Region: PRK09687 910348011266 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 910348011267 RHS protein; Region: RHS; pfam03527 910348011268 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 910348011269 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 910348011270 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 910348011271 HlyD family secretion protein; Region: HlyD_3; pfam13437 910348011272 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 910348011273 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 910348011274 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 910348011275 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 910348011276 active site 910348011277 P-loop; other site 910348011278 phosphorylation site [posttranslational modification] 910348011279 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 910348011280 active site 910348011281 phosphorylation site [posttranslational modification] 910348011282 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 910348011283 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 910348011284 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 910348011285 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 910348011286 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 910348011287 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 910348011288 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 910348011289 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 910348011290 trimer interface [polypeptide binding]; other site 910348011291 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 910348011292 trimer interface [polypeptide binding]; other site 910348011293 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 910348011294 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 910348011295 trimer interface [polypeptide binding]; other site 910348011296 Haemagglutinin; Region: HIM; pfam05662 910348011297 Haemagglutinin; Region: HIM; pfam05662 910348011298 YadA-like C-terminal region; Region: YadA; pfam03895 910348011299 L-lactate permease; Provisional; Region: PRK10420 910348011300 glycolate transporter; Provisional; Region: PRK09695 910348011301 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 910348011302 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 910348011303 DNA-binding site [nucleotide binding]; DNA binding site 910348011304 FCD domain; Region: FCD; pfam07729 910348011305 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 910348011306 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 910348011307 phosphate binding site [ion binding]; other site 910348011308 putative rRNA methylase; Provisional; Region: PRK10358 910348011309 serine acetyltransferase; Provisional; Region: cysE; PRK11132 910348011310 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 910348011311 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 910348011312 trimer interface [polypeptide binding]; other site 910348011313 active site 910348011314 substrate binding site [chemical binding]; other site 910348011315 CoA binding site [chemical binding]; other site 910348011316 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 910348011317 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 910348011318 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 910348011319 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 910348011320 SecA binding site; other site 910348011321 Preprotein binding site; other site 910348011322 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 910348011323 GSH binding site [chemical binding]; other site 910348011324 catalytic residues [active] 910348011325 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 910348011326 active site residue [active] 910348011327 phosphoglyceromutase; Provisional; Region: PRK05434 910348011328 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 910348011329 AmiB activator; Provisional; Region: PRK11637 910348011330 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 910348011331 Peptidase family M23; Region: Peptidase_M23; pfam01551 910348011332 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 910348011333 putative active site [active] 910348011334 NodB motif; other site 910348011335 putative glycosyl transferase; Provisional; Region: PRK10073 910348011336 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 910348011337 active site 910348011338 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 910348011339 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 910348011340 NAD(P) binding site [chemical binding]; other site 910348011341 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 910348011342 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 910348011343 substrate-cofactor binding pocket; other site 910348011344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348011345 catalytic residue [active] 910348011346 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 910348011347 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 910348011348 NADP binding site [chemical binding]; other site 910348011349 homopentamer interface [polypeptide binding]; other site 910348011350 substrate binding site [chemical binding]; other site 910348011351 active site 910348011352 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 910348011353 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 910348011354 putative active site [active] 910348011355 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 910348011356 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 910348011357 putative active site [active] 910348011358 O-Antigen ligase; Region: Wzy_C; pfam04932 910348011359 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 910348011360 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 910348011361 active site 910348011362 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 910348011363 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 910348011364 Ligand binding site; other site 910348011365 metal-binding site 910348011366 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 910348011367 potential frameshift: common BLAST hit: gi|218556189|ref|YP_002389102.1| lipopolysaccharide core biosynthesis protein 910348011368 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; cl17526 910348011369 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; cl17526 910348011370 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 910348011371 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 910348011372 Ligand binding site; other site 910348011373 metal-binding site 910348011374 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 910348011375 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 910348011376 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 910348011377 Ligand binding site; other site 910348011378 metal-binding site 910348011379 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 910348011380 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 910348011381 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 910348011382 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 910348011383 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 910348011384 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 910348011385 putative active site [active] 910348011386 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 910348011387 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 910348011388 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 910348011389 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 910348011390 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 910348011391 active site 910348011392 (T/H)XGH motif; other site 910348011393 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 910348011394 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 910348011395 DNA binding site [nucleotide binding] 910348011396 catalytic residue [active] 910348011397 H2TH interface [polypeptide binding]; other site 910348011398 putative catalytic residues [active] 910348011399 turnover-facilitating residue; other site 910348011400 intercalation triad [nucleotide binding]; other site 910348011401 8OG recognition residue [nucleotide binding]; other site 910348011402 putative reading head residues; other site 910348011403 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 910348011404 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 910348011405 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 910348011406 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 910348011407 hypothetical protein; Reviewed; Region: PRK00024 910348011408 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 910348011409 MPN+ (JAMM) motif; other site 910348011410 Zinc-binding site [ion binding]; other site 910348011411 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 910348011412 Flavoprotein; Region: Flavoprotein; pfam02441 910348011413 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 910348011414 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 910348011415 trimer interface [polypeptide binding]; other site 910348011416 active site 910348011417 division inhibitor protein; Provisional; Region: slmA; PRK09480 910348011418 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 910348011419 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 910348011420 active site 910348011421 ribonuclease PH; Reviewed; Region: rph; PRK00173 910348011422 Ribonuclease PH; Region: RNase_PH_bact; cd11362 910348011423 hexamer interface [polypeptide binding]; other site 910348011424 active site 910348011425 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 910348011426 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 910348011427 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 910348011428 BRO family, N-terminal domain; Region: Bro-N; pfam02498 910348011429 Predicted membrane protein [Function unknown]; Region: COG2860 910348011430 UPF0126 domain; Region: UPF0126; pfam03458 910348011431 UPF0126 domain; Region: UPF0126; pfam03458 910348011432 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 910348011433 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 910348011434 nucleotide binding pocket [chemical binding]; other site 910348011435 K-X-D-G motif; other site 910348011436 catalytic site [active] 910348011437 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 910348011438 putative transposase OrfB; Reviewed; Region: PHA02517 910348011439 HTH-like domain; Region: HTH_21; pfam13276 910348011440 Integrase core domain; Region: rve; pfam00665 910348011441 Integrase core domain; Region: rve_3; pfam13683 910348011442 Transposase; Region: HTH_Tnp_1; cl17663 910348011443 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 910348011444 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 910348011445 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 910348011446 catalytic site [active] 910348011447 G-X2-G-X-G-K; other site 910348011448 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 910348011449 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 910348011450 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 910348011451 Zn2+ binding site [ion binding]; other site 910348011452 Mg2+ binding site [ion binding]; other site 910348011453 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 910348011454 synthetase active site [active] 910348011455 NTP binding site [chemical binding]; other site 910348011456 metal binding site [ion binding]; metal-binding site 910348011457 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 910348011458 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 910348011459 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 910348011460 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 910348011461 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 910348011462 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 910348011463 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 910348011464 generic binding surface II; other site 910348011465 ssDNA binding site; other site 910348011466 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 910348011467 ATP binding site [chemical binding]; other site 910348011468 putative Mg++ binding site [ion binding]; other site 910348011469 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 910348011470 nucleotide binding region [chemical binding]; other site 910348011471 ATP-binding site [chemical binding]; other site 910348011472 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 910348011473 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 910348011474 AsmA family; Region: AsmA; pfam05170 910348011475 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 910348011476 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 910348011477 putative alpha-glucosidase; Provisional; Region: PRK10658 910348011478 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 910348011479 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 910348011480 active site 910348011481 homotrimer interface [polypeptide binding]; other site 910348011482 catalytic site [active] 910348011483 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 910348011484 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 910348011485 putative transporter; Provisional; Region: PRK11462 910348011486 integrase; Provisional; Region: PRK09692 910348011487 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 910348011488 active site 910348011489 Int/Topo IB signature motif; other site 910348011490 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348011491 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 910348011492 Integrase core domain; Region: rve; pfam00665 910348011493 Integrase core domain; Region: rve_2; pfam13333 910348011494 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 910348011495 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 910348011496 putative active site [active] 910348011497 putative NTP binding site [chemical binding]; other site 910348011498 putative nucleic acid binding site [nucleotide binding]; other site 910348011499 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 910348011500 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 910348011501 Helix-turn-helix domain; Region: HTH_38; pfam13936 910348011502 Integrase core domain; Region: rve; pfam00665 910348011503 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 910348011504 Transposase; Region: HTH_Tnp_1; pfam01527 910348011505 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 910348011506 sugar efflux transporter; Region: 2A0120; TIGR00899 910348011507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348011508 putative substrate translocation pore; other site 910348011509 EamA-like transporter family; Region: EamA; pfam00892 910348011510 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 910348011511 EamA-like transporter family; Region: EamA; pfam00892 910348011512 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 910348011513 lipoprotein, YaeC family; Region: TIGR00363 910348011514 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 910348011515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348011516 putative substrate translocation pore; other site 910348011517 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 910348011518 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 910348011519 cryptic adenine deaminase; Provisional; Region: PRK10027 910348011520 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 910348011521 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 910348011522 active site 910348011523 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 910348011524 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 910348011525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348011526 putative substrate translocation pore; other site 910348011527 regulatory protein UhpC; Provisional; Region: PRK11663 910348011528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348011529 putative substrate translocation pore; other site 910348011530 sensory histidine kinase UhpB; Provisional; Region: PRK11644 910348011531 MASE1; Region: MASE1; pfam05231 910348011532 Histidine kinase; Region: HisKA_3; pfam07730 910348011533 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 910348011534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348011535 active site 910348011536 phosphorylation site [posttranslational modification] 910348011537 intermolecular recognition site; other site 910348011538 dimerization interface [polypeptide binding]; other site 910348011539 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 910348011540 DNA binding residues [nucleotide binding] 910348011541 dimerization interface [polypeptide binding]; other site 910348011542 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 910348011543 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 910348011544 putative valine binding site [chemical binding]; other site 910348011545 dimer interface [polypeptide binding]; other site 910348011546 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 910348011547 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 910348011548 PYR/PP interface [polypeptide binding]; other site 910348011549 dimer interface [polypeptide binding]; other site 910348011550 TPP binding site [chemical binding]; other site 910348011551 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 910348011552 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 910348011553 TPP-binding site [chemical binding]; other site 910348011554 dimer interface [polypeptide binding]; other site 910348011555 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 910348011556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348011557 putative substrate translocation pore; other site 910348011558 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 910348011559 Domain of unknown function (DUF202); Region: DUF202; pfam02656 910348011560 Predicted membrane protein [Function unknown]; Region: COG2149 910348011561 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 910348011562 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 910348011563 NAD(P) binding site [chemical binding]; other site 910348011564 LDH/MDH dimer interface [polypeptide binding]; other site 910348011565 substrate binding site [chemical binding]; other site 910348011566 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 910348011567 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 910348011568 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 910348011569 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 910348011570 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 910348011571 active site turn [active] 910348011572 phosphorylation site [posttranslational modification] 910348011573 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 910348011574 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 910348011575 DNA-binding site [nucleotide binding]; DNA binding site 910348011576 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 910348011577 putative transporter; Validated; Region: PRK03818 910348011578 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 910348011579 TrkA-C domain; Region: TrkA_C; pfam02080 910348011580 TrkA-C domain; Region: TrkA_C; pfam02080 910348011581 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 910348011582 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 910348011583 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 910348011584 putative dimer interface [polypeptide binding]; other site 910348011585 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 910348011586 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 910348011587 putative dimer interface [polypeptide binding]; other site 910348011588 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 910348011589 putative oxidoreductase; Provisional; Region: PRK11445 910348011590 hypothetical protein; Provisional; Region: PRK07236 910348011591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348011592 D-galactonate transporter; Region: 2A0114; TIGR00893 910348011593 putative substrate translocation pore; other site 910348011594 galactonate dehydratase; Provisional; Region: PRK14017 910348011595 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 910348011596 putative active site pocket [active] 910348011597 putative metal binding site [ion binding]; other site 910348011598 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 910348011599 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 910348011600 active site 910348011601 intersubunit interface [polypeptide binding]; other site 910348011602 catalytic residue [active] 910348011603 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 910348011604 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 910348011605 Transcriptional regulators [Transcription]; Region: FadR; COG2186 910348011606 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 910348011607 DNA-binding site [nucleotide binding]; DNA binding site 910348011608 FCD domain; Region: FCD; pfam07729 910348011609 hypothetical protein; Provisional; Region: PRK10215 910348011610 sugar phosphate phosphatase; Provisional; Region: PRK10513 910348011611 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 910348011612 active site 910348011613 motif I; other site 910348011614 motif II; other site 910348011615 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 910348011616 hypothetical protein; Provisional; Region: PRK11426 910348011617 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 910348011618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348011619 Mg2+ binding site [ion binding]; other site 910348011620 G-X-G motif; other site 910348011621 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 910348011622 anchoring element; other site 910348011623 dimer interface [polypeptide binding]; other site 910348011624 ATP binding site [chemical binding]; other site 910348011625 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 910348011626 active site 910348011627 putative metal-binding site [ion binding]; other site 910348011628 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 910348011629 recF protein; Region: recf; TIGR00611 910348011630 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 910348011631 Walker A/P-loop; other site 910348011632 ATP binding site [chemical binding]; other site 910348011633 Q-loop/lid; other site 910348011634 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 910348011635 ABC transporter signature motif; other site 910348011636 Walker B; other site 910348011637 D-loop; other site 910348011638 H-loop/switch region; other site 910348011639 DNA polymerase III subunit beta; Validated; Region: PRK05643 910348011640 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 910348011641 putative DNA binding surface [nucleotide binding]; other site 910348011642 dimer interface [polypeptide binding]; other site 910348011643 beta-clamp/clamp loader binding surface; other site 910348011644 beta-clamp/translesion DNA polymerase binding surface; other site 910348011645 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 910348011646 DnaA N-terminal domain; Region: DnaA_N; pfam11638 910348011647 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348011648 Walker A motif; other site 910348011649 ATP binding site [chemical binding]; other site 910348011650 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 910348011651 Walker B motif; other site 910348011652 arginine finger; other site 910348011653 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 910348011654 DnaA box-binding interface [nucleotide binding]; other site 910348011655 Ribonuclease P; Region: Ribonuclease_P; cl00457 910348011656 membrane protein insertase; Provisional; Region: PRK01318 910348011657 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 910348011658 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 910348011659 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 910348011660 trmE is a tRNA modification GTPase; Region: trmE; cd04164 910348011661 G1 box; other site 910348011662 GTP/Mg2+ binding site [chemical binding]; other site 910348011663 Switch I region; other site 910348011664 G2 box; other site 910348011665 Switch II region; other site 910348011666 G3 box; other site 910348011667 G4 box; other site 910348011668 G5 box; other site 910348011669 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 910348011670 Tryptophanese operon leader peptide; Region: Tna_leader; pfam08053 910348011671 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 910348011672 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 910348011673 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 910348011674 catalytic residue [active] 910348011675 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 910348011676 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 910348011677 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 910348011678 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 910348011679 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 910348011680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348011681 putative substrate translocation pore; other site 910348011682 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 910348011683 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348011684 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 910348011685 substrate binding pocket [chemical binding]; other site 910348011686 dimerization interface [polypeptide binding]; other site 910348011687 Predicted flavoprotein [General function prediction only]; Region: COG0431 910348011688 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 910348011689 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 910348011690 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 910348011691 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 910348011692 active site 910348011693 motif I; other site 910348011694 motif II; other site 910348011695 Uncharacterized protein family (UPF0167); Region: UPF0167; cl01252 910348011696 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 910348011697 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 910348011698 active site 910348011699 trimer interface [polypeptide binding]; other site 910348011700 allosteric site; other site 910348011701 active site lid [active] 910348011702 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 910348011703 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 910348011704 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 910348011705 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 910348011706 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 910348011707 beta-galactosidase; Region: BGL; TIGR03356 910348011708 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 910348011709 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 910348011710 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 910348011711 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 910348011712 HPr interaction site; other site 910348011713 glycerol kinase (GK) interaction site [polypeptide binding]; other site 910348011714 active site 910348011715 phosphorylation site [posttranslational modification] 910348011716 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348011717 transcriptional antiterminator BglG; Provisional; Region: PRK09772 910348011718 CAT RNA binding domain; Region: CAT_RBD; pfam03123 910348011719 PRD domain; Region: PRD; pfam00874 910348011720 PRD domain; Region: PRD; pfam00874 910348011721 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348011722 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 910348011723 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 910348011724 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 910348011725 transcriptional regulator PhoU; Provisional; Region: PRK11115 910348011726 PhoU domain; Region: PhoU; pfam01895 910348011727 PhoU domain; Region: PhoU; pfam01895 910348011728 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 910348011729 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 910348011730 Walker A/P-loop; other site 910348011731 ATP binding site [chemical binding]; other site 910348011732 Q-loop/lid; other site 910348011733 ABC transporter signature motif; other site 910348011734 Walker B; other site 910348011735 D-loop; other site 910348011736 H-loop/switch region; other site 910348011737 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 910348011738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348011739 dimer interface [polypeptide binding]; other site 910348011740 conserved gate region; other site 910348011741 putative PBP binding loops; other site 910348011742 ABC-ATPase subunit interface; other site 910348011743 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 910348011744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348011745 dimer interface [polypeptide binding]; other site 910348011746 conserved gate region; other site 910348011747 putative PBP binding loops; other site 910348011748 ABC-ATPase subunit interface; other site 910348011749 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 910348011750 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 910348011751 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 910348011752 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 910348011753 dimer interface [polypeptide binding]; other site 910348011754 active site 910348011755 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 910348011756 dimer interface [polypeptide binding]; other site 910348011757 active site 910348011758 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 910348011759 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 910348011760 Substrate binding site; other site 910348011761 Mg++ binding site; other site 910348011762 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 910348011763 active site 910348011764 substrate binding site [chemical binding]; other site 910348011765 CoA binding site [chemical binding]; other site 910348011766 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 910348011767 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 910348011768 gamma subunit interface [polypeptide binding]; other site 910348011769 epsilon subunit interface [polypeptide binding]; other site 910348011770 LBP interface [polypeptide binding]; other site 910348011771 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 910348011772 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 910348011773 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 910348011774 alpha subunit interaction interface [polypeptide binding]; other site 910348011775 Walker A motif; other site 910348011776 ATP binding site [chemical binding]; other site 910348011777 Walker B motif; other site 910348011778 inhibitor binding site; inhibition site 910348011779 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 910348011780 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 910348011781 core domain interface [polypeptide binding]; other site 910348011782 delta subunit interface [polypeptide binding]; other site 910348011783 epsilon subunit interface [polypeptide binding]; other site 910348011784 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 910348011785 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 910348011786 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 910348011787 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 910348011788 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 910348011789 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 910348011790 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 910348011791 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 910348011792 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 910348011793 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348011794 S-adenosylmethionine binding site [chemical binding]; other site 910348011795 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 910348011796 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 910348011797 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 910348011798 FMN-binding protein MioC; Provisional; Region: PRK09004 910348011799 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 910348011800 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 910348011801 putative DNA binding site [nucleotide binding]; other site 910348011802 putative Zn2+ binding site [ion binding]; other site 910348011803 AsnC family; Region: AsnC_trans_reg; pfam01037 910348011804 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 910348011805 dimer interface [polypeptide binding]; other site 910348011806 active site 910348011807 hypothetical protein; Provisional; Region: yieM; PRK10997 910348011808 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 910348011809 metal ion-dependent adhesion site (MIDAS); other site 910348011810 regulatory ATPase RavA; Provisional; Region: PRK13531 910348011811 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348011812 Walker A motif; other site 910348011813 ATP binding site [chemical binding]; other site 910348011814 Walker B motif; other site 910348011815 arginine finger; other site 910348011816 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 910348011817 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 910348011818 potassium uptake protein; Region: kup; TIGR00794 910348011819 D-ribose pyranase; Provisional; Region: PRK11797 910348011820 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 910348011821 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 910348011822 Walker A/P-loop; other site 910348011823 ATP binding site [chemical binding]; other site 910348011824 Q-loop/lid; other site 910348011825 ABC transporter signature motif; other site 910348011826 Walker B; other site 910348011827 D-loop; other site 910348011828 H-loop/switch region; other site 910348011829 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 910348011830 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 910348011831 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 910348011832 TM-ABC transporter signature motif; other site 910348011833 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 910348011834 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 910348011835 ligand binding site [chemical binding]; other site 910348011836 dimerization interface [polypeptide binding]; other site 910348011837 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 910348011838 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 910348011839 substrate binding site [chemical binding]; other site 910348011840 dimer interface [polypeptide binding]; other site 910348011841 ATP binding site [chemical binding]; other site 910348011842 transcriptional repressor RbsR; Provisional; Region: PRK10423 910348011843 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 910348011844 DNA binding site [nucleotide binding] 910348011845 domain linker motif; other site 910348011846 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 910348011847 dimerization interface [polypeptide binding]; other site 910348011848 ligand binding site [chemical binding]; other site 910348011849 putative transporter; Provisional; Region: PRK10504 910348011850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348011851 putative substrate translocation pore; other site 910348011852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348011853 Transcriptional regulators [Transcription]; Region: FadR; COG2186 910348011854 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 910348011855 DNA-binding site [nucleotide binding]; DNA binding site 910348011856 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 910348011857 LysR substrate binding domain; Region: LysR_substrate; pfam03466 910348011858 dimerization interface [polypeptide binding]; other site 910348011859 hypothetical protein; Provisional; Region: PRK11027 910348011860 putative ATP-dependent protease; Provisional; Region: PRK09862 910348011861 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 910348011862 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348011863 Walker A motif; other site 910348011864 ATP binding site [chemical binding]; other site 910348011865 Walker B motif; other site 910348011866 arginine finger; other site 910348011867 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 910348011868 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 910348011869 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 910348011870 PYR/PP interface [polypeptide binding]; other site 910348011871 dimer interface [polypeptide binding]; other site 910348011872 TPP binding site [chemical binding]; other site 910348011873 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 910348011874 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 910348011875 TPP-binding site [chemical binding]; other site 910348011876 dimer interface [polypeptide binding]; other site 910348011877 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 910348011878 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 910348011879 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 910348011880 homodimer interface [polypeptide binding]; other site 910348011881 substrate-cofactor binding pocket; other site 910348011882 catalytic residue [active] 910348011883 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 910348011884 threonine dehydratase; Reviewed; Region: PRK09224 910348011885 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 910348011886 tetramer interface [polypeptide binding]; other site 910348011887 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348011888 catalytic residue [active] 910348011889 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 910348011890 putative Ile/Val binding site [chemical binding]; other site 910348011891 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 910348011892 putative Ile/Val binding site [chemical binding]; other site 910348011893 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348011894 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 910348011895 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 910348011896 putative dimerization interface [polypeptide binding]; other site 910348011897 ketol-acid reductoisomerase; Validated; Region: PRK05225 910348011898 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 910348011899 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 910348011900 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 910348011901 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 910348011902 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 910348011903 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 910348011904 Part of AAA domain; Region: AAA_19; pfam13245 910348011905 Family description; Region: UvrD_C_2; pfam13538 910348011906 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 910348011907 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 910348011908 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 910348011909 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 910348011910 ATP binding site [chemical binding]; other site 910348011911 Mg++ binding site [ion binding]; other site 910348011912 motif III; other site 910348011913 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 910348011914 nucleotide binding region [chemical binding]; other site 910348011915 ATP-binding site [chemical binding]; other site 910348011916 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 910348011917 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 910348011918 catalytic residues [active] 910348011919 transcription termination factor Rho; Provisional; Region: rho; PRK09376 910348011920 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 910348011921 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 910348011922 RNA binding site [nucleotide binding]; other site 910348011923 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 910348011924 multimer interface [polypeptide binding]; other site 910348011925 Walker A motif; other site 910348011926 ATP binding site [chemical binding]; other site 910348011927 Walker B motif; other site 910348011928 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 910348011929 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 910348011930 putative catalytic motif [active] 910348011931 substrate binding site [chemical binding]; other site 910348011932 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 910348011933 Chain length determinant protein; Region: Wzz; pfam02706 910348011934 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 910348011935 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 910348011936 homodimer interface [polypeptide binding]; other site 910348011937 active site 910348011938 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 910348011939 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 910348011940 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 910348011941 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 910348011942 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 910348011943 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 910348011944 NAD binding site [chemical binding]; other site 910348011945 substrate binding site [chemical binding]; other site 910348011946 homodimer interface [polypeptide binding]; other site 910348011947 active site 910348011948 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 910348011949 active site 910348011950 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 910348011951 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 910348011952 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 910348011953 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 910348011954 inhibitor-cofactor binding pocket; inhibition site 910348011955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348011956 catalytic residue [active] 910348011957 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 910348011958 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 910348011959 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 910348011960 putative common antigen polymerase; Provisional; Region: PRK02975 910348011961 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 910348011962 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 910348011963 putative transport protein YifK; Provisional; Region: PRK10746 910348011964 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 910348011965 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 910348011966 FeS/SAM binding site; other site 910348011967 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 910348011968 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 910348011969 HemY protein N-terminus; Region: HemY_N; pfam07219 910348011970 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 910348011971 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 910348011972 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 910348011973 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 910348011974 active site 910348011975 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 910348011976 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 910348011977 domain interfaces; other site 910348011978 active site 910348011979 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 910348011980 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 910348011981 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 910348011982 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 910348011983 putative iron binding site [ion binding]; other site 910348011984 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 910348011985 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 910348011986 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 910348011987 hypothetical protein; Provisional; Region: PRK10963 910348011988 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 910348011989 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 910348011990 active site 910348011991 DNA binding site [nucleotide binding] 910348011992 Int/Topo IB signature motif; other site 910348011993 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 910348011994 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 910348011995 motif II; other site 910348011996 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 910348011997 Part of AAA domain; Region: AAA_19; pfam13245 910348011998 Family description; Region: UvrD_C_2; pfam13538 910348011999 Predicted periplasmic protein [Function unknown]; Region: COG3698 910348012000 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 910348012001 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 910348012002 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 910348012003 Cl binding site [ion binding]; other site 910348012004 oligomer interface [polypeptide binding]; other site 910348012005 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 910348012006 hypothetical protein; Provisional; Region: PRK11371 910348012007 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 910348012008 EamA-like transporter family; Region: EamA; cl17759 910348012009 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 910348012010 CoenzymeA binding site [chemical binding]; other site 910348012011 subunit interaction site [polypeptide binding]; other site 910348012012 PHB binding site; other site 910348012013 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 910348012014 dimerization interface [polypeptide binding]; other site 910348012015 substrate binding site [chemical binding]; other site 910348012016 active site 910348012017 calcium binding site [ion binding]; other site 910348012018 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 910348012019 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 910348012020 ATP binding site [chemical binding]; other site 910348012021 putative Mg++ binding site [ion binding]; other site 910348012022 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 910348012023 nucleotide binding region [chemical binding]; other site 910348012024 ATP-binding site [chemical binding]; other site 910348012025 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 910348012026 Helicase and RNase D C-terminal; Region: HRDC; smart00341 910348012027 threonine efflux system; Provisional; Region: PRK10229 910348012028 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 910348012029 lysophospholipase L2; Provisional; Region: PRK10749 910348012030 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 910348012031 putative hydrolase; Provisional; Region: PRK10976 910348012032 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 910348012033 active site 910348012034 motif I; other site 910348012035 motif II; other site 910348012036 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 910348012037 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 910348012038 EamA-like transporter family; Region: EamA; pfam00892 910348012039 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 910348012040 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348012041 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 910348012042 putative dimerization interface [polypeptide binding]; other site 910348012043 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 910348012044 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 910348012045 THF binding site; other site 910348012046 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 910348012047 substrate binding site [chemical binding]; other site 910348012048 THF binding site; other site 910348012049 zinc-binding site [ion binding]; other site 910348012050 uridine phosphorylase; Provisional; Region: PRK11178 910348012051 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 910348012052 DNA recombination protein RmuC; Provisional; Region: PRK10361 910348012053 RmuC family; Region: RmuC; pfam02646 910348012054 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 910348012055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348012056 S-adenosylmethionine binding site [chemical binding]; other site 910348012057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 910348012058 SCP-2 sterol transfer family; Region: SCP2; pfam02036 910348012059 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 910348012060 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 910348012061 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 910348012062 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 910348012063 sec-independent translocase; Provisional; Region: PRK01770 910348012064 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 910348012065 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 910348012066 active site 910348012067 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 910348012068 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 910348012069 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 910348012070 homodimer interface [polypeptide binding]; other site 910348012071 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 910348012072 FMN reductase; Validated; Region: fre; PRK08051 910348012073 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 910348012074 FAD binding pocket [chemical binding]; other site 910348012075 FAD binding motif [chemical binding]; other site 910348012076 phosphate binding motif [ion binding]; other site 910348012077 beta-alpha-beta structure motif; other site 910348012078 NAD binding pocket [chemical binding]; other site 910348012079 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 910348012080 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 910348012081 dimer interface [polypeptide binding]; other site 910348012082 active site 910348012083 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 910348012084 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 910348012085 substrate binding site [chemical binding]; other site 910348012086 oxyanion hole (OAH) forming residues; other site 910348012087 trimer interface [polypeptide binding]; other site 910348012088 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 910348012089 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 910348012090 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 910348012091 proline dipeptidase; Provisional; Region: PRK13607 910348012092 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 910348012093 active site 910348012094 hypothetical protein; Provisional; Region: PRK11568 910348012095 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 910348012096 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 910348012097 potassium transporter; Provisional; Region: PRK10750 910348012098 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 910348012099 Flavodoxin domain; Region: Flavodoxin_5; cl17428 910348012100 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 910348012101 Walker A motif; other site 910348012102 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 910348012103 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 910348012104 GTP binding site; other site 910348012105 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 910348012106 serine/threonine protein kinase; Provisional; Region: PRK11768 910348012107 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 910348012108 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 910348012109 catalytic residues [active] 910348012110 hinge region; other site 910348012111 alpha helical domain; other site 910348012112 Transposase IS200 like; Region: Y1_Tnp; pfam01797 910348012113 hypothetical protein; Provisional; Region: PRK11367 910348012114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 910348012115 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 910348012116 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 910348012117 putative acyl-acceptor binding pocket; other site 910348012118 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 910348012119 DNA polymerase I; Provisional; Region: PRK05755 910348012120 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 910348012121 active site 910348012122 putative 5' ssDNA interaction site; other site 910348012123 metal binding site 3; metal-binding site 910348012124 metal binding site 1 [ion binding]; metal-binding site 910348012125 metal binding site 2 [ion binding]; metal-binding site 910348012126 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 910348012127 putative DNA binding site [nucleotide binding]; other site 910348012128 putative metal binding site [ion binding]; other site 910348012129 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 910348012130 active site 910348012131 catalytic site [active] 910348012132 substrate binding site [chemical binding]; other site 910348012133 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 910348012134 active site 910348012135 DNA binding site [nucleotide binding] 910348012136 catalytic site [active] 910348012137 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 910348012138 G1 box; other site 910348012139 GTP/Mg2+ binding site [chemical binding]; other site 910348012140 Switch I region; other site 910348012141 G2 box; other site 910348012142 G3 box; other site 910348012143 Switch II region; other site 910348012144 G4 box; other site 910348012145 G5 box; other site 910348012146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 910348012147 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 910348012148 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 910348012149 FeS/SAM binding site; other site 910348012150 HemN C-terminal domain; Region: HemN_C; pfam06969 910348012151 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 910348012152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348012153 active site 910348012154 phosphorylation site [posttranslational modification] 910348012155 intermolecular recognition site; other site 910348012156 dimerization interface [polypeptide binding]; other site 910348012157 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348012158 Walker A motif; other site 910348012159 ATP binding site [chemical binding]; other site 910348012160 Walker B motif; other site 910348012161 arginine finger; other site 910348012162 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 910348012163 glutamine synthetase; Provisional; Region: glnA; PRK09469 910348012164 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 910348012165 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 910348012166 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 910348012167 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 910348012168 G2 box; other site 910348012169 Switch I region; other site 910348012170 G3 box; other site 910348012171 Switch II region; other site 910348012172 GTP/Mg2+ binding site [chemical binding]; other site 910348012173 G4 box; other site 910348012174 G5 box; other site 910348012175 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 910348012176 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 910348012177 transcriptional regulator protein; Region: phnR; TIGR03337 910348012178 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 910348012179 DNA-binding site [nucleotide binding]; DNA binding site 910348012180 UTRA domain; Region: UTRA; pfam07702 910348012181 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 910348012182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348012183 putative substrate translocation pore; other site 910348012184 Major Facilitator Superfamily; Region: MFS_1; pfam07690 910348012185 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348012186 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 910348012187 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 910348012188 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 910348012189 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 910348012190 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 910348012191 substrate binding site [chemical binding]; other site 910348012192 ATP binding site [chemical binding]; other site 910348012193 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 910348012194 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 910348012195 Class I aldolases; Region: Aldolase_Class_I; cl17187 910348012196 catalytic residue [active] 910348012197 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 910348012198 putative oxidoreductase; Provisional; Region: PRK10083 910348012199 NAD(P) binding site [chemical binding]; other site 910348012200 benzoate transport; Region: 2A0115; TIGR00895 910348012201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348012202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348012203 shikimate transporter; Provisional; Region: PRK09952 910348012204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348012205 putative substrate translocation pore; other site 910348012206 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 910348012207 active site 910348012208 catalytic residues [active] 910348012209 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 910348012210 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 910348012211 motif II; other site 910348012212 hypothetical protein; Reviewed; Region: PRK01637 910348012213 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 910348012214 putative active site [active] 910348012215 dimerization interface [polypeptide binding]; other site 910348012216 putative tRNAtyr binding site [nucleotide binding]; other site 910348012217 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 910348012218 Coenzyme A binding pocket [chemical binding]; other site 910348012219 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 910348012220 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 910348012221 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 910348012222 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 910348012223 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 910348012224 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 910348012225 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 910348012226 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 910348012227 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 910348012228 molybdopterin cofactor binding site; other site 910348012229 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 910348012230 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 910348012231 molybdopterin cofactor binding site; other site 910348012232 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 910348012233 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 910348012234 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 910348012235 putative frv operon regulatory protein; Provisional; Region: PRK09863 910348012236 HTH domain; Region: HTH_11; pfam08279 910348012237 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 910348012238 active site 910348012239 phosphorylation site [posttranslational modification] 910348012240 putative peptidase; Provisional; Region: PRK09864 910348012241 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 910348012242 oligomer interface [polypeptide binding]; other site 910348012243 active site 910348012244 metal binding site [ion binding]; metal-binding site 910348012245 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 910348012246 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 910348012247 active site 910348012248 P-loop; other site 910348012249 phosphorylation site [posttranslational modification] 910348012250 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 910348012251 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 910348012252 active site 910348012253 phosphorylation site [posttranslational modification] 910348012254 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 910348012255 intersubunit interface [polypeptide binding]; other site 910348012256 active site 910348012257 Zn2+ binding site [ion binding]; other site 910348012258 L-rhamnose isomerase; Provisional; Region: PRK01076 910348012259 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 910348012260 transcriptional activator RhaS; Provisional; Region: PRK13503 910348012261 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 910348012262 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348012263 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348012264 transcriptional activator RhaR; Provisional; Region: PRK13500 910348012265 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 910348012266 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348012267 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348012268 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 910348012269 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 910348012270 superoxide dismutase; Provisional; Region: PRK10925 910348012271 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 910348012272 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 910348012273 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 910348012274 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 910348012275 MOSC domain; Region: MOSC; pfam03473 910348012276 3-alpha domain; Region: 3-alpha; pfam03475 910348012277 two-component sensor protein; Provisional; Region: cpxA; PRK09470 910348012278 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 910348012279 dimerization interface [polypeptide binding]; other site 910348012280 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 910348012281 dimer interface [polypeptide binding]; other site 910348012282 phosphorylation site [posttranslational modification] 910348012283 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348012284 ATP binding site [chemical binding]; other site 910348012285 Mg2+ binding site [ion binding]; other site 910348012286 G-X-G motif; other site 910348012287 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 910348012288 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348012289 active site 910348012290 intermolecular recognition site; other site 910348012291 dimerization interface [polypeptide binding]; other site 910348012292 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 910348012293 DNA binding site [nucleotide binding] 910348012294 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 910348012295 dimer interface [polypeptide binding]; other site 910348012296 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 910348012297 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 910348012298 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 910348012299 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 910348012300 active site 910348012301 ADP/pyrophosphate binding site [chemical binding]; other site 910348012302 dimerization interface [polypeptide binding]; other site 910348012303 allosteric effector site; other site 910348012304 fructose-1,6-bisphosphate binding site; other site 910348012305 sulfate transporter subunit; Provisional; Region: PRK10752 910348012306 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 910348012307 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 910348012308 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 910348012309 triosephosphate isomerase; Provisional; Region: PRK14567 910348012310 substrate binding site [chemical binding]; other site 910348012311 dimer interface [polypeptide binding]; other site 910348012312 catalytic triad [active] 910348012313 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 910348012314 Predicted membrane protein [Function unknown]; Region: COG3152 910348012315 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 910348012316 Ligand Binding Site [chemical binding]; other site 910348012317 ferredoxin-NADP reductase; Provisional; Region: PRK10926 910348012318 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 910348012319 FAD binding pocket [chemical binding]; other site 910348012320 FAD binding motif [chemical binding]; other site 910348012321 phosphate binding motif [ion binding]; other site 910348012322 beta-alpha-beta structure motif; other site 910348012323 NAD binding pocket [chemical binding]; other site 910348012324 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 910348012325 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 910348012326 putative active site [active] 910348012327 glycerol kinase; Provisional; Region: glpK; PRK00047 910348012328 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 910348012329 N- and C-terminal domain interface [polypeptide binding]; other site 910348012330 active site 910348012331 MgATP binding site [chemical binding]; other site 910348012332 catalytic site [active] 910348012333 metal binding site [ion binding]; metal-binding site 910348012334 glycerol binding site [chemical binding]; other site 910348012335 homotetramer interface [polypeptide binding]; other site 910348012336 homodimer interface [polypeptide binding]; other site 910348012337 FBP binding site [chemical binding]; other site 910348012338 protein IIAGlc interface [polypeptide binding]; other site 910348012339 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 910348012340 amphipathic channel; other site 910348012341 Asn-Pro-Ala signature motifs; other site 910348012342 septal ring assembly protein ZapB; Provisional; Region: PRK15422 910348012343 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 910348012344 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 910348012345 UbiA prenyltransferase family; Region: UbiA; pfam01040 910348012346 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 910348012347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348012348 Walker A motif; other site 910348012349 ATP binding site [chemical binding]; other site 910348012350 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 910348012351 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 910348012352 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 910348012353 HslU subunit interaction site [polypeptide binding]; other site 910348012354 essential cell division protein FtsN; Provisional; Region: PRK10927 910348012355 cell division protein FtsN; Provisional; Region: PRK12757 910348012356 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 910348012357 DNA binding site [nucleotide binding] 910348012358 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 910348012359 domain linker motif; other site 910348012360 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 910348012361 dimerization interface [polypeptide binding]; other site 910348012362 ligand binding site [chemical binding]; other site 910348012363 primosome assembly protein PriA; Validated; Region: PRK05580 910348012364 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 910348012365 ATP binding site [chemical binding]; other site 910348012366 putative Mg++ binding site [ion binding]; other site 910348012367 helicase superfamily c-terminal domain; Region: HELICc; smart00490 910348012368 ATP-binding site [chemical binding]; other site 910348012369 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 910348012370 PAAR motif; Region: PAAR_motif; cl15808 910348012371 RHS Repeat; Region: RHS_repeat; pfam05593 910348012372 RHS Repeat; Region: RHS_repeat; pfam05593 910348012373 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 910348012374 RHS Repeat; Region: RHS_repeat; pfam05593 910348012375 RHS protein; Region: RHS; pfam03527 910348012376 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 910348012377 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 910348012378 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 910348012379 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 910348012380 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 910348012381 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 910348012382 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 910348012383 hypothetical protein; Provisional; Region: PRK10030 910348012384 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 910348012385 dimerization interface [polypeptide binding]; other site 910348012386 DNA binding site [nucleotide binding] 910348012387 corepressor binding sites; other site 910348012388 cystathionine gamma-synthase; Provisional; Region: PRK08045 910348012389 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 910348012390 homodimer interface [polypeptide binding]; other site 910348012391 substrate-cofactor binding pocket; other site 910348012392 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348012393 catalytic residue [active] 910348012394 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 910348012395 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 910348012396 putative catalytic residues [active] 910348012397 putative nucleotide binding site [chemical binding]; other site 910348012398 putative aspartate binding site [chemical binding]; other site 910348012399 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 910348012400 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 910348012401 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 910348012402 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 910348012403 FAD binding site [chemical binding]; other site 910348012404 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 910348012405 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 910348012406 heme binding site [chemical binding]; other site 910348012407 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 910348012408 EamA-like transporter family; Region: EamA; pfam00892 910348012409 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 910348012410 EamA-like transporter family; Region: EamA; pfam00892 910348012411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 910348012412 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 910348012413 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 910348012414 dimer interface [polypeptide binding]; other site 910348012415 active site 910348012416 metal binding site [ion binding]; metal-binding site 910348012417 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 910348012418 active site 910348012419 intersubunit interactions; other site 910348012420 catalytic residue [active] 910348012421 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 910348012422 dimerization domain swap beta strand [polypeptide binding]; other site 910348012423 regulatory protein interface [polypeptide binding]; other site 910348012424 active site 910348012425 regulatory phosphorylation site [posttranslational modification]; other site 910348012426 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 910348012427 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 910348012428 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 910348012429 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 910348012430 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 910348012431 active site 910348012432 phosphorylation site [posttranslational modification] 910348012433 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 910348012434 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 910348012435 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 910348012436 active site 910348012437 P-loop; other site 910348012438 phosphorylation site [posttranslational modification] 910348012439 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 910348012440 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 910348012441 dimer interface [polypeptide binding]; other site 910348012442 active site 910348012443 glycine loop; other site 910348012444 pyruvate formate lyase II activase; Provisional; Region: PRK10076 910348012445 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 910348012446 active site 910348012447 P-loop; other site 910348012448 phosphorylation site [posttranslational modification] 910348012449 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 910348012450 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348012451 hypothetical protein; Provisional; Region: PRK10649 910348012452 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 910348012453 Sulfatase; Region: Sulfatase; pfam00884 910348012454 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 910348012455 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 910348012456 acetylornithine deacetylase; Provisional; Region: PRK05111 910348012457 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 910348012458 metal binding site [ion binding]; metal-binding site 910348012459 putative dimer interface [polypeptide binding]; other site 910348012460 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 910348012461 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 910348012462 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 910348012463 nucleotide binding site [chemical binding]; other site 910348012464 N-acetyl-L-glutamate binding site [chemical binding]; other site 910348012465 argininosuccinate lyase; Provisional; Region: PRK04833 910348012466 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 910348012467 active sites [active] 910348012468 tetramer interface [polypeptide binding]; other site 910348012469 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 910348012470 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348012471 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 910348012472 dimerization interface [polypeptide binding]; other site 910348012473 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 910348012474 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 910348012475 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 910348012476 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 910348012477 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 910348012478 hypothetical protein; Provisional; Region: PRK11056 910348012479 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 910348012480 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348012481 S-adenosylmethionine binding site [chemical binding]; other site 910348012482 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 910348012483 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 910348012484 N-terminal plug; other site 910348012485 ligand-binding site [chemical binding]; other site 910348012486 glutamate racemase; Provisional; Region: PRK00865 910348012487 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 910348012488 FAD binding domain; Region: FAD_binding_4; pfam01565 910348012489 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 910348012490 Biotin operon repressor [Transcription]; Region: BirA; COG1654 910348012491 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 910348012492 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 910348012493 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 910348012494 pantothenate kinase; Provisional; Region: PRK05439 910348012495 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 910348012496 ATP-binding site [chemical binding]; other site 910348012497 CoA-binding site [chemical binding]; other site 910348012498 Mg2+-binding site [ion binding]; other site 910348012499 elongation factor Tu; Reviewed; Region: PRK00049 910348012500 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 910348012501 G1 box; other site 910348012502 GEF interaction site [polypeptide binding]; other site 910348012503 GTP/Mg2+ binding site [chemical binding]; other site 910348012504 Switch I region; other site 910348012505 G2 box; other site 910348012506 G3 box; other site 910348012507 Switch II region; other site 910348012508 G4 box; other site 910348012509 G5 box; other site 910348012510 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 910348012511 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 910348012512 Antibiotic Binding Site [chemical binding]; other site 910348012513 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 910348012514 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 910348012515 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 910348012516 putative homodimer interface [polypeptide binding]; other site 910348012517 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 910348012518 heterodimer interface [polypeptide binding]; other site 910348012519 homodimer interface [polypeptide binding]; other site 910348012520 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 910348012521 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 910348012522 23S rRNA interface [nucleotide binding]; other site 910348012523 L7/L12 interface [polypeptide binding]; other site 910348012524 putative thiostrepton binding site; other site 910348012525 L25 interface [polypeptide binding]; other site 910348012526 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 910348012527 mRNA/rRNA interface [nucleotide binding]; other site 910348012528 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 910348012529 23S rRNA interface [nucleotide binding]; other site 910348012530 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 910348012531 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 910348012532 core dimer interface [polypeptide binding]; other site 910348012533 peripheral dimer interface [polypeptide binding]; other site 910348012534 L10 interface [polypeptide binding]; other site 910348012535 L11 interface [polypeptide binding]; other site 910348012536 putative EF-Tu interaction site [polypeptide binding]; other site 910348012537 putative EF-G interaction site [polypeptide binding]; other site 910348012538 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 910348012539 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 910348012540 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 910348012541 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 910348012542 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 910348012543 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 910348012544 RPB3 interaction site [polypeptide binding]; other site 910348012545 RPB1 interaction site [polypeptide binding]; other site 910348012546 RPB11 interaction site [polypeptide binding]; other site 910348012547 RPB10 interaction site [polypeptide binding]; other site 910348012548 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 910348012549 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 910348012550 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 910348012551 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 910348012552 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 910348012553 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 910348012554 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 910348012555 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 910348012556 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 910348012557 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 910348012558 DNA binding site [nucleotide binding] 910348012559 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 910348012560 stationary phase growth adaptation protein; Provisional; Region: PRK09717 910348012561 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 910348012562 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 910348012563 FeS/SAM binding site; other site 910348012564 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 910348012565 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 910348012566 ThiS interaction site; other site 910348012567 putative active site [active] 910348012568 tetramer interface [polypeptide binding]; other site 910348012569 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 910348012570 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 910348012571 ATP binding site [chemical binding]; other site 910348012572 substrate interface [chemical binding]; other site 910348012573 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 910348012574 thiamine phosphate binding site [chemical binding]; other site 910348012575 active site 910348012576 pyrophosphate binding site [ion binding]; other site 910348012577 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 910348012578 ThiC-associated domain; Region: ThiC-associated; pfam13667 910348012579 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 910348012580 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 910348012581 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 910348012582 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 910348012583 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 910348012584 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 910348012585 putative NADH binding site [chemical binding]; other site 910348012586 putative active site [active] 910348012587 nudix motif; other site 910348012588 putative metal binding site [ion binding]; other site 910348012589 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 910348012590 substrate binding site [chemical binding]; other site 910348012591 active site 910348012592 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 910348012593 Active_site [active] 910348012594 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 910348012595 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 910348012596 IHF dimer interface [polypeptide binding]; other site 910348012597 IHF - DNA interface [nucleotide binding]; other site 910348012598 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 910348012599 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 910348012600 dimer interface [polypeptide binding]; other site 910348012601 sensor protein ZraS; Provisional; Region: PRK10364 910348012602 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 910348012603 dimer interface [polypeptide binding]; other site 910348012604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348012605 ATP binding site [chemical binding]; other site 910348012606 Mg2+ binding site [ion binding]; other site 910348012607 G-X-G motif; other site 910348012608 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 910348012609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348012610 active site 910348012611 phosphorylation site [posttranslational modification] 910348012612 intermolecular recognition site; other site 910348012613 dimerization interface [polypeptide binding]; other site 910348012614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348012615 Walker A motif; other site 910348012616 ATP binding site [chemical binding]; other site 910348012617 Walker B motif; other site 910348012618 arginine finger; other site 910348012619 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 910348012620 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 910348012621 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 910348012622 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 910348012623 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 910348012624 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 910348012625 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 910348012626 purine monophosphate binding site [chemical binding]; other site 910348012627 dimer interface [polypeptide binding]; other site 910348012628 putative catalytic residues [active] 910348012629 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 910348012630 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 910348012631 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 910348012632 Coenzyme A binding pocket [chemical binding]; other site 910348012633 homoserine O-succinyltransferase; Provisional; Region: PRK05368 910348012634 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 910348012635 proposed active site lysine [active] 910348012636 conserved cys residue [active] 910348012637 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 910348012638 malate synthase A; Region: malate_syn_A; TIGR01344 910348012639 active site 910348012640 isocitrate lyase; Provisional; Region: PRK15063 910348012641 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 910348012642 tetramer interface [polypeptide binding]; other site 910348012643 active site 910348012644 Mg2+/Mn2+ binding site [ion binding]; other site 910348012645 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 910348012646 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 910348012647 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 910348012648 transcriptional repressor IclR; Provisional; Region: PRK11569 910348012649 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 910348012650 Bacterial transcriptional regulator; Region: IclR; pfam01614 910348012651 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 910348012652 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 910348012653 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 910348012654 substrate binding pocket [chemical binding]; other site 910348012655 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 910348012656 B12 binding site [chemical binding]; other site 910348012657 cobalt ligand [ion binding]; other site 910348012658 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 910348012659 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 910348012660 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 910348012661 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 910348012662 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 910348012663 active site pocket [active] 910348012664 oxyanion hole [active] 910348012665 catalytic triad [active] 910348012666 active site nucleophile [active] 910348012667 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 910348012668 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 910348012669 RNA binding surface [nucleotide binding]; other site 910348012670 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 910348012671 probable active site [active] 910348012672 aspartate kinase III; Validated; Region: PRK09084 910348012673 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 910348012674 nucleotide binding site [chemical binding]; other site 910348012675 substrate binding site [chemical binding]; other site 910348012676 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 910348012677 lysine allosteric regulatory site; other site 910348012678 dimer interface [polypeptide binding]; other site 910348012679 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 910348012680 dimer interface [polypeptide binding]; other site 910348012681 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 910348012682 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 910348012683 active site 910348012684 dimer interface [polypeptide binding]; other site 910348012685 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 910348012686 dimer interface [polypeptide binding]; other site 910348012687 active site 910348012688 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 910348012689 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 910348012690 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 910348012691 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 910348012692 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 910348012693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348012694 putative substrate translocation pore; other site 910348012695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348012696 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 910348012697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348012698 dimer interface [polypeptide binding]; other site 910348012699 conserved gate region; other site 910348012700 putative PBP binding loops; other site 910348012701 ABC-ATPase subunit interface; other site 910348012702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348012703 dimer interface [polypeptide binding]; other site 910348012704 conserved gate region; other site 910348012705 putative PBP binding loops; other site 910348012706 ABC-ATPase subunit interface; other site 910348012707 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 910348012708 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 910348012709 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 910348012710 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 910348012711 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 910348012712 Walker A/P-loop; other site 910348012713 ATP binding site [chemical binding]; other site 910348012714 Q-loop/lid; other site 910348012715 ABC transporter signature motif; other site 910348012716 Walker B; other site 910348012717 D-loop; other site 910348012718 H-loop/switch region; other site 910348012719 TOBE domain; Region: TOBE_2; pfam08402 910348012720 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 910348012721 trimer interface; other site 910348012722 sugar binding site [chemical binding]; other site 910348012723 maltose regulon periplasmic protein; Provisional; Region: PRK10564 910348012724 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 910348012725 SopA-like central domain; Region: SopA; pfam13981 910348012726 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 910348012727 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 910348012728 UbiA prenyltransferase family; Region: UbiA; pfam01040 910348012729 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 910348012730 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 910348012731 putative acyl-acceptor binding pocket; other site 910348012732 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 910348012733 LexA repressor; Validated; Region: PRK00215 910348012734 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 910348012735 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 910348012736 Catalytic site [active] 910348012737 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 910348012738 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 910348012739 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 910348012740 metal binding site 2 [ion binding]; metal-binding site 910348012741 putative DNA binding helix; other site 910348012742 metal binding site 1 [ion binding]; metal-binding site 910348012743 dimer interface [polypeptide binding]; other site 910348012744 structural Zn2+ binding site [ion binding]; other site 910348012745 Protein of unknown function (DUF2713); Region: DUF2713; pfam10897 910348012746 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 910348012747 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 910348012748 FMN binding site [chemical binding]; other site 910348012749 active site 910348012750 catalytic residues [active] 910348012751 substrate binding site [chemical binding]; other site 910348012752 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 910348012753 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 910348012754 NADP binding site [chemical binding]; other site 910348012755 dimer interface [polypeptide binding]; other site 910348012756 replicative DNA helicase; Provisional; Region: PRK08006 910348012757 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 910348012758 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 910348012759 Walker A motif; other site 910348012760 ATP binding site [chemical binding]; other site 910348012761 Walker B motif; other site 910348012762 DNA binding loops [nucleotide binding] 910348012763 alanine racemase; Reviewed; Region: alr; PRK00053 910348012764 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 910348012765 active site 910348012766 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 910348012767 substrate binding site [chemical binding]; other site 910348012768 catalytic residues [active] 910348012769 dimer interface [polypeptide binding]; other site 910348012770 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 910348012771 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 910348012772 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348012773 homodimer interface [polypeptide binding]; other site 910348012774 catalytic residue [active] 910348012775 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 910348012776 active site 910348012777 motif I; other site 910348012778 motif II; other site 910348012779 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 910348012780 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 910348012781 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 910348012782 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 910348012783 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 910348012784 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 910348012785 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 910348012786 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 910348012787 dimer interface [polypeptide binding]; other site 910348012788 ssDNA binding site [nucleotide binding]; other site 910348012789 tetramer (dimer of dimers) interface [polypeptide binding]; other site 910348012790 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 910348012791 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 910348012792 active site 910348012793 catalytic residues [active] 910348012794 Int/Topo IB signature motif; other site 910348012795 DNA binding site [nucleotide binding] 910348012796 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 910348012797 DNA binding site [nucleotide binding] 910348012798 active site 910348012799 Int/Topo IB signature motif; other site 910348012800 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 910348012801 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 910348012802 DEAD-like helicases superfamily; Region: DEXDc; smart00487 910348012803 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 910348012804 ATP binding site [chemical binding]; other site 910348012805 putative Mg++ binding site [ion binding]; other site 910348012806 T5orf172 domain; Region: T5orf172; pfam10544 910348012807 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 910348012808 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 910348012809 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 910348012810 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 910348012811 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348012812 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 910348012813 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 910348012814 DNA binding residues [nucleotide binding] 910348012815 dimer interface [polypeptide binding]; other site 910348012816 [2Fe-2S] cluster binding site [ion binding]; other site 910348012817 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 910348012818 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 910348012819 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 910348012820 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 910348012821 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 910348012822 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 910348012823 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 910348012824 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 910348012825 Na binding site [ion binding]; other site 910348012826 acetyl-CoA synthetase; Provisional; Region: PRK00174 910348012827 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 910348012828 active site 910348012829 CoA binding site [chemical binding]; other site 910348012830 acyl-activating enzyme (AAE) consensus motif; other site 910348012831 AMP binding site [chemical binding]; other site 910348012832 acetate binding site [chemical binding]; other site 910348012833 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 910348012834 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 910348012835 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 910348012836 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 910348012837 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 910348012838 heme lyase subunit NrfE; Provisional; Region: PRK10369 910348012839 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 910348012840 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 910348012841 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 910348012842 binding surface 910348012843 TPR motif; other site 910348012844 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 910348012845 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 910348012846 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 910348012847 Sel1-like repeats; Region: SEL1; smart00671 910348012848 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 910348012849 molybdopterin cofactor binding site; other site 910348012850 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 910348012851 molybdopterin cofactor binding site; other site 910348012852 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 910348012853 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 910348012854 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 910348012855 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 910348012856 multidrug resistance protein MdtN; Provisional; Region: PRK10476 910348012857 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 910348012858 HlyD family secretion protein; Region: HlyD_3; pfam13437 910348012859 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 910348012860 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 910348012861 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 910348012862 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 910348012863 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 910348012864 Coenzyme A binding pocket [chemical binding]; other site 910348012865 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 910348012866 AAA domain; Region: AAA_18; pfam13238 910348012867 active site 910348012868 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 910348012869 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 910348012870 active site 910348012871 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 910348012872 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 910348012873 Walker A/P-loop; other site 910348012874 ATP binding site [chemical binding]; other site 910348012875 Q-loop/lid; other site 910348012876 ABC transporter signature motif; other site 910348012877 Walker B; other site 910348012878 D-loop; other site 910348012879 H-loop/switch region; other site 910348012880 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 910348012881 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 910348012882 Walker A/P-loop; other site 910348012883 ATP binding site [chemical binding]; other site 910348012884 Q-loop/lid; other site 910348012885 ABC transporter signature motif; other site 910348012886 Walker B; other site 910348012887 D-loop; other site 910348012888 H-loop/switch region; other site 910348012889 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 910348012890 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 910348012891 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 910348012892 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 910348012893 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 910348012894 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 910348012895 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 910348012896 DNA-binding site [nucleotide binding]; DNA binding site 910348012897 UTRA domain; Region: UTRA; pfam07702 910348012898 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 910348012899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 910348012900 dimer interface [polypeptide binding]; other site 910348012901 conserved gate region; other site 910348012902 putative PBP binding loops; other site 910348012903 ABC-ATPase subunit interface; other site 910348012904 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 910348012905 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 910348012906 substrate binding pocket [chemical binding]; other site 910348012907 membrane-bound complex binding site; other site 910348012908 hinge residues; other site 910348012909 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 910348012910 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 910348012911 Walker A/P-loop; other site 910348012912 ATP binding site [chemical binding]; other site 910348012913 Q-loop/lid; other site 910348012914 ABC transporter signature motif; other site 910348012915 Walker B; other site 910348012916 D-loop; other site 910348012917 H-loop/switch region; other site 910348012918 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 910348012919 dimer interface [polypeptide binding]; other site 910348012920 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 910348012921 hypothetical protein; Provisional; Region: PRK09866 910348012922 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 910348012923 G1 box; other site 910348012924 GTP/Mg2+ binding site [chemical binding]; other site 910348012925 G2 box; other site 910348012926 Switch I region; other site 910348012927 G3 box; other site 910348012928 Switch II region; other site 910348012929 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 910348012930 G2 box; other site 910348012931 Switch I region; other site 910348012932 G3 box; other site 910348012933 Switch II region; other site 910348012934 G4 box; other site 910348012935 G5 box; other site 910348012936 YjcZ-like protein; Region: YjcZ; pfam13990 910348012937 proline/glycine betaine transporter; Provisional; Region: PRK10642 910348012938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348012939 putative substrate translocation pore; other site 910348012940 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 910348012941 sensor protein BasS/PmrB; Provisional; Region: PRK10755 910348012942 HAMP domain; Region: HAMP; pfam00672 910348012943 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 910348012944 dimer interface [polypeptide binding]; other site 910348012945 phosphorylation site [posttranslational modification] 910348012946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348012947 ATP binding site [chemical binding]; other site 910348012948 Mg2+ binding site [ion binding]; other site 910348012949 G-X-G motif; other site 910348012950 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 910348012951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348012952 active site 910348012953 phosphorylation site [posttranslational modification] 910348012954 intermolecular recognition site; other site 910348012955 dimerization interface [polypeptide binding]; other site 910348012956 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 910348012957 DNA binding site [nucleotide binding] 910348012958 putative metal dependent hydrolase; Provisional; Region: PRK11598 910348012959 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 910348012960 Sulfatase; Region: Sulfatase; pfam00884 910348012961 arginine:agmatin antiporter; Provisional; Region: PRK10644 910348012962 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 910348012963 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348012964 arginine decarboxylase; Provisional; Region: PRK15029 910348012965 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 910348012966 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 910348012967 homodimer interface [polypeptide binding]; other site 910348012968 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348012969 catalytic residue [active] 910348012970 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 910348012971 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 910348012972 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348012973 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348012974 alpha-galactosidase; Provisional; Region: PRK15076 910348012975 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 910348012976 NAD binding site [chemical binding]; other site 910348012977 sugar binding site [chemical binding]; other site 910348012978 divalent metal binding site [ion binding]; other site 910348012979 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 910348012980 dimer interface [polypeptide binding]; other site 910348012981 melibiose:sodium symporter; Provisional; Region: PRK10429 910348012982 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 910348012983 hypothetical protein; Provisional; Region: PRK09867 910348012984 fumarate hydratase; Provisional; Region: PRK15389 910348012985 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 910348012986 Fumarase C-terminus; Region: Fumerase_C; pfam05683 910348012987 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 910348012988 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 910348012989 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 910348012990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348012991 active site 910348012992 phosphorylation site [posttranslational modification] 910348012993 intermolecular recognition site; other site 910348012994 dimerization interface [polypeptide binding]; other site 910348012995 Transcriptional regulator; Region: CitT; pfam12431 910348012996 sensory histidine kinase DcuS; Provisional; Region: PRK11086 910348012997 PAS domain; Region: PAS; smart00091 910348012998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348012999 ATP binding site [chemical binding]; other site 910348013000 Mg2+ binding site [ion binding]; other site 910348013001 G-X-G motif; other site 910348013002 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 910348013003 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 910348013004 dimer interface [polypeptide binding]; other site 910348013005 putative anticodon binding site; other site 910348013006 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 910348013007 motif 1; other site 910348013008 active site 910348013009 motif 2; other site 910348013010 motif 3; other site 910348013011 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 910348013012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348013013 putative substrate translocation pore; other site 910348013014 POT family; Region: PTR2; pfam00854 910348013015 lysine decarboxylase CadA; Provisional; Region: PRK15400 910348013016 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 910348013017 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 910348013018 homodimer interface [polypeptide binding]; other site 910348013019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348013020 catalytic residue [active] 910348013021 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 910348013022 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 910348013023 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 910348013024 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 910348013025 DNA binding site [nucleotide binding] 910348013026 putative transcriptional regulator; Provisional; Region: PRK11640 910348013027 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 910348013028 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 910348013029 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 910348013030 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 910348013031 DsbD alpha interface [polypeptide binding]; other site 910348013032 catalytic residues [active] 910348013033 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 910348013034 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 910348013035 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 910348013036 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 910348013037 Aspartase; Region: Aspartase; cd01357 910348013038 active sites [active] 910348013039 tetramer interface [polypeptide binding]; other site 910348013040 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 910348013041 putative transporter; Provisional; Region: PRK11021 910348013042 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 910348013043 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 910348013044 ring oligomerisation interface [polypeptide binding]; other site 910348013045 ATP/Mg binding site [chemical binding]; other site 910348013046 stacking interactions; other site 910348013047 hinge regions; other site 910348013048 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 910348013049 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 910348013050 FeS/SAM binding site; other site 910348013051 elongation factor P; Validated; Region: PRK00529 910348013052 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 910348013053 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 910348013054 RNA binding site [nucleotide binding]; other site 910348013055 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 910348013056 RNA binding site [nucleotide binding]; other site 910348013057 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 910348013058 multidrug efflux system protein; Provisional; Region: PRK11431 910348013059 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 910348013060 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 910348013061 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 910348013062 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 910348013063 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 910348013064 Iron-sulfur protein interface; other site 910348013065 proximal quinone binding site [chemical binding]; other site 910348013066 C-subunit interface; other site 910348013067 distal quinone binding site; other site 910348013068 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 910348013069 D-subunit interface [polypeptide binding]; other site 910348013070 Iron-sulfur protein interface; other site 910348013071 proximal quinone binding site [chemical binding]; other site 910348013072 distal quinone binding site [chemical binding]; other site 910348013073 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 910348013074 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 910348013075 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 910348013076 L-aspartate oxidase; Provisional; Region: PRK06175 910348013077 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 910348013078 poxB regulator PoxA; Provisional; Region: PRK09350 910348013079 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 910348013080 motif 1; other site 910348013081 dimer interface [polypeptide binding]; other site 910348013082 active site 910348013083 motif 2; other site 910348013084 motif 3; other site 910348013085 inner membrane transporter YjeM; Provisional; Region: PRK15238 910348013086 putative mechanosensitive channel protein; Provisional; Region: PRK10929 910348013087 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 910348013088 DNA-binding site [nucleotide binding]; DNA binding site 910348013089 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 910348013090 Mechanosensitive ion channel; Region: MS_channel; pfam00924 910348013091 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 910348013092 Predicted GTPases [General function prediction only]; Region: COG1162 910348013093 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 910348013094 RNA binding site [nucleotide binding]; other site 910348013095 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 910348013096 GTPase/Zn-binding domain interface [polypeptide binding]; other site 910348013097 GTP/Mg2+ binding site [chemical binding]; other site 910348013098 G4 box; other site 910348013099 G5 box; other site 910348013100 G1 box; other site 910348013101 Switch I region; other site 910348013102 G2 box; other site 910348013103 G3 box; other site 910348013104 Switch II region; other site 910348013105 epoxyqueuosine reductase; Region: TIGR00276 910348013106 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 910348013107 putative carbohydrate kinase; Provisional; Region: PRK10565 910348013108 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 910348013109 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 910348013110 putative substrate binding site [chemical binding]; other site 910348013111 putative ATP binding site [chemical binding]; other site 910348013112 ADP-binding protein; Provisional; Region: PRK10646 910348013113 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 910348013114 AMIN domain; Region: AMIN; pfam11741 910348013115 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 910348013116 active site 910348013117 metal binding site [ion binding]; metal-binding site 910348013118 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 910348013119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348013120 ATP binding site [chemical binding]; other site 910348013121 Mg2+ binding site [ion binding]; other site 910348013122 G-X-G motif; other site 910348013123 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 910348013124 ATP binding site [chemical binding]; other site 910348013125 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 910348013126 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 910348013127 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 910348013128 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; cl17639 910348013129 bacterial Hfq-like; Region: Hfq; cd01716 910348013130 hexamer interface [polypeptide binding]; other site 910348013131 Sm1 motif; other site 910348013132 RNA binding site [nucleotide binding]; other site 910348013133 Sm2 motif; other site 910348013134 GTPase HflX; Provisional; Region: PRK11058 910348013135 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 910348013136 HflX GTPase family; Region: HflX; cd01878 910348013137 G1 box; other site 910348013138 GTP/Mg2+ binding site [chemical binding]; other site 910348013139 Switch I region; other site 910348013140 G2 box; other site 910348013141 G3 box; other site 910348013142 Switch II region; other site 910348013143 G4 box; other site 910348013144 G5 box; other site 910348013145 FtsH protease regulator HflK; Provisional; Region: PRK10930 910348013146 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 910348013147 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 910348013148 FtsH protease regulator HflC; Provisional; Region: PRK11029 910348013149 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 910348013150 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 910348013151 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 910348013152 GDP-binding site [chemical binding]; other site 910348013153 ACT binding site; other site 910348013154 IMP binding site; other site 910348013155 Predicted transcriptional regulator [Transcription]; Region: COG1959 910348013156 transcriptional repressor NsrR; Provisional; Region: PRK11014 910348013157 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 910348013158 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 910348013159 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 910348013160 Transcriptional regulator [Transcription]; Region: IclR; COG1414 910348013161 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 910348013162 Bacterial transcriptional regulator; Region: IclR; pfam01614 910348013163 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 910348013164 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 910348013165 inhibitor site; inhibition site 910348013166 active site 910348013167 dimer interface [polypeptide binding]; other site 910348013168 catalytic residue [active] 910348013169 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 910348013170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348013171 putative substrate translocation pore; other site 910348013172 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 910348013173 galactarate dehydratase; Region: galactar-dH20; TIGR03248 910348013174 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 910348013175 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 910348013176 PspA/IM30 family; Region: PspA_IM30; pfam04012 910348013177 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 910348013178 Predicted membrane protein [Function unknown]; Region: COG3766 910348013179 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 910348013180 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 910348013181 Predicted integral membrane protein [Function unknown]; Region: COG5463 910348013182 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 910348013183 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 910348013184 active site 910348013185 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 910348013186 esterase; Provisional; Region: PRK10566 910348013187 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 910348013188 transcriptional repressor UlaR; Provisional; Region: PRK13509 910348013189 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 910348013190 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 910348013191 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 910348013192 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 910348013193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 910348013194 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 910348013195 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 910348013196 active site 910348013197 P-loop; other site 910348013198 phosphorylation site [posttranslational modification] 910348013199 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 910348013200 active site 910348013201 phosphorylation site [posttranslational modification] 910348013202 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 910348013203 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 910348013204 AP (apurinic/apyrimidinic) site pocket; other site 910348013205 DNA interaction; other site 910348013206 Metal-binding active site; metal-binding site 910348013207 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 910348013208 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 910348013209 intersubunit interface [polypeptide binding]; other site 910348013210 active site 910348013211 Zn2+ binding site [ion binding]; other site 910348013212 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 910348013213 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 910348013214 dimer interface [polypeptide binding]; other site 910348013215 ssDNA binding site [nucleotide binding]; other site 910348013216 tetramer (dimer of dimers) interface [polypeptide binding]; other site 910348013217 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 910348013218 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 910348013219 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 910348013220 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 910348013221 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348013222 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 910348013223 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 910348013224 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 910348013225 L-aspartate oxidase; Provisional; Region: PRK06175 910348013226 L-aspartate oxidase; Provisional; Region: PRK06175 910348013227 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 910348013228 Coenzyme A transferase; Region: CoA_trans; smart00882 910348013229 Coenzyme A transferase; Region: CoA_trans; cl17247 910348013230 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 910348013231 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 910348013232 substrate binding site [chemical binding]; other site 910348013233 oxyanion hole (OAH) forming residues; other site 910348013234 trimer interface [polypeptide binding]; other site 910348013235 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 910348013236 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 910348013237 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337 910348013238 putative NAD(P) binding site [chemical binding]; other site 910348013239 active site 910348013240 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 910348013241 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 910348013242 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 910348013243 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 910348013244 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 910348013245 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 910348013246 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 910348013247 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 910348013248 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 910348013249 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 910348013250 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 910348013251 Hemerythrin-like domain; Region: Hr-like; cd12108 910348013252 Fe binding site [ion binding]; other site 910348013253 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 910348013254 EamA-like transporter family; Region: EamA; pfam00892 910348013255 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 910348013256 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 910348013257 NADP binding site [chemical binding]; other site 910348013258 Predicted transcriptional regulators [Transcription]; Region: COG1733 910348013259 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 910348013260 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 910348013261 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 910348013262 active site 910348013263 metal binding site [ion binding]; metal-binding site 910348013264 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 910348013265 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 910348013266 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 910348013267 active site 910348013268 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398 910348013269 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398 910348013270 Transporter associated domain; Region: CorC_HlyC; smart01091 910348013271 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 910348013272 Domain of unknown function DUF21; Region: DUF21; pfam01595 910348013273 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 910348013274 methionine sulfoxide reductase A; Provisional; Region: PRK00058 910348013275 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 910348013276 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 910348013277 Surface antigen; Region: Bac_surface_Ag; pfam01103 910348013278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 910348013279 Family of unknown function (DUF490); Region: DUF490; pfam04357 910348013280 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 910348013281 toxin ChpB; Provisional; Region: PRK09812 910348013282 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 910348013283 dimer interface [polypeptide binding]; other site 910348013284 substrate binding site [chemical binding]; other site 910348013285 metal binding sites [ion binding]; metal-binding site 910348013286 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 910348013287 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 910348013288 putative ligand binding site [chemical binding]; other site 910348013289 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 910348013290 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 910348013291 Walker A/P-loop; other site 910348013292 ATP binding site [chemical binding]; other site 910348013293 Q-loop/lid; other site 910348013294 ABC transporter signature motif; other site 910348013295 Walker B; other site 910348013296 D-loop; other site 910348013297 H-loop/switch region; other site 910348013298 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 910348013299 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 910348013300 Walker B; other site 910348013301 D-loop; other site 910348013302 H-loop/switch region; other site 910348013303 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 910348013304 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 910348013305 TM-ABC transporter signature motif; other site 910348013306 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 910348013307 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 910348013308 TM-ABC transporter signature motif; other site 910348013309 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 910348013310 AMP binding site [chemical binding]; other site 910348013311 metal binding site [ion binding]; metal-binding site 910348013312 active site 910348013313 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 910348013314 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 910348013315 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 910348013316 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 910348013317 hypothetical protein; Provisional; Region: PRK05255 910348013318 peptidase PmbA; Provisional; Region: PRK11040 910348013319 Cytochrome b562; Region: Cytochrom_B562; cl01546 910348013320 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 910348013321 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 910348013322 FeS/SAM binding site; other site 910348013323 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 910348013324 Class III ribonucleotide reductase; Region: RNR_III; cd01675 910348013325 active site 910348013326 effector binding site; other site 910348013327 Zn binding site [ion binding]; other site 910348013328 glycine loop; other site 910348013329 ATP cone domain; Region: ATP-cone; pfam03477 910348013330 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 910348013331 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 910348013332 Ca binding site [ion binding]; other site 910348013333 active site 910348013334 catalytic site [active] 910348013335 PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826 910348013336 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 910348013337 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 910348013338 trehalose repressor; Provisional; Region: treR; PRK09492 910348013339 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 910348013340 DNA binding site [nucleotide binding] 910348013341 domain linker motif; other site 910348013342 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 910348013343 dimerization interface [polypeptide binding]; other site 910348013344 ligand binding site [chemical binding]; other site 910348013345 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 910348013346 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 910348013347 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 910348013348 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 910348013349 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 910348013350 motif II; other site 910348013351 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 910348013352 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 910348013353 homotrimer interaction site [polypeptide binding]; other site 910348013354 putative active site [active] 910348013355 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 910348013356 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 910348013357 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 910348013358 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 910348013359 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 910348013360 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 910348013361 PyrBI operon leader peptide; Region: PyrBI_leader; pfam08052 910348013362 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 910348013363 homotrimer interaction site [polypeptide binding]; other site 910348013364 putative active site [active] 910348013365 oxidoreductase; Provisional; Region: PRK12742 910348013366 classical (c) SDRs; Region: SDR_c; cd05233 910348013367 NAD(P) binding site [chemical binding]; other site 910348013368 active site 910348013369 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 910348013370 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 910348013371 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 910348013372 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 910348013373 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 910348013374 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 910348013375 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 910348013376 RNase E inhibitor protein; Provisional; Region: PRK11191 910348013377 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 910348013378 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 910348013379 Coenzyme A binding pocket [chemical binding]; other site 910348013380 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 910348013381 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348013382 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 910348013383 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 910348013384 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 910348013385 HIGH motif; other site 910348013386 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 910348013387 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 910348013388 active site 910348013389 KMSKS motif; other site 910348013390 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 910348013391 tRNA binding surface [nucleotide binding]; other site 910348013392 anticodon binding site; other site 910348013393 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 910348013394 DNA polymerase III subunit chi; Validated; Region: PRK05728 910348013395 multifunctional aminopeptidase A; Provisional; Region: PRK00913 910348013396 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 910348013397 interface (dimer of trimers) [polypeptide binding]; other site 910348013398 Substrate-binding/catalytic site; other site 910348013399 Zn-binding sites [ion binding]; other site 910348013400 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 910348013401 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 910348013402 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 910348013403 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 910348013404 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 910348013405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 910348013406 Walker A motif; other site 910348013407 ATP binding site [chemical binding]; other site 910348013408 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 910348013409 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 910348013410 DNA binding site [nucleotide binding] 910348013411 domain linker motif; other site 910348013412 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 910348013413 putative dimerization interface [polypeptide binding]; other site 910348013414 putative ligand binding site [chemical binding]; other site 910348013415 fructuronate transporter; Provisional; Region: PRK10034; cl15264 910348013416 gluconate transporter; Region: gntP; TIGR00791 910348013417 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 910348013418 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 910348013419 NADP binding site [chemical binding]; other site 910348013420 homodimer interface [polypeptide binding]; other site 910348013421 active site 910348013422 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 910348013423 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 910348013424 putative NAD(P) binding site [chemical binding]; other site 910348013425 catalytic Zn binding site [ion binding]; other site 910348013426 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 910348013427 ATP-binding site [chemical binding]; other site 910348013428 Gluconate-6-phosphate binding site [chemical binding]; other site 910348013429 Shikimate kinase; Region: SKI; pfam01202 910348013430 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 910348013431 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 910348013432 putative NAD(P) binding site [chemical binding]; other site 910348013433 putative substrate binding site [chemical binding]; other site 910348013434 catalytic Zn binding site [ion binding]; other site 910348013435 structural Zn binding site [ion binding]; other site 910348013436 dimer interface [polypeptide binding]; other site 910348013437 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 910348013438 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 910348013439 active site 910348013440 Int/Topo IB signature motif; other site 910348013441 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 910348013442 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 910348013443 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 910348013444 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348013445 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 910348013446 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 910348013447 Transposase; Region: HTH_Tnp_1; cl17663 910348013448 putative transposase OrfB; Reviewed; Region: PHA02517 910348013449 Integrase core domain; Region: rve_3; pfam13683 910348013450 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 910348013451 putative PBP binding regions; other site 910348013452 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 910348013453 ABC-ATPase subunit interface; other site 910348013454 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 910348013455 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 910348013456 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 910348013457 dimer interface [polypeptide binding]; other site 910348013458 ABC-ATPase subunit interface; other site 910348013459 putative PBP binding regions; other site 910348013460 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 910348013461 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 910348013462 siderophore binding site; other site 910348013463 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 910348013464 Secretin and TonB N terminus short domain; Region: STN; smart00965 910348013465 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 910348013466 N-terminal plug; other site 910348013467 ligand-binding site [chemical binding]; other site 910348013468 fec operon regulator FecR; Reviewed; Region: PRK09774 910348013469 FecR protein; Region: FecR; pfam04773 910348013470 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 910348013471 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 910348013472 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 910348013473 DNA binding residues [nucleotide binding] 910348013474 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 910348013475 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 910348013476 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 910348013477 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 910348013478 PapC C-terminal domain; Region: PapC_C; pfam13953 910348013479 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 910348013480 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 910348013481 fructuronate transporter; Provisional; Region: PRK10034 910348013482 gluconate transporter; Region: gntP; TIGR00791 910348013483 mannonate dehydratase; Region: uxuA; TIGR00695 910348013484 mannonate dehydratase; Provisional; Region: PRK03906 910348013485 D-mannonate oxidoreductase; Provisional; Region: PRK15037 910348013486 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 910348013487 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 910348013488 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 910348013489 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 910348013490 DNA-binding site [nucleotide binding]; DNA binding site 910348013491 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 910348013492 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 910348013493 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 910348013494 cell density-dependent motility repressor; Provisional; Region: PRK10082 910348013495 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 910348013496 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 910348013497 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 910348013498 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 910348013499 dimer interface [polypeptide binding]; other site 910348013500 active site 910348013501 hypothetical protein; Provisional; Region: PRK10519 910348013502 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 910348013503 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 910348013504 Major Facilitator Superfamily; Region: MFS_1; pfam07690 910348013505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348013506 putative substrate translocation pore; other site 910348013507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 910348013508 SdiA-regulated; Region: SdiA-regulated; cd09971 910348013509 putative active site [active] 910348013510 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 910348013511 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 910348013512 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 910348013513 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 910348013514 Predicted membrane protein [Function unknown]; Region: COG2733 910348013515 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 910348013516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348013517 putative substrate translocation pore; other site 910348013518 putative transposase; Provisional; Region: PRK09857 910348013519 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 910348013520 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 910348013521 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 910348013522 DNA-binding site [nucleotide binding]; DNA binding site 910348013523 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 910348013524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 910348013525 homodimer interface [polypeptide binding]; other site 910348013526 catalytic residue [active] 910348013527 Uncharacterized conserved protein [Function unknown]; Region: COG1479 910348013528 Protein of unknown function DUF262; Region: DUF262; pfam03235 910348013529 Protein of unknown function DUF262; Region: DUF262; pfam03235 910348013530 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 910348013531 Uncharacterized conserved protein [Function unknown]; Region: COG3586 910348013532 endoribonuclease SymE; Provisional; Region: PRK13605 910348013533 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 910348013534 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 910348013535 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 910348013536 ATP binding site [chemical binding]; other site 910348013537 putative Mg++ binding site [ion binding]; other site 910348013538 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 910348013539 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 910348013540 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 910348013541 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 910348013542 HsdM N-terminal domain; Region: HsdM_N; pfam12161 910348013543 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 910348013544 Methyltransferase domain; Region: Methyltransf_26; pfam13659 910348013545 Restriction endonuclease; Region: Mrr_cat; pfam04471 910348013546 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 910348013547 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 910348013548 P-loop, Walker A motif; other site 910348013549 Base recognition motif; other site 910348013550 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 910348013551 carbon starvation protein A; Provisional; Region: PRK15015 910348013552 Carbon starvation protein CstA; Region: CstA; pfam02554 910348013553 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 910348013554 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 910348013555 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 910348013556 dimer interface [polypeptide binding]; other site 910348013557 ligand binding site [chemical binding]; other site 910348013558 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 910348013559 dimerization interface [polypeptide binding]; other site 910348013560 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 910348013561 dimer interface [polypeptide binding]; other site 910348013562 putative CheW interface [polypeptide binding]; other site 910348013563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 910348013564 D-galactonate transporter; Region: 2A0114; TIGR00893 910348013565 putative substrate translocation pore; other site 910348013566 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 910348013567 DNA-binding site [nucleotide binding]; DNA binding site 910348013568 Transcriptional regulators [Transcription]; Region: GntR; COG1802 910348013569 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 910348013570 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 910348013571 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 910348013572 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 910348013573 putative NAD(P) binding site [chemical binding]; other site 910348013574 catalytic Zn binding site [ion binding]; other site 910348013575 structural Zn binding site [ion binding]; other site 910348013576 Sulfatase; Region: Sulfatase; cl17466 910348013577 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 910348013578 hypothetical protein; Provisional; Region: PRK11667 910348013579 DNA replication protein DnaC; Validated; Region: PRK07952 910348013580 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 910348013581 Walker A motif; other site 910348013582 ATP binding site [chemical binding]; other site 910348013583 Walker B motif; other site 910348013584 primosomal protein DnaI; Provisional; Region: PRK02854 910348013585 hypothetical protein; Provisional; Region: PRK09917 910348013586 Uncharacterized conserved protein [Function unknown]; Region: COG2966 910348013587 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 910348013588 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 910348013589 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 910348013590 DNA binding residues [nucleotide binding] 910348013591 dimerization interface [polypeptide binding]; other site 910348013592 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 910348013593 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 910348013594 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 910348013595 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 910348013596 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 910348013597 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 910348013598 S-adenosylmethionine binding site [chemical binding]; other site 910348013599 DNA polymerase III subunit psi; Validated; Region: PRK06856 910348013600 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 910348013601 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 910348013602 Coenzyme A binding pocket [chemical binding]; other site 910348013603 dUMP phosphatase; Provisional; Region: PRK09449 910348013604 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 910348013605 motif II; other site 910348013606 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 910348013607 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 910348013608 G1 box; other site 910348013609 putative GEF interaction site [polypeptide binding]; other site 910348013610 GTP/Mg2+ binding site [chemical binding]; other site 910348013611 Switch I region; other site 910348013612 G2 box; other site 910348013613 G3 box; other site 910348013614 Switch II region; other site 910348013615 G4 box; other site 910348013616 G5 box; other site 910348013617 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 910348013618 periplasmic protein; Provisional; Region: PRK10568 910348013619 BON domain; Region: BON; pfam04972 910348013620 BON domain; Region: BON; pfam04972 910348013621 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 910348013622 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 910348013623 nucleophile elbow; other site 910348013624 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 910348013625 active site 910348013626 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 910348013627 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 910348013628 FeS/SAM binding site; other site 910348013629 hypothetical protein; Provisional; Region: PRK10977 910348013630 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 910348013631 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 910348013632 intersubunit interface [polypeptide binding]; other site 910348013633 active site 910348013634 catalytic residue [active] 910348013635 thymidine phosphorylase; Region: T_phosphoryl; TIGR02643 910348013636 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 910348013637 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 910348013638 phosphopentomutase; Provisional; Region: PRK05362 910348013639 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 910348013640 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 910348013641 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 910348013642 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 910348013643 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 910348013644 putative Zn2+ binding site [ion binding]; other site 910348013645 putative DNA binding site [nucleotide binding]; other site 910348013646 HipA-like N-terminal domain; Region: HipA_N; pfam07805 910348013647 HipA-like C-terminal domain; Region: HipA_C; pfam07804 910348013648 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 910348013649 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 910348013650 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 910348013651 hypothetical protein; Provisional; Region: PRK11246 910348013652 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 910348013653 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 910348013654 motif II; other site 910348013655 DNA repair protein RadA; Provisional; Region: PRK11823 910348013656 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 910348013657 ATP binding site [chemical binding]; other site 910348013658 Walker B motif; other site 910348013659 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 910348013660 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 910348013661 non-specific DNA binding site [nucleotide binding]; other site 910348013662 salt bridge; other site 910348013663 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 910348013664 sequence-specific DNA binding site [nucleotide binding]; other site 910348013665 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 910348013666 active site 910348013667 (T/H)XGH motif; other site 910348013668 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 910348013669 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 910348013670 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 910348013671 Walker A/P-loop; other site 910348013672 ATP binding site [chemical binding]; other site 910348013673 Q-loop/lid; other site 910348013674 ABC transporter signature motif; other site 910348013675 Walker B; other site 910348013676 D-loop; other site 910348013677 H-loop/switch region; other site 910348013678 ABC transporter; Region: ABC_tran_2; pfam12848 910348013679 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 910348013680 lytic murein transglycosylase; Provisional; Region: PRK11619 910348013681 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 910348013682 N-acetyl-D-glucosamine binding site [chemical binding]; other site 910348013683 catalytic residue [active] 910348013684 Trp operon repressor; Provisional; Region: PRK01381 910348013685 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 910348013686 catalytic core [active] 910348013687 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 910348013688 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 910348013689 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 910348013690 hypothetical protein; Provisional; Region: PRK10756 910348013691 CreA protein; Region: CreA; pfam05981 910348013692 DNA-binding response regulator CreB; Provisional; Region: PRK11083 910348013693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348013694 active site 910348013695 phosphorylation site [posttranslational modification] 910348013696 intermolecular recognition site; other site 910348013697 dimerization interface [polypeptide binding]; other site 910348013698 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 910348013699 DNA binding site [nucleotide binding] 910348013700 sensory histidine kinase CreC; Provisional; Region: PRK11100 910348013701 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 910348013702 dimerization interface [polypeptide binding]; other site 910348013703 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 910348013704 dimer interface [polypeptide binding]; other site 910348013705 phosphorylation site [posttranslational modification] 910348013706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 910348013707 ATP binding site [chemical binding]; other site 910348013708 Mg2+ binding site [ion binding]; other site 910348013709 G-X-G motif; other site 910348013710 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 910348013711 two-component response regulator; Provisional; Region: PRK11173 910348013712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 910348013713 active site 910348013714 phosphorylation site [posttranslational modification] 910348013715 intermolecular recognition site; other site 910348013716 dimerization interface [polypeptide binding]; other site 910348013717 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 910348013718 DNA binding site [nucleotide binding] 910348013719 putative RNA methyltransferase; Provisional; Region: PRK10433 910348013720 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050