-- dump date 20140619_090557 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1382700000001 homoserine kinase; Region: thrB; TIGR00191 1382700000002 Protein of unknown function; Region: YhfT; pfam10797 1382700000003 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1382700000004 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1382700000005 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1382700000006 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1382700000007 catalytic residue [active] 1382700000008 hypothetical protein; Provisional; Region: PRK10659 1382700000009 chaperone protein DnaJ; Provisional; Region: PRK10767 1382700000010 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1382700000011 HSP70 interaction site [polypeptide binding]; other site 1382700000012 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1382700000013 substrate binding site [polypeptide binding]; other site 1382700000014 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1382700000015 Zn binding sites [ion binding]; other site 1382700000016 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1382700000017 dimer interface [polypeptide binding]; other site 1382700000018 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 1382700000019 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1382700000020 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1382700000021 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1382700000022 active site 1382700000023 Riboflavin kinase; Region: Flavokinase; smart00904 1382700000024 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1382700000025 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1382700000026 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1382700000027 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 1382700000028 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1382700000029 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1382700000030 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1382700000031 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 1382700000032 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1382700000033 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 1382700000034 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1382700000035 active site 1382700000036 putative oxidoreductase FixC; Provisional; Region: PRK10157 1382700000037 ferredoxin-like protein FixX; Provisional; Region: PRK15449 1382700000038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1382700000039 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1382700000040 putative substrate translocation pore; other site 1382700000041 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1382700000042 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1382700000043 folate binding site [chemical binding]; other site 1382700000044 NADP+ binding site [chemical binding]; other site 1382700000045 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1382700000046 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1382700000047 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1382700000048 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1382700000049 SurA N-terminal domain; Region: SurA_N; pfam09312 1382700000050 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1382700000051 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1382700000052 L-arabinose isomerase; Provisional; Region: PRK02929 1382700000053 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1382700000054 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1382700000055 trimer interface [polypeptide binding]; other site 1382700000056 putative substrate binding site [chemical binding]; other site 1382700000057 putative metal binding site [ion binding]; other site 1382700000058 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1382700000059 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1382700000060 substrate binding site [chemical binding]; other site 1382700000061 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1382700000062 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1382700000063 substrate binding site [chemical binding]; other site 1382700000064 ligand binding site [chemical binding]; other site 1382700000065 2-isopropylmalate synthase; Validated; Region: PRK00915 1382700000066 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1382700000067 active site 1382700000068 catalytic residues [active] 1382700000069 metal binding site [ion binding]; metal-binding site 1382700000070 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1382700000071 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1382700000072 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1382700000073 putative valine binding site [chemical binding]; other site 1382700000074 dimer interface [polypeptide binding]; other site 1382700000075 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1382700000076 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1382700000077 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1382700000078 DNA binding site [nucleotide binding] 1382700000079 domain linker motif; other site 1382700000080 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1382700000081 dimerization interface [polypeptide binding]; other site 1382700000082 ligand binding site [chemical binding]; other site 1382700000083 mraZ protein; Region: TIGR00242 1382700000084 MraZ protein; Region: MraZ; pfam02381 1382700000085 MraZ protein; Region: MraZ; pfam02381 1382700000086 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 1382700000087 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1382700000088 cell division protein FtsL; Provisional; Region: PRK10772 1382700000089 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1382700000090 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1382700000091 Mg++ binding site [ion binding]; other site 1382700000092 putative catalytic motif [active] 1382700000093 putative substrate binding site [chemical binding]; other site 1382700000094 cell division protein FtsW; Provisional; Region: PRK10774 1382700000095 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1382700000096 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1382700000097 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1382700000098 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1382700000099 cell division protein FtsQ; Provisional; Region: PRK10775 1382700000100 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1382700000101 Cell division protein FtsQ; Region: FtsQ; pfam03799 1382700000102 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 1382700000103 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1382700000104 Cell division protein FtsA; Region: FtsA; pfam14450 1382700000105 cell division protein FtsZ; Validated; Region: PRK09330 1382700000106 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1382700000107 nucleotide binding site [chemical binding]; other site 1382700000108 SulA interaction site; other site 1382700000109 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1382700000110 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1382700000111 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1382700000112 active site 1382700000113 8-oxo-dGMP binding site [chemical binding]; other site 1382700000114 nudix motif; other site 1382700000115 metal binding site [ion binding]; metal-binding site 1382700000116 DNA gyrase inhibitor; Reviewed; Region: PRK00418 1382700000117 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 1382700000118 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 1382700000119 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1382700000120 active site 1382700000121 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 1382700000122 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1382700000123 dimerization interface [polypeptide binding]; other site 1382700000124 active site 1382700000125 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1382700000126 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1382700000127 DNA-binding site [nucleotide binding]; DNA binding site 1382700000128 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1382700000129 hypothetical protein; Provisional; Region: PRK05248 1382700000130 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1382700000131 active site clefts [active] 1382700000132 zinc binding site [ion binding]; other site 1382700000133 dimer interface [polypeptide binding]; other site 1382700000134 inner membrane transport permease; Provisional; Region: PRK15066 1382700000135 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1382700000136 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1382700000137 tetramerization interface [polypeptide binding]; other site 1382700000138 active site 1382700000139 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1382700000140 oligomerization interface [polypeptide binding]; other site 1382700000141 active site 1382700000142 metal binding site [ion binding]; metal-binding site 1382700000143 putative chaperone protein EcpD; Provisional; Region: PRK09926 1382700000144 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1382700000145 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1382700000146 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 1382700000147 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 1382700000148 Transglycosylase; Region: Transgly; pfam00912 1382700000149 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1382700000150 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1382700000151 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1382700000152 Cl- selectivity filter; other site 1382700000153 Cl- binding residues [ion binding]; other site 1382700000154 pore gating glutamate residue; other site 1382700000155 dimer interface [polypeptide binding]; other site 1382700000156 H+/Cl- coupling transport residue; other site 1382700000157 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1382700000158 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1382700000159 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1382700000160 serine endoprotease; Provisional; Region: PRK10942 1382700000161 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1382700000162 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1382700000163 protein binding site [polypeptide binding]; other site 1382700000164 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1382700000165 hypothetical protein; Provisional; Region: PRK13677 1382700000166 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1382700000167 active site 1382700000168 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1382700000169 rRNA interaction site [nucleotide binding]; other site 1382700000170 S8 interaction site; other site 1382700000171 putative laminin-1 binding site; other site 1382700000172 elongation factor Ts; Provisional; Region: tsf; PRK09377 1382700000173 UBA/TS-N domain; Region: UBA; pfam00627 1382700000174 Elongation factor TS; Region: EF_TS; pfam00889 1382700000175 Elongation factor TS; Region: EF_TS; pfam00889 1382700000176 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1382700000177 putative nucleotide binding site [chemical binding]; other site 1382700000178 uridine monophosphate binding site [chemical binding]; other site 1382700000179 homohexameric interface [polypeptide binding]; other site 1382700000180 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1382700000181 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1382700000182 hinge region; other site 1382700000183 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1382700000184 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1382700000185 catalytic residue [active] 1382700000186 putative FPP diphosphate binding site; other site 1382700000187 putative FPP binding hydrophobic cleft; other site 1382700000188 dimer interface [polypeptide binding]; other site 1382700000189 putative IPP diphosphate binding site; other site 1382700000190 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 1382700000191 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1382700000192 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1382700000193 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1382700000194 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1382700000195 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1382700000196 Surface antigen; Region: Bac_surface_Ag; pfam01103 1382700000197 periplasmic chaperone; Provisional; Region: PRK10780 1382700000198 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1382700000199 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1382700000200 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1382700000201 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1382700000202 active site 1382700000203 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1382700000204 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1382700000205 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 1382700000206 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 1382700000207 lipoprotein, YaeC family; Region: TIGR00363 1382700000208 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1382700000209 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1382700000210 Walker A/P-loop; other site 1382700000211 ATP binding site [chemical binding]; other site 1382700000212 Q-loop/lid; other site 1382700000213 ABC transporter signature motif; other site 1382700000214 Walker B; other site 1382700000215 D-loop; other site 1382700000216 H-loop/switch region; other site 1382700000217 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1382700000218 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1382700000219 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1382700000220 active site 1382700000221 catalytic tetrad [active] 1382700000222 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1382700000223 RNA/DNA hybrid binding site [nucleotide binding]; other site 1382700000224 active site 1382700000225 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1382700000226 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1382700000227 active site 1382700000228 catalytic site [active] 1382700000229 substrate binding site [chemical binding]; other site 1382700000230 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1382700000231 dimer interface [polypeptide binding]; other site 1382700000232 active site 1382700000233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1382700000234 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1382700000235 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 1382700000236 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1382700000237 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1382700000238 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1382700000239 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1382700000240 active site 1382700000241 catalytic tetrad [active] 1382700000242 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1382700000243 Cysteine-rich domain; Region: CCG; pfam02754 1382700000244 Cysteine-rich domain; Region: CCG; pfam02754 1382700000245 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1382700000246 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1382700000247 putative substrate binding site [chemical binding]; other site 1382700000248 nucleotide binding site [chemical binding]; other site 1382700000249 nucleotide binding site [chemical binding]; other site 1382700000250 homodimer interface [polypeptide binding]; other site 1382700000251 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1382700000252 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1382700000253 ligand binding site [chemical binding]; other site 1382700000254 hypothetical protein; Provisional; Region: PRK09929 1382700000255 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1382700000256 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1382700000257 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 1382700000258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1382700000259 putative substrate translocation pore; other site 1382700000260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 1382700000261 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1382700000262 putative metal binding site [ion binding]; other site 1382700000263 putative homodimer interface [polypeptide binding]; other site 1382700000264 putative homotetramer interface [polypeptide binding]; other site 1382700000265 putative homodimer-homodimer interface [polypeptide binding]; other site 1382700000266 putative allosteric switch controlling residues; other site 1382700000267 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1382700000268 dimer interface [polypeptide binding]; other site 1382700000269 active site 1382700000270 Schiff base residues; other site 1382700000271 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 1382700000272 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 1382700000273 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1382700000274 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1382700000275 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1382700000276 anti-RssB factor; Provisional; Region: PRK10244 1382700000277 hypothetical protein; Provisional; Region: PRK11505 1382700000278 psiF repeat; Region: PsiF_repeat; pfam07769 1382700000279 psiF repeat; Region: PsiF_repeat; pfam07769 1382700000280 hypothetical protein; Validated; Region: PRK00124 1382700000281 hypothetical protein; Provisional; Region: PRK10481 1382700000282 hypothetical protein; Provisional; Region: PRK10579 1382700000283 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 1382700000284 transcriptional regulator PhoB; Provisional; Region: PRK10161 1382700000285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1382700000286 active site 1382700000287 phosphorylation site [posttranslational modification] 1382700000288 intermolecular recognition site; other site 1382700000289 dimerization interface [polypeptide binding]; other site 1382700000290 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1382700000291 DNA binding site [nucleotide binding] 1382700000292 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 1382700000293 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1382700000294 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1382700000295 putative active site [active] 1382700000296 heme pocket [chemical binding]; other site 1382700000297 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1382700000298 dimer interface [polypeptide binding]; other site 1382700000299 phosphorylation site [posttranslational modification] 1382700000300 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1382700000301 ATP binding site [chemical binding]; other site 1382700000302 Mg2+ binding site [ion binding]; other site 1382700000303 G-X-G motif; other site 1382700000304 putative proline-specific permease; Provisional; Region: proY; PRK10580 1382700000305 Spore germination protein; Region: Spore_permease; cl17796 1382700000306 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1382700000307 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 1382700000308 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1382700000309 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1382700000310 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1382700000311 Protein export membrane protein; Region: SecD_SecF; pfam02355 1382700000312 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1382700000313 ATP cone domain; Region: ATP-cone; pfam03477 1382700000314 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1382700000315 putative RNA binding site [nucleotide binding]; other site 1382700000316 thiamine monophosphate kinase; Provisional; Region: PRK05731 1382700000317 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1382700000318 ATP binding site [chemical binding]; other site 1382700000319 dimerization interface [polypeptide binding]; other site 1382700000320 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1382700000321 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 1382700000322 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1382700000323 conserved cys residue [active] 1382700000324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1382700000325 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1382700000326 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1382700000327 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1382700000328 D-pathway; other site 1382700000329 Putative ubiquinol binding site [chemical binding]; other site 1382700000330 Low-spin heme (heme b) binding site [chemical binding]; other site 1382700000331 Putative water exit pathway; other site 1382700000332 Binuclear center (heme o3/CuB) [ion binding]; other site 1382700000333 K-pathway; other site 1382700000334 Putative proton exit pathway; other site 1382700000335 hypothetical protein; Provisional; Region: PRK11627 1382700000336 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 1382700000337 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1382700000338 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1382700000339 oligomer interface [polypeptide binding]; other site 1382700000340 active site residues [active] 1382700000341 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1382700000342 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1382700000343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1382700000344 Walker A motif; other site 1382700000345 ATP binding site [chemical binding]; other site 1382700000346 Walker B motif; other site 1382700000347 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1382700000348 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 1382700000349 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1382700000350 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1382700000351 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1382700000352 Walker A motif; other site 1382700000353 ATP binding site [chemical binding]; other site 1382700000354 Walker B motif; other site 1382700000355 arginine finger; other site 1382700000356 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1382700000357 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1382700000358 IHF dimer interface [polypeptide binding]; other site 1382700000359 IHF - DNA interface [nucleotide binding]; other site 1382700000360 periplasmic folding chaperone; Provisional; Region: PRK10788 1382700000361 SurA N-terminal domain; Region: SurA_N_3; cl07813 1382700000362 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1382700000363 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 1382700000364 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1382700000365 active site 1382700000366 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1382700000367 Ligand Binding Site [chemical binding]; other site 1382700000368 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 1382700000369 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1382700000370 active site 1382700000371 motif I; other site 1382700000372 motif II; other site 1382700000373 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1382700000374 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1382700000375 putative DNA binding site [nucleotide binding]; other site 1382700000376 putative Zn2+ binding site [ion binding]; other site 1382700000377 AsnC family; Region: AsnC_trans_reg; pfam01037 1382700000378 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 1382700000379 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1382700000380 Uncharacterized conserved protein [Function unknown]; Region: COG5507 1382700000381 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 1382700000382 gene expression modulator; Provisional; Region: PRK10945 1382700000383 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 1382700000384 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1382700000385 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1382700000386 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1382700000387 hypothetical protein; Provisional; Region: PRK11038 1382700000388 hypothetical protein; Provisional; Region: PRK10527 1382700000389 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1382700000390 active site 1382700000391 hypothetical protein; Validated; Region: PRK00153 1382700000392 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 1382700000393 RecR protein; Region: RecR; pfam02132 1382700000394 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1382700000395 putative active site [active] 1382700000396 putative metal-binding site [ion binding]; other site 1382700000397 tetramer interface [polypeptide binding]; other site 1382700000398 inosine/guanosine kinase; Provisional; Region: PRK15074 1382700000399 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1382700000400 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1382700000401 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1382700000402 non-specific DNA binding site [nucleotide binding]; other site 1382700000403 salt bridge; other site 1382700000404 sequence-specific DNA binding site [nucleotide binding]; other site 1382700000405 amino acid transporter; Region: 2A0306; TIGR00909 1382700000406 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 1382700000407 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1382700000408 DNA binding residues [nucleotide binding] 1382700000409 dimer interface [polypeptide binding]; other site 1382700000410 copper binding site [ion binding]; other site 1382700000411 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1382700000412 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1382700000413 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 1382700000414 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1382700000415 Na binding site [ion binding]; other site 1382700000416 substrate binding site [chemical binding]; other site 1382700000417 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 1382700000418 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1382700000419 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1382700000420 active site 1382700000421 HIGH motif; other site 1382700000422 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1382700000423 KMSKS motif; other site 1382700000424 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1382700000425 tRNA binding surface [nucleotide binding]; other site 1382700000426 anticodon binding site; other site 1382700000427 ribosome-associated protein; Provisional; Region: PRK11507 1382700000428 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1382700000429 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1382700000430 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1382700000431 homodimer interface [polypeptide binding]; other site 1382700000432 NADP binding site [chemical binding]; other site 1382700000433 substrate binding site [chemical binding]; other site 1382700000434 gpW; Region: gpW; pfam02831 1382700000435 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 1382700000436 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 1382700000437 Minor tail protein T; Region: Phage_tail_T; pfam06223 1382700000438 sensor kinase CusS; Provisional; Region: PRK09835 1382700000439 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1382700000440 dimerization interface [polypeptide binding]; other site 1382700000441 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1382700000442 dimer interface [polypeptide binding]; other site 1382700000443 phosphorylation site [posttranslational modification] 1382700000444 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1382700000445 ATP binding site [chemical binding]; other site 1382700000446 Mg2+ binding site [ion binding]; other site 1382700000447 G-X-G motif; other site 1382700000448 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 1382700000449 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1382700000450 active site 1382700000451 phosphorylation site [posttranslational modification] 1382700000452 intermolecular recognition site; other site 1382700000453 dimerization interface [polypeptide binding]; other site 1382700000454 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1382700000455 DNA binding site [nucleotide binding] 1382700000456 phenylalanine transporter; Provisional; Region: PRK10249 1382700000457 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1382700000458 dimer interface [polypeptide binding]; other site 1382700000459 FMN binding site [chemical binding]; other site 1382700000460 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 1382700000461 outer membrane receptor FepA; Provisional; Region: PRK13524 1382700000462 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1382700000463 N-terminal plug; other site 1382700000464 ligand-binding site [chemical binding]; other site 1382700000465 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1382700000466 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1382700000467 ABC-ATPase subunit interface; other site 1382700000468 dimer interface [polypeptide binding]; other site 1382700000469 putative PBP binding regions; other site 1382700000470 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 1382700000471 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1382700000472 siderophore binding site; other site 1382700000473 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1382700000474 hydrophobic substrate binding pocket; other site 1382700000475 Isochorismatase family; Region: Isochorismatase; pfam00857 1382700000476 active site 1382700000477 conserved cis-peptide bond; other site 1382700000478 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1382700000479 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1382700000480 CoenzymeA binding site [chemical binding]; other site 1382700000481 subunit interaction site [polypeptide binding]; other site 1382700000482 PHB binding site; other site 1382700000483 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 1382700000484 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1382700000485 dimer interface [polypeptide binding]; other site 1382700000486 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1382700000487 catalytic triad [active] 1382700000488 peroxidatic and resolving cysteines [active] 1382700000489 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1382700000490 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1382700000491 catalytic residue [active] 1382700000492 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1382700000493 catalytic residues [active] 1382700000494 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1382700000495 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1382700000496 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1382700000497 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1382700000498 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1382700000499 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1382700000500 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 1382700000501 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 1382700000502 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1382700000503 active site 1382700000504 phosphorylation site [posttranslational modification] 1382700000505 intermolecular recognition site; other site 1382700000506 dimerization interface [polypeptide binding]; other site 1382700000507 Transcriptional regulator; Region: CitT; pfam12431 1382700000508 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 1382700000509 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1382700000510 chromosome condensation membrane protein; Provisional; Region: PRK14196 1382700000511 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 1382700000512 lipoyl synthase; Provisional; Region: PRK05481 1382700000513 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1382700000514 FeS/SAM binding site; other site 1382700000515 lipoate-protein ligase B; Provisional; Region: PRK14342 1382700000516 hypothetical protein; Provisional; Region: PRK04998 1382700000517 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 1382700000518 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1382700000519 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1382700000520 penicillin-binding protein 2; Provisional; Region: PRK10795 1382700000521 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1382700000522 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1382700000523 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 1382700000524 ribosome-associated protein; Provisional; Region: PRK11538 1382700000525 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1382700000526 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1382700000527 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 1382700000528 hypothetical protein; Provisional; Region: PRK11032 1382700000529 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1382700000530 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1382700000531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1382700000532 dimer interface [polypeptide binding]; other site 1382700000533 conserved gate region; other site 1382700000534 putative PBP binding loops; other site 1382700000535 ABC-ATPase subunit interface; other site 1382700000536 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 1382700000537 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1382700000538 Transporter associated domain; Region: CorC_HlyC; smart01091 1382700000539 metal-binding heat shock protein; Provisional; Region: PRK00016 1382700000540 asparagine synthetase B; Provisional; Region: asnB; PRK09431 1382700000541 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1382700000542 active site 1382700000543 dimer interface [polypeptide binding]; other site 1382700000544 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1382700000545 Ligand Binding Site [chemical binding]; other site 1382700000546 Molecular Tunnel; other site 1382700000547 UMP phosphatase; Provisional; Region: PRK10444 1382700000548 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1382700000549 active site 1382700000550 motif I; other site 1382700000551 motif II; other site 1382700000552 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1382700000553 MarR family; Region: MarR; pfam01047 1382700000554 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1382700000555 ROK family; Region: ROK; pfam00480 1382700000556 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1382700000557 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1382700000558 active site 1382700000559 dimer interface [polypeptide binding]; other site 1382700000560 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1382700000561 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1382700000562 active site 1382700000563 trimer interface [polypeptide binding]; other site 1382700000564 allosteric site; other site 1382700000565 active site lid [active] 1382700000566 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1382700000567 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 1382700000568 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1382700000569 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1382700000570 active site turn [active] 1382700000571 phosphorylation site [posttranslational modification] 1382700000572 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1382700000573 HPr interaction site; other site 1382700000574 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1382700000575 active site 1382700000576 phosphorylation site [posttranslational modification] 1382700000577 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1382700000578 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1382700000579 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1382700000580 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1382700000581 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1382700000582 active site 1382700000583 HIGH motif; other site 1382700000584 nucleotide binding site [chemical binding]; other site 1382700000585 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1382700000586 KMSKS motif; other site 1382700000587 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1382700000588 YbfN-like lipoprotein; Region: YbfN; pfam13982 1382700000589 ferric uptake regulator; Provisional; Region: fur; PRK09462 1382700000590 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1382700000591 metal binding site 2 [ion binding]; metal-binding site 1382700000592 putative DNA binding helix; other site 1382700000593 metal binding site 1 [ion binding]; metal-binding site 1382700000594 dimer interface [polypeptide binding]; other site 1382700000595 structural Zn2+ binding site [ion binding]; other site 1382700000596 flavodoxin FldA; Validated; Region: PRK09267 1382700000597 LexA regulated protein; Provisional; Region: PRK11675 1382700000598 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1382700000599 metal-binding protein; Provisional; Region: PRK10799 1382700000600 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 1382700000601 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1382700000602 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1382700000603 dimer interface [polypeptide binding]; other site 1382700000604 active site 1382700000605 citrylCoA binding site [chemical binding]; other site 1382700000606 NADH binding [chemical binding]; other site 1382700000607 cationic pore residues; other site 1382700000608 oxalacetate/citrate binding site [chemical binding]; other site 1382700000609 coenzyme A binding site [chemical binding]; other site 1382700000610 catalytic triad [active] 1382700000611 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1382700000612 SdhC subunit interface [polypeptide binding]; other site 1382700000613 proximal heme binding site [chemical binding]; other site 1382700000614 cardiolipin binding site; other site 1382700000615 Iron-sulfur protein interface; other site 1382700000616 proximal quinone binding site [chemical binding]; other site 1382700000617 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 1382700000618 L-aspartate oxidase; Provisional; Region: PRK06175 1382700000619 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1382700000620 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1382700000621 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1382700000622 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1382700000623 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1382700000624 TPP-binding site [chemical binding]; other site 1382700000625 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1382700000626 dimer interface [polypeptide binding]; other site 1382700000627 PYR/PP interface [polypeptide binding]; other site 1382700000628 TPP binding site [chemical binding]; other site 1382700000629 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1382700000630 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1382700000631 CoA-ligase; Region: Ligase_CoA; pfam00549 1382700000632 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1382700000633 CoA binding domain; Region: CoA_binding; smart00881 1382700000634 CoA-ligase; Region: Ligase_CoA; pfam00549 1382700000635 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1382700000636 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1382700000637 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 1382700000638 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1382700000639 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 1382700000640 hypothetical protein; Provisional; Region: PRK10588 1382700000641 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1382700000642 active site 1382700000643 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1382700000644 colicin uptake protein TolR; Provisional; Region: PRK11024 1382700000645 translocation protein TolB; Provisional; Region: tolB; PRK03629 1382700000646 TolB amino-terminal domain; Region: TolB_N; pfam04052 1382700000647 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1382700000648 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1382700000649 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1382700000650 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 1382700000651 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1382700000652 catalytic core [active] 1382700000653 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1382700000654 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 1382700000655 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 1382700000656 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1382700000657 motif II; other site 1382700000658 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1382700000659 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1382700000660 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1382700000661 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1382700000662 putative dimerization interface [polypeptide binding]; other site 1382700000663 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1382700000664 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1382700000665 transmembrane helices; other site 1382700000666 acyl-CoA thioesterase; Provisional; Region: PRK10531 1382700000667 putative pectinesterase; Region: PLN02432; cl01911 1382700000668 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1382700000669 substrate binding site [chemical binding]; other site 1382700000670 excinuclease ABC subunit B; Provisional; Region: PRK05298 1382700000671 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1382700000672 ATP binding site [chemical binding]; other site 1382700000673 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1382700000674 nucleotide binding region [chemical binding]; other site 1382700000675 ATP-binding site [chemical binding]; other site 1382700000676 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1382700000677 UvrB/uvrC motif; Region: UVR; pfam02151 1382700000678 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1382700000679 MPT binding site; other site 1382700000680 trimer interface [polypeptide binding]; other site 1382700000681 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1382700000682 trimer interface [polypeptide binding]; other site 1382700000683 dimer interface [polypeptide binding]; other site 1382700000684 putative active site [active] 1382700000685 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1382700000686 MoaE homodimer interface [polypeptide binding]; other site 1382700000687 MoaD interaction [polypeptide binding]; other site 1382700000688 active site residues [active] 1382700000689 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1382700000690 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1382700000691 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1382700000692 putative catalytic site [active] 1382700000693 putative metal binding site [ion binding]; other site 1382700000694 putative phosphate binding site [ion binding]; other site 1382700000695 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1382700000696 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1382700000697 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1382700000698 DEAD_2; Region: DEAD_2; pfam06733 1382700000699 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1382700000700 glycosyl transferase family protein; Provisional; Region: PRK08136 1382700000701 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1382700000702 hypothetical protein; Provisional; Region: PRK10259 1382700000703 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 1382700000704 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1382700000705 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 1382700000706 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1382700000707 Walker A/P-loop; other site 1382700000708 ATP binding site [chemical binding]; other site 1382700000709 Q-loop/lid; other site 1382700000710 ABC transporter signature motif; other site 1382700000711 Walker B; other site 1382700000712 D-loop; other site 1382700000713 H-loop/switch region; other site 1382700000714 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1382700000715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1382700000716 dimer interface [polypeptide binding]; other site 1382700000717 conserved gate region; other site 1382700000718 putative PBP binding loops; other site 1382700000719 ABC-ATPase subunit interface; other site 1382700000720 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 1382700000721 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1382700000722 substrate binding pocket [chemical binding]; other site 1382700000723 membrane-bound complex binding site; other site 1382700000724 hinge residues; other site 1382700000725 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1382700000726 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1382700000727 dimerization interface [polypeptide binding]; other site 1382700000728 DPS ferroxidase diiron center [ion binding]; other site 1382700000729 ion pore; other site 1382700000730 threonine and homoserine efflux system; Provisional; Region: PRK10532 1382700000731 EamA-like transporter family; Region: EamA; pfam00892 1382700000732 outer membrane protein X; Provisional; Region: ompX; PRK09408 1382700000733 manganese transport regulator MntR; Provisional; Region: PRK11050 1382700000734 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1382700000735 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1382700000736 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1382700000737 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1382700000738 transmembrane helices; other site 1382700000739 L,D-transpeptidase; Provisional; Region: PRK10260 1382700000740 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1382700000741 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1382700000742 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1382700000743 Walker A/P-loop; other site 1382700000744 ATP binding site [chemical binding]; other site 1382700000745 Q-loop/lid; other site 1382700000746 ABC transporter signature motif; other site 1382700000747 Walker B; other site 1382700000748 D-loop; other site 1382700000749 H-loop/switch region; other site 1382700000750 ABC transporter; Region: ABC_tran_2; pfam12848 1382700000751 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1382700000752 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 1382700000753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1382700000754 dimer interface [polypeptide binding]; other site 1382700000755 conserved gate region; other site 1382700000756 putative PBP binding loops; other site 1382700000757 ABC-ATPase subunit interface; other site 1382700000758 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1382700000759 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1382700000760 metal binding site [ion binding]; metal-binding site 1382700000761 active site 1382700000762 I-site; other site 1382700000763 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 1382700000764 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1382700000765 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1382700000766 putative C-terminal domain interface [polypeptide binding]; other site 1382700000767 putative GSH binding site (G-site) [chemical binding]; other site 1382700000768 putative dimer interface [polypeptide binding]; other site 1382700000769 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1382700000770 N-terminal domain interface [polypeptide binding]; other site 1382700000771 dimer interface [polypeptide binding]; other site 1382700000772 substrate binding pocket (H-site) [chemical binding]; other site 1382700000773 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1382700000774 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1382700000775 active site 1382700000776 putative transporter; Provisional; Region: PRK04972 1382700000777 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1382700000778 TrkA-C domain; Region: TrkA_C; pfam02080 1382700000779 TrkA-C domain; Region: TrkA_C; pfam02080 1382700000780 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1382700000781 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 1382700000782 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1382700000783 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1382700000784 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1382700000785 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1382700000786 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1382700000787 Walker A/P-loop; other site 1382700000788 ATP binding site [chemical binding]; other site 1382700000789 Q-loop/lid; other site 1382700000790 ABC transporter signature motif; other site 1382700000791 Walker B; other site 1382700000792 D-loop; other site 1382700000793 H-loop/switch region; other site 1382700000794 TOBE domain; Region: TOBE_2; pfam08402 1382700000795 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1382700000796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1382700000797 dimer interface [polypeptide binding]; other site 1382700000798 conserved gate region; other site 1382700000799 putative PBP binding loops; other site 1382700000800 ABC-ATPase subunit interface; other site 1382700000801 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 1382700000802 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1382700000803 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1382700000804 substrate binding pocket [chemical binding]; other site 1382700000805 membrane-bound complex binding site; other site 1382700000806 hinge residues; other site 1382700000807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1382700000808 dimer interface [polypeptide binding]; other site 1382700000809 conserved gate region; other site 1382700000810 putative PBP binding loops; other site 1382700000811 ABC-ATPase subunit interface; other site 1382700000812 hypothetical protein; Provisional; Region: PRK02877 1382700000813 hybrid cluster protein; Provisional; Region: PRK05290 1382700000814 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1382700000815 ACS interaction site; other site 1382700000816 CODH interaction site; other site 1382700000817 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 1382700000818 hybrid metal cluster; other site 1382700000819 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1382700000820 amphipathic channel; other site 1382700000821 Asn-Pro-Ala signature motifs; other site 1382700000822 Protein of unknown function (DUF535); Region: DUF535; pfam04393 1382700000823 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1382700000824 DNA-binding site [nucleotide binding]; DNA binding site 1382700000825 RNA-binding motif; other site 1382700000826 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1382700000827 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1382700000828 Clp amino terminal domain; Region: Clp_N; pfam02861 1382700000829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1382700000830 Walker A motif; other site 1382700000831 ATP binding site [chemical binding]; other site 1382700000832 Walker B motif; other site 1382700000833 arginine finger; other site 1382700000834 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1382700000835 Walker A motif; other site 1382700000836 ATP binding site [chemical binding]; other site 1382700000837 Walker B motif; other site 1382700000838 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1382700000839 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1382700000840 rRNA binding site [nucleotide binding]; other site 1382700000841 predicted 30S ribosome binding site; other site 1382700000842 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1382700000843 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1382700000844 putative DNA binding site [nucleotide binding]; other site 1382700000845 putative Zn2+ binding site [ion binding]; other site 1382700000846 AsnC family; Region: AsnC_trans_reg; pfam01037 1382700000847 periplasmic chaperone LolA; Region: lolA; TIGR00547 1382700000848 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1382700000849 seryl-tRNA synthetase; Provisional; Region: PRK05431 1382700000850 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1382700000851 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1382700000852 dimer interface [polypeptide binding]; other site 1382700000853 active site 1382700000854 motif 1; other site 1382700000855 motif 2; other site 1382700000856 motif 3; other site 1382700000857 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1382700000858 4Fe-4S binding domain; Region: Fer4; pfam00037 1382700000859 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 1382700000860 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1382700000861 FeS/SAM binding site; other site 1382700000862 cytidylate kinase; Provisional; Region: cmk; PRK00023 1382700000863 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1382700000864 CMP-binding site; other site 1382700000865 The sites determining sugar specificity; other site 1382700000866 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1382700000867 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1382700000868 RNA binding site [nucleotide binding]; other site 1382700000869 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1382700000870 RNA binding site [nucleotide binding]; other site 1382700000871 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1382700000872 RNA binding site [nucleotide binding]; other site 1382700000873 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1382700000874 RNA binding site [nucleotide binding]; other site 1382700000875 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1382700000876 RNA binding site [nucleotide binding]; other site 1382700000877 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1382700000878 IHF dimer interface [polypeptide binding]; other site 1382700000879 IHF - DNA interface [nucleotide binding]; other site 1382700000880 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 1382700000881 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1382700000882 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1382700000883 Walker A/P-loop; other site 1382700000884 ATP binding site [chemical binding]; other site 1382700000885 Q-loop/lid; other site 1382700000886 ABC transporter signature motif; other site 1382700000887 Walker B; other site 1382700000888 D-loop; other site 1382700000889 H-loop/switch region; other site 1382700000890 hypothetical protein; Provisional; Region: PRK11827 1382700000891 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1382700000892 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1382700000893 putative active site [active] 1382700000894 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1382700000895 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1382700000896 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1382700000897 putative dimer interface [polypeptide binding]; other site 1382700000898 putative anticodon binding site; other site 1382700000899 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1382700000900 homodimer interface [polypeptide binding]; other site 1382700000901 motif 1; other site 1382700000902 motif 2; other site 1382700000903 active site 1382700000904 motif 3; other site 1382700000905 ribosome modulation factor; Provisional; Region: PRK14563 1382700000906 outer membrane protein A; Reviewed; Region: PRK10808 1382700000907 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 1382700000908 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1382700000909 ligand binding site [chemical binding]; other site 1382700000910 hypothetical protein; Provisional; Region: PRK03641 1382700000911 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 1382700000912 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1382700000913 heat shock protein HspQ; Provisional; Region: PRK14129 1382700000914 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1382700000915 sulfur transfer protein TusE; Provisional; Region: PRK11508 1382700000916 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1382700000917 YccA-like proteins; Region: YccA_like; cd10433 1382700000918 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 1382700000919 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 1382700000920 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1382700000921 GnsA/GnsB family; Region: GnsAB; pfam08178 1382700000922 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 1382700000923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1382700000924 active site 1382700000925 phosphorylation site [posttranslational modification] 1382700000926 intermolecular recognition site; other site 1382700000927 dimerization interface [polypeptide binding]; other site 1382700000928 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1382700000929 DNA binding site [nucleotide binding] 1382700000930 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1382700000931 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1382700000932 HSP70 interaction site [polypeptide binding]; other site 1382700000933 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1382700000934 substrate binding site [polypeptide binding]; other site 1382700000935 dimer interface [polypeptide binding]; other site 1382700000936 hypothetical protein; Provisional; Region: PRK10174 1382700000937 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1382700000938 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1382700000939 General stress protein [General function prediction only]; Region: GsiB; COG3729 1382700000940 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1382700000941 homotrimer interaction site [polypeptide binding]; other site 1382700000942 putative active site [active] 1382700000943 N-glycosyltransferase; Provisional; Region: PRK11204 1382700000944 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1382700000945 DXD motif; other site 1382700000946 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1382700000947 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 1382700000948 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 1382700000949 putative active site [active] 1382700000950 Fimbrial protein; Region: Fimbrial; cl01416 1382700000951 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1382700000952 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1382700000953 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1382700000954 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1382700000955 homodimer interface [polypeptide binding]; other site 1382700000956 active site 1382700000957 TDP-binding site; other site 1382700000958 acceptor substrate-binding pocket; other site 1382700000959 Protein of unknown function (DUF987); Region: DUF987; pfam06174 1382700000960 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 1382700000961 curli assembly protein CsgF; Provisional; Region: PRK10050 1382700000962 curli assembly protein CsgE; Provisional; Region: PRK10386 1382700000963 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 1382700000964 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1382700000965 DNA binding residues [nucleotide binding] 1382700000966 dimerization interface [polypeptide binding]; other site 1382700000967 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 1382700000968 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 1382700000969 DNA damage-inducible protein I; Provisional; Region: PRK10597 1382700000970 lipoprotein; Provisional; Region: PRK10598 1382700000971 glutaredoxin 2; Provisional; Region: PRK10387 1382700000972 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 1382700000973 C-terminal domain interface [polypeptide binding]; other site 1382700000974 GSH binding site (G-site) [chemical binding]; other site 1382700000975 catalytic residues [active] 1382700000976 putative dimer interface [polypeptide binding]; other site 1382700000977 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 1382700000978 N-terminal domain interface [polypeptide binding]; other site 1382700000979 hypothetical protein; Provisional; Region: PRK11239 1382700000980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 1382700000981 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1382700000982 MviN-like protein; Region: MVIN; pfam03023 1382700000983 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 1382700000984 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1382700000985 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1382700000986 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1382700000987 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1382700000988 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1382700000989 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1382700000990 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1382700000991 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1382700000992 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1382700000993 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 1382700000994 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1382700000995 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1382700000996 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1382700000997 RNA binding surface [nucleotide binding]; other site 1382700000998 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1382700000999 active site 1382700001000 hypothetical protein; Provisional; Region: PRK11193 1382700001001 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1382700001002 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1382700001003 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1382700001004 dimer interface [polypeptide binding]; other site 1382700001005 active site 1382700001006 CoA binding pocket [chemical binding]; other site 1382700001007 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1382700001008 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1382700001009 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1382700001010 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1382700001011 NAD(P) binding site [chemical binding]; other site 1382700001012 homotetramer interface [polypeptide binding]; other site 1382700001013 homodimer interface [polypeptide binding]; other site 1382700001014 active site 1382700001015 acyl carrier protein; Provisional; Region: acpP; PRK00982 1382700001016 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1382700001017 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1382700001018 dimer interface [polypeptide binding]; other site 1382700001019 active site 1382700001020 conserved hypothetical protein, YceG family; Region: TIGR00247 1382700001021 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1382700001022 dimerization interface [polypeptide binding]; other site 1382700001023 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1382700001024 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1382700001025 active site 1382700001026 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 1382700001027 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1382700001028 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1382700001029 active site turn [active] 1382700001030 phosphorylation site [posttranslational modification] 1382700001031 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 1382700001032 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1382700001033 N-terminal plug; other site 1382700001034 ligand-binding site [chemical binding]; other site 1382700001035 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 1382700001036 hypothetical protein; Provisional; Region: PRK04940 1382700001037 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 1382700001038 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1382700001039 Walker A/P-loop; other site 1382700001040 ATP binding site [chemical binding]; other site 1382700001041 Q-loop/lid; other site 1382700001042 ABC transporter signature motif; other site 1382700001043 Walker B; other site 1382700001044 D-loop; other site 1382700001045 H-loop/switch region; other site 1382700001046 NAD-dependent deacetylase; Provisional; Region: PRK00481 1382700001047 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1382700001048 NAD+ binding site [chemical binding]; other site 1382700001049 substrate binding site [chemical binding]; other site 1382700001050 Zn binding site [ion binding]; other site 1382700001051 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1382700001052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1382700001053 dimer interface [polypeptide binding]; other site 1382700001054 conserved gate region; other site 1382700001055 putative PBP binding loops; other site 1382700001056 ABC-ATPase subunit interface; other site 1382700001057 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1382700001058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1382700001059 dimer interface [polypeptide binding]; other site 1382700001060 conserved gate region; other site 1382700001061 putative PBP binding loops; other site 1382700001062 ABC-ATPase subunit interface; other site 1382700001063 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1382700001064 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1382700001065 metal binding site [ion binding]; metal-binding site 1382700001066 dimer interface [polypeptide binding]; other site 1382700001067 sensor protein PhoQ; Provisional; Region: PRK10815 1382700001068 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 1382700001069 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1382700001070 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1382700001071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1382700001072 ATP binding site [chemical binding]; other site 1382700001073 Mg2+ binding site [ion binding]; other site 1382700001074 G-X-G motif; other site 1382700001075 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1382700001076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1382700001077 active site 1382700001078 phosphorylation site [posttranslational modification] 1382700001079 intermolecular recognition site; other site 1382700001080 dimerization interface [polypeptide binding]; other site 1382700001081 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1382700001082 DNA binding site [nucleotide binding] 1382700001083 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 1382700001084 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 1382700001085 Protein of unknown function (DUF2528); Region: DUF2528; pfam10800 1382700001086 Antirestriction protein Ral; Region: Ral; pfam11058 1382700001087 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1382700001088 non-specific DNA binding site [nucleotide binding]; other site 1382700001089 salt bridge; other site 1382700001090 sequence-specific DNA binding site [nucleotide binding]; other site 1382700001091 Protein of unknown function (DUF2591); Region: DUF2591; cl11584 1382700001092 endodeoxyribonuclease RUS; Reviewed; Region: PRK09786 1382700001093 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 1382700001094 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1382700001095 tandem repeat interface [polypeptide binding]; other site 1382700001096 oligomer interface [polypeptide binding]; other site 1382700001097 active site residues [active] 1382700001098 DNA packaging protein FI; Region: Packaging_FI; pfam14000 1382700001099 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 1382700001100 Minor tail protein T; Region: Phage_tail_T; pfam06223 1382700001101 Phage-related protein [Function unknown]; Region: gp18; COG4672 1382700001102 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1382700001103 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1382700001104 ABC-ATPase subunit interface; other site 1382700001105 dimer interface [polypeptide binding]; other site 1382700001106 putative PBP binding regions; other site 1382700001107 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 1382700001108 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1382700001109 cell division inhibitor MinD; Provisional; Region: PRK10818 1382700001110 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1382700001111 Switch I; other site 1382700001112 Switch II; other site 1382700001113 septum formation inhibitor; Reviewed; Region: minC; PRK03511 1382700001114 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1382700001115 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1382700001116 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 1382700001117 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 1382700001118 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1382700001119 hypothetical protein; Provisional; Region: PRK10691 1382700001120 fatty acid metabolism regulator; Provisional; Region: PRK04984 1382700001121 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1382700001122 DNA-binding site [nucleotide binding]; DNA binding site 1382700001123 FadR C-terminal domain; Region: FadR_C; pfam07840 1382700001124 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 1382700001125 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1382700001126 TrkA-C domain; Region: TrkA_C; pfam02080 1382700001127 Transporter associated domain; Region: CorC_HlyC; smart01091 1382700001128 hypothetical protein; Provisional; Region: PRK10457 1382700001129 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1382700001130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1382700001131 S-adenosylmethionine binding site [chemical binding]; other site 1382700001132 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1382700001133 putative active site [active] 1382700001134 catalytic residue [active] 1382700001135 hypothetical protein; Provisional; Region: PRK10692 1382700001136 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1382700001137 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1382700001138 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1382700001139 active site 1382700001140 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1382700001141 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1382700001142 RF-1 domain; Region: RF-1; pfam00472 1382700001143 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1382700001144 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1382700001145 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1382700001146 cation transport regulator; Reviewed; Region: chaB; PRK09582 1382700001147 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 1382700001148 transcriptional regulator NarL; Provisional; Region: PRK10651 1382700001149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1382700001150 active site 1382700001151 phosphorylation site [posttranslational modification] 1382700001152 intermolecular recognition site; other site 1382700001153 dimerization interface [polypeptide binding]; other site 1382700001154 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1382700001155 DNA binding residues [nucleotide binding] 1382700001156 dimerization interface [polypeptide binding]; other site 1382700001157 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1382700001158 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1382700001159 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1382700001160 [4Fe-4S] binding site [ion binding]; other site 1382700001161 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1382700001162 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1382700001163 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1382700001164 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1382700001165 molybdopterin cofactor binding site; other site 1382700001166 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1382700001167 4Fe-4S binding domain; Region: Fer4; cl02805 1382700001168 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1382700001169 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1382700001170 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1382700001171 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1382700001172 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1382700001173 putative active site [active] 1382700001174 putative substrate binding site [chemical binding]; other site 1382700001175 putative cosubstrate binding site; other site 1382700001176 catalytic site [active] 1382700001177 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1382700001178 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1382700001179 active site 1382700001180 tetramer interface; other site 1382700001181 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1382700001182 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1382700001183 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1382700001184 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1382700001185 peptide binding site [polypeptide binding]; other site 1382700001186 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1382700001187 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1382700001188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1382700001189 dimer interface [polypeptide binding]; other site 1382700001190 conserved gate region; other site 1382700001191 putative PBP binding loops; other site 1382700001192 ABC-ATPase subunit interface; other site 1382700001193 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1382700001194 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1382700001195 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1382700001196 putative active site [active] 1382700001197 catalytic site [active] 1382700001198 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1382700001199 putative active site [active] 1382700001200 catalytic site [active] 1382700001201 YciI-like protein; Reviewed; Region: PRK11370 1382700001202 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1382700001203 DicB protein; Region: DicB; pfam05358 1382700001204 phage tail assembly protein T; Region: phage_lam_T; TIGR01715 1382700001205 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1382700001206 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1382700001207 substrate binding site [chemical binding]; other site 1382700001208 active site 1382700001209 catalytic residues [active] 1382700001210 heterodimer interface [polypeptide binding]; other site 1382700001211 hypothetical protein; Provisional; Region: PRK11630 1382700001212 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1382700001213 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1382700001214 RNA binding surface [nucleotide binding]; other site 1382700001215 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1382700001216 probable active site [active] 1382700001217 hypothetical protein; Provisional; Region: PRK11037 1382700001218 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1382700001219 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1382700001220 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 1382700001221 substrate binding site [chemical binding]; other site 1382700001222 putative dimerization interface [polypeptide binding]; other site 1382700001223 Predicted membrane protein [Function unknown]; Region: COG3771 1382700001224 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 1382700001225 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1382700001226 TPR motif; other site 1382700001227 binding surface 1382700001228 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1382700001229 binding surface 1382700001230 TPR motif; other site 1382700001231 lipoprotein; Provisional; Region: PRK10540 1382700001232 hypothetical protein; Provisional; Region: PRK13658 1382700001233 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 1382700001234 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1382700001235 NAD binding site [chemical binding]; other site 1382700001236 homotetramer interface [polypeptide binding]; other site 1382700001237 homodimer interface [polypeptide binding]; other site 1382700001238 substrate binding site [chemical binding]; other site 1382700001239 active site 1382700001240 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 1382700001241 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1382700001242 Walker A/P-loop; other site 1382700001243 ATP binding site [chemical binding]; other site 1382700001244 Q-loop/lid; other site 1382700001245 ABC transporter signature motif; other site 1382700001246 Walker B; other site 1382700001247 D-loop; other site 1382700001248 H-loop/switch region; other site 1382700001249 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 1382700001250 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1382700001251 Walker A/P-loop; other site 1382700001252 ATP binding site [chemical binding]; other site 1382700001253 Q-loop/lid; other site 1382700001254 ABC transporter signature motif; other site 1382700001255 Walker B; other site 1382700001256 D-loop; other site 1382700001257 H-loop/switch region; other site 1382700001258 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1382700001259 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 1382700001260 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1382700001261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1382700001262 dimer interface [polypeptide binding]; other site 1382700001263 conserved gate region; other site 1382700001264 putative PBP binding loops; other site 1382700001265 ABC-ATPase subunit interface; other site 1382700001266 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 1382700001267 phage shock protein PspA; Provisional; Region: PRK10698 1382700001268 phage shock protein B; Provisional; Region: pspB; PRK09458 1382700001269 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1382700001270 dimer interface [polypeptide binding]; other site 1382700001271 catalytic triad [active] 1382700001272 peroxidatic and resolving cysteines [active] 1382700001273 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 1382700001274 universal stress protein UspE; Provisional; Region: PRK11175 1382700001275 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1382700001276 Ligand Binding Site [chemical binding]; other site 1382700001277 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1382700001278 Ligand Binding Site [chemical binding]; other site 1382700001279 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1382700001280 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1382700001281 ligand binding site [chemical binding]; other site 1382700001282 flexible hinge region; other site 1382700001283 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1382700001284 putative switch regulator; other site 1382700001285 non-specific DNA interactions [nucleotide binding]; other site 1382700001286 DNA binding site [nucleotide binding] 1382700001287 sequence specific DNA binding site [nucleotide binding]; other site 1382700001288 putative cAMP binding site [chemical binding]; other site 1382700001289 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 1382700001290 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1382700001291 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1382700001292 DNA binding site [nucleotide binding] 1382700001293 active site 1382700001294 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1382700001295 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1382700001296 Cl binding site [ion binding]; other site 1382700001297 oligomer interface [polypeptide binding]; other site 1382700001298 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1382700001299 Ligand Binding Site [chemical binding]; other site 1382700001300 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1382700001301 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1382700001302 trimer interface [polypeptide binding]; other site 1382700001303 eyelet of channel; other site 1382700001304 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1382700001305 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1382700001306 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 1382700001307 tellurite resistance protein TehB; Provisional; Region: PRK11207 1382700001308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1382700001309 S-adenosylmethionine binding site [chemical binding]; other site 1382700001310 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1382700001311 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1382700001312 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1382700001313 tetrameric interface [polypeptide binding]; other site 1382700001314 NAD binding site [chemical binding]; other site 1382700001315 catalytic residues [active] 1382700001316 substrate binding site [chemical binding]; other site 1382700001317 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 1382700001318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1382700001319 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1382700001320 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1382700001321 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1382700001322 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1382700001323 non-specific DNA binding site [nucleotide binding]; other site 1382700001324 salt bridge; other site 1382700001325 sequence-specific DNA binding site [nucleotide binding]; other site 1382700001326 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 1382700001327 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 1382700001328 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1382700001329 putative arabinose transporter; Provisional; Region: PRK03545 1382700001330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1382700001331 putative substrate translocation pore; other site 1382700001332 inner membrane protein; Provisional; Region: PRK10995 1382700001333 hypothetical protein; Provisional; Region: PRK10106 1382700001334 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1382700001335 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1382700001336 DNA-binding site [nucleotide binding]; DNA binding site 1382700001337 UTRA domain; Region: UTRA; pfam07702 1382700001338 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1382700001339 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1382700001340 DNA-binding site [nucleotide binding]; DNA binding site 1382700001341 FCD domain; Region: FCD; pfam07729 1382700001342 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 1382700001343 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1382700001344 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1382700001345 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1382700001346 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 1382700001347 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1382700001348 Coenzyme A binding pocket [chemical binding]; other site 1382700001349 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1382700001350 4Fe-4S binding domain; Region: Fer4; cl02805 1382700001351 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1382700001352 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1382700001353 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1382700001354 dimerization interface [polypeptide binding]; other site 1382700001355 substrate binding pocket [chemical binding]; other site 1382700001356 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1382700001357 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 1382700001358 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 1382700001359 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 1382700001360 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1382700001361 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1382700001362 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1382700001363 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1382700001364 sensor protein RstB; Provisional; Region: PRK10604 1382700001365 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1382700001366 dimerization interface [polypeptide binding]; other site 1382700001367 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1382700001368 dimer interface [polypeptide binding]; other site 1382700001369 phosphorylation site [posttranslational modification] 1382700001370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1382700001371 ATP binding site [chemical binding]; other site 1382700001372 Mg2+ binding site [ion binding]; other site 1382700001373 G-X-G motif; other site 1382700001374 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 1382700001375 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 1382700001376 NAD binding site [chemical binding]; other site 1382700001377 substrate binding site [chemical binding]; other site 1382700001378 homotetramer interface [polypeptide binding]; other site 1382700001379 homodimer interface [polypeptide binding]; other site 1382700001380 active site 1382700001381 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1382700001382 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1382700001383 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1382700001384 homodimer interface [polypeptide binding]; other site 1382700001385 catalytic residue [active] 1382700001386 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1382700001387 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1382700001388 active site 1382700001389 purine riboside binding site [chemical binding]; other site 1382700001390 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 1382700001391 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 1382700001392 electron transport complex protein RnfB; Provisional; Region: PRK05113 1382700001393 Putative Fe-S cluster; Region: FeS; pfam04060 1382700001394 4Fe-4S binding domain; Region: Fer4; pfam00037 1382700001395 electron transport complex protein RnfG; Validated; Region: PRK01908 1382700001396 endonuclease III; Provisional; Region: PRK10702 1382700001397 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1382700001398 minor groove reading motif; other site 1382700001399 helix-hairpin-helix signature motif; other site 1382700001400 substrate binding pocket [chemical binding]; other site 1382700001401 active site 1382700001402 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1382700001403 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 1382700001404 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1382700001405 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1382700001406 dimer interface [polypeptide binding]; other site 1382700001407 catalytic site [active] 1382700001408 putative active site [active] 1382700001409 putative substrate binding site [chemical binding]; other site 1382700001410 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1382700001411 putative GSH binding site [chemical binding]; other site 1382700001412 catalytic residues [active] 1382700001413 superoxide dismutase; Provisional; Region: PRK10543 1382700001414 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1382700001415 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1382700001416 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1382700001417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1382700001418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1382700001419 S-adenosylmethionine binding site [chemical binding]; other site 1382700001420 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 1382700001421 Lumazine binding domain; Region: Lum_binding; pfam00677 1382700001422 Lumazine binding domain; Region: Lum_binding; pfam00677 1382700001423 multidrug efflux protein; Reviewed; Region: PRK01766 1382700001424 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1382700001425 cation binding site [ion binding]; other site 1382700001426 hypothetical protein; Provisional; Region: PRK10292 1382700001427 murein lipoprotein; Provisional; Region: PRK15396 1382700001428 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1382700001429 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1382700001430 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1382700001431 catalytic residue [active] 1382700001432 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 1382700001433 putative inner membrane protein; Provisional; Region: PRK10983 1382700001434 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1382700001435 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1382700001436 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1382700001437 active site 1382700001438 catalytic residue [active] 1382700001439 dimer interface [polypeptide binding]; other site 1382700001440 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 1382700001441 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1382700001442 active site 1382700001443 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1382700001444 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 1382700001445 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1382700001446 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 1382700001447 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1382700001448 Walker A/P-loop; other site 1382700001449 ATP binding site [chemical binding]; other site 1382700001450 Q-loop/lid; other site 1382700001451 ABC transporter signature motif; other site 1382700001452 Walker B; other site 1382700001453 D-loop; other site 1382700001454 H-loop/switch region; other site 1382700001455 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1382700001456 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1382700001457 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1382700001458 dimer interface [polypeptide binding]; other site 1382700001459 motif 1; other site 1382700001460 active site 1382700001461 motif 2; other site 1382700001462 motif 3; other site 1382700001463 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1382700001464 23S rRNA binding site [nucleotide binding]; other site 1382700001465 L21 binding site [polypeptide binding]; other site 1382700001466 L13 binding site [polypeptide binding]; other site 1382700001467 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1382700001468 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1382700001469 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1382700001470 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1382700001471 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 1382700001472 Phosphotransferase enzyme family; Region: APH; pfam01636 1382700001473 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1382700001474 active site 1382700001475 ATP binding site [chemical binding]; other site 1382700001476 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1382700001477 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1382700001478 active site 1382700001479 P-loop; other site 1382700001480 phosphorylation site [posttranslational modification] 1382700001481 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 1382700001482 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 1382700001483 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1382700001484 GIY-YIG motif/motif A; other site 1382700001485 active site 1382700001486 catalytic site [active] 1382700001487 putative DNA binding site [nucleotide binding]; other site 1382700001488 metal binding site [ion binding]; metal-binding site 1382700001489 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 1382700001490 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1382700001491 putative active site [active] 1382700001492 Zn binding site [ion binding]; other site 1382700001493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1382700001494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1382700001495 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 1382700001496 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1382700001497 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1382700001498 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1382700001499 PrkA family serine protein kinase; Provisional; Region: PRK15455 1382700001500 AAA ATPase domain; Region: AAA_16; pfam13191 1382700001501 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1382700001502 Predicted membrane protein [Function unknown]; Region: COG2707 1382700001503 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1382700001504 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1382700001505 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1382700001506 hypothetical protein; Provisional; Region: PRK10457 1382700001507 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 1382700001508 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 1382700001509 hypothetical protein; Provisional; Region: PRK05114 1382700001510 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1382700001511 putative active site [active] 1382700001512 putative CoA binding site [chemical binding]; other site 1382700001513 nudix motif; other site 1382700001514 metal binding site [ion binding]; metal-binding site 1382700001515 L-serine deaminase; Provisional; Region: PRK15023 1382700001516 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1382700001517 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1382700001518 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1382700001519 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1382700001520 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1382700001521 Transporter associated domain; Region: CorC_HlyC; smart01091 1382700001522 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1382700001523 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 1382700001524 hypothetical protein; Provisional; Region: PRK11469 1382700001525 Domain of unknown function DUF; Region: DUF204; pfam02659 1382700001526 Domain of unknown function DUF; Region: DUF204; pfam02659 1382700001527 YebO-like protein; Region: YebO; pfam13974 1382700001528 YobH-like protein; Region: YobH; pfam13996 1382700001529 heat shock protein HtpX; Provisional; Region: PRK05457 1382700001530 ProP expression regulator; Provisional; Region: PRK04950 1382700001531 ProQ/FINO family; Region: ProQ; pfam04352 1382700001532 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 1382700001533 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 1382700001534 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 1382700001535 exodeoxyribonuclease X; Provisional; Region: PRK07983 1382700001536 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1382700001537 active site 1382700001538 catalytic site [active] 1382700001539 substrate binding site [chemical binding]; other site 1382700001540 hypothetical protein; Provisional; Region: PRK13680 1382700001541 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 1382700001542 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1382700001543 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1382700001544 active site 1382700001545 intersubunit interface [polypeptide binding]; other site 1382700001546 catalytic residue [active] 1382700001547 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1382700001548 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1382700001549 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1382700001550 putative active site [active] 1382700001551 putative peptidase; Provisional; Region: PRK11649 1382700001552 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 1382700001553 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1382700001554 Peptidase family M23; Region: Peptidase_M23; pfam01551 1382700001555 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1382700001556 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1382700001557 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1382700001558 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1382700001559 Walker A motif; other site 1382700001560 ATP binding site [chemical binding]; other site 1382700001561 Walker B motif; other site 1382700001562 arginine finger; other site 1382700001563 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1382700001564 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1382700001565 RuvA N terminal domain; Region: RuvA_N; pfam01330 1382700001566 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1382700001567 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1382700001568 active site 1382700001569 putative DNA-binding cleft [nucleotide binding]; other site 1382700001570 dimer interface [polypeptide binding]; other site 1382700001571 hypothetical protein; Validated; Region: PRK00110 1382700001572 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1382700001573 nudix motif; other site 1382700001574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1382700001575 S-adenosylmethionine binding site [chemical binding]; other site 1382700001576 chemotaxis regulator CheZ; Provisional; Region: PRK11166 1382700001577 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1382700001578 putative CheA interaction surface; other site 1382700001579 transcriptional activator FlhC; Provisional; Region: PRK12722 1382700001580 transcriptional activator FlhD; Provisional; Region: PRK02909 1382700001581 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1382700001582 Ligand Binding Site [chemical binding]; other site 1382700001583 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1382700001584 Ferritin-like domain; Region: Ferritin; pfam00210 1382700001585 ferroxidase diiron center [ion binding]; other site 1382700001586 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 1382700001587 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1382700001588 Ferritin-like domain; Region: Ferritin; pfam00210 1382700001589 ferroxidase diiron center [ion binding]; other site 1382700001590 hypothetical protein; Provisional; Region: PRK10396 1382700001591 yecA family protein; Region: ygfB_yecA; TIGR02292 1382700001592 SEC-C motif; Region: SEC-C; pfam02810 1382700001593 response regulator; Provisional; Region: PRK09483 1382700001594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1382700001595 active site 1382700001596 phosphorylation site [posttranslational modification] 1382700001597 intermolecular recognition site; other site 1382700001598 dimerization interface [polypeptide binding]; other site 1382700001599 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1382700001600 DNA binding residues [nucleotide binding] 1382700001601 dimerization interface [polypeptide binding]; other site 1382700001602 hypothetical protein; Provisional; Region: PRK10613 1382700001603 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1382700001604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1382700001605 dimer interface [polypeptide binding]; other site 1382700001606 conserved gate region; other site 1382700001607 putative PBP binding loops; other site 1382700001608 ABC-ATPase subunit interface; other site 1382700001609 Flagellar protein FliS; Region: FliS; cl00654 1382700001610 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 1382700001611 CPxP motif; other site 1382700001612 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1382700001613 substrate binding site [chemical binding]; other site 1382700001614 multidrug efflux protein; Reviewed; Region: emrE; PRK09541 1382700001615 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1382700001616 FliG C-terminal domain; Region: FliG_C; pfam01706 1382700001617 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 1382700001618 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1382700001619 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1382700001620 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1382700001621 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1382700001622 hypothetical protein; Provisional; Region: PRK10708 1382700001623 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 1382700001624 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1382700001625 EamA-like transporter family; Region: EamA; pfam00892 1382700001626 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1382700001627 active site 1382700001628 homotetramer interface [polypeptide binding]; other site 1382700001629 integrase; Provisional; Region: PRK09692 1382700001630 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1382700001631 active site 1382700001632 Int/Topo IB signature motif; other site 1382700001633 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 1382700001634 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1382700001635 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_6; cd13146 1382700001636 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1382700001637 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1382700001638 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1382700001639 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1382700001640 putative trimer interface [polypeptide binding]; other site 1382700001641 putative CoA binding site [chemical binding]; other site 1382700001642 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1382700001643 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1382700001644 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1382700001645 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1382700001646 active site 1382700001647 substrate binding pocket [chemical binding]; other site 1382700001648 homodimer interaction site [polypeptide binding]; other site 1382700001649 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 1382700001650 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1382700001651 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1382700001652 N-terminal plug; other site 1382700001653 ligand-binding site [chemical binding]; other site 1382700001654 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1382700001655 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1382700001656 nucleophile elbow; other site 1382700001657 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1382700001658 hypothetical protein; Provisional; Region: PRK05423 1382700001659 DNA gyrase inhibitor; Provisional; Region: PRK10016 1382700001660 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1382700001661 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1382700001662 putative NAD(P) binding site [chemical binding]; other site 1382700001663 antitoxin YefM; Provisional; Region: PRK11409 1382700001664 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1382700001665 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1382700001666 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1382700001667 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1382700001668 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1382700001669 NAD binding site [chemical binding]; other site 1382700001670 dimerization interface [polypeptide binding]; other site 1382700001671 product binding site; other site 1382700001672 substrate binding site [chemical binding]; other site 1382700001673 zinc binding site [ion binding]; other site 1382700001674 catalytic residues [active] 1382700001675 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 1382700001676 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1382700001677 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1382700001678 homodimer interface [polypeptide binding]; other site 1382700001679 catalytic residue [active] 1382700001680 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 1382700001681 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1382700001682 putative active site [active] 1382700001683 oxyanion strand; other site 1382700001684 catalytic triad [active] 1382700001685 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1382700001686 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1382700001687 substrate binding site [chemical binding]; other site 1382700001688 glutamase interaction surface [polypeptide binding]; other site 1382700001689 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 1382700001690 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1382700001691 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 1382700001692 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1382700001693 Substrate binding site; other site 1382700001694 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1382700001695 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1382700001696 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1382700001697 NADP binding site [chemical binding]; other site 1382700001698 active site 1382700001699 putative substrate binding site [chemical binding]; other site 1382700001700 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1382700001701 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1382700001702 NADP-binding site; other site 1382700001703 homotetramer interface [polypeptide binding]; other site 1382700001704 substrate binding site [chemical binding]; other site 1382700001705 homodimer interface [polypeptide binding]; other site 1382700001706 active site 1382700001707 putative acyl transferase; Provisional; Region: PRK10191 1382700001708 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1382700001709 trimer interface [polypeptide binding]; other site 1382700001710 active site 1382700001711 substrate binding site [chemical binding]; other site 1382700001712 CoA binding site [chemical binding]; other site 1382700001713 polysaccharide export protein Wza; Provisional; Region: PRK15078 1382700001714 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1382700001715 SLBB domain; Region: SLBB; pfam10531 1382700001716 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 1382700001717 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1382700001718 trimer interface [polypeptide binding]; other site 1382700001719 active site 1382700001720 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1382700001721 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1382700001722 ATP-binding site [chemical binding]; other site 1382700001723 Sugar specificity; other site 1382700001724 Pyrimidine base specificity; other site 1382700001725 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1382700001726 Protein export membrane protein; Region: SecD_SecF; cl14618 1382700001727 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 1382700001728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1382700001729 active site 1382700001730 phosphorylation site [posttranslational modification] 1382700001731 intermolecular recognition site; other site 1382700001732 dimerization interface [polypeptide binding]; other site 1382700001733 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1382700001734 DNA binding site [nucleotide binding] 1382700001735 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1382700001736 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1382700001737 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1382700001738 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 1382700001739 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1382700001740 putative active site; other site 1382700001741 catalytic residue [active] 1382700001742 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1382700001743 putative metal binding site [ion binding]; other site 1382700001744 putative homodimer interface [polypeptide binding]; other site 1382700001745 putative homotetramer interface [polypeptide binding]; other site 1382700001746 putative homodimer-homodimer interface [polypeptide binding]; other site 1382700001747 putative allosteric switch controlling residues; other site 1382700001748 Predicted integral membrane protein [Function unknown]; Region: COG5455 1382700001749 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 1382700001750 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1382700001751 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1382700001752 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 1382700001753 antiporter inner membrane protein; Provisional; Region: PRK11670 1382700001754 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1382700001755 Walker A motif; other site 1382700001756 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1382700001757 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1382700001758 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1382700001759 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1382700001760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1382700001761 active site 1382700001762 phosphorylation site [posttranslational modification] 1382700001763 intermolecular recognition site; other site 1382700001764 dimerization interface [polypeptide binding]; other site 1382700001765 LytTr DNA-binding domain; Region: LytTR; pfam04397 1382700001766 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1382700001767 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1382700001768 GAF domain; Region: GAF; pfam01590 1382700001769 Histidine kinase; Region: His_kinase; pfam06580 1382700001770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1382700001771 ATP binding site [chemical binding]; other site 1382700001772 Mg2+ binding site [ion binding]; other site 1382700001773 G-X-G motif; other site 1382700001774 hypothetical protein; Provisional; Region: PRK13681 1382700001775 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1382700001776 hypothetical protein; Provisional; Region: PRK01821 1382700001777 hypothetical protein; Provisional; Region: PRK10711 1382700001778 cytidine deaminase; Provisional; Region: PRK09027 1382700001779 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1382700001780 active site 1382700001781 catalytic motif [active] 1382700001782 Zn binding site [ion binding]; other site 1382700001783 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1382700001784 active site 1382700001785 catalytic motif [active] 1382700001786 Zn binding site [ion binding]; other site 1382700001787 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1382700001788 putative active site [active] 1382700001789 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 1382700001790 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 1382700001791 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 1382700001792 ligand binding site [chemical binding]; other site 1382700001793 calcium binding site [ion binding]; other site 1382700001794 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1382700001795 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1382700001796 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1382700001797 putative dimerization interface [polypeptide binding]; other site 1382700001798 conserved hypothetical integral membrane protein; Region: TIGR00698 1382700001799 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1382700001800 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1382700001801 putative substrate binding site [chemical binding]; other site 1382700001802 putative ATP binding site [chemical binding]; other site 1382700001803 Flagellin N-methylase; Region: FliB; pfam03692 1382700001804 elongation factor P; Provisional; Region: PRK04542 1382700001805 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1382700001806 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1382700001807 RNA binding site [nucleotide binding]; other site 1382700001808 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1382700001809 RNA binding site [nucleotide binding]; other site 1382700001810 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 1382700001811 NlpC/P60 family; Region: NLPC_P60; pfam00877 1382700001812 hypothetical protein; Provisional; Region: PRK11835 1382700001813 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1382700001814 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1382700001815 RNA binding surface [nucleotide binding]; other site 1382700001816 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1382700001817 active site 1382700001818 uracil binding [chemical binding]; other site 1382700001819 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1382700001820 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1382700001821 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 1382700001822 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 1382700001823 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1382700001824 binding surface 1382700001825 TPR motif; other site 1382700001826 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 1382700001827 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1382700001828 catalytic residues [active] 1382700001829 central insert; other site 1382700001830 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 1382700001831 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1382700001832 heme exporter protein CcmC; Region: ccmC; TIGR01191 1382700001833 cytochrome c-type protein NapC; Provisional; Region: PRK10617 1382700001834 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 1382700001835 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 1382700001836 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1382700001837 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1382700001838 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 1382700001839 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 1382700001840 ferredoxin-type protein; Provisional; Region: PRK10194 1382700001841 malate:quinone oxidoreductase; Validated; Region: PRK05257 1382700001842 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1382700001843 transcriptional regulator RcsB; Provisional; Region: PRK10840 1382700001844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1382700001845 active site 1382700001846 phosphorylation site [posttranslational modification] 1382700001847 intermolecular recognition site; other site 1382700001848 dimerization interface [polypeptide binding]; other site 1382700001849 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1382700001850 DNA binding residues [nucleotide binding] 1382700001851 dimerization interface [polypeptide binding]; other site 1382700001852 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 1382700001853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1382700001854 active site 1382700001855 phosphorylation site [posttranslational modification] 1382700001856 intermolecular recognition site; other site 1382700001857 dimerization interface [polypeptide binding]; other site 1382700001858 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1382700001859 Walker A motif; other site 1382700001860 ATP binding site [chemical binding]; other site 1382700001861 Walker B motif; other site 1382700001862 arginine finger; other site 1382700001863 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1382700001864 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1382700001865 Short chain fatty acid transporter; Region: SCFA_trans; pfam02667 1382700001866 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 1382700001867 ATP cone domain; Region: ATP-cone; pfam03477 1382700001868 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1382700001869 active site 1382700001870 dimer interface [polypeptide binding]; other site 1382700001871 catalytic residues [active] 1382700001872 effector binding site; other site 1382700001873 R2 peptide binding site; other site 1382700001874 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1382700001875 dimer interface [polypeptide binding]; other site 1382700001876 putative radical transfer pathway; other site 1382700001877 diiron center [ion binding]; other site 1382700001878 tyrosyl radical; other site 1382700001879 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1382700001880 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1382700001881 catalytic loop [active] 1382700001882 iron binding site [ion binding]; other site 1382700001883 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1382700001884 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 1382700001885 active site 1382700001886 catalytic site [active] 1382700001887 metal binding site [ion binding]; metal-binding site 1382700001888 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 1382700001889 hypothetical protein; Provisional; Region: PRK03673 1382700001890 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1382700001891 putative MPT binding site; other site 1382700001892 Competence-damaged protein; Region: CinA; cl00666 1382700001893 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1382700001894 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1382700001895 substrate binding site [chemical binding]; other site 1382700001896 oxyanion hole (OAH) forming residues; other site 1382700001897 trimer interface [polypeptide binding]; other site 1382700001898 hypothetical protein; Provisional; Region: PRK10404 1382700001899 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1382700001900 Coenzyme A binding pocket [chemical binding]; other site 1382700001901 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1382700001902 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1382700001903 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1382700001904 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1382700001905 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1382700001906 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1382700001907 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1382700001908 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1382700001909 4Fe-4S binding domain; Region: Fer4; pfam00037 1382700001910 4Fe-4S binding domain; Region: Fer4; pfam00037 1382700001911 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1382700001912 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1382700001913 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1382700001914 putative dimer interface [polypeptide binding]; other site 1382700001915 [2Fe-2S] cluster binding site [ion binding]; other site 1382700001916 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1382700001917 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1382700001918 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1382700001919 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1382700001920 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1382700001921 aminotransferase AlaT; Validated; Region: PRK09265 1382700001922 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1382700001923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1382700001924 homodimer interface [polypeptide binding]; other site 1382700001925 catalytic residue [active] 1382700001926 5'-nucleotidase; Provisional; Region: PRK03826 1382700001927 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1382700001928 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1382700001929 TrkA-C domain; Region: TrkA_C; pfam02080 1382700001930 TrkA-C domain; Region: TrkA_C; pfam02080 1382700001931 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1382700001932 hypothetical protein; Validated; Region: PRK05445 1382700001933 propionate/acetate kinase; Provisional; Region: PRK12379 1382700001934 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1382700001935 phosphate acetyltransferase; Reviewed; Region: PRK05632 1382700001936 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1382700001937 DRTGG domain; Region: DRTGG; pfam07085 1382700001938 phosphate acetyltransferase; Region: pta; TIGR00651 1382700001939 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 1382700001940 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 1382700001941 nudix motif; other site 1382700001942 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1382700001943 homooctamer interface [polypeptide binding]; other site 1382700001944 active site 1382700001945 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 1382700001946 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1382700001947 Walker A/P-loop; other site 1382700001948 ATP binding site [chemical binding]; other site 1382700001949 Q-loop/lid; other site 1382700001950 ABC transporter signature motif; other site 1382700001951 Walker B; other site 1382700001952 D-loop; other site 1382700001953 H-loop/switch region; other site 1382700001954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1382700001955 dimer interface [polypeptide binding]; other site 1382700001956 conserved gate region; other site 1382700001957 putative PBP binding loops; other site 1382700001958 ABC-ATPase subunit interface; other site 1382700001959 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1382700001960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1382700001961 dimer interface [polypeptide binding]; other site 1382700001962 conserved gate region; other site 1382700001963 putative PBP binding loops; other site 1382700001964 ABC-ATPase subunit interface; other site 1382700001965 cell division protein DedD; Provisional; Region: PRK11633 1382700001966 Sporulation related domain; Region: SPOR; pfam05036 1382700001967 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1382700001968 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1382700001969 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1382700001970 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1382700001971 dimer interface [polypeptide binding]; other site 1382700001972 active site 1382700001973 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 1382700001974 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 1382700001975 hypothetical protein; Provisional; Region: PRK04946 1382700001976 Smr domain; Region: Smr; pfam01713 1382700001977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 1382700001978 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 1382700001979 integrase; Provisional; Region: PRK09692 1382700001980 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1382700001981 active site 1382700001982 Int/Topo IB signature motif; other site 1382700001983 Protein of unknown function (DUF2560); Region: DUF2560; pfam10834 1382700001984 Phage NinH protein; Region: Phage_NinH; pfam06322 1382700001985 Endodeoxyribonuclease RusA; Region: RusA; cl01885 1382700001986 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 1382700001987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1382700001988 active site 1382700001989 phosphorylation site [posttranslational modification] 1382700001990 intermolecular recognition site; other site 1382700001991 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1382700001992 DNA binding residues [nucleotide binding] 1382700001993 dimerization interface [polypeptide binding]; other site 1382700001994 putative transporter YfdV; Provisional; Region: PRK09903 1382700001995 formyl-coenzyme A transferase; Provisional; Region: PRK05398 1382700001996 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1382700001997 hypothetical protein; Provisional; Region: PRK10316 1382700001998 YfdX protein; Region: YfdX; pfam10938 1382700001999 manganese transport protein MntH; Reviewed; Region: PRK00701 1382700002000 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1382700002001 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1382700002002 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1382700002003 Nucleoside recognition; Region: Gate; pfam07670 1382700002004 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1382700002005 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1382700002006 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1382700002007 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1382700002008 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1382700002009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 1382700002010 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1382700002011 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1382700002012 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1382700002013 dimer interface [polypeptide binding]; other site 1382700002014 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1382700002015 catalytic residue [active] 1382700002016 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1382700002017 dimerization domain swap beta strand [polypeptide binding]; other site 1382700002018 regulatory protein interface [polypeptide binding]; other site 1382700002019 active site 1382700002020 regulatory phosphorylation site [posttranslational modification]; other site 1382700002021 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1382700002022 HPr interaction site; other site 1382700002023 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1382700002024 active site 1382700002025 phosphorylation site [posttranslational modification] 1382700002026 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1382700002027 dimer interface [polypeptide binding]; other site 1382700002028 pyridoxamine kinase; Validated; Region: PRK05756 1382700002029 pyridoxal binding site [chemical binding]; other site 1382700002030 ATP binding site [chemical binding]; other site 1382700002031 short chain dehydrogenase; Provisional; Region: PRK08226 1382700002032 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 1382700002033 NAD binding site [chemical binding]; other site 1382700002034 homotetramer interface [polypeptide binding]; other site 1382700002035 homodimer interface [polypeptide binding]; other site 1382700002036 active site 1382700002037 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1382700002038 putative acetyltransferase; Provisional; Region: PRK03624 1382700002039 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1382700002040 Coenzyme A binding pocket [chemical binding]; other site 1382700002041 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 1382700002042 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 1382700002043 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1382700002044 nucleotide binding site [chemical binding]; other site 1382700002045 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1382700002046 Hexamer/Pentamer interface [polypeptide binding]; other site 1382700002047 central pore; other site 1382700002048 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1382700002049 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1382700002050 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1382700002051 putative NAD(P) binding site [chemical binding]; other site 1382700002052 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1382700002053 hypothetical protein; Provisional; Region: PRK13664 1382700002054 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1382700002055 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1382700002056 ATP binding site [chemical binding]; other site 1382700002057 active site 1382700002058 substrate binding site [chemical binding]; other site 1382700002059 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1382700002060 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1382700002061 dimer interface [polypeptide binding]; other site 1382700002062 active site 1382700002063 catalytic residue [active] 1382700002064 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 1382700002065 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 1382700002066 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1382700002067 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1382700002068 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1382700002069 catalytic triad [active] 1382700002070 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1382700002071 DNA replication initiation factor; Provisional; Region: PRK08084 1382700002072 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1382700002073 active site 1382700002074 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1382700002075 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1382700002076 active site 1382700002077 substrate binding site [chemical binding]; other site 1382700002078 cosubstrate binding site; other site 1382700002079 catalytic site [active] 1382700002080 exopolyphosphatase; Provisional; Region: PRK10854 1382700002081 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1382700002082 MASE1; Region: MASE1; pfam05231 1382700002083 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1382700002084 diguanylate cyclase; Region: GGDEF; smart00267 1382700002085 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1382700002086 GMP synthase; Reviewed; Region: guaA; PRK00074 1382700002087 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1382700002088 AMP/PPi binding site [chemical binding]; other site 1382700002089 candidate oxyanion hole; other site 1382700002090 catalytic triad [active] 1382700002091 potential glutamine specificity residues [chemical binding]; other site 1382700002092 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1382700002093 ATP Binding subdomain [chemical binding]; other site 1382700002094 Ligand Binding sites [chemical binding]; other site 1382700002095 Dimerization subdomain; other site 1382700002096 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 1382700002097 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 1382700002098 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 1382700002099 Trp docking motif [polypeptide binding]; other site 1382700002100 active site 1382700002101 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1382700002102 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1382700002103 dimer interface [polypeptide binding]; other site 1382700002104 motif 1; other site 1382700002105 active site 1382700002106 motif 2; other site 1382700002107 motif 3; other site 1382700002108 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1382700002109 anticodon binding site; other site 1382700002110 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1382700002111 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1382700002112 FeS/SAM binding site; other site 1382700002113 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1382700002114 active site 1382700002115 multimer interface [polypeptide binding]; other site 1382700002116 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1382700002117 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1382700002118 nucleotide binding site [chemical binding]; other site 1382700002119 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1382700002120 SBD interface [polypeptide binding]; other site 1382700002121 co-chaperone HscB; Provisional; Region: hscB; PRK05014 1382700002122 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1382700002123 HSP70 interaction site [polypeptide binding]; other site 1382700002124 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1382700002125 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 1382700002126 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1382700002127 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1382700002128 trimerization site [polypeptide binding]; other site 1382700002129 active site 1382700002130 cysteine desulfurase; Provisional; Region: PRK14012 1382700002131 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1382700002132 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1382700002133 catalytic residue [active] 1382700002134 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 1382700002135 Rrf2 family protein; Region: rrf2_super; TIGR00738 1382700002136 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 1382700002137 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1382700002138 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1382700002139 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1382700002140 active site 1382700002141 dimerization interface [polypeptide binding]; other site 1382700002142 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1382700002143 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 1382700002144 putative NAD(P) binding site [chemical binding]; other site 1382700002145 catalytic Zn binding site [ion binding]; other site 1382700002146 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1382700002147 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1382700002148 dimer interface [polypeptide binding]; other site 1382700002149 active site 1382700002150 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1382700002151 folate binding site [chemical binding]; other site 1382700002152 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 1382700002153 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1382700002154 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1382700002155 Recombination protein O N terminal; Region: RecO_N; pfam11967 1382700002156 Recombination protein O C terminal; Region: RecO_C; pfam02565 1382700002157 GTPase Era; Reviewed; Region: era; PRK00089 1382700002158 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1382700002159 G1 box; other site 1382700002160 GTP/Mg2+ binding site [chemical binding]; other site 1382700002161 Switch I region; other site 1382700002162 G2 box; other site 1382700002163 Switch II region; other site 1382700002164 G3 box; other site 1382700002165 G4 box; other site 1382700002166 G5 box; other site 1382700002167 KH domain; Region: KH_2; pfam07650 1382700002168 signal peptidase I; Provisional; Region: PRK10861 1382700002169 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1382700002170 Catalytic site [active] 1382700002171 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1382700002172 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1382700002173 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1382700002174 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 1382700002175 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1382700002176 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1382700002177 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 1382700002178 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1382700002179 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1382700002180 DNA binding residues [nucleotide binding] 1382700002181 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1382700002182 ligand binding site [chemical binding]; other site 1382700002183 active site 1382700002184 UGI interface [polypeptide binding]; other site 1382700002185 catalytic site [active] 1382700002186 thioredoxin 2; Provisional; Region: PRK10996 1382700002187 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1382700002188 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1382700002189 catalytic residues [active] 1382700002190 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 1382700002191 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 1382700002192 domain interface [polypeptide binding]; other site 1382700002193 putative active site [active] 1382700002194 catalytic site [active] 1382700002195 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 1382700002196 domain interface [polypeptide binding]; other site 1382700002197 putative active site [active] 1382700002198 catalytic site [active] 1382700002199 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1382700002200 IHF dimer interface [polypeptide binding]; other site 1382700002201 IHF - DNA interface [nucleotide binding]; other site 1382700002202 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1382700002203 Active_site [active] 1382700002204 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1382700002205 core dimer interface [polypeptide binding]; other site 1382700002206 peripheral dimer interface [polypeptide binding]; other site 1382700002207 L10 interface [polypeptide binding]; other site 1382700002208 L11 interface [polypeptide binding]; other site 1382700002209 putative EF-Tu interaction site [polypeptide binding]; other site 1382700002210 putative EF-G interaction site [polypeptide binding]; other site 1382700002211 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1382700002212 23S rRNA interface [nucleotide binding]; other site 1382700002213 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1382700002214 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1382700002215 mRNA/rRNA interface [nucleotide binding]; other site 1382700002216 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1382700002217 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1382700002218 23S rRNA interface [nucleotide binding]; other site 1382700002219 L7/L12 interface [polypeptide binding]; other site 1382700002220 putative thiostrepton binding site; other site 1382700002221 L25 interface [polypeptide binding]; other site 1382700002222 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1382700002223 elongation factor Tu; Reviewed; Region: PRK00049 1382700002224 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1382700002225 G1 box; other site 1382700002226 GEF interaction site [polypeptide binding]; other site 1382700002227 GTP/Mg2+ binding site [chemical binding]; other site 1382700002228 Switch I region; other site 1382700002229 G2 box; other site 1382700002230 G3 box; other site 1382700002231 Switch II region; other site 1382700002232 G4 box; other site 1382700002233 G5 box; other site 1382700002234 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1382700002235 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1382700002236 Antibiotic Binding Site [chemical binding]; other site 1382700002237 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1382700002238 FAD binding domain; Region: FAD_binding_4; pfam01565 1382700002239 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1382700002240 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 1382700002241 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 1382700002242 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1382700002243 30S subunit binding site; other site 1382700002244 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 1382700002245 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 1382700002246 Prephenate dehydratase; Region: PDT; pfam00800 1382700002247 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1382700002248 putative L-Phe binding site [chemical binding]; other site 1382700002249 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 1382700002250 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 1382700002251 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1382700002252 prephenate dehydrogenase; Validated; Region: PRK08507 1382700002253 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 1382700002254 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1382700002255 metal binding site [ion binding]; metal-binding site 1382700002256 active site 1382700002257 I-site; other site 1382700002258 putative outer membrane lipoprotein; Provisional; Region: PRK09967 1382700002259 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1382700002260 ligand binding site [chemical binding]; other site 1382700002261 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1382700002262 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1382700002263 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1382700002264 RimM N-terminal domain; Region: RimM; pfam01782 1382700002265 PRC-barrel domain; Region: PRC; pfam05239 1382700002266 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1382700002267 signal recognition particle protein; Provisional; Region: PRK10867 1382700002268 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1382700002269 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1382700002270 P loop; other site 1382700002271 GTP binding site [chemical binding]; other site 1382700002272 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1382700002273 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 1382700002274 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 1382700002275 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1382700002276 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1382700002277 SmpB-tmRNA interface; other site 1382700002278 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 1382700002279 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 1382700002280 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1382700002281 tetramerization interface [polypeptide binding]; other site 1382700002282 NAD(P) binding site [chemical binding]; other site 1382700002283 catalytic residues [active] 1382700002284 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1382700002285 bacterial OsmY and nodulation domain; Region: BON; smart00749 1382700002286 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1382700002287 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 1382700002288 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1382700002289 dimerization interface [polypeptide binding]; other site 1382700002290 putative DNA binding site [nucleotide binding]; other site 1382700002291 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1382700002292 putative Zn2+ binding site [ion binding]; other site 1382700002293 hypothetical protein; Provisional; Region: PRK10556 1382700002294 hypothetical protein; Provisional; Region: PRK10132 1382700002295 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1382700002296 catalytic residues [active] 1382700002297 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 1382700002298 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1382700002299 Walker A/P-loop; other site 1382700002300 ATP binding site [chemical binding]; other site 1382700002301 Q-loop/lid; other site 1382700002302 ABC transporter signature motif; other site 1382700002303 Walker B; other site 1382700002304 D-loop; other site 1382700002305 H-loop/switch region; other site 1382700002306 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1382700002307 transcriptional repressor MprA; Provisional; Region: PRK10870 1382700002308 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1382700002309 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1382700002310 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1382700002311 HlyD family secretion protein; Region: HlyD_3; pfam13437 1382700002312 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1382700002313 glutamate--cysteine ligase; Provisional; Region: PRK02107 1382700002314 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 1382700002315 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1382700002316 motif II; other site 1382700002317 carbon storage regulator; Provisional; Region: PRK01712 1382700002318 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1382700002319 recombinase A; Provisional; Region: recA; PRK09354 1382700002320 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1382700002321 hexamer interface [polypeptide binding]; other site 1382700002322 Walker A motif; other site 1382700002323 ATP binding site [chemical binding]; other site 1382700002324 Walker B motif; other site 1382700002325 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 1382700002326 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 1382700002327 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 1382700002328 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1382700002329 hydrogenase assembly chaperone; Provisional; Region: PRK10409 1382700002330 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 1382700002331 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1382700002332 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1382700002333 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1382700002334 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1382700002335 DNA binding residues [nucleotide binding] 1382700002336 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1382700002337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1382700002338 S-adenosylmethionine binding site [chemical binding]; other site 1382700002339 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1382700002340 substrate binding site; other site 1382700002341 dimer interface; other site 1382700002342 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 1382700002343 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1382700002344 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1382700002345 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1382700002346 enolase; Provisional; Region: eno; PRK00077 1382700002347 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1382700002348 dimer interface [polypeptide binding]; other site 1382700002349 metal binding site [ion binding]; metal-binding site 1382700002350 substrate binding pocket [chemical binding]; other site 1382700002351 CTP synthetase; Validated; Region: pyrG; PRK05380 1382700002352 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1382700002353 Catalytic site [active] 1382700002354 active site 1382700002355 UTP binding site [chemical binding]; other site 1382700002356 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1382700002357 active site 1382700002358 putative oxyanion hole; other site 1382700002359 catalytic triad [active] 1382700002360 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1382700002361 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1382700002362 homodimer interface [polypeptide binding]; other site 1382700002363 metal binding site [ion binding]; metal-binding site 1382700002364 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1382700002365 homodimer interface [polypeptide binding]; other site 1382700002366 active site 1382700002367 putative chemical substrate binding site [chemical binding]; other site 1382700002368 metal binding site [ion binding]; metal-binding site 1382700002369 antitoxin MazE; Provisional; Region: PRK09798 1382700002370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1382700002371 D-galactonate transporter; Region: 2A0114; TIGR00893 1382700002372 putative substrate translocation pore; other site 1382700002373 SecY interacting protein Syd; Provisional; Region: PRK04968 1382700002374 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1382700002375 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1382700002376 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1382700002377 serine transporter; Region: stp; TIGR00814 1382700002378 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1382700002379 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1382700002380 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1382700002381 flap endonuclease-like protein; Provisional; Region: PRK09482 1382700002382 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1382700002383 active site 1382700002384 metal binding site 1 [ion binding]; metal-binding site 1382700002385 putative 5' ssDNA interaction site; other site 1382700002386 metal binding site 3; metal-binding site 1382700002387 metal binding site 2 [ion binding]; metal-binding site 1382700002388 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1382700002389 putative DNA binding site [nucleotide binding]; other site 1382700002390 putative metal binding site [ion binding]; other site 1382700002391 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1382700002392 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1382700002393 intersubunit interface [polypeptide binding]; other site 1382700002394 active site 1382700002395 Zn2+ binding site [ion binding]; other site 1382700002396 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 1382700002397 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1382700002398 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1382700002399 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1382700002400 dimerization interface [polypeptide binding]; other site 1382700002401 substrate binding pocket [chemical binding]; other site 1382700002402 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1382700002403 CsdA-binding activator; Provisional; Region: PRK15019 1382700002404 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 1382700002405 AMIN domain; Region: AMIN; pfam11741 1382700002406 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1382700002407 active site 1382700002408 metal binding site [ion binding]; metal-binding site 1382700002409 N-acetylglutamate synthase; Validated; Region: PRK05279 1382700002410 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1382700002411 putative feedback inhibition sensing region; other site 1382700002412 putative nucleotide binding site [chemical binding]; other site 1382700002413 putative substrate binding site [chemical binding]; other site 1382700002414 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1382700002415 Coenzyme A binding pocket [chemical binding]; other site 1382700002416 hypothetical protein; Provisional; Region: PRK10332 1382700002417 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 1382700002418 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1382700002419 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1382700002420 dimerization interface [polypeptide binding]; other site 1382700002421 active site 1382700002422 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 1382700002423 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1382700002424 putative active site [active] 1382700002425 Ap4A binding site [chemical binding]; other site 1382700002426 nudix motif; other site 1382700002427 putative metal binding site [ion binding]; other site 1382700002428 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1382700002429 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1382700002430 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1382700002431 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1382700002432 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1382700002433 dimerization interface [polypeptide binding]; other site 1382700002434 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1382700002435 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1382700002436 serine transporter; Region: stp; TIGR00814 1382700002437 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1382700002438 Peptidase family M23; Region: Peptidase_M23; pfam01551 1382700002439 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1382700002440 carbamate kinase; Reviewed; Region: PRK12686 1382700002441 putative substrate binding site [chemical binding]; other site 1382700002442 homodimer interface [polypeptide binding]; other site 1382700002443 nucleotide binding site [chemical binding]; other site 1382700002444 nucleotide binding site [chemical binding]; other site 1382700002445 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1382700002446 Ligand binding site; other site 1382700002447 metal-binding site 1382700002448 peptide chain release factor 2; Provisional; Region: PRK08787 1382700002449 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1382700002450 RF-1 domain; Region: RF-1; pfam00472 1382700002451 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1382700002452 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1382700002453 dimerization domain [polypeptide binding]; other site 1382700002454 dimer interface [polypeptide binding]; other site 1382700002455 catalytic residues [active] 1382700002456 flavodoxin FldB; Provisional; Region: PRK12359 1382700002457 hypothetical protein; Provisional; Region: PRK10878 1382700002458 hemolysin; Provisional; Region: PRK15087 1382700002459 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1382700002460 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 1382700002461 hypothetical protein; Reviewed; Region: PRK01736 1382700002462 Z-ring-associated protein; Provisional; Region: PRK10972 1382700002463 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1382700002464 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1382700002465 ligand binding site [chemical binding]; other site 1382700002466 NAD binding site [chemical binding]; other site 1382700002467 tetramer interface [polypeptide binding]; other site 1382700002468 catalytic site [active] 1382700002469 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1382700002470 L-serine binding site [chemical binding]; other site 1382700002471 ACT domain interface; other site 1382700002472 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1382700002473 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1382700002474 active site 1382700002475 dimer interface [polypeptide binding]; other site 1382700002476 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1382700002477 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1382700002478 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 1382700002479 putative dimerization interface [polypeptide binding]; other site 1382700002480 mechanosensitive channel MscS; Provisional; Region: PRK10334 1382700002481 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1382700002482 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1382700002483 Phosphoglycerate kinase; Region: PGK; pfam00162 1382700002484 substrate binding site [chemical binding]; other site 1382700002485 hinge regions; other site 1382700002486 ADP binding site [chemical binding]; other site 1382700002487 catalytic site [active] 1382700002488 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1382700002489 agmatinase; Region: agmatinase; TIGR01230 1382700002490 oligomer interface [polypeptide binding]; other site 1382700002491 putative active site [active] 1382700002492 Mn binding site [ion binding]; other site 1382700002493 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 1382700002494 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1382700002495 dimer interface [polypeptide binding]; other site 1382700002496 active site 1382700002497 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1382700002498 catalytic residues [active] 1382700002499 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1382700002500 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1382700002501 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1382700002502 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1382700002503 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1382700002504 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1382700002505 RNA methyltransferase, RsmE family; Region: TIGR00046 1382700002506 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1382700002507 YGGT family; Region: YGGT; pfam02325 1382700002508 YGGT family; Region: YGGT; pfam02325 1382700002509 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 1382700002510 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 1382700002511 homodimer interface [polypeptide binding]; other site 1382700002512 active site 1382700002513 hypothetical protein; Provisional; Region: PRK10626 1382700002514 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 1382700002515 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1382700002516 oxidative damage protection protein; Provisional; Region: PRK05408 1382700002517 murein transglycosylase C; Provisional; Region: mltC; PRK11671 1382700002518 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 1382700002519 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1382700002520 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1382700002521 catalytic residue [active] 1382700002522 Alpha-2,8-polysialyltransferase (POLYST); Region: A-2_8-polyST; pfam07388 1382700002523 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1382700002524 hypothetical protein; Provisional; Region: PRK09732 1382700002525 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1382700002526 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1382700002527 TMP-binding site; other site 1382700002528 ATP-binding site [chemical binding]; other site 1382700002529 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 1382700002530 hydrogenase 2 large subunit; Provisional; Region: PRK10467 1382700002531 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1382700002532 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 1382700002533 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1382700002534 hydrogenase 2 small subunit; Provisional; Region: PRK10468 1382700002535 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1382700002536 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1382700002537 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 1382700002538 hypothetical protein; Provisional; Region: PRK05208 1382700002539 biopolymer transport protein ExbD; Provisional; Region: PRK11267 1382700002540 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1382700002541 biopolymer transport protein ExbB; Provisional; Region: PRK10414 1382700002542 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1382700002543 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1382700002544 putative outer membrane lipoprotein; Provisional; Region: PRK09973 1382700002545 FtsI repressor; Provisional; Region: PRK10883 1382700002546 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1382700002547 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1382700002548 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 1382700002549 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1382700002550 putative acyl-acceptor binding pocket; other site 1382700002551 TIGR00156 family protein; Region: TIGR00156 1382700002552 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1382700002553 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1382700002554 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1382700002555 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1382700002556 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1382700002557 N-terminal plug; other site 1382700002558 ligand-binding site [chemical binding]; other site 1382700002559 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 1382700002560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1382700002561 ATP binding site [chemical binding]; other site 1382700002562 Mg2+ binding site [ion binding]; other site 1382700002563 G-X-G motif; other site 1382700002564 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1382700002565 anchoring element; other site 1382700002566 dimer interface [polypeptide binding]; other site 1382700002567 ATP binding site [chemical binding]; other site 1382700002568 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1382700002569 active site 1382700002570 metal binding site [ion binding]; metal-binding site 1382700002571 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1382700002572 esterase YqiA; Provisional; Region: PRK11071 1382700002573 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1382700002574 putative dehydrogenase; Provisional; Region: PRK11039 1382700002575 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1382700002576 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1382700002577 dimer interface [polypeptide binding]; other site 1382700002578 ADP-ribose binding site [chemical binding]; other site 1382700002579 active site 1382700002580 nudix motif; other site 1382700002581 metal binding site [ion binding]; metal-binding site 1382700002582 hypothetical protein; Provisional; Region: PRK11653 1382700002583 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1382700002584 putative disulfide oxidoreductase; Provisional; Region: PRK04307 1382700002585 zinc transporter ZupT; Provisional; Region: PRK04201 1382700002586 ZIP Zinc transporter; Region: Zip; pfam02535 1382700002587 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 1382700002588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1382700002589 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1382700002590 SH3 domain-containing protein; Provisional; Region: PRK10884 1382700002591 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1382700002592 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1382700002593 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1382700002594 homooctamer interface [polypeptide binding]; other site 1382700002595 active site 1382700002596 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1382700002597 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 1382700002598 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1382700002599 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1382700002600 transmembrane helices; other site 1382700002601 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1382700002602 DNA primase; Validated; Region: dnaG; PRK05667 1382700002603 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1382700002604 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1382700002605 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1382700002606 active site 1382700002607 metal binding site [ion binding]; metal-binding site 1382700002608 interdomain interaction site; other site 1382700002609 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1382700002610 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1382700002611 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1382700002612 active site 1382700002613 SUMO-1 interface [polypeptide binding]; other site 1382700002614 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 1382700002615 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1382700002616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1382700002617 S-adenosylmethionine binding site [chemical binding]; other site 1382700002618 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1382700002619 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1382700002620 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 1382700002621 Glucuronate isomerase; Region: UxaC; pfam02614 1382700002622 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1382700002623 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1382700002624 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1382700002625 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1382700002626 YqjK-like protein; Region: YqjK; pfam13997 1382700002627 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1382700002628 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1382700002629 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1382700002630 dimerization interface [polypeptide binding]; other site 1382700002631 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1382700002632 homotrimer interaction site [polypeptide binding]; other site 1382700002633 putative active site [active] 1382700002634 threonine/serine transporter TdcC; Provisional; Region: PRK13629 1382700002635 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1382700002636 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1382700002637 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1382700002638 tetramer interface [polypeptide binding]; other site 1382700002639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1382700002640 catalytic residue [active] 1382700002641 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 1382700002642 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1382700002643 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1382700002644 active pocket/dimerization site; other site 1382700002645 active site 1382700002646 phosphorylation site [posttranslational modification] 1382700002647 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453 1382700002648 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1382700002649 active site 1382700002650 intersubunit interface [polypeptide binding]; other site 1382700002651 zinc binding site [ion binding]; other site 1382700002652 Na+ binding site [ion binding]; other site 1382700002653 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1382700002654 active site 1382700002655 phosphorylation site [posttranslational modification] 1382700002656 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 1382700002657 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1382700002658 dimer interface [polypeptide binding]; other site 1382700002659 active site 1382700002660 outer membrane lipoprotein; Provisional; Region: PRK11023 1382700002661 BON domain; Region: BON; pfam04972 1382700002662 BON domain; Region: BON; pfam04972 1382700002663 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1382700002664 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1382700002665 Coenzyme A binding pocket [chemical binding]; other site 1382700002666 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 1382700002667 lipoprotein NlpI; Provisional; Region: PRK11189 1382700002668 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1382700002669 binding surface 1382700002670 TPR motif; other site 1382700002671 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1382700002672 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1382700002673 RNA binding site [nucleotide binding]; other site 1382700002674 active site 1382700002675 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1382700002676 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1382700002677 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1382700002678 NusA N-terminal domain; Region: NusA_N; pfam08529 1382700002679 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1382700002680 RNA binding site [nucleotide binding]; other site 1382700002681 homodimer interface [polypeptide binding]; other site 1382700002682 NusA-like KH domain; Region: KH_5; pfam13184 1382700002683 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1382700002684 G-X-X-G motif; other site 1382700002685 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1382700002686 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1382700002687 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1382700002688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1382700002689 S-adenosylmethionine binding site [chemical binding]; other site 1382700002690 RNA-binding protein YhbY; Provisional; Region: PRK10343 1382700002691 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1382700002692 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1382700002693 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1382700002694 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1382700002695 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1382700002696 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1382700002697 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1382700002698 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1382700002699 hinge; other site 1382700002700 active site 1382700002701 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1382700002702 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1382700002703 conserved hypothetical integral membrane protein; Region: TIGR00056 1382700002704 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 1382700002705 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1382700002706 Walker A/P-loop; other site 1382700002707 ATP binding site [chemical binding]; other site 1382700002708 Q-loop/lid; other site 1382700002709 ABC transporter signature motif; other site 1382700002710 Walker B; other site 1382700002711 D-loop; other site 1382700002712 H-loop/switch region; other site 1382700002713 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1382700002714 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1382700002715 putative active site [active] 1382700002716 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1382700002717 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 1382700002718 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1382700002719 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 1382700002720 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1382700002721 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 1382700002722 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1382700002723 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 1382700002724 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1382700002725 Walker A/P-loop; other site 1382700002726 ATP binding site [chemical binding]; other site 1382700002727 Q-loop/lid; other site 1382700002728 ABC transporter signature motif; other site 1382700002729 Walker B; other site 1382700002730 D-loop; other site 1382700002731 H-loop/switch region; other site 1382700002732 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1382700002733 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1382700002734 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1382700002735 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1382700002736 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1382700002737 30S subunit binding site; other site 1382700002738 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1382700002739 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1382700002740 dimerization domain swap beta strand [polypeptide binding]; other site 1382700002741 regulatory protein interface [polypeptide binding]; other site 1382700002742 active site 1382700002743 regulatory phosphorylation site [posttranslational modification]; other site 1382700002744 Domain of unknown function (DUF386); Region: DUF386; cl01047 1382700002745 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 1382700002746 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1382700002747 putative active site cavity [active] 1382700002748 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 1382700002749 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1382700002750 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1382700002751 C-terminal domain interface [polypeptide binding]; other site 1382700002752 putative GSH binding site (G-site) [chemical binding]; other site 1382700002753 dimer interface [polypeptide binding]; other site 1382700002754 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1382700002755 dimer interface [polypeptide binding]; other site 1382700002756 N-terminal domain interface [polypeptide binding]; other site 1382700002757 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1382700002758 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1382700002759 23S rRNA interface [nucleotide binding]; other site 1382700002760 L3 interface [polypeptide binding]; other site 1382700002761 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 1382700002762 hypothetical protein; Provisional; Region: PRK11677 1382700002763 serine endoprotease; Provisional; Region: PRK10898 1382700002764 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1382700002765 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1382700002766 arginine repressor; Provisional; Region: PRK05066 1382700002767 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1382700002768 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1382700002769 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1382700002770 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1382700002771 RNAase interaction site [polypeptide binding]; other site 1382700002772 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1382700002773 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1382700002774 HlyD family secretion protein; Region: HlyD_3; pfam13437 1382700002775 transcriptional regulator; Provisional; Region: PRK10632 1382700002776 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1382700002777 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1382700002778 putative effector binding pocket; other site 1382700002779 dimerization interface [polypeptide binding]; other site 1382700002780 protease TldD; Provisional; Region: tldD; PRK10735 1382700002781 ribonuclease G; Provisional; Region: PRK11712 1382700002782 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1382700002783 homodimer interface [polypeptide binding]; other site 1382700002784 oligonucleotide binding site [chemical binding]; other site 1382700002785 rod shape-determining protein MreD; Provisional; Region: PRK11060 1382700002786 rod shape-determining protein MreC; Region: mreC; TIGR00219 1382700002787 rod shape-determining protein MreC; Region: MreC; pfam04085 1382700002788 rod shape-determining protein MreB; Provisional; Region: PRK13927 1382700002789 MreB and similar proteins; Region: MreB_like; cd10225 1382700002790 nucleotide binding site [chemical binding]; other site 1382700002791 Mg binding site [ion binding]; other site 1382700002792 putative protofilament interaction site [polypeptide binding]; other site 1382700002793 RodZ interaction site [polypeptide binding]; other site 1382700002794 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1382700002795 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1382700002796 carboxyltransferase (CT) interaction site; other site 1382700002797 biotinylation site [posttranslational modification]; other site 1382700002798 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1382700002799 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1382700002800 substrate binding site [chemical binding]; other site 1382700002801 ATP binding site [chemical binding]; other site 1382700002802 hypothetical protein; Provisional; Region: PRK10633 1382700002803 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1382700002804 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1382700002805 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1382700002806 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1382700002807 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 1382700002808 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1382700002809 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1382700002810 trimer interface [polypeptide binding]; other site 1382700002811 putative metal binding site [ion binding]; other site 1382700002812 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1382700002813 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1382700002814 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1382700002815 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1382700002816 hypothetical protein; Provisional; Region: PRK10736 1382700002817 DNA protecting protein DprA; Region: dprA; TIGR00732 1382700002818 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1382700002819 active site 1382700002820 catalytic residues [active] 1382700002821 metal binding site [ion binding]; metal-binding site 1382700002822 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1382700002823 TrkA-N domain; Region: TrkA_N; pfam02254 1382700002824 TrkA-C domain; Region: TrkA_C; pfam02080 1382700002825 TrkA-N domain; Region: TrkA_N; pfam02254 1382700002826 TrkA-C domain; Region: TrkA_C; pfam02080 1382700002827 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1382700002828 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1382700002829 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1382700002830 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1382700002831 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1382700002832 alphaNTD homodimer interface [polypeptide binding]; other site 1382700002833 alphaNTD - beta interaction site [polypeptide binding]; other site 1382700002834 alphaNTD - beta' interaction site [polypeptide binding]; other site 1382700002835 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1382700002836 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1382700002837 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1382700002838 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1382700002839 RNA binding surface [nucleotide binding]; other site 1382700002840 30S ribosomal protein S11; Validated; Region: PRK05309 1382700002841 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1382700002842 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1382700002843 SecY translocase; Region: SecY; pfam00344 1382700002844 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1382700002845 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1382700002846 23S rRNA binding site [nucleotide binding]; other site 1382700002847 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1382700002848 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1382700002849 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1382700002850 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1382700002851 23S rRNA interface [nucleotide binding]; other site 1382700002852 5S rRNA interface [nucleotide binding]; other site 1382700002853 L27 interface [polypeptide binding]; other site 1382700002854 L5 interface [polypeptide binding]; other site 1382700002855 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1382700002856 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1382700002857 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1382700002858 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1382700002859 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1382700002860 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1382700002861 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1382700002862 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1382700002863 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1382700002864 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1382700002865 RNA binding site [nucleotide binding]; other site 1382700002866 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1382700002867 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1382700002868 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1382700002869 23S rRNA interface [nucleotide binding]; other site 1382700002870 putative translocon interaction site; other site 1382700002871 signal recognition particle (SRP54) interaction site; other site 1382700002872 L23 interface [polypeptide binding]; other site 1382700002873 trigger factor interaction site; other site 1382700002874 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1382700002875 23S rRNA interface [nucleotide binding]; other site 1382700002876 5S rRNA interface [nucleotide binding]; other site 1382700002877 putative antibiotic binding site [chemical binding]; other site 1382700002878 L25 interface [polypeptide binding]; other site 1382700002879 L27 interface [polypeptide binding]; other site 1382700002880 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1382700002881 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1382700002882 G-X-X-G motif; other site 1382700002883 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1382700002884 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1382700002885 protein-rRNA interface [nucleotide binding]; other site 1382700002886 putative translocon binding site; other site 1382700002887 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1382700002888 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1382700002889 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1382700002890 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1382700002891 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1382700002892 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1382700002893 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 1382700002894 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1382700002895 Type II secretory pathway, component PulC [Intracellular trafficking and secretion]; Region: PulC; COG3031 1382700002896 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1382700002897 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1382700002898 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1382700002899 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1382700002900 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1382700002901 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1382700002902 heme binding site [chemical binding]; other site 1382700002903 ferroxidase pore; other site 1382700002904 ferroxidase diiron center [ion binding]; other site 1382700002905 elongation factor Tu; Reviewed; Region: PRK00049 1382700002906 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1382700002907 G1 box; other site 1382700002908 GEF interaction site [polypeptide binding]; other site 1382700002909 GTP/Mg2+ binding site [chemical binding]; other site 1382700002910 Switch I region; other site 1382700002911 G2 box; other site 1382700002912 G3 box; other site 1382700002913 Switch II region; other site 1382700002914 G4 box; other site 1382700002915 G5 box; other site 1382700002916 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1382700002917 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1382700002918 Antibiotic Binding Site [chemical binding]; other site 1382700002919 elongation factor G; Reviewed; Region: PRK00007 1382700002920 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1382700002921 G1 box; other site 1382700002922 putative GEF interaction site [polypeptide binding]; other site 1382700002923 GTP/Mg2+ binding site [chemical binding]; other site 1382700002924 Switch I region; other site 1382700002925 G2 box; other site 1382700002926 G3 box; other site 1382700002927 Switch II region; other site 1382700002928 G4 box; other site 1382700002929 G5 box; other site 1382700002930 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1382700002931 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1382700002932 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1382700002933 30S ribosomal protein S7; Validated; Region: PRK05302 1382700002934 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1382700002935 S17 interaction site [polypeptide binding]; other site 1382700002936 S8 interaction site; other site 1382700002937 16S rRNA interaction site [nucleotide binding]; other site 1382700002938 streptomycin interaction site [chemical binding]; other site 1382700002939 23S rRNA interaction site [nucleotide binding]; other site 1382700002940 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1382700002941 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 1382700002942 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1382700002943 YheO-like PAS domain; Region: PAS_6; pfam08348 1382700002944 HTH domain; Region: HTH_22; pfam13309 1382700002945 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 1382700002946 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1382700002947 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1382700002948 phi X174 lysis protein; Provisional; Region: PRK02793 1382700002949 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1382700002950 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1382700002951 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 1382700002952 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 1382700002953 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1382700002954 TrkA-N domain; Region: TrkA_N; pfam02254 1382700002955 hypothetical protein; Provisional; Region: PRK10738 1382700002956 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1382700002957 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1382700002958 ligand binding site [chemical binding]; other site 1382700002959 flexible hinge region; other site 1382700002960 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1382700002961 putative switch regulator; other site 1382700002962 non-specific DNA interactions [nucleotide binding]; other site 1382700002963 DNA binding site [nucleotide binding] 1382700002964 sequence specific DNA binding site [nucleotide binding]; other site 1382700002965 putative cAMP binding site [chemical binding]; other site 1382700002966 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1382700002967 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1382700002968 substrate binding site [chemical binding]; other site 1382700002969 putative transporter; Provisional; Region: PRK03699 1382700002970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1382700002971 putative substrate translocation pore; other site 1382700002972 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1382700002973 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1382700002974 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1382700002975 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1382700002976 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1382700002977 nitrite transporter NirC; Provisional; Region: PRK11562 1382700002978 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 1382700002979 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1382700002980 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1382700002981 active site 1382700002982 HIGH motif; other site 1382700002983 dimer interface [polypeptide binding]; other site 1382700002984 KMSKS motif; other site 1382700002985 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1382700002986 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1382700002987 substrate binding site [chemical binding]; other site 1382700002988 hexamer interface [polypeptide binding]; other site 1382700002989 metal binding site [ion binding]; metal-binding site 1382700002990 shikimate kinase; Reviewed; Region: aroK; PRK00131 1382700002991 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1382700002992 ADP binding site [chemical binding]; other site 1382700002993 magnesium binding site [ion binding]; other site 1382700002994 putative shikimate binding site; other site 1382700002995 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1382700002996 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1382700002997 motif II; other site 1382700002998 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1382700002999 RNA binding surface [nucleotide binding]; other site 1382700003000 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1382700003001 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1382700003002 dimerization interface [polypeptide binding]; other site 1382700003003 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1382700003004 dimer interface [polypeptide binding]; other site 1382700003005 phosphorylation site [posttranslational modification] 1382700003006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1382700003007 ATP binding site [chemical binding]; other site 1382700003008 G-X-G motif; other site 1382700003009 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1382700003010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1382700003011 active site 1382700003012 phosphorylation site [posttranslational modification] 1382700003013 intermolecular recognition site; other site 1382700003014 dimerization interface [polypeptide binding]; other site 1382700003015 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1382700003016 DNA binding site [nucleotide binding] 1382700003017 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1382700003018 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1382700003019 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1382700003020 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 1382700003021 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1382700003022 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1382700003023 high-affinity gluconate transporter; Provisional; Region: PRK14984 1382700003024 gluconate transporter; Region: gntP; TIGR00791 1382700003025 intramembrane serine protease GlpG; Provisional; Region: PRK10907 1382700003026 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 1382700003027 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1382700003028 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1382700003029 glycogen phosphorylase; Provisional; Region: PRK14986 1382700003030 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1382700003031 homodimer interface [polypeptide binding]; other site 1382700003032 active site pocket [active] 1382700003033 glycogen synthase; Provisional; Region: glgA; PRK00654 1382700003034 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1382700003035 ADP-binding pocket [chemical binding]; other site 1382700003036 homodimer interface [polypeptide binding]; other site 1382700003037 putative antibiotic transporter; Provisional; Region: PRK10739 1382700003038 Pirin-related protein [General function prediction only]; Region: COG1741 1382700003039 Pirin; Region: Pirin; pfam02678 1382700003040 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1382700003041 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1382700003042 Walker A/P-loop; other site 1382700003043 ATP binding site [chemical binding]; other site 1382700003044 Q-loop/lid; other site 1382700003045 ABC transporter signature motif; other site 1382700003046 Walker B; other site 1382700003047 D-loop; other site 1382700003048 H-loop/switch region; other site 1382700003049 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1382700003050 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1382700003051 dimerization interface [polypeptide binding]; other site 1382700003052 ligand binding site [chemical binding]; other site 1382700003053 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1382700003054 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1382700003055 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1382700003056 DNA binding residues [nucleotide binding] 1382700003057 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1382700003058 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 1382700003059 cell division protein FtsE; Provisional; Region: PRK10908 1382700003060 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1382700003061 Walker A/P-loop; other site 1382700003062 ATP binding site [chemical binding]; other site 1382700003063 Q-loop/lid; other site 1382700003064 ABC transporter signature motif; other site 1382700003065 Walker B; other site 1382700003066 D-loop; other site 1382700003067 H-loop/switch region; other site 1382700003068 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1382700003069 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1382700003070 S-adenosylmethionine binding site [chemical binding]; other site 1382700003071 hypothetical protein; Provisional; Region: PRK10910 1382700003072 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 1382700003073 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1382700003074 CPxP motif; other site 1382700003075 hypothetical protein; Provisional; Region: PRK11212 1382700003076 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 1382700003077 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1382700003078 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 1382700003079 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1382700003080 Walker A/P-loop; other site 1382700003081 ATP binding site [chemical binding]; other site 1382700003082 Q-loop/lid; other site 1382700003083 ABC transporter signature motif; other site 1382700003084 Walker B; other site 1382700003085 D-loop; other site 1382700003086 H-loop/switch region; other site 1382700003087 nickel responsive regulator; Provisional; Region: PRK02967 1382700003088 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 1382700003089 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1382700003090 dimerization domain swap beta strand [polypeptide binding]; other site 1382700003091 regulatory protein interface [polypeptide binding]; other site 1382700003092 active site 1382700003093 regulatory phosphorylation site [posttranslational modification]; other site 1382700003094 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1382700003095 intersubunit interface [polypeptide binding]; other site 1382700003096 active site 1382700003097 zinc binding site [ion binding]; other site 1382700003098 Na+ binding site [ion binding]; other site 1382700003099 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1382700003100 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1382700003101 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1382700003102 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1382700003103 universal stress protein UspB; Provisional; Region: PRK04960 1382700003104 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1382700003105 Ligand Binding Site [chemical binding]; other site 1382700003106 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1382700003107 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1382700003108 ArsC family; Region: ArsC; pfam03960 1382700003109 catalytic residues [active] 1382700003110 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 1382700003111 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1382700003112 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1382700003113 DNA binding residues [nucleotide binding] 1382700003114 dimerization interface [polypeptide binding]; other site 1382700003115 acid-resistance protein; Provisional; Region: hdeB; PRK11566 1382700003116 acid-resistance membrane protein; Provisional; Region: PRK10209 1382700003117 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1382700003118 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1382700003119 pyruvate kinase; Provisional; Region: PRK05826 1382700003120 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 1382700003121 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1382700003122 HlyD family secretion protein; Region: HlyD_3; pfam13437 1382700003123 transcriptional regulator YdeO; Provisional; Region: PRK09940 1382700003124 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1382700003125 inner membrane protein YhjD; Region: TIGR00766 1382700003126 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1382700003127 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1382700003128 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 1382700003129 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 1382700003130 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1382700003131 dipeptide transporter; Provisional; Region: PRK10913 1382700003132 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1382700003133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1382700003134 dimer interface [polypeptide binding]; other site 1382700003135 conserved gate region; other site 1382700003136 putative PBP binding loops; other site 1382700003137 ABC-ATPase subunit interface; other site 1382700003138 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1382700003139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1382700003140 dimer interface [polypeptide binding]; other site 1382700003141 conserved gate region; other site 1382700003142 putative PBP binding loops; other site 1382700003143 ABC-ATPase subunit interface; other site 1382700003144 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1382700003145 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1382700003146 dimerization interface [polypeptide binding]; other site 1382700003147 ligand binding site [chemical binding]; other site 1382700003148 NADP binding site [chemical binding]; other site 1382700003149 catalytic site [active] 1382700003150 Predicted transcriptional regulator [Transcription]; Region: COG2944 1382700003151 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1382700003152 non-specific DNA binding site [nucleotide binding]; other site 1382700003153 salt bridge; other site 1382700003154 sequence-specific DNA binding site [nucleotide binding]; other site 1382700003155 xylose isomerase; Provisional; Region: PRK05474 1382700003156 xylose isomerase; Region: xylose_isom_A; TIGR02630 1382700003157 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 1382700003158 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1382700003159 putative ligand binding site [chemical binding]; other site 1382700003160 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1382700003161 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1382700003162 TM-ABC transporter signature motif; other site 1382700003163 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 1382700003164 putative dimerization interface [polypeptide binding]; other site 1382700003165 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1382700003166 putative ligand binding site [chemical binding]; other site 1382700003167 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1382700003168 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1382700003169 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1382700003170 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1382700003171 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1382700003172 Bacterial transcriptional regulator; Region: IclR; pfam01614 1382700003173 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 1382700003174 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1382700003175 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 1382700003176 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1382700003177 active site 1382700003178 dimer interface [polypeptide binding]; other site 1382700003179 magnesium binding site [ion binding]; other site 1382700003180 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1382700003181 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1382700003182 NAD(P) binding site [chemical binding]; other site 1382700003183 catalytic residues [active] 1382700003184 selenocysteine synthase; Provisional; Region: PRK04311 1382700003185 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1382700003186 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1382700003187 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1382700003188 catalytic residue [active] 1382700003189 putative glutathione S-transferase; Provisional; Region: PRK10357 1382700003190 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1382700003191 putative C-terminal domain interface [polypeptide binding]; other site 1382700003192 putative GSH binding site (G-site) [chemical binding]; other site 1382700003193 putative dimer interface [polypeptide binding]; other site 1382700003194 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1382700003195 dimer interface [polypeptide binding]; other site 1382700003196 N-terminal domain interface [polypeptide binding]; other site 1382700003197 putative substrate binding pocket (H-site) [chemical binding]; other site 1382700003198 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1382700003199 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1382700003200 HlyD family secretion protein; Region: HlyD_3; pfam13437 1382700003201 hypothetical protein; Provisional; Region: PRK11020 1382700003202 L-lactate permease; Provisional; Region: PRK10420 1382700003203 glycolate transporter; Provisional; Region: PRK09695 1382700003204 putative rRNA methylase; Provisional; Region: PRK10358 1382700003205 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1382700003206 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 1382700003207 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1382700003208 trimer interface [polypeptide binding]; other site 1382700003209 active site 1382700003210 substrate binding site [chemical binding]; other site 1382700003211 CoA binding site [chemical binding]; other site 1382700003212 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1382700003213 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1382700003214 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1382700003215 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1382700003216 GSH binding site [chemical binding]; other site 1382700003217 catalytic residues [active] 1382700003218 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1382700003219 active site residue [active] 1382700003220 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1382700003221 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1382700003222 NAD(P) binding site [chemical binding]; other site 1382700003223 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1382700003224 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 1382700003225 NADP binding site [chemical binding]; other site 1382700003226 homopentamer interface [polypeptide binding]; other site 1382700003227 substrate binding site [chemical binding]; other site 1382700003228 active site 1382700003229 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1382700003230 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1382700003231 putative active site [active] 1382700003232 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1382700003233 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1382700003234 putative active site [active] 1382700003235 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1382700003236 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1382700003237 active site 1382700003238 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 1382700003239 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1382700003240 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1382700003241 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1382700003242 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1382700003243 DNA binding site [nucleotide binding] 1382700003244 catalytic residue [active] 1382700003245 H2TH interface [polypeptide binding]; other site 1382700003246 putative catalytic residues [active] 1382700003247 turnover-facilitating residue; other site 1382700003248 intercalation triad [nucleotide binding]; other site 1382700003249 8OG recognition residue [nucleotide binding]; other site 1382700003250 putative reading head residues; other site 1382700003251 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1382700003252 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1382700003253 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1382700003254 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1382700003255 hypothetical protein; Reviewed; Region: PRK00024 1382700003256 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1382700003257 MPN+ (JAMM) motif; other site 1382700003258 Zinc-binding site [ion binding]; other site 1382700003259 ribonuclease PH; Reviewed; Region: rph; PRK00173 1382700003260 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1382700003261 hexamer interface [polypeptide binding]; other site 1382700003262 active site 1382700003263 Predicted membrane protein [Function unknown]; Region: COG2860 1382700003264 UPF0126 domain; Region: UPF0126; pfam03458 1382700003265 UPF0126 domain; Region: UPF0126; pfam03458 1382700003266 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1382700003267 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1382700003268 catalytic site [active] 1382700003269 G-X2-G-X-G-K; other site 1382700003270 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1382700003271 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1382700003272 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1382700003273 Zn2+ binding site [ion binding]; other site 1382700003274 Mg2+ binding site [ion binding]; other site 1382700003275 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1382700003276 synthetase active site [active] 1382700003277 NTP binding site [chemical binding]; other site 1382700003278 metal binding site [ion binding]; metal-binding site 1382700003279 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1382700003280 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1382700003281 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 1382700003282 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1382700003283 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 1382700003284 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1382700003285 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1382700003286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1382700003287 putative substrate translocation pore; other site 1382700003288 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1382700003289 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1382700003290 putative valine binding site [chemical binding]; other site 1382700003291 dimer interface [polypeptide binding]; other site 1382700003292 Predicted membrane protein [Function unknown]; Region: COG2149 1382700003293 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1382700003294 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1382700003295 putative dimer interface [polypeptide binding]; other site 1382700003296 sugar phosphate phosphatase; Provisional; Region: PRK10513 1382700003297 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1382700003298 active site 1382700003299 motif I; other site 1382700003300 motif II; other site 1382700003301 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1382700003302 recF protein; Region: recf; TIGR00611 1382700003303 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1382700003304 Walker A/P-loop; other site 1382700003305 ATP binding site [chemical binding]; other site 1382700003306 Q-loop/lid; other site 1382700003307 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1382700003308 ABC transporter signature motif; other site 1382700003309 Walker B; other site 1382700003310 D-loop; other site 1382700003311 H-loop/switch region; other site 1382700003312 DNA polymerase III subunit beta; Validated; Region: PRK05643 1382700003313 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1382700003314 putative DNA binding surface [nucleotide binding]; other site 1382700003315 dimer interface [polypeptide binding]; other site 1382700003316 beta-clamp/clamp loader binding surface; other site 1382700003317 beta-clamp/translesion DNA polymerase binding surface; other site 1382700003318 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1382700003319 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1382700003320 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1382700003321 Walker A motif; other site 1382700003322 ATP binding site [chemical binding]; other site 1382700003323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1382700003324 Walker B motif; other site 1382700003325 arginine finger; other site 1382700003326 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1382700003327 DnaA box-binding interface [nucleotide binding]; other site 1382700003328 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1382700003329 membrane protein insertase; Provisional; Region: PRK01318 1382700003330 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1382700003331 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 1382700003332 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1382700003333 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1382700003334 catalytic residue [active] 1382700003335 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1382700003336 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 1382700003337 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1382700003338 active site 1382700003339 motif I; other site 1382700003340 motif II; other site 1382700003341 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 1382700003342 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1382700003343 Walker A/P-loop; other site 1382700003344 ATP binding site [chemical binding]; other site 1382700003345 Q-loop/lid; other site 1382700003346 ABC transporter signature motif; other site 1382700003347 Walker B; other site 1382700003348 D-loop; other site 1382700003349 H-loop/switch region; other site 1382700003350 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 1382700003351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1382700003352 dimer interface [polypeptide binding]; other site 1382700003353 conserved gate region; other site 1382700003354 putative PBP binding loops; other site 1382700003355 ABC-ATPase subunit interface; other site 1382700003356 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 1382700003357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1382700003358 dimer interface [polypeptide binding]; other site 1382700003359 conserved gate region; other site 1382700003360 putative PBP binding loops; other site 1382700003361 ABC-ATPase subunit interface; other site 1382700003362 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1382700003363 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1382700003364 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1382700003365 gamma subunit interface [polypeptide binding]; other site 1382700003366 epsilon subunit interface [polypeptide binding]; other site 1382700003367 LBP interface [polypeptide binding]; other site 1382700003368 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1382700003369 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1382700003370 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1382700003371 alpha subunit interaction interface [polypeptide binding]; other site 1382700003372 Walker A motif; other site 1382700003373 ATP binding site [chemical binding]; other site 1382700003374 Walker B motif; other site 1382700003375 inhibitor binding site; inhibition site 1382700003376 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1382700003377 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1382700003378 core domain interface [polypeptide binding]; other site 1382700003379 delta subunit interface [polypeptide binding]; other site 1382700003380 epsilon subunit interface [polypeptide binding]; other site 1382700003381 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1382700003382 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1382700003383 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1382700003384 beta subunit interaction interface [polypeptide binding]; other site 1382700003385 Walker A motif; other site 1382700003386 ATP binding site [chemical binding]; other site 1382700003387 Walker B motif; other site 1382700003388 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1382700003389 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1382700003390 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1382700003391 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1382700003392 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1382700003393 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1382700003394 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1382700003395 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1382700003396 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 1382700003397 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1382700003398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1382700003399 S-adenosylmethionine binding site [chemical binding]; other site 1382700003400 FMN-binding protein MioC; Provisional; Region: PRK09004 1382700003401 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 1382700003402 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1382700003403 putative DNA binding site [nucleotide binding]; other site 1382700003404 putative Zn2+ binding site [ion binding]; other site 1382700003405 AsnC family; Region: AsnC_trans_reg; pfam01037 1382700003406 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 1382700003407 potassium uptake protein; Region: kup; TIGR00794 1382700003408 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1382700003409 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1382700003410 ligand binding site [chemical binding]; other site 1382700003411 dimerization interface [polypeptide binding]; other site 1382700003412 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1382700003413 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1382700003414 DNA-binding site [nucleotide binding]; DNA binding site 1382700003415 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1382700003416 transcriptional regulator HdfR; Provisional; Region: PRK03601 1382700003417 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1382700003418 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1382700003419 dimerization interface [polypeptide binding]; other site 1382700003420 hypothetical protein; Provisional; Region: PRK11027 1382700003421 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 1382700003422 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 1382700003423 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1382700003424 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1382700003425 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1382700003426 catalytic residues [active] 1382700003427 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1382700003428 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1382700003429 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1382700003430 RNA binding site [nucleotide binding]; other site 1382700003431 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1382700003432 multimer interface [polypeptide binding]; other site 1382700003433 Walker A motif; other site 1382700003434 ATP binding site [chemical binding]; other site 1382700003435 Walker B motif; other site 1382700003436 putative common antigen polymerase; Provisional; Region: PRK02975 1382700003437 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 1382700003438 HemY protein N-terminus; Region: HemY_N; pfam07219 1382700003439 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 1382700003440 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1382700003441 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1382700003442 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1382700003443 Predicted periplasmic protein [Function unknown]; Region: COG3698 1382700003444 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1382700003445 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1382700003446 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 1382700003447 Cl binding site [ion binding]; other site 1382700003448 oligomer interface [polypeptide binding]; other site 1382700003449 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 1382700003450 EamA-like transporter family; Region: EamA; cl17759 1382700003451 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 1382700003452 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1382700003453 ATP binding site [chemical binding]; other site 1382700003454 putative Mg++ binding site [ion binding]; other site 1382700003455 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1382700003456 nucleotide binding region [chemical binding]; other site 1382700003457 ATP-binding site [chemical binding]; other site 1382700003458 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1382700003459 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1382700003460 threonine efflux system; Provisional; Region: PRK10229 1382700003461 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 1382700003462 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1382700003463 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1382700003464 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1382700003465 putative dimerization interface [polypeptide binding]; other site 1382700003466 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1382700003467 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1382700003468 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1382700003469 active site turn [active] 1382700003470 phosphorylation site [posttranslational modification] 1382700003471 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1382700003472 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1382700003473 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1382700003474 dimerization interface [polypeptide binding]; other site 1382700003475 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 1382700003476 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1382700003477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1382700003478 S-adenosylmethionine binding site [chemical binding]; other site 1382700003479 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 1382700003480 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1382700003481 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 1382700003482 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 1382700003483 FMN reductase; Validated; Region: fre; PRK08051 1382700003484 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1382700003485 FAD binding pocket [chemical binding]; other site 1382700003486 FAD binding motif [chemical binding]; other site 1382700003487 phosphate binding motif [ion binding]; other site 1382700003488 beta-alpha-beta structure motif; other site 1382700003489 NAD binding pocket [chemical binding]; other site 1382700003490 proline dipeptidase; Provisional; Region: PRK13607 1382700003491 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1382700003492 active site 1382700003493 potassium transporter; Provisional; Region: PRK10750 1382700003494 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1382700003495 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1382700003496 Walker A motif; other site 1382700003497 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 1382700003498 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1382700003499 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1382700003500 catalytic residues [active] 1382700003501 hinge region; other site 1382700003502 alpha helical domain; other site 1382700003503 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1382700003504 G1 box; other site 1382700003505 GTP/Mg2+ binding site [chemical binding]; other site 1382700003506 Switch I region; other site 1382700003507 G2 box; other site 1382700003508 G3 box; other site 1382700003509 Switch II region; other site 1382700003510 G4 box; other site 1382700003511 G5 box; other site 1382700003512 glutamine synthetase; Provisional; Region: glnA; PRK09469 1382700003513 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1382700003514 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1382700003515 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1382700003516 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1382700003517 G1 box; other site 1382700003518 putative GEF interaction site [polypeptide binding]; other site 1382700003519 GTP/Mg2+ binding site [chemical binding]; other site 1382700003520 Switch I region; other site 1382700003521 G2 box; other site 1382700003522 G3 box; other site 1382700003523 Switch II region; other site 1382700003524 G4 box; other site 1382700003525 G5 box; other site 1382700003526 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1382700003527 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1382700003528 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1382700003529 putative oxidoreductase; Provisional; Region: PRK10083 1382700003530 NAD(P) binding site [chemical binding]; other site 1382700003531 hypothetical protein; Reviewed; Region: PRK01637 1382700003532 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1382700003533 putative active site [active] 1382700003534 dimerization interface [polypeptide binding]; other site 1382700003535 putative tRNAtyr binding site [nucleotide binding]; other site 1382700003536 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1382700003537 non-specific DNA binding site [nucleotide binding]; other site 1382700003538 salt bridge; other site 1382700003539 sequence-specific DNA binding site [nucleotide binding]; other site 1382700003540 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 1382700003541 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1382700003542 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 1382700003543 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1382700003544 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1382700003545 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1382700003546 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1382700003547 N- and C-terminal domain interface [polypeptide binding]; other site 1382700003548 active site 1382700003549 putative catalytic site [active] 1382700003550 metal binding site [ion binding]; metal-binding site 1382700003551 ATP binding site [chemical binding]; other site 1382700003552 rhamnulokinase; Provisional; Region: rhaB; PRK10640 1382700003553 carbohydrate binding site [chemical binding]; other site 1382700003554 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 1382700003555 two-component sensor protein; Provisional; Region: cpxA; PRK09470 1382700003556 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1382700003557 dimerization interface [polypeptide binding]; other site 1382700003558 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1382700003559 dimer interface [polypeptide binding]; other site 1382700003560 phosphorylation site [posttranslational modification] 1382700003561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1382700003562 ATP binding site [chemical binding]; other site 1382700003563 Mg2+ binding site [ion binding]; other site 1382700003564 G-X-G motif; other site 1382700003565 DksA-like zinc finger domain containing protein; Region: PHA00080 1382700003566 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 1382700003567 Phage holin family 2; Region: Phage_holin_2; pfam04550 1382700003568 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 1382700003569 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1382700003570 catalytic residue [active] 1382700003571 major tail tube protein; Provisional; Region: FII; PHA02600 1382700003572 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1382700003573 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 1382700003574 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1382700003575 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1382700003576 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1382700003577 active site 1382700003578 ADP/pyrophosphate binding site [chemical binding]; other site 1382700003579 dimerization interface [polypeptide binding]; other site 1382700003580 allosteric effector site; other site 1382700003581 fructose-1,6-bisphosphate binding site; other site 1382700003582 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1382700003583 triosephosphate isomerase; Provisional; Region: PRK14567 1382700003584 substrate binding site [chemical binding]; other site 1382700003585 dimer interface [polypeptide binding]; other site 1382700003586 catalytic triad [active] 1382700003587 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 1382700003588 Predicted membrane protein [Function unknown]; Region: COG3152 1382700003589 hypothetical protein; Provisional; Region: PRK09981 1382700003590 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1382700003591 Ligand Binding Site [chemical binding]; other site 1382700003592 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1382700003593 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1382700003594 putative active site [active] 1382700003595 glycerol kinase; Provisional; Region: glpK; PRK00047 1382700003596 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1382700003597 N- and C-terminal domain interface [polypeptide binding]; other site 1382700003598 active site 1382700003599 MgATP binding site [chemical binding]; other site 1382700003600 catalytic site [active] 1382700003601 metal binding site [ion binding]; metal-binding site 1382700003602 glycerol binding site [chemical binding]; other site 1382700003603 homotetramer interface [polypeptide binding]; other site 1382700003604 homodimer interface [polypeptide binding]; other site 1382700003605 FBP binding site [chemical binding]; other site 1382700003606 protein IIAGlc interface [polypeptide binding]; other site 1382700003607 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1382700003608 amphipathic channel; other site 1382700003609 Asn-Pro-Ala signature motifs; other site 1382700003610 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1382700003611 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1382700003612 DNA binding site [nucleotide binding] 1382700003613 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 1382700003614 domain linker motif; other site 1382700003615 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1382700003616 dimerization interface [polypeptide binding]; other site 1382700003617 ligand binding site [chemical binding]; other site 1382700003618 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1382700003619 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 1382700003620 dimerization interface [polypeptide binding]; other site 1382700003621 DNA binding site [nucleotide binding] 1382700003622 corepressor binding sites; other site 1382700003623 EamA-like transporter family; Region: EamA; pfam00892 1382700003624 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1382700003625 EamA-like transporter family; Region: EamA; pfam00892 1382700003626 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 1382700003627 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1382700003628 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1382700003629 active site 1382700003630 P-loop; other site 1382700003631 phosphorylation site [posttranslational modification] 1382700003632 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1382700003633 active site 1382700003634 P-loop; other site 1382700003635 phosphorylation site [posttranslational modification] 1382700003636 argininosuccinate lyase; Provisional; Region: PRK04833 1382700003637 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1382700003638 active sites [active] 1382700003639 tetramer interface [polypeptide binding]; other site 1382700003640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1382700003641 D-galactonate transporter; Region: 2A0114; TIGR00893 1382700003642 putative substrate translocation pore; other site 1382700003643 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1382700003644 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1382700003645 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1382700003646 dimerization interface [polypeptide binding]; other site 1382700003647 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1382700003648 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1382700003649 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1382700003650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1382700003651 metabolite-proton symporter; Region: 2A0106; TIGR00883 1382700003652 putative substrate translocation pore; other site 1382700003653 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1382700003654 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1382700003655 hypothetical protein; Provisional; Region: PRK11056 1382700003656 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1382700003657 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1382700003658 proposed active site lysine [active] 1382700003659 conserved cys residue [active] 1382700003660 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1382700003661 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 1382700003662 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1382700003663 active site pocket [active] 1382700003664 oxyanion hole [active] 1382700003665 catalytic triad [active] 1382700003666 active site nucleophile [active] 1382700003667 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1382700003668 active site 1382700003669 phosphorylation site [posttranslational modification] 1382700003670 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 1382700003671 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1382700003672 RNA binding surface [nucleotide binding]; other site 1382700003673 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1382700003674 probable active site [active] 1382700003675 hypothetical protein; Provisional; Region: PRK10515 1382700003676 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1382700003677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1382700003678 dimer interface [polypeptide binding]; other site 1382700003679 conserved gate region; other site 1382700003680 putative PBP binding loops; other site 1382700003681 ABC-ATPase subunit interface; other site 1382700003682 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 1382700003683 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1382700003684 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1382700003685 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 1382700003686 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1382700003687 Walker A/P-loop; other site 1382700003688 ATP binding site [chemical binding]; other site 1382700003689 Q-loop/lid; other site 1382700003690 ABC transporter signature motif; other site 1382700003691 Walker B; other site 1382700003692 D-loop; other site 1382700003693 H-loop/switch region; other site 1382700003694 TOBE domain; Region: TOBE_2; pfam08402 1382700003695 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1382700003696 trimer interface; other site 1382700003697 sugar binding site [chemical binding]; other site 1382700003698 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1382700003699 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1382700003700 putative acyl-acceptor binding pocket; other site 1382700003701 LexA repressor; Validated; Region: PRK00215 1382700003702 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1382700003703 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1382700003704 Catalytic site [active] 1382700003705 alanine racemase; Reviewed; Region: alr; PRK00053 1382700003706 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1382700003707 active site 1382700003708 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1382700003709 substrate binding site [chemical binding]; other site 1382700003710 catalytic residues [active] 1382700003711 dimer interface [polypeptide binding]; other site 1382700003712 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 1382700003713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1382700003714 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1382700003715 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1382700003716 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1382700003717 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1382700003718 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1382700003719 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1382700003720 dimer interface [polypeptide binding]; other site 1382700003721 ssDNA binding site [nucleotide binding]; other site 1382700003722 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1382700003723 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1382700003724 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1382700003725 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1382700003726 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 1382700003727 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 1382700003728 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1382700003729 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1382700003730 putative active site [active] 1382700003731 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 1382700003732 hypothetical protein; Provisional; Region: PRK10220 1382700003733 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1382700003734 PhnA protein; Region: PhnA; pfam03831 1382700003735 arginine:agmatin antiporter; Provisional; Region: PRK10644 1382700003736 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1382700003737 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1382700003738 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 1382700003739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1382700003740 active site 1382700003741 phosphorylation site [posttranslational modification] 1382700003742 intermolecular recognition site; other site 1382700003743 dimerization interface [polypeptide binding]; other site 1382700003744 Transcriptional regulator; Region: CitT; pfam12431 1382700003745 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1382700003746 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 1382700003747 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 1382700003748 putative transcriptional regulator; Provisional; Region: PRK11640 1382700003749 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1382700003750 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1382700003751 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1382700003752 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1382700003753 Aspartase; Region: Aspartase; cd01357 1382700003754 active sites [active] 1382700003755 tetramer interface [polypeptide binding]; other site 1382700003756 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1382700003757 oligomerisation interface [polypeptide binding]; other site 1382700003758 mobile loop; other site 1382700003759 roof hairpin; other site 1382700003760 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1382700003761 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1382700003762 ring oligomerisation interface [polypeptide binding]; other site 1382700003763 ATP/Mg binding site [chemical binding]; other site 1382700003764 stacking interactions; other site 1382700003765 hinge regions; other site 1382700003766 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1382700003767 elongation factor P; Validated; Region: PRK00529 1382700003768 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1382700003769 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1382700003770 RNA binding site [nucleotide binding]; other site 1382700003771 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1382700003772 RNA binding site [nucleotide binding]; other site 1382700003773 entericidin A; Provisional; Region: PRK09810 1382700003774 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 1382700003775 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 1382700003776 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1382700003777 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1382700003778 Iron-sulfur protein interface; other site 1382700003779 proximal quinone binding site [chemical binding]; other site 1382700003780 C-subunit interface; other site 1382700003781 distal quinone binding site; other site 1382700003782 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1382700003783 D-subunit interface [polypeptide binding]; other site 1382700003784 Iron-sulfur protein interface; other site 1382700003785 proximal quinone binding site [chemical binding]; other site 1382700003786 distal quinone binding site [chemical binding]; other site 1382700003787 poxB regulator PoxA; Provisional; Region: PRK09350 1382700003788 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1382700003789 motif 1; other site 1382700003790 dimer interface [polypeptide binding]; other site 1382700003791 active site 1382700003792 motif 2; other site 1382700003793 motif 3; other site 1382700003794 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1382700003795 catalytic site [active] 1382700003796 putative active site [active] 1382700003797 putative substrate binding site [chemical binding]; other site 1382700003798 dimer interface [polypeptide binding]; other site 1382700003799 bacterial Hfq-like; Region: Hfq; cd01716 1382700003800 hexamer interface [polypeptide binding]; other site 1382700003801 Sm1 motif; other site 1382700003802 RNA binding site [nucleotide binding]; other site 1382700003803 Sm2 motif; other site 1382700003804 GTPase HflX; Provisional; Region: PRK11058 1382700003805 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1382700003806 HflX GTPase family; Region: HflX; cd01878 1382700003807 G1 box; other site 1382700003808 GTP/Mg2+ binding site [chemical binding]; other site 1382700003809 Switch I region; other site 1382700003810 G2 box; other site 1382700003811 G3 box; other site 1382700003812 Switch II region; other site 1382700003813 G4 box; other site 1382700003814 G5 box; other site 1382700003815 FtsH protease regulator HflC; Provisional; Region: PRK11029 1382700003816 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1382700003817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 1382700003818 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1382700003819 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1382700003820 GDP-binding site [chemical binding]; other site 1382700003821 ACT binding site; other site 1382700003822 IMP binding site; other site 1382700003823 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1382700003824 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1382700003825 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1382700003826 PspA/IM30 family; Region: PspA_IM30; pfam04012 1382700003827 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1382700003828 transcriptional repressor UlaR; Provisional; Region: PRK13509 1382700003829 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1382700003830 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1382700003831 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1382700003832 active site 1382700003833 P-loop; other site 1382700003834 phosphorylation site [posttranslational modification] 1382700003835 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1382700003836 active site 1382700003837 phosphorylation site [posttranslational modification] 1382700003838 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1382700003839 active site 1382700003840 dimer interface [polypeptide binding]; other site 1382700003841 magnesium binding site [ion binding]; other site 1382700003842 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1382700003843 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1382700003844 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1382700003845 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1382700003846 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1382700003847 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1382700003848 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 1382700003849 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337 1382700003850 putative NAD(P) binding site [chemical binding]; other site 1382700003851 active site 1382700003852 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 1382700003853 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1382700003854 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1382700003855 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 1382700003856 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1382700003857 Hemerythrin-like domain; Region: Hr-like; cd12108 1382700003858 Fe binding site [ion binding]; other site 1382700003859 Predicted transcriptional regulators [Transcription]; Region: COG1733 1382700003860 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1382700003861 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1382700003862 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1382700003863 active site 1382700003864 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 1382700003865 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 1382700003866 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1382700003867 Domain of unknown function DUF21; Region: DUF21; pfam01595 1382700003868 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1382700003869 Transporter associated domain; Region: CorC_HlyC; smart01091 1382700003870 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1382700003871 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1382700003872 putative active site pocket [active] 1382700003873 dimerization interface [polypeptide binding]; other site 1382700003874 putative catalytic residue [active] 1382700003875 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1382700003876 dimer interface [polypeptide binding]; other site 1382700003877 substrate binding site [chemical binding]; other site 1382700003878 metal binding sites [ion binding]; metal-binding site 1382700003879 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1382700003880 AMP binding site [chemical binding]; other site 1382700003881 metal binding site [ion binding]; metal-binding site 1382700003882 active site 1382700003883 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1382700003884 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1382700003885 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1382700003886 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1382700003887 hypothetical protein; Provisional; Region: PRK05255 1382700003888 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 1382700003889 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1382700003890 FeS/SAM binding site; other site 1382700003891 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1382700003892 ATP cone domain; Region: ATP-cone; pfam03477 1382700003893 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1382700003894 effector binding site; other site 1382700003895 active site 1382700003896 Zn binding site [ion binding]; other site 1382700003897 glycine loop; other site 1382700003898 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1382700003899 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1382700003900 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1382700003901 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1382700003902 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1382700003903 motif II; other site 1382700003904 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1382700003905 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1382700003906 homotrimer interaction site [polypeptide binding]; other site 1382700003907 putative active site [active] 1382700003908 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 1382700003909 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 1382700003910 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 1382700003911 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 1382700003912 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1382700003913 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1382700003914 DNA polymerase III subunit chi; Validated; Region: PRK05728 1382700003915 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1382700003916 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1382700003917 interface (dimer of trimers) [polypeptide binding]; other site 1382700003918 Substrate-binding/catalytic site; other site 1382700003919 Zn-binding sites [ion binding]; other site 1382700003920 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 1382700003921 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1382700003922 NADP binding site [chemical binding]; other site 1382700003923 homodimer interface [polypeptide binding]; other site 1382700003924 active site 1382700003925 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 1382700003926 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 1382700003927 Fimbrial protein; Region: Fimbrial; cl01416 1382700003928 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 1382700003929 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1382700003930 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1382700003931 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1382700003932 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1382700003933 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 1382700003934 mannosyl binding site [chemical binding]; other site 1382700003935 Fimbrial protein; Region: Fimbrial; pfam00419 1382700003936 mannonate dehydratase; Region: uxuA; TIGR00695 1382700003937 mannonate dehydratase; Provisional; Region: PRK03906 1382700003938 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 1382700003939 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1382700003940 hypothetical protein; Provisional; Region: PRK10519 1382700003941 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 1382700003942 Uncharacterized small protein [Function unknown]; Region: COG2879 1382700003943 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1382700003944 DNA-binding site [nucleotide binding]; DNA binding site 1382700003945 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1382700003946 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1382700003947 DNA replication protein DnaC; Validated; Region: PRK07952 1382700003948 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1382700003949 Walker A motif; other site 1382700003950 ATP binding site [chemical binding]; other site 1382700003951 Walker B motif; other site 1382700003952 hypothetical protein; Provisional; Region: PRK09917 1382700003953 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1382700003954 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1382700003955 DNA binding residues [nucleotide binding] 1382700003956 dimerization interface [polypeptide binding]; other site 1382700003957 DNA polymerase III subunit psi; Validated; Region: PRK06856 1382700003958 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 1382700003959 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1382700003960 Coenzyme A binding pocket [chemical binding]; other site 1382700003961 periplasmic protein; Provisional; Region: PRK10568 1382700003962 BON domain; Region: BON; pfam04972 1382700003963 BON domain; Region: BON; pfam04972 1382700003964 DNA repair protein RadA; Region: sms; TIGR00416 1382700003965 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1382700003966 Walker A motif/ATP binding site; other site 1382700003967 ATP binding site [chemical binding]; other site 1382700003968 Walker B motif; other site 1382700003969 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1382700003970 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1382700003971 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1382700003972 Walker A/P-loop; other site 1382700003973 ATP binding site [chemical binding]; other site 1382700003974 Q-loop/lid; other site 1382700003975 ABC transporter signature motif; other site 1382700003976 Walker B; other site 1382700003977 D-loop; other site 1382700003978 H-loop/switch region; other site 1382700003979 ABC transporter; Region: ABC_tran_2; pfam12848 1382700003980 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1382700003981 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1382700003982 catalytic core [active] 1382700003983 hypothetical protein; Provisional; Region: PRK10756 1382700003984 CreA protein; Region: CreA; pfam05981 1382700003985 two-component response regulator; Provisional; Region: PRK11173 1382700003986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1382700003987 active site 1382700003988 phosphorylation site [posttranslational modification] 1382700003989 intermolecular recognition site; other site 1382700003990 dimerization interface [polypeptide binding]; other site 1382700003991 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1382700003992 DNA binding site [nucleotide binding] 1382700003993 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1382700003994 Catalytic site [active] 1382700003995 DinI-like family; Region: DinI; pfam06183