-- dump date 20140619_090646 -- class Genbank::misc_feature -- table misc_feature_note -- id note 585035000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 585035000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 585035000003 putative catalytic residues [active] 585035000004 putative nucleotide binding site [chemical binding]; other site 585035000005 putative aspartate binding site [chemical binding]; other site 585035000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 585035000007 dimer interface [polypeptide binding]; other site 585035000008 putative threonine allosteric regulatory site; other site 585035000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 585035000010 putative threonine allosteric regulatory site; other site 585035000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 585035000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 585035000013 homoserine kinase; Region: thrB; TIGR00191 585035000014 Protein of unknown function; Region: YhfT; pfam10797 585035000015 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 585035000016 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 585035000017 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 585035000018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035000019 catalytic residue [active] 585035000020 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 585035000021 hypothetical protein; Validated; Region: PRK02101 585035000022 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 585035000023 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 585035000024 transaldolase-like protein; Provisional; Region: PTZ00411 585035000025 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 585035000026 active site 585035000027 dimer interface [polypeptide binding]; other site 585035000028 catalytic residue [active] 585035000029 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 585035000030 MPT binding site; other site 585035000031 trimer interface [polypeptide binding]; other site 585035000032 hypothetical protein; Provisional; Region: PRK10659 585035000033 hypothetical protein; Provisional; Region: PRK10236 585035000034 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 585035000035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 585035000036 hypothetical protein; Provisional; Region: PRK10154 585035000037 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 585035000038 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 585035000039 nucleotide binding site [chemical binding]; other site 585035000040 NEF interaction site [polypeptide binding]; other site 585035000041 SBD interface [polypeptide binding]; other site 585035000042 chaperone protein DnaJ; Provisional; Region: PRK10767 585035000043 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 585035000044 HSP70 interaction site [polypeptide binding]; other site 585035000045 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 585035000046 substrate binding site [polypeptide binding]; other site 585035000047 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 585035000048 Zn binding sites [ion binding]; other site 585035000049 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 585035000050 dimer interface [polypeptide binding]; other site 585035000051 Hok/gef family; Region: HOK_GEF; pfam01848 585035000052 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 585035000053 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 585035000054 Sulfatase; Region: Sulfatase; pfam00884 585035000055 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 585035000056 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 585035000057 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035000058 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 585035000059 putative dimerization interface [polypeptide binding]; other site 585035000060 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 585035000061 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 585035000062 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 585035000063 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 585035000064 active site 585035000065 Riboflavin kinase; Region: Flavokinase; smart00904 585035000066 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 585035000067 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 585035000068 HIGH motif; other site 585035000069 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 585035000070 active site 585035000071 KMSKS motif; other site 585035000072 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 585035000073 tRNA binding surface [nucleotide binding]; other site 585035000074 anticodon binding site; other site 585035000075 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 585035000076 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 585035000077 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 585035000078 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 585035000079 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 585035000080 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 585035000081 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 585035000082 active site 585035000083 tetramer interface [polypeptide binding]; other site 585035000084 Protein of unknown function (DUF805); Region: DUF805; pfam05656 585035000085 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 585035000086 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 585035000087 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 585035000088 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 585035000089 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 585035000090 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 585035000091 catalytic site [active] 585035000092 subunit interface [polypeptide binding]; other site 585035000093 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 585035000094 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 585035000095 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 585035000096 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 585035000097 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 585035000098 ATP-grasp domain; Region: ATP-grasp_4; cl17255 585035000099 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 585035000100 IMP binding site; other site 585035000101 dimer interface [polypeptide binding]; other site 585035000102 interdomain contacts; other site 585035000103 partial ornithine binding site; other site 585035000104 Transposase IS200 like; Region: Y1_Tnp; pfam01797 585035000105 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 585035000106 carnitine operon protein CaiE; Provisional; Region: PRK13627 585035000107 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 585035000108 putative trimer interface [polypeptide binding]; other site 585035000109 putative metal binding site [ion binding]; other site 585035000110 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 585035000111 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585035000112 substrate binding site [chemical binding]; other site 585035000113 oxyanion hole (OAH) forming residues; other site 585035000114 trimer interface [polypeptide binding]; other site 585035000115 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 585035000116 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 585035000117 acyl-activating enzyme (AAE) consensus motif; other site 585035000118 putative AMP binding site [chemical binding]; other site 585035000119 putative active site [active] 585035000120 putative CoA binding site [chemical binding]; other site 585035000121 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 585035000122 CoA-transferase family III; Region: CoA_transf_3; pfam02515 585035000123 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 585035000124 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 585035000125 active site 585035000126 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 585035000127 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 585035000128 Ligand binding site [chemical binding]; other site 585035000129 Electron transfer flavoprotein domain; Region: ETF; pfam01012 585035000130 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 585035000131 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 585035000132 Ligand binding site [chemical binding]; other site 585035000133 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 585035000134 putative oxidoreductase FixC; Provisional; Region: PRK10157 585035000135 ferredoxin-like protein FixX; Provisional; Region: PRK15449 585035000136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035000137 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 585035000138 putative substrate translocation pore; other site 585035000139 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 585035000140 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 585035000141 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 585035000142 TrkA-N domain; Region: TrkA_N; pfam02254 585035000143 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 585035000144 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 585035000145 folate binding site [chemical binding]; other site 585035000146 NADP+ binding site [chemical binding]; other site 585035000147 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 585035000148 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; toxin of gyrase inhibiting toxin-antitoxin system (partial) 585035000149 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 585035000150 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 585035000151 active site 585035000152 metal binding site [ion binding]; metal-binding site 585035000153 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 585035000154 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 585035000155 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 585035000156 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 585035000157 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 585035000158 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 585035000159 SurA N-terminal domain; Region: SurA_N; pfam09312 585035000160 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 585035000161 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 585035000162 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 585035000163 OstA-like protein; Region: OstA; pfam03968 585035000164 Organic solvent tolerance protein; Region: OstA_C; pfam04453 585035000165 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 585035000166 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 585035000167 putative metal binding site [ion binding]; other site 585035000168 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 585035000169 HSP70 interaction site [polypeptide binding]; other site 585035000170 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 585035000171 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 585035000172 active site 585035000173 ATP-dependent helicase HepA; Validated; Region: PRK04914 585035000174 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585035000175 ATP binding site [chemical binding]; other site 585035000176 putative Mg++ binding site [ion binding]; other site 585035000177 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585035000178 nucleotide binding region [chemical binding]; other site 585035000179 ATP-binding site [chemical binding]; other site 585035000180 DNA polymerase II; Reviewed; Region: PRK05762 585035000181 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 585035000182 active site 585035000183 catalytic site [active] 585035000184 substrate binding site [chemical binding]; other site 585035000185 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 585035000186 active site 585035000187 metal-binding site 585035000188 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 585035000189 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 585035000190 intersubunit interface [polypeptide binding]; other site 585035000191 active site 585035000192 Zn2+ binding site [ion binding]; other site 585035000193 L-arabinose isomerase; Provisional; Region: PRK02929 585035000194 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 585035000195 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 585035000196 trimer interface [polypeptide binding]; other site 585035000197 putative substrate binding site [chemical binding]; other site 585035000198 putative metal binding site [ion binding]; other site 585035000199 ribulokinase; Provisional; Region: PRK04123 585035000200 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 585035000201 N- and C-terminal domain interface [polypeptide binding]; other site 585035000202 active site 585035000203 MgATP binding site [chemical binding]; other site 585035000204 catalytic site [active] 585035000205 metal binding site [ion binding]; metal-binding site 585035000206 carbohydrate binding site [chemical binding]; other site 585035000207 homodimer interface [polypeptide binding]; other site 585035000208 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 585035000209 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 585035000210 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035000211 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035000212 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 585035000213 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 585035000214 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 585035000215 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 585035000216 Walker A/P-loop; other site 585035000217 ATP binding site [chemical binding]; other site 585035000218 Q-loop/lid; other site 585035000219 ABC transporter signature motif; other site 585035000220 Walker B; other site 585035000221 D-loop; other site 585035000222 H-loop/switch region; other site 585035000223 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 585035000224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035000225 dimer interface [polypeptide binding]; other site 585035000226 conserved gate region; other site 585035000227 putative PBP binding loops; other site 585035000228 ABC-ATPase subunit interface; other site 585035000229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035000230 dimer interface [polypeptide binding]; other site 585035000231 conserved gate region; other site 585035000232 putative PBP binding loops; other site 585035000233 ABC-ATPase subunit interface; other site 585035000234 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 585035000235 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 585035000236 transcriptional regulator SgrR; Provisional; Region: PRK13626 585035000237 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 585035000238 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 585035000239 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 585035000240 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 585035000241 substrate binding site [chemical binding]; other site 585035000242 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 585035000243 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 585035000244 substrate binding site [chemical binding]; other site 585035000245 ligand binding site [chemical binding]; other site 585035000246 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 585035000247 tartrate dehydrogenase; Region: TTC; TIGR02089 585035000248 2-isopropylmalate synthase; Validated; Region: PRK00915 585035000249 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 585035000250 active site 585035000251 catalytic residues [active] 585035000252 metal binding site [ion binding]; metal-binding site 585035000253 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 585035000254 leu operon leader peptide; Provisional; Region: PRK09925 585035000255 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 585035000256 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035000257 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 585035000258 putative substrate binding pocket [chemical binding]; other site 585035000259 putative dimerization interface [polypeptide binding]; other site 585035000260 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 585035000261 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 585035000262 PYR/PP interface [polypeptide binding]; other site 585035000263 dimer interface [polypeptide binding]; other site 585035000264 TPP binding site [chemical binding]; other site 585035000265 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 585035000266 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 585035000267 TPP-binding site [chemical binding]; other site 585035000268 dimer interface [polypeptide binding]; other site 585035000269 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 585035000270 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 585035000271 putative valine binding site [chemical binding]; other site 585035000272 dimer interface [polypeptide binding]; other site 585035000273 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 585035000274 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 585035000275 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585035000276 DNA binding site [nucleotide binding] 585035000277 domain linker motif; other site 585035000278 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 585035000279 dimerization interface [polypeptide binding]; other site 585035000280 ligand binding site [chemical binding]; other site 585035000281 mraZ protein; Region: TIGR00242 585035000282 MraZ protein; Region: MraZ; pfam02381 585035000283 MraZ protein; Region: MraZ; pfam02381 585035000284 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 585035000285 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 585035000286 cell division protein FtsL; Provisional; Region: PRK10772 585035000287 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 585035000288 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 585035000289 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 585035000290 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 585035000291 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 585035000292 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 585035000293 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 585035000294 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 585035000295 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 585035000296 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 585035000297 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 585035000298 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 585035000299 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 585035000300 Mg++ binding site [ion binding]; other site 585035000301 putative catalytic motif [active] 585035000302 putative substrate binding site [chemical binding]; other site 585035000303 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 585035000304 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 585035000305 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 585035000306 cell division protein FtsW; Provisional; Region: PRK10774 585035000307 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 585035000308 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 585035000309 active site 585035000310 homodimer interface [polypeptide binding]; other site 585035000311 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 585035000312 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 585035000313 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 585035000314 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 585035000315 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 585035000316 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 585035000317 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 585035000318 cell division protein FtsQ; Provisional; Region: PRK10775 585035000319 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 585035000320 Cell division protein FtsQ; Region: FtsQ; pfam03799 585035000321 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 585035000322 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585035000323 Cell division protein FtsA; Region: FtsA; pfam14450 585035000324 cell division protein FtsZ; Validated; Region: PRK09330 585035000325 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 585035000326 nucleotide binding site [chemical binding]; other site 585035000327 SulA interaction site; other site 585035000328 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 585035000329 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 585035000330 SecA regulator SecM; Provisional; Region: PRK02943 585035000331 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 585035000332 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 585035000333 SEC-C motif; Region: SEC-C; pfam02810 585035000334 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 585035000335 active site 585035000336 8-oxo-dGMP binding site [chemical binding]; other site 585035000337 nudix motif; other site 585035000338 metal binding site [ion binding]; metal-binding site 585035000339 DNA gyrase inhibitor; Reviewed; Region: PRK00418 585035000340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 585035000341 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 585035000342 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 585035000343 CoA-binding site [chemical binding]; other site 585035000344 ATP-binding [chemical binding]; other site 585035000345 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 585035000346 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 585035000347 active site 585035000348 type IV pilin biogenesis protein; Provisional; Region: PRK10573 585035000349 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 585035000350 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 585035000351 hypothetical protein; Provisional; Region: PRK10436 585035000352 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 585035000353 Walker A motif; other site 585035000354 ATP binding site [chemical binding]; other site 585035000355 Walker B motif; other site 585035000356 putative major pilin subunit; Provisional; Region: PRK10574 585035000357 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 585035000358 Pilin (bacterial filament); Region: Pilin; pfam00114 585035000359 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 585035000360 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 585035000361 dimerization interface [polypeptide binding]; other site 585035000362 active site 585035000363 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 585035000364 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 585035000365 amidase catalytic site [active] 585035000366 Zn binding residues [ion binding]; other site 585035000367 substrate binding site [chemical binding]; other site 585035000368 regulatory protein AmpE; Provisional; Region: PRK10987 585035000369 aromatic amino acid transporter; Provisional; Region: PRK10238 585035000370 Protein of unknown function (DUF796); Region: DUF796; cl01226 585035000371 S-type Pyocin; Region: Pyocin_S; pfam06958 585035000372 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 585035000373 active site 585035000374 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 585035000375 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10702359 585035000376 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 585035000377 Evidence 4 : Homologs of previously reported genes of unknown function 585035000378 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 585035000379 Transcriptional regulators [Transcription]; Region: FadR; COG2186 585035000380 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585035000381 DNA-binding site [nucleotide binding]; DNA binding site 585035000382 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585035000383 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 585035000384 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 585035000385 dimer interface [polypeptide binding]; other site 585035000386 TPP-binding site [chemical binding]; other site 585035000387 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 585035000388 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 585035000389 E3 interaction surface; other site 585035000390 lipoyl attachment site [posttranslational modification]; other site 585035000391 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 585035000392 E3 interaction surface; other site 585035000393 lipoyl attachment site [posttranslational modification]; other site 585035000394 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 585035000395 E3 interaction surface; other site 585035000396 lipoyl attachment site [posttranslational modification]; other site 585035000397 e3 binding domain; Region: E3_binding; pfam02817 585035000398 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 585035000399 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 585035000400 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 585035000401 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585035000402 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 585035000403 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 585035000404 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 585035000405 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 585035000406 substrate binding site [chemical binding]; other site 585035000407 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 585035000408 substrate binding site [chemical binding]; other site 585035000409 ligand binding site [chemical binding]; other site 585035000410 hypothetical protein; Provisional; Region: PRK05248 585035000411 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 585035000412 spermidine synthase; Provisional; Region: PRK00811 585035000413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035000414 S-adenosylmethionine binding site [chemical binding]; other site 585035000415 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 585035000416 multicopper oxidase; Provisional; Region: PRK10965 585035000417 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 585035000418 Multicopper oxidase; Region: Cu-oxidase; pfam00394 585035000419 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 585035000420 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 585035000421 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 585035000422 Trp docking motif [polypeptide binding]; other site 585035000423 putative active site [active] 585035000424 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585035000425 active site 585035000426 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 585035000427 active site clefts [active] 585035000428 zinc binding site [ion binding]; other site 585035000429 dimer interface [polypeptide binding]; other site 585035000430 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 585035000431 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 585035000432 Walker A/P-loop; other site 585035000433 ATP binding site [chemical binding]; other site 585035000434 Q-loop/lid; other site 585035000435 ABC transporter signature motif; other site 585035000436 Walker B; other site 585035000437 D-loop; other site 585035000438 H-loop/switch region; other site 585035000439 inner membrane transport permease; Provisional; Region: PRK15066 585035000440 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 585035000441 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 585035000442 active pocket/dimerization site; other site 585035000443 active site 585035000444 phosphorylation site [posttranslational modification] 585035000445 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 585035000446 putative active site [active] 585035000447 putative metal binding site [ion binding]; other site 585035000448 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 585035000449 tetramerization interface [polypeptide binding]; other site 585035000450 active site 585035000451 Uncharacterized conserved protein [Function unknown]; Region: COG5464 585035000452 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 585035000453 pantoate--beta-alanine ligase; Region: panC; TIGR00018 585035000454 Pantoate-beta-alanine ligase; Region: PanC; cd00560 585035000455 active site 585035000456 ATP-binding site [chemical binding]; other site 585035000457 pantoate-binding site; other site 585035000458 HXXH motif; other site 585035000459 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 585035000460 oligomerization interface [polypeptide binding]; other site 585035000461 active site 585035000462 metal binding site [ion binding]; metal-binding site 585035000463 putative fimbrial-like adhesin protein; Provisional; Region: PRK09723 585035000464 putative fimbrial protein StaF; Provisional; Region: PRK15262 585035000465 putative fimbrial protein StaE; Provisional; Region: PRK15263 585035000466 Fimbrial protein; Region: Fimbrial; cl01416 585035000467 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 585035000468 PapC N-terminal domain; Region: PapC_N; pfam13954 585035000469 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585035000470 PapC C-terminal domain; Region: PapC_C; pfam13953 585035000471 putative chaperone protein EcpD; Provisional; Region: PRK09926 585035000472 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585035000473 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585035000474 Fimbrial protein; Region: Fimbrial; cl01416 585035000475 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 585035000476 catalytic center binding site [active] 585035000477 ATP binding site [chemical binding]; other site 585035000478 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 585035000479 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 585035000480 active site 585035000481 NTP binding site [chemical binding]; other site 585035000482 metal binding triad [ion binding]; metal-binding site 585035000483 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 585035000484 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 585035000485 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 585035000486 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 585035000487 active site 585035000488 nucleotide binding site [chemical binding]; other site 585035000489 HIGH motif; other site 585035000490 KMSKS motif; other site 585035000491 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 585035000492 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 585035000493 2'-5' RNA ligase; Provisional; Region: PRK15124 585035000494 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 585035000495 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 585035000496 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 585035000497 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585035000498 ATP binding site [chemical binding]; other site 585035000499 putative Mg++ binding site [ion binding]; other site 585035000500 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585035000501 nucleotide binding region [chemical binding]; other site 585035000502 ATP-binding site [chemical binding]; other site 585035000503 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 585035000504 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 585035000505 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 585035000506 Transglycosylase; Region: Transgly; pfam00912 585035000507 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 585035000508 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 585035000509 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585035000510 N-terminal plug; other site 585035000511 ligand-binding site [chemical binding]; other site 585035000512 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 585035000513 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 585035000514 Walker A/P-loop; other site 585035000515 ATP binding site [chemical binding]; other site 585035000516 Q-loop/lid; other site 585035000517 ABC transporter signature motif; other site 585035000518 Walker B; other site 585035000519 D-loop; other site 585035000520 H-loop/switch region; other site 585035000521 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 585035000522 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 585035000523 siderophore binding site; other site 585035000524 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 585035000525 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585035000526 ABC-ATPase subunit interface; other site 585035000527 dimer interface [polypeptide binding]; other site 585035000528 putative PBP binding regions; other site 585035000529 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585035000530 ABC-ATPase subunit interface; other site 585035000531 dimer interface [polypeptide binding]; other site 585035000532 putative PBP binding regions; other site 585035000533 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 585035000534 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585035000535 inhibitor-cofactor binding pocket; inhibition site 585035000536 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035000537 catalytic residue [active] 585035000538 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 585035000539 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 585035000540 Cl- selectivity filter; other site 585035000541 Cl- binding residues [ion binding]; other site 585035000542 pore gating glutamate residue; other site 585035000543 dimer interface [polypeptide binding]; other site 585035000544 H+/Cl- coupling transport residue; other site 585035000545 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 585035000546 hypothetical protein; Provisional; Region: PRK10578 585035000547 UPF0126 domain; Region: UPF0126; pfam03458 585035000548 UPF0126 domain; Region: UPF0126; pfam03458 585035000549 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 585035000550 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 585035000551 cobalamin binding residues [chemical binding]; other site 585035000552 putative BtuC binding residues; other site 585035000553 dimer interface [polypeptide binding]; other site 585035000554 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 585035000555 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 585035000556 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 585035000557 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 585035000558 Zn2+ binding site [ion binding]; other site 585035000559 Mg2+ binding site [ion binding]; other site 585035000560 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 585035000561 serine endoprotease; Provisional; Region: PRK10942 585035000562 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 585035000563 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 585035000564 protein binding site [polypeptide binding]; other site 585035000565 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 585035000566 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 585035000567 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 585035000568 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 585035000569 hypothetical protein; Provisional; Region: PRK13677 585035000570 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 585035000571 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 585035000572 trimer interface [polypeptide binding]; other site 585035000573 active site 585035000574 substrate binding site [chemical binding]; other site 585035000575 CoA binding site [chemical binding]; other site 585035000576 PII uridylyl-transferase; Provisional; Region: PRK05007 585035000577 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 585035000578 metal binding triad; other site 585035000579 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 585035000580 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 585035000581 Zn2+ binding site [ion binding]; other site 585035000582 Mg2+ binding site [ion binding]; other site 585035000583 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 585035000584 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 585035000585 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 585035000586 active site 585035000587 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 585035000588 rRNA interaction site [nucleotide binding]; other site 585035000589 S8 interaction site; other site 585035000590 putative laminin-1 binding site; other site 585035000591 elongation factor Ts; Provisional; Region: tsf; PRK09377 585035000592 UBA/TS-N domain; Region: UBA; pfam00627 585035000593 Elongation factor TS; Region: EF_TS; pfam00889 585035000594 Elongation factor TS; Region: EF_TS; pfam00889 585035000595 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 585035000596 putative nucleotide binding site [chemical binding]; other site 585035000597 uridine monophosphate binding site [chemical binding]; other site 585035000598 homohexameric interface [polypeptide binding]; other site 585035000599 ribosome recycling factor; Reviewed; Region: frr; PRK00083 585035000600 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 585035000601 hinge region; other site 585035000602 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 585035000603 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 585035000604 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 585035000605 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 585035000606 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 585035000607 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 585035000608 catalytic residue [active] 585035000609 putative FPP diphosphate binding site; other site 585035000610 putative FPP binding hydrophobic cleft; other site 585035000611 dimer interface [polypeptide binding]; other site 585035000612 putative IPP diphosphate binding site; other site 585035000613 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 585035000614 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 585035000615 zinc metallopeptidase RseP; Provisional; Region: PRK10779 585035000616 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 585035000617 active site 585035000618 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 585035000619 protein binding site [polypeptide binding]; other site 585035000620 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 585035000621 putative substrate binding region [chemical binding]; other site 585035000622 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 585035000623 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 585035000624 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 585035000625 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 585035000626 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 585035000627 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 585035000628 Surface antigen; Region: Bac_surface_Ag; pfam01103 585035000629 periplasmic chaperone; Provisional; Region: PRK10780 585035000630 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 585035000631 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 585035000632 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 585035000633 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 585035000634 trimer interface [polypeptide binding]; other site 585035000635 active site 585035000636 UDP-GlcNAc binding site [chemical binding]; other site 585035000637 lipid binding site [chemical binding]; lipid-binding site 585035000638 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 585035000639 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 585035000640 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 585035000641 active site 585035000642 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 585035000643 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 585035000644 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 585035000645 RNA/DNA hybrid binding site [nucleotide binding]; other site 585035000646 active site 585035000647 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 585035000648 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 585035000649 putative active site [active] 585035000650 putative PHP Thumb interface [polypeptide binding]; other site 585035000651 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 585035000652 generic binding surface II; other site 585035000653 generic binding surface I; other site 585035000654 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 585035000655 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 585035000656 lysine decarboxylase LdcC; Provisional; Region: PRK15399 585035000657 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 585035000658 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 585035000659 homodimer interface [polypeptide binding]; other site 585035000660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035000661 catalytic residue [active] 585035000662 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 585035000663 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 585035000664 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 585035000665 putative metal binding site [ion binding]; other site 585035000666 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 585035000667 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 585035000668 Ligand Binding Site [chemical binding]; other site 585035000669 TilS substrate binding domain; Region: TilS; pfam09179 585035000670 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 585035000671 Rho-binding antiterminator; Provisional; Region: PRK11625 585035000672 hypothetical protein; Provisional; Region: PRK04964 585035000673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 585035000674 hypothetical protein; Provisional; Region: PRK09256 585035000675 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 585035000676 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 585035000677 NlpE N-terminal domain; Region: NlpE; pfam04170 585035000678 hypothetical protein; Provisional; Region: PRK11479 585035000679 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 585035000680 prolyl-tRNA synthetase; Provisional; Region: PRK09194 585035000681 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 585035000682 dimer interface [polypeptide binding]; other site 585035000683 motif 1; other site 585035000684 active site 585035000685 motif 2; other site 585035000686 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 585035000687 putative deacylase active site [active] 585035000688 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 585035000689 active site 585035000690 motif 3; other site 585035000691 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 585035000692 anticodon binding site; other site 585035000693 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 585035000694 homodimer interaction site [polypeptide binding]; other site 585035000695 cofactor binding site; other site 585035000696 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 585035000697 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 585035000698 lipoprotein, YaeC family; Region: TIGR00363 585035000699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035000700 dimer interface [polypeptide binding]; other site 585035000701 conserved gate region; other site 585035000702 ABC-ATPase subunit interface; other site 585035000703 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 585035000704 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 585035000705 Walker A/P-loop; other site 585035000706 ATP binding site [chemical binding]; other site 585035000707 Q-loop/lid; other site 585035000708 ABC transporter signature motif; other site 585035000709 Walker B; other site 585035000710 D-loop; other site 585035000711 H-loop/switch region; other site 585035000712 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 585035000713 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 585035000714 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585035000715 active site 585035000716 motif I; other site 585035000717 motif II; other site 585035000718 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585035000719 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585035000720 active site 585035000721 catalytic tetrad [active] 585035000722 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585035000723 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035000724 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 585035000725 putative effector binding pocket; other site 585035000726 dimerization interface [polypeptide binding]; other site 585035000727 hypothetical protein; Provisional; Region: PRK05421 585035000728 putative catalytic site [active] 585035000729 putative metal binding site [ion binding]; other site 585035000730 putative phosphate binding site [ion binding]; other site 585035000731 putative catalytic site [active] 585035000732 putative phosphate binding site [ion binding]; other site 585035000733 putative metal binding site [ion binding]; other site 585035000734 Methyltransferase domain; Region: Methyltransf_31; pfam13847 585035000735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035000736 S-adenosylmethionine binding site [chemical binding]; other site 585035000737 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 585035000738 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585035000739 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585035000740 catalytic residue [active] 585035000741 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585035000742 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585035000743 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 585035000744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035000745 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 585035000746 RNA/DNA hybrid binding site [nucleotide binding]; other site 585035000747 active site 585035000748 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 585035000749 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 585035000750 active site 585035000751 catalytic site [active] 585035000752 substrate binding site [chemical binding]; other site 585035000753 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 585035000754 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 585035000755 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 585035000756 ImpA domain protein; Region: DUF3702; pfam12486 585035000757 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 585035000758 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 585035000759 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 585035000760 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 585035000761 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 585035000762 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 585035000763 type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360 585035000764 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 585035000765 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035000766 Walker A motif; other site 585035000767 ATP binding site [chemical binding]; other site 585035000768 Walker B motif; other site 585035000769 arginine finger; other site 585035000770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035000771 Walker A motif; other site 585035000772 ATP binding site [chemical binding]; other site 585035000773 Walker B motif; other site 585035000774 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 585035000775 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 585035000776 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 585035000777 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 585035000778 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 585035000779 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 585035000780 FHA domain; Region: FHA; pfam00498 585035000781 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 585035000782 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 585035000783 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 585035000784 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 585035000785 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 585035000786 Protein of unknown function (DUF877); Region: DUF877; pfam05943 585035000787 Protein of unknown function (DUF770); Region: DUF770; pfam05591 585035000788 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 585035000789 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 585035000790 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 585035000791 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 585035000792 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 585035000793 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 585035000794 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 585035000795 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 585035000796 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 585035000797 putative active site [active] 585035000798 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 585035000799 Transposase [DNA replication, recombination, and repair]; Region: COG5433 585035000800 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 585035000801 C-N hydrolase family amidase; Provisional; Region: PRK10438 585035000802 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 585035000803 putative active site [active] 585035000804 catalytic triad [active] 585035000805 dimer interface [polypeptide binding]; other site 585035000806 multimer interface [polypeptide binding]; other site 585035000807 C-lysozyme inhibitor; Provisional; Region: PRK09993 585035000808 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 585035000809 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 585035000810 active site 585035000811 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 585035000812 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 585035000813 dimer interface [polypeptide binding]; other site 585035000814 active site 585035000815 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 585035000816 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 585035000817 putative active site [active] 585035000818 putative dimer interface [polypeptide binding]; other site 585035000819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 585035000820 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585035000821 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585035000822 NlpC/P60 family; Region: NLPC_P60; pfam00877 585035000823 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 585035000824 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 585035000825 FHIPEP family; Region: FHIPEP; pfam00771 585035000826 hypothetical protein; Validated; Region: PRK06778 585035000827 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585035000828 ligand binding site [chemical binding]; other site 585035000829 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 585035000830 active site 585035000831 DNA polymerase IV; Validated; Region: PRK02406 585035000832 DNA binding site [nucleotide binding] 585035000833 putative antitoxin of the YafO-YafN toxin-antitoxin system; Provisional; Region: PRK09778 585035000834 putative toxin YafO; Provisional; Region: PRK09885 585035000835 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 585035000836 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585035000837 Coenzyme A binding pocket [chemical binding]; other site 585035000838 hypothetical protein; Reviewed; Region: PRK09588 585035000839 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 585035000840 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 585035000841 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 585035000842 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 585035000843 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 585035000844 metal binding site [ion binding]; metal-binding site 585035000845 dimer interface [polypeptide binding]; other site 585035000846 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585035000847 active site 585035000848 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 585035000849 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 585035000850 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585035000851 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 585035000852 trimer interface [polypeptide binding]; other site 585035000853 eyelet of channel; other site 585035000854 gamma-glutamyl kinase; Provisional; Region: PRK05429 585035000855 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 585035000856 nucleotide binding site [chemical binding]; other site 585035000857 homotetrameric interface [polypeptide binding]; other site 585035000858 putative phosphate binding site [ion binding]; other site 585035000859 putative allosteric binding site; other site 585035000860 PUA domain; Region: PUA; pfam01472 585035000861 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 585035000862 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 585035000863 putative catalytic cysteine [active] 585035000864 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 585035000865 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 585035000866 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 585035000867 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 585035000868 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 585035000869 Autotransporter beta-domain; Region: Autotransporter; pfam03797 585035000870 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585035000871 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585035000872 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585035000873 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 585035000874 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 585035000875 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585035000876 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 585035000877 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 585035000878 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585035000879 DNA binding residues [nucleotide binding] 585035000880 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 585035000881 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 585035000882 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 585035000883 putative active site [active] 585035000884 putative FMN binding site [chemical binding]; other site 585035000885 putative substrate binding site [chemical binding]; other site 585035000886 putative catalytic residue [active] 585035000887 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 585035000888 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585035000889 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035000890 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 585035000891 putative effector binding pocket; other site 585035000892 putative dimerization interface [polypeptide binding]; other site 585035000893 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585035000894 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035000895 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 585035000896 putative effector binding pocket; other site 585035000897 putative dimerization interface [polypeptide binding]; other site 585035000898 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585035000899 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585035000900 active site 585035000901 catalytic tetrad [active] 585035000902 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585035000903 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585035000904 active site 585035000905 catalytic tetrad [active] 585035000906 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 585035000907 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 585035000908 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 585035000909 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 585035000910 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 585035000911 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 585035000912 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035000913 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 585035000914 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585035000915 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585035000916 active site 585035000917 catalytic tetrad [active] 585035000918 Predicted membrane protein [Function unknown]; Region: COG3059 585035000919 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585035000920 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 585035000921 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 585035000922 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585035000923 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 585035000924 Cupin; Region: Cupin_6; pfam12852 585035000925 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 585035000926 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035000927 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 585035000928 Cysteine-rich domain; Region: CCG; pfam02754 585035000929 Cysteine-rich domain; Region: CCG; pfam02754 585035000930 iron-sulfur cluster-binding protein; Region: TIGR00273 585035000931 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 585035000932 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585035000933 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 585035000934 Uncharacterized conserved protein [Function unknown]; Region: COG1556 585035000935 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 585035000936 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 585035000937 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 585035000938 Autotransporter beta-domain; Region: Autotransporter; pfam03797 585035000939 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 585035000940 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585035000941 DNA binding residues [nucleotide binding] 585035000942 dimerization interface [polypeptide binding]; other site 585035000943 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 585035000944 active site 585035000945 DNA binding site [nucleotide binding] 585035000946 Int/Topo IB signature motif; other site 585035000947 choline dehydrogenase; Validated; Region: PRK02106 585035000948 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 585035000949 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 585035000950 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 585035000951 tetrameric interface [polypeptide binding]; other site 585035000952 NAD binding site [chemical binding]; other site 585035000953 catalytic residues [active] 585035000954 transcriptional regulator BetI; Validated; Region: PRK00767 585035000955 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585035000956 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 585035000957 choline transport protein BetT; Provisional; Region: PRK09928 585035000958 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585035000959 DNA binding residues [nucleotide binding] 585035000960 dimerization interface [polypeptide binding]; other site 585035000961 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585035000962 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 585035000963 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035000964 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585035000965 dimerization interface [polypeptide binding]; other site 585035000966 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 585035000967 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 585035000968 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 585035000969 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 585035000970 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 585035000971 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 585035000972 CoA binding domain; Region: CoA_binding; pfam02629 585035000973 CoA-ligase; Region: Ligase_CoA; pfam00549 585035000974 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 585035000975 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 585035000976 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 585035000977 putative substrate binding site [chemical binding]; other site 585035000978 nucleotide binding site [chemical binding]; other site 585035000979 nucleotide binding site [chemical binding]; other site 585035000980 homodimer interface [polypeptide binding]; other site 585035000981 putative deaminase; Validated; Region: PRK06846 585035000982 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 585035000983 active site 585035000984 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 585035000985 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 585035000986 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 585035000987 ligand binding site [chemical binding]; other site 585035000988 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 585035000989 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585035000990 Walker A/P-loop; other site 585035000991 ATP binding site [chemical binding]; other site 585035000992 Q-loop/lid; other site 585035000993 ABC transporter signature motif; other site 585035000994 Walker B; other site 585035000995 D-loop; other site 585035000996 H-loop/switch region; other site 585035000997 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585035000998 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585035000999 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585035001000 TM-ABC transporter signature motif; other site 585035001001 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585035001002 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585035001003 TM-ABC transporter signature motif; other site 585035001004 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 585035001005 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 585035001006 putative NAD(P) binding site [chemical binding]; other site 585035001007 putative substrate binding site [chemical binding]; other site 585035001008 catalytic Zn binding site [ion binding]; other site 585035001009 structural Zn binding site [ion binding]; other site 585035001010 dimer interface [polypeptide binding]; other site 585035001011 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 585035001012 hypothetical protein; Provisional; Region: PRK09929 585035001013 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 585035001014 Propionate catabolism activator; Region: PrpR_N; pfam06506 585035001015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035001016 Walker A motif; other site 585035001017 ATP binding site [chemical binding]; other site 585035001018 Walker B motif; other site 585035001019 arginine finger; other site 585035001020 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585035001021 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 585035001022 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 585035001023 tetramer interface [polypeptide binding]; other site 585035001024 active site 585035001025 Mg2+/Mn2+ binding site [ion binding]; other site 585035001026 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 585035001027 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 585035001028 dimer interface [polypeptide binding]; other site 585035001029 active site 585035001030 citrylCoA binding site [chemical binding]; other site 585035001031 oxalacetate/citrate binding site [chemical binding]; other site 585035001032 coenzyme A binding site [chemical binding]; other site 585035001033 catalytic triad [active] 585035001034 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 585035001035 2-methylcitrate dehydratase; Region: prpD; TIGR02330 585035001036 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 585035001037 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 585035001038 acyl-activating enzyme (AAE) consensus motif; other site 585035001039 putative AMP binding site [chemical binding]; other site 585035001040 putative active site [active] 585035001041 putative CoA binding site [chemical binding]; other site 585035001042 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 585035001043 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 585035001044 Na binding site [ion binding]; other site 585035001045 putative substrate binding site [chemical binding]; other site 585035001046 cytosine deaminase; Provisional; Region: PRK09230 585035001047 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 585035001048 active site 585035001049 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 585035001050 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 585035001051 active site 585035001052 substrate binding site [chemical binding]; other site 585035001053 trimer interface [polypeptide binding]; other site 585035001054 CoA binding site [chemical binding]; other site 585035001055 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 585035001056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035001057 putative substrate translocation pore; other site 585035001058 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 585035001059 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 585035001060 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 585035001061 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 585035001062 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 585035001063 lac repressor; Reviewed; Region: lacI; PRK09526 585035001064 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585035001065 DNA binding site [nucleotide binding] 585035001066 domain linker motif; other site 585035001067 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 585035001068 ligand binding site [chemical binding]; other site 585035001069 dimerization interface (open form) [polypeptide binding]; other site 585035001070 dimerization interface (closed form) [polypeptide binding]; other site 585035001071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 585035001072 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 585035001073 S-formylglutathione hydrolase; Region: PLN02442 585035001074 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 585035001075 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 585035001076 substrate binding site [chemical binding]; other site 585035001077 catalytic Zn binding site [ion binding]; other site 585035001078 NAD binding site [chemical binding]; other site 585035001079 structural Zn binding site [ion binding]; other site 585035001080 dimer interface [polypeptide binding]; other site 585035001081 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 585035001082 putative metal binding site [ion binding]; other site 585035001083 putative homodimer interface [polypeptide binding]; other site 585035001084 putative homotetramer interface [polypeptide binding]; other site 585035001085 putative homodimer-homodimer interface [polypeptide binding]; other site 585035001086 putative allosteric switch controlling residues; other site 585035001087 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 585035001088 putative trimer interface [polypeptide binding]; other site 585035001089 putative CoA binding site [chemical binding]; other site 585035001090 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 585035001091 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 585035001092 DXD motif; other site 585035001093 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 585035001094 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 585035001095 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585035001096 substrate binding pocket [chemical binding]; other site 585035001097 membrane-bound complex binding site; other site 585035001098 hinge residues; other site 585035001099 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 585035001100 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 585035001101 Walker A/P-loop; other site 585035001102 ATP binding site [chemical binding]; other site 585035001103 Q-loop/lid; other site 585035001104 ABC transporter signature motif; other site 585035001105 Walker B; other site 585035001106 D-loop; other site 585035001107 H-loop/switch region; other site 585035001108 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 585035001109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035001110 dimer interface [polypeptide binding]; other site 585035001111 conserved gate region; other site 585035001112 putative PBP binding loops; other site 585035001113 ABC-ATPase subunit interface; other site 585035001114 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 585035001115 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 585035001116 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 585035001117 dimer interface [polypeptide binding]; other site 585035001118 active site 585035001119 Schiff base residues; other site 585035001120 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 585035001121 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 585035001122 Autotransporter beta-domain; Region: Autotransporter; pfam03797 585035001123 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 585035001124 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 585035001125 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 585035001126 microcin B17 transporter; Reviewed; Region: PRK11098 585035001127 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 585035001128 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 585035001129 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 585035001130 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 585035001131 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 585035001132 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 585035001133 anti-RssB factor; Provisional; Region: PRK10244 585035001134 alkaline phosphatase; Provisional; Region: PRK10518 585035001135 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 585035001136 dimer interface [polypeptide binding]; other site 585035001137 active site 585035001138 hypothetical protein; Provisional; Region: PRK11505 585035001139 psiF repeat; Region: PsiF_repeat; pfam07769 585035001140 psiF repeat; Region: PsiF_repeat; pfam07769 585035001141 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 585035001142 MASE2 domain; Region: MASE2; pfam05230 585035001143 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585035001144 metal binding site [ion binding]; metal-binding site 585035001145 active site 585035001146 I-site; other site 585035001147 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 585035001148 pyrroline-5-carboxylate reductase; Region: PLN02688 585035001149 hypothetical protein; Validated; Region: PRK00124 585035001150 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 585035001151 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 585035001152 ADP binding site [chemical binding]; other site 585035001153 magnesium binding site [ion binding]; other site 585035001154 putative shikimate binding site; other site 585035001155 hypothetical protein; Provisional; Region: PRK10380 585035001156 hypothetical protein; Provisional; Region: PRK10481 585035001157 hypothetical protein; Provisional; Region: PRK10579 585035001158 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 585035001159 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 585035001160 fructokinase; Reviewed; Region: PRK09557 585035001161 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585035001162 nucleotide binding site [chemical binding]; other site 585035001163 MFS transport protein AraJ; Provisional; Region: PRK10091 585035001164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035001165 putative substrate translocation pore; other site 585035001166 exonuclease subunit SbcC; Provisional; Region: PRK10246 585035001167 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585035001168 Walker A/P-loop; other site 585035001169 ATP binding site [chemical binding]; other site 585035001170 Q-loop/lid; other site 585035001171 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585035001172 ABC transporter signature motif; other site 585035001173 Walker B; other site 585035001174 D-loop; other site 585035001175 H-loop/switch region; other site 585035001176 exonuclease subunit SbcD; Provisional; Region: PRK10966 585035001177 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 585035001178 active site 585035001179 metal binding site [ion binding]; metal-binding site 585035001180 DNA binding site [nucleotide binding] 585035001181 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 585035001182 transcriptional regulator PhoB; Provisional; Region: PRK10161 585035001183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035001184 active site 585035001185 phosphorylation site [posttranslational modification] 585035001186 intermolecular recognition site; other site 585035001187 dimerization interface [polypeptide binding]; other site 585035001188 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585035001189 DNA binding site [nucleotide binding] 585035001190 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 585035001191 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 585035001192 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585035001193 putative active site [active] 585035001194 heme pocket [chemical binding]; other site 585035001195 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585035001196 dimer interface [polypeptide binding]; other site 585035001197 phosphorylation site [posttranslational modification] 585035001198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035001199 ATP binding site [chemical binding]; other site 585035001200 Mg2+ binding site [ion binding]; other site 585035001201 G-X-G motif; other site 585035001202 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 585035001203 putative proline-specific permease; Provisional; Region: proY; PRK10580 585035001204 Spore germination protein; Region: Spore_permease; cl17796 585035001205 maltodextrin glucosidase; Provisional; Region: PRK10785 585035001206 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 585035001207 homodimer interface [polypeptide binding]; other site 585035001208 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 585035001209 active site 585035001210 homodimer interface [polypeptide binding]; other site 585035001211 catalytic site [active] 585035001212 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 585035001213 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 585035001214 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 585035001215 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 585035001216 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 585035001217 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 585035001218 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 585035001219 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 585035001220 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 585035001221 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 585035001222 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 585035001223 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 585035001224 Protein export membrane protein; Region: SecD_SecF; pfam02355 585035001225 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 585035001226 active site 585035001227 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 585035001228 hypothetical protein; Provisional; Region: PRK11530 585035001229 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 585035001230 ATP cone domain; Region: ATP-cone; pfam03477 585035001231 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 585035001232 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 585035001233 catalytic motif [active] 585035001234 Zn binding site [ion binding]; other site 585035001235 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 585035001236 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 585035001237 homopentamer interface [polypeptide binding]; other site 585035001238 active site 585035001239 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 585035001240 putative RNA binding site [nucleotide binding]; other site 585035001241 thiamine monophosphate kinase; Provisional; Region: PRK05731 585035001242 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 585035001243 ATP binding site [chemical binding]; other site 585035001244 dimerization interface [polypeptide binding]; other site 585035001245 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 585035001246 tetramer interfaces [polypeptide binding]; other site 585035001247 binuclear metal-binding site [ion binding]; other site 585035001248 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585035001249 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585035001250 active site 585035001251 catalytic tetrad [active] 585035001252 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 585035001253 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 585035001254 TPP-binding site; other site 585035001255 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 585035001256 PYR/PP interface [polypeptide binding]; other site 585035001257 dimer interface [polypeptide binding]; other site 585035001258 TPP binding site [chemical binding]; other site 585035001259 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 585035001260 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 585035001261 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 585035001262 substrate binding pocket [chemical binding]; other site 585035001263 chain length determination region; other site 585035001264 substrate-Mg2+ binding site; other site 585035001265 catalytic residues [active] 585035001266 aspartate-rich region 1; other site 585035001267 active site lid residues [active] 585035001268 aspartate-rich region 2; other site 585035001269 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 585035001270 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 585035001271 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 585035001272 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 585035001273 Ligand Binding Site [chemical binding]; other site 585035001274 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 585035001275 active site residue [active] 585035001276 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 585035001277 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 585035001278 conserved cys residue [active] 585035001279 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 585035001280 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 585035001281 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 585035001282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 585035001283 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 585035001284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035001285 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585035001286 putative substrate translocation pore; other site 585035001287 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 585035001288 UbiA prenyltransferase family; Region: UbiA; pfam01040 585035001289 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 585035001290 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 585035001291 Subunit I/III interface [polypeptide binding]; other site 585035001292 Subunit III/IV interface [polypeptide binding]; other site 585035001293 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 585035001294 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 585035001295 D-pathway; other site 585035001296 Putative ubiquinol binding site [chemical binding]; other site 585035001297 Low-spin heme (heme b) binding site [chemical binding]; other site 585035001298 Putative water exit pathway; other site 585035001299 Binuclear center (heme o3/CuB) [ion binding]; other site 585035001300 K-pathway; other site 585035001301 Putative proton exit pathway; other site 585035001302 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 585035001303 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 585035001304 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 585035001305 muropeptide transporter; Reviewed; Region: ampG; PRK11902 585035001306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035001307 putative substrate translocation pore; other site 585035001308 hypothetical protein; Provisional; Region: PRK11627 585035001309 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 585035001310 transcriptional regulator BolA; Provisional; Region: PRK11628 585035001311 trigger factor; Provisional; Region: tig; PRK01490 585035001312 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 585035001313 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 585035001314 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 585035001315 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 585035001316 oligomer interface [polypeptide binding]; other site 585035001317 active site residues [active] 585035001318 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 585035001319 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 585035001320 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035001321 Walker A motif; other site 585035001322 ATP binding site [chemical binding]; other site 585035001323 Walker B motif; other site 585035001324 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 585035001325 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 585035001326 Found in ATP-dependent protease La (LON); Region: LON; smart00464 585035001327 Found in ATP-dependent protease La (LON); Region: LON; smart00464 585035001328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035001329 Walker A motif; other site 585035001330 ATP binding site [chemical binding]; other site 585035001331 Walker B motif; other site 585035001332 arginine finger; other site 585035001333 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 585035001334 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 585035001335 IHF dimer interface [polypeptide binding]; other site 585035001336 IHF - DNA interface [nucleotide binding]; other site 585035001337 periplasmic folding chaperone; Provisional; Region: PRK10788 585035001338 SurA N-terminal domain; Region: SurA_N_3; cl07813 585035001339 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 585035001340 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 585035001341 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 585035001342 active site 585035001343 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 585035001344 Ligand Binding Site [chemical binding]; other site 585035001345 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 585035001346 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 585035001347 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 585035001348 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 585035001349 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585035001350 active site 585035001351 motif I; other site 585035001352 motif II; other site 585035001353 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585035001354 dimerization interface [polypeptide binding]; other site 585035001355 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 585035001356 putative DNA binding site [nucleotide binding]; other site 585035001357 putative Zn2+ binding site [ion binding]; other site 585035001358 AsnC family; Region: AsnC_trans_reg; pfam01037 585035001359 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585035001360 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 585035001361 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585035001362 Walker A/P-loop; other site 585035001363 ATP binding site [chemical binding]; other site 585035001364 Q-loop/lid; other site 585035001365 ABC transporter signature motif; other site 585035001366 Walker B; other site 585035001367 D-loop; other site 585035001368 H-loop/switch region; other site 585035001369 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 585035001370 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585035001371 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 585035001372 Walker A/P-loop; other site 585035001373 ATP binding site [chemical binding]; other site 585035001374 Q-loop/lid; other site 585035001375 ABC transporter signature motif; other site 585035001376 Walker B; other site 585035001377 D-loop; other site 585035001378 H-loop/switch region; other site 585035001379 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 585035001380 Nitrogen regulatory protein P-II; Region: P-II; smart00938 585035001381 ammonium transporter; Provisional; Region: PRK10666 585035001382 acyl-CoA thioesterase II; Provisional; Region: PRK10526 585035001383 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 585035001384 active site 585035001385 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 585035001386 catalytic triad [active] 585035001387 dimer interface [polypeptide binding]; other site 585035001388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 585035001389 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 585035001390 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 585035001391 DNA binding site [nucleotide binding] 585035001392 active site 585035001393 Uncharacterized conserved protein [Function unknown]; Region: COG5507 585035001394 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 585035001395 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 585035001396 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585035001397 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 585035001398 maltose O-acetyltransferase; Provisional; Region: PRK10092 585035001399 Maltose acetyltransferase; Region: Mac; pfam12464 585035001400 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 585035001401 trimer interface [polypeptide binding]; other site 585035001402 active site 585035001403 substrate binding site [chemical binding]; other site 585035001404 CoA binding site [chemical binding]; other site 585035001405 gene expression modulator; Provisional; Region: PRK10945 585035001406 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 585035001407 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 585035001408 Protein export membrane protein; Region: SecD_SecF; cl14618 585035001409 Protein export membrane protein; Region: SecD_SecF; cl14618 585035001410 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 585035001411 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585035001412 HlyD family secretion protein; Region: HlyD_3; pfam13437 585035001413 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 585035001414 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585035001415 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 585035001416 hypothetical protein; Provisional; Region: PRK11281 585035001417 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 585035001418 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 585035001419 Mechanosensitive ion channel; Region: MS_channel; pfam00924 585035001420 hypothetical protein; Provisional; Region: PRK11038 585035001421 primosomal replication protein N''; Provisional; Region: PRK10093 585035001422 hypothetical protein; Provisional; Region: PRK10527 585035001423 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585035001424 active site 585035001425 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 585035001426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035001427 Walker A motif; other site 585035001428 ATP binding site [chemical binding]; other site 585035001429 Walker B motif; other site 585035001430 DNA polymerase III subunit delta'; Validated; Region: PRK08485 585035001431 arginine finger; other site 585035001432 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 585035001433 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 585035001434 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 585035001435 hypothetical protein; Validated; Region: PRK00153 585035001436 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 585035001437 RecR protein; Region: RecR; pfam02132 585035001438 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 585035001439 putative active site [active] 585035001440 putative metal-binding site [ion binding]; other site 585035001441 tetramer interface [polypeptide binding]; other site 585035001442 heat shock protein 90; Provisional; Region: PRK05218 585035001443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035001444 ATP binding site [chemical binding]; other site 585035001445 Mg2+ binding site [ion binding]; other site 585035001446 G-X-G motif; other site 585035001447 adenylate kinase; Reviewed; Region: adk; PRK00279 585035001448 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 585035001449 AMP-binding site [chemical binding]; other site 585035001450 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 585035001451 ferrochelatase; Region: hemH; TIGR00109 585035001452 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 585035001453 C-terminal domain interface [polypeptide binding]; other site 585035001454 active site 585035001455 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 585035001456 active site 585035001457 N-terminal domain interface [polypeptide binding]; other site 585035001458 acetyl esterase; Provisional; Region: PRK10162 585035001459 inosine/guanosine kinase; Provisional; Region: PRK15074 585035001460 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585035001461 putative cation:proton antiport protein; Provisional; Region: PRK10669 585035001462 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 585035001463 TrkA-N domain; Region: TrkA_N; pfam02254 585035001464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035001465 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585035001466 putative substrate translocation pore; other site 585035001467 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 585035001468 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 585035001469 active site 585035001470 metal binding site [ion binding]; metal-binding site 585035001471 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 585035001472 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 585035001473 putative deacylase active site [active] 585035001474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 585035001475 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 585035001476 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 585035001477 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585035001478 non-specific DNA binding site [nucleotide binding]; other site 585035001479 salt bridge; other site 585035001480 sequence-specific DNA binding site [nucleotide binding]; other site 585035001481 copper exporting ATPase; Provisional; Region: copA; PRK10671 585035001482 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 585035001483 metal-binding site [ion binding] 585035001484 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 585035001485 metal-binding site [ion binding] 585035001486 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 585035001487 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585035001488 motif II; other site 585035001489 glutaminase; Reviewed; Region: PRK12356 585035001490 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 585035001491 amino acid transporter; Region: 2A0306; TIGR00909 585035001492 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 585035001493 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 585035001494 DNA binding residues [nucleotide binding] 585035001495 dimer interface [polypeptide binding]; other site 585035001496 copper binding site [ion binding]; other site 585035001497 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 585035001498 YadA-like C-terminal region; Region: YadA; pfam03895 585035001499 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 585035001500 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 585035001501 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 585035001502 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 585035001503 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585035001504 Walker A/P-loop; other site 585035001505 ATP binding site [chemical binding]; other site 585035001506 Q-loop/lid; other site 585035001507 ABC transporter signature motif; other site 585035001508 Walker B; other site 585035001509 D-loop; other site 585035001510 H-loop/switch region; other site 585035001511 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 585035001512 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 585035001513 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 585035001514 oxidoreductase; Provisional; Region: PRK08017 585035001515 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 585035001516 NADP binding site [chemical binding]; other site 585035001517 active site 585035001518 steroid binding site; other site 585035001519 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 585035001520 active site 585035001521 catalytic triad [active] 585035001522 oxyanion hole [active] 585035001523 switch loop; other site 585035001524 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 585035001525 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 585035001526 Walker A/P-loop; other site 585035001527 ATP binding site [chemical binding]; other site 585035001528 Q-loop/lid; other site 585035001529 ABC transporter signature motif; other site 585035001530 Walker B; other site 585035001531 D-loop; other site 585035001532 H-loop/switch region; other site 585035001533 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 585035001534 FtsX-like permease family; Region: FtsX; pfam02687 585035001535 FtsX-like permease family; Region: FtsX; pfam02687 585035001536 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 585035001537 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 585035001538 active site residue [active] 585035001539 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 585035001540 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035001541 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585035001542 dimerization interface [polypeptide binding]; other site 585035001543 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 585035001544 ureidoglycolate hydrolase; Provisional; Region: PRK03606 585035001545 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 585035001546 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 585035001547 Bacterial transcriptional regulator; Region: IclR; pfam01614 585035001548 glyoxylate carboligase; Provisional; Region: PRK11269 585035001549 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 585035001550 PYR/PP interface [polypeptide binding]; other site 585035001551 dimer interface [polypeptide binding]; other site 585035001552 TPP binding site [chemical binding]; other site 585035001553 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 585035001554 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 585035001555 TPP-binding site [chemical binding]; other site 585035001556 hydroxypyruvate isomerase; Provisional; Region: PRK09997 585035001557 tartronate semialdehyde reductase; Provisional; Region: PRK15059 585035001558 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 585035001559 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 585035001560 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 585035001561 Na binding site [ion binding]; other site 585035001562 substrate binding site [chemical binding]; other site 585035001563 allantoinase; Provisional; Region: PRK08044 585035001564 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 585035001565 active site 585035001566 putative uracil/xanthine transporter; Provisional; Region: PRK11412 585035001567 glycerate kinase II; Provisional; Region: PRK09932 585035001568 putative allantoin catabolism protein; Region: ura-cupin; TIGR03214 585035001569 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 585035001570 Cupin domain; Region: Cupin_2; cl17218 585035001571 allantoate amidohydrolase; Region: AllC; TIGR03176 585035001572 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 585035001573 active site 585035001574 metal binding site [ion binding]; metal-binding site 585035001575 dimer interface [polypeptide binding]; other site 585035001576 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 585035001577 membrane protein FdrA; Validated; Region: PRK06091 585035001578 CoA binding domain; Region: CoA_binding; pfam02629 585035001579 CoA-ligase; Region: Ligase_CoA; pfam00549 585035001580 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 585035001581 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 585035001582 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 585035001583 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 585035001584 putative substrate binding site [chemical binding]; other site 585035001585 nucleotide binding site [chemical binding]; other site 585035001586 nucleotide binding site [chemical binding]; other site 585035001587 homodimer interface [polypeptide binding]; other site 585035001588 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 585035001589 ATP-grasp domain; Region: ATP-grasp; pfam02222 585035001590 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 585035001591 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 585035001592 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 585035001593 putative active site [active] 585035001594 putative metal binding site [ion binding]; other site 585035001595 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 585035001596 substrate binding site [chemical binding]; other site 585035001597 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 585035001598 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 585035001599 active site 585035001600 HIGH motif; other site 585035001601 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 585035001602 KMSKS motif; other site 585035001603 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 585035001604 tRNA binding surface [nucleotide binding]; other site 585035001605 anticodon binding site; other site 585035001606 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 585035001607 ribosome-associated protein; Provisional; Region: PRK11507 585035001608 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 585035001609 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 585035001610 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 585035001611 homodimer interface [polypeptide binding]; other site 585035001612 NADP binding site [chemical binding]; other site 585035001613 substrate binding site [chemical binding]; other site 585035001614 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 585035001615 Int/Topo IB signature motif; other site 585035001616 Helix-turn-helix domain; Region: HTH_17; pfam12728 585035001617 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 585035001618 Uncharacterized conserved protein [Function unknown]; Region: COG5532 585035001619 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 585035001620 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585035001621 non-specific DNA binding site [nucleotide binding]; other site 585035001622 salt bridge; other site 585035001623 sequence-specific DNA binding site [nucleotide binding]; other site 585035001624 Predicted transcriptional regulator [Transcription]; Region: COG2932 585035001625 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585035001626 Catalytic site [active] 585035001627 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585035001628 non-specific DNA binding site [nucleotide binding]; other site 585035001629 salt bridge; other site 585035001630 sequence-specific DNA binding site [nucleotide binding]; other site 585035001631 Ash protein family; Region: Phage_ASH; pfam10554 585035001632 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 585035001633 Ash protein family; Region: Phage_ASH; pfam10554 585035001634 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 585035001635 Helix-turn-helix domain; Region: HTH_36; pfam13730 585035001636 PerC transcriptional activator; Region: PerC; pfam06069 585035001637 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 585035001638 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 585035001639 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 585035001640 KilA-N domain; Region: KilA-N; pfam04383 585035001641 Protein of unknown function (DUF968); Region: DUF968; pfam06147 585035001642 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 585035001643 WYL domain; Region: WYL; cl14852 585035001644 transcriptional regulator YdeO; Provisional; Region: PRK09940 585035001645 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035001646 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 585035001647 Domain of unknown function (DUF303); Region: DUF303; pfam03629 585035001648 Protein of unknown function (DUF1378); Region: DUF1378; pfam07125 585035001649 Protein of unknown function (DUF826); Region: DUF826; pfam05696 585035001650 Lysis protein S; Region: Lysis_S; pfam04971 585035001651 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 585035001652 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585035001653 catalytic residues [active] 585035001654 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585035001655 KilA-N domain; Region: KilA-N; pfam04383 585035001656 ORF11CD3 domain; Region: ORF11CD3; pfam10549 585035001657 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 585035001658 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 585035001659 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 585035001660 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 585035001661 gpW; Region: gpW; pfam02831 585035001662 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 585035001663 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 585035001664 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 585035001665 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 585035001666 tandem repeat interface [polypeptide binding]; other site 585035001667 oligomer interface [polypeptide binding]; other site 585035001668 active site residues [active] 585035001669 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 585035001670 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 585035001671 DNA packaging protein FI; Region: Packaging_FI; pfam14000 585035001672 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 585035001673 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 585035001674 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 585035001675 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 585035001676 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 585035001677 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 585035001678 Minor tail protein T; Region: Phage_tail_T; pfam06223 585035001679 Phage-related minor tail protein [Function unknown]; Region: COG5281 585035001680 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 585035001681 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 585035001682 Phage-related protein [Function unknown]; Region: COG4718 585035001683 Phage-related protein [Function unknown]; Region: gp18; COG4672 585035001684 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 585035001685 MPN+ (JAMM) motif; other site 585035001686 Zinc-binding site [ion binding]; other site 585035001687 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585035001688 NlpC/P60 family; Region: NLPC_P60; cl17555 585035001689 Phage-related protein, tail component [Function unknown]; Region: COG4723 585035001690 Phage-related protein, tail component [Function unknown]; Region: COG4733 585035001691 Putative phage tail protein; Region: Phage-tail_3; pfam13550 585035001692 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 585035001693 Interdomain contacts; other site 585035001694 Cytokine receptor motif; other site 585035001695 Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811 585035001696 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 585035001697 Fibronectin type III protein; Region: DUF3672; pfam12421 585035001698 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 585035001699 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 585035001700 Methyltransferase domain; Region: Methyltransf_12; pfam08242 585035001701 S-adenosylmethionine binding site [chemical binding]; other site 585035001702 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 585035001703 TAP-like protein; Region: Abhydrolase_4; pfam08386 585035001704 outer membrane protease; Reviewed; Region: PRK10993 585035001705 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin 585035001706 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin 585035001707 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 585035001708 Methyltransferase domain; Region: Methyltransf_12; pfam08242 585035001709 S-adenosylmethionine binding site [chemical binding]; other site 585035001710 outer membrane protease; Reviewed; Region: PRK10993 585035001711 hypothetical protein; Provisional; Region: PRK09936 585035001712 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 585035001713 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585035001714 TPR motif; other site 585035001715 binding surface 585035001716 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 585035001717 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 585035001718 active site 585035001719 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 585035001720 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 585035001721 sensor kinase CusS; Provisional; Region: PRK09835 585035001722 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585035001723 dimerization interface [polypeptide binding]; other site 585035001724 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585035001725 dimer interface [polypeptide binding]; other site 585035001726 phosphorylation site [posttranslational modification] 585035001727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035001728 ATP binding site [chemical binding]; other site 585035001729 Mg2+ binding site [ion binding]; other site 585035001730 G-X-G motif; other site 585035001731 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 585035001732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035001733 active site 585035001734 phosphorylation site [posttranslational modification] 585035001735 intermolecular recognition site; other site 585035001736 dimerization interface [polypeptide binding]; other site 585035001737 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585035001738 DNA binding site [nucleotide binding] 585035001739 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 585035001740 periplasmic copper-binding protein; Provisional; Region: PRK09838 585035001741 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 585035001742 HlyD family secretion protein; Region: HlyD_3; pfam13437 585035001743 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 585035001744 phenylalanine transporter; Provisional; Region: PRK10249 585035001745 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 585035001746 Mechanosensitive ion channel; Region: MS_channel; pfam00924 585035001747 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 585035001748 dimer interface [polypeptide binding]; other site 585035001749 FMN binding site [chemical binding]; other site 585035001750 hypothetical protein; Provisional; Region: PRK10250 585035001751 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 585035001752 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 585035001753 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 585035001754 Hok/gef family; Region: HOK_GEF; pfam01848 585035001755 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 585035001756 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 585035001757 outer membrane receptor FepA; Provisional; Region: PRK13524 585035001758 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585035001759 N-terminal plug; other site 585035001760 ligand-binding site [chemical binding]; other site 585035001761 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 585035001762 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 585035001763 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 585035001764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 585035001765 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 585035001766 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 585035001767 acyl-activating enzyme (AAE) consensus motif; other site 585035001768 AMP binding site [chemical binding]; other site 585035001769 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 585035001770 LPS O-antigen length regulator; Provisional; Region: PRK10381 585035001771 Chain length determinant protein; Region: Wzz; pfam02706 585035001772 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 585035001773 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 585035001774 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 585035001775 Walker A/P-loop; other site 585035001776 ATP binding site [chemical binding]; other site 585035001777 Q-loop/lid; other site 585035001778 ABC transporter signature motif; other site 585035001779 Walker B; other site 585035001780 D-loop; other site 585035001781 H-loop/switch region; other site 585035001782 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 585035001783 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585035001784 ABC-ATPase subunit interface; other site 585035001785 dimer interface [polypeptide binding]; other site 585035001786 putative PBP binding regions; other site 585035001787 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 585035001788 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585035001789 ABC-ATPase subunit interface; other site 585035001790 dimer interface [polypeptide binding]; other site 585035001791 putative PBP binding regions; other site 585035001792 enterobactin exporter EntS; Provisional; Region: PRK10489 585035001793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035001794 putative substrate translocation pore; other site 585035001795 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 585035001796 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 585035001797 siderophore binding site; other site 585035001798 isochorismate synthase EntC; Provisional; Region: PRK15016 585035001799 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 585035001800 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 585035001801 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 585035001802 acyl-activating enzyme (AAE) consensus motif; other site 585035001803 active site 585035001804 AMP binding site [chemical binding]; other site 585035001805 substrate binding site [chemical binding]; other site 585035001806 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 585035001807 hydrophobic substrate binding pocket; other site 585035001808 Isochorismatase family; Region: Isochorismatase; pfam00857 585035001809 active site 585035001810 conserved cis-peptide bond; other site 585035001811 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 585035001812 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 585035001813 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 585035001814 putative NAD(P) binding site [chemical binding]; other site 585035001815 active site 585035001816 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 585035001817 CoenzymeA binding site [chemical binding]; other site 585035001818 subunit interaction site [polypeptide binding]; other site 585035001819 PHB binding site; other site 585035001820 carbon starvation protein A; Provisional; Region: PRK15015 585035001821 Carbon starvation protein CstA; Region: CstA; pfam02554 585035001822 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 585035001823 Uncharacterized small protein [Function unknown]; Region: COG2879 585035001824 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 585035001825 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 585035001826 putative active site [active] 585035001827 metal binding site [ion binding]; metal-binding site 585035001828 Evidence 7 : Gene remnant; Product type e : enzyme 585035001829 Evidence 7 : Gene remnant; Product type e : enzyme 585035001830 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 585035001831 ParB-like nuclease domain; Region: ParBc; pfam02195 585035001832 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 585035001833 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 585035001834 Active Sites [active] 585035001835 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 585035001836 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 585035001837 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035001838 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585035001839 dimerization interface [polypeptide binding]; other site 585035001840 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 585035001841 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 585035001842 dimerization domain [polypeptide binding]; other site 585035001843 dimer interface [polypeptide binding]; other site 585035001844 catalytic residues [active] 585035001845 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 585035001846 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 585035001847 dimer interface [polypeptide binding]; other site 585035001848 decamer (pentamer of dimers) interface [polypeptide binding]; other site 585035001849 catalytic triad [active] 585035001850 peroxidatic and resolving cysteines [active] 585035001851 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 585035001852 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 585035001853 catalytic residue [active] 585035001854 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 585035001855 catalytic residues [active] 585035001856 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585035001857 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585035001858 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585035001859 Ligand Binding Site [chemical binding]; other site 585035001860 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 585035001861 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 585035001862 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 585035001863 B1 nucleotide binding pocket [chemical binding]; other site 585035001864 B2 nucleotide binding pocket [chemical binding]; other site 585035001865 CAS motifs; other site 585035001866 active site 585035001867 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 585035001868 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 585035001869 transmembrane helices; other site 585035001870 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 585035001871 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 585035001872 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 585035001873 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 585035001874 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 585035001875 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 585035001876 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 585035001877 putative active site [active] 585035001878 (T/H)XGH motif; other site 585035001879 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 585035001880 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585035001881 putative active site [active] 585035001882 heme pocket [chemical binding]; other site 585035001883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035001884 ATP binding site [chemical binding]; other site 585035001885 Mg2+ binding site [ion binding]; other site 585035001886 G-X-G motif; other site 585035001887 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 585035001888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035001889 active site 585035001890 phosphorylation site [posttranslational modification] 585035001891 intermolecular recognition site; other site 585035001892 dimerization interface [polypeptide binding]; other site 585035001893 Transcriptional regulator; Region: CitT; pfam12431 585035001894 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 585035001895 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 585035001896 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 585035001897 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585035001898 DNA-binding site [nucleotide binding]; DNA binding site 585035001899 RNA-binding motif; other site 585035001900 chromosome condensation membrane protein; Provisional; Region: PRK14196 585035001901 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 585035001902 Predicted amidohydrolase [General function prediction only]; Region: COG0388 585035001903 active site 585035001904 catalytic triad [active] 585035001905 dimer interface [polypeptide binding]; other site 585035001906 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 585035001907 lipoyl synthase; Provisional; Region: PRK05481 585035001908 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585035001909 FeS/SAM binding site; other site 585035001910 Evidence 7 : Gene remnant; Product type pr : regulator 585035001911 lipoate-protein ligase B; Provisional; Region: PRK14342 585035001912 hypothetical protein; Provisional; Region: PRK04998 585035001913 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 585035001914 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 585035001915 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 585035001916 rare lipoprotein A; Provisional; Region: PRK10672 585035001917 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 585035001918 Sporulation related domain; Region: SPOR; pfam05036 585035001919 cell wall shape-determining protein; Provisional; Region: PRK10794 585035001920 penicillin-binding protein 2; Provisional; Region: PRK10795 585035001921 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 585035001922 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 585035001923 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 585035001924 ribosome-associated protein; Provisional; Region: PRK11538 585035001925 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 585035001926 catalytic core [active] 585035001927 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 585035001928 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 585035001929 active site 585035001930 (T/H)XGH motif; other site 585035001931 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 585035001932 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 585035001933 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 585035001934 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 585035001935 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 585035001936 HIGH motif; other site 585035001937 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 585035001938 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 585035001939 active site 585035001940 KMSKS motif; other site 585035001941 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 585035001942 tRNA binding surface [nucleotide binding]; other site 585035001943 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 585035001944 hypothetical protein; Provisional; Region: PRK11032 585035001945 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 585035001946 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 585035001947 active site 585035001948 tetramer interface [polypeptide binding]; other site 585035001949 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 585035001950 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 585035001951 Walker A/P-loop; other site 585035001952 ATP binding site [chemical binding]; other site 585035001953 Q-loop/lid; other site 585035001954 ABC transporter signature motif; other site 585035001955 Walker B; other site 585035001956 D-loop; other site 585035001957 H-loop/switch region; other site 585035001958 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585035001959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035001960 dimer interface [polypeptide binding]; other site 585035001961 conserved gate region; other site 585035001962 putative PBP binding loops; other site 585035001963 ABC-ATPase subunit interface; other site 585035001964 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585035001965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035001966 dimer interface [polypeptide binding]; other site 585035001967 conserved gate region; other site 585035001968 putative PBP binding loops; other site 585035001969 ABC-ATPase subunit interface; other site 585035001970 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 585035001971 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585035001972 substrate binding pocket [chemical binding]; other site 585035001973 membrane-bound complex binding site; other site 585035001974 hinge residues; other site 585035001975 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 585035001976 Uncharacterized conserved protein [Function unknown]; Region: COG3391 585035001977 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 585035001978 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 585035001979 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 585035001980 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 585035001981 putative active site [active] 585035001982 catalytic triad [active] 585035001983 putative dimer interface [polypeptide binding]; other site 585035001984 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 585035001985 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 585035001986 Transporter associated domain; Region: CorC_HlyC; smart01091 585035001987 metal-binding heat shock protein; Provisional; Region: PRK00016 585035001988 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 585035001989 PhoH-like protein; Region: PhoH; pfam02562 585035001990 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 585035001991 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 585035001992 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585035001993 FeS/SAM binding site; other site 585035001994 TRAM domain; Region: TRAM; pfam01938 585035001995 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 585035001996 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 585035001997 similar to hypothetical protein; Evidence 6 : Doubtful CDS 585035001998 asparagine synthetase B; Provisional; Region: asnB; PRK09431 585035001999 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 585035002000 active site 585035002001 dimer interface [polypeptide binding]; other site 585035002002 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 585035002003 Ligand Binding Site [chemical binding]; other site 585035002004 Molecular Tunnel; other site 585035002005 UMP phosphatase; Provisional; Region: PRK10444 585035002006 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585035002007 active site 585035002008 motif I; other site 585035002009 motif II; other site 585035002010 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585035002011 MarR family; Region: MarR; pfam01047 585035002012 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 585035002013 ROK family; Region: ROK; pfam00480 585035002014 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 585035002015 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 585035002016 active site 585035002017 dimer interface [polypeptide binding]; other site 585035002018 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 585035002019 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 585035002020 active site 585035002021 trimer interface [polypeptide binding]; other site 585035002022 allosteric site; other site 585035002023 active site lid [active] 585035002024 hexamer (dimer of trimers) interface [polypeptide binding]; other site 585035002025 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 585035002026 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 585035002027 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585035002028 active site turn [active] 585035002029 phosphorylation site [posttranslational modification] 585035002030 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 585035002031 HPr interaction site; other site 585035002032 glycerol kinase (GK) interaction site [polypeptide binding]; other site 585035002033 active site 585035002034 phosphorylation site [posttranslational modification] 585035002035 Evidence 4 : Homologs of previously reported genes of unknown function 585035002036 Evidence 4 : Homologs of previously reported genes of unknown function 585035002037 Domain of unknown function (DUF386); Region: DUF386; cl01047 585035002038 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 585035002039 BNR repeat-like domain; Region: BNR_2; pfam13088 585035002040 Evidence 7 : Gene remnant; Product type pm : membrane component 585035002041 Evidence 7 : Gene remnant; Product type pm : membrane component 585035002042 dihydrodipicolinate synthase; Region: dapA; TIGR00674 585035002043 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 585035002044 inhibitor site; inhibition site 585035002045 active site 585035002046 dimer interface [polypeptide binding]; other site 585035002047 catalytic residue [active] 585035002048 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 585035002049 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 585035002050 putative active site [active] 585035002051 metal binding site [ion binding]; metal-binding site 585035002052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 585035002053 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 585035002054 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 585035002055 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 585035002056 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 585035002057 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585035002058 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 585035002059 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 585035002060 active site 585035002061 HIGH motif; other site 585035002062 nucleotide binding site [chemical binding]; other site 585035002063 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 585035002064 KMSKS motif; other site 585035002065 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 585035002066 outer membrane porin, OprD family; Region: OprD; pfam03573 585035002067 YbfN-like lipoprotein; Region: YbfN; pfam13982 585035002068 ferric uptake regulator; Provisional; Region: fur; PRK09462 585035002069 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 585035002070 metal binding site 2 [ion binding]; metal-binding site 585035002071 putative DNA binding helix; other site 585035002072 metal binding site 1 [ion binding]; metal-binding site 585035002073 dimer interface [polypeptide binding]; other site 585035002074 structural Zn2+ binding site [ion binding]; other site 585035002075 flavodoxin FldA; Validated; Region: PRK09267 585035002076 LexA regulated protein; Provisional; Region: PRK11675 585035002077 acyl-CoA esterase; Provisional; Region: PRK10673 585035002078 PGAP1-like protein; Region: PGAP1; pfam07819 585035002079 replication initiation regulator SeqA; Provisional; Region: PRK11187 585035002080 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 585035002081 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 585035002082 active site 585035002083 substrate binding site [chemical binding]; other site 585035002084 metal binding site [ion binding]; metal-binding site 585035002085 putrescine transporter; Provisional; Region: potE; PRK10655 585035002086 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 585035002087 ornithine decarboxylase; Provisional; Region: PRK13578 585035002088 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 585035002089 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 585035002090 homodimer interface [polypeptide binding]; other site 585035002091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035002092 catalytic residue [active] 585035002093 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 585035002094 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 585035002095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035002096 active site 585035002097 phosphorylation site [posttranslational modification] 585035002098 intermolecular recognition site; other site 585035002099 dimerization interface [polypeptide binding]; other site 585035002100 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585035002101 DNA binding site [nucleotide binding] 585035002102 sensor protein KdpD; Provisional; Region: PRK10490 585035002103 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 585035002104 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 585035002105 Ligand Binding Site [chemical binding]; other site 585035002106 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 585035002107 GAF domain; Region: GAF_3; pfam13492 585035002108 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585035002109 dimer interface [polypeptide binding]; other site 585035002110 phosphorylation site [posttranslational modification] 585035002111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035002112 ATP binding site [chemical binding]; other site 585035002113 Mg2+ binding site [ion binding]; other site 585035002114 G-X-G motif; other site 585035002115 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 585035002116 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 585035002117 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 585035002118 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 585035002119 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 585035002120 hypothetical protein; Provisional; Region: PRK10167 585035002121 Uncharacterized conserved protein [Function unknown]; Region: COG3272 585035002122 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 585035002123 DNA photolyase; Region: DNA_photolyase; pfam00875 585035002124 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 585035002125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035002126 putative substrate translocation pore; other site 585035002127 POT family; Region: PTR2; pfam00854 585035002128 Uncharacterized conserved protein [Function unknown]; Region: COG0327 585035002129 metal-binding protein; Provisional; Region: PRK10799 585035002130 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 585035002131 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 585035002132 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 585035002133 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 585035002134 putative active site [active] 585035002135 endonuclease VIII; Provisional; Region: PRK10445 585035002136 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 585035002137 DNA binding site [nucleotide binding] 585035002138 catalytic residue [active] 585035002139 putative catalytic residues [active] 585035002140 H2TH interface [polypeptide binding]; other site 585035002141 intercalation triad [nucleotide binding]; other site 585035002142 substrate specificity determining residue; other site 585035002143 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 585035002144 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 585035002145 Putative ammonia monooxygenase; Region: AmoA; pfam05145 585035002146 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 585035002147 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 585035002148 Evidence 7 : Gene remnant 585035002149 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 585035002150 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 585035002151 dimer interface [polypeptide binding]; other site 585035002152 active site 585035002153 citrylCoA binding site [chemical binding]; other site 585035002154 NADH binding [chemical binding]; other site 585035002155 cationic pore residues; other site 585035002156 oxalacetate/citrate binding site [chemical binding]; other site 585035002157 coenzyme A binding site [chemical binding]; other site 585035002158 catalytic triad [active] 585035002159 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 585035002160 Iron-sulfur protein interface; other site 585035002161 proximal quinone binding site [chemical binding]; other site 585035002162 SdhD (CybS) interface [polypeptide binding]; other site 585035002163 proximal heme binding site [chemical binding]; other site 585035002164 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 585035002165 SdhC subunit interface [polypeptide binding]; other site 585035002166 proximal heme binding site [chemical binding]; other site 585035002167 cardiolipin binding site; other site 585035002168 Iron-sulfur protein interface; other site 585035002169 proximal quinone binding site [chemical binding]; other site 585035002170 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 585035002171 L-aspartate oxidase; Provisional; Region: PRK06175 585035002172 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 585035002173 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 585035002174 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 585035002175 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 585035002176 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 585035002177 TPP-binding site [chemical binding]; other site 585035002178 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 585035002179 dimer interface [polypeptide binding]; other site 585035002180 PYR/PP interface [polypeptide binding]; other site 585035002181 TPP binding site [chemical binding]; other site 585035002182 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 585035002183 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 585035002184 E3 interaction surface; other site 585035002185 lipoyl attachment site [posttranslational modification]; other site 585035002186 e3 binding domain; Region: E3_binding; pfam02817 585035002187 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 585035002188 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 585035002189 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 585035002190 CoA-ligase; Region: Ligase_CoA; pfam00549 585035002191 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 585035002192 CoA binding domain; Region: CoA_binding; smart00881 585035002193 CoA-ligase; Region: Ligase_CoA; pfam00549 585035002194 TPR repeat; Region: TPR_11; pfam13414 585035002195 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585035002196 binding surface 585035002197 TPR motif; other site 585035002198 Tetratricopeptide repeat; Region: TPR_12; pfam13424 585035002199 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 585035002200 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 585035002201 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 585035002202 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 585035002203 hypothetical protein; Provisional; Region: PRK10588 585035002204 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 585035002205 active site 585035002206 colicin uptake protein TolQ; Provisional; Region: PRK10801 585035002207 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 585035002208 colicin uptake protein TolR; Provisional; Region: PRK11024 585035002209 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 585035002210 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 585035002211 TolA C-terminal; Region: TolA; pfam06519 585035002212 translocation protein TolB; Provisional; Region: tolB; PRK03629 585035002213 TolB amino-terminal domain; Region: TolB_N; pfam04052 585035002214 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 585035002215 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 585035002216 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 585035002217 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 585035002218 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585035002219 ligand binding site [chemical binding]; other site 585035002220 tol-pal system protein YbgF; Provisional; Region: PRK10803 585035002221 Tetratricopeptide repeat; Region: TPR_6; pfam13174 585035002222 Tetratricopeptide repeat; Region: TPR_6; pfam13174 585035002223 quinolinate synthetase; Provisional; Region: PRK09375 585035002224 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 585035002225 zinc transporter ZitB; Provisional; Region: PRK03557 585035002226 YbgS-like protein; Region: YbgS; pfam13985 585035002227 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 585035002228 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 585035002229 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 585035002230 catalytic core [active] 585035002231 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 585035002232 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 585035002233 active site 585035002234 catalytic residues [active] 585035002235 galactokinase; Provisional; Region: PRK05101 585035002236 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 585035002237 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 585035002238 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 585035002239 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 585035002240 dimer interface [polypeptide binding]; other site 585035002241 active site 585035002242 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 585035002243 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 585035002244 NAD binding site [chemical binding]; other site 585035002245 homodimer interface [polypeptide binding]; other site 585035002246 active site 585035002247 substrate binding site [chemical binding]; other site 585035002248 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 585035002249 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 585035002250 Walker A/P-loop; other site 585035002251 ATP binding site [chemical binding]; other site 585035002252 Q-loop/lid; other site 585035002253 ABC transporter signature motif; other site 585035002254 Walker B; other site 585035002255 D-loop; other site 585035002256 H-loop/switch region; other site 585035002257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585035002258 Walker A/P-loop; other site 585035002259 ATP binding site [chemical binding]; other site 585035002260 Q-loop/lid; other site 585035002261 ABC transporter signature motif; other site 585035002262 Walker B; other site 585035002263 D-loop; other site 585035002264 H-loop/switch region; other site 585035002265 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 585035002266 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 585035002267 molybdenum-pterin binding domain; Region: Mop; TIGR00638 585035002268 TOBE domain; Region: TOBE; pfam03459 585035002269 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 585035002270 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 585035002271 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585035002272 substrate binding pocket [chemical binding]; other site 585035002273 membrane-bound complex binding site; other site 585035002274 hinge residues; other site 585035002275 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 585035002276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035002277 dimer interface [polypeptide binding]; other site 585035002278 conserved gate region; other site 585035002279 putative PBP binding loops; other site 585035002280 ABC-ATPase subunit interface; other site 585035002281 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 585035002282 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585035002283 Walker A/P-loop; other site 585035002284 ATP binding site [chemical binding]; other site 585035002285 Q-loop/lid; other site 585035002286 ABC transporter signature motif; other site 585035002287 Walker B; other site 585035002288 D-loop; other site 585035002289 H-loop/switch region; other site 585035002290 molybdenum-pterin binding domain; Region: Mop; TIGR00638 585035002291 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 585035002292 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585035002293 motif II; other site 585035002294 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585035002295 6-phosphogluconolactonase; Provisional; Region: PRK11028 585035002296 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585035002297 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035002298 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 585035002299 putative dimerization interface [polypeptide binding]; other site 585035002300 PrpF protein; Region: PrpF; pfam04303 585035002301 Evidence 7 : Gene remnant; Product type pt : transporter 585035002302 Evidence 7 : Gene remnant; Product type pt : transporter 585035002303 putative hydratase; Provisional; Region: PRK11413 585035002304 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 585035002305 substrate binding site [chemical binding]; other site 585035002306 ligand binding site [chemical binding]; other site 585035002307 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 585035002308 substrate binding site [chemical binding]; other site 585035002309 acyl-CoA thioesterase; Provisional; Region: PRK10531 585035002310 putative pectinesterase; Region: PLN02432; cl01911 585035002311 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 585035002312 substrate binding site [chemical binding]; other site 585035002313 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 585035002314 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585035002315 inhibitor-cofactor binding pocket; inhibition site 585035002316 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035002317 catalytic residue [active] 585035002318 biotin synthase; Provisional; Region: PRK15108 585035002319 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585035002320 FeS/SAM binding site; other site 585035002321 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 585035002322 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 585035002323 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 585035002324 substrate-cofactor binding pocket; other site 585035002325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035002326 catalytic residue [active] 585035002327 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 585035002328 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035002329 S-adenosylmethionine binding site [chemical binding]; other site 585035002330 AAA domain; Region: AAA_26; pfam13500 585035002331 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 585035002332 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 585035002333 ADP binding site [chemical binding]; other site 585035002334 excinuclease ABC subunit B; Provisional; Region: PRK05298 585035002335 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585035002336 ATP binding site [chemical binding]; other site 585035002337 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585035002338 nucleotide binding region [chemical binding]; other site 585035002339 ATP-binding site [chemical binding]; other site 585035002340 Ultra-violet resistance protein B; Region: UvrB; pfam12344 585035002341 UvrB/uvrC motif; Region: UVR; pfam02151 585035002342 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 585035002343 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 585035002344 putative substrate binding pocket [chemical binding]; other site 585035002345 dimer interface [polypeptide binding]; other site 585035002346 phosphate binding site [ion binding]; other site 585035002347 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 585035002348 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585035002349 FeS/SAM binding site; other site 585035002350 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 585035002351 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 585035002352 MPT binding site; other site 585035002353 trimer interface [polypeptide binding]; other site 585035002354 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 585035002355 trimer interface [polypeptide binding]; other site 585035002356 dimer interface [polypeptide binding]; other site 585035002357 putative active site [active] 585035002358 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 585035002359 MoaE interaction surface [polypeptide binding]; other site 585035002360 MoeB interaction surface [polypeptide binding]; other site 585035002361 thiocarboxylated glycine; other site 585035002362 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 585035002363 MoaE homodimer interface [polypeptide binding]; other site 585035002364 MoaD interaction [polypeptide binding]; other site 585035002365 active site residues [active] 585035002366 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 585035002367 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 585035002368 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 585035002369 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 585035002370 Predicted integral membrane protein [Function unknown]; Region: COG0392 585035002371 cardiolipin synthase 2; Provisional; Region: PRK11263 585035002372 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 585035002373 putative active site [active] 585035002374 catalytic site [active] 585035002375 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 585035002376 putative active site [active] 585035002377 catalytic site [active] 585035002378 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 585035002379 putative catalytic site [active] 585035002380 putative metal binding site [ion binding]; other site 585035002381 putative phosphate binding site [ion binding]; other site 585035002382 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 585035002383 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 585035002384 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 585035002385 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 585035002386 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 585035002387 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 585035002388 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 585035002389 Walker A/P-loop; other site 585035002390 ATP binding site [chemical binding]; other site 585035002391 Q-loop/lid; other site 585035002392 ABC transporter signature motif; other site 585035002393 Walker B; other site 585035002394 D-loop; other site 585035002395 H-loop/switch region; other site 585035002396 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 585035002397 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 585035002398 Walker A/P-loop; other site 585035002399 ATP binding site [chemical binding]; other site 585035002400 Q-loop/lid; other site 585035002401 ABC transporter signature motif; other site 585035002402 Walker B; other site 585035002403 D-loop; other site 585035002404 H-loop/switch region; other site 585035002405 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 585035002406 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585035002407 HlyD family secretion protein; Region: HlyD_3; pfam13437 585035002408 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 585035002409 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 585035002410 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 585035002411 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 585035002412 ATP binding site [chemical binding]; other site 585035002413 Mg++ binding site [ion binding]; other site 585035002414 motif III; other site 585035002415 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585035002416 nucleotide binding region [chemical binding]; other site 585035002417 ATP-binding site [chemical binding]; other site 585035002418 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 585035002419 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 585035002420 DEAD_2; Region: DEAD_2; pfam06733 585035002421 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 585035002422 glycosyl transferase family protein; Provisional; Region: PRK08136 585035002423 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 585035002424 putative dehydrogenase; Provisional; Region: PRK10098 585035002425 hypothetical protein; Provisional; Region: PRK10259 585035002426 hypothetical protein; Provisional; Region: PRK11019 585035002427 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 585035002428 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 585035002429 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585035002430 N-terminal plug; other site 585035002431 ligand-binding site [chemical binding]; other site 585035002432 hypothetical protein; Provisional; Region: PRK10259 585035002433 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 585035002434 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 585035002435 putative mechanosensitive channel protein; Provisional; Region: PRK11465 585035002436 Mechanosensitive ion channel; Region: MS_channel; pfam00924 585035002437 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 585035002438 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 585035002439 Walker A/P-loop; other site 585035002440 ATP binding site [chemical binding]; other site 585035002441 Q-loop/lid; other site 585035002442 ABC transporter signature motif; other site 585035002443 Walker B; other site 585035002444 D-loop; other site 585035002445 H-loop/switch region; other site 585035002446 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585035002447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035002448 dimer interface [polypeptide binding]; other site 585035002449 conserved gate region; other site 585035002450 putative PBP binding loops; other site 585035002451 ABC-ATPase subunit interface; other site 585035002452 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 585035002453 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585035002454 substrate binding pocket [chemical binding]; other site 585035002455 membrane-bound complex binding site; other site 585035002456 hinge residues; other site 585035002457 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 585035002458 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 585035002459 dimerization interface [polypeptide binding]; other site 585035002460 DPS ferroxidase diiron center [ion binding]; other site 585035002461 ion pore; other site 585035002462 threonine and homoserine efflux system; Provisional; Region: PRK10532 585035002463 EamA-like transporter family; Region: EamA; pfam00892 585035002464 outer membrane protein X; Provisional; Region: ompX; PRK09408 585035002465 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 585035002466 Sulfatase; Region: Sulfatase; pfam00884 585035002467 manganese transport regulator MntR; Provisional; Region: PRK11050 585035002468 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 585035002469 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 585035002470 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 585035002471 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 585035002472 transmembrane helices; other site 585035002473 L,D-transpeptidase; Provisional; Region: PRK10260 585035002474 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585035002475 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 585035002476 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585035002477 Walker A/P-loop; other site 585035002478 ATP binding site [chemical binding]; other site 585035002479 Q-loop/lid; other site 585035002480 ABC transporter signature motif; other site 585035002481 Walker B; other site 585035002482 D-loop; other site 585035002483 H-loop/switch region; other site 585035002484 ABC transporter; Region: ABC_tran_2; pfam12848 585035002485 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 585035002486 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 585035002487 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585035002488 active site 585035002489 motif I; other site 585035002490 motif II; other site 585035002491 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585035002492 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 585035002493 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 585035002494 dimer interface [polypeptide binding]; other site 585035002495 active site 585035002496 glycine loop; other site 585035002497 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 585035002498 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 585035002499 active site 585035002500 intersubunit interactions; other site 585035002501 catalytic residue [active] 585035002502 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 585035002503 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 585035002504 ATP binding site [chemical binding]; other site 585035002505 substrate interface [chemical binding]; other site 585035002506 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 585035002507 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 585035002508 dimer interface [polypeptide binding]; other site 585035002509 putative functional site; other site 585035002510 putative MPT binding site; other site 585035002511 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 585035002512 catalytic nucleophile [active] 585035002513 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 585035002514 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585035002515 Walker A/P-loop; other site 585035002516 ATP binding site [chemical binding]; other site 585035002517 Q-loop/lid; other site 585035002518 ABC transporter signature motif; other site 585035002519 Walker B; other site 585035002520 D-loop; other site 585035002521 H-loop/switch region; other site 585035002522 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 585035002523 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585035002524 Walker A/P-loop; other site 585035002525 ATP binding site [chemical binding]; other site 585035002526 Q-loop/lid; other site 585035002527 ABC transporter signature motif; other site 585035002528 Walker B; other site 585035002529 D-loop; other site 585035002530 H-loop/switch region; other site 585035002531 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 585035002532 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 585035002533 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 585035002534 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 585035002535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035002536 dimer interface [polypeptide binding]; other site 585035002537 conserved gate region; other site 585035002538 putative PBP binding loops; other site 585035002539 ABC-ATPase subunit interface; other site 585035002540 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 585035002541 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 585035002542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035002543 dimer interface [polypeptide binding]; other site 585035002544 conserved gate region; other site 585035002545 putative PBP binding loops; other site 585035002546 ABC-ATPase subunit interface; other site 585035002547 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585035002548 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585035002549 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585035002550 metal binding site [ion binding]; metal-binding site 585035002551 active site 585035002552 I-site; other site 585035002553 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 585035002554 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 585035002555 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585035002556 FeS/SAM binding site; other site 585035002557 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 585035002558 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 585035002559 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 585035002560 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 585035002561 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 585035002562 putative C-terminal domain interface [polypeptide binding]; other site 585035002563 putative GSH binding site (G-site) [chemical binding]; other site 585035002564 putative dimer interface [polypeptide binding]; other site 585035002565 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 585035002566 N-terminal domain interface [polypeptide binding]; other site 585035002567 dimer interface [polypeptide binding]; other site 585035002568 substrate binding pocket (H-site) [chemical binding]; other site 585035002569 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 585035002570 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 585035002571 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 585035002572 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 585035002573 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585035002574 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585035002575 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 585035002576 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 585035002577 active site 585035002578 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 585035002579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035002580 putative substrate translocation pore; other site 585035002581 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 585035002582 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585035002583 active site 585035002584 motif I; other site 585035002585 motif II; other site 585035002586 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585035002587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035002588 putative substrate translocation pore; other site 585035002589 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585035002590 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 585035002591 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585035002592 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 585035002593 putative transporter; Provisional; Region: PRK04972 585035002594 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 585035002595 TrkA-C domain; Region: TrkA_C; pfam02080 585035002596 TrkA-C domain; Region: TrkA_C; pfam02080 585035002597 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 585035002598 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 585035002599 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 585035002600 GSH binding site [chemical binding]; other site 585035002601 catalytic residues [active] 585035002602 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 585035002603 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 585035002604 dimer interface [polypeptide binding]; other site 585035002605 FMN binding site [chemical binding]; other site 585035002606 NADPH bind site [chemical binding]; other site 585035002607 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 585035002608 RimK-like ATP-grasp domain; Region: RimK; pfam08443 585035002609 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 585035002610 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 585035002611 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 585035002612 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 585035002613 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585035002614 Walker A/P-loop; other site 585035002615 ATP binding site [chemical binding]; other site 585035002616 Q-loop/lid; other site 585035002617 ABC transporter signature motif; other site 585035002618 Walker B; other site 585035002619 D-loop; other site 585035002620 H-loop/switch region; other site 585035002621 TOBE domain; Region: TOBE_2; pfam08402 585035002622 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 585035002623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035002624 dimer interface [polypeptide binding]; other site 585035002625 conserved gate region; other site 585035002626 putative PBP binding loops; other site 585035002627 ABC-ATPase subunit interface; other site 585035002628 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 585035002629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035002630 dimer interface [polypeptide binding]; other site 585035002631 conserved gate region; other site 585035002632 putative PBP binding loops; other site 585035002633 ABC-ATPase subunit interface; other site 585035002634 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 585035002635 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 585035002636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035002637 S-adenosylmethionine binding site [chemical binding]; other site 585035002638 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 585035002639 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585035002640 substrate binding pocket [chemical binding]; other site 585035002641 membrane-bound complex binding site; other site 585035002642 hinge residues; other site 585035002643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035002644 dimer interface [polypeptide binding]; other site 585035002645 conserved gate region; other site 585035002646 putative PBP binding loops; other site 585035002647 ABC-ATPase subunit interface; other site 585035002648 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585035002649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035002650 dimer interface [polypeptide binding]; other site 585035002651 conserved gate region; other site 585035002652 putative PBP binding loops; other site 585035002653 ABC-ATPase subunit interface; other site 585035002654 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 585035002655 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585035002656 substrate binding pocket [chemical binding]; other site 585035002657 membrane-bound complex binding site; other site 585035002658 hinge residues; other site 585035002659 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 585035002660 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585035002661 Walker A/P-loop; other site 585035002662 ATP binding site [chemical binding]; other site 585035002663 Q-loop/lid; other site 585035002664 ABC transporter signature motif; other site 585035002665 Walker B; other site 585035002666 D-loop; other site 585035002667 H-loop/switch region; other site 585035002668 Evidence 7 : Gene remnant; Product type lp : lipoprotein 585035002669 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein 585035002670 hypothetical protein; Provisional; Region: PRK02877 585035002671 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 585035002672 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 585035002673 amidase catalytic site [active] 585035002674 Zn binding residues [ion binding]; other site 585035002675 substrate binding site [chemical binding]; other site 585035002676 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 585035002677 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 585035002678 NAD(P) binding site [chemical binding]; other site 585035002679 active site 585035002680 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 585035002681 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 585035002682 putative NAD(P) binding site [chemical binding]; other site 585035002683 putative active site [active] 585035002684 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 585035002685 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 585035002686 tetramer interface [polypeptide binding]; other site 585035002687 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035002688 catalytic residue [active] 585035002689 pyruvate dehydrogenase; Provisional; Region: PRK09124 585035002690 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 585035002691 PYR/PP interface [polypeptide binding]; other site 585035002692 dimer interface [polypeptide binding]; other site 585035002693 tetramer interface [polypeptide binding]; other site 585035002694 TPP binding site [chemical binding]; other site 585035002695 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 585035002696 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 585035002697 TPP-binding site [chemical binding]; other site 585035002698 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 585035002699 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 585035002700 FAD binding pocket [chemical binding]; other site 585035002701 FAD binding motif [chemical binding]; other site 585035002702 phosphate binding motif [ion binding]; other site 585035002703 beta-alpha-beta structure motif; other site 585035002704 NAD binding pocket [chemical binding]; other site 585035002705 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585035002706 catalytic loop [active] 585035002707 iron binding site [ion binding]; other site 585035002708 hybrid cluster protein; Provisional; Region: PRK05290 585035002709 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585035002710 ACS interaction site; other site 585035002711 CODH interaction site; other site 585035002712 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 585035002713 hybrid metal cluster; other site 585035002714 Predicted membrane protein [Function unknown]; Region: COG2431 585035002715 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 585035002716 amphipathic channel; other site 585035002717 Asn-Pro-Ala signature motifs; other site 585035002718 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 585035002719 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 585035002720 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 585035002721 putative active site [active] 585035002722 putative metal-binding site [ion binding]; other site 585035002723 Protein of unknown function (DUF535); Region: DUF535; pfam04393 585035002724 macrolide transporter subunit MacA; Provisional; Region: PRK11578 585035002725 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585035002726 HlyD family secretion protein; Region: HlyD_3; pfam13437 585035002727 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 585035002728 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 585035002729 Walker A/P-loop; other site 585035002730 ATP binding site [chemical binding]; other site 585035002731 Q-loop/lid; other site 585035002732 ABC transporter signature motif; other site 585035002733 Walker B; other site 585035002734 D-loop; other site 585035002735 H-loop/switch region; other site 585035002736 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 585035002737 FtsX-like permease family; Region: FtsX; pfam02687 585035002738 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585035002739 DNA-binding site [nucleotide binding]; DNA binding site 585035002740 RNA-binding motif; other site 585035002741 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 585035002742 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 585035002743 Clp amino terminal domain; Region: Clp_N; pfam02861 585035002744 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035002745 Walker A motif; other site 585035002746 ATP binding site [chemical binding]; other site 585035002747 Walker B motif; other site 585035002748 arginine finger; other site 585035002749 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035002750 Walker A motif; other site 585035002751 ATP binding site [chemical binding]; other site 585035002752 Walker B motif; other site 585035002753 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 585035002754 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-F; cd09718 585035002755 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 585035002756 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 585035002757 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09735 585035002758 Evidence 4 : Homologs of previously reported genes of unknown function 585035002759 Evidence 4 : Homologs of previously reported genes of unknown function 585035002760 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 585035002761 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739 585035002762 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 585035002763 rRNA binding site [nucleotide binding]; other site 585035002764 predicted 30S ribosome binding site; other site 585035002765 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 585035002766 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 585035002767 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585035002768 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 585035002769 Walker A/P-loop; other site 585035002770 ATP binding site [chemical binding]; other site 585035002771 Q-loop/lid; other site 585035002772 ABC transporter signature motif; other site 585035002773 Walker B; other site 585035002774 D-loop; other site 585035002775 H-loop/switch region; other site 585035002776 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 585035002777 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585035002778 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585035002779 Walker A/P-loop; other site 585035002780 ATP binding site [chemical binding]; other site 585035002781 Q-loop/lid; other site 585035002782 ABC transporter signature motif; other site 585035002783 Walker B; other site 585035002784 D-loop; other site 585035002785 H-loop/switch region; other site 585035002786 thioredoxin reductase; Provisional; Region: PRK10262 585035002787 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585035002788 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585035002789 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 585035002790 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585035002791 putative DNA binding site [nucleotide binding]; other site 585035002792 putative Zn2+ binding site [ion binding]; other site 585035002793 AsnC family; Region: AsnC_trans_reg; pfam01037 585035002794 DNA translocase FtsK; Provisional; Region: PRK10263 585035002795 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 585035002796 DNA translocase FtsK; Provisional; Region: PRK10263 585035002797 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 585035002798 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 585035002799 periplasmic chaperone LolA; Region: lolA; TIGR00547 585035002800 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 585035002801 recombination factor protein RarA; Reviewed; Region: PRK13342 585035002802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035002803 Walker A motif; other site 585035002804 ATP binding site [chemical binding]; other site 585035002805 Walker B motif; other site 585035002806 arginine finger; other site 585035002807 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 585035002808 seryl-tRNA synthetase; Provisional; Region: PRK05431 585035002809 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 585035002810 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 585035002811 dimer interface [polypeptide binding]; other site 585035002812 active site 585035002813 motif 1; other site 585035002814 motif 2; other site 585035002815 motif 3; other site 585035002816 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 585035002817 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 585035002818 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 585035002819 putative [Fe4-S4] binding site [ion binding]; other site 585035002820 putative molybdopterin cofactor binding site [chemical binding]; other site 585035002821 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 585035002822 putative molybdopterin cofactor binding site; other site 585035002823 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 585035002824 4Fe-4S binding domain; Region: Fer4; pfam00037 585035002825 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 585035002826 Isochorismatase family; Region: Isochorismatase; pfam00857 585035002827 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 585035002828 catalytic triad [active] 585035002829 dimer interface [polypeptide binding]; other site 585035002830 conserved cis-peptide bond; other site 585035002831 putative MFS family transporter protein; Provisional; Region: PRK03633 585035002832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035002833 putative substrate translocation pore; other site 585035002834 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 585035002835 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585035002836 FeS/SAM binding site; other site 585035002837 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 585035002838 Pyruvate formate lyase 1; Region: PFL1; cd01678 585035002839 coenzyme A binding site [chemical binding]; other site 585035002840 active site 585035002841 catalytic residues [active] 585035002842 glycine loop; other site 585035002843 formate transporter; Provisional; Region: PRK10805 585035002844 uncharacterized domain; Region: TIGR00702 585035002845 YcaO-like family; Region: YcaO; pfam02624 585035002846 Predicted membrane protein [Function unknown]; Region: COG2323 585035002847 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 585035002848 homodimer interface [polypeptide binding]; other site 585035002849 substrate-cofactor binding pocket; other site 585035002850 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035002851 catalytic residue [active] 585035002852 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 585035002853 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 585035002854 hinge; other site 585035002855 active site 585035002856 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 585035002857 cytidylate kinase; Provisional; Region: cmk; PRK00023 585035002858 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 585035002859 CMP-binding site; other site 585035002860 The sites determining sugar specificity; other site 585035002861 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 585035002862 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 585035002863 RNA binding site [nucleotide binding]; other site 585035002864 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 585035002865 RNA binding site [nucleotide binding]; other site 585035002866 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 585035002867 RNA binding site [nucleotide binding]; other site 585035002868 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 585035002869 RNA binding site [nucleotide binding]; other site 585035002870 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 585035002871 RNA binding site [nucleotide binding]; other site 585035002872 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 585035002873 IHF dimer interface [polypeptide binding]; other site 585035002874 IHF - DNA interface [nucleotide binding]; other site 585035002875 ComEC family competence protein; Provisional; Region: PRK11539 585035002876 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 585035002877 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 585035002878 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 585035002879 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 585035002880 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585035002881 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 585035002882 Walker A/P-loop; other site 585035002883 ATP binding site [chemical binding]; other site 585035002884 Q-loop/lid; other site 585035002885 ABC transporter signature motif; other site 585035002886 Walker B; other site 585035002887 D-loop; other site 585035002888 H-loop/switch region; other site 585035002889 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 585035002890 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 585035002891 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 585035002892 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 585035002893 hypothetical protein; Provisional; Region: PRK11827 585035002894 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 585035002895 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 585035002896 Ligand binding site; other site 585035002897 oligomer interface; other site 585035002898 hypothetical protein; Provisional; Region: PRK10593 585035002899 Uncharacterized conserved protein [Function unknown]; Region: COG1434 585035002900 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 585035002901 putative active site [active] 585035002902 Methyltransferase domain; Region: Methyltransf_31; pfam13847 585035002903 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035002904 S-adenosylmethionine binding site [chemical binding]; other site 585035002905 condesin subunit F; Provisional; Region: PRK05260 585035002906 condesin subunit E; Provisional; Region: PRK05256 585035002907 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 585035002908 MukB N-terminal; Region: MukB; pfam04310 585035002909 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 585035002910 murein L,D-transpeptidase; Provisional; Region: PRK10594 585035002911 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 585035002912 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585035002913 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585035002914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 585035002915 Peptidase M15; Region: Peptidase_M15_3; cl01194 585035002916 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 585035002917 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 585035002918 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585035002919 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035002920 homodimer interface [polypeptide binding]; other site 585035002921 catalytic residue [active] 585035002922 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585035002923 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 585035002924 trimer interface [polypeptide binding]; other site 585035002925 eyelet of channel; other site 585035002926 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 585035002927 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 585035002928 putative dimer interface [polypeptide binding]; other site 585035002929 putative anticodon binding site; other site 585035002930 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 585035002931 homodimer interface [polypeptide binding]; other site 585035002932 motif 1; other site 585035002933 motif 2; other site 585035002934 active site 585035002935 motif 3; other site 585035002936 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 585035002937 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 585035002938 active site 585035002939 aminopeptidase N; Provisional; Region: pepN; PRK14015 585035002940 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 585035002941 active site 585035002942 Zn binding site [ion binding]; other site 585035002943 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 585035002944 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 585035002945 Walker A/P-loop; other site 585035002946 ATP binding site [chemical binding]; other site 585035002947 Q-loop/lid; other site 585035002948 ABC transporter signature motif; other site 585035002949 Walker B; other site 585035002950 D-loop; other site 585035002951 H-loop/switch region; other site 585035002952 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 585035002953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035002954 dimer interface [polypeptide binding]; other site 585035002955 conserved gate region; other site 585035002956 putative PBP binding loops; other site 585035002957 ABC-ATPase subunit interface; other site 585035002958 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 585035002959 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 585035002960 active site 585035002961 dimer interface [polypeptide binding]; other site 585035002962 non-prolyl cis peptide bond; other site 585035002963 insertion regions; other site 585035002964 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585035002965 substrate binding pocket [chemical binding]; other site 585035002966 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 585035002967 membrane-bound complex binding site; other site 585035002968 hinge residues; other site 585035002969 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 585035002970 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 585035002971 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 585035002972 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 585035002973 quinone interaction residues [chemical binding]; other site 585035002974 active site 585035002975 catalytic residues [active] 585035002976 FMN binding site [chemical binding]; other site 585035002977 substrate binding site [chemical binding]; other site 585035002978 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 585035002979 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 585035002980 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 585035002981 MOSC domain; Region: MOSC; pfam03473 585035002982 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585035002983 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 585035002984 catalytic loop [active] 585035002985 iron binding site [ion binding]; other site 585035002986 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 585035002987 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 585035002988 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 585035002989 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035002990 S-adenosylmethionine binding site [chemical binding]; other site 585035002991 ABC transporter ATPase component; Reviewed; Region: PRK11147 585035002992 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585035002993 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585035002994 Walker A/P-loop; other site 585035002995 Walker A/P-loop; other site 585035002996 ATP binding site [chemical binding]; other site 585035002997 ATP binding site [chemical binding]; other site 585035002998 Q-loop/lid; other site 585035002999 Q-loop/lid; other site 585035003000 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 585035003001 ABC transporter signature motif; other site 585035003002 Walker B; other site 585035003003 D-loop; other site 585035003004 ABC transporter; Region: ABC_tran_2; pfam12848 585035003005 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 585035003006 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 585035003007 Paraquat-inducible protein A; Region: PqiA; pfam04403 585035003008 Paraquat-inducible protein A; Region: PqiA; pfam04403 585035003009 paraquat-inducible protein B; Provisional; Region: PRK10807 585035003010 mce related protein; Region: MCE; pfam02470 585035003011 mce related protein; Region: MCE; pfam02470 585035003012 mce related protein; Region: MCE; pfam02470 585035003013 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 585035003014 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 585035003015 Protein of unknown function (DUF330); Region: DUF330; pfam03886 585035003016 ribosome modulation factor; Provisional; Region: PRK14563 585035003017 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 585035003018 active site 1 [active] 585035003019 dimer interface [polypeptide binding]; other site 585035003020 active site 2 [active] 585035003021 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 585035003022 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 585035003023 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 585035003024 outer membrane protein A; Reviewed; Region: PRK10808 585035003025 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 585035003026 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585035003027 ligand binding site [chemical binding]; other site 585035003028 cell division inhibitor SulA; Region: sula; TIGR00623 585035003029 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 585035003030 TfoX C-terminal domain; Region: TfoX_C; pfam04994 585035003031 TIGR01666 family membrane protein; Region: YCCS 585035003032 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 585035003033 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 585035003034 Predicted membrane protein [Function unknown]; Region: COG3304 585035003035 Domain of unknown function (DUF307); Region: DUF307; pfam03733 585035003036 Domain of unknown function (DUF307); Region: DUF307; pfam03733 585035003037 DNA helicase IV; Provisional; Region: helD; PRK11054 585035003038 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 585035003039 Part of AAA domain; Region: AAA_19; pfam13245 585035003040 Family description; Region: UvrD_C_2; pfam13538 585035003041 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 585035003042 active site 585035003043 dimer interfaces [polypeptide binding]; other site 585035003044 catalytic residues [active] 585035003045 hypothetical protein; Provisional; Region: PRK03641 585035003046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 585035003047 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 585035003048 heat shock protein HspQ; Provisional; Region: PRK14129 585035003049 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 585035003050 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 585035003051 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 585035003052 putative RNA binding site [nucleotide binding]; other site 585035003053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035003054 S-adenosylmethionine binding site [chemical binding]; other site 585035003055 acylphosphatase; Provisional; Region: PRK14439 585035003056 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 585035003057 sulfur transfer protein TusE; Provisional; Region: PRK11508 585035003058 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 585035003059 YccA-like proteins; Region: YccA_like; cd10433 585035003060 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 585035003061 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 585035003062 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 585035003063 hydrogenase 1 large subunit; Provisional; Region: PRK10170 585035003064 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 585035003065 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 585035003066 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 585035003067 putative substrate-binding site; other site 585035003068 nickel binding site [ion binding]; other site 585035003069 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 585035003070 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 585035003071 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 585035003072 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 585035003073 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 585035003074 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 585035003075 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 585035003076 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 585035003077 catalytic core [active] 585035003078 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 585035003079 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585035003080 DNA-binding site [nucleotide binding]; DNA binding site 585035003081 RNA-binding motif; other site 585035003082 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585035003083 DNA-binding site [nucleotide binding]; DNA binding site 585035003084 RNA-binding motif; other site 585035003085 GnsA/GnsB family; Region: GnsAB; pfam08178 585035003086 4Fe-4S binding domain; Region: Fer4_5; pfam12801 585035003087 4Fe-4S binding domain; Region: Fer4_5; pfam12801 585035003088 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585035003089 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 585035003090 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 585035003091 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 585035003092 dimerization interface [polypeptide binding]; other site 585035003093 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585035003094 dimer interface [polypeptide binding]; other site 585035003095 phosphorylation site [posttranslational modification] 585035003096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035003097 ATP binding site [chemical binding]; other site 585035003098 Mg2+ binding site [ion binding]; other site 585035003099 G-X-G motif; other site 585035003100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035003101 active site 585035003102 phosphorylation site [posttranslational modification] 585035003103 intermolecular recognition site; other site 585035003104 dimerization interface [polypeptide binding]; other site 585035003105 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 585035003106 putative binding surface; other site 585035003107 active site 585035003108 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 585035003109 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 585035003110 putative ligand binding site [chemical binding]; other site 585035003111 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 585035003112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035003113 active site 585035003114 phosphorylation site [posttranslational modification] 585035003115 intermolecular recognition site; other site 585035003116 dimerization interface [polypeptide binding]; other site 585035003117 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585035003118 DNA binding site [nucleotide binding] 585035003119 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 585035003120 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 585035003121 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 585035003122 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 585035003123 molybdopterin cofactor binding site [chemical binding]; other site 585035003124 substrate binding site [chemical binding]; other site 585035003125 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 585035003126 molybdopterin cofactor binding site; other site 585035003127 chaperone protein TorD; Validated; Region: torD; PRK04976 585035003128 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 585035003129 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 585035003130 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 585035003131 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 585035003132 HSP70 interaction site [polypeptide binding]; other site 585035003133 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 585035003134 substrate binding site [polypeptide binding]; other site 585035003135 dimer interface [polypeptide binding]; other site 585035003136 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 585035003137 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 585035003138 catalytic core [active] 585035003139 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 585035003140 hypothetical protein; Provisional; Region: PRK10174 585035003141 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 585035003142 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 585035003143 Evidence 7 : Gene remnant; Product type t : transporter 585035003144 Evidence 7 : Gene remnant; Product type t : transporter 585035003145 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 585035003146 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 585035003147 putative FMN binding site [chemical binding]; other site 585035003148 pyrimidine utilization protein D; Region: RutD; TIGR03611 585035003149 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 585035003150 homotrimer interaction site [polypeptide binding]; other site 585035003151 putative active site [active] 585035003152 Isochorismatase family; Region: Isochorismatase; pfam00857 585035003153 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 585035003154 catalytic triad [active] 585035003155 conserved cis-peptide bond; other site 585035003156 pyrimidine utilization protein A; Region: RutA; TIGR03612 585035003157 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 585035003158 active site 585035003159 dimer interface [polypeptide binding]; other site 585035003160 non-prolyl cis peptide bond; other site 585035003161 insertion regions; other site 585035003162 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 585035003163 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 585035003164 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585035003165 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 585035003166 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 585035003167 Predicted transcriptional regulator [Transcription]; Region: COG3905 585035003168 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 585035003169 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 585035003170 Glutamate binding site [chemical binding]; other site 585035003171 NAD binding site [chemical binding]; other site 585035003172 catalytic residues [active] 585035003173 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 585035003174 Na binding site [ion binding]; other site 585035003175 FTR1 family protein; Region: TIGR00145 585035003176 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 585035003177 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 585035003178 Imelysin; Region: Peptidase_M75; pfam09375 585035003179 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 585035003180 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 585035003181 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 585035003182 hypothetical protein; Provisional; Region: PRK10536 585035003183 putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585 585035003184 N-glycosyltransferase; Provisional; Region: PRK11204 585035003185 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 585035003186 DXD motif; other site 585035003187 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 585035003188 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 585035003189 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 585035003190 putative active site [active] 585035003191 putative metal binding site [ion binding]; other site 585035003192 Evidence 7 : Gene remnant; Product type pm : membrane component 585035003193 Evidence 7 : Gene remnant; Product type pm : membrane component 585035003194 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585035003195 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585035003196 metal binding site [ion binding]; metal-binding site 585035003197 active site 585035003198 I-site; other site 585035003199 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 585035003200 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 585035003201 putative ligand binding site [chemical binding]; other site 585035003202 NAD binding site [chemical binding]; other site 585035003203 dimerization interface [polypeptide binding]; other site 585035003204 catalytic site [active] 585035003205 putative hydrolase; Validated; Region: PRK09248 585035003206 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 585035003207 active site 585035003208 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 585035003209 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 585035003210 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 585035003211 curli assembly protein CsgF; Provisional; Region: PRK10050 585035003212 curli assembly protein CsgE; Provisional; Region: PRK10386 585035003213 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 585035003214 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585035003215 DNA binding residues [nucleotide binding] 585035003216 dimerization interface [polypeptide binding]; other site 585035003217 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 585035003218 Curlin associated repeat; Region: Curlin_rpt; pfam07012 585035003219 Curlin associated repeat; Region: Curlin_rpt; pfam07012 585035003220 major curlin subunit; Provisional; Region: csgA; PRK10051 585035003221 Curlin associated repeat; Region: Curlin_rpt; pfam07012 585035003222 Curlin associated repeat; Region: Curlin_rpt; pfam07012 585035003223 Thin aggregative fimbriae synthesis protein; Region: Tafi-CsgC; pfam10610 585035003224 Fimbrial protein; Region: Fimbrial; cl01416 585035003225 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 585035003226 putative ADP-ribose binding site [chemical binding]; other site 585035003227 putative active site [active] 585035003228 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 585035003229 PLD-like domain; Region: PLDc_2; pfam13091 585035003230 putative active site [active] 585035003231 catalytic site [active] 585035003232 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 585035003233 PLD-like domain; Region: PLDc_2; pfam13091 585035003234 putative active site [active] 585035003235 catalytic site [active] 585035003236 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 585035003237 Acyltransferase family; Region: Acyl_transf_3; pfam01757 585035003238 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 585035003239 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 585035003240 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 585035003241 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 585035003242 Ligand binding site; other site 585035003243 DXD motif; other site 585035003244 lipoprotein; Provisional; Region: PRK10175 585035003245 secY/secA suppressor protein; Provisional; Region: PRK11467 585035003246 drug efflux system protein MdtG; Provisional; Region: PRK09874 585035003247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035003248 putative substrate translocation pore; other site 585035003249 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 585035003250 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 585035003251 putative acyl-acceptor binding pocket; other site 585035003252 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 585035003253 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 585035003254 active site residue [active] 585035003255 hypothetical protein; Provisional; Region: PRK03757 585035003256 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 585035003257 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 585035003258 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 585035003259 hydroxyglutarate oxidase; Provisional; Region: PRK11728 585035003260 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 585035003261 DNA damage-inducible protein I; Provisional; Region: PRK10597 585035003262 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 585035003263 active site 585035003264 substrate binding pocket [chemical binding]; other site 585035003265 dimer interface [polypeptide binding]; other site 585035003266 lipoprotein; Provisional; Region: PRK10598 585035003267 glutaredoxin 2; Provisional; Region: PRK10387 585035003268 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 585035003269 C-terminal domain interface [polypeptide binding]; other site 585035003270 GSH binding site (G-site) [chemical binding]; other site 585035003271 catalytic residues [active] 585035003272 putative dimer interface [polypeptide binding]; other site 585035003273 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 585035003274 N-terminal domain interface [polypeptide binding]; other site 585035003275 multidrug resistance protein MdtH; Provisional; Region: PRK11646 585035003276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035003277 putative substrate translocation pore; other site 585035003278 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 585035003279 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 585035003280 hypothetical protein; Provisional; Region: PRK11239 585035003281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 585035003282 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 585035003283 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 585035003284 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 585035003285 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 585035003286 MviN-like protein; Region: MVIN; pfam03023 585035003287 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 585035003288 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 585035003289 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 585035003290 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 585035003291 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 585035003292 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 585035003293 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 585035003294 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 585035003295 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 585035003296 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 585035003297 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 585035003298 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 585035003299 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 585035003300 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 585035003301 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 585035003302 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 585035003303 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 585035003304 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 585035003305 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 585035003306 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 585035003307 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 585035003308 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 585035003309 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 585035003310 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 585035003311 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 585035003312 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 585035003313 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 585035003314 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 585035003315 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 585035003316 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 585035003317 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 585035003318 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 585035003319 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 585035003320 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 585035003321 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 585035003322 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 585035003323 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 585035003324 homodimer interface [polypeptide binding]; other site 585035003325 oligonucleotide binding site [chemical binding]; other site 585035003326 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 585035003327 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 585035003328 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585035003329 RNA binding surface [nucleotide binding]; other site 585035003330 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 585035003331 active site 585035003332 Maf-like protein; Region: Maf; pfam02545 585035003333 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 585035003334 active site 585035003335 dimer interface [polypeptide binding]; other site 585035003336 hypothetical protein; Provisional; Region: PRK11193 585035003337 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 585035003338 putative phosphate acyltransferase; Provisional; Region: PRK05331 585035003339 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 585035003340 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 585035003341 dimer interface [polypeptide binding]; other site 585035003342 active site 585035003343 CoA binding pocket [chemical binding]; other site 585035003344 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 585035003345 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 585035003346 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 585035003347 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 585035003348 NAD(P) binding site [chemical binding]; other site 585035003349 homotetramer interface [polypeptide binding]; other site 585035003350 homodimer interface [polypeptide binding]; other site 585035003351 active site 585035003352 acyl carrier protein; Provisional; Region: acpP; PRK00982 585035003353 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 585035003354 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 585035003355 dimer interface [polypeptide binding]; other site 585035003356 active site 585035003357 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 585035003358 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 585035003359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035003360 catalytic residue [active] 585035003361 conserved hypothetical protein, YceG family; Region: TIGR00247 585035003362 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 585035003363 dimerization interface [polypeptide binding]; other site 585035003364 thymidylate kinase; Validated; Region: tmk; PRK00698 585035003365 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 585035003366 TMP-binding site; other site 585035003367 ATP-binding site [chemical binding]; other site 585035003368 DNA polymerase III subunit delta'; Validated; Region: PRK07993 585035003369 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 585035003370 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 585035003371 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 585035003372 active site 585035003373 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 585035003374 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 585035003375 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585035003376 active site turn [active] 585035003377 phosphorylation site [posttranslational modification] 585035003378 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 585035003379 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585035003380 N-terminal plug; other site 585035003381 ligand-binding site [chemical binding]; other site 585035003382 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 585035003383 nucleotide binding site/active site [active] 585035003384 HIT family signature motif; other site 585035003385 catalytic residue [active] 585035003386 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 585035003387 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 585035003388 putative dimer interface [polypeptide binding]; other site 585035003389 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 585035003390 thiamine kinase; Region: ycfN_thiK; TIGR02721 585035003391 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 585035003392 active site 585035003393 substrate binding site [chemical binding]; other site 585035003394 ATP binding site [chemical binding]; other site 585035003395 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 585035003396 beta-hexosaminidase; Provisional; Region: PRK05337 585035003397 hypothetical protein; Provisional; Region: PRK04940 585035003398 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 585035003399 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585035003400 hypothetical protein; Provisional; Region: PRK11280 585035003401 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 585035003402 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585035003403 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585035003404 L,D-transpeptidase; Provisional; Region: PRK10260 585035003405 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585035003406 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585035003407 transcription-repair coupling factor; Provisional; Region: PRK10689 585035003408 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 585035003409 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585035003410 ATP binding site [chemical binding]; other site 585035003411 putative Mg++ binding site [ion binding]; other site 585035003412 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585035003413 nucleotide binding region [chemical binding]; other site 585035003414 ATP-binding site [chemical binding]; other site 585035003415 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 585035003416 Predicted membrane protein [Function unknown]; Region: COG4763 585035003417 Acyltransferase family; Region: Acyl_transf_3; pfam01757 585035003418 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 585035003419 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 585035003420 FtsX-like permease family; Region: FtsX; pfam02687 585035003421 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 585035003422 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 585035003423 Walker A/P-loop; other site 585035003424 ATP binding site [chemical binding]; other site 585035003425 Q-loop/lid; other site 585035003426 ABC transporter signature motif; other site 585035003427 Walker B; other site 585035003428 D-loop; other site 585035003429 H-loop/switch region; other site 585035003430 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 585035003431 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 585035003432 FtsX-like permease family; Region: FtsX; pfam02687 585035003433 fructokinase; Reviewed; Region: PRK09557 585035003434 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585035003435 nucleotide binding site [chemical binding]; other site 585035003436 NAD-dependent deacetylase; Provisional; Region: PRK00481 585035003437 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 585035003438 NAD+ binding site [chemical binding]; other site 585035003439 substrate binding site [chemical binding]; other site 585035003440 Zn binding site [ion binding]; other site 585035003441 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 585035003442 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 585035003443 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 585035003444 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 585035003445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035003446 dimer interface [polypeptide binding]; other site 585035003447 conserved gate region; other site 585035003448 putative PBP binding loops; other site 585035003449 ABC-ATPase subunit interface; other site 585035003450 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 585035003451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035003452 dimer interface [polypeptide binding]; other site 585035003453 conserved gate region; other site 585035003454 putative PBP binding loops; other site 585035003455 ABC-ATPase subunit interface; other site 585035003456 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 585035003457 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585035003458 Walker A/P-loop; other site 585035003459 ATP binding site [chemical binding]; other site 585035003460 Q-loop/lid; other site 585035003461 ABC transporter signature motif; other site 585035003462 Walker B; other site 585035003463 D-loop; other site 585035003464 H-loop/switch region; other site 585035003465 TOBE domain; Region: TOBE_2; pfam08402 585035003466 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 585035003467 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 585035003468 metal binding site [ion binding]; metal-binding site 585035003469 dimer interface [polypeptide binding]; other site 585035003470 Uncharacterized conserved protein [Function unknown]; Region: COG2850 585035003471 Cupin-like domain; Region: Cupin_8; pfam13621 585035003472 sensor protein PhoQ; Provisional; Region: PRK10815 585035003473 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 585035003474 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 585035003475 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 585035003476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035003477 ATP binding site [chemical binding]; other site 585035003478 Mg2+ binding site [ion binding]; other site 585035003479 G-X-G motif; other site 585035003480 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 585035003481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035003482 active site 585035003483 phosphorylation site [posttranslational modification] 585035003484 intermolecular recognition site; other site 585035003485 dimerization interface [polypeptide binding]; other site 585035003486 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585035003487 DNA binding site [nucleotide binding] 585035003488 adenylosuccinate lyase; Provisional; Region: PRK09285 585035003489 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 585035003490 tetramer interface [polypeptide binding]; other site 585035003491 active site 585035003492 putative lysogenization regulator; Reviewed; Region: PRK00218 585035003493 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 585035003494 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 585035003495 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 585035003496 nudix motif; other site 585035003497 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 585035003498 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 585035003499 probable active site [active] 585035003500 isocitrate dehydrogenase; Validated; Region: PRK07362 585035003501 isocitrate dehydrogenase; Reviewed; Region: PRK07006 585035003502 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 585035003503 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 585035003504 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 585035003505 dimer interface [polypeptide binding]; other site 585035003506 active site 585035003507 Int/Topo IB signature motif; other site 585035003508 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 585035003509 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 585035003510 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 585035003511 Protein of unknown function (DUF1317); Region: DUF1317; pfam07026 585035003512 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 585035003513 phage recombination protein Bet; Region: bet_lambda; TIGR01913 585035003514 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 585035003515 Lambda Phage CIII; Region: Lambda_CIII; pfam02061 585035003516 Protein of unknown function (DUF2528); Region: DUF2528; pfam10800 585035003517 Antirestriction protein Ral; Region: Ral; pfam11058 585035003518 similar to conserved hypothetical protein from phage origin; Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin 585035003519 Superinfection exclusion protein B; Region: SieB; pfam14163 585035003520 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 585035003521 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 585035003522 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585035003523 non-specific DNA binding site [nucleotide binding]; other site 585035003524 salt bridge; other site 585035003525 sequence-specific DNA binding site [nucleotide binding]; other site 585035003526 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585035003527 Catalytic site [active] 585035003528 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 585035003529 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585035003530 non-specific DNA binding site [nucleotide binding]; other site 585035003531 salt bridge; other site 585035003532 sequence-specific DNA binding site [nucleotide binding]; other site 585035003533 Bacteriophage CII protein; Region: Phage_CII; pfam05269 585035003534 Evidence 2b : Function of strongly homologous gene; PubMedId : 704348; Product type h : extrachromosomal origin 585035003535 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 704348, 264238; Product type h : extrachromosomal origin 585035003536 Replication protein P; Region: Phage_lambda_P; pfam06992 585035003537 NinB protein; Region: NinB; pfam05772 585035003538 phage N-6-adenine-methyltransferase; Region: phage_N6A_met; TIGR01712 585035003539 hypothetical protein; Region: PHA01519 585035003540 endodeoxyribonuclease RUS; Reviewed; Region: PRK09786 585035003541 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 585035003542 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585035003543 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 585035003544 trimer interface [polypeptide binding]; other site 585035003545 eyelet of channel; other site 585035003546 Lysis protein S; Region: Lysis_S; pfam04971 585035003547 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585035003548 catalytic residues [active] 585035003549 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585035003550 Bor protein; Region: Lambda_Bor; pfam06291 585035003551 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 585035003552 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 585035003553 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 585035003554 gpW; Region: gpW; pfam02831 585035003555 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 585035003556 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 585035003557 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 585035003558 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 585035003559 tandem repeat interface [polypeptide binding]; other site 585035003560 oligomer interface [polypeptide binding]; other site 585035003561 active site residues [active] 585035003562 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 585035003563 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 585035003564 DNA packaging protein FI; Region: Packaging_FI; pfam14000 585035003565 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 585035003566 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 585035003567 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 585035003568 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 585035003569 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 585035003570 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 585035003571 Minor tail protein T; Region: Phage_tail_T; pfam06223 585035003572 Phage-related minor tail protein [Function unknown]; Region: COG5281 585035003573 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 585035003574 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 585035003575 Phage-related protein [Function unknown]; Region: COG4718 585035003576 Phage-related protein [Function unknown]; Region: gp18; COG4672 585035003577 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 585035003578 MPN+ (JAMM) motif; other site 585035003579 Zinc-binding site [ion binding]; other site 585035003580 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585035003581 NlpC/P60 family; Region: NLPC_P60; cl17555 585035003582 Phage-related protein, tail component [Function unknown]; Region: COG4723 585035003583 Phage-related protein, tail component [Function unknown]; Region: COG4733 585035003584 Putative phage tail protein; Region: Phage-tail_3; pfam13550 585035003585 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 585035003586 Interdomain contacts; other site 585035003587 Cytokine receptor motif; other site 585035003588 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 585035003589 Fibronectin type III protein; Region: DUF3672; pfam12421 585035003590 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 585035003591 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 585035003592 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 585035003593 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585035003594 ABC-ATPase subunit interface; other site 585035003595 dimer interface [polypeptide binding]; other site 585035003596 putative PBP binding regions; other site 585035003597 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 585035003598 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585035003599 ABC-ATPase subunit interface; other site 585035003600 dimer interface [polypeptide binding]; other site 585035003601 putative PBP binding regions; other site 585035003602 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 585035003603 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 585035003604 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 585035003605 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 585035003606 metal binding site [ion binding]; metal-binding site 585035003607 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 585035003608 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 585035003609 transcriptional regulator MirA; Provisional; Region: PRK15043 585035003610 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 585035003611 DNA binding residues [nucleotide binding] 585035003612 Sensors of blue-light using FAD; Region: BLUF; smart01034 585035003613 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585035003614 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 585035003615 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 585035003616 Evidence 7 : Gene remnant; Product type pm : membrane component 585035003617 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 585035003618 Autotransporter beta-domain; Region: Autotransporter; cl17461 585035003619 Evidence 7 : Gene remnant; Product type t : transporter 585035003620 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 585035003621 cell division inhibitor MinD; Provisional; Region: PRK10818 585035003622 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 585035003623 Switch I; other site 585035003624 Switch II; other site 585035003625 septum formation inhibitor; Reviewed; Region: minC; PRK03511 585035003626 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 585035003627 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 585035003628 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 585035003629 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 585035003630 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 585035003631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 585035003632 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 585035003633 hypothetical protein; Provisional; Region: PRK10691 585035003634 hypothetical protein; Provisional; Region: PRK05170 585035003635 Evidence 7 : Gene remnant; Product type c : carrier 585035003636 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 585035003637 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585035003638 Catalytic site [active] 585035003639 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 585035003640 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 585035003641 active site 585035003642 DNA binding site [nucleotide binding] 585035003643 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 585035003644 disulfide bond formation protein B; Provisional; Region: PRK01749 585035003645 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 585035003646 transmembrane helices; other site 585035003647 fatty acid metabolism regulator; Provisional; Region: PRK04984 585035003648 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585035003649 DNA-binding site [nucleotide binding]; DNA binding site 585035003650 FadR C-terminal domain; Region: FadR_C; pfam07840 585035003651 SpoVR family protein; Provisional; Region: PRK11767 585035003652 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 585035003653 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 585035003654 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585035003655 alanine racemase; Reviewed; Region: dadX; PRK03646 585035003656 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 585035003657 active site 585035003658 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585035003659 substrate binding site [chemical binding]; other site 585035003660 catalytic residues [active] 585035003661 dimer interface [polypeptide binding]; other site 585035003662 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 585035003663 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 585035003664 TrkA-C domain; Region: TrkA_C; pfam02080 585035003665 Transporter associated domain; Region: CorC_HlyC; smart01091 585035003666 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 585035003667 dimer interface [polypeptide binding]; other site 585035003668 catalytic triad [active] 585035003669 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 585035003670 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585035003671 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585035003672 catalytic residue [active] 585035003673 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 585035003674 Flagellar regulator YcgR; Region: YcgR; pfam07317 585035003675 PilZ domain; Region: PilZ; pfam07238 585035003676 hypothetical protein; Provisional; Region: PRK10457 585035003677 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585035003678 N-terminal plug; other site 585035003679 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 585035003680 ligand-binding site [chemical binding]; other site 585035003681 molybdenum transport protein ModD; Provisional; Region: PRK06096 585035003682 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 585035003683 dimerization interface [polypeptide binding]; other site 585035003684 active site 585035003685 Methyltransferase domain; Region: Methyltransf_31; pfam13847 585035003686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035003687 S-adenosylmethionine binding site [chemical binding]; other site 585035003688 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 585035003689 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 585035003690 Walker A/P-loop; other site 585035003691 ATP binding site [chemical binding]; other site 585035003692 Q-loop/lid; other site 585035003693 ABC transporter signature motif; other site 585035003694 Walker B; other site 585035003695 D-loop; other site 585035003696 H-loop/switch region; other site 585035003697 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 585035003698 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585035003699 ABC-ATPase subunit interface; other site 585035003700 dimer interface [polypeptide binding]; other site 585035003701 putative PBP binding regions; other site 585035003702 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 585035003703 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 585035003704 putative metal binding site [ion binding]; other site 585035003705 trehalase; Provisional; Region: treA; PRK13271 585035003706 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 585035003707 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 585035003708 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 585035003709 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585035003710 dimerization domain swap beta strand [polypeptide binding]; other site 585035003711 regulatory protein interface [polypeptide binding]; other site 585035003712 active site 585035003713 regulatory phosphorylation site [posttranslational modification]; other site 585035003714 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 585035003715 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 585035003716 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 585035003717 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 585035003718 Dak1 domain; Region: Dak1; pfam02733 585035003719 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 585035003720 PAS domain; Region: PAS; smart00091 585035003721 putative active site [active] 585035003722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035003723 Walker A motif; other site 585035003724 ATP binding site [chemical binding]; other site 585035003725 Walker B motif; other site 585035003726 arginine finger; other site 585035003727 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585035003728 Probable pectinesterase/pectinesterase inhibitor; Region: PLN02708 585035003729 GTP-binding protein YchF; Reviewed; Region: PRK09601 585035003730 YchF GTPase; Region: YchF; cd01900 585035003731 G1 box; other site 585035003732 GTP/Mg2+ binding site [chemical binding]; other site 585035003733 Switch I region; other site 585035003734 G2 box; other site 585035003735 Switch II region; other site 585035003736 G3 box; other site 585035003737 G4 box; other site 585035003738 G5 box; other site 585035003739 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 585035003740 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 585035003741 putative active site [active] 585035003742 catalytic residue [active] 585035003743 hypothetical protein; Provisional; Region: PRK10692 585035003744 putative transporter; Provisional; Region: PRK11660 585035003745 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 585035003746 Sulfate transporter family; Region: Sulfate_transp; pfam00916 585035003747 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 585035003748 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 585035003749 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 585035003750 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585035003751 active site 585035003752 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 585035003753 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 585035003754 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 585035003755 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 585035003756 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 585035003757 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 585035003758 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 585035003759 tRNA; other site 585035003760 putative tRNA binding site [nucleotide binding]; other site 585035003761 putative NADP binding site [chemical binding]; other site 585035003762 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 585035003763 peptide chain release factor 1; Validated; Region: prfA; PRK00591 585035003764 This domain is found in peptide chain release factors; Region: PCRF; smart00937 585035003765 RF-1 domain; Region: RF-1; pfam00472 585035003766 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 585035003767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035003768 hypothetical protein; Provisional; Region: PRK10278 585035003769 hypothetical protein; Provisional; Region: PRK10941 585035003770 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 585035003771 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 585035003772 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 585035003773 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 585035003774 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 585035003775 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 585035003776 cation transport regulator; Reviewed; Region: chaB; PRK09582 585035003777 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 585035003778 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 585035003779 putative active site pocket [active] 585035003780 dimerization interface [polypeptide binding]; other site 585035003781 putative catalytic residue [active] 585035003782 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 585035003783 putative invasin; Provisional; Region: PRK10177 585035003784 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 585035003785 transcriptional regulator NarL; Provisional; Region: PRK10651 585035003786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035003787 active site 585035003788 phosphorylation site [posttranslational modification] 585035003789 intermolecular recognition site; other site 585035003790 dimerization interface [polypeptide binding]; other site 585035003791 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585035003792 DNA binding residues [nucleotide binding] 585035003793 dimerization interface [polypeptide binding]; other site 585035003794 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 585035003795 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 585035003796 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585035003797 dimerization interface [polypeptide binding]; other site 585035003798 Histidine kinase; Region: HisKA_3; pfam07730 585035003799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035003800 ATP binding site [chemical binding]; other site 585035003801 Mg2+ binding site [ion binding]; other site 585035003802 G-X-G motif; other site 585035003803 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 585035003804 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 585035003805 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 585035003806 [4Fe-4S] binding site [ion binding]; other site 585035003807 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585035003808 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585035003809 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585035003810 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 585035003811 molybdopterin cofactor binding site; other site 585035003812 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 585035003813 4Fe-4S binding domain; Region: Fer4; cl02805 585035003814 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 585035003815 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 585035003816 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 585035003817 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 585035003818 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 585035003819 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 585035003820 putative active site [active] 585035003821 putative substrate binding site [chemical binding]; other site 585035003822 putative cosubstrate binding site; other site 585035003823 catalytic site [active] 585035003824 SEC-C motif; Region: SEC-C; pfam02810 585035003825 hypothetical protein; Provisional; Region: PRK04233 585035003826 hypothetical protein; Provisional; Region: PRK10279 585035003827 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 585035003828 active site 585035003829 nucleophile elbow; other site 585035003830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035003831 active site 585035003832 response regulator of RpoS; Provisional; Region: PRK10693 585035003833 phosphorylation site [posttranslational modification] 585035003834 intermolecular recognition site; other site 585035003835 dimerization interface [polypeptide binding]; other site 585035003836 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 585035003837 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 585035003838 active site 585035003839 tetramer interface; other site 585035003840 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 585035003841 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 585035003842 thymidine kinase; Provisional; Region: PRK04296 585035003843 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 585035003844 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 585035003845 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 585035003846 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 585035003847 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 585035003848 putative catalytic cysteine [active] 585035003849 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 585035003850 putative active site [active] 585035003851 metal binding site [ion binding]; metal-binding site 585035003852 hypothetical protein; Provisional; Region: PRK11111 585035003853 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 585035003854 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 585035003855 peptide binding site [polypeptide binding]; other site 585035003856 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 585035003857 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035003858 dimer interface [polypeptide binding]; other site 585035003859 conserved gate region; other site 585035003860 putative PBP binding loops; other site 585035003861 ABC-ATPase subunit interface; other site 585035003862 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 585035003863 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 585035003864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035003865 dimer interface [polypeptide binding]; other site 585035003866 conserved gate region; other site 585035003867 putative PBP binding loops; other site 585035003868 ABC-ATPase subunit interface; other site 585035003869 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 585035003870 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585035003871 Walker A/P-loop; other site 585035003872 ATP binding site [chemical binding]; other site 585035003873 Q-loop/lid; other site 585035003874 ABC transporter signature motif; other site 585035003875 Walker B; other site 585035003876 D-loop; other site 585035003877 H-loop/switch region; other site 585035003878 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 585035003879 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 585035003880 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585035003881 Walker A/P-loop; other site 585035003882 ATP binding site [chemical binding]; other site 585035003883 Q-loop/lid; other site 585035003884 ABC transporter signature motif; other site 585035003885 Walker B; other site 585035003886 D-loop; other site 585035003887 H-loop/switch region; other site 585035003888 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 585035003889 dsDNA-mimic protein; Reviewed; Region: PRK05094 585035003890 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 585035003891 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 585035003892 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 585035003893 putative active site [active] 585035003894 catalytic site [active] 585035003895 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 585035003896 putative active site [active] 585035003897 catalytic site [active] 585035003898 voltage-gated potassium channel; Provisional; Region: PRK10537 585035003899 Ion channel; Region: Ion_trans_2; pfam07885 585035003900 TrkA-N domain; Region: TrkA_N; pfam02254 585035003901 YciI-like protein; Reviewed; Region: PRK11370 585035003902 transport protein TonB; Provisional; Region: PRK10819 585035003903 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 585035003904 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 585035003905 intracellular septation protein A; Reviewed; Region: PRK00259 585035003906 hypothetical protein; Provisional; Region: PRK02868 585035003907 outer membrane protein W; Provisional; Region: PRK10959 585035003908 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 585035003909 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 585035003910 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 585035003911 dimer interface [polypeptide binding]; other site 585035003912 active site 585035003913 Int/Topo IB signature motif; other site 585035003914 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 585035003915 active site 585035003916 catalytic site [active] 585035003917 substrate binding site [chemical binding]; other site 585035003918 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 585035003919 DicB protein; Region: DicB; pfam05358 585035003920 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 585035003921 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585035003922 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 585035003923 non-specific DNA binding site [nucleotide binding]; other site 585035003924 salt bridge; other site 585035003925 sequence-specific DNA binding site [nucleotide binding]; other site 585035003926 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585035003927 Catalytic site [active] 585035003928 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 585035003929 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 585035003930 primosomal protein DnaI; Provisional; Region: PRK02854 585035003931 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 585035003932 Protein of unknown function (DUF968); Region: DUF968; pfam06147 585035003933 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 585035003934 Antitermination protein; Region: Antiterm; pfam03589 585035003935 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 585035003936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035003937 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 585035003938 DNA methylase; Region: N6_N4_Mtase; pfam01555 585035003939 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 585035003940 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin 585035003941 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin 585035003942 Lysis protein S; Region: Lysis_S; pfam04971 585035003943 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin 585035003944 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 585035003945 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin 585035003946 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin 585035003947 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585035003948 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 585035003949 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 585035003950 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 585035003951 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 585035003952 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 585035003953 gpW; Region: gpW; pfam02831 585035003954 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 585035003955 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 585035003956 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 585035003957 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 585035003958 tandem repeat interface [polypeptide binding]; other site 585035003959 oligomer interface [polypeptide binding]; other site 585035003960 active site residues [active] 585035003961 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 585035003962 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 585035003963 DNA packaging protein FI; Region: Packaging_FI; pfam14000 585035003964 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 585035003965 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 585035003966 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 585035003967 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 585035003968 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 585035003969 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 585035003970 phage tail assembly protein T; Region: phage_lam_T; TIGR01715 585035003971 Phage-related minor tail protein [Function unknown]; Region: COG5281 585035003972 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 585035003973 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 585035003974 Phage-related protein [Function unknown]; Region: COG4718 585035003975 Phage-related protein [Function unknown]; Region: gp18; COG4672 585035003976 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 585035003977 MPN+ (JAMM) motif; other site 585035003978 Zinc-binding site [ion binding]; other site 585035003979 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585035003980 NlpC/P60 family; Region: NLPC_P60; cl17555 585035003981 Phage-related protein, tail component [Function unknown]; Region: COG4723 585035003982 Phage-related protein, tail component [Function unknown]; Region: COG4733 585035003983 Putative phage tail protein; Region: Phage-tail_3; pfam13550 585035003984 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 585035003985 Fibronectin type III protein; Region: DUF3672; pfam12421 585035003986 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 585035003987 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 585035003988 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 585035003989 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 585035003990 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 585035003991 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 585035003992 Phage Tail Collar Domain; Region: Collar; pfam07484 585035003993 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 585035003994 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 585035003995 Methyltransferase domain; Region: Methyltransf_12; pfam08242 585035003996 S-adenosylmethionine binding site [chemical binding]; other site 585035003997 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 585035003998 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 585035003999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 585035004000 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 585035004001 dimerization interface [polypeptide binding]; other site 585035004002 metal binding site [ion binding]; metal-binding site 585035004003 General stress protein [General function prediction only]; Region: GsiB; COG3729 585035004004 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 585035004005 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 585035004006 substrate binding site [chemical binding]; other site 585035004007 active site 585035004008 catalytic residues [active] 585035004009 heterodimer interface [polypeptide binding]; other site 585035004010 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 585035004011 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 585035004012 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035004013 catalytic residue [active] 585035004014 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 585035004015 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 585035004016 active site 585035004017 ribulose/triose binding site [chemical binding]; other site 585035004018 phosphate binding site [ion binding]; other site 585035004019 substrate (anthranilate) binding pocket [chemical binding]; other site 585035004020 product (indole) binding pocket [chemical binding]; other site 585035004021 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 585035004022 active site 585035004023 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 585035004024 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 585035004025 glutamine binding [chemical binding]; other site 585035004026 catalytic triad [active] 585035004027 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 585035004028 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 585035004029 anthranilate synthase component I; Provisional; Region: PRK13564 585035004030 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 585035004031 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 585035004032 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 585035004033 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 585035004034 active site 585035004035 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 585035004036 hypothetical protein; Provisional; Region: PRK11630 585035004037 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 585035004038 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 585035004039 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585035004040 RNA binding surface [nucleotide binding]; other site 585035004041 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 585035004042 probable active site [active] 585035004043 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 585035004044 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 585035004045 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 585035004046 homodimer interface [polypeptide binding]; other site 585035004047 Walker A motif; other site 585035004048 ATP binding site [chemical binding]; other site 585035004049 hydroxycobalamin binding site [chemical binding]; other site 585035004050 Walker B motif; other site 585035004051 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 585035004052 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 585035004053 NADP binding site [chemical binding]; other site 585035004054 homodimer interface [polypeptide binding]; other site 585035004055 active site 585035004056 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 585035004057 putative inner membrane peptidase; Provisional; Region: PRK11778 585035004058 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 585035004059 tandem repeat interface [polypeptide binding]; other site 585035004060 oligomer interface [polypeptide binding]; other site 585035004061 active site residues [active] 585035004062 hypothetical protein; Provisional; Region: PRK11037 585035004063 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 585035004064 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 585035004065 active site 585035004066 interdomain interaction site; other site 585035004067 putative metal-binding site [ion binding]; other site 585035004068 nucleotide binding site [chemical binding]; other site 585035004069 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 585035004070 domain I; other site 585035004071 DNA binding groove [nucleotide binding] 585035004072 phosphate binding site [ion binding]; other site 585035004073 domain II; other site 585035004074 domain III; other site 585035004075 nucleotide binding site [chemical binding]; other site 585035004076 catalytic site [active] 585035004077 domain IV; other site 585035004078 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 585035004079 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 585035004080 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 585035004081 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 585035004082 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 585035004083 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035004084 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 585035004085 substrate binding site [chemical binding]; other site 585035004086 putative dimerization interface [polypeptide binding]; other site 585035004087 aconitate hydratase; Validated; Region: PRK09277 585035004088 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 585035004089 substrate binding site [chemical binding]; other site 585035004090 ligand binding site [chemical binding]; other site 585035004091 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 585035004092 substrate binding site [chemical binding]; other site 585035004093 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 585035004094 dimerization interface [polypeptide binding]; other site 585035004095 active site 585035004096 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 585035004097 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 585035004098 active site 585035004099 Predicted membrane protein [Function unknown]; Region: COG3771 585035004100 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 585035004101 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 585035004102 TPR motif; other site 585035004103 binding surface 585035004104 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585035004105 binding surface 585035004106 TPR motif; other site 585035004107 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 585035004108 active site 585035004109 dimer interface [polypeptide binding]; other site 585035004110 translation initiation factor Sui1; Validated; Region: PRK06824 585035004111 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 585035004112 putative rRNA binding site [nucleotide binding]; other site 585035004113 lipoprotein; Provisional; Region: PRK10540 585035004114 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 585035004115 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 585035004116 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585035004117 hypothetical protein; Provisional; Region: PRK13658 585035004118 RNase II stability modulator; Provisional; Region: PRK10060 585035004119 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585035004120 putative active site [active] 585035004121 heme pocket [chemical binding]; other site 585035004122 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585035004123 metal binding site [ion binding]; metal-binding site 585035004124 active site 585035004125 I-site; other site 585035004126 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585035004127 exoribonuclease II; Provisional; Region: PRK05054 585035004128 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 585035004129 RNB domain; Region: RNB; pfam00773 585035004130 S1 RNA binding domain; Region: S1; pfam00575 585035004131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 585035004132 Uncharacterized conserved protein [Function unknown]; Region: COG2128 585035004133 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 585035004134 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 585035004135 NAD binding site [chemical binding]; other site 585035004136 homotetramer interface [polypeptide binding]; other site 585035004137 homodimer interface [polypeptide binding]; other site 585035004138 substrate binding site [chemical binding]; other site 585035004139 active site 585035004140 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 585035004141 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585035004142 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 585035004143 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585035004144 HlyD family secretion protein; Region: HlyD_3; pfam13437 585035004145 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 585035004146 Protein export membrane protein; Region: SecD_SecF; cl14618 585035004147 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 585035004148 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 585035004149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035004150 putative substrate translocation pore; other site 585035004151 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 585035004152 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585035004153 Walker A/P-loop; other site 585035004154 ATP binding site [chemical binding]; other site 585035004155 Q-loop/lid; other site 585035004156 ABC transporter signature motif; other site 585035004157 Walker B; other site 585035004158 D-loop; other site 585035004159 H-loop/switch region; other site 585035004160 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 585035004161 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585035004162 Walker A/P-loop; other site 585035004163 ATP binding site [chemical binding]; other site 585035004164 Q-loop/lid; other site 585035004165 ABC transporter signature motif; other site 585035004166 Walker B; other site 585035004167 D-loop; other site 585035004168 H-loop/switch region; other site 585035004169 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 585035004170 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 585035004171 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 585035004172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035004173 dimer interface [polypeptide binding]; other site 585035004174 conserved gate region; other site 585035004175 putative PBP binding loops; other site 585035004176 ABC-ATPase subunit interface; other site 585035004177 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 585035004178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035004179 dimer interface [polypeptide binding]; other site 585035004180 conserved gate region; other site 585035004181 putative PBP binding loops; other site 585035004182 ABC-ATPase subunit interface; other site 585035004183 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 585035004184 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 585035004185 peptide binding site [polypeptide binding]; other site 585035004186 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 585035004187 Evidence 7 : Gene remnant; Product type t : transporter 585035004188 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 585035004189 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035004190 Walker A motif; other site 585035004191 ATP binding site [chemical binding]; other site 585035004192 Walker B motif; other site 585035004193 arginine finger; other site 585035004194 phage shock protein PspA; Provisional; Region: PRK10698 585035004195 phage shock protein B; Provisional; Region: pspB; PRK09458 585035004196 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 585035004197 phage shock protein C; Region: phageshock_pspC; TIGR02978 585035004198 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 585035004199 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 585035004200 active site residue [active] 585035004201 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 585035004202 sucrose phosphorylase; Provisional; Region: PRK13840 585035004203 active site 585035004204 homodimer interface [polypeptide binding]; other site 585035004205 catalytic site [active] 585035004206 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 585035004207 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 585035004208 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 585035004209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035004210 dimer interface [polypeptide binding]; other site 585035004211 conserved gate region; other site 585035004212 putative PBP binding loops; other site 585035004213 ABC-ATPase subunit interface; other site 585035004214 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 585035004215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035004216 dimer interface [polypeptide binding]; other site 585035004217 conserved gate region; other site 585035004218 putative PBP binding loops; other site 585035004219 ABC-ATPase subunit interface; other site 585035004220 Evidence 7 : Gene remnant; Product type pe : enzyme 585035004221 Evidence 7 : Gene remnant; Product type pe : enzyme 585035004222 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 585035004223 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 585035004224 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 585035004225 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 585035004226 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 585035004227 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 585035004228 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 585035004229 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 585035004230 beta-phosphoglucomutase; Region: bPGM; TIGR01990 585035004231 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585035004232 motif II; other site 585035004233 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 585035004234 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 585035004235 Walker A/P-loop; other site 585035004236 ATP binding site [chemical binding]; other site 585035004237 Q-loop/lid; other site 585035004238 ABC transporter signature motif; other site 585035004239 Walker B; other site 585035004240 D-loop; other site 585035004241 H-loop/switch region; other site 585035004242 TOBE domain; Region: TOBE_2; pfam08402 585035004243 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 585035004244 Transcriptional regulators [Transcription]; Region: PurR; COG1609 585035004245 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585035004246 DNA binding site [nucleotide binding] 585035004247 domain linker motif; other site 585035004248 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 585035004249 putative dimerization interface [polypeptide binding]; other site 585035004250 putative ligand binding site [chemical binding]; other site 585035004251 Predicted ATPase [General function prediction only]; Region: COG3106 585035004252 hypothetical protein; Provisional; Region: PRK05415 585035004253 TIGR01620 family protein; Region: hyp_HI0043 585035004254 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 585035004255 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 585035004256 putative aromatic amino acid binding site; other site 585035004257 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035004258 Walker A motif; other site 585035004259 ATP binding site [chemical binding]; other site 585035004260 Walker B motif; other site 585035004261 arginine finger; other site 585035004262 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 585035004263 dimer interface [polypeptide binding]; other site 585035004264 catalytic triad [active] 585035004265 peroxidatic and resolving cysteines [active] 585035004266 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 585035004267 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 585035004268 active site 585035004269 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 585035004270 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 585035004271 putative active site [active] 585035004272 Zn binding site [ion binding]; other site 585035004273 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 585035004274 NADH(P)-binding; Region: NAD_binding_10; pfam13460 585035004275 putative NAD(P) binding site [chemical binding]; other site 585035004276 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 585035004277 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 585035004278 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585035004279 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035004280 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 585035004281 putative effector binding pocket; other site 585035004282 putative dimerization interface [polypeptide binding]; other site 585035004283 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 585035004284 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 585035004285 peptide binding site [polypeptide binding]; other site 585035004286 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 585035004287 Mechanosensitive ion channel; Region: MS_channel; pfam00924 585035004288 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 585035004289 universal stress protein UspE; Provisional; Region: PRK11175 585035004290 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585035004291 Ligand Binding Site [chemical binding]; other site 585035004292 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585035004293 Ligand Binding Site [chemical binding]; other site 585035004294 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 585035004295 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 585035004296 ligand binding site [chemical binding]; other site 585035004297 flexible hinge region; other site 585035004298 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 585035004299 putative switch regulator; other site 585035004300 non-specific DNA interactions [nucleotide binding]; other site 585035004301 DNA binding site [nucleotide binding] 585035004302 sequence specific DNA binding site [nucleotide binding]; other site 585035004303 putative cAMP binding site [chemical binding]; other site 585035004304 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 585035004305 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 585035004306 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 585035004307 DNA binding site [nucleotide binding] 585035004308 active site 585035004309 Evidence 2b : Function of strongly homologous gene; Product type pt : transporter 585035004310 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 585035004311 Helix-turn-helix domain; Region: HTH_18; pfam12833 585035004312 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 585035004313 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585035004314 HlyD family secretion protein; Region: HlyD_3; pfam13437 585035004315 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 585035004316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035004317 putative substrate translocation pore; other site 585035004318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035004319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 585035004320 Smr domain; Region: Smr; pfam01713 585035004321 PAS domain S-box; Region: sensory_box; TIGR00229 585035004322 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585035004323 putative active site [active] 585035004324 heme pocket [chemical binding]; other site 585035004325 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585035004326 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585035004327 metal binding site [ion binding]; metal-binding site 585035004328 active site 585035004329 I-site; other site 585035004330 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 585035004331 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 585035004332 Cl binding site [ion binding]; other site 585035004333 oligomer interface [polypeptide binding]; other site 585035004334 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 585035004335 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 585035004336 ATP binding site [chemical binding]; other site 585035004337 Mg++ binding site [ion binding]; other site 585035004338 motif III; other site 585035004339 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585035004340 nucleotide binding region [chemical binding]; other site 585035004341 ATP-binding site [chemical binding]; other site 585035004342 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 585035004343 putative RNA binding site [nucleotide binding]; other site 585035004344 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 585035004345 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 585035004346 Ligand Binding Site [chemical binding]; other site 585035004347 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme 585035004348 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter 585035004349 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585035004350 Ligand Binding Site [chemical binding]; other site 585035004351 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585035004352 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 585035004353 trimer interface [polypeptide binding]; other site 585035004354 eyelet of channel; other site 585035004355 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 585035004356 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 585035004357 dimer interface [polypeptide binding]; other site 585035004358 PYR/PP interface [polypeptide binding]; other site 585035004359 TPP binding site [chemical binding]; other site 585035004360 substrate binding site [chemical binding]; other site 585035004361 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 585035004362 Domain of unknown function; Region: EKR; smart00890 585035004363 4Fe-4S binding domain; Region: Fer4_6; pfam12837 585035004364 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585035004365 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 585035004366 TPP-binding site [chemical binding]; other site 585035004367 dimer interface [polypeptide binding]; other site 585035004368 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 585035004369 Domain of unknown function (DUF333); Region: DUF333; pfam03891 585035004370 heat-inducible protein; Provisional; Region: PRK10449 585035004371 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 585035004372 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 585035004373 putative ligand binding site [chemical binding]; other site 585035004374 putative NAD binding site [chemical binding]; other site 585035004375 catalytic site [active] 585035004376 hypothetical protein; Provisional; Region: PRK10695 585035004377 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 585035004378 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 585035004379 Autotransporter beta-domain; Region: Autotransporter; pfam03797 585035004380 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585035004381 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585035004382 active site 585035004383 catalytic tetrad [active] 585035004384 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 585035004385 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 585035004386 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 585035004387 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 585035004388 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 585035004389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035004390 S-adenosylmethionine binding site [chemical binding]; other site 585035004391 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 585035004392 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 585035004393 active site 585035004394 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 585035004395 active site 585035004396 catalytic residues [active] 585035004397 azoreductase; Reviewed; Region: PRK00170 585035004398 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 585035004399 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 585035004400 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585035004401 ATP binding site [chemical binding]; other site 585035004402 putative Mg++ binding site [ion binding]; other site 585035004403 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585035004404 nucleotide binding region [chemical binding]; other site 585035004405 ATP-binding site [chemical binding]; other site 585035004406 Helicase associated domain (HA2); Region: HA2; pfam04408 585035004407 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 585035004408 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 585035004409 Uncharacterized conserved protein [Function unknown]; Region: COG1434 585035004410 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 585035004411 putative active site [active] 585035004412 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 585035004413 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 585035004414 NAD binding site [chemical binding]; other site 585035004415 catalytic residues [active] 585035004416 substrate binding site [chemical binding]; other site 585035004417 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 585035004418 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 585035004419 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 585035004420 cytochrome b561; Provisional; Region: PRK11513 585035004421 hypothetical protein; Provisional; Region: PRK10040 585035004422 Evidence 7 : Gene remnant; Product type r : regulator 585035004423 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 585035004424 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035004425 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585035004426 dimerization interface [polypeptide binding]; other site 585035004427 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 585035004428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 585035004429 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 585035004430 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 585035004431 hypothetical protein; Provisional; Region: PRK11415 585035004432 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 585035004433 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585035004434 Coenzyme A binding pocket [chemical binding]; other site 585035004435 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 585035004436 putative trimer interface [polypeptide binding]; other site 585035004437 putative CoA binding site [chemical binding]; other site 585035004438 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 585035004439 putative trimer interface [polypeptide binding]; other site 585035004440 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 585035004441 putative CoA binding site [chemical binding]; other site 585035004442 putative trimer interface [polypeptide binding]; other site 585035004443 putative CoA binding site [chemical binding]; other site 585035004444 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 585035004445 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 585035004446 gating phenylalanine in ion channel; other site 585035004447 tellurite resistance protein TehB; Provisional; Region: PRK11207 585035004448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035004449 S-adenosylmethionine binding site [chemical binding]; other site 585035004450 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 585035004451 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 585035004452 benzoate transporter; Region: benE; TIGR00843 585035004453 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 585035004454 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585035004455 non-specific DNA binding site [nucleotide binding]; other site 585035004456 salt bridge; other site 585035004457 sequence-specific DNA binding site [nucleotide binding]; other site 585035004458 Cupin domain; Region: Cupin_2; pfam07883 585035004459 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 585035004460 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 585035004461 Peptidase family U32; Region: Peptidase_U32; pfam01136 585035004462 Collagenase; Region: DUF3656; pfam12392 585035004463 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 585035004464 Evidence 7 : Gene remnant; Product type pr : regulator 585035004465 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 585035004466 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585035004467 DNA-binding site [nucleotide binding]; DNA binding site 585035004468 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585035004469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035004470 homodimer interface [polypeptide binding]; other site 585035004471 catalytic residue [active] 585035004472 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 585035004473 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 585035004474 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 585035004475 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585035004476 Walker A/P-loop; other site 585035004477 ATP binding site [chemical binding]; other site 585035004478 Q-loop/lid; other site 585035004479 ABC transporter signature motif; other site 585035004480 Walker B; other site 585035004481 D-loop; other site 585035004482 H-loop/switch region; other site 585035004483 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter 585035004484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035004485 dimer interface [polypeptide binding]; other site 585035004486 conserved gate region; other site 585035004487 putative PBP binding loops; other site 585035004488 ABC-ATPase subunit interface; other site 585035004489 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 585035004490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035004491 ABC-ATPase subunit interface; other site 585035004492 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 585035004493 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 585035004494 tetrameric interface [polypeptide binding]; other site 585035004495 NAD binding site [chemical binding]; other site 585035004496 catalytic residues [active] 585035004497 substrate binding site [chemical binding]; other site 585035004498 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 585035004499 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 585035004500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 585035004501 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 585035004502 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 585035004503 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme 585035004504 Evidence 4 : Homologs of previously reported genes of unknown function 585035004505 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 585035004506 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585035004507 N-terminal plug; other site 585035004508 ligand-binding site [chemical binding]; other site 585035004509 PQQ-like domain; Region: PQQ_2; pfam13360 585035004510 L-asparagine permease; Provisional; Region: PRK15049 585035004511 Evidence 7 : Gene remnant; Product type pe : enzyme 585035004512 Evidence 7 : Gene remnant; Product type pe : enzyme 585035004513 PAAR motif; Region: PAAR_motif; pfam05488 585035004514 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 585035004515 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 585035004516 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 585035004517 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 585035004518 Peptidase M35-like domain of uncharacterized proteins; Region: M35_like_1; cd11007 585035004519 putative active site [active] 585035004520 putative Zn binding site [ion binding]; other site 585035004521 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 585035004522 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 585035004523 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 585035004524 hypothetical protein; Provisional; Region: PRK10281 585035004525 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 585035004526 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 585035004527 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 585035004528 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 585035004529 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 585035004530 [4Fe-4S] binding site [ion binding]; other site 585035004531 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585035004532 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585035004533 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585035004534 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 585035004535 molybdopterin cofactor binding site; other site 585035004536 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 585035004537 aromatic amino acid exporter; Provisional; Region: PRK11689 585035004538 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 585035004539 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 585035004540 [4Fe-4S] binding site [ion binding]; other site 585035004541 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585035004542 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 585035004543 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 585035004544 molybdopterin cofactor binding site; other site 585035004545 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 585035004546 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 585035004547 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 585035004548 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 585035004549 Evidence 7 : Gene remnant; Product type pr : regulator 585035004550 Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015 585035004551 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 585035004552 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 585035004553 NAD binding site [chemical binding]; other site 585035004554 substrate binding site [chemical binding]; other site 585035004555 catalytic Zn binding site [ion binding]; other site 585035004556 tetramer interface [polypeptide binding]; other site 585035004557 structural Zn binding site [ion binding]; other site 585035004558 malate dehydrogenase; Provisional; Region: PRK13529 585035004559 Malic enzyme, N-terminal domain; Region: malic; pfam00390 585035004560 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 585035004561 NAD(P) binding site [chemical binding]; other site 585035004562 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 585035004563 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 585035004564 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 585035004565 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585035004566 putative active site [active] 585035004567 heme pocket [chemical binding]; other site 585035004568 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585035004569 putative active site [active] 585035004570 heme pocket [chemical binding]; other site 585035004571 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585035004572 metal binding site [ion binding]; metal-binding site 585035004573 active site 585035004574 I-site; other site 585035004575 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585035004576 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585035004577 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585035004578 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 585035004579 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 585035004580 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 585035004581 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 585035004582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035004583 catalytic residue [active] 585035004584 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 585035004585 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 585035004586 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 585035004587 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 585035004588 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 585035004589 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 585035004590 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 585035004591 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 585035004592 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 585035004593 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 585035004594 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 585035004595 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585035004596 FeS/SAM binding site; other site 585035004597 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 585035004598 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 585035004599 Sulfatase; Region: Sulfatase; pfam00884 585035004600 transcriptional regulator YdeO; Provisional; Region: PRK09940 585035004601 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035004602 putative oxidoreductase; Provisional; Region: PRK09939 585035004603 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 585035004604 putative molybdopterin cofactor binding site [chemical binding]; other site 585035004605 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 585035004606 putative molybdopterin cofactor binding site; other site 585035004607 Evidence 7 : Gene remnant; Product type ps : structure 585035004608 Fimbrial protein; Region: Fimbrial; cl01416 585035004609 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 585035004610 NAD(P) binding site [chemical binding]; other site 585035004611 HipA N-terminal domain; Region: Couple_hipA; pfam13657 585035004612 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 585035004613 HipA-like N-terminal domain; Region: HipA_N; pfam07805 585035004614 HipA-like C-terminal domain; Region: HipA_C; pfam07804 585035004615 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 585035004616 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585035004617 non-specific DNA binding site [nucleotide binding]; other site 585035004618 salt bridge; other site 585035004619 sequence-specific DNA binding site [nucleotide binding]; other site 585035004620 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 585035004621 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035004622 S-adenosylmethionine binding site [chemical binding]; other site 585035004623 Predicted membrane protein [Function unknown]; Region: COG3781 585035004624 altronate oxidoreductase; Provisional; Region: PRK03643 585035004625 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 585035004626 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 585035004627 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585035004628 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585035004629 metal binding site [ion binding]; metal-binding site 585035004630 active site 585035004631 I-site; other site 585035004632 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 585035004633 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 585035004634 glutaminase; Provisional; Region: PRK00971 585035004635 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 585035004636 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 585035004637 NAD(P) binding site [chemical binding]; other site 585035004638 catalytic residues [active] 585035004639 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585035004640 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035004641 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 585035004642 putative dimerization interface [polypeptide binding]; other site 585035004643 putative arabinose transporter; Provisional; Region: PRK03545 585035004644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035004645 putative substrate translocation pore; other site 585035004646 inner membrane protein; Provisional; Region: PRK10995 585035004647 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 585035004648 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 585035004649 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 585035004650 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035004651 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035004652 hypothetical protein; Provisional; Region: PRK10106 585035004653 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 585035004654 beta-galactosidase; Region: BGL; TIGR03356 585035004655 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 585035004656 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 585035004657 trimer interface; other site 585035004658 sugar binding site [chemical binding]; other site 585035004659 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 585035004660 active site 585035004661 methionine cluster; other site 585035004662 phosphorylation site [posttranslational modification] 585035004663 metal binding site [ion binding]; metal-binding site 585035004664 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 585035004665 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 585035004666 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 585035004667 active site 585035004668 P-loop; other site 585035004669 phosphorylation site [posttranslational modification] 585035004670 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 585035004671 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585035004672 DNA-binding site [nucleotide binding]; DNA binding site 585035004673 UTRA domain; Region: UTRA; pfam07702 585035004674 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 585035004675 EamA-like transporter family; Region: EamA; pfam00892 585035004676 EamA-like transporter family; Region: EamA; pfam00892 585035004677 putative transporter; Provisional; Region: PRK10054 585035004678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035004679 putative substrate translocation pore; other site 585035004680 diguanylate cyclase; Provisional; Region: PRK09894 585035004681 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 585035004682 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585035004683 metal binding site [ion binding]; metal-binding site 585035004684 active site 585035004685 I-site; other site 585035004686 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 585035004687 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 585035004688 active site 585035004689 Zn binding site [ion binding]; other site 585035004690 malonic semialdehyde reductase; Provisional; Region: PRK10538 585035004691 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 585035004692 putative NAD(P) binding site [chemical binding]; other site 585035004693 homodimer interface [polypeptide binding]; other site 585035004694 homotetramer interface [polypeptide binding]; other site 585035004695 active site 585035004696 Transcriptional regulators [Transcription]; Region: GntR; COG1802 585035004697 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585035004698 DNA-binding site [nucleotide binding]; DNA binding site 585035004699 FCD domain; Region: FCD; pfam07729 585035004700 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 585035004701 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 585035004702 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 585035004703 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 585035004704 Evidence 7 : Gene remnant; Product type pt : transporter 585035004705 putative oxidoreductase; Provisional; Region: PRK10083 585035004706 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 585035004707 putative NAD(P) binding site [chemical binding]; other site 585035004708 catalytic Zn binding site [ion binding]; other site 585035004709 structural Zn binding site [ion binding]; other site 585035004710 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 585035004711 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 585035004712 putative active site pocket [active] 585035004713 putative metal binding site [ion binding]; other site 585035004714 hypothetical protein; Provisional; Region: PRK02237 585035004715 hypothetical protein; Provisional; Region: PRK13659 585035004716 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 585035004717 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585035004718 Coenzyme A binding pocket [chemical binding]; other site 585035004719 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 585035004720 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 585035004721 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 585035004722 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 585035004723 putative [Fe4-S4] binding site [ion binding]; other site 585035004724 putative molybdopterin cofactor binding site [chemical binding]; other site 585035004725 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 585035004726 putative molybdopterin cofactor binding site; other site 585035004727 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 585035004728 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 585035004729 putative [Fe4-S4] binding site [ion binding]; other site 585035004730 putative molybdopterin cofactor binding site [chemical binding]; other site 585035004731 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 585035004732 putative molybdopterin cofactor binding site; other site 585035004733 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 585035004734 4Fe-4S binding domain; Region: Fer4; cl02805 585035004735 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 585035004736 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 585035004737 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 585035004738 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 585035004739 Cl- selectivity filter; other site 585035004740 Cl- binding residues [ion binding]; other site 585035004741 pore gating glutamate residue; other site 585035004742 dimer interface [polypeptide binding]; other site 585035004743 putative dithiobiotin synthetase; Provisional; Region: PRK12374 585035004744 AAA domain; Region: AAA_26; pfam13500 585035004745 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 585035004746 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 585035004747 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585035004748 nucleotide binding site [chemical binding]; other site 585035004749 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 585035004750 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035004751 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 585035004752 dimerization interface [polypeptide binding]; other site 585035004753 substrate binding pocket [chemical binding]; other site 585035004754 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 585035004755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035004756 putative substrate translocation pore; other site 585035004757 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 585035004758 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 585035004759 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 585035004760 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 585035004761 Domain of unknown function DUF20; Region: UPF0118; pfam01594 585035004762 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 585035004763 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 585035004764 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 585035004765 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 585035004766 ligand binding site [chemical binding]; other site 585035004767 homodimer interface [polypeptide binding]; other site 585035004768 NAD(P) binding site [chemical binding]; other site 585035004769 trimer interface B [polypeptide binding]; other site 585035004770 trimer interface A [polypeptide binding]; other site 585035004771 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 585035004772 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585035004773 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585035004774 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585035004775 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 585035004776 Spore germination protein; Region: Spore_permease; cl17796 585035004777 dihydromonapterin reductase; Provisional; Region: PRK06483 585035004778 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 585035004779 NADP binding site [chemical binding]; other site 585035004780 substrate binding pocket [chemical binding]; other site 585035004781 active site 585035004782 GlpM protein; Region: GlpM; pfam06942 585035004783 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 585035004784 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035004785 active site 585035004786 phosphorylation site [posttranslational modification] 585035004787 intermolecular recognition site; other site 585035004788 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585035004789 DNA binding site [nucleotide binding] 585035004790 sensor protein RstB; Provisional; Region: PRK10604 585035004791 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585035004792 dimerization interface [polypeptide binding]; other site 585035004793 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585035004794 dimer interface [polypeptide binding]; other site 585035004795 phosphorylation site [posttranslational modification] 585035004796 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035004797 ATP binding site [chemical binding]; other site 585035004798 Mg2+ binding site [ion binding]; other site 585035004799 G-X-G motif; other site 585035004800 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 585035004801 fumarate hydratase; Reviewed; Region: fumC; PRK00485 585035004802 Class II fumarases; Region: Fumarase_classII; cd01362 585035004803 active site 585035004804 tetramer interface [polypeptide binding]; other site 585035004805 fumarate hydratase; Provisional; Region: PRK15389 585035004806 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 585035004807 Fumarase C-terminus; Region: Fumerase_C; pfam05683 585035004808 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 585035004809 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 585035004810 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 585035004811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 585035004812 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 585035004813 putative outer membrane porin protein; Provisional; Region: PRK11379 585035004814 glucuronide transporter; Provisional; Region: PRK09848 585035004815 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 585035004816 beta-D-glucuronidase; Provisional; Region: PRK10150 585035004817 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 585035004818 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 585035004819 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 585035004820 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 585035004821 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585035004822 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 585035004823 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 585035004824 NAD binding site [chemical binding]; other site 585035004825 substrate binding site [chemical binding]; other site 585035004826 homotetramer interface [polypeptide binding]; other site 585035004827 homodimer interface [polypeptide binding]; other site 585035004828 active site 585035004829 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 585035004830 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585035004831 DNA binding site [nucleotide binding] 585035004832 domain linker motif; other site 585035004833 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 585035004834 putative dimerization interface [polypeptide binding]; other site 585035004835 putative ligand binding site [chemical binding]; other site 585035004836 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 585035004837 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 585035004838 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585035004839 active site turn [active] 585035004840 phosphorylation site [posttranslational modification] 585035004841 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 585035004842 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585035004843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035004844 homodimer interface [polypeptide binding]; other site 585035004845 catalytic residue [active] 585035004846 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 585035004847 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 585035004848 active site 585035004849 purine riboside binding site [chemical binding]; other site 585035004850 putative oxidoreductase; Provisional; Region: PRK11579 585035004851 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 585035004852 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 585035004853 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 585035004854 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 585035004855 electron transport complex protein RsxA; Provisional; Region: PRK05151 585035004856 electron transport complex protein RnfB; Provisional; Region: PRK05113 585035004857 Putative Fe-S cluster; Region: FeS; pfam04060 585035004858 4Fe-4S binding domain; Region: Fer4; pfam00037 585035004859 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 585035004860 SLBB domain; Region: SLBB; pfam10531 585035004861 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585035004862 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 585035004863 electron transport complex protein RnfG; Validated; Region: PRK01908 585035004864 electron transport complex RsxE subunit; Provisional; Region: PRK12405 585035004865 endonuclease III; Provisional; Region: PRK10702 585035004866 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 585035004867 minor groove reading motif; other site 585035004868 helix-hairpin-helix signature motif; other site 585035004869 substrate binding pocket [chemical binding]; other site 585035004870 active site 585035004871 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 585035004872 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 585035004873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035004874 putative substrate translocation pore; other site 585035004875 POT family; Region: PTR2; pfam00854 585035004876 glutathionine S-transferase; Provisional; Region: PRK10542 585035004877 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 585035004878 C-terminal domain interface [polypeptide binding]; other site 585035004879 GSH binding site (G-site) [chemical binding]; other site 585035004880 dimer interface [polypeptide binding]; other site 585035004881 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 585035004882 N-terminal domain interface [polypeptide binding]; other site 585035004883 dimer interface [polypeptide binding]; other site 585035004884 substrate binding pocket (H-site) [chemical binding]; other site 585035004885 pyridoxamine kinase; Validated; Region: PRK05756 585035004886 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 585035004887 dimer interface [polypeptide binding]; other site 585035004888 pyridoxal binding site [chemical binding]; other site 585035004889 ATP binding site [chemical binding]; other site 585035004890 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 585035004891 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 585035004892 active site 585035004893 HIGH motif; other site 585035004894 dimer interface [polypeptide binding]; other site 585035004895 KMSKS motif; other site 585035004896 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585035004897 RNA binding surface [nucleotide binding]; other site 585035004898 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 585035004899 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 585035004900 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 585035004901 lysozyme inhibitor; Provisional; Region: PRK11372 585035004902 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 585035004903 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 585035004904 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 585035004905 transcriptional regulator SlyA; Provisional; Region: PRK03573 585035004906 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 585035004907 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 585035004908 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 585035004909 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585035004910 HlyD family secretion protein; Region: HlyD_3; pfam13437 585035004911 Fusaric acid resistance protein family; Region: FUSC; pfam04632 585035004912 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 585035004913 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 585035004914 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 585035004915 E-class dimer interface [polypeptide binding]; other site 585035004916 P-class dimer interface [polypeptide binding]; other site 585035004917 active site 585035004918 Cu2+ binding site [ion binding]; other site 585035004919 Zn2+ binding site [ion binding]; other site 585035004920 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585035004921 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585035004922 active site 585035004923 catalytic tetrad [active] 585035004924 Predicted Fe-S protein [General function prediction only]; Region: COG3313 585035004925 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 585035004926 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585035004927 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 585035004928 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 585035004929 FMN binding site [chemical binding]; other site 585035004930 active site 585035004931 substrate binding site [chemical binding]; other site 585035004932 catalytic residue [active] 585035004933 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 585035004934 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 585035004935 dimer interface [polypeptide binding]; other site 585035004936 active site 585035004937 metal binding site [ion binding]; metal-binding site 585035004938 glutathione binding site [chemical binding]; other site 585035004939 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 585035004940 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 585035004941 dimer interface [polypeptide binding]; other site 585035004942 catalytic site [active] 585035004943 putative active site [active] 585035004944 putative substrate binding site [chemical binding]; other site 585035004945 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 585035004946 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 585035004947 putative GSH binding site [chemical binding]; other site 585035004948 catalytic residues [active] 585035004949 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585035004950 NlpC/P60 family; Region: NLPC_P60; pfam00877 585035004951 superoxide dismutase; Provisional; Region: PRK10543 585035004952 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 585035004953 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 585035004954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035004955 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585035004956 putative substrate translocation pore; other site 585035004957 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 585035004958 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585035004959 DNA binding site [nucleotide binding] 585035004960 domain linker motif; other site 585035004961 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 585035004962 dimerization interface [polypeptide binding]; other site 585035004963 ligand binding site [chemical binding]; other site 585035004964 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 585035004965 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035004966 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585035004967 dimerization interface [polypeptide binding]; other site 585035004968 putative transporter; Provisional; Region: PRK11043 585035004969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035004970 putative substrate translocation pore; other site 585035004971 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 585035004972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 585035004973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035004974 S-adenosylmethionine binding site [chemical binding]; other site 585035004975 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 585035004976 Lumazine binding domain; Region: Lum_binding; pfam00677 585035004977 Lumazine binding domain; Region: Lum_binding; pfam00677 585035004978 multidrug efflux protein; Reviewed; Region: PRK01766 585035004979 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 585035004980 cation binding site [ion binding]; other site 585035004981 hypothetical protein; Provisional; Region: PRK09945 585035004982 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 585035004983 putative monooxygenase; Provisional; Region: PRK11118 585035004984 hypothetical protein; Provisional; Region: PRK09897 585035004985 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 585035004986 hypothetical protein; Provisional; Region: PRK09946 585035004987 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 585035004988 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 585035004989 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 585035004990 hypothetical protein; Provisional; Region: PRK09947 585035004991 putative oxidoreductase; Provisional; Region: PRK09849 585035004992 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 585035004993 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 585035004994 hypothetical protein; Provisional; Region: PRK09898 585035004995 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585035004996 hypothetical protein; Provisional; Region: PRK10292 585035004997 pyruvate kinase; Provisional; Region: PRK09206 585035004998 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 585035004999 domain interfaces; other site 585035005000 active site 585035005001 murein lipoprotein; Provisional; Region: PRK15396 585035005002 L,D-transpeptidase; Provisional; Region: PRK10190 585035005003 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585035005004 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585035005005 cysteine desufuration protein SufE; Provisional; Region: PRK09296 585035005006 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 585035005007 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 585035005008 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585035005009 catalytic residue [active] 585035005010 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 585035005011 FeS assembly protein SufD; Region: sufD; TIGR01981 585035005012 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 585035005013 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 585035005014 Walker A/P-loop; other site 585035005015 ATP binding site [chemical binding]; other site 585035005016 Q-loop/lid; other site 585035005017 ABC transporter signature motif; other site 585035005018 Walker B; other site 585035005019 D-loop; other site 585035005020 H-loop/switch region; other site 585035005021 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 585035005022 putative ABC transporter; Region: ycf24; CHL00085 585035005023 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 585035005024 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 585035005025 CoenzymeA binding site [chemical binding]; other site 585035005026 subunit interaction site [polypeptide binding]; other site 585035005027 PHB binding site; other site 585035005028 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 585035005029 FAD binding domain; Region: FAD_binding_4; pfam01565 585035005030 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 585035005031 putative inner membrane protein; Provisional; Region: PRK10983 585035005032 Domain of unknown function DUF20; Region: UPF0118; pfam01594 585035005033 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 585035005034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035005035 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585035005036 putative substrate translocation pore; other site 585035005037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035005038 putative substrate translocation pore; other site 585035005039 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 585035005040 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 585035005041 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 585035005042 shikimate binding site; other site 585035005043 NAD(P) binding site [chemical binding]; other site 585035005044 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 585035005045 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 585035005046 active site 585035005047 catalytic residue [active] 585035005048 dimer interface [polypeptide binding]; other site 585035005049 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 585035005050 Coenzyme A transferase; Region: CoA_trans; smart00882 585035005051 Coenzyme A transferase; Region: CoA_trans; cl17247 585035005052 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 585035005053 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 585035005054 active site 585035005055 Cupin domain; Region: Cupin_2; pfam07883 585035005056 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 585035005057 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585035005058 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035005059 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 585035005060 Ligand binding site [chemical binding]; other site 585035005061 Electron transfer flavoprotein domain; Region: ETF; pfam01012 585035005062 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 585035005063 Electron transfer flavoprotein domain; Region: ETF; smart00893 585035005064 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 585035005065 oxidoreductase; Provisional; Region: PRK10015 585035005066 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 585035005067 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 585035005068 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 585035005069 acyl-activating enzyme (AAE) consensus motif; other site 585035005070 putative AMP binding site [chemical binding]; other site 585035005071 putative active site [active] 585035005072 putative CoA binding site [chemical binding]; other site 585035005073 phosphoenolpyruvate synthase; Validated; Region: PRK06464 585035005074 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 585035005075 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 585035005076 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 585035005077 PEP synthetase regulatory protein; Provisional; Region: PRK05339 585035005078 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 585035005079 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 585035005080 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 585035005081 Uncharacterized conserved protein [Function unknown]; Region: COG0397 585035005082 hypothetical protein; Validated; Region: PRK00029 585035005083 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 585035005084 NlpC/P60 family; Region: NLPC_P60; pfam00877 585035005085 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 585035005086 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 585035005087 Walker A/P-loop; other site 585035005088 ATP binding site [chemical binding]; other site 585035005089 Q-loop/lid; other site 585035005090 ABC transporter signature motif; other site 585035005091 Walker B; other site 585035005092 D-loop; other site 585035005093 H-loop/switch region; other site 585035005094 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 585035005095 catalytic residues [active] 585035005096 dimer interface [polypeptide binding]; other site 585035005097 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 585035005098 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585035005099 ABC-ATPase subunit interface; other site 585035005100 dimer interface [polypeptide binding]; other site 585035005101 putative PBP binding regions; other site 585035005102 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 585035005103 IHF dimer interface [polypeptide binding]; other site 585035005104 IHF - DNA interface [nucleotide binding]; other site 585035005105 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 585035005106 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 585035005107 putative tRNA-binding site [nucleotide binding]; other site 585035005108 B3/4 domain; Region: B3_4; pfam03483 585035005109 tRNA synthetase B5 domain; Region: B5; smart00874 585035005110 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 585035005111 dimer interface [polypeptide binding]; other site 585035005112 motif 1; other site 585035005113 motif 3; other site 585035005114 motif 2; other site 585035005115 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 585035005116 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 585035005117 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 585035005118 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 585035005119 dimer interface [polypeptide binding]; other site 585035005120 motif 1; other site 585035005121 active site 585035005122 motif 2; other site 585035005123 motif 3; other site 585035005124 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 585035005125 23S rRNA binding site [nucleotide binding]; other site 585035005126 L21 binding site [polypeptide binding]; other site 585035005127 L13 binding site [polypeptide binding]; other site 585035005128 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 585035005129 Evidence 7 : Gene remnant; Product type f : factor 585035005130 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 585035005131 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 585035005132 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 585035005133 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 585035005134 active site 585035005135 dimer interface [polypeptide binding]; other site 585035005136 motif 1; other site 585035005137 motif 2; other site 585035005138 motif 3; other site 585035005139 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 585035005140 anticodon binding site; other site 585035005141 Evidence 7 : Gene remnant; Product type pr : regulator 585035005142 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 585035005143 Evidence 7 : Gene remnant; Product type pr : regulator 585035005144 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 585035005145 6-phosphofructokinase 2; Provisional; Region: PRK10294 585035005146 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 585035005147 putative substrate binding site [chemical binding]; other site 585035005148 putative ATP binding site [chemical binding]; other site 585035005149 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 585035005150 Phosphotransferase enzyme family; Region: APH; pfam01636 585035005151 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 585035005152 active site 585035005153 ATP binding site [chemical binding]; other site 585035005154 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 585035005155 YniB-like protein; Region: YniB; pfam14002 585035005156 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 585035005157 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 585035005158 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585035005159 motif II; other site 585035005160 inner membrane protein; Provisional; Region: PRK11648 585035005161 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 585035005162 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 585035005163 cell division modulator; Provisional; Region: PRK10113 585035005164 hydroperoxidase II; Provisional; Region: katE; PRK11249 585035005165 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 585035005166 tetramer interface [polypeptide binding]; other site 585035005167 heme binding pocket [chemical binding]; other site 585035005168 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 585035005169 domain interactions; other site 585035005170 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 585035005171 putative active site [active] 585035005172 YdjC motif; other site 585035005173 Mg binding site [ion binding]; other site 585035005174 putative homodimer interface [polypeptide binding]; other site 585035005175 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 585035005176 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 585035005177 NAD binding site [chemical binding]; other site 585035005178 sugar binding site [chemical binding]; other site 585035005179 divalent metal binding site [ion binding]; other site 585035005180 tetramer (dimer of dimers) interface [polypeptide binding]; other site 585035005181 dimer interface [polypeptide binding]; other site 585035005182 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 585035005183 Cupin domain; Region: Cupin_2; pfam07883 585035005184 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035005185 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 585035005186 methionine cluster; other site 585035005187 active site 585035005188 phosphorylation site [posttranslational modification] 585035005189 metal binding site [ion binding]; metal-binding site 585035005190 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 585035005191 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 585035005192 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 585035005193 active site 585035005194 P-loop; other site 585035005195 phosphorylation site [posttranslational modification] 585035005196 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 585035005197 NAD+ synthetase; Region: nadE; TIGR00552 585035005198 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 585035005199 homodimer interface [polypeptide binding]; other site 585035005200 NAD binding pocket [chemical binding]; other site 585035005201 ATP binding pocket [chemical binding]; other site 585035005202 Mg binding site [ion binding]; other site 585035005203 active-site loop [active] 585035005204 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 585035005205 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 585035005206 GIY-YIG motif/motif A; other site 585035005207 active site 585035005208 catalytic site [active] 585035005209 putative DNA binding site [nucleotide binding]; other site 585035005210 metal binding site [ion binding]; metal-binding site 585035005211 hypothetical protein; Provisional; Region: PRK11396 585035005212 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 585035005213 dimer interface [polypeptide binding]; other site 585035005214 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 585035005215 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 585035005216 putative active site [active] 585035005217 Zn binding site [ion binding]; other site 585035005218 succinylarginine dihydrolase; Provisional; Region: PRK13281 585035005219 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 585035005220 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 585035005221 NAD(P) binding site [chemical binding]; other site 585035005222 catalytic residues [active] 585035005223 arginine succinyltransferase; Provisional; Region: PRK10456 585035005224 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 585035005225 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 585035005226 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585035005227 inhibitor-cofactor binding pocket; inhibition site 585035005228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035005229 catalytic residue [active] 585035005230 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 585035005231 putative catalytic site [active] 585035005232 putative phosphate binding site [ion binding]; other site 585035005233 active site 585035005234 metal binding site A [ion binding]; metal-binding site 585035005235 DNA binding site [nucleotide binding] 585035005236 putative AP binding site [nucleotide binding]; other site 585035005237 putative metal binding site B [ion binding]; other site 585035005238 Uncharacterized conserved protein [Function unknown]; Region: COG0398 585035005239 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 585035005240 Uncharacterized conserved protein [Function unknown]; Region: COG0398 585035005241 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 585035005242 Uncharacterized conserved protein [Function unknown]; Region: COG2128 585035005243 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 585035005244 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 585035005245 hypothetical protein; Provisional; Region: PRK11622 585035005246 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 585035005247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035005248 dimer interface [polypeptide binding]; other site 585035005249 conserved gate region; other site 585035005250 putative PBP binding loops; other site 585035005251 ABC-ATPase subunit interface; other site 585035005252 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 585035005253 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585035005254 Walker A/P-loop; other site 585035005255 ATP binding site [chemical binding]; other site 585035005256 Q-loop/lid; other site 585035005257 ABC transporter signature motif; other site 585035005258 Walker B; other site 585035005259 D-loop; other site 585035005260 H-loop/switch region; other site 585035005261 Rhodanese Homology Domain; Region: RHOD; smart00450 585035005262 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 585035005263 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 585035005264 active site residue [active] 585035005265 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 585035005266 active site residue [active] 585035005267 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 585035005268 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 585035005269 active site 585035005270 8-oxo-dGMP binding site [chemical binding]; other site 585035005271 nudix motif; other site 585035005272 metal binding site [ion binding]; metal-binding site 585035005273 glutamate dehydrogenase; Provisional; Region: PRK09414 585035005274 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 585035005275 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 585035005276 NAD(P) binding site [chemical binding]; other site 585035005277 DNA topoisomerase III; Provisional; Region: PRK07726 585035005278 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 585035005279 active site 585035005280 putative interdomain interaction site [polypeptide binding]; other site 585035005281 putative metal-binding site [ion binding]; other site 585035005282 putative nucleotide binding site [chemical binding]; other site 585035005283 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 585035005284 domain I; other site 585035005285 DNA binding groove [nucleotide binding] 585035005286 phosphate binding site [ion binding]; other site 585035005287 domain II; other site 585035005288 domain III; other site 585035005289 nucleotide binding site [chemical binding]; other site 585035005290 catalytic site [active] 585035005291 domain IV; other site 585035005292 selenophosphate synthetase; Provisional; Region: PRK00943 585035005293 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 585035005294 dimerization interface [polypeptide binding]; other site 585035005295 putative ATP binding site [chemical binding]; other site 585035005296 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 585035005297 putative FMN binding site [chemical binding]; other site 585035005298 protease 4; Provisional; Region: PRK10949 585035005299 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 585035005300 tandem repeat interface [polypeptide binding]; other site 585035005301 oligomer interface [polypeptide binding]; other site 585035005302 active site residues [active] 585035005303 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 585035005304 tandem repeat interface [polypeptide binding]; other site 585035005305 oligomer interface [polypeptide binding]; other site 585035005306 active site residues [active] 585035005307 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 585035005308 active site 585035005309 homodimer interface [polypeptide binding]; other site 585035005310 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 585035005311 Isochorismatase family; Region: Isochorismatase; pfam00857 585035005312 catalytic triad [active] 585035005313 metal binding site [ion binding]; metal-binding site 585035005314 conserved cis-peptide bond; other site 585035005315 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 585035005316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035005317 putative substrate translocation pore; other site 585035005318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035005319 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 585035005320 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 585035005321 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585035005322 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585035005323 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585035005324 active site 585035005325 catalytic tetrad [active] 585035005326 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585035005327 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 585035005328 substrate binding site [chemical binding]; other site 585035005329 ATP binding site [chemical binding]; other site 585035005330 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 585035005331 intersubunit interface [polypeptide binding]; other site 585035005332 active site 585035005333 zinc binding site [ion binding]; other site 585035005334 Na+ binding site [ion binding]; other site 585035005335 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 585035005336 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 585035005337 inhibitor binding site; inhibition site 585035005338 catalytic Zn binding site [ion binding]; other site 585035005339 structural Zn binding site [ion binding]; other site 585035005340 NADP binding site [chemical binding]; other site 585035005341 tetramer interface [polypeptide binding]; other site 585035005342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035005343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035005344 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 585035005345 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 585035005346 putative NAD(P) binding site [chemical binding]; other site 585035005347 catalytic Zn binding site [ion binding]; other site 585035005348 structural Zn binding site [ion binding]; other site 585035005349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 585035005350 methionine sulfoxide reductase B; Provisional; Region: PRK00222 585035005351 SelR domain; Region: SelR; pfam01641 585035005352 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 585035005353 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 585035005354 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 585035005355 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 585035005356 active site 585035005357 phosphate binding residues; other site 585035005358 catalytic residues [active] 585035005359 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585035005360 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585035005361 active site 585035005362 catalytic tetrad [active] 585035005363 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 585035005364 PrkA family serine protein kinase; Provisional; Region: PRK15455 585035005365 AAA ATPase domain; Region: AAA_16; pfam13191 585035005366 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 585035005367 hypothetical protein; Provisional; Region: PRK05325 585035005368 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585035005369 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585035005370 metal binding site [ion binding]; metal-binding site 585035005371 active site 585035005372 I-site; other site 585035005373 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme 585035005374 Evidence 7 : Gene remnant; Product type pe : enzyme 585035005375 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 585035005376 putative deacylase active site [active] 585035005377 Predicted membrane protein [Function unknown]; Region: COG2707 585035005378 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585035005379 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035005380 cyanate transporter; Region: CynX; TIGR00896 585035005381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035005382 Uncharacterized conserved protein [Function unknown]; Region: COG3189 585035005383 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 585035005384 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 585035005385 Domain of unknown function (DUF333); Region: DUF333; pfam03891 585035005386 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 585035005387 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 585035005388 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585035005389 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585035005390 metal binding site [ion binding]; metal-binding site 585035005391 active site 585035005392 I-site; other site 585035005393 hypothetical protein; Provisional; Region: PRK10457 585035005394 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 585035005395 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 585035005396 leucine export protein LeuE; Provisional; Region: PRK10958 585035005397 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator 585035005398 Evidence 7 : Gene remnant; Product type pe : enzyme 585035005399 ribonuclease D; Provisional; Region: PRK10829 585035005400 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 585035005401 catalytic site [active] 585035005402 putative active site [active] 585035005403 putative substrate binding site [chemical binding]; other site 585035005404 Helicase and RNase D C-terminal; Region: HRDC; smart00341 585035005405 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 585035005406 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 585035005407 acyl-activating enzyme (AAE) consensus motif; other site 585035005408 putative AMP binding site [chemical binding]; other site 585035005409 putative active site [active] 585035005410 putative CoA binding site [chemical binding]; other site 585035005411 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 585035005412 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 585035005413 Glycoprotease family; Region: Peptidase_M22; pfam00814 585035005414 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 585035005415 DEAD/DEAH box helicase; Region: DEAD; pfam00270 585035005416 DEAD_2; Region: DEAD_2; pfam06733 585035005417 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 585035005418 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 585035005419 homotrimer interaction site [polypeptide binding]; other site 585035005420 putative active site [active] 585035005421 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 585035005422 hypothetical protein; Provisional; Region: PRK05114 585035005423 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 585035005424 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 585035005425 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 585035005426 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 585035005427 putative active site [active] 585035005428 putative CoA binding site [chemical binding]; other site 585035005429 nudix motif; other site 585035005430 metal binding site [ion binding]; metal-binding site 585035005431 L-serine deaminase; Provisional; Region: PRK15023 585035005432 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 585035005433 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 585035005434 phage resistance protein; Provisional; Region: PRK10551 585035005435 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 585035005436 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585035005437 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 585035005438 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 585035005439 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 585035005440 Transporter associated domain; Region: CorC_HlyC; smart01091 585035005441 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 585035005442 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 585035005443 active pocket/dimerization site; other site 585035005444 active site 585035005445 phosphorylation site [posttranslational modification] 585035005446 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 585035005447 active site 585035005448 phosphorylation site [posttranslational modification] 585035005449 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 585035005450 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 585035005451 Predicted membrane protein [Function unknown]; Region: COG4811 585035005452 hypothetical protein; Provisional; Region: PRK11469 585035005453 Domain of unknown function DUF; Region: DUF204; pfam02659 585035005454 Domain of unknown function DUF; Region: DUF204; pfam02659 585035005455 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 585035005456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035005457 S-adenosylmethionine binding site [chemical binding]; other site 585035005458 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585035005459 DNA-binding site [nucleotide binding]; DNA binding site 585035005460 RNA-binding motif; other site 585035005461 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 585035005462 YebO-like protein; Region: YebO; pfam13974 585035005463 PhoPQ regulatory protein; Provisional; Region: PRK10299 585035005464 YobH-like protein; Region: YobH; pfam13996 585035005465 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 585035005466 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585035005467 dimerization interface [polypeptide binding]; other site 585035005468 putative Zn2+ binding site [ion binding]; other site 585035005469 putative DNA binding site [nucleotide binding]; other site 585035005470 Bacterial transcriptional regulator; Region: IclR; pfam01614 585035005471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035005472 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585035005473 putative substrate translocation pore; other site 585035005474 Predicted integral membrane protein [Function unknown]; Region: COG5521 585035005475 heat shock protein HtpX; Provisional; Region: PRK05457 585035005476 carboxy-terminal protease; Provisional; Region: PRK11186 585035005477 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 585035005478 protein binding site [polypeptide binding]; other site 585035005479 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 585035005480 Catalytic dyad [active] 585035005481 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 585035005482 ProP expression regulator; Provisional; Region: PRK04950 585035005483 ProQ/FINO family; Region: ProQ; pfam04352 585035005484 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 585035005485 GAF domain; Region: GAF_2; pfam13185 585035005486 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 585035005487 Paraquat-inducible protein A; Region: PqiA; pfam04403 585035005488 Paraquat-inducible protein A; Region: PqiA; pfam04403 585035005489 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 585035005490 mce related protein; Region: MCE; pfam02470 585035005491 mce related protein; Region: MCE; pfam02470 585035005492 mce related protein; Region: MCE; pfam02470 585035005493 mce related protein; Region: MCE; pfam02470 585035005494 mce related protein; Region: MCE; pfam02470 585035005495 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 585035005496 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 585035005497 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 585035005498 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 585035005499 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 585035005500 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 585035005501 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 585035005502 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 585035005503 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 585035005504 hypothetical protein; Provisional; Region: PRK10301 585035005505 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 585035005506 Predicted amidohydrolase [General function prediction only]; Region: COG0388 585035005507 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 585035005508 exodeoxyribonuclease X; Provisional; Region: PRK07983 585035005509 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 585035005510 active site 585035005511 catalytic site [active] 585035005512 substrate binding site [chemical binding]; other site 585035005513 protease 2; Provisional; Region: PRK10115 585035005514 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 585035005515 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 585035005516 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 585035005517 putative metal binding site [ion binding]; other site 585035005518 hypothetical protein; Provisional; Region: PRK13680 585035005519 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 585035005520 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 585035005521 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 585035005522 ATP-grasp domain; Region: ATP-grasp; pfam02222 585035005523 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 585035005524 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 585035005525 active site 585035005526 intersubunit interface [polypeptide binding]; other site 585035005527 catalytic residue [active] 585035005528 phosphogluconate dehydratase; Validated; Region: PRK09054 585035005529 6-phosphogluconate dehydratase; Region: edd; TIGR01196 585035005530 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 585035005531 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 585035005532 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 585035005533 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 585035005534 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 585035005535 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 585035005536 putative active site [active] 585035005537 pyruvate kinase; Provisional; Region: PRK05826 585035005538 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 585035005539 domain interfaces; other site 585035005540 active site 585035005541 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 585035005542 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 585035005543 putative acyl-acceptor binding pocket; other site 585035005544 putative peptidase; Provisional; Region: PRK11649 585035005545 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 585035005546 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585035005547 Peptidase family M23; Region: Peptidase_M23; pfam01551 585035005548 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 585035005549 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 585035005550 metal binding site [ion binding]; metal-binding site 585035005551 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 585035005552 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 585035005553 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 585035005554 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585035005555 ABC-ATPase subunit interface; other site 585035005556 dimer interface [polypeptide binding]; other site 585035005557 putative PBP binding regions; other site 585035005558 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 585035005559 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035005560 Walker A motif; other site 585035005561 ATP binding site [chemical binding]; other site 585035005562 Walker B motif; other site 585035005563 arginine finger; other site 585035005564 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 585035005565 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 585035005566 RuvA N terminal domain; Region: RuvA_N; pfam01330 585035005567 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 585035005568 hypothetical protein; Provisional; Region: PRK11470 585035005569 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 585035005570 active site 585035005571 putative DNA-binding cleft [nucleotide binding]; other site 585035005572 dimer interface [polypeptide binding]; other site 585035005573 hypothetical protein; Validated; Region: PRK00110 585035005574 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 585035005575 nudix motif; other site 585035005576 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 585035005577 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 585035005578 dimer interface [polypeptide binding]; other site 585035005579 anticodon binding site; other site 585035005580 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 585035005581 homodimer interface [polypeptide binding]; other site 585035005582 motif 1; other site 585035005583 active site 585035005584 motif 2; other site 585035005585 GAD domain; Region: GAD; pfam02938 585035005586 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 585035005587 motif 3; other site 585035005588 Isochorismatase family; Region: Isochorismatase; pfam00857 585035005589 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 585035005590 catalytic triad [active] 585035005591 conserved cis-peptide bond; other site 585035005592 hypothetical protein; Provisional; Region: PRK10302 585035005593 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 585035005594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035005595 S-adenosylmethionine binding site [chemical binding]; other site 585035005596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035005597 S-adenosylmethionine binding site [chemical binding]; other site 585035005598 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 585035005599 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 585035005600 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 585035005601 molybdopterin cofactor binding site [chemical binding]; other site 585035005602 substrate binding site [chemical binding]; other site 585035005603 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 585035005604 molybdopterin cofactor binding site; other site 585035005605 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 585035005606 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 585035005607 copper homeostasis protein CutC; Provisional; Region: PRK11572 585035005608 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 585035005609 putative metal binding site [ion binding]; other site 585035005610 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 585035005611 arginyl-tRNA synthetase; Region: argS; TIGR00456 585035005612 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 585035005613 active site 585035005614 HIGH motif; other site 585035005615 KMSK motif region; other site 585035005616 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 585035005617 tRNA binding surface [nucleotide binding]; other site 585035005618 anticodon binding site; other site 585035005619 Flagellar protein FlhE; Region: FlhE; pfam06366 585035005620 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 585035005621 FHIPEP family; Region: FHIPEP; pfam00771 585035005622 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 585035005623 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 585035005624 chemotaxis regulator CheZ; Provisional; Region: PRK11166 585035005625 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 585035005626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035005627 active site 585035005628 phosphorylation site [posttranslational modification] 585035005629 intermolecular recognition site; other site 585035005630 dimerization interface [polypeptide binding]; other site 585035005631 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 585035005632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035005633 active site 585035005634 phosphorylation site [posttranslational modification] 585035005635 intermolecular recognition site; other site 585035005636 dimerization interface [polypeptide binding]; other site 585035005637 CheB methylesterase; Region: CheB_methylest; pfam01339 585035005638 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 585035005639 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 585035005640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035005641 S-adenosylmethionine binding site [chemical binding]; other site 585035005642 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 585035005643 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 585035005644 dimer interface [polypeptide binding]; other site 585035005645 ligand binding site [chemical binding]; other site 585035005646 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585035005647 dimerization interface [polypeptide binding]; other site 585035005648 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 585035005649 dimer interface [polypeptide binding]; other site 585035005650 putative CheW interface [polypeptide binding]; other site 585035005651 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 585035005652 putative CheA interaction surface; other site 585035005653 chemotaxis protein CheA; Provisional; Region: PRK10547 585035005654 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 585035005655 putative binding surface; other site 585035005656 active site 585035005657 CheY binding; Region: CheY-binding; pfam09078 585035005658 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 585035005659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035005660 ATP binding site [chemical binding]; other site 585035005661 Mg2+ binding site [ion binding]; other site 585035005662 G-X-G motif; other site 585035005663 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 585035005664 flagellar motor protein MotB; Validated; Region: motB; PRK09041 585035005665 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 585035005666 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585035005667 ligand binding site [chemical binding]; other site 585035005668 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 585035005669 flagellar motor protein MotA; Validated; Region: PRK09110 585035005670 transcriptional activator FlhC; Provisional; Region: PRK12722 585035005671 transcriptional activator FlhD; Provisional; Region: PRK02909 585035005672 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585035005673 Ligand Binding Site [chemical binding]; other site 585035005674 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 585035005675 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 585035005676 active site 585035005677 homotetramer interface [polypeptide binding]; other site 585035005678 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 585035005679 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 585035005680 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585035005681 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585035005682 TM-ABC transporter signature motif; other site 585035005683 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 585035005684 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585035005685 Walker A/P-loop; other site 585035005686 ATP binding site [chemical binding]; other site 585035005687 Q-loop/lid; other site 585035005688 ABC transporter signature motif; other site 585035005689 Walker B; other site 585035005690 D-loop; other site 585035005691 H-loop/switch region; other site 585035005692 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585035005693 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 585035005694 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 585035005695 ligand binding site [chemical binding]; other site 585035005696 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 585035005697 Ferritin-like domain; Region: Ferritin; pfam00210 585035005698 ferroxidase diiron center [ion binding]; other site 585035005699 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 585035005700 YecR-like lipoprotein; Region: YecR; pfam13992 585035005701 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 585035005702 Ferritin-like domain; Region: Ferritin; pfam00210 585035005703 ferroxidase diiron center [ion binding]; other site 585035005704 probable metal-binding protein; Region: matur_matur; TIGR03853 585035005705 tyrosine transporter TyrP; Provisional; Region: PRK15132 585035005706 aromatic amino acid transport protein; Region: araaP; TIGR00837 585035005707 hypothetical protein; Provisional; Region: PRK10396 585035005708 yecA family protein; Region: ygfB_yecA; TIGR02292 585035005709 SEC-C motif; Region: SEC-C; pfam02810 585035005710 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 585035005711 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 585035005712 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 585035005713 GIY-YIG motif/motif A; other site 585035005714 active site 585035005715 catalytic site [active] 585035005716 putative DNA binding site [nucleotide binding]; other site 585035005717 metal binding site [ion binding]; metal-binding site 585035005718 UvrB/uvrC motif; Region: UVR; pfam02151 585035005719 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 585035005720 Helix-hairpin-helix motif; Region: HHH; pfam00633 585035005721 response regulator; Provisional; Region: PRK09483 585035005722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035005723 active site 585035005724 phosphorylation site [posttranslational modification] 585035005725 intermolecular recognition site; other site 585035005726 dimerization interface [polypeptide binding]; other site 585035005727 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585035005728 DNA binding residues [nucleotide binding] 585035005729 dimerization interface [polypeptide binding]; other site 585035005730 hypothetical protein; Provisional; Region: PRK10613 585035005731 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 585035005732 Autoinducer binding domain; Region: Autoind_bind; pfam03472 585035005733 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585035005734 DNA binding residues [nucleotide binding] 585035005735 dimerization interface [polypeptide binding]; other site 585035005736 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 585035005737 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 585035005738 Walker A/P-loop; other site 585035005739 ATP binding site [chemical binding]; other site 585035005740 Q-loop/lid; other site 585035005741 ABC transporter signature motif; other site 585035005742 Walker B; other site 585035005743 D-loop; other site 585035005744 H-loop/switch region; other site 585035005745 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585035005746 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035005747 dimer interface [polypeptide binding]; other site 585035005748 conserved gate region; other site 585035005749 putative PBP binding loops; other site 585035005750 ABC-ATPase subunit interface; other site 585035005751 D-cysteine desulfhydrase; Validated; Region: PRK03910 585035005752 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 585035005753 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035005754 catalytic residue [active] 585035005755 cystine transporter subunit; Provisional; Region: PRK11260 585035005756 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585035005757 substrate binding pocket [chemical binding]; other site 585035005758 membrane-bound complex binding site; other site 585035005759 hinge residues; other site 585035005760 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 585035005761 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 585035005762 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 585035005763 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 585035005764 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585035005765 DNA binding residues [nucleotide binding] 585035005766 flagellin; Validated; Region: PRK08026 585035005767 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 585035005768 Flagellin protein; Region: FliC; pfam12445 585035005769 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 585035005770 flagellar capping protein; Reviewed; Region: fliD; PRK08032 585035005771 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 585035005772 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 585035005773 Flagellar protein FliS; Region: FliS; cl00654 585035005774 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 585035005775 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 585035005776 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 585035005777 active site 585035005778 Na/Ca binding site [ion binding]; other site 585035005779 catalytic site [active] 585035005780 lipoprotein; Provisional; Region: PRK10397 585035005781 putative inner membrane protein; Provisional; Region: PRK11099 585035005782 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 585035005783 CPxP motif; other site 585035005784 hypothetical protein; Provisional; Region: PRK09951 585035005785 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585035005786 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 585035005787 trimer interface [polypeptide binding]; other site 585035005788 eyelet of channel; other site 585035005789 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585035005790 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 585035005791 substrate binding site [chemical binding]; other site 585035005792 multidrug efflux protein; Reviewed; Region: emrE; PRK09541 585035005793 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 585035005794 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 585035005795 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 585035005796 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 585035005797 flagellar motor switch protein FliG; Region: fliG; TIGR00207 585035005798 FliG C-terminal domain; Region: FliG_C; pfam01706 585035005799 flagellar assembly protein H; Validated; Region: fliH; PRK05687 585035005800 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 585035005801 Flagellar assembly protein FliH; Region: FliH; pfam02108 585035005802 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 585035005803 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 585035005804 Walker A motif/ATP binding site; other site 585035005805 Walker B motif; other site 585035005806 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 585035005807 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 585035005808 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 585035005809 flagellar hook-length control protein; Provisional; Region: PRK10118 585035005810 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 585035005811 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 585035005812 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 585035005813 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 585035005814 flagellar motor switch protein; Validated; Region: fliN; PRK05698 585035005815 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 585035005816 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 585035005817 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 585035005818 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 585035005819 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 585035005820 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585035005821 DNA binding residues [nucleotide binding] 585035005822 dimerization interface [polypeptide binding]; other site 585035005823 hypothetical protein; Provisional; Region: PRK10708 585035005824 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 585035005825 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 585035005826 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585035005827 active site 585035005828 motif I; other site 585035005829 motif II; other site 585035005830 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 585035005831 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585035005832 metal binding site [ion binding]; metal-binding site 585035005833 active site 585035005834 I-site; other site 585035005835 hypothetical protein; Provisional; Region: PRK10062 585035005836 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 585035005837 EamA-like transporter family; Region: EamA; pfam00892 585035005838 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 585035005839 additional DNA contacts [nucleotide binding]; other site 585035005840 mismatch recognition site; other site 585035005841 active site 585035005842 zinc binding site [ion binding]; other site 585035005843 DNA intercalation site [nucleotide binding]; other site 585035005844 DNA cytosine methylase; Provisional; Region: PRK10458 585035005845 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 585035005846 cofactor binding site; other site 585035005847 DNA binding site [nucleotide binding] 585035005848 substrate interaction site [chemical binding]; other site 585035005849 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 585035005850 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 585035005851 Zn2+ binding site [ion binding]; other site 585035005852 Mg2+ binding site [ion binding]; other site 585035005853 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 585035005854 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585035005855 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 585035005856 eyelet of channel; other site 585035005857 trimer interface [polypeptide binding]; other site 585035005858 chaperone protein HchA; Provisional; Region: PRK04155 585035005859 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 585035005860 dimer interface [polypeptide binding]; other site 585035005861 metal binding site [ion binding]; metal-binding site 585035005862 potential oxyanion hole; other site 585035005863 potential catalytic triad [active] 585035005864 conserved cys residue [active] 585035005865 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 585035005866 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585035005867 dimer interface [polypeptide binding]; other site 585035005868 phosphorylation site [posttranslational modification] 585035005869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035005870 ATP binding site [chemical binding]; other site 585035005871 Mg2+ binding site [ion binding]; other site 585035005872 G-X-G motif; other site 585035005873 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 585035005874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035005875 active site 585035005876 phosphorylation site [posttranslational modification] 585035005877 intermolecular recognition site; other site 585035005878 dimerization interface [polypeptide binding]; other site 585035005879 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585035005880 DNA binding site [nucleotide binding] 585035005881 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 585035005882 active site 585035005883 homotetramer interface [polypeptide binding]; other site 585035005884 TMAO/DMSO reductase; Reviewed; Region: PRK05363 585035005885 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 585035005886 Moco binding site; other site 585035005887 metal coordination site [ion binding]; other site 585035005888 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 585035005889 zinc/cadmium-binding protein; Provisional; Region: PRK10306 585035005890 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 585035005891 Evidence 2b : Function of strongly homologous gene; PubMedId : 9988474; Product type h : extrachromosomal origin 585035005892 salicylate synthase Irp9; Reviewed; Region: PRK06772 585035005893 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 585035005894 muropeptide transporter; Validated; Region: ampG; cl17669 585035005895 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 585035005896 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585035005897 Walker A/P-loop; other site 585035005898 ATP binding site [chemical binding]; other site 585035005899 Q-loop/lid; other site 585035005900 ABC transporter signature motif; other site 585035005901 Walker B; other site 585035005902 D-loop; other site 585035005903 H-loop/switch region; other site 585035005904 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585035005905 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 585035005906 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585035005907 Walker A/P-loop; other site 585035005908 ATP binding site [chemical binding]; other site 585035005909 Q-loop/lid; other site 585035005910 ABC transporter signature motif; other site 585035005911 Walker B; other site 585035005912 D-loop; other site 585035005913 H-loop/switch region; other site 585035005914 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585035005915 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035005916 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 585035005917 Condensation domain; Region: Condensation; pfam00668 585035005918 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 585035005919 Nonribosomal peptide synthase; Region: NRPS; pfam08415 585035005920 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 585035005921 acyl-activating enzyme (AAE) consensus motif; other site 585035005922 AMP binding site [chemical binding]; other site 585035005923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035005924 S-adenosylmethionine binding site [chemical binding]; other site 585035005925 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 585035005926 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 585035005927 Condensation domain; Region: Condensation; pfam00668 585035005928 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 585035005929 Nonribosomal peptide synthase; Region: NRPS; pfam08415 585035005930 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 585035005931 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 585035005932 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 585035005933 active site 585035005934 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 585035005935 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 585035005936 Methyltransferase domain; Region: Methyltransf_12; pfam08242 585035005937 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 585035005938 KR domain; Region: KR; pfam08659 585035005939 NADP binding site [chemical binding]; other site 585035005940 active site 585035005941 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 585035005942 Condensation domain; Region: Condensation; pfam00668 585035005943 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 585035005944 Nonribosomal peptide synthase; Region: NRPS; pfam08415 585035005945 Methyltransferase domain; Region: Methyltransf_12; pfam08242 585035005946 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 585035005947 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 585035005948 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 585035005949 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 585035005950 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 585035005951 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 585035005952 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 585035005953 acyl-activating enzyme (AAE) consensus motif; other site 585035005954 active site 585035005955 AMP binding site [chemical binding]; other site 585035005956 substrate binding site [chemical binding]; other site 585035005957 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 585035005958 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585035005959 N-terminal plug; other site 585035005960 ligand-binding site [chemical binding]; other site 585035005961 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor 585035005962 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor 585035005963 Evidence 7 : Gene remnant; Product type f : factor 585035005964 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 585035005965 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 585035005966 shikimate transporter; Provisional; Region: PRK09952 585035005967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035005968 putative substrate translocation pore; other site 585035005969 AMP nucleosidase; Provisional; Region: PRK08292 585035005970 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 585035005971 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 585035005972 hypothetical protein; Provisional; Region: PRK12378 585035005973 MATE family multidrug exporter; Provisional; Region: PRK10189 585035005974 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 585035005975 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 585035005976 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035005977 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 585035005978 putative substrate binding site [chemical binding]; other site 585035005979 dimerization interface [polypeptide binding]; other site 585035005980 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 585035005981 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035005982 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 585035005983 putative dimerization interface [polypeptide binding]; other site 585035005984 L,D-transpeptidase; Provisional; Region: PRK10190 585035005985 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 585035005986 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 585035005987 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 585035005988 putative dimer interface [polypeptide binding]; other site 585035005989 active site pocket [active] 585035005990 putative cataytic base [active] 585035005991 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 585035005992 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 585035005993 homotrimer interface [polypeptide binding]; other site 585035005994 Walker A motif; other site 585035005995 GTP binding site [chemical binding]; other site 585035005996 Walker B motif; other site 585035005997 Evidence 7 : Gene remnant 585035005998 putative transposase OrfB; Reviewed; Region: PHA02517 585035005999 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585035006000 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 585035006001 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 585035006002 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 585035006003 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 585035006004 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585035006005 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 585035006006 substrate binding site [chemical binding]; other site 585035006007 dimer interface [polypeptide binding]; other site 585035006008 ATP binding site [chemical binding]; other site 585035006009 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 585035006010 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 585035006011 Protein of unknown function, DUF606; Region: DUF606; pfam04657 585035006012 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 585035006013 active site 585035006014 substrate binding pocket [chemical binding]; other site 585035006015 homodimer interaction site [polypeptide binding]; other site 585035006016 Evidence 7 : Gene remnant; PubMedId : 2570061; Product type e : enzyme 585035006017 Evidence 7 : Gene remnant; Product type pe : enzyme 585035006018 Evidence 2b : Function of strongly homologous gene; Product type pe : enzyme 585035006019 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 585035006020 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 585035006021 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 585035006022 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 585035006023 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585035006024 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 585035006025 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 585035006026 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 585035006027 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585035006028 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 585035006029 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585035006030 Transposase; Region: HTH_Tnp_1; pfam01527 585035006031 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 585035006032 similar to hypothetical protein; Evidence 6 : Doubtful CDS 585035006033 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 585035006034 homodimer interface [polypeptide binding]; other site 585035006035 putative GKAP docking site [polypeptide binding]; other site 585035006036 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 585035006037 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585035006038 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 585035006039 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 585035006040 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 585035006041 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 585035006042 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585035006043 similar to Insertion sequence IS21 ATP-binding protein; Evidence 7 : Gene remnant; Product type e : enzyme 585035006044 Predicted GTPase [General function prediction only]; Region: COG3596 585035006045 YfjP GTPase; Region: YfjP; cd11383 585035006046 G1 box; other site 585035006047 GTP/Mg2+ binding site [chemical binding]; other site 585035006048 Switch I region; other site 585035006049 G2 box; other site 585035006050 Switch II region; other site 585035006051 G3 box; other site 585035006052 G4 box; other site 585035006053 G5 box; other site 585035006054 hypothetical protein; Provisional; Region: PRK09866 585035006055 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 585035006056 G1 box; other site 585035006057 GTP/Mg2+ binding site [chemical binding]; other site 585035006058 G2 box; other site 585035006059 Switch I region; other site 585035006060 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 585035006061 G3 box; other site 585035006062 Switch II region; other site 585035006063 GTP/Mg2+ binding site [chemical binding]; other site 585035006064 G4 box; other site 585035006065 G5 box; other site 585035006066 YjcZ-like protein; Region: YjcZ; pfam13990 585035006067 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 585035006068 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 585035006069 nucleophile elbow; other site 585035006070 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 585035006071 Domain of unknown function (DUF932); Region: DUF932; pfam06067 585035006072 Antirestriction protein; Region: Antirestrict; pfam03230 585035006073 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 585035006074 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 585035006075 MPN+ (JAMM) motif; other site 585035006076 Zinc-binding site [ion binding]; other site 585035006077 Protein of unknown function (DUF987); Region: DUF987; pfam06174 585035006078 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 585035006079 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 585035006080 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 585035006081 Switch II region; other site 585035006082 G4 box; other site 585035006083 G5 box; other site 585035006084 hypothetical protein; Provisional; Region: PRK05423 585035006085 Predicted membrane protein [Function unknown]; Region: COG1289 585035006086 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 585035006087 DNA gyrase inhibitor; Provisional; Region: PRK10016 585035006088 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 585035006089 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 585035006090 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 585035006091 exonuclease I; Provisional; Region: sbcB; PRK11779 585035006092 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 585035006093 active site 585035006094 catalytic site [active] 585035006095 substrate binding site [chemical binding]; other site 585035006096 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 585035006097 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 585035006098 CPxP motif; other site 585035006099 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 585035006100 Sulphur transport; Region: Sulf_transp; pfam04143 585035006101 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 585035006102 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035006103 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 585035006104 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585035006105 dimerization interface [polypeptide binding]; other site 585035006106 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 585035006107 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 585035006108 putative NAD(P) binding site [chemical binding]; other site 585035006109 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 585035006110 antitoxin YefM; Provisional; Region: PRK11409 585035006111 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 585035006112 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 585035006113 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 585035006114 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 585035006115 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 585035006116 NAD binding site [chemical binding]; other site 585035006117 dimerization interface [polypeptide binding]; other site 585035006118 product binding site; other site 585035006119 substrate binding site [chemical binding]; other site 585035006120 zinc binding site [ion binding]; other site 585035006121 catalytic residues [active] 585035006122 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 585035006123 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585035006124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035006125 homodimer interface [polypeptide binding]; other site 585035006126 catalytic residue [active] 585035006127 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 585035006128 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585035006129 active site 585035006130 motif I; other site 585035006131 motif II; other site 585035006132 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 585035006133 putative active site pocket [active] 585035006134 4-fold oligomerization interface [polypeptide binding]; other site 585035006135 metal binding residues [ion binding]; metal-binding site 585035006136 3-fold/trimer interface [polypeptide binding]; other site 585035006137 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 585035006138 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 585035006139 putative active site [active] 585035006140 oxyanion strand; other site 585035006141 catalytic triad [active] 585035006142 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 585035006143 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 585035006144 catalytic residues [active] 585035006145 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 585035006146 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 585035006147 substrate binding site [chemical binding]; other site 585035006148 glutamase interaction surface [polypeptide binding]; other site 585035006149 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 585035006150 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 585035006151 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 585035006152 metal binding site [ion binding]; metal-binding site 585035006153 chain length determinant protein WzzB; Provisional; Region: PRK15471 585035006154 Chain length determinant protein; Region: Wzz; pfam02706 585035006155 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 585035006156 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 585035006157 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 585035006158 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 585035006159 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 585035006160 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 585035006161 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 585035006162 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 585035006163 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 585035006164 substrate binding site; other site 585035006165 tetramer interface; other site 585035006166 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 585035006167 trimer interface [polypeptide binding]; other site 585035006168 active site 585035006169 substrate binding site [chemical binding]; other site 585035006170 CoA binding site [chemical binding]; other site 585035006171 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 585035006172 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 585035006173 active site 585035006174 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 585035006175 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 585035006176 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 585035006177 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 585035006178 extended (e) SDRs; Region: SDR_e; cd08946 585035006179 NAD(P) binding site [chemical binding]; other site 585035006180 active site 585035006181 substrate binding site [chemical binding]; other site 585035006182 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 585035006183 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 585035006184 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 585035006185 NAD binding site [chemical binding]; other site 585035006186 substrate binding site [chemical binding]; other site 585035006187 homodimer interface [polypeptide binding]; other site 585035006188 active site 585035006189 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 585035006190 active site 585035006191 tetramer interface; other site 585035006192 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 585035006193 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 585035006194 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 585035006195 putative ADP-binding pocket [chemical binding]; other site 585035006196 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 585035006197 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 585035006198 colanic acid exporter; Provisional; Region: PRK10459 585035006199 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 585035006200 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 585035006201 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 585035006202 phosphomannomutase CpsG; Provisional; Region: PRK15414 585035006203 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 585035006204 active site 585035006205 substrate binding site [chemical binding]; other site 585035006206 metal binding site [ion binding]; metal-binding site 585035006207 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 585035006208 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 585035006209 Substrate binding site; other site 585035006210 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 585035006211 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 585035006212 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 585035006213 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 585035006214 active site 585035006215 GDP-Mannose binding site [chemical binding]; other site 585035006216 dimer interface [polypeptide binding]; other site 585035006217 modified nudix motif 585035006218 metal binding site [ion binding]; metal-binding site 585035006219 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 585035006220 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 585035006221 NADP binding site [chemical binding]; other site 585035006222 active site 585035006223 putative substrate binding site [chemical binding]; other site 585035006224 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 585035006225 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 585035006226 NADP-binding site; other site 585035006227 homotetramer interface [polypeptide binding]; other site 585035006228 substrate binding site [chemical binding]; other site 585035006229 homodimer interface [polypeptide binding]; other site 585035006230 active site 585035006231 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 585035006232 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 585035006233 putative trimer interface [polypeptide binding]; other site 585035006234 putative active site [active] 585035006235 putative substrate binding site [chemical binding]; other site 585035006236 putative CoA binding site [chemical binding]; other site 585035006237 putative glycosyl transferase; Provisional; Region: PRK10063 585035006238 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 585035006239 metal-binding site 585035006240 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 585035006241 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 585035006242 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 585035006243 putative acyl transferase; Provisional; Region: PRK10191 585035006244 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 585035006245 trimer interface [polypeptide binding]; other site 585035006246 active site 585035006247 substrate binding site [chemical binding]; other site 585035006248 CoA binding site [chemical binding]; other site 585035006249 putative glycosyl transferase; Provisional; Region: PRK10018 585035006250 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 585035006251 active site 585035006252 tyrosine kinase; Provisional; Region: PRK11519 585035006253 Chain length determinant protein; Region: Wzz; pfam02706 585035006254 Chain length determinant protein; Region: Wzz; cl15801 585035006255 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 585035006256 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 585035006257 Low molecular weight phosphatase family; Region: LMWPc; cd00115 585035006258 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 585035006259 active site 585035006260 polysaccharide export protein Wza; Provisional; Region: PRK15078 585035006261 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 585035006262 SLBB domain; Region: SLBB; pfam10531 585035006263 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 585035006264 FOG: CBS domain [General function prediction only]; Region: COG0517 585035006265 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 585035006266 Transporter associated domain; Region: CorC_HlyC; smart01091 585035006267 Phage-related protein [Function unknown]; Region: COG4679 585035006268 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 585035006269 putative assembly protein; Provisional; Region: PRK10833 585035006270 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 585035006271 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 585035006272 trimer interface [polypeptide binding]; other site 585035006273 active site 585035006274 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 585035006275 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 585035006276 ATP-binding site [chemical binding]; other site 585035006277 Sugar specificity; other site 585035006278 Pyrimidine base specificity; other site 585035006279 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 585035006280 putative diguanylate cyclase; Provisional; Region: PRK09776 585035006281 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585035006282 putative active site [active] 585035006283 heme pocket [chemical binding]; other site 585035006284 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585035006285 putative active site [active] 585035006286 heme pocket [chemical binding]; other site 585035006287 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585035006288 putative active site [active] 585035006289 heme pocket [chemical binding]; other site 585035006290 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585035006291 metal binding site [ion binding]; metal-binding site 585035006292 active site 585035006293 I-site; other site 585035006294 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 585035006295 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 585035006296 AlkA N-terminal domain; Region: AlkA_N; smart01009 585035006297 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 585035006298 minor groove reading motif; other site 585035006299 helix-hairpin-helix signature motif; other site 585035006300 substrate binding pocket [chemical binding]; other site 585035006301 active site 585035006302 putative chaperone; Provisional; Region: PRK11678 585035006303 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 585035006304 nucleotide binding site [chemical binding]; other site 585035006305 putative NEF/HSP70 interaction site [polypeptide binding]; other site 585035006306 SBD interface [polypeptide binding]; other site 585035006307 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 585035006308 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 585035006309 substrate binding site [chemical binding]; other site 585035006310 activation loop (A-loop); other site 585035006311 Y-family of DNA polymerases; Region: PolY; cl12025 585035006312 Protein phosphatase 2C; Region: PP2C_2; pfam13672 585035006313 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 585035006314 metal ion-dependent adhesion site (MIDAS); other site 585035006315 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 585035006316 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585035006317 HlyD family secretion protein; Region: HlyD_3; pfam13437 585035006318 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 585035006319 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 585035006320 Protein export membrane protein; Region: SecD_SecF; cl14618 585035006321 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 585035006322 putative transporter; Provisional; Region: PRK10504 585035006323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035006324 putative substrate translocation pore; other site 585035006325 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 585035006326 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585035006327 dimerization interface [polypeptide binding]; other site 585035006328 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585035006329 dimer interface [polypeptide binding]; other site 585035006330 phosphorylation site [posttranslational modification] 585035006331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035006332 ATP binding site [chemical binding]; other site 585035006333 Mg2+ binding site [ion binding]; other site 585035006334 G-X-G motif; other site 585035006335 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 585035006336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035006337 active site 585035006338 phosphorylation site [posttranslational modification] 585035006339 intermolecular recognition site; other site 585035006340 dimerization interface [polypeptide binding]; other site 585035006341 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585035006342 DNA binding site [nucleotide binding] 585035006343 Uncharacterized conserved protein [Function unknown]; Region: COG3422 585035006344 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 585035006345 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 585035006346 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 585035006347 PcfJ-like protein; Region: PcfJ; pfam14284 585035006348 putative protease; Provisional; Region: PRK15452 585035006349 Peptidase family U32; Region: Peptidase_U32; pfam01136 585035006350 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 585035006351 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 585035006352 tail protein; Provisional; Region: D; PHA02561 585035006353 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 585035006354 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 585035006355 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 585035006356 major tail tube protein; Provisional; Region: FII; PHA02600 585035006357 major tail sheath protein; Provisional; Region: FI; PHA02560 585035006358 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 585035006359 active site 585035006360 DNA binding site [nucleotide binding] 585035006361 Int/Topo IB signature motif; other site 585035006362 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 585035006363 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 585035006364 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 585035006365 phage tail protein, P2 protein I family; Region: tail_P2_I; TIGR01634 585035006366 baseplate assembly protein; Provisional; Region: J; PHA02568 585035006367 baseplate wedge subunit; Provisional; Region: W; PHA02516 585035006368 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 585035006369 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 585035006370 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 585035006371 synthetase active site [active] 585035006372 NTP binding site [chemical binding]; other site 585035006373 metal binding site [ion binding]; metal-binding site 585035006374 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 585035006375 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 585035006376 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 585035006377 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 585035006378 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585035006379 catalytic residue [active] 585035006380 Phage holin family 2; Region: Phage_holin_2; pfam04550 585035006381 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 585035006382 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 585035006383 terminase endonuclease subunit; Provisional; Region: M; PHA02537 585035006384 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 585035006385 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin 585035006386 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585035006387 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 585035006388 DNA binding residues [nucleotide binding] 585035006389 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 585035006390 Integrase core domain; Region: rve; pfam00665 585035006391 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 585035006392 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 585035006393 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035006394 Walker A motif; other site 585035006395 ATP binding site [chemical binding]; other site 585035006396 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin 585035006397 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929 585035006398 terminase ATPase subunit; Provisional; Region: P; PHA02535 585035006399 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 585035006400 portal vertex protein; Provisional; Region: Q; PHA02536 585035006401 Phage portal protein; Region: Phage_portal; pfam04860 585035006402 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 585035006403 DksA-like zinc finger domain containing protein; Region: PHA00080 585035006404 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 585035006405 Regulatory phage protein cox; Region: Phage_Cox; pfam10743 585035006406 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 585035006407 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585035006408 non-specific DNA binding site [nucleotide binding]; other site 585035006409 salt bridge; other site 585035006410 sequence-specific DNA binding site [nucleotide binding]; other site 585035006411 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 585035006412 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 585035006413 lipid kinase; Reviewed; Region: PRK13054 585035006414 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 585035006415 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 585035006416 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 585035006417 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585035006418 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 585035006419 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 585035006420 putative NAD(P) binding site [chemical binding]; other site 585035006421 catalytic Zn binding site [ion binding]; other site 585035006422 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 585035006423 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 585035006424 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 585035006425 active site 585035006426 P-loop; other site 585035006427 phosphorylation site [posttranslational modification] 585035006428 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585035006429 active site 585035006430 phosphorylation site [posttranslational modification] 585035006431 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 585035006432 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 585035006433 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 585035006434 intersubunit interface [polypeptide binding]; other site 585035006435 active site 585035006436 zinc binding site [ion binding]; other site 585035006437 Na+ binding site [ion binding]; other site 585035006438 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 585035006439 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 585035006440 putative active site; other site 585035006441 catalytic residue [active] 585035006442 nucleoside transporter; Region: 2A0110; TIGR00889 585035006443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035006444 putative substrate translocation pore; other site 585035006445 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 585035006446 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585035006447 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 585035006448 substrate binding site [chemical binding]; other site 585035006449 ATP binding site [chemical binding]; other site 585035006450 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 585035006451 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585035006452 DNA-binding site [nucleotide binding]; DNA binding site 585035006453 UTRA domain; Region: UTRA; pfam07702 585035006454 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 585035006455 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 585035006456 active site 585035006457 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 585035006458 dimer interface [polypeptide binding]; other site 585035006459 substrate binding site [chemical binding]; other site 585035006460 ATP binding site [chemical binding]; other site 585035006461 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 585035006462 substrate binding site [chemical binding]; other site 585035006463 multimerization interface [polypeptide binding]; other site 585035006464 ATP binding site [chemical binding]; other site 585035006465 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 585035006466 putative metal binding site [ion binding]; other site 585035006467 putative homodimer interface [polypeptide binding]; other site 585035006468 putative homotetramer interface [polypeptide binding]; other site 585035006469 putative homodimer-homodimer interface [polypeptide binding]; other site 585035006470 putative allosteric switch controlling residues; other site 585035006471 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 585035006472 Predicted integral membrane protein [Function unknown]; Region: COG5455 585035006473 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 585035006474 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 585035006475 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 585035006476 PapC N-terminal domain; Region: PapC_N; pfam13954 585035006477 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585035006478 PapC C-terminal domain; Region: PapC_C; pfam13953 585035006479 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 585035006480 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585035006481 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585035006482 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585035006483 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 585035006484 antiporter inner membrane protein; Provisional; Region: PRK11670 585035006485 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 585035006486 Walker A motif; other site 585035006487 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 585035006488 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 585035006489 active site 585035006490 HIGH motif; other site 585035006491 KMSKS motif; other site 585035006492 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 585035006493 tRNA binding surface [nucleotide binding]; other site 585035006494 anticodon binding site; other site 585035006495 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 585035006496 dimer interface [polypeptide binding]; other site 585035006497 putative tRNA-binding site [nucleotide binding]; other site 585035006498 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 585035006499 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 585035006500 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 585035006501 MoxR-like ATPases [General function prediction only]; Region: COG0714 585035006502 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035006503 Walker A motif; other site 585035006504 ATP binding site [chemical binding]; other site 585035006505 Walker B motif; other site 585035006506 arginine finger; other site 585035006507 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 585035006508 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 585035006509 metal ion-dependent adhesion site (MIDAS); other site 585035006510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 585035006511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 585035006512 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 585035006513 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 585035006514 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 585035006515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035006516 active site 585035006517 phosphorylation site [posttranslational modification] 585035006518 intermolecular recognition site; other site 585035006519 dimerization interface [polypeptide binding]; other site 585035006520 LytTr DNA-binding domain; Region: LytTR; pfam04397 585035006521 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 585035006522 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 585035006523 GAF domain; Region: GAF; pfam01590 585035006524 Histidine kinase; Region: His_kinase; pfam06580 585035006525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035006526 ATP binding site [chemical binding]; other site 585035006527 Mg2+ binding site [ion binding]; other site 585035006528 G-X-G motif; other site 585035006529 transcriptional regulator MirA; Provisional; Region: PRK15043 585035006530 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 585035006531 DNA binding residues [nucleotide binding] 585035006532 hypothetical protein; Provisional; Region: PRK13681 585035006533 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 585035006534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035006535 dimer interface [polypeptide binding]; other site 585035006536 conserved gate region; other site 585035006537 putative PBP binding loops; other site 585035006538 ABC-ATPase subunit interface; other site 585035006539 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 585035006540 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 585035006541 Walker A/P-loop; other site 585035006542 ATP binding site [chemical binding]; other site 585035006543 Q-loop/lid; other site 585035006544 ABC transporter signature motif; other site 585035006545 Walker B; other site 585035006546 D-loop; other site 585035006547 H-loop/switch region; other site 585035006548 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 585035006549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035006550 dimer interface [polypeptide binding]; other site 585035006551 conserved gate region; other site 585035006552 ABC-ATPase subunit interface; other site 585035006553 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 585035006554 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 585035006555 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 585035006556 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 585035006557 D-lactate dehydrogenase; Provisional; Region: PRK11183 585035006558 FAD binding domain; Region: FAD_binding_4; pfam01565 585035006559 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 585035006560 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 585035006561 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 585035006562 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 585035006563 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 585035006564 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 585035006565 oxidoreductase; Provisional; Region: PRK12743 585035006566 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 585035006567 NAD(P) binding site [chemical binding]; other site 585035006568 active site 585035006569 Outer membrane efflux protein; Region: OEP; pfam02321 585035006570 Outer membrane efflux protein; Region: OEP; pfam02321 585035006571 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 585035006572 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 585035006573 FMN binding site [chemical binding]; other site 585035006574 active site 585035006575 catalytic residues [active] 585035006576 substrate binding site [chemical binding]; other site 585035006577 hypothetical protein; Provisional; Region: PRK01821 585035006578 hypothetical protein; Provisional; Region: PRK10711 585035006579 cytidine deaminase; Provisional; Region: PRK09027 585035006580 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 585035006581 active site 585035006582 catalytic motif [active] 585035006583 Zn binding site [ion binding]; other site 585035006584 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 585035006585 active site 585035006586 catalytic motif [active] 585035006587 Zn binding site [ion binding]; other site 585035006588 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 585035006589 putative active site [active] 585035006590 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 585035006591 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 585035006592 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 585035006593 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585035006594 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 585035006595 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 585035006596 homodimer interface [polypeptide binding]; other site 585035006597 active site 585035006598 FMN binding site [chemical binding]; other site 585035006599 substrate binding site [chemical binding]; other site 585035006600 4Fe-4S binding domain; Region: Fer4; pfam00037 585035006601 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585035006602 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585035006603 TM-ABC transporter signature motif; other site 585035006604 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585035006605 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 585035006606 Walker A/P-loop; other site 585035006607 ATP binding site [chemical binding]; other site 585035006608 Q-loop/lid; other site 585035006609 ABC transporter signature motif; other site 585035006610 Walker B; other site 585035006611 D-loop; other site 585035006612 H-loop/switch region; other site 585035006613 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585035006614 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 585035006615 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 585035006616 ligand binding site [chemical binding]; other site 585035006617 calcium binding site [ion binding]; other site 585035006618 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 585035006619 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585035006620 DNA binding site [nucleotide binding] 585035006621 domain linker motif; other site 585035006622 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 585035006623 dimerization interface (closed form) [polypeptide binding]; other site 585035006624 ligand binding site [chemical binding]; other site 585035006625 Predicted membrane protein [Function unknown]; Region: COG2311 585035006626 hypothetical protein; Provisional; Region: PRK10835 585035006627 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 585035006628 homodecamer interface [polypeptide binding]; other site 585035006629 GTP cyclohydrolase I; Provisional; Region: PLN03044 585035006630 active site 585035006631 putative catalytic site residues [active] 585035006632 zinc binding site [ion binding]; other site 585035006633 GTP-CH-I/GFRP interaction surface; other site 585035006634 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 585035006635 S-formylglutathione hydrolase; Region: PLN02442 585035006636 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 585035006637 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585035006638 N-terminal plug; other site 585035006639 ligand-binding site [chemical binding]; other site 585035006640 lysine transporter; Provisional; Region: PRK10836 585035006641 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 585035006642 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035006643 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 585035006644 putative dimerization interface [polypeptide binding]; other site 585035006645 conserved hypothetical integral membrane protein; Region: TIGR00698 585035006646 endonuclease IV; Provisional; Region: PRK01060 585035006647 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 585035006648 AP (apurinic/apyrimidinic) site pocket; other site 585035006649 DNA interaction; other site 585035006650 Metal-binding active site; metal-binding site 585035006651 putative kinase; Provisional; Region: PRK09954 585035006652 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585035006653 putative DNA binding site [nucleotide binding]; other site 585035006654 putative Zn2+ binding site [ion binding]; other site 585035006655 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 585035006656 substrate binding site [chemical binding]; other site 585035006657 ATP binding site [chemical binding]; other site 585035006658 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 585035006659 active site 585035006660 tetramer interface [polypeptide binding]; other site 585035006661 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 585035006662 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 585035006663 ligand binding site [chemical binding]; other site 585035006664 flexible hinge region; other site 585035006665 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 585035006666 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 585035006667 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 585035006668 Nucleoside recognition; Region: Gate; pfam07670 585035006669 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 585035006670 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 585035006671 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 585035006672 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585035006673 substrate binding site [chemical binding]; other site 585035006674 ATP binding site [chemical binding]; other site 585035006675 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 585035006676 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 585035006677 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 585035006678 active site 585035006679 P-loop; other site 585035006680 phosphorylation site [posttranslational modification] 585035006681 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 585035006682 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 585035006683 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 585035006684 putative substrate binding site [chemical binding]; other site 585035006685 putative ATP binding site [chemical binding]; other site 585035006686 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 585035006687 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585035006688 active site 585035006689 phosphorylation site [posttranslational modification] 585035006690 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585035006691 dimerization domain swap beta strand [polypeptide binding]; other site 585035006692 regulatory protein interface [polypeptide binding]; other site 585035006693 active site 585035006694 regulatory phosphorylation site [posttranslational modification]; other site 585035006695 sugar efflux transporter B; Provisional; Region: PRK15011 585035006696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035006697 putative substrate translocation pore; other site 585035006698 Flagellin N-methylase; Region: FliB; pfam03692 585035006699 elongation factor P; Provisional; Region: PRK04542 585035006700 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 585035006701 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 585035006702 RNA binding site [nucleotide binding]; other site 585035006703 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 585035006704 RNA binding site [nucleotide binding]; other site 585035006705 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 585035006706 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 585035006707 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 585035006708 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 585035006709 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 585035006710 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 585035006711 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 585035006712 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 585035006713 active site 585035006714 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 585035006715 NlpC/P60 family; Region: NLPC_P60; pfam00877 585035006716 phage resistance protein; Provisional; Region: PRK10551 585035006717 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 585035006718 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585035006719 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 585035006720 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 585035006721 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 585035006722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035006723 dimer interface [polypeptide binding]; other site 585035006724 conserved gate region; other site 585035006725 putative PBP binding loops; other site 585035006726 ABC-ATPase subunit interface; other site 585035006727 microcin C ABC transporter permease; Provisional; Region: PRK15021 585035006728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035006729 dimer interface [polypeptide binding]; other site 585035006730 conserved gate region; other site 585035006731 ABC-ATPase subunit interface; other site 585035006732 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 585035006733 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585035006734 Walker A/P-loop; other site 585035006735 ATP binding site [chemical binding]; other site 585035006736 Q-loop/lid; other site 585035006737 ABC transporter signature motif; other site 585035006738 Walker B; other site 585035006739 D-loop; other site 585035006740 H-loop/switch region; other site 585035006741 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 585035006742 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585035006743 Walker A/P-loop; other site 585035006744 ATP binding site [chemical binding]; other site 585035006745 Q-loop/lid; other site 585035006746 ABC transporter signature motif; other site 585035006747 Walker B; other site 585035006748 D-loop; other site 585035006749 H-loop/switch region; other site 585035006750 hypothetical protein; Provisional; Region: PRK11835 585035006751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035006752 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 585035006753 putative substrate translocation pore; other site 585035006754 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 585035006755 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585035006756 RNA binding surface [nucleotide binding]; other site 585035006757 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 585035006758 active site 585035006759 uracil binding [chemical binding]; other site 585035006760 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 585035006761 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585035006762 ATP binding site [chemical binding]; other site 585035006763 putative Mg++ binding site [ion binding]; other site 585035006764 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585035006765 nucleotide binding region [chemical binding]; other site 585035006766 ATP-binding site [chemical binding]; other site 585035006767 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 585035006768 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 585035006769 5S rRNA interface [nucleotide binding]; other site 585035006770 CTC domain interface [polypeptide binding]; other site 585035006771 L16 interface [polypeptide binding]; other site 585035006772 Nucleoid-associated protein [General function prediction only]; Region: COG3081 585035006773 nucleoid-associated protein NdpA; Validated; Region: PRK00378 585035006774 hypothetical protein; Provisional; Region: PRK13689 585035006775 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 585035006776 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 585035006777 Sulfatase; Region: Sulfatase; pfam00884 585035006778 Evidence 4 : Homologs of previously reported genes of unknown function 585035006779 transcriptional regulator NarP; Provisional; Region: PRK10403 585035006780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035006781 active site 585035006782 phosphorylation site [posttranslational modification] 585035006783 intermolecular recognition site; other site 585035006784 dimerization interface [polypeptide binding]; other site 585035006785 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585035006786 DNA binding residues [nucleotide binding] 585035006787 dimerization interface [polypeptide binding]; other site 585035006788 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 585035006789 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 585035006790 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 585035006791 binding surface 585035006792 TPR motif; other site 585035006793 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 585035006794 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 585035006795 catalytic residues [active] 585035006796 central insert; other site 585035006797 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 585035006798 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 585035006799 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 585035006800 heme exporter protein CcmC; Region: ccmC; TIGR01191 585035006801 heme exporter protein CcmB; Region: ccmB; TIGR01190 585035006802 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 585035006803 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 585035006804 Walker A/P-loop; other site 585035006805 ATP binding site [chemical binding]; other site 585035006806 Q-loop/lid; other site 585035006807 ABC transporter signature motif; other site 585035006808 Walker B; other site 585035006809 D-loop; other site 585035006810 H-loop/switch region; other site 585035006811 cytochrome c-type protein NapC; Provisional; Region: PRK10617 585035006812 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 585035006813 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 585035006814 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 585035006815 4Fe-4S binding domain; Region: Fer4_5; pfam12801 585035006816 4Fe-4S binding domain; Region: Fer4_6; pfam12837 585035006817 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 585035006818 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 585035006819 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 585035006820 [4Fe-4S] binding site [ion binding]; other site 585035006821 molybdopterin cofactor binding site; other site 585035006822 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 585035006823 molybdopterin cofactor binding site; other site 585035006824 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 585035006825 ferredoxin-type protein; Provisional; Region: PRK10194 585035006826 tRNA synthetases class I (R); Region: tRNA-synt_1d; pfam00750 585035006827 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 585035006828 secondary substrate binding site; other site 585035006829 primary substrate binding site; other site 585035006830 inhibition loop; other site 585035006831 dimerization interface [polypeptide binding]; other site 585035006832 malate:quinone oxidoreductase; Validated; Region: PRK05257 585035006833 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 585035006834 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 585035006835 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 585035006836 Walker A/P-loop; other site 585035006837 ATP binding site [chemical binding]; other site 585035006838 Q-loop/lid; other site 585035006839 ABC transporter signature motif; other site 585035006840 Walker B; other site 585035006841 D-loop; other site 585035006842 H-loop/switch region; other site 585035006843 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 585035006844 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 585035006845 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 585035006846 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035006847 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 585035006848 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 585035006849 DNA binding site [nucleotide binding] 585035006850 active site 585035006851 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 585035006852 ApbE family; Region: ApbE; pfam02424 585035006853 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 585035006854 outer membrane porin protein C; Provisional; Region: PRK10554 585035006855 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 585035006856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035006857 ATP binding site [chemical binding]; other site 585035006858 G-X-G motif; other site 585035006859 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 585035006860 putative binding surface; other site 585035006861 active site 585035006862 transcriptional regulator RcsB; Provisional; Region: PRK10840 585035006863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035006864 active site 585035006865 phosphorylation site [posttranslational modification] 585035006866 intermolecular recognition site; other site 585035006867 dimerization interface [polypeptide binding]; other site 585035006868 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585035006869 DNA binding residues [nucleotide binding] 585035006870 dimerization interface [polypeptide binding]; other site 585035006871 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 585035006872 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585035006873 dimer interface [polypeptide binding]; other site 585035006874 phosphorylation site [posttranslational modification] 585035006875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035006876 ATP binding site [chemical binding]; other site 585035006877 Mg2+ binding site [ion binding]; other site 585035006878 G-X-G motif; other site 585035006879 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 585035006880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035006881 active site 585035006882 phosphorylation site [posttranslational modification] 585035006883 intermolecular recognition site; other site 585035006884 dimerization interface [polypeptide binding]; other site 585035006885 sensory histidine kinase AtoS; Provisional; Region: PRK11360 585035006886 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585035006887 putative active site [active] 585035006888 heme pocket [chemical binding]; other site 585035006889 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585035006890 dimer interface [polypeptide binding]; other site 585035006891 phosphorylation site [posttranslational modification] 585035006892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035006893 ATP binding site [chemical binding]; other site 585035006894 Mg2+ binding site [ion binding]; other site 585035006895 G-X-G motif; other site 585035006896 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 585035006897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035006898 active site 585035006899 phosphorylation site [posttranslational modification] 585035006900 intermolecular recognition site; other site 585035006901 dimerization interface [polypeptide binding]; other site 585035006902 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035006903 Walker A motif; other site 585035006904 ATP binding site [chemical binding]; other site 585035006905 Walker B motif; other site 585035006906 arginine finger; other site 585035006907 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585035006908 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920 585035006909 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 585035006910 Short chain fatty acid transporter; Region: SCFA_trans; pfam02667 585035006911 putative acyltransferase; Provisional; Region: PRK05790 585035006912 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 585035006913 dimer interface [polypeptide binding]; other site 585035006914 active site 585035006915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 585035006916 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 585035006917 Predicted secreted protein [Function unknown]; Region: COG5445 585035006918 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 585035006919 Predicted secreted protein [Function unknown]; Region: COG5445 585035006920 Stage II sporulation protein; Region: SpoIID; pfam08486 585035006921 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 585035006922 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 585035006923 MG2 domain; Region: A2M_N; pfam01835 585035006924 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 585035006925 Alpha-2-macroglobulin family; Region: A2M; pfam00207 585035006926 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 585035006927 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 585035006928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 585035006929 DNA gyrase subunit A; Validated; Region: PRK05560 585035006930 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 585035006931 CAP-like domain; other site 585035006932 active site 585035006933 primary dimer interface [polypeptide binding]; other site 585035006934 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585035006935 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585035006936 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585035006937 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585035006938 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585035006939 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585035006940 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 585035006941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035006942 S-adenosylmethionine binding site [chemical binding]; other site 585035006943 adhesin; Provisional; Region: PRK09752 585035006944 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 585035006945 Autotransporter beta-domain; Region: Autotransporter; pfam03797 585035006946 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 585035006947 ATP cone domain; Region: ATP-cone; pfam03477 585035006948 Class I ribonucleotide reductase; Region: RNR_I; cd01679 585035006949 active site 585035006950 dimer interface [polypeptide binding]; other site 585035006951 catalytic residues [active] 585035006952 effector binding site; other site 585035006953 R2 peptide binding site; other site 585035006954 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 585035006955 dimer interface [polypeptide binding]; other site 585035006956 putative radical transfer pathway; other site 585035006957 diiron center [ion binding]; other site 585035006958 tyrosyl radical; other site 585035006959 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 585035006960 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585035006961 catalytic loop [active] 585035006962 iron binding site [ion binding]; other site 585035006963 hypothetical protein; Provisional; Region: PRK09902 585035006964 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 585035006965 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 585035006966 active site 585035006967 catalytic site [active] 585035006968 metal binding site [ion binding]; metal-binding site 585035006969 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 585035006970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035006971 putative substrate translocation pore; other site 585035006972 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 585035006973 hydroxyglutarate oxidase; Provisional; Region: PRK11728 585035006974 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 585035006975 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 585035006976 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 585035006977 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 585035006978 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585035006979 Cysteine-rich domain; Region: CCG; pfam02754 585035006980 Cysteine-rich domain; Region: CCG; pfam02754 585035006981 hypothetical protein; Provisional; Region: PRK09956 585035006982 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 585035006983 hypothetical protein; Provisional; Region: PRK09956 585035006984 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 585035006985 Evidence 7 : Gene remnant; Product type pt : transporter 585035006986 Evidence 7 : Gene remnant; Product type pt : transporter 585035006987 L-rhamnonate dehydratase; Provisional; Region: PRK15440 585035006988 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 585035006989 putative active site pocket [active] 585035006990 putative metal binding site [ion binding]; other site 585035006991 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 585035006992 Transcriptional regulator [Transcription]; Region: IclR; COG1414 585035006993 Bacterial transcriptional regulator; Region: IclR; pfam01614 585035006994 hypothetical protein; Provisional; Region: PRK03673 585035006995 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 585035006996 putative MPT binding site; other site 585035006997 Competence-damaged protein; Region: CinA; cl00666 585035006998 YfaZ precursor; Region: YfaZ; pfam07437 585035006999 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 585035007000 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 585035007001 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 585035007002 catalytic core [active] 585035007003 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 585035007004 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 585035007005 inhibitor-cofactor binding pocket; inhibition site 585035007006 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035007007 catalytic residue [active] 585035007008 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 585035007009 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 585035007010 Ligand binding site; other site 585035007011 Putative Catalytic site; other site 585035007012 DXD motif; other site 585035007013 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 585035007014 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 585035007015 substrate binding site [chemical binding]; other site 585035007016 cosubstrate binding site; other site 585035007017 catalytic site [active] 585035007018 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 585035007019 active site 585035007020 hexamer interface [polypeptide binding]; other site 585035007021 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 585035007022 NAD binding site [chemical binding]; other site 585035007023 substrate binding site [chemical binding]; other site 585035007024 active site 585035007025 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 585035007026 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 585035007027 putative active site [active] 585035007028 putative catalytic site [active] 585035007029 putative Zn binding site [ion binding]; other site 585035007030 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 585035007031 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 585035007032 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 585035007033 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 585035007034 signal transduction protein PmrD; Provisional; Region: PRK15450 585035007035 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 585035007036 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 585035007037 acyl-activating enzyme (AAE) consensus motif; other site 585035007038 putative AMP binding site [chemical binding]; other site 585035007039 putative active site [active] 585035007040 putative CoA binding site [chemical binding]; other site 585035007041 O-succinylbenzoate synthase; Provisional; Region: PRK05105 585035007042 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 585035007043 active site 585035007044 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585035007045 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 585035007046 substrate binding site [chemical binding]; other site 585035007047 oxyanion hole (OAH) forming residues; other site 585035007048 trimer interface [polypeptide binding]; other site 585035007049 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 585035007050 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 585035007051 catalytic site [active] 585035007052 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 585035007053 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 585035007054 dimer interface [polypeptide binding]; other site 585035007055 tetramer interface [polypeptide binding]; other site 585035007056 PYR/PP interface [polypeptide binding]; other site 585035007057 TPP binding site [chemical binding]; other site 585035007058 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 585035007059 TPP-binding site; other site 585035007060 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 585035007061 isochorismate synthases; Region: isochor_syn; TIGR00543 585035007062 hypothetical protein; Provisional; Region: PRK10404 585035007063 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585035007064 Coenzyme A binding pocket [chemical binding]; other site 585035007065 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 585035007066 von Willebrand factor; Region: vWF_A; pfam12450 585035007067 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 585035007068 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 585035007069 metal ion-dependent adhesion site (MIDAS); other site 585035007070 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 585035007071 M28 Zn-Peptidases; Region: M28_like_1; cd05640 585035007072 Peptidase family M28; Region: Peptidase_M28; pfam04389 585035007073 metal binding site [ion binding]; metal-binding site 585035007074 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 585035007075 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 585035007076 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 585035007077 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 585035007078 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 585035007079 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 585035007080 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 585035007081 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 585035007082 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 585035007083 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 585035007084 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 585035007085 4Fe-4S binding domain; Region: Fer4; pfam00037 585035007086 4Fe-4S binding domain; Region: Fer4; pfam00037 585035007087 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 585035007088 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 585035007089 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585035007090 catalytic loop [active] 585035007091 iron binding site [ion binding]; other site 585035007092 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 585035007093 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 585035007094 [4Fe-4S] binding site [ion binding]; other site 585035007095 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 585035007096 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 585035007097 SLBB domain; Region: SLBB; pfam10531 585035007098 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 585035007099 NADH dehydrogenase subunit E; Validated; Region: PRK07539 585035007100 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 585035007101 putative dimer interface [polypeptide binding]; other site 585035007102 [2Fe-2S] cluster binding site [ion binding]; other site 585035007103 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 585035007104 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 585035007105 NADH dehydrogenase subunit D; Validated; Region: PRK06075 585035007106 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 585035007107 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 585035007108 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 585035007109 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035007110 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 585035007111 putative dimerization interface [polypeptide binding]; other site 585035007112 aminotransferase AlaT; Validated; Region: PRK09265 585035007113 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585035007114 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035007115 homodimer interface [polypeptide binding]; other site 585035007116 catalytic residue [active] 585035007117 5'-nucleotidase; Provisional; Region: PRK03826 585035007118 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 585035007119 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 585035007120 TrkA-C domain; Region: TrkA_C; pfam02080 585035007121 TrkA-C domain; Region: TrkA_C; pfam02080 585035007122 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 585035007123 putative phosphatase; Provisional; Region: PRK11587 585035007124 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585035007125 motif II; other site 585035007126 hypothetical protein; Validated; Region: PRK05445 585035007127 hypothetical protein; Provisional; Region: PRK01816 585035007128 propionate/acetate kinase; Provisional; Region: PRK12379 585035007129 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 585035007130 phosphate acetyltransferase; Reviewed; Region: PRK05632 585035007131 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 585035007132 DRTGG domain; Region: DRTGG; pfam07085 585035007133 phosphate acetyltransferase; Region: pta; TIGR00651 585035007134 hypothetical protein; Provisional; Region: PRK11588 585035007135 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 585035007136 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 585035007137 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 585035007138 nudix motif; other site 585035007139 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 585035007140 active site 585035007141 metal binding site [ion binding]; metal-binding site 585035007142 homotetramer interface [polypeptide binding]; other site 585035007143 glutathione S-transferase; Provisional; Region: PRK15113 585035007144 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 585035007145 C-terminal domain interface [polypeptide binding]; other site 585035007146 GSH binding site (G-site) [chemical binding]; other site 585035007147 dimer interface [polypeptide binding]; other site 585035007148 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 585035007149 N-terminal domain interface [polypeptide binding]; other site 585035007150 putative dimer interface [polypeptide binding]; other site 585035007151 putative substrate binding pocket (H-site) [chemical binding]; other site 585035007152 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 585035007153 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 585035007154 C-terminal domain interface [polypeptide binding]; other site 585035007155 GSH binding site (G-site) [chemical binding]; other site 585035007156 dimer interface [polypeptide binding]; other site 585035007157 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 585035007158 N-terminal domain interface [polypeptide binding]; other site 585035007159 putative dimer interface [polypeptide binding]; other site 585035007160 active site 585035007161 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 585035007162 homooctamer interface [polypeptide binding]; other site 585035007163 active site 585035007164 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 585035007165 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 585035007166 putative NAD(P) binding site [chemical binding]; other site 585035007167 putative active site [active] 585035007168 putative transposase; Provisional; Region: PRK09857 585035007169 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 585035007170 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 585035007171 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 585035007172 Walker A/P-loop; other site 585035007173 ATP binding site [chemical binding]; other site 585035007174 Q-loop/lid; other site 585035007175 ABC transporter signature motif; other site 585035007176 Walker B; other site 585035007177 D-loop; other site 585035007178 H-loop/switch region; other site 585035007179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035007180 dimer interface [polypeptide binding]; other site 585035007181 conserved gate region; other site 585035007182 putative PBP binding loops; other site 585035007183 ABC-ATPase subunit interface; other site 585035007184 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585035007185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035007186 dimer interface [polypeptide binding]; other site 585035007187 conserved gate region; other site 585035007188 putative PBP binding loops; other site 585035007189 ABC-ATPase subunit interface; other site 585035007190 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 585035007191 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585035007192 substrate binding pocket [chemical binding]; other site 585035007193 membrane-bound complex binding site; other site 585035007194 hinge residues; other site 585035007195 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 585035007196 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585035007197 substrate binding pocket [chemical binding]; other site 585035007198 membrane-bound complex binding site; other site 585035007199 hinge residues; other site 585035007200 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 585035007201 Flavoprotein; Region: Flavoprotein; pfam02441 585035007202 amidophosphoribosyltransferase; Provisional; Region: PRK09246 585035007203 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 585035007204 active site 585035007205 tetramer interface [polypeptide binding]; other site 585035007206 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585035007207 active site 585035007208 colicin V production protein; Provisional; Region: PRK10845 585035007209 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 585035007210 cell division protein DedD; Provisional; Region: PRK11633 585035007211 Sporulation related domain; Region: SPOR; pfam05036 585035007212 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 585035007213 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 585035007214 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 585035007215 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 585035007216 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 585035007217 hypothetical protein; Provisional; Region: PRK10847 585035007218 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 585035007219 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 585035007220 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 585035007221 dimerization interface 3.5A [polypeptide binding]; other site 585035007222 active site 585035007223 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 585035007224 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 585035007225 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 585035007226 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 585035007227 ligand binding site [chemical binding]; other site 585035007228 NAD binding site [chemical binding]; other site 585035007229 catalytic site [active] 585035007230 homodimer interface [polypeptide binding]; other site 585035007231 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 585035007232 putative transporter; Provisional; Region: PRK12382 585035007233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035007234 putative substrate translocation pore; other site 585035007235 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 585035007236 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 585035007237 dimer interface [polypeptide binding]; other site 585035007238 active site 585035007239 Uncharacterized conserved protein [Function unknown]; Region: COG4121 585035007240 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 585035007241 YfcL protein; Region: YfcL; pfam08891 585035007242 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 585035007243 hypothetical protein; Provisional; Region: PRK10621 585035007244 Predicted permeases [General function prediction only]; Region: COG0730 585035007245 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 585035007246 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 585035007247 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 585035007248 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 585035007249 Tetramer interface [polypeptide binding]; other site 585035007250 active site 585035007251 FMN-binding site [chemical binding]; other site 585035007252 HemK family putative methylases; Region: hemK_fam; TIGR00536 585035007253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035007254 S-adenosylmethionine binding site [chemical binding]; other site 585035007255 hypothetical protein; Provisional; Region: PRK04946 585035007256 Smr domain; Region: Smr; pfam01713 585035007257 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 585035007258 Fimbrial protein; Region: Fimbrial; cl01416 585035007259 Fimbrial protein; Region: Fimbrial; cl01416 585035007260 Fimbrial protein; Region: Fimbrial; cl01416 585035007261 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585035007262 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585035007263 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 585035007264 PapC N-terminal domain; Region: PapC_N; pfam13954 585035007265 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585035007266 PapC C-terminal domain; Region: PapC_C; pfam13953 585035007267 Fimbrial protein; Region: Fimbrial; cl01416 585035007268 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 585035007269 catalytic core [active] 585035007270 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 585035007271 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585035007272 substrate binding site [chemical binding]; other site 585035007273 oxyanion hole (OAH) forming residues; other site 585035007274 trimer interface [polypeptide binding]; other site 585035007275 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 585035007276 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 585035007277 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 585035007278 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 585035007279 dimer interface [polypeptide binding]; other site 585035007280 active site 585035007281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 585035007282 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 585035007283 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 585035007284 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 585035007285 integrase; Provisional; Region: PRK09692 585035007286 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585035007287 active site 585035007288 Int/Topo IB signature motif; other site 585035007289 Evidence 2b : Function of strongly homologous gene; PubMedId : 15809431; Product type e : enzyme 585035007290 Head binding; Region: Head_binding; pfam09008 585035007291 N terminal extension of bacteriophage endosialidase; Region: End_N_terminal; pfam12218 585035007292 Beta barrel domain of bacteriophage endosialidase; Region: End_beta_barrel; pfam12195 585035007293 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 585035007294 Asp-box motif; other site 585035007295 catalytic site [active] 585035007296 Catalytic domain of bacteriophage endosialidase; Region: End_tail_spike; pfam12219 585035007297 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 585035007298 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 585035007299 Phage anti-repressor protein [Transcription]; Region: COG3561 585035007300 Mnt; Region: mnt; PHA01513 585035007301 Arc-like DNA binding domain; Region: Arc; pfam03869 585035007302 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 585035007303 active site 585035007304 Toxin YafO, type II toxin-antitoxin system; Region: YafO_toxin; pfam13957 585035007305 Protein of unknown function (DUF2824); Region: DUF2824; pfam11039 585035007306 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 585035007307 P22 tail accessory factor; Region: P22_Tail-4; pfam11650 585035007308 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 585035007309 coat protein; Region: PHA01511 585035007310 Phage terminase large subunit; Region: Terminase_3; pfam04466 585035007311 Protein of unknown function (DUF2560); Region: DUF2560; pfam10834 585035007312 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 585035007313 ORF11CD3 domain; Region: ORF11CD3; pfam10549 585035007314 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585035007315 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 585035007316 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585035007317 catalytic residue [active] 585035007318 phage holin, lambda family; Region: holin_lambda; TIGR01594 585035007319 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 585035007320 Phage NinH protein; Region: Phage_NinH; pfam06322 585035007321 Endodeoxyribonuclease RusA; Region: RusA; cl01885 585035007322 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 585035007323 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 585035007324 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 585035007325 NinF protein; Region: NinF; pfam05810 585035007326 Protein of unknown function (DUF2591); Region: DUF2591; pfam10765 585035007327 NinB protein; Region: NinB; pfam05772 585035007328 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 585035007329 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 585035007330 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 585035007331 Walker A motif; other site 585035007332 ATP binding site [chemical binding]; other site 585035007333 Walker B motif; other site 585035007334 DNA binding loops [nucleotide binding] 585035007335 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 585035007336 Bacteriophage CII protein; Region: Phage_CII; pfam05269 585035007337 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 585035007338 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 585035007339 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585035007340 non-specific DNA binding site [nucleotide binding]; other site 585035007341 salt bridge; other site 585035007342 sequence-specific DNA binding site [nucleotide binding]; other site 585035007343 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585035007344 Catalytic site [active] 585035007345 ERF superfamily; Region: ERF; pfam04404 585035007346 Protein of unknown function (DUF2856); Region: DUF2856; pfam11043 585035007347 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 585035007348 Protein of unknown function (DUF551); Region: DUF551; pfam04448 585035007349 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 585035007350 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 585035007351 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 585035007352 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035007353 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 585035007354 dimerization interface [polypeptide binding]; other site 585035007355 substrate binding pocket [chemical binding]; other site 585035007356 permease DsdX; Provisional; Region: PRK09921 585035007357 gluconate transporter; Region: gntP; TIGR00791 585035007358 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 585035007359 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 585035007360 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585035007361 catalytic residue [active] 585035007362 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 585035007363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035007364 putative substrate translocation pore; other site 585035007365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035007366 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 585035007367 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585035007368 HlyD family secretion protein; Region: HlyD_3; pfam13437 585035007369 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 585035007370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035007371 active site 585035007372 phosphorylation site [posttranslational modification] 585035007373 intermolecular recognition site; other site 585035007374 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585035007375 DNA binding residues [nucleotide binding] 585035007376 dimerization interface [polypeptide binding]; other site 585035007377 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 585035007378 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585035007379 substrate binding pocket [chemical binding]; other site 585035007380 membrane-bound complex binding site; other site 585035007381 hinge residues; other site 585035007382 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585035007383 substrate binding pocket [chemical binding]; other site 585035007384 membrane-bound complex binding site; other site 585035007385 hinge residues; other site 585035007386 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585035007387 dimer interface [polypeptide binding]; other site 585035007388 phosphorylation site [posttranslational modification] 585035007389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035007390 ATP binding site [chemical binding]; other site 585035007391 Mg2+ binding site [ion binding]; other site 585035007392 G-X-G motif; other site 585035007393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035007394 active site 585035007395 phosphorylation site [posttranslational modification] 585035007396 intermolecular recognition site; other site 585035007397 dimerization interface [polypeptide binding]; other site 585035007398 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 585035007399 putative binding surface; other site 585035007400 active site 585035007401 putative CoA-transferase; Provisional; Region: PRK11430 585035007402 CoA-transferase family III; Region: CoA_transf_3; pfam02515 585035007403 putative transporter YfdV; Provisional; Region: PRK09903 585035007404 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 585035007405 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 585035007406 PYR/PP interface [polypeptide binding]; other site 585035007407 dimer interface [polypeptide binding]; other site 585035007408 TPP binding site [chemical binding]; other site 585035007409 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 585035007410 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 585035007411 TPP-binding site; other site 585035007412 dimer interface [polypeptide binding]; other site 585035007413 formyl-coenzyme A transferase; Provisional; Region: PRK05398 585035007414 CoA-transferase family III; Region: CoA_transf_3; pfam02515 585035007415 hypothetical protein; Provisional; Region: PRK10316 585035007416 YfdX protein; Region: YfdX; pfam10938 585035007417 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 585035007418 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 585035007419 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 585035007420 putative acyl-acceptor binding pocket; other site 585035007421 aminotransferase; Validated; Region: PRK08175 585035007422 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585035007423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035007424 homodimer interface [polypeptide binding]; other site 585035007425 catalytic residue [active] 585035007426 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 585035007427 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 585035007428 GAF domain; Region: GAF; cl17456 585035007429 Histidine kinase; Region: His_kinase; pfam06580 585035007430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035007431 ATP binding site [chemical binding]; other site 585035007432 Mg2+ binding site [ion binding]; other site 585035007433 G-X-G motif; other site 585035007434 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 585035007435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035007436 active site 585035007437 phosphorylation site [posttranslational modification] 585035007438 intermolecular recognition site; other site 585035007439 dimerization interface [polypeptide binding]; other site 585035007440 LytTr DNA-binding domain; Region: LytTR; pfam04397 585035007441 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585035007442 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035007443 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585035007444 dimerization domain swap beta strand [polypeptide binding]; other site 585035007445 regulatory protein interface [polypeptide binding]; other site 585035007446 active site 585035007447 regulatory phosphorylation site [posttranslational modification]; other site 585035007448 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 585035007449 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 585035007450 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 585035007451 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 585035007452 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585035007453 active site 585035007454 phosphorylation site [posttranslational modification] 585035007455 exoaminopeptidase; Provisional; Region: PRK09961 585035007456 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 585035007457 oligomer interface [polypeptide binding]; other site 585035007458 active site 585035007459 metal binding site [ion binding]; metal-binding site 585035007460 aminopeptidase; Provisional; Region: PRK09795 585035007461 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 585035007462 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 585035007463 active site 585035007464 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 585035007465 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 585035007466 active site 585035007467 P-loop; other site 585035007468 phosphorylation site [posttranslational modification] 585035007469 glucokinase, proteobacterial type; Region: glk; TIGR00749 585035007470 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585035007471 nucleotide binding site [chemical binding]; other site 585035007472 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 585035007473 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 585035007474 Cl- selectivity filter; other site 585035007475 Cl- binding residues [ion binding]; other site 585035007476 pore gating glutamate residue; other site 585035007477 dimer interface [polypeptide binding]; other site 585035007478 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 585035007479 manganese transport protein MntH; Reviewed; Region: PRK00701 585035007480 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 585035007481 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 585035007482 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 585035007483 Nucleoside recognition; Region: Gate; pfam07670 585035007484 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 585035007485 MASE1; Region: MASE1; pfam05231 585035007486 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585035007487 diguanylate cyclase; Region: GGDEF; smart00267 585035007488 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585035007489 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 585035007490 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585035007491 salt bridge; other site 585035007492 non-specific DNA binding site [nucleotide binding]; other site 585035007493 sequence-specific DNA binding site [nucleotide binding]; other site 585035007494 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 585035007495 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 585035007496 active site 585035007497 HIGH motif; other site 585035007498 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 585035007499 active site 585035007500 KMSKS motif; other site 585035007501 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 585035007502 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035007503 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 585035007504 putative dimerization interface [polypeptide binding]; other site 585035007505 putative substrate binding pocket [chemical binding]; other site 585035007506 nucleoside transporter; Region: 2A0110; TIGR00889 585035007507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035007508 putative substrate translocation pore; other site 585035007509 purine nucleoside phosphorylase; Provisional; Region: PRK08202 585035007510 hypothetical protein; Provisional; Region: PRK11528 585035007511 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585035007512 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035007513 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 585035007514 putative dimerization interface [polypeptide binding]; other site 585035007515 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 585035007516 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 585035007517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 585035007518 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 585035007519 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 585035007520 nucleotide binding pocket [chemical binding]; other site 585035007521 K-X-D-G motif; other site 585035007522 catalytic site [active] 585035007523 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 585035007524 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 585035007525 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 585035007526 Dimer interface [polypeptide binding]; other site 585035007527 BRCT sequence motif; other site 585035007528 cell division protein ZipA; Provisional; Region: PRK03427 585035007529 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 585035007530 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 585035007531 FtsZ protein binding site [polypeptide binding]; other site 585035007532 putative sulfate transport protein CysZ; Validated; Region: PRK04949 585035007533 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 585035007534 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 585035007535 dimer interface [polypeptide binding]; other site 585035007536 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035007537 catalytic residue [active] 585035007538 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585035007539 dimerization domain swap beta strand [polypeptide binding]; other site 585035007540 regulatory protein interface [polypeptide binding]; other site 585035007541 active site 585035007542 regulatory phosphorylation site [posttranslational modification]; other site 585035007543 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 585035007544 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 585035007545 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 585035007546 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 585035007547 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 585035007548 HPr interaction site; other site 585035007549 glycerol kinase (GK) interaction site [polypeptide binding]; other site 585035007550 active site 585035007551 phosphorylation site [posttranslational modification] 585035007552 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 585035007553 dimer interface [polypeptide binding]; other site 585035007554 pyridoxamine kinase; Validated; Region: PRK05756 585035007555 pyridoxal binding site [chemical binding]; other site 585035007556 ATP binding site [chemical binding]; other site 585035007557 hypothetical protein; Provisional; Region: PRK10318 585035007558 cysteine synthase B; Region: cysM; TIGR01138 585035007559 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 585035007560 dimer interface [polypeptide binding]; other site 585035007561 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035007562 catalytic residue [active] 585035007563 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 585035007564 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 585035007565 Walker A/P-loop; other site 585035007566 ATP binding site [chemical binding]; other site 585035007567 Q-loop/lid; other site 585035007568 ABC transporter signature motif; other site 585035007569 Walker B; other site 585035007570 D-loop; other site 585035007571 H-loop/switch region; other site 585035007572 TOBE-like domain; Region: TOBE_3; pfam12857 585035007573 sulfate transport protein; Provisional; Region: cysT; CHL00187 585035007574 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035007575 dimer interface [polypeptide binding]; other site 585035007576 conserved gate region; other site 585035007577 putative PBP binding loops; other site 585035007578 ABC-ATPase subunit interface; other site 585035007579 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 585035007580 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035007581 dimer interface [polypeptide binding]; other site 585035007582 conserved gate region; other site 585035007583 putative PBP binding loops; other site 585035007584 ABC-ATPase subunit interface; other site 585035007585 thiosulfate transporter subunit; Provisional; Region: PRK10852 585035007586 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 585035007587 short chain dehydrogenase; Provisional; Region: PRK08226 585035007588 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 585035007589 NAD binding site [chemical binding]; other site 585035007590 homotetramer interface [polypeptide binding]; other site 585035007591 homodimer interface [polypeptide binding]; other site 585035007592 active site 585035007593 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 585035007594 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 585035007595 putative active site [active] 585035007596 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 585035007597 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585035007598 active site turn [active] 585035007599 phosphorylation site [posttranslational modification] 585035007600 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 585035007601 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 585035007602 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 585035007603 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 585035007604 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 585035007605 putative acetyltransferase; Provisional; Region: PRK03624 585035007606 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585035007607 Coenzyme A binding pocket [chemical binding]; other site 585035007608 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 585035007609 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 585035007610 active site 585035007611 metal binding site [ion binding]; metal-binding site 585035007612 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 585035007613 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 585035007614 transcriptional regulator EutR; Provisional; Region: PRK10130 585035007615 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035007616 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035007617 carboxysome structural protein EutK; Provisional; Region: PRK15466 585035007618 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 585035007619 Hexamer interface [polypeptide binding]; other site 585035007620 Hexagonal pore residue; other site 585035007621 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 585035007622 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 585035007623 putative hexamer interface [polypeptide binding]; other site 585035007624 putative hexagonal pore; other site 585035007625 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 585035007626 putative hexamer interface [polypeptide binding]; other site 585035007627 putative hexagonal pore; other site 585035007628 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 585035007629 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 585035007630 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 585035007631 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 585035007632 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 585035007633 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 585035007634 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 585035007635 active site 585035007636 metal binding site [ion binding]; metal-binding site 585035007637 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 585035007638 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585035007639 nucleotide binding site [chemical binding]; other site 585035007640 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 585035007641 putative catalytic cysteine [active] 585035007642 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 585035007643 Hexamer/Pentamer interface [polypeptide binding]; other site 585035007644 central pore; other site 585035007645 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7868611; Product type f : factor 585035007646 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 585035007647 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 585035007648 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 585035007649 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 585035007650 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 585035007651 G1 box; other site 585035007652 GTP/Mg2+ binding site [chemical binding]; other site 585035007653 G2 box; other site 585035007654 Switch I region; other site 585035007655 G3 box; other site 585035007656 Switch II region; other site 585035007657 G4 box; other site 585035007658 G5 box; other site 585035007659 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 585035007660 putative hexamer interface [polypeptide binding]; other site 585035007661 putative hexagonal pore; other site 585035007662 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 585035007663 Malic enzyme, N-terminal domain; Region: malic; pfam00390 585035007664 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 585035007665 putative NAD(P) binding site [chemical binding]; other site 585035007666 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 585035007667 transaldolase-like protein; Provisional; Region: PTZ00411 585035007668 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 585035007669 active site 585035007670 dimer interface [polypeptide binding]; other site 585035007671 catalytic residue [active] 585035007672 transketolase; Reviewed; Region: PRK12753 585035007673 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 585035007674 TPP-binding site [chemical binding]; other site 585035007675 dimer interface [polypeptide binding]; other site 585035007676 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 585035007677 PYR/PP interface [polypeptide binding]; other site 585035007678 dimer interface [polypeptide binding]; other site 585035007679 TPP binding site [chemical binding]; other site 585035007680 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 585035007681 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 585035007682 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 585035007683 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 585035007684 dimer interface [polypeptide binding]; other site 585035007685 ADP-ribose binding site [chemical binding]; other site 585035007686 active site 585035007687 nudix motif; other site 585035007688 metal binding site [ion binding]; metal-binding site 585035007689 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 585035007690 4Fe-4S binding domain; Region: Fer4; pfam00037 585035007691 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 585035007692 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585035007693 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 585035007694 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 585035007695 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585035007696 dimerization interface [polypeptide binding]; other site 585035007697 Histidine kinase; Region: HisKA_3; pfam07730 585035007698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035007699 ATP binding site [chemical binding]; other site 585035007700 Mg2+ binding site [ion binding]; other site 585035007701 G-X-G motif; other site 585035007702 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 585035007703 Protein export membrane protein; Region: SecD_SecF; cl14618 585035007704 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 585035007705 ArsC family; Region: ArsC; pfam03960 585035007706 putative catalytic residues [active] 585035007707 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 585035007708 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 585035007709 metal binding site [ion binding]; metal-binding site 585035007710 dimer interface [polypeptide binding]; other site 585035007711 hypothetical protein; Provisional; Region: PRK13664 585035007712 putative hydrolase; Provisional; Region: PRK11460 585035007713 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 585035007714 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 585035007715 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 585035007716 Helicase; Region: Helicase_RecD; pfam05127 585035007717 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 585035007718 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 585035007719 Predicted metalloprotease [General function prediction only]; Region: COG2321 585035007720 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 585035007721 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 585035007722 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 585035007723 ATP binding site [chemical binding]; other site 585035007724 active site 585035007725 substrate binding site [chemical binding]; other site 585035007726 lipoprotein; Provisional; Region: PRK11679 585035007727 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 585035007728 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 585035007729 dihydrodipicolinate synthase; Region: dapA; TIGR00674 585035007730 dimer interface [polypeptide binding]; other site 585035007731 active site 585035007732 catalytic residue [active] 585035007733 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 585035007734 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 585035007735 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 585035007736 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 585035007737 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 585035007738 catalytic triad [active] 585035007739 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 585035007740 Domain of unknown function DUF20; Region: UPF0118; pfam01594 585035007741 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 585035007742 Peptidase family M48; Region: Peptidase_M48; cl12018 585035007743 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 585035007744 ArsC family; Region: ArsC; pfam03960 585035007745 catalytic residues [active] 585035007746 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 585035007747 DNA replication initiation factor; Provisional; Region: PRK08084 585035007748 uracil transporter; Provisional; Region: PRK10720 585035007749 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585035007750 active site 585035007751 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 585035007752 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 585035007753 dimerization interface [polypeptide binding]; other site 585035007754 putative ATP binding site [chemical binding]; other site 585035007755 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 585035007756 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 585035007757 active site 585035007758 substrate binding site [chemical binding]; other site 585035007759 cosubstrate binding site; other site 585035007760 catalytic site [active] 585035007761 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 585035007762 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 585035007763 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 585035007764 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 585035007765 domain interface [polypeptide binding]; other site 585035007766 active site 585035007767 catalytic site [active] 585035007768 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 585035007769 putative active site [active] 585035007770 catalytic site [active] 585035007771 exopolyphosphatase; Provisional; Region: PRK10854 585035007772 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 585035007773 MASE1; Region: MASE1; pfam05231 585035007774 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 585035007775 diguanylate cyclase; Region: GGDEF; smart00267 585035007776 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585035007777 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 585035007778 GMP synthase; Reviewed; Region: guaA; PRK00074 585035007779 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 585035007780 AMP/PPi binding site [chemical binding]; other site 585035007781 candidate oxyanion hole; other site 585035007782 catalytic triad [active] 585035007783 potential glutamine specificity residues [chemical binding]; other site 585035007784 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 585035007785 ATP Binding subdomain [chemical binding]; other site 585035007786 Ligand Binding sites [chemical binding]; other site 585035007787 Dimerization subdomain; other site 585035007788 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 585035007789 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 585035007790 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 585035007791 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 585035007792 active site 585035007793 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 585035007794 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 585035007795 generic binding surface II; other site 585035007796 generic binding surface I; other site 585035007797 RatA-like protein; Provisional; Region: PRK15316 585035007798 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 585035007799 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 585035007800 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 585035007801 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 585035007802 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 585035007803 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 585035007804 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 585035007805 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 585035007806 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 585035007807 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 585035007808 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 585035007809 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 585035007810 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 585035007811 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 585035007812 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 585035007813 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 585035007814 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 585035007815 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 585035007816 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component 585035007817 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component 585035007818 intimin-like protein SinH; Provisional; Region: PRK15318 585035007819 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 585035007820 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 585035007821 GTP-binding protein Der; Reviewed; Region: PRK00093 585035007822 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 585035007823 G1 box; other site 585035007824 GTP/Mg2+ binding site [chemical binding]; other site 585035007825 Switch I region; other site 585035007826 G2 box; other site 585035007827 Switch II region; other site 585035007828 G3 box; other site 585035007829 G4 box; other site 585035007830 G5 box; other site 585035007831 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 585035007832 G1 box; other site 585035007833 GTP/Mg2+ binding site [chemical binding]; other site 585035007834 Switch I region; other site 585035007835 G2 box; other site 585035007836 G3 box; other site 585035007837 Switch II region; other site 585035007838 G4 box; other site 585035007839 G5 box; other site 585035007840 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 585035007841 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 585035007842 Trp docking motif [polypeptide binding]; other site 585035007843 active site 585035007844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 585035007845 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 585035007846 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 585035007847 dimer interface [polypeptide binding]; other site 585035007848 motif 1; other site 585035007849 active site 585035007850 motif 2; other site 585035007851 motif 3; other site 585035007852 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 585035007853 anticodon binding site; other site 585035007854 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 585035007855 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 585035007856 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 585035007857 cytoskeletal protein RodZ; Provisional; Region: PRK10856 585035007858 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585035007859 non-specific DNA binding site [nucleotide binding]; other site 585035007860 salt bridge; other site 585035007861 sequence-specific DNA binding site [nucleotide binding]; other site 585035007862 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 585035007863 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 585035007864 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585035007865 FeS/SAM binding site; other site 585035007866 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 585035007867 active site 585035007868 multimer interface [polypeptide binding]; other site 585035007869 penicillin-binding protein 1C; Provisional; Region: PRK11240 585035007870 Transglycosylase; Region: Transgly; pfam00912 585035007871 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 585035007872 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 585035007873 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 585035007874 MG2 domain; Region: A2M_N; pfam01835 585035007875 Alpha-2-macroglobulin family; Region: A2M; pfam00207 585035007876 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 585035007877 surface patch; other site 585035007878 thioester region; other site 585035007879 specificity defining residues; other site 585035007880 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 585035007881 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 585035007882 active site residue [active] 585035007883 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 585035007884 active site residue [active] 585035007885 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 585035007886 aminopeptidase B; Provisional; Region: PRK05015 585035007887 Peptidase; Region: DUF3663; pfam12404 585035007888 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 585035007889 interface (dimer of trimers) [polypeptide binding]; other site 585035007890 Substrate-binding/catalytic site; other site 585035007891 Zn-binding sites [ion binding]; other site 585035007892 hypothetical protein; Provisional; Region: PRK10721 585035007893 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 585035007894 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585035007895 catalytic loop [active] 585035007896 iron binding site [ion binding]; other site 585035007897 chaperone protein HscA; Provisional; Region: hscA; PRK05183 585035007898 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 585035007899 nucleotide binding site [chemical binding]; other site 585035007900 putative NEF/HSP70 interaction site [polypeptide binding]; other site 585035007901 SBD interface [polypeptide binding]; other site 585035007902 co-chaperone HscB; Provisional; Region: hscB; PRK05014 585035007903 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 585035007904 HSP70 interaction site [polypeptide binding]; other site 585035007905 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 585035007906 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 585035007907 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 585035007908 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 585035007909 trimerization site [polypeptide binding]; other site 585035007910 active site 585035007911 cysteine desulfurase; Provisional; Region: PRK14012 585035007912 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 585035007913 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585035007914 catalytic residue [active] 585035007915 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 585035007916 Rrf2 family protein; Region: rrf2_super; TIGR00738 585035007917 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 585035007918 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 585035007919 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 585035007920 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 585035007921 active site 585035007922 dimerization interface [polypeptide binding]; other site 585035007923 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 585035007924 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 585035007925 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 585035007926 PRD domain; Region: PRD; pfam00874 585035007927 PRD domain; Region: PRD; pfam00874 585035007928 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 585035007929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035007930 putative substrate translocation pore; other site 585035007931 Predicted membrane protein [Function unknown]; Region: COG2259 585035007932 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 585035007933 active site 585035007934 catalytic residues [active] 585035007935 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 585035007936 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 585035007937 putative NAD(P) binding site [chemical binding]; other site 585035007938 catalytic Zn binding site [ion binding]; other site 585035007939 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585035007940 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585035007941 TM-ABC transporter signature motif; other site 585035007942 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 585035007943 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585035007944 Walker A/P-loop; other site 585035007945 ATP binding site [chemical binding]; other site 585035007946 Q-loop/lid; other site 585035007947 ABC transporter signature motif; other site 585035007948 Walker B; other site 585035007949 D-loop; other site 585035007950 H-loop/switch region; other site 585035007951 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585035007952 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 585035007953 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 585035007954 ligand binding site [chemical binding]; other site 585035007955 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585035007956 TPR motif; other site 585035007957 Tetratricopeptide repeat; Region: TPR_16; pfam13432 585035007958 binding surface 585035007959 TPR repeat; Region: TPR_11; pfam13414 585035007960 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585035007961 TPR motif; other site 585035007962 binding surface 585035007963 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 585035007964 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 585035007965 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585035007966 nucleotide binding site [chemical binding]; other site 585035007967 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 585035007968 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 585035007969 dimer interface [polypeptide binding]; other site 585035007970 active site 585035007971 glycine-pyridoxal phosphate binding site [chemical binding]; other site 585035007972 folate binding site [chemical binding]; other site 585035007973 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 585035007974 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 585035007975 heme-binding site [chemical binding]; other site 585035007976 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 585035007977 FAD binding pocket [chemical binding]; other site 585035007978 FAD binding motif [chemical binding]; other site 585035007979 phosphate binding motif [ion binding]; other site 585035007980 beta-alpha-beta structure motif; other site 585035007981 NAD binding pocket [chemical binding]; other site 585035007982 Heme binding pocket [chemical binding]; other site 585035007983 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 585035007984 Nitrogen regulatory protein P-II; Region: P-II; smart00938 585035007985 response regulator GlrR; Provisional; Region: PRK15115 585035007986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035007987 active site 585035007988 phosphorylation site [posttranslational modification] 585035007989 intermolecular recognition site; other site 585035007990 dimerization interface [polypeptide binding]; other site 585035007991 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035007992 Walker A motif; other site 585035007993 ATP binding site [chemical binding]; other site 585035007994 Walker B motif; other site 585035007995 arginine finger; other site 585035007996 hypothetical protein; Provisional; Region: PRK10722 585035007997 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 585035007998 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585035007999 dimer interface [polypeptide binding]; other site 585035008000 phosphorylation site [posttranslational modification] 585035008001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035008002 ATP binding site [chemical binding]; other site 585035008003 Mg2+ binding site [ion binding]; other site 585035008004 G-X-G motif; other site 585035008005 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 585035008006 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 585035008007 dimerization interface [polypeptide binding]; other site 585035008008 ATP binding site [chemical binding]; other site 585035008009 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 585035008010 dimerization interface [polypeptide binding]; other site 585035008011 ATP binding site [chemical binding]; other site 585035008012 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 585035008013 putative active site [active] 585035008014 catalytic triad [active] 585035008015 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 585035008016 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585035008017 substrate binding pocket [chemical binding]; other site 585035008018 membrane-bound complex binding site; other site 585035008019 hinge residues; other site 585035008020 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585035008021 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585035008022 catalytic residue [active] 585035008023 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 585035008024 nucleoside/Zn binding site; other site 585035008025 dimer interface [polypeptide binding]; other site 585035008026 catalytic motif [active] 585035008027 hypothetical protein; Provisional; Region: PRK11590 585035008028 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 585035008029 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 585035008030 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 585035008031 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 585035008032 putative active site [active] 585035008033 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 585035008034 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 585035008035 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 585035008036 active site 585035008037 hydrophilic channel; other site 585035008038 dimerization interface [polypeptide binding]; other site 585035008039 catalytic residues [active] 585035008040 active site lid [active] 585035008041 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 585035008042 Recombination protein O N terminal; Region: RecO_N; pfam11967 585035008043 Recombination protein O C terminal; Region: RecO_C; pfam02565 585035008044 GTPase Era; Reviewed; Region: era; PRK00089 585035008045 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 585035008046 G1 box; other site 585035008047 GTP/Mg2+ binding site [chemical binding]; other site 585035008048 Switch I region; other site 585035008049 G2 box; other site 585035008050 Switch II region; other site 585035008051 G3 box; other site 585035008052 G4 box; other site 585035008053 G5 box; other site 585035008054 KH domain; Region: KH_2; pfam07650 585035008055 ribonuclease III; Reviewed; Region: rnc; PRK00102 585035008056 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 585035008057 dimerization interface [polypeptide binding]; other site 585035008058 active site 585035008059 metal binding site [ion binding]; metal-binding site 585035008060 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 585035008061 dsRNA binding site [nucleotide binding]; other site 585035008062 signal peptidase I; Provisional; Region: PRK10861 585035008063 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 585035008064 Catalytic site [active] 585035008065 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 585035008066 GTP-binding protein LepA; Provisional; Region: PRK05433 585035008067 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 585035008068 G1 box; other site 585035008069 putative GEF interaction site [polypeptide binding]; other site 585035008070 GTP/Mg2+ binding site [chemical binding]; other site 585035008071 Switch I region; other site 585035008072 G2 box; other site 585035008073 G3 box; other site 585035008074 Switch II region; other site 585035008075 G4 box; other site 585035008076 G5 box; other site 585035008077 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 585035008078 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 585035008079 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 585035008080 SoxR reducing system protein RseC; Provisional; Region: PRK10862 585035008081 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 585035008082 anti-sigma E factor; Provisional; Region: rseB; PRK09455 585035008083 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 585035008084 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 585035008085 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 585035008086 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 585035008087 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 585035008088 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585035008089 DNA binding residues [nucleotide binding] 585035008090 L-aspartate oxidase; Provisional; Region: PRK09077 585035008091 L-aspartate oxidase; Provisional; Region: PRK06175 585035008092 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 585035008093 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 585035008094 Methyltransferase domain; Region: Methyltransf_26; pfam13659 585035008095 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 585035008096 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 585035008097 ATP binding site [chemical binding]; other site 585035008098 Mg++ binding site [ion binding]; other site 585035008099 motif III; other site 585035008100 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585035008101 nucleotide binding region [chemical binding]; other site 585035008102 ATP-binding site [chemical binding]; other site 585035008103 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585035008104 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035008105 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 585035008106 dimerization interface [polypeptide binding]; other site 585035008107 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 585035008108 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 585035008109 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 585035008110 ligand binding site [chemical binding]; other site 585035008111 active site 585035008112 UGI interface [polypeptide binding]; other site 585035008113 catalytic site [active] 585035008114 putative methyltransferase; Provisional; Region: PRK10864 585035008115 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 585035008116 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 585035008117 thioredoxin 2; Provisional; Region: PRK10996 585035008118 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 585035008119 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 585035008120 catalytic residues [active] 585035008121 Uncharacterized conserved protein [Function unknown]; Region: COG3148 585035008122 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 585035008123 CoA binding domain; Region: CoA_binding_2; pfam13380 585035008124 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 585035008125 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 585035008126 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 585035008127 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 585035008128 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 585035008129 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 585035008130 domain interface [polypeptide binding]; other site 585035008131 putative active site [active] 585035008132 catalytic site [active] 585035008133 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 585035008134 domain interface [polypeptide binding]; other site 585035008135 putative active site [active] 585035008136 catalytic site [active] 585035008137 lipoprotein; Provisional; Region: PRK10759 585035008138 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 585035008139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035008140 putative substrate translocation pore; other site 585035008141 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585035008142 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 585035008143 DNA binding residues [nucleotide binding] 585035008144 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 585035008145 Integrase core domain; Region: rve; pfam00665 585035008146 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 585035008147 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 585035008148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035008149 Walker A motif; other site 585035008150 ATP binding site [chemical binding]; other site 585035008151 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme 585035008152 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme 585035008153 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme 585035008154 HTH-like domain; Region: HTH_21; pfam13276 585035008155 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 585035008156 Integrase core domain; Region: rve; pfam00665 585035008157 Integrase core domain; Region: rve_2; pfam13333 585035008158 Evidence 7 : Gene remnant; Product type pe : enzyme 585035008159 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 585035008160 protein disaggregation chaperone; Provisional; Region: PRK10865 585035008161 Clp amino terminal domain; Region: Clp_N; pfam02861 585035008162 Clp amino terminal domain; Region: Clp_N; pfam02861 585035008163 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035008164 Walker A motif; other site 585035008165 ATP binding site [chemical binding]; other site 585035008166 Walker B motif; other site 585035008167 arginine finger; other site 585035008168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035008169 Walker A motif; other site 585035008170 ATP binding site [chemical binding]; other site 585035008171 Walker B motif; other site 585035008172 arginine finger; other site 585035008173 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 585035008174 hypothetical protein; Provisional; Region: PRK10723 585035008175 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 585035008176 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 585035008177 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585035008178 RNA binding surface [nucleotide binding]; other site 585035008179 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 585035008180 active site 585035008181 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 585035008182 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 585035008183 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 585035008184 30S subunit binding site; other site 585035008185 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 585035008186 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 585035008187 Prephenate dehydratase; Region: PDT; pfam00800 585035008188 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 585035008189 putative L-Phe binding site [chemical binding]; other site 585035008190 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 585035008191 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 585035008192 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 585035008193 prephenate dehydrogenase; Validated; Region: PRK08507 585035008194 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 585035008195 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 585035008196 lipoprotein; Provisional; Region: PRK11443 585035008197 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 585035008198 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 585035008199 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 585035008200 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585035008201 metal binding site [ion binding]; metal-binding site 585035008202 active site 585035008203 I-site; other site 585035008204 putative outer membrane lipoprotein; Provisional; Region: PRK09967 585035008205 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585035008206 ligand binding site [chemical binding]; other site 585035008207 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 585035008208 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 585035008209 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 585035008210 RimM N-terminal domain; Region: RimM; pfam01782 585035008211 PRC-barrel domain; Region: PRC; pfam05239 585035008212 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 585035008213 signal recognition particle protein; Provisional; Region: PRK10867 585035008214 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 585035008215 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 585035008216 P loop; other site 585035008217 GTP binding site [chemical binding]; other site 585035008218 Signal peptide binding domain; Region: SRP_SPB; pfam02978 585035008219 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 585035008220 hypothetical protein; Provisional; Region: PRK11573 585035008221 Domain of unknown function DUF21; Region: DUF21; pfam01595 585035008222 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 585035008223 Transporter associated domain; Region: CorC_HlyC; smart01091 585035008224 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 585035008225 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 585035008226 dimer interface [polypeptide binding]; other site 585035008227 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 585035008228 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 585035008229 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 585035008230 recombination and repair protein; Provisional; Region: PRK10869 585035008231 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 585035008232 Walker A/P-loop; other site 585035008233 ATP binding site [chemical binding]; other site 585035008234 Q-loop/lid; other site 585035008235 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 585035008236 Q-loop/lid; other site 585035008237 ABC transporter signature motif; other site 585035008238 Walker B; other site 585035008239 D-loop; other site 585035008240 H-loop/switch region; other site 585035008241 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 585035008242 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 585035008243 hypothetical protein; Validated; Region: PRK01777 585035008244 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 585035008245 putative coenzyme Q binding site [chemical binding]; other site 585035008246 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 585035008247 SmpB-tmRNA interface; other site 585035008248 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 585035008249 tail protein; Provisional; Region: D; PHA02561 585035008250 Phage protein U [General function prediction only]; Region: COG3499 585035008251 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 585035008252 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 585035008253 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 585035008254 major tail tube protein; Provisional; Region: FII; PHA02600 585035008255 major tail sheath protein; Provisional; Region: FI; PHA02560 585035008256 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 585035008257 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 585035008258 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 585035008259 Phage Tail Collar Domain; Region: Collar; pfam07484 585035008260 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 585035008261 baseplate assembly protein; Provisional; Region: J; PHA02568 585035008262 baseplate wedge subunit; Provisional; Region: W; PHA02516 585035008263 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 585035008264 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 585035008265 AIPR protein; Region: AIPR; pfam10592 585035008266 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 585035008267 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 585035008268 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 585035008269 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585035008270 catalytic residues [active] 585035008271 P2-like prophage tail protein X [General function prediction only]; Region: COG5004 585035008272 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 585035008273 terminase endonuclease subunit; Provisional; Region: M; PHA02537 585035008274 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 585035008275 capsid protein; Provisional; Region: N; PHA02538 585035008276 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929 585035008277 terminase ATPase subunit; Provisional; Region: P; PHA02535 585035008278 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 585035008279 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 585035008280 portal vertex protein; Provisional; Region: Q; PHA02536 585035008281 Phage portal protein; Region: Phage_portal; pfam04860 585035008282 DinI-like family; Region: DinI; pfam06183 585035008283 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 585035008284 DNA adenine methylase (dam); Region: dam; TIGR00571 585035008285 DksA-like zinc finger domain containing protein; Region: PHA00080 585035008286 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 585035008287 Protein of unknown function (DUF2724); Region: DUF2724; pfam10893 585035008288 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 585035008289 Predicted transcriptional regulator [Transcription]; Region: COG2932 585035008290 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 585035008291 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585035008292 Catalytic site [active] 585035008293 integrase; Provisional; Region: int; PHA02601 585035008294 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 585035008295 active site 585035008296 DNA binding site [nucleotide binding] 585035008297 Int/Topo IB signature motif; other site 585035008298 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 585035008299 GIY-YIG motif/motif A; other site 585035008300 putative active site [active] 585035008301 putative metal binding site [ion binding]; other site 585035008302 DinI-like family; Region: DinI; cl11630 585035008303 Uncharacterized conserved protein [Function unknown]; Region: COG1479 585035008304 Protein of unknown function DUF262; Region: DUF262; pfam03235 585035008305 Protein of unknown function DUF262; Region: DUF262; pfam03235 585035008306 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 585035008307 Evidence 2b : Function of strongly homologous gene; PubMedId : 6310572, 3894006; Product type e : enzyme 585035008308 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 585035008309 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 585035008310 Phage Tail Collar Domain; Region: Collar; pfam07484 585035008311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3778 585035008312 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 585035008313 Phage protein GP46; Region: GP46; pfam07409 585035008314 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 585035008315 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; pfam06890 585035008316 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 585035008317 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 585035008318 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 585035008319 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 585035008320 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 585035008321 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 585035008322 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 585035008323 Phage tail tube protein; Region: Tail_tube; pfam10618 585035008324 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 585035008325 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 585035008326 Protein of unknown function (DUF2635); Region: DUF2635; pfam10948 585035008327 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 585035008328 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 585035008329 oligomerization interface [polypeptide binding]; other site 585035008330 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 585035008331 Phage capsid family; Region: Phage_capsid; pfam05065 585035008332 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 585035008333 Phage-related protein [Function unknown]; Region: COG4695 585035008334 Phage portal protein; Region: Phage_portal; pfam04860 585035008335 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 585035008336 Phage terminase, small subunit; Region: Terminase_4; pfam05119 585035008337 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 585035008338 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 585035008339 active site 585035008340 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585035008341 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 585035008342 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585035008343 catalytic residue [active] 585035008344 Antitermination protein; Region: Antiterm; pfam03589 585035008345 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 585035008346 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 585035008347 Zn binding sites [ion binding]; other site 585035008348 Antitermination protein; Region: Antiterm; pfam03589 585035008349 Protein of unknown function (DUF968); Region: DUF968; pfam06147 585035008350 KilA-N domain; Region: KilA-N; pfam04383 585035008351 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 585035008352 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 585035008353 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 585035008354 PerC transcriptional activator; Region: PerC; pfam06069 585035008355 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585035008356 DNA-binding site [nucleotide binding]; DNA binding site 585035008357 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 585035008358 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585035008359 Catalytic site [active] 585035008360 Uncharacterized conserved protein [Function unknown]; Region: COG5532 585035008361 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 585035008362 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 585035008363 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 585035008364 Int/Topo IB signature motif; other site 585035008365 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 585035008366 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 585035008367 substrate binding pocket [chemical binding]; other site 585035008368 active site 585035008369 iron coordination sites [ion binding]; other site 585035008370 Predicted dehydrogenase [General function prediction only]; Region: COG0579 585035008371 hydroxyglutarate oxidase; Provisional; Region: PRK11728 585035008372 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 585035008373 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 585035008374 tetramerization interface [polypeptide binding]; other site 585035008375 NAD(P) binding site [chemical binding]; other site 585035008376 catalytic residues [active] 585035008377 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 585035008378 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585035008379 inhibitor-cofactor binding pocket; inhibition site 585035008380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035008381 catalytic residue [active] 585035008382 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 585035008383 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 585035008384 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585035008385 DNA-binding site [nucleotide binding]; DNA binding site 585035008386 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585035008387 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 585035008388 bacterial OsmY and nodulation domain; Region: BON; smart00749 585035008389 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585035008390 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 585035008391 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585035008392 dimerization interface [polypeptide binding]; other site 585035008393 putative DNA binding site [nucleotide binding]; other site 585035008394 Transcriptional regulators [Transcription]; Region: MarR; COG1846 585035008395 putative Zn2+ binding site [ion binding]; other site 585035008396 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 585035008397 active site residue [active] 585035008398 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 585035008399 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 585035008400 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 585035008401 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 585035008402 hypothetical protein; Provisional; Region: PRK10556 585035008403 hypothetical protein; Provisional; Region: PRK10132 585035008404 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 585035008405 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585035008406 DNA-binding site [nucleotide binding]; DNA binding site 585035008407 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585035008408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035008409 homodimer interface [polypeptide binding]; other site 585035008410 catalytic residue [active] 585035008411 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 585035008412 Uncharacterized conserved protein [Function unknown]; Region: COG2128 585035008413 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 585035008414 catalytic residues [active] 585035008415 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 585035008416 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 585035008417 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 585035008418 Class I ribonucleotide reductase; Region: RNR_I; cd01679 585035008419 active site 585035008420 dimer interface [polypeptide binding]; other site 585035008421 catalytic residues [active] 585035008422 effector binding site; other site 585035008423 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 585035008424 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 585035008425 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 585035008426 dimer interface [polypeptide binding]; other site 585035008427 putative radical transfer pathway; other site 585035008428 diiron center [ion binding]; other site 585035008429 tyrosyl radical; other site 585035008430 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 585035008431 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 585035008432 Walker A/P-loop; other site 585035008433 ATP binding site [chemical binding]; other site 585035008434 Q-loop/lid; other site 585035008435 ABC transporter signature motif; other site 585035008436 Walker B; other site 585035008437 D-loop; other site 585035008438 H-loop/switch region; other site 585035008439 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 585035008440 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 585035008441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035008442 dimer interface [polypeptide binding]; other site 585035008443 conserved gate region; other site 585035008444 putative PBP binding loops; other site 585035008445 ABC-ATPase subunit interface; other site 585035008446 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 585035008447 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 585035008448 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 585035008449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035008450 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 585035008451 putative L-valine exporter; Provisional; Region: PRK10408 585035008452 transcriptional repressor MprA; Provisional; Region: PRK10870 585035008453 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 585035008454 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 585035008455 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585035008456 HlyD family secretion protein; Region: HlyD_3; pfam13437 585035008457 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 585035008458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035008459 putative substrate translocation pore; other site 585035008460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035008461 RNA ligase; Region: RNA_ligase; pfam09414 585035008462 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 585035008463 Zn2+ binding site [ion binding]; other site 585035008464 Mg2+ binding site [ion binding]; other site 585035008465 AAA domain; Region: AAA_33; pfam13671 585035008466 S-ribosylhomocysteinase; Provisional; Region: PRK02260 585035008467 glutamate--cysteine ligase; Provisional; Region: PRK02107 585035008468 Predicted membrane protein [Function unknown]; Region: COG1238 585035008469 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 585035008470 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585035008471 motif II; other site 585035008472 carbon storage regulator; Provisional; Region: PRK01712 585035008473 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 585035008474 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 585035008475 motif 1; other site 585035008476 active site 585035008477 motif 2; other site 585035008478 motif 3; other site 585035008479 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 585035008480 DHHA1 domain; Region: DHHA1; pfam02272 585035008481 recombination regulator RecX; Reviewed; Region: recX; PRK00117 585035008482 recombinase A; Provisional; Region: recA; PRK09354 585035008483 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 585035008484 hexamer interface [polypeptide binding]; other site 585035008485 Walker A motif; other site 585035008486 ATP binding site [chemical binding]; other site 585035008487 Walker B motif; other site 585035008488 hypothetical protein; Validated; Region: PRK03661 585035008489 Transglycosylase SLT domain; Region: SLT_2; pfam13406 585035008490 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585035008491 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585035008492 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 585035008493 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 585035008494 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 585035008495 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 585035008496 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 585035008497 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 585035008498 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 585035008499 putative NAD(P) binding site [chemical binding]; other site 585035008500 active site 585035008501 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 585035008502 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 585035008503 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585035008504 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585035008505 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 585035008506 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 585035008507 putative active site [active] 585035008508 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 585035008509 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 585035008510 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 585035008511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035008512 Walker A motif; other site 585035008513 ATP binding site [chemical binding]; other site 585035008514 Walker B motif; other site 585035008515 arginine finger; other site 585035008516 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 585035008517 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 585035008518 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 585035008519 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 585035008520 iron binding site [ion binding]; other site 585035008521 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 585035008522 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585035008523 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585035008524 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 585035008525 Acylphosphatase; Region: Acylphosphatase; pfam00708 585035008526 HypF finger; Region: zf-HYPF; pfam07503 585035008527 HypF finger; Region: zf-HYPF; pfam07503 585035008528 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 585035008529 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 585035008530 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 585035008531 Transcriptional regulators [Transcription]; Region: PurR; COG1609 585035008532 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585035008533 DNA binding site [nucleotide binding] 585035008534 domain linker motif; other site 585035008535 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 585035008536 dimerization interface (closed form) [polypeptide binding]; other site 585035008537 ligand binding site [chemical binding]; other site 585035008538 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 585035008539 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585035008540 active site turn [active] 585035008541 phosphorylation site [posttranslational modification] 585035008542 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 585035008543 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 585035008544 beta-galactosidase; Region: BGL; TIGR03356 585035008545 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585035008546 non-specific DNA binding site [nucleotide binding]; other site 585035008547 salt bridge; other site 585035008548 sequence-specific DNA binding site [nucleotide binding]; other site 585035008549 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 585035008550 nickel binding site [ion binding]; other site 585035008551 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 585035008552 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 585035008553 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 585035008554 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585035008555 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 585035008556 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 585035008557 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 585035008558 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 585035008559 NADH dehydrogenase; Region: NADHdh; cl00469 585035008560 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 585035008561 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 585035008562 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 585035008563 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 585035008564 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 585035008565 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 585035008566 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 585035008567 hydrogenase assembly chaperone; Provisional; Region: PRK10409 585035008568 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 585035008569 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 585035008570 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 585035008571 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 585035008572 dimerization interface [polypeptide binding]; other site 585035008573 ATP binding site [chemical binding]; other site 585035008574 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 585035008575 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 585035008576 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 585035008577 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035008578 Walker A motif; other site 585035008579 ATP binding site [chemical binding]; other site 585035008580 Walker B motif; other site 585035008581 arginine finger; other site 585035008582 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585035008583 molybdenum-pterin binding domain; Region: Mop; TIGR00638 585035008584 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 585035008585 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 585035008586 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 585035008587 MutS domain I; Region: MutS_I; pfam01624 585035008588 MutS domain II; Region: MutS_II; pfam05188 585035008589 MutS domain III; Region: MutS_III; pfam05192 585035008590 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 585035008591 Walker A/P-loop; other site 585035008592 ATP binding site [chemical binding]; other site 585035008593 Q-loop/lid; other site 585035008594 ABC transporter signature motif; other site 585035008595 Walker B; other site 585035008596 D-loop; other site 585035008597 H-loop/switch region; other site 585035008598 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 585035008599 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 585035008600 active site 585035008601 metal binding site [ion binding]; metal-binding site 585035008602 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 585035008603 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 585035008604 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585035008605 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 585035008606 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 585035008607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 585035008608 putative aldolase; Validated; Region: PRK08130 585035008609 active site 585035008610 intersubunit interface [polypeptide binding]; other site 585035008611 Zn2+ binding site [ion binding]; other site 585035008612 hypothetical protein; Provisional; Region: PRK09989 585035008613 putative transporter; Provisional; Region: PRK09821 585035008614 GntP family permease; Region: GntP_permease; pfam02447 585035008615 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 585035008616 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 585035008617 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 585035008618 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 585035008619 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 585035008620 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 585035008621 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 585035008622 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585035008623 DNA binding residues [nucleotide binding] 585035008624 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 585035008625 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585035008626 Peptidase family M23; Region: Peptidase_M23; pfam01551 585035008627 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 585035008628 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035008629 S-adenosylmethionine binding site [chemical binding]; other site 585035008630 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 585035008631 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 585035008632 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 585035008633 Permutation of conserved domain; other site 585035008634 active site 585035008635 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 585035008636 homotrimer interaction site [polypeptide binding]; other site 585035008637 zinc binding site [ion binding]; other site 585035008638 CDP-binding sites; other site 585035008639 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 585035008640 substrate binding site; other site 585035008641 dimer interface; other site 585035008642 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 585035008643 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 585035008644 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 585035008645 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 585035008646 ligand-binding site [chemical binding]; other site 585035008647 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 585035008648 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 585035008649 CysD dimerization site [polypeptide binding]; other site 585035008650 G1 box; other site 585035008651 putative GEF interaction site [polypeptide binding]; other site 585035008652 GTP/Mg2+ binding site [chemical binding]; other site 585035008653 Switch I region; other site 585035008654 G2 box; other site 585035008655 G3 box; other site 585035008656 Switch II region; other site 585035008657 G4 box; other site 585035008658 G5 box; other site 585035008659 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 585035008660 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 585035008661 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 585035008662 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 585035008663 Active Sites [active] 585035008664 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 585035008665 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 585035008666 metal binding site [ion binding]; metal-binding site 585035008667 Hok/gef family; Region: HOK_GEF; pfam01848 585035008668 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 585035008669 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 585035008670 Active Sites [active] 585035008671 sulfite reductase subunit beta; Provisional; Region: PRK13504 585035008672 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 585035008673 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 585035008674 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 585035008675 Flavodoxin; Region: Flavodoxin_1; pfam00258 585035008676 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 585035008677 FAD binding pocket [chemical binding]; other site 585035008678 FAD binding motif [chemical binding]; other site 585035008679 catalytic residues [active] 585035008680 NAD binding pocket [chemical binding]; other site 585035008681 phosphate binding motif [ion binding]; other site 585035008682 beta-alpha-beta structure motif; other site 585035008683 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 585035008684 active site 585035008685 putative oxidoreductase FixC; Provisional; Region: PRK10157 585035008686 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 585035008687 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 585035008688 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 585035008689 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 585035008690 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 585035008691 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 585035008692 Ligand binding site [chemical binding]; other site 585035008693 Electron transfer flavoprotein domain; Region: ETF; pfam01012 585035008694 benzoate transport; Region: 2A0115; TIGR00895 585035008695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035008696 putative substrate translocation pore; other site 585035008697 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 585035008698 FAD binding domain; Region: FAD_binding_4; pfam01565 585035008699 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 585035008700 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 585035008701 NADP binding site [chemical binding]; other site 585035008702 homodimer interface [polypeptide binding]; other site 585035008703 active site 585035008704 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585035008705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035008706 putative substrate translocation pore; other site 585035008707 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 585035008708 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 585035008709 nucleotide binding site [chemical binding]; other site 585035008710 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 585035008711 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 585035008712 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 585035008713 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 585035008714 Repair protein; Region: Repair_PSII; pfam04536 585035008715 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 585035008716 Repair protein; Region: Repair_PSII; pfam04536 585035008717 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 585035008718 Repair protein; Region: Repair_PSII; pfam04536 585035008719 enolase; Provisional; Region: eno; PRK00077 585035008720 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 585035008721 dimer interface [polypeptide binding]; other site 585035008722 metal binding site [ion binding]; metal-binding site 585035008723 substrate binding pocket [chemical binding]; other site 585035008724 CTP synthetase; Validated; Region: pyrG; PRK05380 585035008725 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 585035008726 Catalytic site [active] 585035008727 active site 585035008728 UTP binding site [chemical binding]; other site 585035008729 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 585035008730 active site 585035008731 putative oxyanion hole; other site 585035008732 catalytic triad [active] 585035008733 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 585035008734 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 585035008735 homodimer interface [polypeptide binding]; other site 585035008736 metal binding site [ion binding]; metal-binding site 585035008737 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 585035008738 homodimer interface [polypeptide binding]; other site 585035008739 active site 585035008740 putative chemical substrate binding site [chemical binding]; other site 585035008741 metal binding site [ion binding]; metal-binding site 585035008742 toxin MazF; Provisional; Region: PRK09907 585035008743 antitoxin MazE; Provisional; Region: PRK09798 585035008744 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 585035008745 HD domain; Region: HD_4; pfam13328 585035008746 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 585035008747 synthetase active site [active] 585035008748 NTP binding site [chemical binding]; other site 585035008749 metal binding site [ion binding]; metal-binding site 585035008750 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 585035008751 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 585035008752 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 585035008753 TRAM domain; Region: TRAM; pfam01938 585035008754 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035008755 S-adenosylmethionine binding site [chemical binding]; other site 585035008756 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 585035008757 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 585035008758 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585035008759 dimerization interface [polypeptide binding]; other site 585035008760 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585035008761 dimer interface [polypeptide binding]; other site 585035008762 phosphorylation site [posttranslational modification] 585035008763 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035008764 ATP binding site [chemical binding]; other site 585035008765 Mg2+ binding site [ion binding]; other site 585035008766 G-X-G motif; other site 585035008767 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 585035008768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035008769 active site 585035008770 phosphorylation site [posttranslational modification] 585035008771 intermolecular recognition site; other site 585035008772 dimerization interface [polypeptide binding]; other site 585035008773 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 585035008774 putative binding surface; other site 585035008775 active site 585035008776 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 585035008777 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 585035008778 active site 585035008779 tetramer interface [polypeptide binding]; other site 585035008780 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 585035008781 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 585035008782 active site 585035008783 tetramer interface [polypeptide binding]; other site 585035008784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035008785 D-galactonate transporter; Region: 2A0114; TIGR00893 585035008786 putative substrate translocation pore; other site 585035008787 flavodoxin; Provisional; Region: PRK08105 585035008788 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 585035008789 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 585035008790 probable active site [active] 585035008791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 585035008792 SecY interacting protein Syd; Provisional; Region: PRK04968 585035008793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 585035008794 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 585035008795 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 585035008796 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 585035008797 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 585035008798 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 585035008799 serine transporter; Region: stp; TIGR00814 585035008800 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 585035008801 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 585035008802 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 585035008803 flap endonuclease-like protein; Provisional; Region: PRK09482 585035008804 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 585035008805 active site 585035008806 metal binding site 1 [ion binding]; metal-binding site 585035008807 putative 5' ssDNA interaction site; other site 585035008808 metal binding site 3; metal-binding site 585035008809 metal binding site 2 [ion binding]; metal-binding site 585035008810 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 585035008811 putative DNA binding site [nucleotide binding]; other site 585035008812 putative metal binding site [ion binding]; other site 585035008813 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 585035008814 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 585035008815 dimer interface [polypeptide binding]; other site 585035008816 active site 585035008817 metal binding site [ion binding]; metal-binding site 585035008818 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 585035008819 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 585035008820 intersubunit interface [polypeptide binding]; other site 585035008821 active site 585035008822 Zn2+ binding site [ion binding]; other site 585035008823 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 585035008824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035008825 putative substrate translocation pore; other site 585035008826 L-fucose isomerase; Provisional; Region: fucI; PRK10991 585035008827 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 585035008828 hexamer (dimer of trimers) interface [polypeptide binding]; other site 585035008829 trimer interface [polypeptide binding]; other site 585035008830 substrate binding site [chemical binding]; other site 585035008831 Mn binding site [ion binding]; other site 585035008832 L-fuculokinase; Provisional; Region: PRK10331 585035008833 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 585035008834 nucleotide binding site [chemical binding]; other site 585035008835 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 585035008836 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 585035008837 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585035008838 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585035008839 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 585035008840 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 585035008841 hypothetical protein; Provisional; Region: PRK10873 585035008842 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 585035008843 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035008844 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 585035008845 dimerization interface [polypeptide binding]; other site 585035008846 substrate binding pocket [chemical binding]; other site 585035008847 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 585035008848 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 585035008849 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 585035008850 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585035008851 catalytic residue [active] 585035008852 CsdA-binding activator; Provisional; Region: PRK15019 585035008853 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 585035008854 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 585035008855 putative ATP binding site [chemical binding]; other site 585035008856 putative substrate interface [chemical binding]; other site 585035008857 murein transglycosylase A; Provisional; Region: mltA; PRK11162 585035008858 MltA specific insert domain; Region: MltA; pfam03562 585035008859 3D domain; Region: 3D; pfam06725 585035008860 Protein of unknown function (DUF770); Region: DUF770; pfam05591 585035008861 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 585035008862 Protein of unknown function (DUF877); Region: DUF877; pfam05943 585035008863 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 585035008864 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 585035008865 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 585035008866 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 585035008867 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585035008868 ligand binding site [chemical binding]; other site 585035008869 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 585035008870 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 585035008871 Clp amino terminal domain; Region: Clp_N; pfam02861 585035008872 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035008873 Walker A motif; other site 585035008874 ATP binding site [chemical binding]; other site 585035008875 Walker B motif; other site 585035008876 arginine finger; other site 585035008877 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035008878 Walker A motif; other site 585035008879 ATP binding site [chemical binding]; other site 585035008880 Walker B motif; other site 585035008881 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 585035008882 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 585035008883 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 585035008884 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 585035008885 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 585035008886 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 585035008887 PGAP1-like protein; Region: PGAP1; pfam07819 585035008888 Evidence 4 : Homologs of previously reported genes of unknown function 585035008889 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 585035008890 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 585035008891 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 585035008892 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 585035008893 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 585035008894 PAAR motif; Region: PAAR_motif; pfam05488 585035008895 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 585035008896 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 585035008897 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 585035008898 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 585035008899 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 585035008900 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 585035008901 ImpA domain protein; Region: DUF3702; pfam12486 585035008902 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 585035008903 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 585035008904 putative ligand binding site [chemical binding]; other site 585035008905 putative NAD binding site [chemical binding]; other site 585035008906 catalytic site [active] 585035008907 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 585035008908 putative active site [active] 585035008909 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 585035008910 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585035008911 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035008912 homodimer interface [polypeptide binding]; other site 585035008913 catalytic residue [active] 585035008914 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 585035008915 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 585035008916 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585035008917 active site turn [active] 585035008918 phosphorylation site [posttranslational modification] 585035008919 CAT RNA binding domain; Region: CAT_RBD; pfam03123 585035008920 PRD domain; Region: PRD; pfam00874 585035008921 PRD domain; Region: PRD; pfam00874 585035008922 AMIN domain; Region: AMIN; pfam11741 585035008923 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 585035008924 active site 585035008925 metal binding site [ion binding]; metal-binding site 585035008926 N-acetylglutamate synthase; Validated; Region: PRK05279 585035008927 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 585035008928 putative feedback inhibition sensing region; other site 585035008929 putative nucleotide binding site [chemical binding]; other site 585035008930 putative substrate binding site [chemical binding]; other site 585035008931 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585035008932 Coenzyme A binding pocket [chemical binding]; other site 585035008933 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 585035008934 AAA domain; Region: AAA_30; pfam13604 585035008935 Family description; Region: UvrD_C_2; pfam13538 585035008936 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 585035008937 protease3; Provisional; Region: PRK15101 585035008938 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 585035008939 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 585035008940 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 585035008941 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 585035008942 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 585035008943 hypothetical protein; Provisional; Region: PRK10332 585035008944 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 585035008945 hypothetical protein; Provisional; Region: PRK11521 585035008946 hypothetical protein; Provisional; Region: PRK10557 585035008947 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 585035008948 hypothetical protein; Provisional; Region: PRK10506 585035008949 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 585035008950 thymidylate synthase; Reviewed; Region: thyA; PRK01827 585035008951 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 585035008952 dimerization interface [polypeptide binding]; other site 585035008953 active site 585035008954 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 585035008955 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 585035008956 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 585035008957 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 585035008958 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 585035008959 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 585035008960 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 585035008961 putative active site [active] 585035008962 Ap4A binding site [chemical binding]; other site 585035008963 nudix motif; other site 585035008964 putative metal binding site [ion binding]; other site 585035008965 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 585035008966 putative DNA-binding cleft [nucleotide binding]; other site 585035008967 putative DNA clevage site; other site 585035008968 molecular lever; other site 585035008969 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 585035008970 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 585035008971 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585035008972 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585035008973 active site 585035008974 catalytic tetrad [active] 585035008975 lysophospholipid transporter LplT; Provisional; Region: PRK11195 585035008976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035008977 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 585035008978 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 585035008979 putative acyl-acceptor binding pocket; other site 585035008980 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 585035008981 acyl-activating enzyme (AAE) consensus motif; other site 585035008982 putative AMP binding site [chemical binding]; other site 585035008983 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 585035008984 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585035008985 DNA binding site [nucleotide binding] 585035008986 domain linker motif; other site 585035008987 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 585035008988 dimerization interface (closed form) [polypeptide binding]; other site 585035008989 ligand binding site [chemical binding]; other site 585035008990 diaminopimelate decarboxylase; Provisional; Region: PRK11165 585035008991 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 585035008992 active site 585035008993 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585035008994 substrate binding site [chemical binding]; other site 585035008995 catalytic residues [active] 585035008996 dimer interface [polypeptide binding]; other site 585035008997 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 585035008998 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035008999 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585035009000 dimerization interface [polypeptide binding]; other site 585035009001 putative racemase; Provisional; Region: PRK10200 585035009002 aspartate racemase; Region: asp_race; TIGR00035 585035009003 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 585035009004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035009005 putative substrate translocation pore; other site 585035009006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035009007 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 585035009008 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 585035009009 NADP binding site [chemical binding]; other site 585035009010 homodimer interface [polypeptide binding]; other site 585035009011 active site 585035009012 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 585035009013 putative acyltransferase; Provisional; Region: PRK05790 585035009014 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 585035009015 dimer interface [polypeptide binding]; other site 585035009016 active site 585035009017 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 585035009018 serine transporter; Region: stp; TIGR00814 585035009019 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 585035009020 Peptidase family M23; Region: Peptidase_M23; pfam01551 585035009021 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 585035009022 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 585035009023 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 585035009024 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 585035009025 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 585035009026 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 585035009027 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 585035009028 catalytic loop [active] 585035009029 iron binding site [ion binding]; other site 585035009030 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 585035009031 GAF domain; Region: GAF; cl17456 585035009032 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 585035009033 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585035009034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035009035 Walker A motif; other site 585035009036 ATP binding site [chemical binding]; other site 585035009037 Walker B motif; other site 585035009038 arginine finger; other site 585035009039 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585035009040 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 585035009041 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 585035009042 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 585035009043 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 585035009044 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 585035009045 catalytic residue [active] 585035009046 peptidase; Reviewed; Region: PRK13004 585035009047 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 585035009048 putative metal binding site [ion binding]; other site 585035009049 putative dimer interface [polypeptide binding]; other site 585035009050 D-hydantoinase; Region: D-hydantoinase; TIGR02033 585035009051 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 585035009052 tetramer interface [polypeptide binding]; other site 585035009053 active site 585035009054 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 585035009055 carbamate kinase; Reviewed; Region: PRK12686 585035009056 putative substrate binding site [chemical binding]; other site 585035009057 homodimer interface [polypeptide binding]; other site 585035009058 nucleotide binding site [chemical binding]; other site 585035009059 nucleotide binding site [chemical binding]; other site 585035009060 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 585035009061 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 585035009062 XdhC Rossmann domain; Region: XdhC_C; pfam13478 585035009063 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 585035009064 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 585035009065 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 585035009066 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 585035009067 Ligand binding site; other site 585035009068 metal-binding site 585035009069 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 585035009070 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 585035009071 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585035009072 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 585035009073 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 585035009074 active site 585035009075 putative substrate binding pocket [chemical binding]; other site 585035009076 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 585035009077 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 585035009078 putative hypoxanthine oxidase; Provisional; Region: PRK09800 585035009079 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 585035009080 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 585035009081 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 585035009082 uracil-xanthine permease; Region: ncs2; TIGR00801 585035009083 guanine deaminase; Provisional; Region: PRK09228 585035009084 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 585035009085 active site 585035009086 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 585035009087 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 585035009088 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 585035009089 4Fe-4S binding domain; Region: Fer4; pfam00037 585035009090 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 585035009091 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585035009092 xanthine permease; Region: pbuX; TIGR03173 585035009093 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 585035009094 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 585035009095 active site 585035009096 metal binding site [ion binding]; metal-binding site 585035009097 nudix motif; other site 585035009098 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 585035009099 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 585035009100 dimer interface [polypeptide binding]; other site 585035009101 putative anticodon binding site; other site 585035009102 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 585035009103 motif 1; other site 585035009104 active site 585035009105 motif 2; other site 585035009106 motif 3; other site 585035009107 peptide chain release factor 2; Validated; Region: prfB; PRK00578 585035009108 This domain is found in peptide chain release factors; Region: PCRF; smart00937 585035009109 RF-1 domain; Region: RF-1; pfam00472 585035009110 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 585035009111 DHH family; Region: DHH; pfam01368 585035009112 DHHA1 domain; Region: DHHA1; pfam02272 585035009113 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 585035009114 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 585035009115 dimerization domain [polypeptide binding]; other site 585035009116 dimer interface [polypeptide binding]; other site 585035009117 catalytic residues [active] 585035009118 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 585035009119 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 585035009120 active site 585035009121 Int/Topo IB signature motif; other site 585035009122 flavodoxin FldB; Provisional; Region: PRK12359 585035009123 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 585035009124 hypothetical protein; Provisional; Region: PRK10878 585035009125 putative global regulator; Reviewed; Region: PRK09559 585035009126 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 585035009127 hemolysin; Provisional; Region: PRK15087 585035009128 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 585035009129 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 585035009130 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 585035009131 beta-galactosidase; Region: BGL; TIGR03356 585035009132 glycine dehydrogenase; Provisional; Region: PRK05367 585035009133 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 585035009134 tetramer interface [polypeptide binding]; other site 585035009135 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035009136 catalytic residue [active] 585035009137 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 585035009138 tetramer interface [polypeptide binding]; other site 585035009139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035009140 catalytic residue [active] 585035009141 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 585035009142 lipoyl attachment site [posttranslational modification]; other site 585035009143 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 585035009144 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 585035009145 oxidoreductase; Provisional; Region: PRK08013 585035009146 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 585035009147 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 585035009148 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 585035009149 proline aminopeptidase P II; Provisional; Region: PRK10879 585035009150 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 585035009151 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 585035009152 active site 585035009153 hypothetical protein; Reviewed; Region: PRK01736 585035009154 Z-ring-associated protein; Provisional; Region: PRK10972 585035009155 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 585035009156 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 585035009157 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 585035009158 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 585035009159 ligand binding site [chemical binding]; other site 585035009160 NAD binding site [chemical binding]; other site 585035009161 tetramer interface [polypeptide binding]; other site 585035009162 catalytic site [active] 585035009163 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 585035009164 L-serine binding site [chemical binding]; other site 585035009165 ACT domain interface; other site 585035009166 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 585035009167 tetramer (dimer of dimers) interface [polypeptide binding]; other site 585035009168 active site 585035009169 dimer interface [polypeptide binding]; other site 585035009170 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585035009171 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 585035009172 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035009173 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 585035009174 putative dimerization interface [polypeptide binding]; other site 585035009175 Evidence 7 : Gene remnant; Product type e : enzyme 585035009176 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035009177 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585035009178 Uncharacterized conserved protein [Function unknown]; Region: COG2968 585035009179 oxidative stress defense protein; Provisional; Region: PRK11087 585035009180 arginine exporter protein; Provisional; Region: PRK09304 585035009181 mechanosensitive channel MscS; Provisional; Region: PRK10334 585035009182 Mechanosensitive ion channel; Region: MS_channel; pfam00924 585035009183 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 585035009184 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 585035009185 active site 585035009186 intersubunit interface [polypeptide binding]; other site 585035009187 zinc binding site [ion binding]; other site 585035009188 Na+ binding site [ion binding]; other site 585035009189 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 585035009190 Phosphoglycerate kinase; Region: PGK; pfam00162 585035009191 substrate binding site [chemical binding]; other site 585035009192 hinge regions; other site 585035009193 ADP binding site [chemical binding]; other site 585035009194 catalytic site [active] 585035009195 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 585035009196 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 585035009197 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 585035009198 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 585035009199 trimer interface [polypeptide binding]; other site 585035009200 putative Zn binding site [ion binding]; other site 585035009201 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 585035009202 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 585035009203 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 585035009204 Walker A/P-loop; other site 585035009205 ATP binding site [chemical binding]; other site 585035009206 Q-loop/lid; other site 585035009207 ABC transporter signature motif; other site 585035009208 Walker B; other site 585035009209 D-loop; other site 585035009210 H-loop/switch region; other site 585035009211 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 585035009212 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 585035009213 Walker A/P-loop; other site 585035009214 ATP binding site [chemical binding]; other site 585035009215 Q-loop/lid; other site 585035009216 ABC transporter signature motif; other site 585035009217 Walker B; other site 585035009218 D-loop; other site 585035009219 H-loop/switch region; other site 585035009220 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 585035009221 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 585035009222 active site 585035009223 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 585035009224 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 585035009225 Evidence 7 : Gene remnant; Product type pe : enzyme 585035009226 Evidence 7 : Gene remnant; Product type pe : enzyme 585035009227 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 585035009228 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 585035009229 putative NAD(P) binding site [chemical binding]; other site 585035009230 catalytic Zn binding site [ion binding]; other site 585035009231 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 585035009232 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 585035009233 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 585035009234 active site 585035009235 P-loop; other site 585035009236 phosphorylation site [posttranslational modification] 585035009237 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585035009238 active site 585035009239 phosphorylation site [posttranslational modification] 585035009240 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 585035009241 SPFH domain / Band 7 family; Region: Band_7; pfam01145 585035009242 transketolase; Reviewed; Region: PRK12753 585035009243 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 585035009244 TPP-binding site [chemical binding]; other site 585035009245 dimer interface [polypeptide binding]; other site 585035009246 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 585035009247 PYR/PP interface [polypeptide binding]; other site 585035009248 dimer interface [polypeptide binding]; other site 585035009249 TPP binding site [chemical binding]; other site 585035009250 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 585035009251 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 585035009252 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 585035009253 agmatinase; Region: agmatinase; TIGR01230 585035009254 oligomer interface [polypeptide binding]; other site 585035009255 putative active site [active] 585035009256 Mn binding site [ion binding]; other site 585035009257 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 585035009258 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 585035009259 dimer interface [polypeptide binding]; other site 585035009260 active site 585035009261 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585035009262 catalytic residues [active] 585035009263 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 585035009264 Virulence promoting factor; Region: YqgB; pfam11036 585035009265 S-adenosylmethionine synthetase; Validated; Region: PRK05250 585035009266 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 585035009267 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 585035009268 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 585035009269 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 585035009270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035009271 putative substrate translocation pore; other site 585035009272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035009273 hypothetical protein; Provisional; Region: PRK04860 585035009274 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 585035009275 DNA-specific endonuclease I; Provisional; Region: PRK15137 585035009276 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 585035009277 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 585035009278 RNA methyltransferase, RsmE family; Region: TIGR00046 585035009279 glutathione synthetase; Provisional; Region: PRK05246 585035009280 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 585035009281 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 585035009282 hypothetical protein; Validated; Region: PRK00228 585035009283 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 585035009284 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 585035009285 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 585035009286 Walker A motif; other site 585035009287 ATP binding site [chemical binding]; other site 585035009288 Walker B motif; other site 585035009289 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 585035009290 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585035009291 catalytic residue [active] 585035009292 YGGT family; Region: YGGT; pfam02325 585035009293 YGGT family; Region: YGGT; pfam02325 585035009294 hypothetical protein; Validated; Region: PRK05090 585035009295 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 585035009296 active site 585035009297 dimerization interface [polypeptide binding]; other site 585035009298 HemN family oxidoreductase; Provisional; Region: PRK05660 585035009299 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585035009300 FeS/SAM binding site; other site 585035009301 HemN C-terminal domain; Region: HemN_C; pfam06969 585035009302 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 585035009303 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 585035009304 homodimer interface [polypeptide binding]; other site 585035009305 active site 585035009306 hypothetical protein; Provisional; Region: PRK10626 585035009307 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 585035009308 hypothetical protein; Provisional; Region: PRK11702 585035009309 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 585035009310 adenine DNA glycosylase; Provisional; Region: PRK10880 585035009311 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 585035009312 minor groove reading motif; other site 585035009313 helix-hairpin-helix signature motif; other site 585035009314 substrate binding pocket [chemical binding]; other site 585035009315 active site 585035009316 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 585035009317 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 585035009318 DNA binding and oxoG recognition site [nucleotide binding] 585035009319 oxidative damage protection protein; Provisional; Region: PRK05408 585035009320 murein transglycosylase C; Provisional; Region: mltC; PRK11671 585035009321 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 585035009322 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585035009323 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585035009324 catalytic residue [active] 585035009325 nucleoside transporter; Region: 2A0110; TIGR00889 585035009326 ornithine decarboxylase; Provisional; Region: PRK13578 585035009327 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 585035009328 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 585035009329 homodimer interface [polypeptide binding]; other site 585035009330 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035009331 catalytic residue [active] 585035009332 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 585035009333 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 585035009334 integrase; Provisional; Region: PRK09692 585035009335 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585035009336 active site 585035009337 Int/Topo IB signature motif; other site 585035009338 Part of AAA domain; Region: AAA_19; pfam13245 585035009339 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 585035009340 AAA domain; Region: AAA_12; pfam13087 585035009341 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 585035009342 putative active site [active] 585035009343 catalytic site [active] 585035009344 Evidence 7 : Gene remnant; Product type pe : enzyme 585035009345 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585035009346 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 585035009347 DNA binding residues [nucleotide binding] 585035009348 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 585035009349 Integrase core domain; Region: rve; pfam00665 585035009350 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 585035009351 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 585035009352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035009353 Walker A motif; other site 585035009354 ATP binding site [chemical binding]; other site 585035009355 Evidence 7 : Gene remnant; Product type pe : enzyme 585035009356 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 585035009357 PapG carbohydrate / receptor binding domain (CBD); PapG, the adhesin of the P-pili, is situated at the tip, mediating the attachment of uropathogenic Escherichia coli to the uroepithelium of the human kidney; PapG has a two-domain architecture: a...; Region: PapG_CBD; cd00239 585035009358 putative membrane interaction site; other site 585035009359 receptor/carbohydrate binding site; other site 585035009360 PapG chaperone-binding domain; Region: PapG_C; pfam03628 585035009361 Fimbrial protein; Region: Fimbrial; pfam00419 585035009362 Fimbrial protein; Region: Fimbrial; pfam00419 585035009363 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585035009364 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 585035009365 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585035009366 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585035009367 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 585035009368 PapC N-terminal domain; Region: PapC_N; pfam13954 585035009369 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585035009370 PapC C-terminal domain; Region: PapC_C; pfam13953 585035009371 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585035009372 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585035009373 Adhesin biosynthesis transcription regulatory protein; Region: PapB; pfam03333 585035009374 FaeA-like protein; Region: FaeA; pfam04703 585035009375 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 585035009376 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 585035009377 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 585035009378 Evidence 2b : Function of strongly homologous gene; Product type pe : enzyme 585035009379 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 585035009380 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 585035009381 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 585035009382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035009383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035009384 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 585035009385 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 585035009386 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 585035009387 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585035009388 dimer interface [polypeptide binding]; other site 585035009389 phosphorylation site [posttranslational modification] 585035009390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035009391 ATP binding site [chemical binding]; other site 585035009392 G-X-G motif; other site 585035009393 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 585035009394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035009395 active site 585035009396 phosphorylation site [posttranslational modification] 585035009397 intermolecular recognition site; other site 585035009398 dimerization interface [polypeptide binding]; other site 585035009399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 585035009400 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585035009401 PerC transcriptional activator; Region: PerC; pfam06069 585035009402 Evidence 1b : Function experimentally demonstrated in the studied species; Product type r : regulator 585035009403 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12057959; Product type r : regulator 585035009404 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 585035009405 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 585035009406 Active Sites [active] 585035009407 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 585035009408 AAA domain; Region: AAA_21; pfam13304 585035009409 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585035009410 Walker B; other site 585035009411 D-loop; other site 585035009412 H-loop/switch region; other site 585035009413 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 585035009414 putative active site [active] 585035009415 putative metal-binding site [ion binding]; other site 585035009416 putative transposase OrfB; Reviewed; Region: PHA02517 585035009417 HTH-like domain; Region: HTH_21; pfam13276 585035009418 Integrase core domain; Region: rve; pfam00665 585035009419 Integrase core domain; Region: rve_3; pfam13683 585035009420 Transposase; Region: HTH_Tnp_1; cl17663 585035009421 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme 585035009422 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme 585035009423 putative iron-regulated outer membrane virulence protein; Provisional; Region: PRK13484 585035009424 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585035009425 N-terminal plug; other site 585035009426 ligand-binding site [chemical binding]; other site 585035009427 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 585035009428 Predicted GTPase [General function prediction only]; Region: COG3596 585035009429 YfjP GTPase; Region: YfjP; cd11383 585035009430 G1 box; other site 585035009431 GTP/Mg2+ binding site [chemical binding]; other site 585035009432 Switch I region; other site 585035009433 G2 box; other site 585035009434 Switch II region; other site 585035009435 G3 box; other site 585035009436 G4 box; other site 585035009437 G5 box; other site 585035009438 HTH domain; Region: HTH_11; cl17392 585035009439 WYL domain; Region: WYL; pfam13280 585035009440 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 585035009441 Domain of unknown function (DUF932); Region: DUF932; pfam06067 585035009442 Antirestriction protein; Region: Antirestrict; pfam03230 585035009443 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 585035009444 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 585035009445 MPN+ (JAMM) motif; other site 585035009446 Zinc-binding site [ion binding]; other site 585035009447 Protein of unknown function (DUF987); Region: DUF987; pfam06174 585035009448 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 585035009449 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 585035009450 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 585035009451 Methyltransferase domain; Region: Methyltransf_27; pfam13708 585035009452 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 585035009453 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 585035009454 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585035009455 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme 585035009456 KpsF/GutQ family protein; Region: kpsF; TIGR00393 585035009457 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 585035009458 putative active site [active] 585035009459 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 585035009460 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 585035009461 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 585035009462 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 585035009463 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 585035009464 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 585035009465 Ligand binding site; other site 585035009466 oligomer interface; other site 585035009467 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 585035009468 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 585035009469 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 585035009470 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 585035009471 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 585035009472 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 585035009473 active site 585035009474 homodimer interface [polypeptide binding]; other site 585035009475 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 585035009476 ligand binding site; other site 585035009477 tetramer interface; other site 585035009478 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 585035009479 active site 585035009480 catalytic triad [active] 585035009481 oxyanion hole [active] 585035009482 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 585035009483 NeuB family; Region: NeuB; pfam03102 585035009484 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 585035009485 NeuB binding interface [polypeptide binding]; other site 585035009486 putative substrate binding site [chemical binding]; other site 585035009487 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 585035009488 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 585035009489 putative trimer interface [polypeptide binding]; other site 585035009490 putative CoA binding site [chemical binding]; other site 585035009491 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 585035009492 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 585035009493 Walker A/P-loop; other site 585035009494 ATP binding site [chemical binding]; other site 585035009495 Q-loop/lid; other site 585035009496 ABC transporter signature motif; other site 585035009497 Walker B; other site 585035009498 D-loop; other site 585035009499 H-loop/switch region; other site 585035009500 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 585035009501 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 585035009502 putative general secretion pathway protein YghD; Provisional; Region: PRK09731 585035009503 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 585035009504 GspL-like protein; Provisional; Region: PRK09662 585035009505 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 585035009506 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 585035009507 type II secretion system protein J; Region: gspJ; TIGR01711 585035009508 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 585035009509 type II secretion system protein I; Region: gspI; TIGR01707 585035009510 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 585035009511 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 585035009512 Type II transport protein GspH; Region: GspH; pfam12019 585035009513 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 585035009514 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 585035009515 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 585035009516 type II secretion system protein F; Region: GspF; TIGR02120 585035009517 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 585035009518 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 585035009519 type II secretion system protein E; Region: type_II_gspE; TIGR02533 585035009520 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 585035009521 Walker A motif; other site 585035009522 ATP binding site [chemical binding]; other site 585035009523 Walker B motif; other site 585035009524 type II secretion system protein D; Region: type_II_gspD; TIGR02517 585035009525 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 585035009526 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 585035009527 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 585035009528 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 585035009529 putative type II secretion protein GspC; Provisional; Region: PRK09681 585035009530 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 585035009531 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 585035009532 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 585035009533 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 585035009534 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 585035009535 Domain of unknown function (DUF4092); Region: DUF4092; pfam13322 585035009536 Peptidase M60-like family; Region: M60-like; pfam13402 585035009537 glycolate transporter; Provisional; Region: PRK09695 585035009538 L-lactate permease; Region: Lactate_perm; cl00701 585035009539 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 585035009540 active site 585035009541 hypothetical protein; Provisional; Region: PRK09732 585035009542 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 585035009543 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 585035009544 Cysteine-rich domain; Region: CCG; pfam02754 585035009545 Cysteine-rich domain; Region: CCG; pfam02754 585035009546 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 585035009547 FAD binding domain; Region: FAD_binding_4; pfam01565 585035009548 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 585035009549 FAD binding domain; Region: FAD_binding_4; pfam01565 585035009550 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 585035009551 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585035009552 DNA-binding site [nucleotide binding]; DNA binding site 585035009553 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585035009554 Evidence 7 : Gene remnant; Product type pe : enzyme 585035009555 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 585035009556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 585035009557 NAD(P) binding site [chemical binding]; other site 585035009558 active site 585035009559 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 585035009560 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 585035009561 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 585035009562 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585035009563 catalytic residue [active] 585035009564 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 585035009565 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 585035009566 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 585035009567 Predicted permeases [General function prediction only]; Region: COG0795 585035009568 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 585035009569 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 585035009570 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 585035009571 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 585035009572 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 585035009573 active site 585035009574 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 585035009575 TMP-binding site; other site 585035009576 ATP-binding site [chemical binding]; other site 585035009577 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 585035009578 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 585035009579 TMP-binding site; other site 585035009580 ATP-binding site [chemical binding]; other site 585035009581 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 585035009582 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 585035009583 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 585035009584 CHAP domain; Region: CHAP; pfam05257 585035009585 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 585035009586 putative S-transferase; Provisional; Region: PRK11752 585035009587 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 585035009588 C-terminal domain interface [polypeptide binding]; other site 585035009589 GSH binding site (G-site) [chemical binding]; other site 585035009590 dimer interface [polypeptide binding]; other site 585035009591 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 585035009592 dimer interface [polypeptide binding]; other site 585035009593 N-terminal domain interface [polypeptide binding]; other site 585035009594 active site 585035009595 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 585035009596 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 585035009597 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 585035009598 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 585035009599 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 585035009600 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 585035009601 putative substrate-binding site; other site 585035009602 nickel binding site [ion binding]; other site 585035009603 hydrogenase 2 large subunit; Provisional; Region: PRK10467 585035009604 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 585035009605 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 585035009606 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 585035009607 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 585035009608 4Fe-4S binding domain; Region: Fer4_6; pfam12837 585035009609 hydrogenase 2 small subunit; Provisional; Region: PRK10468 585035009610 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 585035009611 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 585035009612 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 585035009613 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 585035009614 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 585035009615 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585035009616 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585035009617 active site 585035009618 catalytic tetrad [active] 585035009619 hypothetical protein; Provisional; Region: PRK05208 585035009620 oxidoreductase; Provisional; Region: PRK07985 585035009621 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 585035009622 NAD binding site [chemical binding]; other site 585035009623 metal binding site [ion binding]; metal-binding site 585035009624 active site 585035009625 biopolymer transport protein ExbD; Provisional; Region: PRK11267 585035009626 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 585035009627 biopolymer transport protein ExbB; Provisional; Region: PRK10414 585035009628 cystathionine beta-lyase; Provisional; Region: PRK08114 585035009629 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 585035009630 homodimer interface [polypeptide binding]; other site 585035009631 substrate-cofactor binding pocket; other site 585035009632 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035009633 catalytic residue [active] 585035009634 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 585035009635 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 585035009636 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 585035009637 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 585035009638 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035009639 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035009640 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 585035009641 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 585035009642 dimer interface [polypeptide binding]; other site 585035009643 active site 585035009644 metal binding site [ion binding]; metal-binding site 585035009645 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 585035009646 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 585035009647 active site 585035009648 catalytic tetrad [active] 585035009649 putative outer membrane lipoprotein; Provisional; Region: PRK09973 585035009650 hypothetical protein; Provisional; Region: PRK01254 585035009651 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 585035009652 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 585035009653 Transcriptional regulators [Transcription]; Region: FadR; COG2186 585035009654 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585035009655 DNA-binding site [nucleotide binding]; DNA binding site 585035009656 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585035009657 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 585035009658 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 585035009659 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 585035009660 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 585035009661 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 585035009662 putative NAD(P) binding site [chemical binding]; other site 585035009663 catalytic Zn binding site [ion binding]; other site 585035009664 structural Zn binding site [ion binding]; other site 585035009665 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 585035009666 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 585035009667 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 585035009668 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 585035009669 DctM-like transporters; Region: DctM; pfam06808 585035009670 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 585035009671 FtsI repressor; Provisional; Region: PRK10883 585035009672 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 585035009673 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 585035009674 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 585035009675 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 585035009676 putative acyl-acceptor binding pocket; other site 585035009677 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 585035009678 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 585035009679 CAP-like domain; other site 585035009680 active site 585035009681 primary dimer interface [polypeptide binding]; other site 585035009682 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 585035009683 putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755 585035009684 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 585035009685 peptide binding site [polypeptide binding]; other site 585035009686 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 585035009687 TIGR00156 family protein; Region: TIGR00156 585035009688 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 585035009689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035009690 active site 585035009691 phosphorylation site [posttranslational modification] 585035009692 intermolecular recognition site; other site 585035009693 dimerization interface [polypeptide binding]; other site 585035009694 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585035009695 DNA binding site [nucleotide binding] 585035009696 sensor protein QseC; Provisional; Region: PRK10337 585035009697 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585035009698 dimer interface [polypeptide binding]; other site 585035009699 phosphorylation site [posttranslational modification] 585035009700 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035009701 ATP binding site [chemical binding]; other site 585035009702 Mg2+ binding site [ion binding]; other site 585035009703 G-X-G motif; other site 585035009704 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 585035009705 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 585035009706 Uncharacterized conserved protein [Function unknown]; Region: COG1359 585035009707 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 585035009708 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 585035009709 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cd04795 585035009710 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 585035009711 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 585035009712 siderophore binding site; other site 585035009713 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 585035009714 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585035009715 ABC-ATPase subunit interface; other site 585035009716 dimer interface [polypeptide binding]; other site 585035009717 putative PBP binding regions; other site 585035009718 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 585035009719 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585035009720 dimer interface [polypeptide binding]; other site 585035009721 putative PBP binding regions; other site 585035009722 ABC-ATPase subunit interface; other site 585035009723 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 585035009724 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 585035009725 Walker A/P-loop; other site 585035009726 ATP binding site [chemical binding]; other site 585035009727 Q-loop/lid; other site 585035009728 ABC transporter signature motif; other site 585035009729 Walker B; other site 585035009730 D-loop; other site 585035009731 H-loop/switch region; other site 585035009732 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 585035009733 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585035009734 N-terminal plug; other site 585035009735 ligand-binding site [chemical binding]; other site 585035009736 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 585035009737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035009738 ATP binding site [chemical binding]; other site 585035009739 Mg2+ binding site [ion binding]; other site 585035009740 G-X-G motif; other site 585035009741 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 585035009742 anchoring element; other site 585035009743 dimer interface [polypeptide binding]; other site 585035009744 ATP binding site [chemical binding]; other site 585035009745 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 585035009746 active site 585035009747 metal binding site [ion binding]; metal-binding site 585035009748 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 585035009749 esterase YqiA; Provisional; Region: PRK11071 585035009750 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 585035009751 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 585035009752 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 585035009753 active site 585035009754 metal binding site [ion binding]; metal-binding site 585035009755 hexamer interface [polypeptide binding]; other site 585035009756 putative dehydrogenase; Provisional; Region: PRK11039 585035009757 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 585035009758 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 585035009759 dimer interface [polypeptide binding]; other site 585035009760 ADP-ribose binding site [chemical binding]; other site 585035009761 active site 585035009762 nudix motif; other site 585035009763 metal binding site [ion binding]; metal-binding site 585035009764 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 585035009765 hypothetical protein; Provisional; Region: PRK11653 585035009766 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 585035009767 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 585035009768 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 585035009769 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 585035009770 catalytic residues [active] 585035009771 hinge region; other site 585035009772 alpha helical domain; other site 585035009773 putative disulfide oxidoreductase; Provisional; Region: PRK04307 585035009774 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 585035009775 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 585035009776 putative active site [active] 585035009777 metal binding site [ion binding]; metal-binding site 585035009778 zinc transporter ZupT; Provisional; Region: PRK04201 585035009779 ZIP Zinc transporter; Region: Zip; pfam02535 585035009780 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 585035009781 putative fimbrial protein; Provisional; Region: PRK09733 585035009782 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 585035009783 PapC N-terminal domain; Region: PapC_N; pfam13954 585035009784 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585035009785 PapC C-terminal domain; Region: PapC_C; pfam13953 585035009786 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 585035009787 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585035009788 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585035009789 Fimbrial protein; Region: Fimbrial; pfam00419 585035009790 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 585035009791 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 585035009792 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 585035009793 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 585035009794 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 585035009795 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 585035009796 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 585035009797 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 585035009798 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 585035009799 putative ribose interaction site [chemical binding]; other site 585035009800 putative ADP binding site [chemical binding]; other site 585035009801 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 585035009802 active site 585035009803 nucleotide binding site [chemical binding]; other site 585035009804 HIGH motif; other site 585035009805 KMSKS motif; other site 585035009806 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 585035009807 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 585035009808 metal binding triad; other site 585035009809 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 585035009810 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 585035009811 metal binding triad; other site 585035009812 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 585035009813 Uncharacterized conserved protein [Function unknown]; Region: COG3025 585035009814 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 585035009815 putative active site [active] 585035009816 putative metal binding residues [ion binding]; other site 585035009817 signature motif; other site 585035009818 putative triphosphate binding site [ion binding]; other site 585035009819 CHAD domain; Region: CHAD; pfam05235 585035009820 SH3 domain-containing protein; Provisional; Region: PRK10884 585035009821 Bacterial SH3 domain homologues; Region: SH3b; smart00287 585035009822 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 585035009823 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 585035009824 active site 585035009825 NTP binding site [chemical binding]; other site 585035009826 metal binding triad [ion binding]; metal-binding site 585035009827 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 585035009828 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 585035009829 Zn2+ binding site [ion binding]; other site 585035009830 Mg2+ binding site [ion binding]; other site 585035009831 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 585035009832 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 585035009833 homooctamer interface [polypeptide binding]; other site 585035009834 active site 585035009835 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 585035009836 transcriptional activator TtdR; Provisional; Region: PRK09801 585035009837 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035009838 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 585035009839 putative effector binding pocket; other site 585035009840 putative dimerization interface [polypeptide binding]; other site 585035009841 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 585035009842 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 585035009843 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 585035009844 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 585035009845 transmembrane helices; other site 585035009846 UGMP family protein; Validated; Region: PRK09604 585035009847 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 585035009848 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 585035009849 DNA primase; Validated; Region: dnaG; PRK05667 585035009850 CHC2 zinc finger; Region: zf-CHC2; pfam01807 585035009851 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 585035009852 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 585035009853 active site 585035009854 metal binding site [ion binding]; metal-binding site 585035009855 interdomain interaction site; other site 585035009856 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 585035009857 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 585035009858 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 585035009859 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 585035009860 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 585035009861 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 585035009862 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 585035009863 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 585035009864 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585035009865 DNA binding residues [nucleotide binding] 585035009866 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 585035009867 active site 585035009868 SUMO-1 interface [polypeptide binding]; other site 585035009869 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 585035009870 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 585035009871 FAD binding pocket [chemical binding]; other site 585035009872 FAD binding motif [chemical binding]; other site 585035009873 phosphate binding motif [ion binding]; other site 585035009874 NAD binding pocket [chemical binding]; other site 585035009875 Predicted transcriptional regulators [Transcription]; Region: COG1695 585035009876 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 585035009877 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585035009878 PAS fold; Region: PAS_3; pfam08447 585035009879 putative active site [active] 585035009880 heme pocket [chemical binding]; other site 585035009881 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 585035009882 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 585035009883 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 585035009884 dimer interface [polypeptide binding]; other site 585035009885 putative CheW interface [polypeptide binding]; other site 585035009886 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 585035009887 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585035009888 inhibitor-cofactor binding pocket; inhibition site 585035009889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035009890 catalytic residue [active] 585035009891 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 585035009892 dimer interface [polypeptide binding]; other site 585035009893 putative tRNA-binding site [nucleotide binding]; other site 585035009894 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 585035009895 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585035009896 DNA binding site [nucleotide binding] 585035009897 domain linker motif; other site 585035009898 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 585035009899 putative dimerization interface [polypeptide binding]; other site 585035009900 putative ligand binding site [chemical binding]; other site 585035009901 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 585035009902 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 585035009903 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 585035009904 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 585035009905 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 585035009906 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 585035009907 inner membrane transporter YjeM; Provisional; Region: PRK15238 585035009908 alpha-glucosidase; Provisional; Region: PRK10137 585035009909 Protein of unknown function, DUF608; Region: DUF608; pfam04685 585035009910 Trehalase; Region: Trehalase; cl17346 585035009911 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 585035009912 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 585035009913 active site 585035009914 FMN binding site [chemical binding]; other site 585035009915 2,4-decadienoyl-CoA binding site; other site 585035009916 catalytic residue [active] 585035009917 4Fe-4S cluster binding site [ion binding]; other site 585035009918 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 585035009919 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 585035009920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035009921 S-adenosylmethionine binding site [chemical binding]; other site 585035009922 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 585035009923 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 585035009924 putative active site [active] 585035009925 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 585035009926 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 585035009927 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 585035009928 serine/threonine transporter SstT; Provisional; Region: PRK13628 585035009929 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 585035009930 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 585035009931 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 585035009932 galactarate dehydratase; Region: galactar-dH20; TIGR03248 585035009933 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 585035009934 Glucuronate isomerase; Region: UxaC; pfam02614 585035009935 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 585035009936 D-galactonate transporter; Region: 2A0114; TIGR00893 585035009937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035009938 putative substrate translocation pore; other site 585035009939 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 585035009940 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585035009941 DNA-binding site [nucleotide binding]; DNA binding site 585035009942 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585035009943 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 585035009944 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 585035009945 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 585035009946 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 585035009947 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 585035009948 Predicted membrane protein [Function unknown]; Region: COG5393 585035009949 YqjK-like protein; Region: YqjK; pfam13997 585035009950 Predicted membrane protein [Function unknown]; Region: COG2259 585035009951 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 585035009952 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 585035009953 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 585035009954 putative dimer interface [polypeptide binding]; other site 585035009955 N-terminal domain interface [polypeptide binding]; other site 585035009956 putative substrate binding pocket (H-site) [chemical binding]; other site 585035009957 Predicted membrane protein [Function unknown]; Region: COG3152 585035009958 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035009959 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 585035009960 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585035009961 dimerization interface [polypeptide binding]; other site 585035009962 Pirin-related protein [General function prediction only]; Region: COG1741 585035009963 Pirin; Region: Pirin; pfam02678 585035009964 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 585035009965 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 585035009966 serine transporter; Region: stp; TIGR00814 585035009967 L-serine dehydratase TdcG; Provisional; Region: PRK15040 585035009968 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 585035009969 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 585035009970 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 585035009971 homotrimer interaction site [polypeptide binding]; other site 585035009972 putative active site [active] 585035009973 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 585035009974 Pyruvate formate lyase 1; Region: PFL1; cd01678 585035009975 coenzyme A binding site [chemical binding]; other site 585035009976 active site 585035009977 catalytic residues [active] 585035009978 glycine loop; other site 585035009979 propionate/acetate kinase; Provisional; Region: PRK12379 585035009980 Acetokinase family; Region: Acetate_kinase; cl17229 585035009981 threonine/serine transporter TdcC; Provisional; Region: PRK13629 585035009982 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 585035009983 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 585035009984 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 585035009985 tetramer interface [polypeptide binding]; other site 585035009986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035009987 catalytic residue [active] 585035009988 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 585035009989 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035009990 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 585035009991 putative substrate binding pocket [chemical binding]; other site 585035009992 putative dimerization interface [polypeptide binding]; other site 585035009993 glycerate kinase I; Provisional; Region: PRK10342 585035009994 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 585035009995 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 585035009996 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 585035009997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035009998 D-galactonate transporter; Region: 2A0114; TIGR00893 585035009999 putative substrate translocation pore; other site 585035010000 galactarate dehydratase; Region: galactar-dH20; TIGR03248 585035010001 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 585035010002 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 585035010003 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 585035010004 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585035010005 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585035010006 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 585035010007 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 585035010008 active site 585035010009 phosphorylation site [posttranslational modification] 585035010010 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 585035010011 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 585035010012 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 585035010013 active pocket/dimerization site; other site 585035010014 active site 585035010015 phosphorylation site [posttranslational modification] 585035010016 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 585035010017 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 585035010018 active site 585035010019 dimer interface [polypeptide binding]; other site 585035010020 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 585035010021 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 585035010022 dimer interface [polypeptide binding]; other site 585035010023 active site 585035010024 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 585035010025 putative active site [active] 585035010026 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453 585035010027 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 585035010028 active site 585035010029 intersubunit interface [polypeptide binding]; other site 585035010030 zinc binding site [ion binding]; other site 585035010031 Na+ binding site [ion binding]; other site 585035010032 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 585035010033 active site 585035010034 phosphorylation site [posttranslational modification] 585035010035 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 585035010036 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 585035010037 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 585035010038 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 585035010039 active site 585035010040 trimer interface [polypeptide binding]; other site 585035010041 allosteric site; other site 585035010042 active site lid [active] 585035010043 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 585035010044 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 585035010045 putative SAM binding site [chemical binding]; other site 585035010046 putative homodimer interface [polypeptide binding]; other site 585035010047 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 585035010048 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 585035010049 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 585035010050 putative ligand binding site [chemical binding]; other site 585035010051 TIGR00252 family protein; Region: TIGR00252 585035010052 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 585035010053 dimer interface [polypeptide binding]; other site 585035010054 active site 585035010055 outer membrane lipoprotein; Provisional; Region: PRK11023 585035010056 BON domain; Region: BON; pfam04972 585035010057 BON domain; Region: BON; pfam04972 585035010058 Predicted permease; Region: DUF318; pfam03773 585035010059 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 585035010060 NADH(P)-binding; Region: NAD_binding_10; pfam13460 585035010061 NAD binding site [chemical binding]; other site 585035010062 active site 585035010063 intracellular protease, PfpI family; Region: PfpI; TIGR01382 585035010064 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 585035010065 proposed catalytic triad [active] 585035010066 conserved cys residue [active] 585035010067 hypothetical protein; Provisional; Region: PRK03467 585035010068 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 585035010069 GIY-YIG motif/motif A; other site 585035010070 putative active site [active] 585035010071 putative metal binding site [ion binding]; other site 585035010072 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 585035010073 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585035010074 Coenzyme A binding pocket [chemical binding]; other site 585035010075 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 585035010076 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 585035010077 Peptidase family U32; Region: Peptidase_U32; pfam01136 585035010078 putative protease; Provisional; Region: PRK15447 585035010079 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 585035010080 hypothetical protein; Provisional; Region: PRK10508 585035010081 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 585035010082 tryptophan permease; Provisional; Region: PRK10483 585035010083 aromatic amino acid transport protein; Region: araaP; TIGR00837 585035010084 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 585035010085 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 585035010086 ATP binding site [chemical binding]; other site 585035010087 Mg++ binding site [ion binding]; other site 585035010088 motif III; other site 585035010089 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585035010090 nucleotide binding region [chemical binding]; other site 585035010091 ATP-binding site [chemical binding]; other site 585035010092 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 585035010093 putative RNA binding site [nucleotide binding]; other site 585035010094 lipoprotein NlpI; Provisional; Region: PRK11189 585035010095 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585035010096 binding surface 585035010097 TPR motif; other site 585035010098 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 585035010099 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 585035010100 RNase E interface [polypeptide binding]; other site 585035010101 trimer interface [polypeptide binding]; other site 585035010102 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 585035010103 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 585035010104 RNase E interface [polypeptide binding]; other site 585035010105 trimer interface [polypeptide binding]; other site 585035010106 active site 585035010107 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 585035010108 putative nucleic acid binding region [nucleotide binding]; other site 585035010109 G-X-X-G motif; other site 585035010110 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 585035010111 RNA binding site [nucleotide binding]; other site 585035010112 domain interface; other site 585035010113 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 585035010114 16S/18S rRNA binding site [nucleotide binding]; other site 585035010115 S13e-L30e interaction site [polypeptide binding]; other site 585035010116 25S rRNA binding site [nucleotide binding]; other site 585035010117 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 585035010118 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 585035010119 RNA binding site [nucleotide binding]; other site 585035010120 active site 585035010121 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 585035010122 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 585035010123 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 585035010124 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 585035010125 translation initiation factor IF-2; Region: IF-2; TIGR00487 585035010126 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 585035010127 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 585035010128 G1 box; other site 585035010129 putative GEF interaction site [polypeptide binding]; other site 585035010130 GTP/Mg2+ binding site [chemical binding]; other site 585035010131 Switch I region; other site 585035010132 G2 box; other site 585035010133 G3 box; other site 585035010134 Switch II region; other site 585035010135 G4 box; other site 585035010136 G5 box; other site 585035010137 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 585035010138 Translation-initiation factor 2; Region: IF-2; pfam11987 585035010139 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 585035010140 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 585035010141 NusA N-terminal domain; Region: NusA_N; pfam08529 585035010142 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 585035010143 RNA binding site [nucleotide binding]; other site 585035010144 homodimer interface [polypeptide binding]; other site 585035010145 NusA-like KH domain; Region: KH_5; pfam13184 585035010146 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 585035010147 G-X-X-G motif; other site 585035010148 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 585035010149 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 585035010150 ribosome maturation protein RimP; Reviewed; Region: PRK00092 585035010151 Sm and related proteins; Region: Sm_like; cl00259 585035010152 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 585035010153 putative oligomer interface [polypeptide binding]; other site 585035010154 putative RNA binding site [nucleotide binding]; other site 585035010155 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 585035010156 ANP binding site [chemical binding]; other site 585035010157 Substrate Binding Site II [chemical binding]; other site 585035010158 Substrate Binding Site I [chemical binding]; other site 585035010159 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 585035010160 Sulfatase; Region: Sulfatase; pfam00884 585035010161 Preprotein translocase SecG subunit; Region: SecG; pfam03840 585035010162 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 585035010163 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 585035010164 active site 585035010165 substrate binding site [chemical binding]; other site 585035010166 metal binding site [ion binding]; metal-binding site 585035010167 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 585035010168 dihydropteroate synthase; Region: DHPS; TIGR01496 585035010169 substrate binding pocket [chemical binding]; other site 585035010170 dimer interface [polypeptide binding]; other site 585035010171 inhibitor binding site; inhibition site 585035010172 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 585035010173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035010174 Walker A motif; other site 585035010175 ATP binding site [chemical binding]; other site 585035010176 Walker B motif; other site 585035010177 arginine finger; other site 585035010178 Peptidase family M41; Region: Peptidase_M41; pfam01434 585035010179 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 585035010180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035010181 S-adenosylmethionine binding site [chemical binding]; other site 585035010182 RNA-binding protein YhbY; Provisional; Region: PRK10343 585035010183 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 585035010184 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 585035010185 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 585035010186 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 585035010187 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 585035010188 GTPase CgtA; Reviewed; Region: obgE; PRK12298 585035010189 GTP1/OBG; Region: GTP1_OBG; pfam01018 585035010190 Obg GTPase; Region: Obg; cd01898 585035010191 G1 box; other site 585035010192 GTP/Mg2+ binding site [chemical binding]; other site 585035010193 Switch I region; other site 585035010194 G2 box; other site 585035010195 G3 box; other site 585035010196 Switch II region; other site 585035010197 G4 box; other site 585035010198 G5 box; other site 585035010199 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 585035010200 EamA-like transporter family; Region: EamA; pfam00892 585035010201 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 585035010202 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 585035010203 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 585035010204 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 585035010205 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 585035010206 substrate binding pocket [chemical binding]; other site 585035010207 chain length determination region; other site 585035010208 substrate-Mg2+ binding site; other site 585035010209 catalytic residues [active] 585035010210 aspartate-rich region 1; other site 585035010211 active site lid residues [active] 585035010212 aspartate-rich region 2; other site 585035010213 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 585035010214 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 585035010215 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 585035010216 hinge; other site 585035010217 active site 585035010218 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 585035010219 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 585035010220 anti sigma factor interaction site; other site 585035010221 regulatory phosphorylation site [posttranslational modification]; other site 585035010222 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 585035010223 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 585035010224 mce related protein; Region: MCE; pfam02470 585035010225 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 585035010226 conserved hypothetical integral membrane protein; Region: TIGR00056 585035010227 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 585035010228 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 585035010229 Walker A/P-loop; other site 585035010230 ATP binding site [chemical binding]; other site 585035010231 Q-loop/lid; other site 585035010232 ABC transporter signature motif; other site 585035010233 Walker B; other site 585035010234 D-loop; other site 585035010235 H-loop/switch region; other site 585035010236 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 585035010237 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 585035010238 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 585035010239 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 585035010240 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 585035010241 putative active site [active] 585035010242 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 585035010243 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 585035010244 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 585035010245 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 585035010246 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 585035010247 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 585035010248 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 585035010249 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 585035010250 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 585035010251 Walker A/P-loop; other site 585035010252 ATP binding site [chemical binding]; other site 585035010253 Q-loop/lid; other site 585035010254 ABC transporter signature motif; other site 585035010255 Walker B; other site 585035010256 D-loop; other site 585035010257 H-loop/switch region; other site 585035010258 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 585035010259 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 585035010260 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 585035010261 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 585035010262 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 585035010263 30S subunit binding site; other site 585035010264 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585035010265 active site 585035010266 phosphorylation site [posttranslational modification] 585035010267 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 585035010268 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585035010269 dimerization domain swap beta strand [polypeptide binding]; other site 585035010270 regulatory protein interface [polypeptide binding]; other site 585035010271 active site 585035010272 regulatory phosphorylation site [posttranslational modification]; other site 585035010273 hypothetical protein; Provisional; Region: PRK10345 585035010274 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 585035010275 Transglycosylase; Region: Transgly; cl17702 585035010276 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 585035010277 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 585035010278 conserved cys residue [active] 585035010279 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 585035010280 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585035010281 putative active site [active] 585035010282 heme pocket [chemical binding]; other site 585035010283 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585035010284 dimer interface [polypeptide binding]; other site 585035010285 phosphorylation site [posttranslational modification] 585035010286 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035010287 ATP binding site [chemical binding]; other site 585035010288 Mg2+ binding site [ion binding]; other site 585035010289 G-X-G motif; other site 585035010290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035010291 active site 585035010292 phosphorylation site [posttranslational modification] 585035010293 intermolecular recognition site; other site 585035010294 dimerization interface [polypeptide binding]; other site 585035010295 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 585035010296 putative binding surface; other site 585035010297 active site 585035010298 radical SAM protein, TIGR01212 family; Region: TIGR01212 585035010299 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585035010300 FeS/SAM binding site; other site 585035010301 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 585035010302 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 585035010303 active site 585035010304 dimer interface [polypeptide binding]; other site 585035010305 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 585035010306 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 585035010307 active site 585035010308 FMN binding site [chemical binding]; other site 585035010309 substrate binding site [chemical binding]; other site 585035010310 3Fe-4S cluster binding site [ion binding]; other site 585035010311 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 585035010312 domain interface; other site 585035010313 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 585035010314 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585035010315 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585035010316 Domain of unknown function (DUF386); Region: DUF386; cl01047 585035010317 N-acetylmannosamine kinase; Provisional; Region: PRK05082 585035010318 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585035010319 nucleotide binding site [chemical binding]; other site 585035010320 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 585035010321 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 585035010322 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 585035010323 putative active site cavity [active] 585035010324 putative sialic acid transporter; Provisional; Region: PRK03893 585035010325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035010326 putative substrate translocation pore; other site 585035010327 N-acetylneuraminate lyase; Region: nanA; TIGR00683 585035010328 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 585035010329 inhibitor site; inhibition site 585035010330 active site 585035010331 dimer interface [polypeptide binding]; other site 585035010332 catalytic residue [active] 585035010333 transcriptional regulator NanR; Provisional; Region: PRK03837 585035010334 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585035010335 DNA-binding site [nucleotide binding]; DNA binding site 585035010336 FCD domain; Region: FCD; pfam07729 585035010337 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 585035010338 stringent starvation protein A; Provisional; Region: sspA; PRK09481 585035010339 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 585035010340 C-terminal domain interface [polypeptide binding]; other site 585035010341 putative GSH binding site (G-site) [chemical binding]; other site 585035010342 dimer interface [polypeptide binding]; other site 585035010343 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 585035010344 dimer interface [polypeptide binding]; other site 585035010345 N-terminal domain interface [polypeptide binding]; other site 585035010346 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 585035010347 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 585035010348 23S rRNA interface [nucleotide binding]; other site 585035010349 L3 interface [polypeptide binding]; other site 585035010350 Predicted ATPase [General function prediction only]; Region: COG1485 585035010351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 585035010352 hypothetical protein; Provisional; Region: PRK11677 585035010353 serine endoprotease; Provisional; Region: PRK10139 585035010354 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 585035010355 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 585035010356 protein binding site [polypeptide binding]; other site 585035010357 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 585035010358 serine endoprotease; Provisional; Region: PRK10898 585035010359 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 585035010360 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 585035010361 malate dehydrogenase; Provisional; Region: PRK05086 585035010362 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 585035010363 NAD binding site [chemical binding]; other site 585035010364 dimerization interface [polypeptide binding]; other site 585035010365 Substrate binding site [chemical binding]; other site 585035010366 arginine repressor; Provisional; Region: PRK05066 585035010367 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 585035010368 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 585035010369 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585035010370 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 585035010371 RNAase interaction site [polypeptide binding]; other site 585035010372 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 585035010373 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 585035010374 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 585035010375 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585035010376 HlyD family secretion protein; Region: HlyD_3; pfam13437 585035010377 efflux system membrane protein; Provisional; Region: PRK11594 585035010378 transcriptional regulator; Provisional; Region: PRK10632 585035010379 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035010380 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 585035010381 putative effector binding pocket; other site 585035010382 dimerization interface [polypeptide binding]; other site 585035010383 protease TldD; Provisional; Region: tldD; PRK10735 585035010384 hypothetical protein; Provisional; Region: PRK10899 585035010385 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 585035010386 ribonuclease G; Provisional; Region: PRK11712 585035010387 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 585035010388 homodimer interface [polypeptide binding]; other site 585035010389 oligonucleotide binding site [chemical binding]; other site 585035010390 Maf-like protein; Region: Maf; pfam02545 585035010391 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 585035010392 active site 585035010393 dimer interface [polypeptide binding]; other site 585035010394 rod shape-determining protein MreD; Provisional; Region: PRK11060 585035010395 rod shape-determining protein MreC; Region: mreC; TIGR00219 585035010396 rod shape-determining protein MreC; Region: MreC; pfam04085 585035010397 rod shape-determining protein MreB; Provisional; Region: PRK13927 585035010398 MreB and similar proteins; Region: MreB_like; cd10225 585035010399 nucleotide binding site [chemical binding]; other site 585035010400 Mg binding site [ion binding]; other site 585035010401 putative protofilament interaction site [polypeptide binding]; other site 585035010402 RodZ interaction site [polypeptide binding]; other site 585035010403 regulatory protein CsrD; Provisional; Region: PRK11059 585035010404 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585035010405 metal binding site [ion binding]; metal-binding site 585035010406 active site 585035010407 I-site; other site 585035010408 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585035010409 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 585035010410 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 585035010411 NADP binding site [chemical binding]; other site 585035010412 dimer interface [polypeptide binding]; other site 585035010413 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 585035010414 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 585035010415 carboxyltransferase (CT) interaction site; other site 585035010416 biotinylation site [posttranslational modification]; other site 585035010417 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 585035010418 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 585035010419 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 585035010420 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 585035010421 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 585035010422 active site 585035010423 catalytic residues [active] 585035010424 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585035010425 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 585035010426 substrate binding site [chemical binding]; other site 585035010427 ATP binding site [chemical binding]; other site 585035010428 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585035010429 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585035010430 TM-ABC transporter signature motif; other site 585035010431 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 585035010432 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585035010433 Walker A/P-loop; other site 585035010434 ATP binding site [chemical binding]; other site 585035010435 Q-loop/lid; other site 585035010436 ABC transporter signature motif; other site 585035010437 Walker B; other site 585035010438 D-loop; other site 585035010439 H-loop/switch region; other site 585035010440 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585035010441 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 585035010442 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_12; cd06322 585035010443 putative ligand binding site [chemical binding]; other site 585035010444 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 585035010445 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 585035010446 intersubunit interface [polypeptide binding]; other site 585035010447 active site 585035010448 zinc binding site [ion binding]; other site 585035010449 Na+ binding site [ion binding]; other site 585035010450 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 585035010451 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 585035010452 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585035010453 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme 585035010454 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme 585035010455 hypothetical protein; Provisional; Region: PRK10633 585035010456 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 585035010457 Na binding site [ion binding]; other site 585035010458 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 585035010459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 585035010460 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 585035010461 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 585035010462 FMN binding site [chemical binding]; other site 585035010463 active site 585035010464 catalytic residues [active] 585035010465 substrate binding site [chemical binding]; other site 585035010466 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 585035010467 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 585035010468 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 585035010469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035010470 DNA methylase; Region: N6_N4_Mtase; pfam01555 585035010471 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 585035010472 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 585035010473 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585035010474 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 585035010475 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 585035010476 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585035010477 HlyD family secretion protein; Region: HlyD_3; pfam13437 585035010478 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 585035010479 Protein export membrane protein; Region: SecD_SecF; cl14618 585035010480 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 585035010481 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme 585035010482 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 585035010483 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585035010484 substrate binding pocket [chemical binding]; other site 585035010485 membrane-bound complex binding site; other site 585035010486 hinge residues; other site 585035010487 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 585035010488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035010489 conserved gate region; other site 585035010490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035010491 dimer interface [polypeptide binding]; other site 585035010492 conserved gate region; other site 585035010493 putative PBP binding loops; other site 585035010494 ABC-ATPase subunit interface; other site 585035010495 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 585035010496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035010497 dimer interface [polypeptide binding]; other site 585035010498 conserved gate region; other site 585035010499 putative PBP binding loops; other site 585035010500 ABC-ATPase subunit interface; other site 585035010501 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 585035010502 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 585035010503 Walker A/P-loop; other site 585035010504 ATP binding site [chemical binding]; other site 585035010505 Q-loop/lid; other site 585035010506 ABC transporter signature motif; other site 585035010507 Walker B; other site 585035010508 D-loop; other site 585035010509 H-loop/switch region; other site 585035010510 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 585035010511 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 585035010512 trimer interface [polypeptide binding]; other site 585035010513 putative metal binding site [ion binding]; other site 585035010514 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 585035010515 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 585035010516 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 585035010517 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 585035010518 shikimate binding site; other site 585035010519 NAD(P) binding site [chemical binding]; other site 585035010520 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 585035010521 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 585035010522 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 585035010523 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 585035010524 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 585035010525 hypothetical protein; Validated; Region: PRK03430 585035010526 hypothetical protein; Provisional; Region: PRK10736 585035010527 DNA protecting protein DprA; Region: dprA; TIGR00732 585035010528 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 585035010529 active site 585035010530 catalytic residues [active] 585035010531 metal binding site [ion binding]; metal-binding site 585035010532 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 585035010533 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 585035010534 putative active site [active] 585035010535 substrate binding site [chemical binding]; other site 585035010536 putative cosubstrate binding site; other site 585035010537 catalytic site [active] 585035010538 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 585035010539 substrate binding site [chemical binding]; other site 585035010540 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 585035010541 putative RNA binding site [nucleotide binding]; other site 585035010542 16S rRNA methyltransferase B; Provisional; Region: PRK10901 585035010543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035010544 S-adenosylmethionine binding site [chemical binding]; other site 585035010545 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 585035010546 TrkA-N domain; Region: TrkA_N; pfam02254 585035010547 TrkA-C domain; Region: TrkA_C; pfam02080 585035010548 TrkA-N domain; Region: TrkA_N; pfam02254 585035010549 TrkA-C domain; Region: TrkA_C; pfam02080 585035010550 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 585035010551 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 585035010552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 585035010553 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 585035010554 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 585035010555 DNA binding residues [nucleotide binding] 585035010556 dimer interface [polypeptide binding]; other site 585035010557 metal binding site [ion binding]; metal-binding site 585035010558 hypothetical protein; Provisional; Region: PRK10203 585035010559 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 585035010560 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 585035010561 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 585035010562 alphaNTD homodimer interface [polypeptide binding]; other site 585035010563 alphaNTD - beta interaction site [polypeptide binding]; other site 585035010564 alphaNTD - beta' interaction site [polypeptide binding]; other site 585035010565 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 585035010566 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 585035010567 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 585035010568 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585035010569 RNA binding surface [nucleotide binding]; other site 585035010570 30S ribosomal protein S11; Validated; Region: PRK05309 585035010571 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 585035010572 30S ribosomal protein S13; Region: bact_S13; TIGR03631 585035010573 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 585035010574 SecY translocase; Region: SecY; pfam00344 585035010575 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 585035010576 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 585035010577 23S rRNA binding site [nucleotide binding]; other site 585035010578 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 585035010579 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 585035010580 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 585035010581 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 585035010582 23S rRNA interface [nucleotide binding]; other site 585035010583 5S rRNA interface [nucleotide binding]; other site 585035010584 L27 interface [polypeptide binding]; other site 585035010585 L5 interface [polypeptide binding]; other site 585035010586 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 585035010587 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 585035010588 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 585035010589 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 585035010590 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 585035010591 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 585035010592 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 585035010593 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 585035010594 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 585035010595 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 585035010596 RNA binding site [nucleotide binding]; other site 585035010597 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 585035010598 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 585035010599 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 585035010600 23S rRNA interface [nucleotide binding]; other site 585035010601 putative translocon interaction site; other site 585035010602 signal recognition particle (SRP54) interaction site; other site 585035010603 L23 interface [polypeptide binding]; other site 585035010604 trigger factor interaction site; other site 585035010605 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 585035010606 23S rRNA interface [nucleotide binding]; other site 585035010607 5S rRNA interface [nucleotide binding]; other site 585035010608 putative antibiotic binding site [chemical binding]; other site 585035010609 L25 interface [polypeptide binding]; other site 585035010610 L27 interface [polypeptide binding]; other site 585035010611 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 585035010612 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 585035010613 G-X-X-G motif; other site 585035010614 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 585035010615 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 585035010616 protein-rRNA interface [nucleotide binding]; other site 585035010617 putative translocon binding site; other site 585035010618 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 585035010619 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 585035010620 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 585035010621 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 585035010622 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 585035010623 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 585035010624 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 585035010625 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 585035010626 protein secretion protein GspB; Provisional; Region: PRK09697 585035010627 AAA domain; Region: AAA_22; pfam13401 585035010628 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 585035010629 Type II secretory pathway, component PulC [Intracellular trafficking and secretion]; Region: PulC; COG3031 585035010630 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 585035010631 type II secretion system protein D; Region: type_II_gspD; TIGR02517 585035010632 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 585035010633 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 585035010634 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 585035010635 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 585035010636 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 585035010637 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 585035010638 Walker A motif; other site 585035010639 ATP binding site [chemical binding]; other site 585035010640 Walker B motif; other site 585035010641 type II secretion system protein F; Region: GspF; TIGR02120 585035010642 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 585035010643 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 585035010644 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 585035010645 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 585035010646 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 585035010647 Type II transport protein GspH; Region: GspH; pfam12019 585035010648 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 585035010649 type II secretion system protein I; Region: gspI; TIGR01707 585035010650 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 585035010651 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 585035010652 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 585035010653 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 585035010654 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 585035010655 Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297 585035010656 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 585035010657 GspL periplasmic domain; Region: GspL_C; pfam12693 585035010658 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 585035010659 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 585035010660 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 585035010661 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 585035010662 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 585035010663 heme binding site [chemical binding]; other site 585035010664 ferroxidase pore; other site 585035010665 ferroxidase diiron center [ion binding]; other site 585035010666 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 585035010667 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 585035010668 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 585035010669 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 585035010670 aromatic chitin/cellulose binding site residues [chemical binding]; other site 585035010671 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 585035010672 active site 585035010673 elongation factor Tu; Reviewed; Region: PRK00049 585035010674 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 585035010675 G1 box; other site 585035010676 GEF interaction site [polypeptide binding]; other site 585035010677 GTP/Mg2+ binding site [chemical binding]; other site 585035010678 Switch I region; other site 585035010679 G2 box; other site 585035010680 G3 box; other site 585035010681 Switch II region; other site 585035010682 G4 box; other site 585035010683 G5 box; other site 585035010684 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 585035010685 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 585035010686 Antibiotic Binding Site [chemical binding]; other site 585035010687 elongation factor G; Reviewed; Region: PRK00007 585035010688 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 585035010689 G1 box; other site 585035010690 putative GEF interaction site [polypeptide binding]; other site 585035010691 GTP/Mg2+ binding site [chemical binding]; other site 585035010692 Switch I region; other site 585035010693 G2 box; other site 585035010694 G3 box; other site 585035010695 Switch II region; other site 585035010696 G4 box; other site 585035010697 G5 box; other site 585035010698 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 585035010699 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 585035010700 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 585035010701 30S ribosomal protein S7; Validated; Region: PRK05302 585035010702 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 585035010703 S17 interaction site [polypeptide binding]; other site 585035010704 S8 interaction site; other site 585035010705 16S rRNA interaction site [nucleotide binding]; other site 585035010706 streptomycin interaction site [chemical binding]; other site 585035010707 23S rRNA interaction site [nucleotide binding]; other site 585035010708 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 585035010709 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 585035010710 sulfur relay protein TusC; Validated; Region: PRK00211 585035010711 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 585035010712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 585035010713 YheO-like PAS domain; Region: PAS_6; pfam08348 585035010714 HTH domain; Region: HTH_22; pfam13309 585035010715 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 585035010716 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 585035010717 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 585035010718 phi X174 lysis protein; Provisional; Region: PRK02793 585035010719 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 585035010720 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 585035010721 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 585035010722 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 585035010723 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 585035010724 TrkA-N domain; Region: TrkA_N; pfam02254 585035010725 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 585035010726 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 585035010727 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585035010728 Walker A/P-loop; other site 585035010729 ATP binding site [chemical binding]; other site 585035010730 Q-loop/lid; other site 585035010731 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 585035010732 ABC transporter signature motif; other site 585035010733 Walker B; other site 585035010734 D-loop; other site 585035010735 ABC transporter; Region: ABC_tran_2; pfam12848 585035010736 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 585035010737 putative hydrolase; Provisional; Region: PRK10985 585035010738 hypothetical protein; Provisional; Region: PRK04966 585035010739 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 585035010740 active site 585035010741 hypothetical protein; Provisional; Region: PRK10738 585035010742 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 585035010743 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 585035010744 ligand binding site [chemical binding]; other site 585035010745 flexible hinge region; other site 585035010746 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 585035010747 putative switch regulator; other site 585035010748 non-specific DNA interactions [nucleotide binding]; other site 585035010749 DNA binding site [nucleotide binding] 585035010750 sequence specific DNA binding site [nucleotide binding]; other site 585035010751 putative cAMP binding site [chemical binding]; other site 585035010752 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 585035010753 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 585035010754 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 585035010755 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 585035010756 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 585035010757 inhibitor-cofactor binding pocket; inhibition site 585035010758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035010759 catalytic residue [active] 585035010760 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 585035010761 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 585035010762 glutamine binding [chemical binding]; other site 585035010763 catalytic triad [active] 585035010764 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 585035010765 cell filamentation protein Fic; Provisional; Region: PRK10347 585035010766 hypothetical protein; Provisional; Region: PRK10204 585035010767 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 585035010768 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 585035010769 substrate binding site [chemical binding]; other site 585035010770 putative transporter; Provisional; Region: PRK03699 585035010771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035010772 putative substrate translocation pore; other site 585035010773 nitrite reductase subunit NirD; Provisional; Region: PRK14989 585035010774 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585035010775 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 585035010776 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 585035010777 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 585035010778 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 585035010779 nitrite transporter NirC; Provisional; Region: PRK11562 585035010780 siroheme synthase; Provisional; Region: cysG; PRK10637 585035010781 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 585035010782 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 585035010783 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 585035010784 active site 585035010785 SAM binding site [chemical binding]; other site 585035010786 homodimer interface [polypeptide binding]; other site 585035010787 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 585035010788 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 585035010789 Protein of unknown function; Region: YhfT; pfam10797 585035010790 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 585035010791 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 585035010792 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 585035010793 active site 585035010794 substrate binding pocket [chemical binding]; other site 585035010795 homodimer interaction site [polypeptide binding]; other site 585035010796 putative mutase; Provisional; Region: PRK12383 585035010797 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015 585035010798 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 585035010799 dimer interface [polypeptide binding]; other site 585035010800 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 585035010801 active site 585035010802 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585035010803 substrate binding site [chemical binding]; other site 585035010804 catalytic residue [active] 585035010805 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 585035010806 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 585035010807 active site 585035010808 HIGH motif; other site 585035010809 dimer interface [polypeptide binding]; other site 585035010810 KMSKS motif; other site 585035010811 phosphoglycolate phosphatase; Provisional; Region: PRK13222 585035010812 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585035010813 motif II; other site 585035010814 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 585035010815 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 585035010816 substrate binding site [chemical binding]; other site 585035010817 hexamer interface [polypeptide binding]; other site 585035010818 metal binding site [ion binding]; metal-binding site 585035010819 DNA adenine methylase; Provisional; Region: PRK10904 585035010820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 585035010821 cell division protein DamX; Validated; Region: PRK10905 585035010822 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 585035010823 active site 585035010824 dimer interface [polypeptide binding]; other site 585035010825 metal binding site [ion binding]; metal-binding site 585035010826 shikimate kinase; Reviewed; Region: aroK; PRK00131 585035010827 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 585035010828 ADP binding site [chemical binding]; other site 585035010829 magnesium binding site [ion binding]; other site 585035010830 putative shikimate binding site; other site 585035010831 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 585035010832 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 585035010833 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 585035010834 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 585035010835 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 585035010836 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 585035010837 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 585035010838 Transglycosylase; Region: Transgly; pfam00912 585035010839 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 585035010840 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 585035010841 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 585035010842 ADP-ribose binding site [chemical binding]; other site 585035010843 dimer interface [polypeptide binding]; other site 585035010844 active site 585035010845 nudix motif; other site 585035010846 metal binding site [ion binding]; metal-binding site 585035010847 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 585035010848 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 585035010849 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585035010850 motif II; other site 585035010851 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585035010852 RNA binding surface [nucleotide binding]; other site 585035010853 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 585035010854 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 585035010855 dimerization interface [polypeptide binding]; other site 585035010856 domain crossover interface; other site 585035010857 redox-dependent activation switch; other site 585035010858 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 585035010859 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 585035010860 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 585035010861 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 585035010862 active site 585035010863 substrate-binding site [chemical binding]; other site 585035010864 metal-binding site [ion binding] 585035010865 ATP binding site [chemical binding]; other site 585035010866 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 585035010867 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585035010868 dimerization interface [polypeptide binding]; other site 585035010869 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585035010870 dimer interface [polypeptide binding]; other site 585035010871 phosphorylation site [posttranslational modification] 585035010872 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035010873 ATP binding site [chemical binding]; other site 585035010874 G-X-G motif; other site 585035010875 osmolarity response regulator; Provisional; Region: ompR; PRK09468 585035010876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035010877 active site 585035010878 phosphorylation site [posttranslational modification] 585035010879 intermolecular recognition site; other site 585035010880 dimerization interface [polypeptide binding]; other site 585035010881 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585035010882 DNA binding site [nucleotide binding] 585035010883 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 585035010884 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 585035010885 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 585035010886 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 585035010887 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 585035010888 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 585035010889 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 585035010890 RNA binding site [nucleotide binding]; other site 585035010891 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 585035010892 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 585035010893 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 585035010894 G1 box; other site 585035010895 GTP/Mg2+ binding site [chemical binding]; other site 585035010896 Switch I region; other site 585035010897 G2 box; other site 585035010898 G3 box; other site 585035010899 Switch II region; other site 585035010900 G4 box; other site 585035010901 G5 box; other site 585035010902 Nucleoside recognition; Region: Gate; pfam07670 585035010903 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 585035010904 Nucleoside recognition; Region: Gate; pfam07670 585035010905 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 585035010906 putative transposase; Provisional; Region: PRK09857 585035010907 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 585035010908 carboxylesterase BioH; Provisional; Region: PRK10349 585035010909 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 585035010910 DNA utilization protein GntX; Provisional; Region: PRK11595 585035010911 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585035010912 active site 585035010913 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 585035010914 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 585035010915 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 585035010916 high-affinity gluconate transporter; Provisional; Region: PRK14984 585035010917 gluconate transporter; Region: gntP; TIGR00791 585035010918 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 585035010919 4-alpha-glucanotransferase; Region: malQ; TIGR00217 585035010920 maltodextrin phosphorylase; Provisional; Region: PRK14985 585035010921 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 585035010922 homodimer interface [polypeptide binding]; other site 585035010923 active site pocket [active] 585035010924 transcriptional regulator MalT; Provisional; Region: PRK04841 585035010925 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585035010926 DNA binding residues [nucleotide binding] 585035010927 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 585035010928 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 585035010929 putative active site [active] 585035010930 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 585035010931 hypothetical protein; Reviewed; Region: PRK09588 585035010932 Evidence 7 : Gene remnant; Product type r : regulator 585035010933 Evidence 7 : Gene remnant; Product type r : regulator 585035010934 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 585035010935 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585035010936 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585035010937 intramembrane serine protease GlpG; Provisional; Region: PRK10907 585035010938 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 585035010939 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 585035010940 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 585035010941 active site residue [active] 585035010942 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 585035010943 hypothetical protein; Provisional; Region: PRK09781; cl08057 585035010944 Fimbrial protein; Region: Fimbrial; cl01416 585035010945 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 585035010946 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585035010947 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585035010948 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585035010949 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585035010950 outer membrane usher protein; Provisional; Region: PRK15193 585035010951 PapC N-terminal domain; Region: PapC_N; pfam13954 585035010952 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585035010953 PapC C-terminal domain; Region: PapC_C; pfam13953 585035010954 fimbrial chaperone protein StiB; Provisional; Region: PRK15299 585035010955 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585035010956 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585035010957 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585035010958 glycogen phosphorylase; Provisional; Region: PRK14986 585035010959 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 585035010960 homodimer interface [polypeptide binding]; other site 585035010961 active site pocket [active] 585035010962 glycogen synthase; Provisional; Region: glgA; PRK00654 585035010963 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 585035010964 ADP-binding pocket [chemical binding]; other site 585035010965 homodimer interface [polypeptide binding]; other site 585035010966 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 585035010967 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 585035010968 ligand binding site; other site 585035010969 oligomer interface; other site 585035010970 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 585035010971 sulfate 1 binding site; other site 585035010972 glycogen debranching enzyme; Provisional; Region: PRK03705 585035010973 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 585035010974 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 585035010975 active site 585035010976 catalytic site [active] 585035010977 glycogen branching enzyme; Provisional; Region: PRK05402 585035010978 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 585035010979 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 585035010980 active site 585035010981 catalytic site [active] 585035010982 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 585035010983 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 585035010984 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 585035010985 putative antibiotic transporter; Provisional; Region: PRK10739 585035010986 low affinity gluconate transporter; Provisional; Region: PRK10472 585035010987 gluconate transporter; Region: gntP; TIGR00791 585035010988 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 585035010989 ATP-binding site [chemical binding]; other site 585035010990 Gluconate-6-phosphate binding site [chemical binding]; other site 585035010991 Shikimate kinase; Region: SKI; pfam01202 585035010992 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 585035010993 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585035010994 DNA binding site [nucleotide binding] 585035010995 domain linker motif; other site 585035010996 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 585035010997 putative ligand binding site [chemical binding]; other site 585035010998 putative dimerization interface [polypeptide binding]; other site 585035010999 Pirin-related protein [General function prediction only]; Region: COG1741 585035011000 Pirin; Region: Pirin; pfam02678 585035011001 putative oxidoreductase; Provisional; Region: PRK10206 585035011002 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 585035011003 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 585035011004 putative acetyltransferase YhhY; Provisional; Region: PRK10140 585035011005 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585035011006 Coenzyme A binding pocket [chemical binding]; other site 585035011007 Evidence 7 : Gene remnant 585035011008 Evidence 7 : Gene remnant 585035011009 YopJ Serine/Threonine acetyltransferase; Region: YopJ; cl07849 585035011010 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 585035011011 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 585035011012 hypothetical protein; Provisional; Region: PRK10350 585035011013 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 585035011014 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 585035011015 putative active site [active] 585035011016 catalytic site [active] 585035011017 putative metal binding site [ion binding]; other site 585035011018 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 585035011019 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 585035011020 Walker A/P-loop; other site 585035011021 ATP binding site [chemical binding]; other site 585035011022 Q-loop/lid; other site 585035011023 ABC transporter signature motif; other site 585035011024 Walker B; other site 585035011025 D-loop; other site 585035011026 H-loop/switch region; other site 585035011027 TOBE domain; Region: TOBE_2; pfam08402 585035011028 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 585035011029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035011030 dimer interface [polypeptide binding]; other site 585035011031 conserved gate region; other site 585035011032 putative PBP binding loops; other site 585035011033 ABC-ATPase subunit interface; other site 585035011034 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 585035011035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035011036 dimer interface [polypeptide binding]; other site 585035011037 conserved gate region; other site 585035011038 putative PBP binding loops; other site 585035011039 ABC-ATPase subunit interface; other site 585035011040 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 585035011041 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 585035011042 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 585035011043 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 585035011044 Walker A/P-loop; other site 585035011045 ATP binding site [chemical binding]; other site 585035011046 Q-loop/lid; other site 585035011047 ABC transporter signature motif; other site 585035011048 Walker B; other site 585035011049 D-loop; other site 585035011050 H-loop/switch region; other site 585035011051 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 585035011052 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 585035011053 Walker A/P-loop; other site 585035011054 ATP binding site [chemical binding]; other site 585035011055 Q-loop/lid; other site 585035011056 ABC transporter signature motif; other site 585035011057 Walker B; other site 585035011058 D-loop; other site 585035011059 H-loop/switch region; other site 585035011060 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 585035011061 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 585035011062 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 585035011063 TM-ABC transporter signature motif; other site 585035011064 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585035011065 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 585035011066 TM-ABC transporter signature motif; other site 585035011067 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 585035011068 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 585035011069 dimerization interface [polypeptide binding]; other site 585035011070 ligand binding site [chemical binding]; other site 585035011071 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 585035011072 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 585035011073 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 585035011074 dimerization interface [polypeptide binding]; other site 585035011075 ligand binding site [chemical binding]; other site 585035011076 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 585035011077 active pocket/dimerization site; other site 585035011078 active site 585035011079 phosphorylation site [posttranslational modification] 585035011080 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 585035011081 active site 585035011082 phosphorylation site [posttranslational modification] 585035011083 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 585035011084 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 585035011085 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 585035011086 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 585035011087 putative ligand binding site [chemical binding]; other site 585035011088 putative NAD binding site [chemical binding]; other site 585035011089 catalytic site [active] 585035011090 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 585035011091 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 585035011092 inhibitor site; inhibition site 585035011093 active site 585035011094 dimer interface [polypeptide binding]; other site 585035011095 catalytic residue [active] 585035011096 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 585035011097 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 585035011098 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585035011099 DNA binding residues [nucleotide binding] 585035011100 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 585035011101 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 585035011102 cell division protein FtsE; Provisional; Region: PRK10908 585035011103 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585035011104 Walker A/P-loop; other site 585035011105 ATP binding site [chemical binding]; other site 585035011106 Q-loop/lid; other site 585035011107 ABC transporter signature motif; other site 585035011108 Walker B; other site 585035011109 D-loop; other site 585035011110 H-loop/switch region; other site 585035011111 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 585035011112 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 585035011113 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 585035011114 P loop; other site 585035011115 GTP binding site [chemical binding]; other site 585035011116 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 585035011117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035011118 S-adenosylmethionine binding site [chemical binding]; other site 585035011119 hypothetical protein; Provisional; Region: PRK10910 585035011120 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 585035011121 Predicted membrane protein [Function unknown]; Region: COG3714 585035011122 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 585035011123 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 585035011124 metal-binding site [ion binding] 585035011125 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 585035011126 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 585035011127 CPxP motif; other site 585035011128 hypothetical protein; Provisional; Region: PRK11212 585035011129 hypothetical protein; Provisional; Region: PRK11615 585035011130 major facilitator superfamily transporter; Provisional; Region: PRK05122 585035011131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035011132 putative substrate translocation pore; other site 585035011133 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 585035011134 Domain of unknown function DUF20; Region: UPF0118; pfam01594 585035011135 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 585035011136 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 585035011137 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 585035011138 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 585035011139 substrate binding site [chemical binding]; other site 585035011140 nickel transporter permease NikB; Provisional; Region: PRK10352 585035011141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035011142 dimer interface [polypeptide binding]; other site 585035011143 conserved gate region; other site 585035011144 putative PBP binding loops; other site 585035011145 ABC-ATPase subunit interface; other site 585035011146 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 585035011147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035011148 dimer interface [polypeptide binding]; other site 585035011149 conserved gate region; other site 585035011150 putative PBP binding loops; other site 585035011151 ABC-ATPase subunit interface; other site 585035011152 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 585035011153 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585035011154 Walker A/P-loop; other site 585035011155 ATP binding site [chemical binding]; other site 585035011156 Q-loop/lid; other site 585035011157 ABC transporter signature motif; other site 585035011158 Walker B; other site 585035011159 D-loop; other site 585035011160 H-loop/switch region; other site 585035011161 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 585035011162 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 585035011163 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585035011164 Walker A/P-loop; other site 585035011165 ATP binding site [chemical binding]; other site 585035011166 Q-loop/lid; other site 585035011167 ABC transporter signature motif; other site 585035011168 Walker B; other site 585035011169 D-loop; other site 585035011170 H-loop/switch region; other site 585035011171 nickel responsive regulator; Provisional; Region: PRK02967 585035011172 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 585035011173 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 585035011174 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585035011175 DNA-binding site [nucleotide binding]; DNA binding site 585035011176 UTRA domain; Region: UTRA; pfam07702 585035011177 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585035011178 active site 585035011179 phosphorylation site [posttranslational modification] 585035011180 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 585035011181 active site 585035011182 P-loop; other site 585035011183 phosphorylation site [posttranslational modification] 585035011184 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 585035011185 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 585035011186 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 585035011187 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 585035011188 putative N- and C-terminal domain interface [polypeptide binding]; other site 585035011189 putative active site [active] 585035011190 putative MgATP binding site [chemical binding]; other site 585035011191 catalytic site [active] 585035011192 metal binding site [ion binding]; metal-binding site 585035011193 putative carbohydrate binding site [chemical binding]; other site 585035011194 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585035011195 dimerization domain swap beta strand [polypeptide binding]; other site 585035011196 regulatory protein interface [polypeptide binding]; other site 585035011197 active site 585035011198 regulatory phosphorylation site [posttranslational modification]; other site 585035011199 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 585035011200 intersubunit interface [polypeptide binding]; other site 585035011201 active site 585035011202 zinc binding site [ion binding]; other site 585035011203 Na+ binding site [ion binding]; other site 585035011204 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 585035011205 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 585035011206 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 585035011207 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 585035011208 Walker A/P-loop; other site 585035011209 ATP binding site [chemical binding]; other site 585035011210 Q-loop/lid; other site 585035011211 ABC transporter signature motif; other site 585035011212 Walker B; other site 585035011213 D-loop; other site 585035011214 H-loop/switch region; other site 585035011215 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 585035011216 Walker A/P-loop; other site 585035011217 ATP binding site [chemical binding]; other site 585035011218 Q-loop/lid; other site 585035011219 ABC transporter signature motif; other site 585035011220 Walker B; other site 585035011221 D-loop; other site 585035011222 H-loop/switch region; other site 585035011223 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 585035011224 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 585035011225 HlyD family secretion protein; Region: HlyD; pfam00529 585035011226 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585035011227 HlyD family secretion protein; Region: HlyD_3; pfam13437 585035011228 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 585035011229 Predicted flavoproteins [General function prediction only]; Region: COG2081 585035011230 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585035011231 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 585035011232 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 585035011233 universal stress protein UspB; Provisional; Region: PRK04960 585035011234 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585035011235 Ligand Binding Site [chemical binding]; other site 585035011236 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 585035011237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035011238 POT family; Region: PTR2; pfam00854 585035011239 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035011240 S-adenosylmethionine binding site [chemical binding]; other site 585035011241 oligopeptidase A; Provisional; Region: PRK10911 585035011242 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 585035011243 active site 585035011244 Zn binding site [ion binding]; other site 585035011245 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 585035011246 glutathione reductase; Validated; Region: PRK06116 585035011247 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585035011248 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585035011249 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 585035011250 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 585035011251 ArsC family; Region: ArsC; pfam03960 585035011252 catalytic residues [active] 585035011253 Evidence 7 : Gene remnant 585035011254 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 585035011255 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 585035011256 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585035011257 DNA binding residues [nucleotide binding] 585035011258 dimerization interface [polypeptide binding]; other site 585035011259 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 585035011260 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 585035011261 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 585035011262 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 585035011263 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585035011264 N-terminal plug; other site 585035011265 ligand-binding site [chemical binding]; other site 585035011266 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 585035011267 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 585035011268 putative hemin binding site; other site 585035011269 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 585035011270 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585035011271 FeS/SAM binding site; other site 585035011272 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721 585035011273 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 585035011274 NADH(P)-binding; Region: NAD_binding_10; pfam13460 585035011275 NAD(P) binding site [chemical binding]; other site 585035011276 putative active site [active] 585035011277 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 585035011278 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585035011279 ABC-ATPase subunit interface; other site 585035011280 dimer interface [polypeptide binding]; other site 585035011281 putative PBP binding regions; other site 585035011282 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 585035011283 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 585035011284 Walker A/P-loop; other site 585035011285 ATP binding site [chemical binding]; other site 585035011286 Q-loop/lid; other site 585035011287 ABC transporter signature motif; other site 585035011288 Walker B; other site 585035011289 D-loop; other site 585035011290 H-loop/switch region; other site 585035011291 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 585035011292 MgtC family; Region: MgtC; pfam02308 585035011293 acid-resistance protein; Provisional; Region: hdeB; PRK11566 585035011294 acid-resistance protein; Provisional; Region: PRK10208 585035011295 acid-resistance membrane protein; Provisional; Region: PRK10209 585035011296 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 585035011297 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 585035011298 pyruvate kinase; Provisional; Region: PRK05826 585035011299 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 585035011300 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585035011301 HlyD family secretion protein; Region: HlyD_3; pfam13437 585035011302 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 585035011303 Protein export membrane protein; Region: SecD_SecF; cl14618 585035011304 transcriptional regulator YdeO; Provisional; Region: PRK09940 585035011305 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035011306 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 585035011307 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035011308 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 585035011309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035011310 catalytic residue [active] 585035011311 Haem-binding domain; Region: Haem_bd; pfam14376 585035011312 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 585035011313 trehalase; Provisional; Region: treF; PRK13270 585035011314 Trehalase; Region: Trehalase; pfam01204 585035011315 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 585035011316 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585035011317 DNA binding residues [nucleotide binding] 585035011318 dimerization interface [polypeptide binding]; other site 585035011319 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585035011320 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035011321 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 585035011322 putative effector binding pocket; other site 585035011323 putative dimerization interface [polypeptide binding]; other site 585035011324 inner membrane protein YhjD; Region: TIGR00766 585035011325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035011326 metabolite-proton symporter; Region: 2A0106; TIGR00883 585035011327 putative substrate translocation pore; other site 585035011328 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 585035011329 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 585035011330 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585035011331 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585035011332 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 585035011333 substrate binding site [chemical binding]; other site 585035011334 ATP binding site [chemical binding]; other site 585035011335 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 585035011336 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 585035011337 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 585035011338 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 585035011339 putative diguanylate cyclase; Provisional; Region: PRK13561 585035011340 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 585035011341 metal binding site [ion binding]; metal-binding site 585035011342 active site 585035011343 I-site; other site 585035011344 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585035011345 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 585035011346 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585035011347 binding surface 585035011348 TPR motif; other site 585035011349 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585035011350 binding surface 585035011351 TPR motif; other site 585035011352 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 585035011353 TPR motif; other site 585035011354 binding surface 585035011355 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 585035011356 endo-1,4-D-glucanase; Provisional; Region: PRK11097 585035011357 cellulose synthase regulator protein; Provisional; Region: PRK11114 585035011358 Evidence 7 : Gene remnant; Product type e : enzyme 585035011359 Evidence 7 : Gene remnant; Product type e : enzyme 585035011360 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12382054 585035011361 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 585035011362 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 585035011363 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 585035011364 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 585035011365 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 585035011366 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 585035011367 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 585035011368 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 585035011369 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 585035011370 serine transporter; Region: stp; TIGR00814 585035011371 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 585035011372 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585035011373 Walker A/P-loop; other site 585035011374 ATP binding site [chemical binding]; other site 585035011375 Q-loop/lid; other site 585035011376 ABC transporter signature motif; other site 585035011377 Walker B; other site 585035011378 D-loop; other site 585035011379 H-loop/switch region; other site 585035011380 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 585035011381 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 585035011382 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585035011383 Walker A/P-loop; other site 585035011384 ATP binding site [chemical binding]; other site 585035011385 Q-loop/lid; other site 585035011386 ABC transporter signature motif; other site 585035011387 Walker B; other site 585035011388 D-loop; other site 585035011389 H-loop/switch region; other site 585035011390 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 585035011391 dipeptide transporter; Provisional; Region: PRK10913 585035011392 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 585035011393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035011394 dimer interface [polypeptide binding]; other site 585035011395 conserved gate region; other site 585035011396 putative PBP binding loops; other site 585035011397 ABC-ATPase subunit interface; other site 585035011398 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 585035011399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035011400 dimer interface [polypeptide binding]; other site 585035011401 conserved gate region; other site 585035011402 putative PBP binding loops; other site 585035011403 ABC-ATPase subunit interface; other site 585035011404 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 585035011405 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 585035011406 peptide binding site [polypeptide binding]; other site 585035011407 phosphoethanolamine transferase; Provisional; Region: PRK11560 585035011408 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 585035011409 Sulfatase; Region: Sulfatase; pfam00884 585035011410 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 585035011411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035011412 putative substrate translocation pore; other site 585035011413 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 585035011414 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 585035011415 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 585035011416 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585035011417 Coenzyme A binding pocket [chemical binding]; other site 585035011418 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 585035011419 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 585035011420 molybdopterin cofactor binding site [chemical binding]; other site 585035011421 substrate binding site [chemical binding]; other site 585035011422 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 585035011423 molybdopterin cofactor binding site; other site 585035011424 putative outer membrane lipoprotein; Provisional; Region: PRK10510 585035011425 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 585035011426 ligand binding site [chemical binding]; other site 585035011427 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 585035011428 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 585035011429 dimerization interface [polypeptide binding]; other site 585035011430 ligand binding site [chemical binding]; other site 585035011431 NADP binding site [chemical binding]; other site 585035011432 catalytic site [active] 585035011433 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 585035011434 Predicted transcriptional regulator [Transcription]; Region: COG2944 585035011435 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585035011436 non-specific DNA binding site [nucleotide binding]; other site 585035011437 salt bridge; other site 585035011438 sequence-specific DNA binding site [nucleotide binding]; other site 585035011439 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585035011440 DNA-binding site [nucleotide binding]; DNA binding site 585035011441 RNA-binding motif; other site 585035011442 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 585035011443 DALR anticodon binding domain; Region: DALR_1; pfam05746 585035011444 anticodon binding site; other site 585035011445 tRNA binding surface [nucleotide binding]; other site 585035011446 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 585035011447 dimer interface [polypeptide binding]; other site 585035011448 motif 1; other site 585035011449 active site 585035011450 motif 2; other site 585035011451 motif 3; other site 585035011452 YsaB-like lipoprotein; Region: YsaB; pfam13983 585035011453 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 585035011454 Acyltransferase family; Region: Acyl_transf_3; pfam01757 585035011455 hypothetical protein; Provisional; Region: PRK11383 585035011456 yiaA/B two helix domain; Region: YiaAB; pfam05360 585035011457 yiaA/B two helix domain; Region: YiaAB; pfam05360 585035011458 hypothetical protein; Provisional; Region: PRK11403 585035011459 yiaA/B two helix domain; Region: YiaAB; pfam05360 585035011460 xylulokinase; Provisional; Region: PRK15027 585035011461 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 585035011462 N- and C-terminal domain interface [polypeptide binding]; other site 585035011463 active site 585035011464 MgATP binding site [chemical binding]; other site 585035011465 catalytic site [active] 585035011466 metal binding site [ion binding]; metal-binding site 585035011467 xylulose binding site [chemical binding]; other site 585035011468 homodimer interface [polypeptide binding]; other site 585035011469 xylose isomerase; Provisional; Region: PRK05474 585035011470 xylose isomerase; Region: xylose_isom_A; TIGR02630 585035011471 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 585035011472 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 585035011473 putative ligand binding site [chemical binding]; other site 585035011474 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 585035011475 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585035011476 Walker A/P-loop; other site 585035011477 ATP binding site [chemical binding]; other site 585035011478 Q-loop/lid; other site 585035011479 ABC transporter signature motif; other site 585035011480 Walker B; other site 585035011481 D-loop; other site 585035011482 H-loop/switch region; other site 585035011483 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585035011484 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585035011485 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585035011486 TM-ABC transporter signature motif; other site 585035011487 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 585035011488 putative dimerization interface [polypeptide binding]; other site 585035011489 Transcriptional regulators [Transcription]; Region: PurR; COG1609 585035011490 putative ligand binding site [chemical binding]; other site 585035011491 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035011492 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585035011493 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035011494 hypothetical protein; Provisional; Region: PRK10356 585035011495 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 585035011496 alpha-amylase; Reviewed; Region: malS; PRK09505 585035011497 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 585035011498 active site 585035011499 catalytic site [active] 585035011500 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 585035011501 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585035011502 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035011503 homodimer interface [polypeptide binding]; other site 585035011504 catalytic residue [active] 585035011505 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 585035011506 Transcriptional regulator [Transcription]; Region: IclR; COG1414 585035011507 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 585035011508 Bacterial transcriptional regulator; Region: IclR; pfam01614 585035011509 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 585035011510 Domain of unknown function (DUF386); Region: DUF386; pfam04074 585035011511 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 585035011512 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 585035011513 DctM-like transporters; Region: DctM; pfam06808 585035011514 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 585035011515 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 585035011516 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 585035011517 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 585035011518 putative N- and C-terminal domain interface [polypeptide binding]; other site 585035011519 putative active site [active] 585035011520 MgATP binding site [chemical binding]; other site 585035011521 catalytic site [active] 585035011522 metal binding site [ion binding]; metal-binding site 585035011523 putative xylulose binding site [chemical binding]; other site 585035011524 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 585035011525 active site 585035011526 dimer interface [polypeptide binding]; other site 585035011527 magnesium binding site [ion binding]; other site 585035011528 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 585035011529 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 585035011530 AP (apurinic/apyrimidinic) site pocket; other site 585035011531 DNA interaction; other site 585035011532 Metal-binding active site; metal-binding site 585035011533 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 585035011534 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 585035011535 intersubunit interface [polypeptide binding]; other site 585035011536 active site 585035011537 Zn2+ binding site [ion binding]; other site 585035011538 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 585035011539 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 585035011540 NAD(P) binding site [chemical binding]; other site 585035011541 catalytic residues [active] 585035011542 Fic family protein [Function unknown]; Region: COG3177 585035011543 Fic/DOC family; Region: Fic; pfam02661 585035011544 putative alcohol dehydrogenase; Provisional; Region: PRK09860 585035011545 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 585035011546 dimer interface [polypeptide binding]; other site 585035011547 active site 585035011548 metal binding site [ion binding]; metal-binding site 585035011549 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 585035011550 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 585035011551 G1 box; other site 585035011552 putative GEF interaction site [polypeptide binding]; other site 585035011553 GTP/Mg2+ binding site [chemical binding]; other site 585035011554 Switch I region; other site 585035011555 G2 box; other site 585035011556 G3 box; other site 585035011557 Switch II region; other site 585035011558 G4 box; other site 585035011559 G5 box; other site 585035011560 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 585035011561 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 585035011562 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 585035011563 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 585035011564 selenocysteine synthase; Provisional; Region: PRK04311 585035011565 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 585035011566 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 585035011567 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585035011568 catalytic residue [active] 585035011569 putative glutathione S-transferase; Provisional; Region: PRK10357 585035011570 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 585035011571 putative C-terminal domain interface [polypeptide binding]; other site 585035011572 putative GSH binding site (G-site) [chemical binding]; other site 585035011573 putative dimer interface [polypeptide binding]; other site 585035011574 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 585035011575 dimer interface [polypeptide binding]; other site 585035011576 N-terminal domain interface [polypeptide binding]; other site 585035011577 putative substrate binding pocket (H-site) [chemical binding]; other site 585035011578 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 585035011579 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585035011580 HlyD family secretion protein; Region: HlyD_3; pfam13437 585035011581 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 585035011582 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 585035011583 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 585035011584 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 585035011585 active site 585035011586 P-loop; other site 585035011587 phosphorylation site [posttranslational modification] 585035011588 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585035011589 active site 585035011590 phosphorylation site [posttranslational modification] 585035011591 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 585035011592 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 585035011593 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 585035011594 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 585035011595 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 585035011596 hypothetical protein; Provisional; Region: PRK11020 585035011597 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 585035011598 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 585035011599 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 585035011600 trimer interface [polypeptide binding]; other site 585035011601 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 585035011602 trimer interface [polypeptide binding]; other site 585035011603 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 585035011604 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 585035011605 Haemagglutinin; Region: HIM; pfam05662 585035011606 Haemagglutinin; Region: HIM; pfam05662 585035011607 YadA-like C-terminal region; Region: YadA; pfam03895 585035011608 L-lactate permease; Provisional; Region: PRK10420 585035011609 glycolate transporter; Provisional; Region: PRK09695 585035011610 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 585035011611 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585035011612 DNA-binding site [nucleotide binding]; DNA binding site 585035011613 FCD domain; Region: FCD; pfam07729 585035011614 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 585035011615 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 585035011616 active site 585035011617 substrate binding site [chemical binding]; other site 585035011618 FMN binding site [chemical binding]; other site 585035011619 putative catalytic residues [active] 585035011620 putative rRNA methylase; Provisional; Region: PRK10358 585035011621 serine acetyltransferase; Provisional; Region: cysE; PRK11132 585035011622 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 585035011623 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 585035011624 trimer interface [polypeptide binding]; other site 585035011625 active site 585035011626 substrate binding site [chemical binding]; other site 585035011627 CoA binding site [chemical binding]; other site 585035011628 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 585035011629 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 585035011630 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 585035011631 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 585035011632 SecA binding site; other site 585035011633 Preprotein binding site; other site 585035011634 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 585035011635 GSH binding site [chemical binding]; other site 585035011636 catalytic residues [active] 585035011637 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 585035011638 active site residue [active] 585035011639 phosphoglyceromutase; Provisional; Region: PRK05434 585035011640 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 585035011641 AmiB activator; Provisional; Region: PRK11637 585035011642 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 585035011643 Peptidase family M23; Region: Peptidase_M23; pfam01551 585035011644 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 585035011645 NodB motif; other site 585035011646 putative active site [active] 585035011647 putative catalytic site [active] 585035011648 Zn binding site [ion binding]; other site 585035011649 putative glycosyl transferase; Provisional; Region: PRK10073 585035011650 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 585035011651 active site 585035011652 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 585035011653 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 585035011654 NAD(P) binding site [chemical binding]; other site 585035011655 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 585035011656 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 585035011657 substrate-cofactor binding pocket; other site 585035011658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035011659 catalytic residue [active] 585035011660 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 585035011661 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 585035011662 NADP binding site [chemical binding]; other site 585035011663 homopentamer interface [polypeptide binding]; other site 585035011664 substrate binding site [chemical binding]; other site 585035011665 active site 585035011666 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 585035011667 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 585035011668 putative active site [active] 585035011669 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 585035011670 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 585035011671 putative active site [active] 585035011672 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 585035011673 O-Antigen ligase; Region: Wzy_C; pfam04932 585035011674 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 585035011675 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 585035011676 active site 585035011677 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 585035011678 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 585035011679 Ligand binding site; other site 585035011680 metal-binding site 585035011681 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 585035011682 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 585035011683 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 585035011684 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 585035011685 Ligand binding site; other site 585035011686 metal-binding site 585035011687 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 585035011688 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 585035011689 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 585035011690 Ligand binding site; other site 585035011691 metal-binding site 585035011692 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 585035011693 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 585035011694 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 585035011695 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 585035011696 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 585035011697 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 585035011698 putative active site [active] 585035011699 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 585035011700 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 585035011701 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 585035011702 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 585035011703 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 585035011704 active site 585035011705 (T/H)XGH motif; other site 585035011706 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 585035011707 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 585035011708 DNA binding site [nucleotide binding] 585035011709 catalytic residue [active] 585035011710 H2TH interface [polypeptide binding]; other site 585035011711 putative catalytic residues [active] 585035011712 turnover-facilitating residue; other site 585035011713 intercalation triad [nucleotide binding]; other site 585035011714 8OG recognition residue [nucleotide binding]; other site 585035011715 putative reading head residues; other site 585035011716 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 585035011717 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 585035011718 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 585035011719 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 585035011720 hypothetical protein; Reviewed; Region: PRK00024 585035011721 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 585035011722 MPN+ (JAMM) motif; other site 585035011723 Zinc-binding site [ion binding]; other site 585035011724 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 585035011725 Flavoprotein; Region: Flavoprotein; pfam02441 585035011726 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 585035011727 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 585035011728 trimer interface [polypeptide binding]; other site 585035011729 active site 585035011730 division inhibitor protein; Provisional; Region: slmA; PRK09480 585035011731 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585035011732 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 585035011733 active site 585035011734 ribonuclease PH; Reviewed; Region: rph; PRK00173 585035011735 Ribonuclease PH; Region: RNase_PH_bact; cd11362 585035011736 hexamer interface [polypeptide binding]; other site 585035011737 active site 585035011738 hypothetical protein; Provisional; Region: PRK11820 585035011739 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 585035011740 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 585035011741 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 585035011742 BRO family, N-terminal domain; Region: Bro-N; pfam02498 585035011743 Predicted membrane protein [Function unknown]; Region: COG2860 585035011744 UPF0126 domain; Region: UPF0126; pfam03458 585035011745 UPF0126 domain; Region: UPF0126; pfam03458 585035011746 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 585035011747 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 585035011748 nucleotide binding pocket [chemical binding]; other site 585035011749 K-X-D-G motif; other site 585035011750 catalytic site [active] 585035011751 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 585035011752 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 585035011753 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 585035011754 catalytic site [active] 585035011755 G-X2-G-X-G-K; other site 585035011756 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 585035011757 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 585035011758 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 585035011759 Zn2+ binding site [ion binding]; other site 585035011760 Mg2+ binding site [ion binding]; other site 585035011761 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 585035011762 synthetase active site [active] 585035011763 NTP binding site [chemical binding]; other site 585035011764 metal binding site [ion binding]; metal-binding site 585035011765 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 585035011766 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 585035011767 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 585035011768 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 585035011769 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 585035011770 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 585035011771 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 585035011772 generic binding surface II; other site 585035011773 ssDNA binding site; other site 585035011774 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585035011775 ATP binding site [chemical binding]; other site 585035011776 putative Mg++ binding site [ion binding]; other site 585035011777 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585035011778 nucleotide binding region [chemical binding]; other site 585035011779 ATP-binding site [chemical binding]; other site 585035011780 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 585035011781 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 585035011782 AsmA family; Region: AsmA; pfam05170 585035011783 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 585035011784 Protein of unknown function (DUF1498); Region: DUF1498; pfam07385 585035011785 fructokinase; Reviewed; Region: PRK09557 585035011786 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585035011787 nucleotide binding site [chemical binding]; other site 585035011788 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 585035011789 intersubunit interface [polypeptide binding]; other site 585035011790 active site 585035011791 zinc binding site [ion binding]; other site 585035011792 Na+ binding site [ion binding]; other site 585035011793 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 585035011794 intersubunit interface [polypeptide binding]; other site 585035011795 active site 585035011796 zinc binding site [ion binding]; other site 585035011797 Na+ binding site [ion binding]; other site 585035011798 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 585035011799 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 585035011800 active site 585035011801 P-loop; other site 585035011802 phosphorylation site [posttranslational modification] 585035011803 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585035011804 active site 585035011805 phosphorylation site [posttranslational modification] 585035011806 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 585035011807 HTH domain; Region: HTH_11; pfam08279 585035011808 Mga helix-turn-helix domain; Region: Mga; pfam05043 585035011809 PRD domain; Region: PRD; pfam00874 585035011810 PRD domain; Region: PRD; pfam00874 585035011811 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 585035011812 active site 585035011813 P-loop; other site 585035011814 phosphorylation site [posttranslational modification] 585035011815 putative alpha-glucosidase; Provisional; Region: PRK10658 585035011816 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 585035011817 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 585035011818 active site 585035011819 homotrimer interface [polypeptide binding]; other site 585035011820 catalytic site [active] 585035011821 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 585035011822 putative transporter; Provisional; Region: PRK11462 585035011823 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 585035011824 Virulence protein [General function prediction only]; Region: COG3943 585035011825 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 585035011826 EamA-like transporter family; Region: EamA; pfam00892 585035011827 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 585035011828 EamA-like transporter family; Region: EamA; pfam00892 585035011829 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 585035011830 lipoprotein, YaeC family; Region: TIGR00363 585035011831 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 585035011832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035011833 putative substrate translocation pore; other site 585035011834 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 585035011835 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 585035011836 cryptic adenine deaminase; Provisional; Region: PRK10027 585035011837 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 585035011838 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 585035011839 active site 585035011840 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 585035011841 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 585035011842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035011843 putative substrate translocation pore; other site 585035011844 regulatory protein UhpC; Provisional; Region: PRK11663 585035011845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035011846 putative substrate translocation pore; other site 585035011847 sensory histidine kinase UhpB; Provisional; Region: PRK11644 585035011848 MASE1; Region: MASE1; pfam05231 585035011849 Histidine kinase; Region: HisKA_3; pfam07730 585035011850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035011851 ATP binding site [chemical binding]; other site 585035011852 Mg2+ binding site [ion binding]; other site 585035011853 G-X-G motif; other site 585035011854 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 585035011855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035011856 active site 585035011857 phosphorylation site [posttranslational modification] 585035011858 intermolecular recognition site; other site 585035011859 dimerization interface [polypeptide binding]; other site 585035011860 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585035011861 DNA binding residues [nucleotide binding] 585035011862 dimerization interface [polypeptide binding]; other site 585035011863 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 585035011864 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 585035011865 putative valine binding site [chemical binding]; other site 585035011866 dimer interface [polypeptide binding]; other site 585035011867 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 585035011868 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 585035011869 PYR/PP interface [polypeptide binding]; other site 585035011870 dimer interface [polypeptide binding]; other site 585035011871 TPP binding site [chemical binding]; other site 585035011872 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 585035011873 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 585035011874 TPP-binding site [chemical binding]; other site 585035011875 dimer interface [polypeptide binding]; other site 585035011876 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 585035011877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035011878 putative substrate translocation pore; other site 585035011879 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 585035011880 Domain of unknown function (DUF202); Region: DUF202; pfam02656 585035011881 Predicted membrane protein [Function unknown]; Region: COG2149 585035011882 Evidence 7 : Gene remnant; Product type pe : enzyme 585035011883 Evidence 7 : Gene remnant; Product type pe : enzyme 585035011884 Evidence 7 : Gene remnant; Product type t : transporter 585035011885 Evidence 7 : Gene remnant; Product type t : transporter 585035011886 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 585035011887 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035011888 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585035011889 putative transporter; Validated; Region: PRK03818 585035011890 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 585035011891 TrkA-C domain; Region: TrkA_C; pfam02080 585035011892 TrkA-C domain; Region: TrkA_C; pfam02080 585035011893 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 585035011894 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 585035011895 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 585035011896 putative dimer interface [polypeptide binding]; other site 585035011897 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 585035011898 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 585035011899 putative dimer interface [polypeptide binding]; other site 585035011900 hypothetical protein; Provisional; Region: PRK11616 585035011901 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 585035011902 putative oxidoreductase; Provisional; Region: PRK11445 585035011903 hypothetical protein; Provisional; Region: PRK07236 585035011904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035011905 D-galactonate transporter; Region: 2A0114; TIGR00893 585035011906 putative substrate translocation pore; other site 585035011907 galactonate dehydratase; Provisional; Region: PRK14017 585035011908 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 585035011909 putative active site pocket [active] 585035011910 putative metal binding site [ion binding]; other site 585035011911 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 585035011912 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 585035011913 active site 585035011914 intersubunit interface [polypeptide binding]; other site 585035011915 catalytic residue [active] 585035011916 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 585035011917 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 585035011918 Transcriptional regulators [Transcription]; Region: FadR; COG2186 585035011919 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585035011920 DNA-binding site [nucleotide binding]; DNA binding site 585035011921 FCD domain; Region: FCD; pfam07729 585035011922 hypothetical protein; Provisional; Region: PRK10215 585035011923 sugar phosphate phosphatase; Provisional; Region: PRK10513 585035011924 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585035011925 active site 585035011926 motif I; other site 585035011927 motif II; other site 585035011928 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585035011929 hypothetical protein; Provisional; Region: PRK11426 585035011930 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 585035011931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035011932 Mg2+ binding site [ion binding]; other site 585035011933 G-X-G motif; other site 585035011934 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 585035011935 anchoring element; other site 585035011936 dimer interface [polypeptide binding]; other site 585035011937 ATP binding site [chemical binding]; other site 585035011938 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 585035011939 active site 585035011940 putative metal-binding site [ion binding]; other site 585035011941 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 585035011942 recF protein; Region: recf; TIGR00611 585035011943 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585035011944 Walker A/P-loop; other site 585035011945 ATP binding site [chemical binding]; other site 585035011946 Q-loop/lid; other site 585035011947 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585035011948 ABC transporter signature motif; other site 585035011949 Walker B; other site 585035011950 D-loop; other site 585035011951 H-loop/switch region; other site 585035011952 DNA polymerase III subunit beta; Validated; Region: PRK05643 585035011953 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 585035011954 putative DNA binding surface [nucleotide binding]; other site 585035011955 dimer interface [polypeptide binding]; other site 585035011956 beta-clamp/clamp loader binding surface; other site 585035011957 beta-clamp/translesion DNA polymerase binding surface; other site 585035011958 DnaA N-terminal domain; Region: DnaA_N; pfam11638 585035011959 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 585035011960 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035011961 Walker A motif; other site 585035011962 ATP binding site [chemical binding]; other site 585035011963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 585035011964 Walker B motif; other site 585035011965 arginine finger; other site 585035011966 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 585035011967 DnaA box-binding interface [nucleotide binding]; other site 585035011968 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 585035011969 ribonuclease P; Reviewed; Region: rnpA; PRK01732 585035011970 hypothetical protein; Validated; Region: PRK00041 585035011971 membrane protein insertase; Provisional; Region: PRK01318 585035011972 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 585035011973 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 585035011974 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 585035011975 trmE is a tRNA modification GTPase; Region: trmE; cd04164 585035011976 G1 box; other site 585035011977 GTP/Mg2+ binding site [chemical binding]; other site 585035011978 Switch I region; other site 585035011979 G2 box; other site 585035011980 Switch II region; other site 585035011981 G3 box; other site 585035011982 G4 box; other site 585035011983 G5 box; other site 585035011984 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 585035011985 Tryptophanese operon leader peptide; Region: Tna_leader; pfam08053 585035011986 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 585035011987 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 585035011988 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 585035011989 catalytic residue [active] 585035011990 tryptophan permease TnaB; Provisional; Region: PRK09664 585035011991 aromatic amino acid transport protein; Region: araaP; TIGR00837 585035011992 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 585035011993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035011994 putative substrate translocation pore; other site 585035011995 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 585035011996 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035011997 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 585035011998 substrate binding pocket [chemical binding]; other site 585035011999 dimerization interface [polypeptide binding]; other site 585035012000 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 585035012001 Predicted flavoprotein [General function prediction only]; Region: COG0431 585035012002 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 585035012003 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 585035012004 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 585035012005 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585035012006 active site 585035012007 motif I; other site 585035012008 motif II; other site 585035012009 putative inner membrane protein; Provisional; Region: PRK09823 585035012010 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 585035012011 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 585035012012 active site 585035012013 trimer interface [polypeptide binding]; other site 585035012014 allosteric site; other site 585035012015 active site lid [active] 585035012016 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 585035012017 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 585035012018 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 585035012019 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 585035012020 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 585035012021 trimer interface; other site 585035012022 sugar binding site [chemical binding]; other site 585035012023 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 585035012024 beta-galactosidase; Region: BGL; TIGR03356 585035012025 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 585035012026 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585035012027 active site turn [active] 585035012028 phosphorylation site [posttranslational modification] 585035012029 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 585035012030 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 585035012031 HPr interaction site; other site 585035012032 glycerol kinase (GK) interaction site [polypeptide binding]; other site 585035012033 active site 585035012034 phosphorylation site [posttranslational modification] 585035012035 transcriptional antiterminator BglG; Provisional; Region: PRK09772 585035012036 CAT RNA binding domain; Region: CAT_RBD; pfam03123 585035012037 PRD domain; Region: PRD; pfam00874 585035012038 PRD domain; Region: PRD; pfam00874 585035012039 transcriptional regulator PhoU; Provisional; Region: PRK11115 585035012040 PhoU domain; Region: PhoU; pfam01895 585035012041 PhoU domain; Region: PhoU; pfam01895 585035012042 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 585035012043 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 585035012044 Walker A/P-loop; other site 585035012045 ATP binding site [chemical binding]; other site 585035012046 Q-loop/lid; other site 585035012047 ABC transporter signature motif; other site 585035012048 Walker B; other site 585035012049 D-loop; other site 585035012050 H-loop/switch region; other site 585035012051 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 585035012052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035012053 dimer interface [polypeptide binding]; other site 585035012054 conserved gate region; other site 585035012055 putative PBP binding loops; other site 585035012056 ABC-ATPase subunit interface; other site 585035012057 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 585035012058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035012059 dimer interface [polypeptide binding]; other site 585035012060 conserved gate region; other site 585035012061 putative PBP binding loops; other site 585035012062 ABC-ATPase subunit interface; other site 585035012063 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585035012064 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 585035012065 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 585035012066 glutaminase active site [active] 585035012067 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 585035012068 dimer interface [polypeptide binding]; other site 585035012069 active site 585035012070 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 585035012071 dimer interface [polypeptide binding]; other site 585035012072 active site 585035012073 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 585035012074 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 585035012075 Substrate binding site; other site 585035012076 Mg++ binding site; other site 585035012077 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 585035012078 active site 585035012079 substrate binding site [chemical binding]; other site 585035012080 CoA binding site [chemical binding]; other site 585035012081 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 585035012082 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 585035012083 gamma subunit interface [polypeptide binding]; other site 585035012084 epsilon subunit interface [polypeptide binding]; other site 585035012085 LBP interface [polypeptide binding]; other site 585035012086 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 585035012087 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 585035012088 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 585035012089 alpha subunit interaction interface [polypeptide binding]; other site 585035012090 Walker A motif; other site 585035012091 ATP binding site [chemical binding]; other site 585035012092 Walker B motif; other site 585035012093 inhibitor binding site; inhibition site 585035012094 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 585035012095 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 585035012096 core domain interface [polypeptide binding]; other site 585035012097 delta subunit interface [polypeptide binding]; other site 585035012098 epsilon subunit interface [polypeptide binding]; other site 585035012099 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 585035012100 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 585035012101 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 585035012102 beta subunit interaction interface [polypeptide binding]; other site 585035012103 Walker A motif; other site 585035012104 ATP binding site [chemical binding]; other site 585035012105 Walker B motif; other site 585035012106 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 585035012107 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 585035012108 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 585035012109 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 585035012110 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 585035012111 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 585035012112 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 585035012113 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 585035012114 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 585035012115 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 585035012116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035012117 S-adenosylmethionine binding site [chemical binding]; other site 585035012118 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 585035012119 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 585035012120 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 585035012121 FMN-binding protein MioC; Provisional; Region: PRK09004 585035012122 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 585035012123 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585035012124 putative DNA binding site [nucleotide binding]; other site 585035012125 putative Zn2+ binding site [ion binding]; other site 585035012126 AsnC family; Region: AsnC_trans_reg; pfam01037 585035012127 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 585035012128 dimer interface [polypeptide binding]; other site 585035012129 active site 585035012130 hypothetical protein; Provisional; Region: yieM; PRK10997 585035012131 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 585035012132 metal ion-dependent adhesion site (MIDAS); other site 585035012133 regulatory ATPase RavA; Provisional; Region: PRK13531 585035012134 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035012135 Walker A motif; other site 585035012136 ATP binding site [chemical binding]; other site 585035012137 Walker B motif; other site 585035012138 arginine finger; other site 585035012139 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 585035012140 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 585035012141 potassium uptake protein; Region: kup; TIGR00794 585035012142 D-ribose pyranase; Provisional; Region: PRK11797 585035012143 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 585035012144 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585035012145 Walker A/P-loop; other site 585035012146 ATP binding site [chemical binding]; other site 585035012147 Q-loop/lid; other site 585035012148 ABC transporter signature motif; other site 585035012149 Walker B; other site 585035012150 D-loop; other site 585035012151 H-loop/switch region; other site 585035012152 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585035012153 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585035012154 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585035012155 TM-ABC transporter signature motif; other site 585035012156 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 585035012157 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 585035012158 ligand binding site [chemical binding]; other site 585035012159 dimerization interface [polypeptide binding]; other site 585035012160 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 585035012161 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585035012162 substrate binding site [chemical binding]; other site 585035012163 dimer interface [polypeptide binding]; other site 585035012164 ATP binding site [chemical binding]; other site 585035012165 transcriptional repressor RbsR; Provisional; Region: PRK10423 585035012166 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585035012167 DNA binding site [nucleotide binding] 585035012168 domain linker motif; other site 585035012169 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 585035012170 dimerization interface [polypeptide binding]; other site 585035012171 ligand binding site [chemical binding]; other site 585035012172 putative transporter; Provisional; Region: PRK10504 585035012173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035012174 putative substrate translocation pore; other site 585035012175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035012176 Transcriptional regulators [Transcription]; Region: FadR; COG2186 585035012177 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585035012178 DNA-binding site [nucleotide binding]; DNA binding site 585035012179 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585035012180 transcriptional regulator HdfR; Provisional; Region: PRK03601 585035012181 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035012182 LysR substrate binding domain; Region: LysR_substrate; pfam03466 585035012183 dimerization interface [polypeptide binding]; other site 585035012184 hypothetical protein; Provisional; Region: PRK11027 585035012185 putative ATP-dependent protease; Provisional; Region: PRK09862 585035012186 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 585035012187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035012188 Walker A motif; other site 585035012189 ATP binding site [chemical binding]; other site 585035012190 Walker B motif; other site 585035012191 arginine finger; other site 585035012192 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 585035012193 ilvG operon leader peptide; Provisional; Region: PRK10424 585035012194 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 585035012195 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 585035012196 PYR/PP interface [polypeptide binding]; other site 585035012197 dimer interface [polypeptide binding]; other site 585035012198 TPP binding site [chemical binding]; other site 585035012199 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 585035012200 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 585035012201 TPP-binding site [chemical binding]; other site 585035012202 dimer interface [polypeptide binding]; other site 585035012203 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 585035012204 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 585035012205 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 585035012206 homodimer interface [polypeptide binding]; other site 585035012207 substrate-cofactor binding pocket; other site 585035012208 catalytic residue [active] 585035012209 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 585035012210 threonine dehydratase; Reviewed; Region: PRK09224 585035012211 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 585035012212 tetramer interface [polypeptide binding]; other site 585035012213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035012214 catalytic residue [active] 585035012215 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 585035012216 putative Ile/Val binding site [chemical binding]; other site 585035012217 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 585035012218 putative Ile/Val binding site [chemical binding]; other site 585035012219 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035012220 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 585035012221 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 585035012222 putative dimerization interface [polypeptide binding]; other site 585035012223 ketol-acid reductoisomerase; Validated; Region: PRK05225 585035012224 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 585035012225 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 585035012226 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 585035012227 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 585035012228 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 585035012229 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 585035012230 Part of AAA domain; Region: AAA_19; pfam13245 585035012231 Family description; Region: UvrD_C_2; pfam13538 585035012232 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 585035012233 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 585035012234 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 585035012235 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 585035012236 ATP binding site [chemical binding]; other site 585035012237 Mg++ binding site [ion binding]; other site 585035012238 motif III; other site 585035012239 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 585035012240 nucleotide binding region [chemical binding]; other site 585035012241 ATP-binding site [chemical binding]; other site 585035012242 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 585035012243 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 585035012244 catalytic residues [active] 585035012245 putative rho operon leader peptide; Provisional; Region: PRK09979 585035012246 transcription termination factor Rho; Provisional; Region: rho; PRK09376 585035012247 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 585035012248 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 585035012249 RNA binding site [nucleotide binding]; other site 585035012250 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 585035012251 multimer interface [polypeptide binding]; other site 585035012252 Walker A motif; other site 585035012253 ATP binding site [chemical binding]; other site 585035012254 Walker B motif; other site 585035012255 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 585035012256 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 585035012257 Mg++ binding site [ion binding]; other site 585035012258 putative catalytic motif [active] 585035012259 substrate binding site [chemical binding]; other site 585035012260 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 585035012261 Chain length determinant protein; Region: Wzz; pfam02706 585035012262 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 585035012263 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 585035012264 active site 585035012265 homodimer interface [polypeptide binding]; other site 585035012266 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 585035012267 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 585035012268 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 585035012269 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 585035012270 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 585035012271 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 585035012272 NAD binding site [chemical binding]; other site 585035012273 substrate binding site [chemical binding]; other site 585035012274 homodimer interface [polypeptide binding]; other site 585035012275 active site 585035012276 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 585035012277 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 585035012278 substrate binding site; other site 585035012279 tetramer interface; other site 585035012280 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 585035012281 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 585035012282 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 585035012283 inhibitor-cofactor binding pocket; inhibition site 585035012284 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035012285 catalytic residue [active] 585035012286 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 585035012287 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 585035012288 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 585035012289 putative common antigen polymerase; Provisional; Region: PRK02975 585035012290 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 585035012291 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 585035012292 putative transport protein YifK; Provisional; Region: PRK10746 585035012293 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 585035012294 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585035012295 FeS/SAM binding site; other site 585035012296 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 585035012297 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 585035012298 Sulfatase; Region: Sulfatase; pfam00884 585035012299 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 585035012300 HemY protein N-terminus; Region: HemY_N; pfam07219 585035012301 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 585035012302 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 585035012303 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 585035012304 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 585035012305 active site 585035012306 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 585035012307 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 585035012308 domain interfaces; other site 585035012309 active site 585035012310 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 585035012311 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 585035012312 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 585035012313 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 585035012314 putative iron binding site [ion binding]; other site 585035012315 Evidence 7 : Gene remnant 585035012316 Evidence 7 : Gene remnant 585035012317 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 585035012318 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 585035012319 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 585035012320 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 585035012321 hypothetical protein; Provisional; Region: PRK10963 585035012322 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 585035012323 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 585035012324 active site 585035012325 DNA binding site [nucleotide binding] 585035012326 Int/Topo IB signature motif; other site 585035012327 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 585035012328 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585035012329 motif II; other site 585035012330 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 585035012331 Part of AAA domain; Region: AAA_19; pfam13245 585035012332 Family description; Region: UvrD_C_2; pfam13538 585035012333 Uncharacterized conserved protein [Function unknown]; Region: COG1912 585035012334 Predicted periplasmic protein [Function unknown]; Region: COG3698 585035012335 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 585035012336 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 585035012337 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 585035012338 Cl binding site [ion binding]; other site 585035012339 oligomer interface [polypeptide binding]; other site 585035012340 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 585035012341 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 585035012342 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 585035012343 EamA-like transporter family; Region: EamA; cl17759 585035012344 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 585035012345 CoenzymeA binding site [chemical binding]; other site 585035012346 subunit interaction site [polypeptide binding]; other site 585035012347 PHB binding site; other site 585035012348 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 585035012349 dimerization interface [polypeptide binding]; other site 585035012350 substrate binding site [chemical binding]; other site 585035012351 active site 585035012352 calcium binding site [ion binding]; other site 585035012353 Evidence 7 : Gene remnant; Product type e : enzyme 585035012354 Evidence 7 : Gene remnant; Product type e : enzyme 585035012355 threonine efflux system; Provisional; Region: PRK10229 585035012356 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 585035012357 lysophospholipase L2; Provisional; Region: PRK10749 585035012358 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 585035012359 putative hydrolase; Provisional; Region: PRK10976 585035012360 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585035012361 active site 585035012362 motif I; other site 585035012363 motif II; other site 585035012364 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585035012365 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 585035012366 EamA-like transporter family; Region: EamA; pfam00892 585035012367 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 585035012368 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035012369 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 585035012370 putative dimerization interface [polypeptide binding]; other site 585035012371 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 585035012372 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 585035012373 THF binding site; other site 585035012374 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 585035012375 substrate binding site [chemical binding]; other site 585035012376 THF binding site; other site 585035012377 zinc-binding site [ion binding]; other site 585035012378 Evidence 7 : Gene remnant 585035012379 Evidence 7 : Gene remnant 585035012380 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 585035012381 tetramer interface [polypeptide binding]; other site 585035012382 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 585035012383 active site 585035012384 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 585035012385 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 585035012386 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585035012387 active site turn [active] 585035012388 phosphorylation site [posttranslational modification] 585035012389 transketolase; Reviewed; Region: PRK12753 585035012390 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 585035012391 TPP-binding site [chemical binding]; other site 585035012392 dimer interface [polypeptide binding]; other site 585035012393 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 585035012394 PYR/PP interface [polypeptide binding]; other site 585035012395 dimer interface [polypeptide binding]; other site 585035012396 TPP binding site [chemical binding]; other site 585035012397 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 585035012398 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 585035012399 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 585035012400 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 585035012401 putative active site [active] 585035012402 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 585035012403 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035012404 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 585035012405 dimerization interface [polypeptide binding]; other site 585035012406 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 585035012407 Na binding site [ion binding]; other site 585035012408 allophanate hydrolase; Provisional; Region: PRK08186 585035012409 carbamate kinase; Reviewed; Region: PRK12686 585035012410 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 585035012411 putative substrate binding site [chemical binding]; other site 585035012412 nucleotide binding site [chemical binding]; other site 585035012413 nucleotide binding site [chemical binding]; other site 585035012414 homodimer interface [polypeptide binding]; other site 585035012415 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 585035012416 CoA binding domain; Region: CoA_binding; pfam02629 585035012417 CoA-ligase; Region: Ligase_CoA; pfam00549 585035012418 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 585035012419 Isochorismatase family; Region: Isochorismatase; pfam00857 585035012420 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 585035012421 catalytic triad [active] 585035012422 conserved cis-peptide bond; other site 585035012423 Dienelactone hydrolase family; Region: DLH; pfam01738 585035012424 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 585035012425 uridine phosphorylase; Provisional; Region: PRK11178 585035012426 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 585035012427 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 585035012428 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 585035012429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 585035012430 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 585035012431 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 585035012432 active site 585035012433 intersubunit interface [polypeptide binding]; other site 585035012434 catalytic residue [active] 585035012435 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 585035012436 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 585035012437 Transcriptional regulator [Transcription]; Region: IclR; COG1414 585035012438 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 585035012439 Bacterial transcriptional regulator; Region: IclR; pfam01614 585035012440 DNA recombination protein RmuC; Provisional; Region: PRK10361 585035012441 RmuC family; Region: RmuC; pfam02646 585035012442 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 585035012443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035012444 S-adenosylmethionine binding site [chemical binding]; other site 585035012445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 585035012446 SCP-2 sterol transfer family; Region: SCP2; pfam02036 585035012447 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 585035012448 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 585035012449 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 585035012450 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 585035012451 sec-independent translocase; Provisional; Region: PRK01770 585035012452 sec-independent translocase; Provisional; Region: tatB; PRK00404 585035012453 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 585035012454 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 585035012455 active site 585035012456 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 585035012457 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 585035012458 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 585035012459 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 585035012460 FMN reductase; Validated; Region: fre; PRK08051 585035012461 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 585035012462 FAD binding pocket [chemical binding]; other site 585035012463 FAD binding motif [chemical binding]; other site 585035012464 phosphate binding motif [ion binding]; other site 585035012465 beta-alpha-beta structure motif; other site 585035012466 NAD binding pocket [chemical binding]; other site 585035012467 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 585035012468 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 585035012469 dimer interface [polypeptide binding]; other site 585035012470 active site 585035012471 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 585035012472 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585035012473 substrate binding site [chemical binding]; other site 585035012474 oxyanion hole (OAH) forming residues; other site 585035012475 trimer interface [polypeptide binding]; other site 585035012476 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 585035012477 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 585035012478 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 585035012479 proline dipeptidase; Provisional; Region: PRK13607 585035012480 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 585035012481 active site 585035012482 hypothetical protein; Provisional; Region: PRK11568 585035012483 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 585035012484 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 585035012485 potassium transporter; Provisional; Region: PRK10750 585035012486 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 585035012487 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 585035012488 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 585035012489 Walker A motif; other site 585035012490 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 585035012491 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 585035012492 GTP binding site; other site 585035012493 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 585035012494 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 585035012495 serine/threonine protein kinase; Provisional; Region: PRK11768 585035012496 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 585035012497 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 585035012498 catalytic residues [active] 585035012499 hinge region; other site 585035012500 alpha helical domain; other site 585035012501 hypothetical protein; Provisional; Region: PRK11367 585035012502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 585035012503 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 585035012504 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 585035012505 putative acyl-acceptor binding pocket; other site 585035012506 DNA polymerase I; Provisional; Region: PRK05755 585035012507 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 585035012508 active site 585035012509 metal binding site 1 [ion binding]; metal-binding site 585035012510 putative 5' ssDNA interaction site; other site 585035012511 metal binding site 3; metal-binding site 585035012512 metal binding site 2 [ion binding]; metal-binding site 585035012513 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 585035012514 putative DNA binding site [nucleotide binding]; other site 585035012515 putative metal binding site [ion binding]; other site 585035012516 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 585035012517 active site 585035012518 catalytic site [active] 585035012519 substrate binding site [chemical binding]; other site 585035012520 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 585035012521 active site 585035012522 DNA binding site [nucleotide binding] 585035012523 catalytic site [active] 585035012524 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 585035012525 G1 box; other site 585035012526 GTP/Mg2+ binding site [chemical binding]; other site 585035012527 Switch I region; other site 585035012528 G2 box; other site 585035012529 G3 box; other site 585035012530 Switch II region; other site 585035012531 G4 box; other site 585035012532 G5 box; other site 585035012533 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 585035012534 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 585035012535 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585035012536 FeS/SAM binding site; other site 585035012537 HemN C-terminal domain; Region: HemN_C; pfam06969 585035012538 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 585035012539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035012540 active site 585035012541 phosphorylation site [posttranslational modification] 585035012542 intermolecular recognition site; other site 585035012543 dimerization interface [polypeptide binding]; other site 585035012544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035012545 Walker A motif; other site 585035012546 ATP binding site [chemical binding]; other site 585035012547 Walker B motif; other site 585035012548 arginine finger; other site 585035012549 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585035012550 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 585035012551 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 585035012552 putative active site [active] 585035012553 heme pocket [chemical binding]; other site 585035012554 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585035012555 dimer interface [polypeptide binding]; other site 585035012556 phosphorylation site [posttranslational modification] 585035012557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035012558 ATP binding site [chemical binding]; other site 585035012559 Mg2+ binding site [ion binding]; other site 585035012560 G-X-G motif; other site 585035012561 glutamine synthetase; Provisional; Region: glnA; PRK09469 585035012562 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 585035012563 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 585035012564 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 585035012565 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 585035012566 G1 box; other site 585035012567 putative GEF interaction site [polypeptide binding]; other site 585035012568 GTP/Mg2+ binding site [chemical binding]; other site 585035012569 Switch I region; other site 585035012570 G2 box; other site 585035012571 G3 box; other site 585035012572 Switch II region; other site 585035012573 G4 box; other site 585035012574 G5 box; other site 585035012575 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 585035012576 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 585035012577 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 585035012578 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585035012579 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585035012580 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 585035012581 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 585035012582 substrate binding site [chemical binding]; other site 585035012583 ATP binding site [chemical binding]; other site 585035012584 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 585035012585 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 585035012586 Class I aldolases; Region: Aldolase_Class_I; cl17187 585035012587 catalytic residue [active] 585035012588 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 585035012589 putative oxidoreductase; Provisional; Region: PRK10083 585035012590 NAD(P) binding site [chemical binding]; other site 585035012591 benzoate transport; Region: 2A0115; TIGR00895 585035012592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035012593 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035012594 shikimate transporter; Provisional; Region: PRK09952 585035012595 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035012596 putative substrate translocation pore; other site 585035012597 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 585035012598 active site 585035012599 catalytic residues [active] 585035012600 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 585035012601 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585035012602 motif II; other site 585035012603 hypothetical protein; Reviewed; Region: PRK01637 585035012604 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 585035012605 putative active site [active] 585035012606 dimerization interface [polypeptide binding]; other site 585035012607 putative tRNAtyr binding site [nucleotide binding]; other site 585035012608 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585035012609 Coenzyme A binding pocket [chemical binding]; other site 585035012610 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 585035012611 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 585035012612 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 585035012613 substrate binding pocket [chemical binding]; other site 585035012614 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585035012615 non-specific DNA binding site [nucleotide binding]; other site 585035012616 salt bridge; other site 585035012617 sequence-specific DNA binding site [nucleotide binding]; other site 585035012618 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 585035012619 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 585035012620 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 585035012621 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 585035012622 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 585035012623 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 585035012624 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 585035012625 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 585035012626 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 585035012627 [4Fe-4S] binding site [ion binding]; other site 585035012628 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 585035012629 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 585035012630 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 585035012631 molybdopterin cofactor binding site; other site 585035012632 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 585035012633 Evidence 7 : Gene remnant 585035012634 Evidence 7 : Gene remnant 585035012635 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 585035012636 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 585035012637 intersubunit interface [polypeptide binding]; other site 585035012638 active site 585035012639 Zn2+ binding site [ion binding]; other site 585035012640 L-rhamnose isomerase; Provisional; Region: PRK01076 585035012641 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 585035012642 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 585035012643 N- and C-terminal domain interface [polypeptide binding]; other site 585035012644 active site 585035012645 putative catalytic site [active] 585035012646 metal binding site [ion binding]; metal-binding site 585035012647 ATP binding site [chemical binding]; other site 585035012648 rhamnulokinase; Provisional; Region: rhaB; PRK10640 585035012649 carbohydrate binding site [chemical binding]; other site 585035012650 transcriptional activator RhaS; Provisional; Region: PRK13503 585035012651 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 585035012652 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035012653 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035012654 Evidence 7 : Gene remnant; Product type r : regulator 585035012655 Evidence 7 : Gene remnant; Product type r : regulator 585035012656 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 585035012657 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 585035012658 superoxide dismutase; Provisional; Region: PRK10925 585035012659 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 585035012660 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 585035012661 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 585035012662 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 585035012663 MOSC domain; Region: MOSC; pfam03473 585035012664 3-alpha domain; Region: 3-alpha; pfam03475 585035012665 two-component sensor protein; Provisional; Region: cpxA; PRK09470 585035012666 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585035012667 dimerization interface [polypeptide binding]; other site 585035012668 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585035012669 dimer interface [polypeptide binding]; other site 585035012670 phosphorylation site [posttranslational modification] 585035012671 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035012672 ATP binding site [chemical binding]; other site 585035012673 Mg2+ binding site [ion binding]; other site 585035012674 G-X-G motif; other site 585035012675 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 585035012676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035012677 active site 585035012678 intermolecular recognition site; other site 585035012679 dimerization interface [polypeptide binding]; other site 585035012680 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585035012681 DNA binding site [nucleotide binding] 585035012682 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 585035012683 dimer interface [polypeptide binding]; other site 585035012684 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 585035012685 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 585035012686 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 585035012687 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 585035012688 active site 585035012689 ADP/pyrophosphate binding site [chemical binding]; other site 585035012690 dimerization interface [polypeptide binding]; other site 585035012691 allosteric effector site; other site 585035012692 fructose-1,6-bisphosphate binding site; other site 585035012693 sulfate transporter subunit; Provisional; Region: PRK10752 585035012694 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 585035012695 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 585035012696 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 585035012697 triosephosphate isomerase; Provisional; Region: PRK14567 585035012698 substrate binding site [chemical binding]; other site 585035012699 dimer interface [polypeptide binding]; other site 585035012700 catalytic triad [active] 585035012701 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 585035012702 Predicted membrane protein [Function unknown]; Region: COG3152 585035012703 hypothetical protein; Provisional; Region: PRK09981 585035012704 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 585035012705 Ligand Binding Site [chemical binding]; other site 585035012706 ferredoxin-NADP reductase; Provisional; Region: PRK10926 585035012707 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 585035012708 FAD binding pocket [chemical binding]; other site 585035012709 FAD binding motif [chemical binding]; other site 585035012710 phosphate binding motif [ion binding]; other site 585035012711 beta-alpha-beta structure motif; other site 585035012712 NAD binding pocket [chemical binding]; other site 585035012713 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 585035012714 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 585035012715 putative active site [active] 585035012716 glycerol kinase; Provisional; Region: glpK; PRK00047 585035012717 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 585035012718 N- and C-terminal domain interface [polypeptide binding]; other site 585035012719 active site 585035012720 MgATP binding site [chemical binding]; other site 585035012721 catalytic site [active] 585035012722 metal binding site [ion binding]; metal-binding site 585035012723 glycerol binding site [chemical binding]; other site 585035012724 homotetramer interface [polypeptide binding]; other site 585035012725 homodimer interface [polypeptide binding]; other site 585035012726 FBP binding site [chemical binding]; other site 585035012727 protein IIAGlc interface [polypeptide binding]; other site 585035012728 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 585035012729 amphipathic channel; other site 585035012730 Asn-Pro-Ala signature motifs; other site 585035012731 septal ring assembly protein ZapB; Provisional; Region: PRK15422 585035012732 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 585035012733 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 585035012734 UbiA prenyltransferase family; Region: UbiA; pfam01040 585035012735 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 585035012736 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035012737 Walker A motif; other site 585035012738 ATP binding site [chemical binding]; other site 585035012739 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 585035012740 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 585035012741 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 585035012742 active site 585035012743 HslU subunit interaction site [polypeptide binding]; other site 585035012744 essential cell division protein FtsN; Provisional; Region: PRK10927 585035012745 cell division protein FtsN; Provisional; Region: PRK12757 585035012746 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585035012747 DNA binding site [nucleotide binding] 585035012748 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 585035012749 domain linker motif; other site 585035012750 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 585035012751 dimerization interface [polypeptide binding]; other site 585035012752 ligand binding site [chemical binding]; other site 585035012753 primosome assembly protein PriA; Validated; Region: PRK05580 585035012754 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 585035012755 ATP binding site [chemical binding]; other site 585035012756 putative Mg++ binding site [ion binding]; other site 585035012757 helicase superfamily c-terminal domain; Region: HELICc; smart00490 585035012758 ATP-binding site [chemical binding]; other site 585035012759 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 585035012760 hypothetical protein; Provisional; Region: PRK10030 585035012761 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 585035012762 dimerization interface [polypeptide binding]; other site 585035012763 DNA binding site [nucleotide binding] 585035012764 corepressor binding sites; other site 585035012765 cystathionine gamma-synthase; Provisional; Region: PRK08045 585035012766 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 585035012767 homodimer interface [polypeptide binding]; other site 585035012768 substrate-cofactor binding pocket; other site 585035012769 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035012770 catalytic residue [active] 585035012771 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 585035012772 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 585035012773 putative catalytic residues [active] 585035012774 putative nucleotide binding site [chemical binding]; other site 585035012775 putative aspartate binding site [chemical binding]; other site 585035012776 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 585035012777 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 585035012778 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 585035012779 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 585035012780 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 585035012781 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 585035012782 active site 585035012783 metal binding site [ion binding]; metal-binding site 585035012784 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 585035012785 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 585035012786 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 585035012787 active site 585035012788 metal binding site [ion binding]; metal-binding site 585035012789 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 585035012790 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 585035012791 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 585035012792 active site 585035012793 metal binding site [ion binding]; metal-binding site 585035012794 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 585035012795 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 585035012796 FAD binding site [chemical binding]; other site 585035012797 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 585035012798 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 585035012799 heme binding site [chemical binding]; other site 585035012800 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 585035012801 EamA-like transporter family; Region: EamA; pfam00892 585035012802 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 585035012803 EamA-like transporter family; Region: EamA; pfam00892 585035012804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 585035012805 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 585035012806 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 585035012807 dimer interface [polypeptide binding]; other site 585035012808 active site 585035012809 metal binding site [ion binding]; metal-binding site 585035012810 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 585035012811 active site 585035012812 intersubunit interactions; other site 585035012813 catalytic residue [active] 585035012814 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 585035012815 dimerization domain swap beta strand [polypeptide binding]; other site 585035012816 regulatory protein interface [polypeptide binding]; other site 585035012817 active site 585035012818 regulatory phosphorylation site [posttranslational modification]; other site 585035012819 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 585035012820 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 585035012821 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 585035012822 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 585035012823 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585035012824 active site 585035012825 phosphorylation site [posttranslational modification] 585035012826 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 585035012827 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 585035012828 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 585035012829 active site 585035012830 P-loop; other site 585035012831 phosphorylation site [posttranslational modification] 585035012832 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 585035012833 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 585035012834 dimer interface [polypeptide binding]; other site 585035012835 active site 585035012836 glycine loop; other site 585035012837 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 585035012838 FeS/SAM binding site; other site 585035012839 pyruvate formate lyase II activase; Provisional; Region: PRK10076 585035012840 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 585035012841 active site 585035012842 P-loop; other site 585035012843 phosphorylation site [posttranslational modification] 585035012844 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585035012845 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035012846 hypothetical protein; Provisional; Region: PRK10649 585035012847 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 585035012848 Sulfatase; Region: Sulfatase; pfam00884 585035012849 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 585035012850 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 585035012851 acetylornithine deacetylase; Provisional; Region: PRK05111 585035012852 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 585035012853 metal binding site [ion binding]; metal-binding site 585035012854 putative dimer interface [polypeptide binding]; other site 585035012855 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 585035012856 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 585035012857 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 585035012858 nucleotide binding site [chemical binding]; other site 585035012859 N-acetyl-L-glutamate binding site [chemical binding]; other site 585035012860 argininosuccinate lyase; Provisional; Region: PRK04833 585035012861 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 585035012862 active sites [active] 585035012863 tetramer interface [polypeptide binding]; other site 585035012864 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 585035012865 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 585035012866 putative active site pocket [active] 585035012867 putative metal binding site [ion binding]; other site 585035012868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035012869 D-galactonate transporter; Region: 2A0114; TIGR00893 585035012870 putative substrate translocation pore; other site 585035012871 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 585035012872 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035012873 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 585035012874 dimerization interface [polypeptide binding]; other site 585035012875 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 585035012876 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585035012877 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 585035012878 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 585035012879 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 585035012880 metal binding site [ion binding]; metal-binding site 585035012881 putative dimer interface [polypeptide binding]; other site 585035012882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035012883 metabolite-proton symporter; Region: 2A0106; TIGR00883 585035012884 putative substrate translocation pore; other site 585035012885 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 585035012886 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585035012887 hypothetical protein; Provisional; Region: PRK11056 585035012888 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 585035012889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035012890 S-adenosylmethionine binding site [chemical binding]; other site 585035012891 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 585035012892 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585035012893 N-terminal plug; other site 585035012894 ligand-binding site [chemical binding]; other site 585035012895 glutamate racemase; Provisional; Region: PRK00865 585035012896 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 585035012897 FAD binding domain; Region: FAD_binding_4; pfam01565 585035012898 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 585035012899 Biotin operon repressor [Transcription]; Region: BirA; COG1654 585035012900 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 585035012901 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 585035012902 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 585035012903 pantothenate kinase; Provisional; Region: PRK05439 585035012904 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 585035012905 ATP-binding site [chemical binding]; other site 585035012906 CoA-binding site [chemical binding]; other site 585035012907 Mg2+-binding site [ion binding]; other site 585035012908 elongation factor Tu; Reviewed; Region: PRK00049 585035012909 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 585035012910 G1 box; other site 585035012911 GEF interaction site [polypeptide binding]; other site 585035012912 GTP/Mg2+ binding site [chemical binding]; other site 585035012913 Switch I region; other site 585035012914 G2 box; other site 585035012915 G3 box; other site 585035012916 Switch II region; other site 585035012917 G4 box; other site 585035012918 G5 box; other site 585035012919 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 585035012920 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 585035012921 Antibiotic Binding Site [chemical binding]; other site 585035012922 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 585035012923 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 585035012924 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 585035012925 putative homodimer interface [polypeptide binding]; other site 585035012926 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 585035012927 heterodimer interface [polypeptide binding]; other site 585035012928 homodimer interface [polypeptide binding]; other site 585035012929 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 585035012930 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 585035012931 23S rRNA interface [nucleotide binding]; other site 585035012932 L7/L12 interface [polypeptide binding]; other site 585035012933 putative thiostrepton binding site; other site 585035012934 L25 interface [polypeptide binding]; other site 585035012935 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 585035012936 mRNA/rRNA interface [nucleotide binding]; other site 585035012937 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 585035012938 23S rRNA interface [nucleotide binding]; other site 585035012939 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 585035012940 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 585035012941 core dimer interface [polypeptide binding]; other site 585035012942 peripheral dimer interface [polypeptide binding]; other site 585035012943 L10 interface [polypeptide binding]; other site 585035012944 L11 interface [polypeptide binding]; other site 585035012945 putative EF-Tu interaction site [polypeptide binding]; other site 585035012946 putative EF-G interaction site [polypeptide binding]; other site 585035012947 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 585035012948 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 585035012949 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 585035012950 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 585035012951 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 585035012952 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 585035012953 RPB3 interaction site [polypeptide binding]; other site 585035012954 RPB1 interaction site [polypeptide binding]; other site 585035012955 RPB11 interaction site [polypeptide binding]; other site 585035012956 RPB10 interaction site [polypeptide binding]; other site 585035012957 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 585035012958 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 585035012959 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 585035012960 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 585035012961 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 585035012962 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 585035012963 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 585035012964 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 585035012965 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 585035012966 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 585035012967 DNA binding site [nucleotide binding] 585035012968 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 585035012969 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 585035012970 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585035012971 FeS/SAM binding site; other site 585035012972 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 585035012973 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 585035012974 ThiS interaction site; other site 585035012975 putative active site [active] 585035012976 tetramer interface [polypeptide binding]; other site 585035012977 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 585035012978 thiS-thiF/thiG interaction site; other site 585035012979 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 585035012980 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 585035012981 ATP binding site [chemical binding]; other site 585035012982 substrate interface [chemical binding]; other site 585035012983 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 585035012984 thiamine phosphate binding site [chemical binding]; other site 585035012985 active site 585035012986 pyrophosphate binding site [ion binding]; other site 585035012987 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 585035012988 ThiC-associated domain; Region: ThiC-associated; pfam13667 585035012989 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 585035012990 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 585035012991 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 585035012992 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 585035012993 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 585035012994 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 585035012995 putative NADH binding site [chemical binding]; other site 585035012996 putative active site [active] 585035012997 nudix motif; other site 585035012998 putative metal binding site [ion binding]; other site 585035012999 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 585035013000 substrate binding site [chemical binding]; other site 585035013001 active site 585035013002 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 585035013003 Active_site [active] 585035013004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 585035013005 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 585035013006 IHF dimer interface [polypeptide binding]; other site 585035013007 IHF - DNA interface [nucleotide binding]; other site 585035013008 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 585035013009 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 585035013010 dimer interface [polypeptide binding]; other site 585035013011 sensor protein ZraS; Provisional; Region: PRK10364 585035013012 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585035013013 dimer interface [polypeptide binding]; other site 585035013014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035013015 ATP binding site [chemical binding]; other site 585035013016 Mg2+ binding site [ion binding]; other site 585035013017 G-X-G motif; other site 585035013018 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 585035013019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035013020 active site 585035013021 phosphorylation site [posttranslational modification] 585035013022 intermolecular recognition site; other site 585035013023 dimerization interface [polypeptide binding]; other site 585035013024 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035013025 Walker A motif; other site 585035013026 ATP binding site [chemical binding]; other site 585035013027 Walker B motif; other site 585035013028 arginine finger; other site 585035013029 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 585035013030 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 585035013031 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 585035013032 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 585035013033 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 585035013034 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 585035013035 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 585035013036 purine monophosphate binding site [chemical binding]; other site 585035013037 dimer interface [polypeptide binding]; other site 585035013038 putative catalytic residues [active] 585035013039 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 585035013040 hypothetical protein; Provisional; Region: PRK10039 585035013041 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 585035013042 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585035013043 Coenzyme A binding pocket [chemical binding]; other site 585035013044 homoserine O-succinyltransferase; Provisional; Region: PRK05368 585035013045 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 585035013046 proposed active site lysine [active] 585035013047 conserved cys residue [active] 585035013048 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 585035013049 malate synthase A; Region: malate_syn_A; TIGR01344 585035013050 active site 585035013051 isocitrate lyase; Provisional; Region: PRK15063 585035013052 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 585035013053 tetramer interface [polypeptide binding]; other site 585035013054 active site 585035013055 Mg2+/Mn2+ binding site [ion binding]; other site 585035013056 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 585035013057 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 585035013058 transcriptional repressor IclR; Provisional; Region: PRK11569 585035013059 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 585035013060 Bacterial transcriptional regulator; Region: IclR; pfam01614 585035013061 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 585035013062 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 585035013063 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 585035013064 substrate binding pocket [chemical binding]; other site 585035013065 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 585035013066 B12 binding site [chemical binding]; other site 585035013067 cobalt ligand [ion binding]; other site 585035013068 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 585035013069 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 585035013070 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 585035013071 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 585035013072 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 585035013073 active site pocket [active] 585035013074 oxyanion hole [active] 585035013075 catalytic triad [active] 585035013076 active site nucleophile [active] 585035013077 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 585035013078 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 585035013079 putative NAD(P) binding site [chemical binding]; other site 585035013080 catalytic Zn binding site [ion binding]; other site 585035013081 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 585035013082 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 585035013083 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 585035013084 active site 585035013085 phosphorylation site [posttranslational modification] 585035013086 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 585035013087 active pocket/dimerization site; other site 585035013088 active site 585035013089 phosphorylation site [posttranslational modification] 585035013090 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 585035013091 classical (c) SDRs; Region: SDR_c; cd05233 585035013092 NAD(P) binding site [chemical binding]; other site 585035013093 active site 585035013094 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 585035013095 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 585035013096 putative DNA binding site [nucleotide binding]; other site 585035013097 putative Zn2+ binding site [ion binding]; other site 585035013098 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 585035013099 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 585035013100 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 585035013101 RNA binding surface [nucleotide binding]; other site 585035013102 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 585035013103 probable active site [active] 585035013104 hypothetical protein; Provisional; Region: PRK10515 585035013105 aspartate kinase III; Validated; Region: PRK09084 585035013106 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 585035013107 nucleotide binding site [chemical binding]; other site 585035013108 substrate binding site [chemical binding]; other site 585035013109 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 585035013110 lysine allosteric regulatory site; other site 585035013111 dimer interface [polypeptide binding]; other site 585035013112 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 585035013113 dimer interface [polypeptide binding]; other site 585035013114 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 585035013115 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 585035013116 active site 585035013117 dimer interface [polypeptide binding]; other site 585035013118 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 585035013119 dimer interface [polypeptide binding]; other site 585035013120 active site 585035013121 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 585035013122 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 585035013123 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 585035013124 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 585035013125 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 585035013126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035013127 dimer interface [polypeptide binding]; other site 585035013128 conserved gate region; other site 585035013129 putative PBP binding loops; other site 585035013130 ABC-ATPase subunit interface; other site 585035013131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035013132 dimer interface [polypeptide binding]; other site 585035013133 conserved gate region; other site 585035013134 putative PBP binding loops; other site 585035013135 ABC-ATPase subunit interface; other site 585035013136 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 585035013137 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 585035013138 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 585035013139 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 585035013140 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 585035013141 Walker A/P-loop; other site 585035013142 ATP binding site [chemical binding]; other site 585035013143 Q-loop/lid; other site 585035013144 ABC transporter signature motif; other site 585035013145 Walker B; other site 585035013146 D-loop; other site 585035013147 H-loop/switch region; other site 585035013148 TOBE domain; Region: TOBE_2; pfam08402 585035013149 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 585035013150 trimer interface; other site 585035013151 sugar binding site [chemical binding]; other site 585035013152 maltose regulon periplasmic protein; Provisional; Region: PRK10564 585035013153 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 585035013154 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 585035013155 UbiA prenyltransferase family; Region: UbiA; pfam01040 585035013156 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 585035013157 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 585035013158 putative acyl-acceptor binding pocket; other site 585035013159 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 585035013160 LexA repressor; Validated; Region: PRK00215 585035013161 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 585035013162 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585035013163 Catalytic site [active] 585035013164 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 585035013165 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 585035013166 hypothetical protein; Provisional; Region: PRK10428 585035013167 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 585035013168 metal binding site 2 [ion binding]; metal-binding site 585035013169 putative DNA binding helix; other site 585035013170 metal binding site 1 [ion binding]; metal-binding site 585035013171 dimer interface [polypeptide binding]; other site 585035013172 structural Zn2+ binding site [ion binding]; other site 585035013173 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 585035013174 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 585035013175 FMN binding site [chemical binding]; other site 585035013176 active site 585035013177 catalytic residues [active] 585035013178 substrate binding site [chemical binding]; other site 585035013179 phage shock protein G; Reviewed; Region: pspG; PRK09459 585035013180 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 585035013181 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 585035013182 NADP binding site [chemical binding]; other site 585035013183 dimer interface [polypeptide binding]; other site 585035013184 L-aspartate oxidase; Provisional; Region: PRK06175 585035013185 FAD binding domain; Region: FAD_binding_2; pfam00890 585035013186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035013187 metabolite-proton symporter; Region: 2A0106; TIGR00883 585035013188 putative substrate translocation pore; other site 585035013189 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 585035013190 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585035013191 substrate binding site [chemical binding]; other site 585035013192 oxyanion hole (OAH) forming residues; other site 585035013193 trimer interface [polypeptide binding]; other site 585035013194 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 585035013195 Coenzyme A transferase; Region: CoA_trans; smart00882 585035013196 Coenzyme A transferase; Region: CoA_trans; cl17247 585035013197 Transcriptional regulators [Transcription]; Region: PurR; COG1609 585035013198 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585035013199 DNA binding site [nucleotide binding] 585035013200 domain linker motif; other site 585035013201 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 585035013202 putative dimerization interface [polypeptide binding]; other site 585035013203 putative ligand binding site [chemical binding]; other site 585035013204 replicative DNA helicase; Provisional; Region: PRK08006 585035013205 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 585035013206 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 585035013207 Walker A motif; other site 585035013208 ATP binding site [chemical binding]; other site 585035013209 Walker B motif; other site 585035013210 DNA binding loops [nucleotide binding] 585035013211 alanine racemase; Reviewed; Region: alr; PRK00053 585035013212 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 585035013213 active site 585035013214 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 585035013215 substrate binding site [chemical binding]; other site 585035013216 catalytic residues [active] 585035013217 dimer interface [polypeptide binding]; other site 585035013218 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 585035013219 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 585035013220 active site 585035013221 nucleotide binding site [chemical binding]; other site 585035013222 HIGH motif; other site 585035013223 KMSKS motif; other site 585035013224 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 585035013225 AAA domain; Region: AAA_28; pfam13521 585035013226 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 585035013227 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585035013228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035013229 homodimer interface [polypeptide binding]; other site 585035013230 catalytic residue [active] 585035013231 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 585035013232 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 585035013233 TPP-binding site [chemical binding]; other site 585035013234 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 585035013235 dimer interface [polypeptide binding]; other site 585035013236 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 585035013237 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 585035013238 E3 interaction surface; other site 585035013239 lipoyl attachment site [posttranslational modification]; other site 585035013240 e3 binding domain; Region: E3_binding; pfam02817 585035013241 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 585035013242 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 585035013243 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 585035013244 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 585035013245 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 585035013246 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 585035013247 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 585035013248 CoA-ligase; Region: Ligase_CoA; pfam00549 585035013249 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 585035013250 CoA binding domain; Region: CoA_binding; smart00881 585035013251 CoA-ligase; Region: Ligase_CoA; pfam00549 585035013252 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 585035013253 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 585035013254 transmembrane helices; other site 585035013255 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 585035013256 Evidence 2b : Function of strongly homologous gene; PubMedId : 3671068; Product type r : regulator 585035013257 Evidence 2b : Function of strongly homologous gene; PubMedId : 367106; Product type r : regulator 585035013258 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 585035013259 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585035013260 dimer interface [polypeptide binding]; other site 585035013261 phosphorylation site [posttranslational modification] 585035013262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035013263 ATP binding site [chemical binding]; other site 585035013264 Mg2+ binding site [ion binding]; other site 585035013265 G-X-G motif; other site 585035013266 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585035013267 active site 585035013268 motif I; other site 585035013269 motif II; other site 585035013270 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 585035013271 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 585035013272 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 585035013273 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 585035013274 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 585035013275 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 585035013276 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 585035013277 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 585035013278 dimer interface [polypeptide binding]; other site 585035013279 ssDNA binding site [nucleotide binding]; other site 585035013280 tetramer (dimer of dimers) interface [polypeptide binding]; other site 585035013281 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 585035013282 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 585035013283 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 585035013284 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 585035013285 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 585035013286 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035013287 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 585035013288 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 585035013289 DNA binding residues [nucleotide binding] 585035013290 dimer interface [polypeptide binding]; other site 585035013291 [2Fe-2S] cluster binding site [ion binding]; other site 585035013292 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 585035013293 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 585035013294 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 585035013295 Transcriptional regulator [Transcription]; Region: LysR; COG0583 585035013296 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035013297 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 585035013298 putative dimerization interface [polypeptide binding]; other site 585035013299 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 585035013300 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 585035013301 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 585035013302 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 585035013303 Na binding site [ion binding]; other site 585035013304 Predicted membrane protein [Function unknown]; Region: COG3162 585035013305 acetyl-CoA synthetase; Provisional; Region: PRK00174 585035013306 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 585035013307 active site 585035013308 CoA binding site [chemical binding]; other site 585035013309 acyl-activating enzyme (AAE) consensus motif; other site 585035013310 AMP binding site [chemical binding]; other site 585035013311 acetate binding site [chemical binding]; other site 585035013312 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 585035013313 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 585035013314 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 585035013315 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 585035013316 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 585035013317 heme lyase subunit NrfE; Provisional; Region: PRK10369 585035013318 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 585035013319 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 585035013320 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 585035013321 binding surface 585035013322 TPR motif; other site 585035013323 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 585035013324 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 585035013325 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 585035013326 Sel1-like repeats; Region: SEL1; smart00671 585035013327 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 585035013328 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585035013329 Walker A/P-loop; other site 585035013330 ATP binding site [chemical binding]; other site 585035013331 Q-loop/lid; other site 585035013332 ABC transporter signature motif; other site 585035013333 Walker B; other site 585035013334 D-loop; other site 585035013335 H-loop/switch region; other site 585035013336 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 585035013337 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585035013338 Walker A/P-loop; other site 585035013339 ATP binding site [chemical binding]; other site 585035013340 Q-loop/lid; other site 585035013341 ABC transporter signature motif; other site 585035013342 Walker B; other site 585035013343 D-loop; other site 585035013344 H-loop/switch region; other site 585035013345 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 585035013346 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 585035013347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035013348 dimer interface [polypeptide binding]; other site 585035013349 conserved gate region; other site 585035013350 ABC-ATPase subunit interface; other site 585035013351 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 585035013352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035013353 dimer interface [polypeptide binding]; other site 585035013354 conserved gate region; other site 585035013355 putative PBP binding loops; other site 585035013356 ABC-ATPase subunit interface; other site 585035013357 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 585035013358 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 585035013359 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 585035013360 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 585035013361 [4Fe-4S] binding site [ion binding]; other site 585035013362 molybdopterin cofactor binding site; other site 585035013363 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 585035013364 molybdopterin cofactor binding site; other site 585035013365 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 585035013366 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 585035013367 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 585035013368 multidrug resistance protein MdtN; Provisional; Region: PRK10476 585035013369 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585035013370 HlyD family secretion protein; Region: HlyD_3; pfam13437 585035013371 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 585035013372 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 585035013373 D-allose kinase; Provisional; Region: PRK09698 585035013374 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585035013375 nucleotide binding site [chemical binding]; other site 585035013376 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 585035013377 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 585035013378 substrate binding site [chemical binding]; other site 585035013379 hexamer interface [polypeptide binding]; other site 585035013380 metal binding site [ion binding]; metal-binding site 585035013381 Evidence 7 : Gene remnant; Product type t : transporter 585035013382 Evidence 7 : Gene remnant; Product type t : transporter 585035013383 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 585035013384 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585035013385 Walker A/P-loop; other site 585035013386 ATP binding site [chemical binding]; other site 585035013387 Q-loop/lid; other site 585035013388 ABC transporter signature motif; other site 585035013389 Walker B; other site 585035013390 D-loop; other site 585035013391 H-loop/switch region; other site 585035013392 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585035013393 D-allose transporter subunit; Provisional; Region: PRK09701 585035013394 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 585035013395 ligand binding site [chemical binding]; other site 585035013396 dimerization interface [polypeptide binding]; other site 585035013397 zinc binding site [ion binding]; other site 585035013398 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 585035013399 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 585035013400 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 585035013401 putative active site [active] 585035013402 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 585035013403 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 585035013404 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585035013405 Coenzyme A binding pocket [chemical binding]; other site 585035013406 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 585035013407 AAA domain; Region: AAA_18; pfam13238 585035013408 active site 585035013409 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 585035013410 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 585035013411 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 585035013412 active site 585035013413 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 585035013414 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 585035013415 Walker A/P-loop; other site 585035013416 ATP binding site [chemical binding]; other site 585035013417 Q-loop/lid; other site 585035013418 ABC transporter signature motif; other site 585035013419 Walker B; other site 585035013420 D-loop; other site 585035013421 H-loop/switch region; other site 585035013422 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 585035013423 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 585035013424 Walker A/P-loop; other site 585035013425 ATP binding site [chemical binding]; other site 585035013426 Q-loop/lid; other site 585035013427 ABC transporter signature motif; other site 585035013428 Walker B; other site 585035013429 D-loop; other site 585035013430 H-loop/switch region; other site 585035013431 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 585035013432 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 585035013433 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 585035013434 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 585035013435 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 585035013436 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 585035013437 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585035013438 DNA-binding site [nucleotide binding]; DNA binding site 585035013439 UTRA domain; Region: UTRA; pfam07702 585035013440 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 585035013441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 585035013442 dimer interface [polypeptide binding]; other site 585035013443 conserved gate region; other site 585035013444 putative PBP binding loops; other site 585035013445 ABC-ATPase subunit interface; other site 585035013446 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 585035013447 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 585035013448 substrate binding pocket [chemical binding]; other site 585035013449 membrane-bound complex binding site; other site 585035013450 hinge residues; other site 585035013451 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 585035013452 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 585035013453 Walker A/P-loop; other site 585035013454 ATP binding site [chemical binding]; other site 585035013455 Q-loop/lid; other site 585035013456 ABC transporter signature motif; other site 585035013457 Walker B; other site 585035013458 D-loop; other site 585035013459 H-loop/switch region; other site 585035013460 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 585035013461 dimer interface [polypeptide binding]; other site 585035013462 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 585035013463 hypothetical protein; Provisional; Region: PRK10220 585035013464 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 585035013465 PhnA protein; Region: PhnA; pfam03831 585035013466 hypothetical protein; Provisional; Region: PRK09866 585035013467 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 585035013468 G1 box; other site 585035013469 GTP/Mg2+ binding site [chemical binding]; other site 585035013470 G2 box; other site 585035013471 Switch I region; other site 585035013472 G3 box; other site 585035013473 Switch II region; other site 585035013474 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 585035013475 G2 box; other site 585035013476 Switch I region; other site 585035013477 G3 box; other site 585035013478 Switch II region; other site 585035013479 G4 box; other site 585035013480 G5 box; other site 585035013481 YjcZ-like protein; Region: YjcZ; pfam13990 585035013482 proline/glycine betaine transporter; Provisional; Region: PRK10642 585035013483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035013484 putative substrate translocation pore; other site 585035013485 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 585035013486 sensor protein BasS/PmrB; Provisional; Region: PRK10755 585035013487 HAMP domain; Region: HAMP; pfam00672 585035013488 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585035013489 dimer interface [polypeptide binding]; other site 585035013490 phosphorylation site [posttranslational modification] 585035013491 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035013492 ATP binding site [chemical binding]; other site 585035013493 Mg2+ binding site [ion binding]; other site 585035013494 G-X-G motif; other site 585035013495 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 585035013496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035013497 active site 585035013498 phosphorylation site [posttranslational modification] 585035013499 intermolecular recognition site; other site 585035013500 dimerization interface [polypeptide binding]; other site 585035013501 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585035013502 DNA binding site [nucleotide binding] 585035013503 putative metal dependent hydrolase; Provisional; Region: PRK11598 585035013504 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 585035013505 Sulfatase; Region: Sulfatase; pfam00884 585035013506 arginine:agmatin antiporter; Provisional; Region: PRK10644 585035013507 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585035013508 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035013509 arginine decarboxylase; Provisional; Region: PRK15029 585035013510 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 585035013511 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 585035013512 homodimer interface [polypeptide binding]; other site 585035013513 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035013514 catalytic residue [active] 585035013515 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 585035013516 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 585035013517 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035013518 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035013519 alpha-galactosidase; Provisional; Region: PRK15076 585035013520 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 585035013521 NAD binding site [chemical binding]; other site 585035013522 sugar binding site [chemical binding]; other site 585035013523 divalent metal binding site [ion binding]; other site 585035013524 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 585035013525 dimer interface [polypeptide binding]; other site 585035013526 hypothetical protein; Provisional; Region: PRK09867 585035013527 fumarate hydratase; Provisional; Region: PRK15389 585035013528 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 585035013529 Fumarase C-terminus; Region: Fumerase_C; pfam05683 585035013530 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 585035013531 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 585035013532 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 585035013533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035013534 active site 585035013535 phosphorylation site [posttranslational modification] 585035013536 intermolecular recognition site; other site 585035013537 dimerization interface [polypeptide binding]; other site 585035013538 Transcriptional regulator; Region: CitT; pfam12431 585035013539 sensory histidine kinase DcuS; Provisional; Region: PRK11086 585035013540 PAS domain; Region: PAS; smart00091 585035013541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035013542 ATP binding site [chemical binding]; other site 585035013543 Mg2+ binding site [ion binding]; other site 585035013544 G-X-G motif; other site 585035013545 Uncharacterized conserved protein [Function unknown]; Region: COG3592 585035013546 Predicted acetyltransferase [General function prediction only]; Region: COG2388 585035013547 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 585035013548 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 585035013549 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 585035013550 dimer interface [polypeptide binding]; other site 585035013551 putative anticodon binding site; other site 585035013552 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 585035013553 motif 1; other site 585035013554 active site 585035013555 motif 2; other site 585035013556 motif 3; other site 585035013557 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 585035013558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035013559 putative substrate translocation pore; other site 585035013560 POT family; Region: PTR2; pfam00854 585035013561 lysine decarboxylase CadA; Provisional; Region: PRK15400 585035013562 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 585035013563 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 585035013564 homodimer interface [polypeptide binding]; other site 585035013565 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035013566 catalytic residue [active] 585035013567 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 585035013568 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 585035013569 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 585035013570 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585035013571 DNA binding site [nucleotide binding] 585035013572 Methyltransferase domain; Region: Methyltransf_27; pfam13708 585035013573 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 585035013574 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 585035013575 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 585035013576 Protein of unknown function (DUF987); Region: DUF987; pfam06174 585035013577 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 585035013578 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 585035013579 MPN+ (JAMM) motif; other site 585035013580 Zinc-binding site [ion binding]; other site 585035013581 Antirestriction protein; Region: Antirestrict; pfam03230 585035013582 Domain of unknown function (DUF932); Region: DUF932; pfam06067 585035013583 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 585035013584 HTH domain; Region: HTH_11; cl17392 585035013585 WYL domain; Region: WYL; pfam13280 585035013586 Predicted GTPase [General function prediction only]; Region: COG3596 585035013587 YfjP GTPase; Region: YfjP; cd11383 585035013588 G1 box; other site 585035013589 GTP/Mg2+ binding site [chemical binding]; other site 585035013590 Switch I region; other site 585035013591 G2 box; other site 585035013592 Switch II region; other site 585035013593 G3 box; other site 585035013594 G4 box; other site 585035013595 G5 box; other site 585035013596 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 585035013597 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 585035013598 Evidence 7 : Gene remnant; Product type r : regulator 585035013599 Protein export membrane protein; Region: SecD_SecF; cl14618 585035013600 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585035013601 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 585035013602 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator 585035013603 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 585035013604 Hexamer interface [polypeptide binding]; other site 585035013605 Hexagonal pore residue; other site 585035013606 S-adenosylmethionine synthetase; Validated; Region: PRK05250 585035013607 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 585035013608 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 585035013609 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 585035013610 Response regulator receiver domain; Region: Response_reg; pfam00072 585035013611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035013612 active site 585035013613 phosphorylation site [posttranslational modification] 585035013614 intermolecular recognition site; other site 585035013615 dimerization interface [polypeptide binding]; other site 585035013616 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035013617 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 585035013618 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035013619 Sensory domain found in PocR; Region: PocR; pfam10114 585035013620 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 585035013621 Histidine kinase; Region: His_kinase; pfam06580 585035013622 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035013623 ATP binding site [chemical binding]; other site 585035013624 Mg2+ binding site [ion binding]; other site 585035013625 G-X-G motif; other site 585035013626 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 585035013627 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 585035013628 active site 585035013629 nucleic acid binding site [nucleotide binding]; other site 585035013630 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 585035013631 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 585035013632 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 585035013633 putative NTP binding site [chemical binding]; other site 585035013634 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 585035013635 4Fe-4S binding domain; Region: Fer4; cl02805 585035013636 4Fe-4S binding domain; Region: Fer4_6; pfam12837 585035013637 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585035013638 FeS/SAM binding site; other site 585035013639 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 585035013640 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 585035013641 dimer interface [polypeptide binding]; other site 585035013642 active site 585035013643 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 585035013644 intracellular protease, PfpI family; Region: PfpI; TIGR01382 585035013645 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 585035013646 conserved cys residue [active] 585035013647 Bacterial Micro-Compartment (BMC)-like domain 2; Region: BMC_like_2; cd07055 585035013648 putative hexamer interface [polypeptide binding]; other site 585035013649 putative hexagonal pore; other site 585035013650 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 585035013651 putative catalytic cysteine [active] 585035013652 propanediol utilization protein PduB; Provisional; Region: PRK15415 585035013653 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 585035013654 putative hexamer interface [polypeptide binding]; other site 585035013655 putative hexagonal pore; other site 585035013656 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 585035013657 putative hexamer interface [polypeptide binding]; other site 585035013658 putative hexagonal pore; other site 585035013659 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 585035013660 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 585035013661 Hexamer interface [polypeptide binding]; other site 585035013662 Putative hexagonal pore residue; other site 585035013663 propionate/acetate kinase; Provisional; Region: PRK12379 585035013664 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 585035013665 Domain of unknown function (DUF336); Region: DUF336; pfam03928 585035013666 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 585035013667 Hexamer/Pentamer interface [polypeptide binding]; other site 585035013668 central pore; other site 585035013669 Flavoprotein; Region: Flavoprotein; cl08021 585035013670 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 585035013671 ethanolamine utilization protein EutJ family protein; Region: EutJ; TIGR02529 585035013672 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 585035013673 nucleotide binding site [chemical binding]; other site 585035013674 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 585035013675 Propanediol utilisation protein PduL; Region: PduL; pfam06130 585035013676 Propanediol utilisation protein PduL; Region: PduL; pfam06130 585035013677 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 585035013678 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 585035013679 putative active site [active] 585035013680 metal binding site [ion binding]; metal-binding site 585035013681 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 585035013682 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 585035013683 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 585035013684 ImpA domain protein; Region: DUF3702; pfam12486 585035013685 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 585035013686 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 585035013687 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 585035013688 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 585035013689 active site 585035013690 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 585035013691 active site 585035013692 NTP binding site [chemical binding]; other site 585035013693 metal binding triad [ion binding]; metal-binding site 585035013694 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme 585035013695 putative transposase OrfB; Reviewed; Region: PHA02517 585035013696 HTH-like domain; Region: HTH_21; pfam13276 585035013697 Integrase core domain; Region: rve; pfam00665 585035013698 Integrase core domain; Region: rve_2; pfam13333 585035013699 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585035013700 Transposase; Region: HTH_Tnp_1; pfam01527 585035013701 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 585035013702 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 585035013703 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585035013704 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585035013705 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585035013706 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 585035013707 arginine decarboxylase; Provisional; Region: PRK15029 585035013708 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 585035013709 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 585035013710 homodimer interface [polypeptide binding]; other site 585035013711 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035013712 catalytic residue [active] 585035013713 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 585035013714 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 585035013715 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585035013716 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585035013717 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585035013718 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 585035013719 MarR family; Region: MarR_2; cl17246 585035013720 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 585035013721 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme 585035013722 Evidence 7 : Gene remnant; Product type pe : enzyme 585035013723 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 585035013724 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585035013725 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585035013726 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585035013727 DNA primase; Validated; Region: dnaG; PRK05667 585035013728 integrase; Provisional; Region: PRK09692 585035013729 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585035013730 active site 585035013731 Int/Topo IB signature motif; other site 585035013732 putative transcriptional regulator; Provisional; Region: PRK11640 585035013733 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585035013734 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 585035013735 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 585035013736 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 585035013737 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 585035013738 DsbD alpha interface [polypeptide binding]; other site 585035013739 catalytic residues [active] 585035013740 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 585035013741 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 585035013742 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 585035013743 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 585035013744 Aspartase; Region: Aspartase; cd01357 585035013745 active sites [active] 585035013746 tetramer interface [polypeptide binding]; other site 585035013747 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 585035013748 putative transporter; Provisional; Region: PRK11021 585035013749 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 585035013750 oligomerisation interface [polypeptide binding]; other site 585035013751 mobile loop; other site 585035013752 roof hairpin; other site 585035013753 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 585035013754 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 585035013755 ring oligomerisation interface [polypeptide binding]; other site 585035013756 ATP/Mg binding site [chemical binding]; other site 585035013757 stacking interactions; other site 585035013758 hinge regions; other site 585035013759 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 585035013760 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 585035013761 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585035013762 FeS/SAM binding site; other site 585035013763 elongation factor P; Validated; Region: PRK00529 585035013764 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 585035013765 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 585035013766 RNA binding site [nucleotide binding]; other site 585035013767 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 585035013768 RNA binding site [nucleotide binding]; other site 585035013769 entericidin A; Provisional; Region: PRK09810 585035013770 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 585035013771 multidrug efflux system protein; Provisional; Region: PRK11431 585035013772 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 585035013773 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 585035013774 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 585035013775 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 585035013776 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 585035013777 Iron-sulfur protein interface; other site 585035013778 proximal quinone binding site [chemical binding]; other site 585035013779 C-subunit interface; other site 585035013780 distal quinone binding site; other site 585035013781 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 585035013782 D-subunit interface [polypeptide binding]; other site 585035013783 Iron-sulfur protein interface; other site 585035013784 proximal quinone binding site [chemical binding]; other site 585035013785 distal quinone binding site [chemical binding]; other site 585035013786 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 585035013787 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 585035013788 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 585035013789 L-aspartate oxidase; Provisional; Region: PRK06175 585035013790 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 585035013791 poxB regulator PoxA; Provisional; Region: PRK09350 585035013792 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 585035013793 motif 1; other site 585035013794 dimer interface [polypeptide binding]; other site 585035013795 active site 585035013796 motif 2; other site 585035013797 motif 3; other site 585035013798 inner membrane transporter YjeM; Provisional; Region: PRK15238 585035013799 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 585035013800 putative mechanosensitive channel protein; Provisional; Region: PRK10929 585035013801 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 585035013802 DNA-binding site [nucleotide binding]; DNA binding site 585035013803 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 585035013804 Mechanosensitive ion channel; Region: MS_channel; pfam00924 585035013805 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 585035013806 GTPase RsgA; Reviewed; Region: PRK12288 585035013807 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 585035013808 RNA binding site [nucleotide binding]; other site 585035013809 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 585035013810 GTPase/Zn-binding domain interface [polypeptide binding]; other site 585035013811 GTP/Mg2+ binding site [chemical binding]; other site 585035013812 G4 box; other site 585035013813 G5 box; other site 585035013814 G1 box; other site 585035013815 Switch I region; other site 585035013816 G2 box; other site 585035013817 G3 box; other site 585035013818 Switch II region; other site 585035013819 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 585035013820 catalytic site [active] 585035013821 putative active site [active] 585035013822 putative substrate binding site [chemical binding]; other site 585035013823 dimer interface [polypeptide binding]; other site 585035013824 epoxyqueuosine reductase; Region: TIGR00276 585035013825 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 585035013826 putative carbohydrate kinase; Provisional; Region: PRK10565 585035013827 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 585035013828 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 585035013829 putative substrate binding site [chemical binding]; other site 585035013830 putative ATP binding site [chemical binding]; other site 585035013831 ADP-binding protein; Provisional; Region: PRK10646 585035013832 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 585035013833 AMIN domain; Region: AMIN; pfam11741 585035013834 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 585035013835 active site 585035013836 metal binding site [ion binding]; metal-binding site 585035013837 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 585035013838 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035013839 ATP binding site [chemical binding]; other site 585035013840 Mg2+ binding site [ion binding]; other site 585035013841 G-X-G motif; other site 585035013842 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 585035013843 ATP binding site [chemical binding]; other site 585035013844 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 585035013845 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 585035013846 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 585035013847 bacterial Hfq-like; Region: Hfq; cd01716 585035013848 hexamer interface [polypeptide binding]; other site 585035013849 Sm1 motif; other site 585035013850 RNA binding site [nucleotide binding]; other site 585035013851 Sm2 motif; other site 585035013852 GTPase HflX; Provisional; Region: PRK11058 585035013853 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 585035013854 HflX GTPase family; Region: HflX; cd01878 585035013855 G1 box; other site 585035013856 GTP/Mg2+ binding site [chemical binding]; other site 585035013857 Switch I region; other site 585035013858 G2 box; other site 585035013859 G3 box; other site 585035013860 Switch II region; other site 585035013861 G4 box; other site 585035013862 G5 box; other site 585035013863 FtsH protease regulator HflK; Provisional; Region: PRK10930 585035013864 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 585035013865 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 585035013866 FtsH protease regulator HflC; Provisional; Region: PRK11029 585035013867 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 585035013868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 585035013869 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 585035013870 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 585035013871 GDP-binding site [chemical binding]; other site 585035013872 ACT binding site; other site 585035013873 IMP binding site; other site 585035013874 Predicted transcriptional regulator [Transcription]; Region: COG1959 585035013875 transcriptional repressor NsrR; Provisional; Region: PRK11014 585035013876 exoribonuclease R; Provisional; Region: PRK11642 585035013877 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 585035013878 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 585035013879 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 585035013880 RNB domain; Region: RNB; pfam00773 585035013881 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 585035013882 RNA binding site [nucleotide binding]; other site 585035013883 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 585035013884 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 585035013885 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 585035013886 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 585035013887 PspA/IM30 family; Region: PspA_IM30; pfam04012 585035013888 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 585035013889 Predicted membrane protein [Function unknown]; Region: COG3766 585035013890 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 585035013891 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 585035013892 Predicted integral membrane protein [Function unknown]; Region: COG5463 585035013893 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 585035013894 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 585035013895 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 585035013896 FAD binding site [chemical binding]; other site 585035013897 substrate binding site [chemical binding]; other site 585035013898 catalytic residues [active] 585035013899 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585035013900 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 585035013901 esterase; Provisional; Region: PRK10566 585035013902 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 585035013903 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 585035013904 transcriptional repressor UlaR; Provisional; Region: PRK13509 585035013905 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585035013906 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585035013907 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 585035013908 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 585035013909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 585035013910 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 585035013911 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 585035013912 active site 585035013913 P-loop; other site 585035013914 phosphorylation site [posttranslational modification] 585035013915 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585035013916 active site 585035013917 phosphorylation site [posttranslational modification] 585035013918 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 585035013919 active site 585035013920 dimer interface [polypeptide binding]; other site 585035013921 magnesium binding site [ion binding]; other site 585035013922 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 585035013923 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 585035013924 AP (apurinic/apyrimidinic) site pocket; other site 585035013925 DNA interaction; other site 585035013926 Metal-binding active site; metal-binding site 585035013927 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 585035013928 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 585035013929 intersubunit interface [polypeptide binding]; other site 585035013930 active site 585035013931 Zn2+ binding site [ion binding]; other site 585035013932 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 585035013933 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 585035013934 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 585035013935 dimer interface [polypeptide binding]; other site 585035013936 ssDNA binding site [nucleotide binding]; other site 585035013937 tetramer (dimer of dimers) interface [polypeptide binding]; other site 585035013938 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 585035013939 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 585035013940 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 585035013941 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 585035013942 Helix-turn-helix domain; Region: HTH_31; pfam13560 585035013943 sequence-specific DNA binding site [nucleotide binding]; other site 585035013944 salt bridge; other site 585035013945 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 585035013946 HipA-like N-terminal domain; Region: HipA_N; pfam07805 585035013947 HipA-like C-terminal domain; Region: HipA_C; pfam07804 585035013948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035013949 D-galactonate transporter; Region: 2A0114; TIGR00893 585035013950 putative substrate translocation pore; other site 585035013951 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme 585035013952 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme 585035013953 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 585035013954 Coenzyme A transferase; Region: CoA_trans; smart00882 585035013955 Coenzyme A transferase; Region: CoA_trans; cl17247 585035013956 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 585035013957 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 585035013958 substrate binding site [chemical binding]; other site 585035013959 oxyanion hole (OAH) forming residues; other site 585035013960 trimer interface [polypeptide binding]; other site 585035013961 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 585035013962 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 585035013963 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337 585035013964 putative NAD(P) binding site [chemical binding]; other site 585035013965 active site 585035013966 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 585035013967 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585035013968 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 585035013969 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 585035013970 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 585035013971 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 585035013972 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 585035013973 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 585035013974 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 585035013975 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 585035013976 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 585035013977 Hemerythrin-like domain; Region: Hr-like; cd12108 585035013978 Fe binding site [ion binding]; other site 585035013979 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 585035013980 EamA-like transporter family; Region: EamA; pfam00892 585035013981 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 585035013982 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 585035013983 NADP binding site [chemical binding]; other site 585035013984 Predicted transcriptional regulators [Transcription]; Region: COG1733 585035013985 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 585035013986 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 585035013987 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 585035013988 active site 585035013989 metal binding site [ion binding]; metal-binding site 585035013990 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 585035013991 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 585035013992 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 585035013993 active site 585035013994 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 585035013995 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 585035013996 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 585035013997 Domain of unknown function DUF21; Region: DUF21; pfam01595 585035013998 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 585035013999 Transporter associated domain; Region: CorC_HlyC; smart01091 585035014000 methionine sulfoxide reductase A; Provisional; Region: PRK00058 585035014001 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 585035014002 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 585035014003 Surface antigen; Region: Bac_surface_Ag; pfam01103 585035014004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 585035014005 Family of unknown function (DUF490); Region: DUF490; pfam04357 585035014006 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 585035014007 putative active site pocket [active] 585035014008 dimerization interface [polypeptide binding]; other site 585035014009 putative catalytic residue [active] 585035014010 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 585035014011 dimer interface [polypeptide binding]; other site 585035014012 substrate binding site [chemical binding]; other site 585035014013 metal binding sites [ion binding]; metal-binding site 585035014014 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 585035014015 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 585035014016 putative ligand binding site [chemical binding]; other site 585035014017 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 585035014018 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 585035014019 Walker A/P-loop; other site 585035014020 ATP binding site [chemical binding]; other site 585035014021 Q-loop/lid; other site 585035014022 ABC transporter signature motif; other site 585035014023 Walker B; other site 585035014024 D-loop; other site 585035014025 H-loop/switch region; other site 585035014026 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 585035014027 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585035014028 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585035014029 TM-ABC transporter signature motif; other site 585035014030 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 585035014031 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 585035014032 TM-ABC transporter signature motif; other site 585035014033 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 585035014034 AMP binding site [chemical binding]; other site 585035014035 metal binding site [ion binding]; metal-binding site 585035014036 active site 585035014037 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 585035014038 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 585035014039 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 585035014040 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 585035014041 hypothetical protein; Provisional; Region: PRK05255 585035014042 peptidase PmbA; Provisional; Region: PRK11040 585035014043 cytochrome b562; Provisional; Region: PRK15058 585035014044 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 585035014045 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585035014046 FeS/SAM binding site; other site 585035014047 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 585035014048 ATP cone domain; Region: ATP-cone; pfam03477 585035014049 Class III ribonucleotide reductase; Region: RNR_III; cd01675 585035014050 effector binding site; other site 585035014051 active site 585035014052 Zn binding site [ion binding]; other site 585035014053 glycine loop; other site 585035014054 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 585035014055 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 585035014056 Ca binding site [ion binding]; other site 585035014057 active site 585035014058 catalytic site [active] 585035014059 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 585035014060 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 585035014061 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 585035014062 active site turn [active] 585035014063 phosphorylation site [posttranslational modification] 585035014064 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 585035014065 trehalose repressor; Provisional; Region: treR; PRK09492 585035014066 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 585035014067 DNA binding site [nucleotide binding] 585035014068 domain linker motif; other site 585035014069 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 585035014070 dimerization interface [polypeptide binding]; other site 585035014071 ligand binding site [chemical binding]; other site 585035014072 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 585035014073 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 585035014074 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 585035014075 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 585035014076 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585035014077 motif II; other site 585035014078 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 585035014079 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 585035014080 homotrimer interaction site [polypeptide binding]; other site 585035014081 putative active site [active] 585035014082 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 585035014083 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 585035014084 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 585035014085 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 585035014086 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 585035014087 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 585035014088 PyrBI operon leader peptide; Region: PyrBI_leader; pfam08052 585035014089 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 585035014090 homotrimer interaction site [polypeptide binding]; other site 585035014091 putative active site [active] 585035014092 oxidoreductase; Provisional; Region: PRK12742 585035014093 classical (c) SDRs; Region: SDR_c; cd05233 585035014094 NAD(P) binding site [chemical binding]; other site 585035014095 active site 585035014096 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 585035014097 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 585035014098 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 585035014099 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 585035014100 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 585035014101 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 585035014102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 585035014103 RNase E inhibitor protein; Provisional; Region: PRK11191 585035014104 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 585035014105 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585035014106 Coenzyme A binding pocket [chemical binding]; other site 585035014107 Predicted membrane protein [Function unknown]; Region: COG4269 585035014108 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 585035014109 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 585035014110 HIGH motif; other site 585035014111 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 585035014112 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 585035014113 active site 585035014114 KMSKS motif; other site 585035014115 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 585035014116 tRNA binding surface [nucleotide binding]; other site 585035014117 anticodon binding site; other site 585035014118 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 585035014119 DNA polymerase III subunit chi; Validated; Region: PRK05728 585035014120 multifunctional aminopeptidase A; Provisional; Region: PRK00913 585035014121 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 585035014122 interface (dimer of trimers) [polypeptide binding]; other site 585035014123 Substrate-binding/catalytic site; other site 585035014124 Zn-binding sites [ion binding]; other site 585035014125 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 585035014126 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 585035014127 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 585035014128 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 585035014129 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 585035014130 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 585035014131 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 585035014132 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 585035014133 putative NAD(P) binding site [chemical binding]; other site 585035014134 putative substrate binding site [chemical binding]; other site 585035014135 catalytic Zn binding site [ion binding]; other site 585035014136 structural Zn binding site [ion binding]; other site 585035014137 dimer interface [polypeptide binding]; other site 585035014138 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585035014139 Transposase; Region: HTH_Tnp_1; pfam01527 585035014140 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 585035014141 Helix-turn-helix domain; Region: HTH_38; pfam13936 585035014142 Homeodomain-like domain; Region: HTH_32; pfam13565 585035014143 Integrase core domain; Region: rve; pfam00665 585035014144 HTH-like domain; Region: HTH_21; pfam13276 585035014145 Integrase core domain; Region: rve; pfam00665 585035014146 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 585035014147 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 585035014148 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 585035014149 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 585035014150 Walker A/P-loop; other site 585035014151 ATP binding site [chemical binding]; other site 585035014152 Q-loop/lid; other site 585035014153 ABC transporter signature motif; other site 585035014154 Walker B; other site 585035014155 D-loop; other site 585035014156 H-loop/switch region; other site 585035014157 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 585035014158 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585035014159 ABC-ATPase subunit interface; other site 585035014160 dimer interface [polypeptide binding]; other site 585035014161 putative PBP binding regions; other site 585035014162 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 585035014163 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585035014164 dimer interface [polypeptide binding]; other site 585035014165 ABC-ATPase subunit interface; other site 585035014166 putative PBP binding regions; other site 585035014167 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 585035014168 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 585035014169 siderophore binding site; other site 585035014170 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 585035014171 Secretin and TonB N terminus short domain; Region: STN; smart00965 585035014172 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585035014173 N-terminal plug; other site 585035014174 ligand-binding site [chemical binding]; other site 585035014175 fec operon regulator FecR; Reviewed; Region: PRK09774 585035014176 FecR protein; Region: FecR; pfam04773 585035014177 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 585035014178 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 585035014179 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585035014180 DNA binding residues [nucleotide binding] 585035014181 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585035014182 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585035014183 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585035014184 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 585035014185 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 585035014186 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme 585035014187 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 585035014188 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme 585035014189 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme 585035014190 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme 585035014191 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 585035014192 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 585035014193 Transposase; Region: HTH_Tnp_1; pfam01527 585035014194 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585035014195 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 585035014196 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 585035014197 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 585035014198 Haemolysin expression modulating protein; Region: HHA; pfam05321 585035014199 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 585035014200 Predicted GTPase [General function prediction only]; Region: COG3596 585035014201 YfjP GTPase; Region: YfjP; cd11383 585035014202 G1 box; other site 585035014203 GTP/Mg2+ binding site [chemical binding]; other site 585035014204 Switch I region; other site 585035014205 G2 box; other site 585035014206 Switch II region; other site 585035014207 G3 box; other site 585035014208 G4 box; other site 585035014209 G5 box; other site 585035014210 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 585035014211 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 585035014212 hypothetical protein; Provisional; Region: PRK09945 585035014213 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 585035014214 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 585035014215 Autotransporter beta-domain; Region: Autotransporter; smart00869 585035014216 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 585035014217 Domain of unknown function (DUF932); Region: DUF932; pfam06067 585035014218 Antirestriction protein; Region: Antirestrict; pfam03230 585035014219 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 585035014220 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 585035014221 MPN+ (JAMM) motif; other site 585035014222 Zinc-binding site [ion binding]; other site 585035014223 Protein of unknown function (DUF987); Region: DUF987; pfam06174 585035014224 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 585035014225 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 585035014226 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035014227 Walker A motif; other site 585035014228 ATP binding site [chemical binding]; other site 585035014229 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585035014230 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 585035014231 DNA binding residues [nucleotide binding] 585035014232 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 585035014233 Integrase core domain; Region: rve; pfam00665 585035014234 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 585035014235 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 585035014236 Phosphotransferase enzyme family; Region: APH; pfam01636 585035014237 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 585035014238 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 585035014239 L-fuculose phosphate aldolase; Provisional; Region: PRK08087 585035014240 intersubunit interface [polypeptide binding]; other site 585035014241 active site 585035014242 Zn2+ binding site [ion binding]; other site 585035014243 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 585035014244 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 585035014245 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585035014246 DNA binding residues [nucleotide binding] 585035014247 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 585035014248 gluconate transporter; Region: gntP; TIGR00791 585035014249 fructuronate transporter; Provisional; Region: PRK10034; cl15264 585035014250 putative dehydratase; Provisional; Region: PRK08211 585035014251 Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Region: IlvD; COG0129 585035014252 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 585035014253 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 585035014254 inhibitor site; inhibition site 585035014255 active site 585035014256 dimer interface [polypeptide binding]; other site 585035014257 catalytic residue [active] 585035014258 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 585035014259 Transcriptional regulator [Transcription]; Region: IclR; COG1414 585035014260 Bacterial transcriptional regulator; Region: IclR; pfam01614 585035014261 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 585035014262 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 585035014263 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 585035014264 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 585035014265 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 585035014266 substrate binding site [chemical binding]; other site 585035014267 hexamer interface [polypeptide binding]; other site 585035014268 metal binding site [ion binding]; metal-binding site 585035014269 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 585035014270 active site 585035014271 phosphorylation site [posttranslational modification] 585035014272 membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259 585035014273 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 585035014274 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 585035014275 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 585035014276 active site 585035014277 P-loop; other site 585035014278 phosphorylation site [posttranslational modification] 585035014279 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 585035014280 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 585035014281 oligomer interface [polypeptide binding]; other site 585035014282 active site 585035014283 metal binding site [ion binding]; metal-binding site 585035014284 Methyltransferase domain; Region: Methyltransf_31; pfam13847 585035014285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035014286 S-adenosylmethionine binding site [chemical binding]; other site 585035014287 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 585035014288 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585035014289 Coenzyme A binding pocket [chemical binding]; other site 585035014290 hypothetical protein; Provisional; Region: PRK13687 585035014291 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 585035014292 Evidence 7 : Gene remnant; Product type pe : enzyme 585035014293 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 585035014294 AAA domain; Region: AAA_12; pfam13087 585035014295 C-terminal domain of Escherichia coli uncharacterized protein yjhR and similar proteins; Region: PLDc_yjhR_C_like; cd09118 585035014296 putative active site [active] 585035014297 catalytic site [active] 585035014298 Domain of unknown function (DUF303); Region: DUF303; pfam03629 585035014299 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 585035014300 Kelch motif; Region: Kelch_1; pfam01344 585035014301 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 585035014302 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 585035014303 Int/Topo IB signature motif; other site 585035014304 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 585035014305 Int/Topo IB signature motif; other site 585035014306 Fimbrial protein; Region: Fimbrial; cl01416 585035014307 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585035014308 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 585035014309 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 585035014310 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 585035014311 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 585035014312 PapC N-terminal domain; Region: PapC_N; pfam13954 585035014313 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 585035014314 PapC C-terminal domain; Region: PapC_C; pfam13953 585035014315 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585035014316 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 585035014317 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 585035014318 mannosyl binding site [chemical binding]; other site 585035014319 Fimbrial protein; Region: Fimbrial; pfam00419 585035014320 fructuronate transporter; Provisional; Region: PRK10034 585035014321 gluconate transporter; Region: gntP; TIGR00791 585035014322 mannonate dehydratase; Region: uxuA; TIGR00695 585035014323 mannonate dehydratase; Provisional; Region: PRK03906 585035014324 D-mannonate oxidoreductase; Provisional; Region: PRK15037 585035014325 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 585035014326 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 585035014327 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 585035014328 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585035014329 DNA-binding site [nucleotide binding]; DNA binding site 585035014330 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585035014331 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 585035014332 Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Region: GlyA; COG0112 585035014333 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 585035014334 cell density-dependent motility repressor; Provisional; Region: PRK10082 585035014335 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 585035014336 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 585035014337 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 585035014338 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 585035014339 dimer interface [polypeptide binding]; other site 585035014340 active site 585035014341 hypothetical protein; Provisional; Region: PRK10519 585035014342 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 585035014343 Nucleoside recognition; Region: Gate; pfam07670 585035014344 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 585035014345 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 585035014346 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 585035014347 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 585035014348 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 585035014349 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 585035014350 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 585035014351 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 585035014352 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 585035014353 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 585035014354 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 585035014355 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585035014356 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 585035014357 SdiA-regulated; Region: SdiA-regulated; pfam06977 585035014358 SdiA-regulated; Region: SdiA-regulated; cd09971 585035014359 putative active site [active] 585035014360 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 585035014361 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 585035014362 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 585035014363 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 585035014364 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 585035014365 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 585035014366 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 585035014367 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 585035014368 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 585035014369 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 585035014370 Predicted membrane protein [Function unknown]; Region: COG2733 585035014371 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 585035014372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035014373 putative substrate translocation pore; other site 585035014374 putative transposase; Provisional; Region: PRK09857 585035014375 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 585035014376 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 585035014377 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585035014378 DNA-binding site [nucleotide binding]; DNA binding site 585035014379 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 585035014380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 585035014381 homodimer interface [polypeptide binding]; other site 585035014382 catalytic residue [active] 585035014383 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 585035014384 endoribonuclease SymE; Provisional; Region: PRK13605 585035014385 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 585035014386 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 585035014387 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 585035014388 ATP binding site [chemical binding]; other site 585035014389 putative Mg++ binding site [ion binding]; other site 585035014390 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 585035014391 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 585035014392 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 585035014393 HsdM N-terminal domain; Region: HsdM_N; pfam12161 585035014394 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 585035014395 Methyltransferase domain; Region: Methyltransf_26; pfam13659 585035014396 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme 585035014397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 585035014398 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 585035014399 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 585035014400 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 585035014401 P-loop, Walker A motif; other site 585035014402 Base recognition motif; other site 585035014403 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 585035014404 Uncharacterized small protein [Function unknown]; Region: COG2879 585035014405 carbon starvation protein A; Provisional; Region: PRK15015 585035014406 Carbon starvation protein CstA; Region: CstA; pfam02554 585035014407 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 585035014408 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 585035014409 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 585035014410 dimer interface [polypeptide binding]; other site 585035014411 ligand binding site [chemical binding]; other site 585035014412 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585035014413 dimerization interface [polypeptide binding]; other site 585035014414 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 585035014415 dimer interface [polypeptide binding]; other site 585035014416 putative CheW interface [polypeptide binding]; other site 585035014417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035014418 D-galactonate transporter; Region: 2A0114; TIGR00893 585035014419 putative substrate translocation pore; other site 585035014420 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 585035014421 DNA-binding site [nucleotide binding]; DNA binding site 585035014422 Transcriptional regulators [Transcription]; Region: GntR; COG1802 585035014423 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 585035014424 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 585035014425 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 585035014426 putative NAD(P) binding site [chemical binding]; other site 585035014427 catalytic Zn binding site [ion binding]; other site 585035014428 structural Zn binding site [ion binding]; other site 585035014429 phosphoglycerol transferase I; Provisional; Region: PRK03776 585035014430 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 585035014431 hypothetical protein; Provisional; Region: PRK11667 585035014432 DNA replication protein DnaC; Validated; Region: PRK07952 585035014433 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035014434 Walker A motif; other site 585035014435 ATP binding site [chemical binding]; other site 585035014436 Walker B motif; other site 585035014437 primosomal protein DnaI; Provisional; Region: PRK02854 585035014438 hypothetical protein; Provisional; Region: PRK09917 585035014439 Uncharacterized conserved protein [Function unknown]; Region: COG2966 585035014440 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 585035014441 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 585035014442 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585035014443 DNA binding residues [nucleotide binding] 585035014444 dimerization interface [polypeptide binding]; other site 585035014445 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 585035014446 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 585035014447 DNA binding residues [nucleotide binding] 585035014448 dimerization interface [polypeptide binding]; other site 585035014449 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 585035014450 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 585035014451 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 585035014452 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 585035014453 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 585035014454 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 585035014455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035014456 S-adenosylmethionine binding site [chemical binding]; other site 585035014457 DNA polymerase III subunit psi; Validated; Region: PRK06856 585035014458 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 585035014459 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 585035014460 Coenzyme A binding pocket [chemical binding]; other site 585035014461 dUMP phosphatase; Provisional; Region: PRK09449 585035014462 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585035014463 motif II; other site 585035014464 integrase; Provisional; Region: PRK09692 585035014465 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 585035014466 active site 585035014467 Int/Topo IB signature motif; other site 585035014468 Protein of unknown function (DUF551); Region: DUF551; pfam04448 585035014469 Ligand Binding Domain of Ephrin Receptors; Region: EphR_LBD; cl02704 585035014470 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 585035014471 Uncharacterized conserved protein [Function unknown]; Region: COG5532 585035014472 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 585035014473 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585035014474 non-specific DNA binding site [nucleotide binding]; other site 585035014475 salt bridge; other site 585035014476 sequence-specific DNA binding site [nucleotide binding]; other site 585035014477 Predicted transcriptional regulator [Transcription]; Region: COG2932 585035014478 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 585035014479 Catalytic site [active] 585035014480 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585035014481 non-specific DNA binding site [nucleotide binding]; other site 585035014482 salt bridge; other site 585035014483 sequence-specific DNA binding site [nucleotide binding]; other site 585035014484 Ash protein family; Region: Phage_ASH; pfam10554 585035014485 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 585035014486 Helix-turn-helix domain; Region: HTH_36; pfam13730 585035014487 PerC transcriptional activator; Region: PerC; pfam06069 585035014488 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 585035014489 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 585035014490 KilA-N domain; Region: KilA-N; pfam04383 585035014491 Protein of unknown function (DUF968); Region: DUF968; pfam06147 585035014492 Antitermination protein; Region: Antiterm; pfam03589 585035014493 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 585035014494 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 585035014495 Antitermination protein; Region: Antiterm; pfam03589 585035014496 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585035014497 DNA-binding site [nucleotide binding]; DNA binding site 585035014498 RNA-binding motif; other site 585035014499 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585035014500 DNA-binding site [nucleotide binding]; DNA binding site 585035014501 RNA-binding motif; other site 585035014502 Lysis protein S; Region: Lysis_S; pfam04971 585035014503 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 585035014504 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 585035014505 catalytic residues [active] 585035014506 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 585035014507 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 585035014508 DNA-binding site [nucleotide binding]; DNA binding site 585035014509 RNA-binding motif; other site 585035014510 GnsA/GnsB family; Region: GnsAB; pfam08178 585035014511 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 585035014512 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 585035014513 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 585035014514 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 585035014515 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 585035014516 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 585035014517 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 585035014518 oligomer interface [polypeptide binding]; other site 585035014519 active site residues [active] 585035014520 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 585035014521 Uncharacterized conserved protein [Function unknown]; Region: COG5471 585035014522 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 585035014523 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 585035014524 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 585035014525 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 585035014526 Bacterial Ig-like domain 2; Region: BID_2; smart00635 585035014527 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; cl06106 585035014528 Minor tail protein T; Region: Phage_tail_T; pfam06223 585035014529 Phage-related minor tail protein [Function unknown]; Region: COG5281 585035014530 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 585035014531 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 585035014532 Phage-related protein [Function unknown]; Region: COG4718 585035014533 Phage-related protein [Function unknown]; Region: gp18; COG4672 585035014534 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 585035014535 MPN+ (JAMM) motif; other site 585035014536 Zinc-binding site [ion binding]; other site 585035014537 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 585035014538 NlpC/P60 family; Region: NLPC_P60; cl17555 585035014539 Phage-related protein, tail component [Function unknown]; Region: COG4723 585035014540 Phage-related protein, tail component [Function unknown]; Region: COG4733 585035014541 Putative phage tail protein; Region: Phage-tail_3; pfam13550 585035014542 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 585035014543 Fibronectin type III protein; Region: DUF3672; pfam12421 585035014544 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 585035014545 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 585035014546 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 585035014547 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 585035014548 multiple promoter invertase; Provisional; Region: mpi; PRK13413 585035014549 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 585035014550 catalytic residues [active] 585035014551 catalytic nucleophile [active] 585035014552 Presynaptic Site I dimer interface [polypeptide binding]; other site 585035014553 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 585035014554 Synaptic Flat tetramer interface [polypeptide binding]; other site 585035014555 Synaptic Site I dimer interface [polypeptide binding]; other site 585035014556 DNA binding site [nucleotide binding] 585035014557 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 585035014558 DNA-binding interface [nucleotide binding]; DNA binding site 585035014559 DinI-like family; Region: DinI; pfam06183 585035014560 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 585035014561 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 585035014562 G1 box; other site 585035014563 putative GEF interaction site [polypeptide binding]; other site 585035014564 GTP/Mg2+ binding site [chemical binding]; other site 585035014565 Switch I region; other site 585035014566 G2 box; other site 585035014567 G3 box; other site 585035014568 Switch II region; other site 585035014569 G4 box; other site 585035014570 G5 box; other site 585035014571 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 585035014572 periplasmic protein; Provisional; Region: PRK10568 585035014573 BON domain; Region: BON; pfam04972 585035014574 BON domain; Region: BON; pfam04972 585035014575 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 585035014576 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 585035014577 active site 585035014578 nucleophile elbow; other site 585035014579 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 585035014580 active site 585035014581 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 585035014582 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 585035014583 FeS/SAM binding site; other site 585035014584 hypothetical protein; Provisional; Region: PRK10977 585035014585 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 585035014586 intersubunit interface [polypeptide binding]; other site 585035014587 active site 585035014588 catalytic residue [active] 585035014589 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 585035014590 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 585035014591 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 585035014592 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 585035014593 phosphopentomutase; Provisional; Region: PRK05362 585035014594 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 585035014595 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 585035014596 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 585035014597 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 585035014598 HipA-like N-terminal domain; Region: HipA_N; pfam07805 585035014599 HipA-like C-terminal domain; Region: HipA_C; pfam07804 585035014600 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 585035014601 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 585035014602 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 585035014603 hypothetical protein; Provisional; Region: PRK11246 585035014604 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 585035014605 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 585035014606 motif II; other site 585035014607 DNA repair protein RadA; Region: sms; TIGR00416 585035014608 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 585035014609 Walker A motif/ATP binding site; other site 585035014610 ATP binding site [chemical binding]; other site 585035014611 Walker B motif; other site 585035014612 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 585035014613 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585035014614 non-specific DNA binding site [nucleotide binding]; other site 585035014615 salt bridge; other site 585035014616 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 585035014617 sequence-specific DNA binding site [nucleotide binding]; other site 585035014618 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 585035014619 active site 585035014620 (T/H)XGH motif; other site 585035014621 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 585035014622 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 585035014623 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 585035014624 non-specific DNA binding site [nucleotide binding]; other site 585035014625 salt bridge; other site 585035014626 sequence-specific DNA binding site [nucleotide binding]; other site 585035014627 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 585035014628 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585035014629 Walker A/P-loop; other site 585035014630 ATP binding site [chemical binding]; other site 585035014631 Q-loop/lid; other site 585035014632 ABC transporter signature motif; other site 585035014633 Walker B; other site 585035014634 D-loop; other site 585035014635 H-loop/switch region; other site 585035014636 ABC transporter; Region: ABC_tran_2; pfam12848 585035014637 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 585035014638 lytic murein transglycosylase; Provisional; Region: PRK11619 585035014639 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585035014640 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585035014641 catalytic residue [active] 585035014642 Trp operon repressor; Provisional; Region: PRK01381 585035014643 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 585035014644 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 585035014645 catalytic core [active] 585035014646 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 585035014647 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 585035014648 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 585035014649 hypothetical protein; Provisional; Region: PRK10756 585035014650 CreA protein; Region: CreA; pfam05981 585035014651 DNA-binding response regulator CreB; Provisional; Region: PRK11083 585035014652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035014653 active site 585035014654 phosphorylation site [posttranslational modification] 585035014655 intermolecular recognition site; other site 585035014656 dimerization interface [polypeptide binding]; other site 585035014657 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585035014658 DNA binding site [nucleotide binding] 585035014659 sensory histidine kinase CreC; Provisional; Region: PRK11100 585035014660 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 585035014661 dimerization interface [polypeptide binding]; other site 585035014662 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 585035014663 dimer interface [polypeptide binding]; other site 585035014664 phosphorylation site [posttranslational modification] 585035014665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 585035014666 ATP binding site [chemical binding]; other site 585035014667 Mg2+ binding site [ion binding]; other site 585035014668 G-X-G motif; other site 585035014669 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 585035014670 two-component response regulator; Provisional; Region: PRK11173 585035014671 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 585035014672 active site 585035014673 phosphorylation site [posttranslational modification] 585035014674 intermolecular recognition site; other site 585035014675 dimerization interface [polypeptide binding]; other site 585035014676 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 585035014677 DNA binding site [nucleotide binding] 585035014678 putative RNA methyltransferase; Provisional; Region: PRK10433 585035014679 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 585035014680 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 585035014681 active site 585035014682 catalytic residues [active] 585035014683 DNA binding site [nucleotide binding] 585035014684 Int/Topo IB signature motif; other site 585035014685 Initiator Replication protein; Region: Rep_3; cl03080 585035014686 Transposase family tnp2; Region: Transposase_21; pfam02992 585035014687 similar to putative transposase(fragment) IS21 family; Evidence 7 : Gene remnant; Product type pe : putative enzyme 585035014688 Y-family of DNA polymerases; Region: PolY; cl12025 585035014689 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 585035014690 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 585035014691 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585035014692 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585035014693 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585035014694 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 585035014695 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585035014696 N-terminal plug; other site 585035014697 ligand-binding site [chemical binding]; other site 585035014698 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 585035014699 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 585035014700 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 585035014701 IucA / IucC family; Region: IucA_IucC; pfam04183 585035014702 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 585035014703 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 585035014704 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 585035014705 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 585035014706 IucA / IucC family; Region: IucA_IucC; pfam04183 585035014707 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 585035014708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 585035014709 Major Facilitator Superfamily; Region: MFS_1; pfam07690 585035014710 putative substrate translocation pore; other site 585035014711 chromosome condensation membrane protein; Provisional; Region: PRK14196 585035014712 Telomerase activating protein Est1; Region: EST1; pfam10374 585035014713 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 585035014714 substrate binding pocket [chemical binding]; other site 585035014715 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 585035014716 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585035014717 ABC-ATPase subunit interface; other site 585035014718 dimer interface [polypeptide binding]; other site 585035014719 putative PBP binding regions; other site 585035014720 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 585035014721 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 585035014722 ABC-ATPase subunit interface; other site 585035014723 dimer interface [polypeptide binding]; other site 585035014724 putative PBP binding regions; other site 585035014725 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 585035014726 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 585035014727 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 585035014728 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 585035014729 metal binding site [ion binding]; metal-binding site 585035014730 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585035014731 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585035014732 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585035014733 fragment of transposase (partial);Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 585035014734 Protein of unknown function, DUF270; Region: Otopetrin; pfam03189 585035014735 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 585035014736 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 585035014737 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 585035014738 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 585035014739 plasmid-partitioning protein SopA; Provisional; Region: PRK13705 585035014740 MerR family regulatory protein; Region: MerR; pfam00376 585035014741 DNA binding residues [nucleotide binding] 585035014742 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 585035014743 P-loop; other site 585035014744 Magnesium ion binding site [ion binding]; other site 585035014745 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 585035014746 Magnesium ion binding site [ion binding]; other site 585035014747 plasmid-partitioning protein; Provisional; Region: PRK13698 585035014748 ParB-like nuclease domain; Region: ParB; smart00470 585035014749 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 585035014750 Transposase; Region: DEDD_Tnp_IS110; pfam01548 585035014751 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 585035014752 Antirestriction protein; Region: Antirestrict; pfam03230 585035014753 Domain of unknown function (DUF3560); Region: DUF3560; pfam12083 585035014754 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 585035014755 S-adenosylmethionine binding site [chemical binding]; other site 585035014756 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 585035014757 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 585035014758 dimer interface [polypeptide binding]; other site 585035014759 ssDNA binding site [nucleotide binding]; other site 585035014760 tetramer (dimer of dimers) interface [polypeptide binding]; other site 585035014761 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 585035014762 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 585035014763 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 585035014764 DNA binding residues [nucleotide binding] 585035014765 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 585035014766 Integrase core domain; Region: rve; pfam00665 585035014767 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 585035014768 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 585035014769 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 585035014770 Walker A motif; other site 585035014771 ATP binding site [chemical binding]; other site 585035014772 ParB-like nuclease domain; Region: ParB; smart00470 585035014773 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 585035014774 KorB domain; Region: KorB; pfam08535 585035014775 plasmid SOS inhibition protein B; Provisional; Region: psiB; PRK13701 585035014776 plasmid SOS inhibition protein A; Provisional; Region: PRK13704 585035014777 modulator of post-segregation killing protein; Provisional; Region: PRK13720 585035014778 Domain of unknown function (DUF932); Region: DUF932; pfam06067 585035014779 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 585035014780 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 585035014781 N-acetyl-D-glucosamine binding site [chemical binding]; other site 585035014782 catalytic residue [active] 585035014783 TraM protein; Region: Tra_M; pfam05261 585035014784 conjugal transfer transcriptional regulator TraJ; Provisional; Region: PRK13719 585035014785 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 585035014786 conjugal transfer protein TraY; Provisional; Region: PRK13740 585035014787 TraY domain; Region: TraY; cl17675 585035014788 conjugal transfer pilin subunit TraA; Provisional; Region: PRK13734 585035014789 conjugal transfer pilus assembly protein TraL; Provisional; Region: PRK13707 585035014790 conjugal transfer pilus assembly protein TraE; Provisional; Region: PRK13726 585035014791 conjugal transfer protein TraK; Provisional; Region: PRK13736 585035014792 TraK protein; Region: TraK; pfam06586 585035014793 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 585035014794 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 585035014795 conjugal transfer protein TraP; Provisional; Region: PRK13739 585035014796 conjugal transfer protein TrbD; Provisional; Region: PRK13724 585035014797 conjugal transfer protein TrbG; Provisional; Region: PRK13744 585035014798 conjugal transfer protein TraV; Provisional; Region: PRK13733 585035014799 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 585035014800 conjugal transfer protein TraR; Provisional; Region: PRK13715 585035014801 conjugal transfer ATP-binding protein TraC; Provisional; Region: PRK13721 585035014802 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 585035014803 conjugal transfer protein TrbI; Provisional; Region: PRK13717 585035014804 conjugal transfer pilus assembly protein TraW; Provisional; Region: PRK13738 585035014805 conjugal transfer pilus assembly protein TraU; Provisional; Region: PRK13737 585035014806 conjugal transfer pilus assembly protein TrbC; Provisional; Region: PRK13730 585035014807 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 585035014808 conjugal transfer protein TrbE; Provisional; Region: PRK13718 585035014809 conjugal pilus assembly protein TraF; Provisional; Region: PRK13703 585035014810 F plasmid transfer operon protein; Region: TraF; pfam13728 585035014811 Type-F conjugative transfer system pilin chaperone (TraQ); Region: TraQ; cl11516 585035014812 conjugal transfer protein TrbB; Provisional; Region: PRK13728 585035014813 conjugal transfer protein TrbJ; Provisional; Region: PRK13711 585035014814 conjugal transfer pilus assembly protein TraH; Provisional; Region: PRK13723 585035014815 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 585035014816 Plasmid conjugative transfer entry exclusion protein TraS; Region: TraS; pfam10624 585035014817 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 585035014818 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 585035014819 conjugal transfer protein TraD; Provisional; Region: PRK13700 585035014820 F sex factor protein N terminal; Region: TraD_N; pfam12615 585035014821 Bacterial conjugation protein TrwB, ATP binding domain. TrwB is a homohexamer encoded by conjugative plasmids in Gram-negative bacteria. TrwB also has an all alpha domain which has been hypothesized to be responsible for DNA binding. TrwB is a component...; Region: TrwB; cd01127 585035014822 multimer interface [polypeptide binding]; other site 585035014823 Walker A motif; other site 585035014824 ATP binding site [chemical binding]; other site 585035014825 Walker B motif; other site 585035014826 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 585035014827 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 585035014828 AAA domain; Region: AAA_30; pfam13604 585035014829 DNA helicase TraI; Region: TraI; pfam07057 585035014830 conjugal transfer pilus acetylation protein TraX; Provisional; Region: PRK13706 585035014831 conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754 585035014832 Fertility inhibition protein N terminal; Region: FinO_N; pfam12602 585035014833 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 585035014834 putative RNA binding sites [nucleotide binding]; other site 585035014835 Staphylococcal nuclease homologues; Region: SNc; smart00318 585035014836 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 585035014837 Catalytic site; other site 585035014838 replication protein; Provisional; Region: PRK13702 585035014839 replication protein; Provisional; Region: PRK13750 585035014840 Predicted transcriptional regulator [Transcription]; Region: COG3905 585035014841 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 585035014842 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 585035014843 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 585035014844 active site 585035014845 catalytic site [active] 585035014846 substrate binding site [chemical binding]; other site 585035014847 Colicin Ia; Region: Colicin_Ia; pfam11504 585035014848 Colicin pore forming domain; Region: Colicin; pfam01024 585035014849 Colicin E1 (microcin) immunity protein; Region: Microcin; pfam03526 585035014850 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 585035014851 putative trimer interface [polypeptide binding]; other site 585035014852 putative active site [active] 585035014853 putative substrate binding site [chemical binding]; other site 585035014854 putative CoA binding site [chemical binding]; other site 585035014855 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 585035014856 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 585035014857 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 585035014858 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 585035014859 putative active site [active] 585035014860 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585035014861 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 585035014862 Walker A/P-loop; other site 585035014863 ATP binding site [chemical binding]; other site 585035014864 Q-loop/lid; other site 585035014865 ABC transporter signature motif; other site 585035014866 Walker B; other site 585035014867 D-loop; other site 585035014868 H-loop/switch region; other site 585035014869 HlyD family secretion protein; Region: HlyD; pfam00529 585035014870 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585035014871 HlyD family secretion protein; Region: HlyD_3; pfam13437 585035014872 Predicted transcriptional regulator [Transcription]; Region: COG3905 585035014873 fragment of putative plasmid stabilisation system protein YacB;Evidence 7 : Gene remnant; Product type pe : putative enzyme 585035014874 fragment of conserved hypothetical protein YbaA;Evidence 7 : Gene remnant 585035014875 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260 585035014876 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 585035014877 outer membrane receptor FepA; Provisional; Region: PRK13528 585035014878 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 585035014879 N-terminal plug; other site 585035014880 ligand-binding site [chemical binding]; other site 585035014881 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 585035014882 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 585035014883 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 585035014884 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 585035014885 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585035014886 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 585035014887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585035014888 Walker A/P-loop; other site 585035014889 ATP binding site [chemical binding]; other site 585035014890 Q-loop/lid; other site 585035014891 ABC transporter signature motif; other site 585035014892 Walker B; other site 585035014893 D-loop; other site 585035014894 H-loop/switch region; other site 585035014895 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 585035014896 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 585035014897 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 585035014898 Walker A/P-loop; other site 585035014899 ATP binding site [chemical binding]; other site 585035014900 Q-loop/lid; other site 585035014901 ABC transporter signature motif; other site 585035014902 Walker B; other site 585035014903 D-loop; other site 585035014904 H-loop/switch region; other site 585035014905 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 585035014906 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 585035014907 homodimer interface [polypeptide binding]; other site 585035014908 active site 585035014909 TDP-binding site; other site 585035014910 acceptor substrate-binding pocket; other site 585035014911 Integrase core domain; Region: rve; pfam00665 585035014912 Integrase core domain; Region: rve_3; pfam13683 585035014913 Helix-turn-helix domain; Region: HTH_28; pfam13518 585035014914 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 585035014915 Bor protein; Region: Lambda_Bor; pfam06291 585035014916 IS2 repressor TnpA; Reviewed; Region: PRK09413 585035014917 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 585035014918 IS2 transposase TnpB; Reviewed; Region: PRK09409 585035014919 HTH-like domain; Region: HTH_21; pfam13276 585035014920 Integrase core domain; Region: rve; pfam00665 585035014921 Integrase core domain; Region: rve_3; pfam13683 585035014922 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 585035014923 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 585035014924 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 585035014925 Integrase core domain; Region: rve; pfam00665 585035014926 Winged helix-turn helix; Region: HTH_29; pfam13551 585035014927 Helix-turn-helix domain; Region: HTH_28; pfam13518 585035014928 Homeodomain-like domain; Region: HTH_32; pfam13565 585035014929 Integrase core domain; Region: rve; pfam00665 585035014930 putative transposase (fragment);Evidence 7 : Gene remnant 585035014931 putative transposase (fragment);Evidence 7 : Gene remnant 585035014932 Abortive infection C-terminus; Region: Abi_C; pfam14355 585035014933 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 585035014934 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 585035014935 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 585035014936 Walker A/P-loop; other site 585035014937 ATP binding site [chemical binding]; other site 585035014938 Q-loop/lid; other site 585035014939 ABC transporter signature motif; other site 585035014940 Walker B; other site 585035014941 D-loop; other site 585035014942 H-loop/switch region; other site 585035014943 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 585035014944 FtsX-like permease family; Region: FtsX; pfam02687 585035014945 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 585035014946 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 585035014947 HlyD family secretion protein; Region: HlyD_3; pfam13437 585035014948 putative transposase ORF B (fragment), IS3 family;Evidence 7 : Gene remnant; Product type pe : putative enzyme 585035014949 putative transposase ORF B (fragment), IS3 family;Evidence 7 : Gene remnant; Product type pe : putative enzyme 585035014950 putative transposase OrfB; Reviewed; Region: PHA02517 585035014951 HTH-like domain; Region: HTH_21; pfam13276 585035014952 Integrase core domain; Region: rve; pfam00665 585035014953 Integrase core domain; Region: rve_3; pfam13683 585035014954 Transposase; Region: HTH_Tnp_1; cl17663 585035014955 putative transposase ORF B (fragment), IS3 family, IS407 group;Evidence 7 : Gene remnant; Product type pe : putative enzyme 585035014956 outer membrane protease; Reviewed; Region: PRK10993 585035014957 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 585035014958 NAD(P) binding site [chemical binding]; other site 585035014959 active site 585035014960 antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312