-- dump date 20140619_091004 -- class Genbank::misc_feature -- table misc_feature_note -- id note 869729000001 Haemolysin expression modulating protein; Region: HHA; pfam05321 869729000002 Staphylococcal nuclease homologues; Region: SNc; smart00318 869729000003 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 869729000004 Catalytic site; other site 869729000005 conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754 869729000006 Fertility inhibition protein N terminal; Region: FinO_N; pfam12602 869729000007 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 869729000008 putative RNA binding sites [nucleotide binding]; other site 869729000009 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 869729000010 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 869729000011 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 869729000012 TraX protein; Region: TraX; cl05434 869729000013 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 869729000014 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 869729000015 AAA domain; Region: AAA_30; pfam13604 869729000016 DNA helicase TraI; Region: TraI; pfam07057 869729000017 conjugal transfer protein TraD; Provisional; Region: PRK13700 869729000018 F sex factor protein N terminal; Region: TraD_N; pfam12615 869729000019 Bacterial conjugation protein TrwB, ATP binding domain. TrwB is a homohexamer encoded by conjugative plasmids in Gram-negative bacteria. TrwB also has an all alpha domain which has been hypothesized to be responsible for DNA binding. TrwB is a component...; Region: TrwB; cd01127 869729000020 multimer interface [polypeptide binding]; other site 869729000021 Walker A motif; other site 869729000022 ATP binding site [chemical binding]; other site 869729000023 Walker B motif; other site 869729000024 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 869729000025 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 869729000026 Plasmid conjugative transfer entry exclusion protein TraS; Region: TraS; pfam10624 869729000027 conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735 869729000028 conjugal transfer pilus assembly protein TraH; Provisional; Region: PRK13723 869729000029 conjugal transfer protein TrbJ; Provisional; Region: PRK13711 869729000030 conjugal transfer protein TrbF; Provisional; Region: PRK13743 869729000031 conjugal transfer protein TrbB; Provisional; Region: PRK13728 869729000032 conjugal transfer pilin chaperone TraQ; Provisional; Region: PRK13727 869729000033 conjugal transfer protein TrbA; Provisional; Region: PRK13712 869729000034 conjugal pilus assembly protein TraF; Provisional; Region: PRK13703 869729000035 F plasmid transfer operon protein; Region: TraF; pfam13728 869729000036 conjugal transfer protein TrbE; Provisional; Region: PRK13718 869729000037 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 869729000038 conjugal transfer pilus assembly protein TrbC; Provisional; Region: PRK13730 869729000039 potential frameshift: common BLAST hit: gi|302595527|ref|YP_003829145.1| F pilin assembly 869729000040 TraU protein; Region: TraU; cl06067 869729000041 TraU protein; Region: TraU; cl06067 869729000042 conjugal transfer pilus assembly protein TraW; Provisional; Region: PRK13738 869729000043 conjugal transfer protein TrbI; Provisional; Region: PRK13717 869729000044 conjugal transfer ATP-binding protein TraC; Provisional; Region: PRK13721 869729000045 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 869729000046 conjugal transfer protein TraR; Provisional; Region: PRK13715 869729000047 conjugal transfer protein TraV; Provisional; Region: PRK13733 869729000048 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 869729000049 conjugal transfer protein TrbG; Provisional; Region: PRK13744 869729000050 conjugal transfer protein TrbD; Provisional; Region: PRK13724 869729000051 conjugal transfer protein TraP; Provisional; Region: PRK13739 869729000052 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 869729000053 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 869729000054 conjugal transfer protein TraK; Provisional; Region: PRK13736 869729000055 TraK protein; Region: TraK; pfam06586 869729000056 conjugal transfer pilus assembly protein TraE; Provisional; Region: PRK13726 869729000057 conjugal transfer pilus assembly protein TraL; Provisional; Region: PRK13707 869729000058 conjugal transfer pilin subunit TraA; Provisional; Region: PRK13734 869729000059 conjugal transfer protein TraY; Provisional; Region: PRK13740 869729000060 PAS fold; Region: PAS; pfam00989 869729000061 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 869729000062 TraM protein; Region: Tra_M; pfam05261 869729000063 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 869729000064 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 869729000065 N-acetyl-D-glucosamine binding site [chemical binding]; other site 869729000066 catalytic residue [active] 869729000067 Domain of unknown function (DUF932); Region: DUF932; pfam06067 869729000068 small toxic polypeptide; Provisional; Region: PRK09738 869729000069 modulator of post-segregation killing protein; Provisional; Region: PRK13720 869729000070 plasmid SOS inhibition protein A; Provisional; Region: PRK13704 869729000071 plasmid SOS inhibition protein B; Provisional; Region: psiB; PRK13701 869729000072 ParB-like nuclease domain; Region: ParB; smart00470 869729000073 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 869729000074 KorB domain; Region: KorB; pfam08535 869729000075 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 869729000076 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 869729000077 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 869729000078 dimer interface [polypeptide binding]; other site 869729000079 ssDNA binding site [nucleotide binding]; other site 869729000080 tetramer (dimer of dimers) interface [polypeptide binding]; other site 869729000081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729000082 S-adenosylmethionine binding site [chemical binding]; other site 869729000083 Domain of unknown function (DUF3560); Region: DUF3560; pfam12083 869729000084 Mu B transposition protein, C terminal; Region: Phage-MuB_C; pfam09077 869729000085 Antirestriction protein; Region: Antirestrict; pfam03230 869729000086 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 869729000087 putative methylase; Provisional; Region: PRK13699 869729000088 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 869729000089 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 869729000090 Integrase core domain; Region: rve; pfam00665 869729000091 Integrase core domain; Region: rve_3; cl15866 869729000092 transposase/IS protein; Provisional; Region: PRK09183 869729000093 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729000094 Walker A motif; other site 869729000095 ATP binding site [chemical binding]; other site 869729000096 Walker B motif; other site 869729000097 arginine finger; other site 869729000098 Protein of unknown function (DUF1281); Region: DUF1281; pfam06924 869729000099 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 869729000100 Transposase; Region: DDE_Tnp_ISL3; pfam01610 869729000101 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 869729000102 DinI-like family; Region: DinI; pfam06183 869729000103 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 869729000104 Catalytic site [active] 869729000105 potential frameshift: common BLAST hit: gi|256855307|ref|YP_003162551.1| DNA repair protein UmuC 869729000106 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 869729000107 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 869729000108 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 869729000109 Mg binding site [ion binding]; other site 869729000110 nucleotide binding site [chemical binding]; other site 869729000111 putative protofilament interface [polypeptide binding]; other site 869729000112 ParA-like protein; Provisional; Region: PHA02518 869729000113 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 869729000114 P-loop; other site 869729000115 Magnesium ion binding site [ion binding]; other site 869729000116 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 869729000117 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 869729000118 potential frameshift: common BLAST hit: gi|256855302|ref|YP_003162546.1| putative resolvase 869729000119 plasmid maintenance protein CcdB; Provisional; Region: PRK13708 869729000120 plasmid maintenance protein CcdA; Provisional; Region: PRK13710 869729000121 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 869729000122 active site 869729000123 catalytic residues [active] 869729000124 DNA binding site [nucleotide binding] 869729000125 Int/Topo IB signature motif; other site 869729000126 IS2 transposase TnpB; Reviewed; Region: PRK09409 869729000127 IS2 repressor TnpA; Reviewed; Region: PRK09413 869729000128 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 869729000129 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 869729000130 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 869729000131 N-terminal plug; other site 869729000132 ligand-binding site [chemical binding]; other site 869729000133 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 869729000134 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 869729000135 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 869729000136 transposase/IS protein; Provisional; Region: PRK09183 869729000137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729000138 Walker A motif; other site 869729000139 ATP binding site [chemical binding]; other site 869729000140 Walker B motif; other site 869729000141 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 869729000142 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 869729000143 DNA-binding interface [nucleotide binding]; DNA binding site 869729000144 Integrase core domain; Region: rve; pfam00665 869729000145 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 869729000146 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 869729000147 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 869729000148 phosphodiesterase; Provisional; Region: PRK12704 869729000149 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 869729000150 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 869729000151 Transposase; Region: HTH_Tnp_1; pfam01527 869729000152 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 869729000153 Integrase core domain; Region: rve; pfam00665 869729000154 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 869729000155 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 869729000156 putative active site [active] 869729000157 putative NTP binding site [chemical binding]; other site 869729000158 putative nucleic acid binding site [nucleotide binding]; other site 869729000159 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 869729000160 putative transposase OrfB; Reviewed; Region: PHA02517 869729000161 Integrase core domain; Region: rve; pfam00665 869729000162 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 869729000163 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729000164 Walker A motif; other site 869729000165 ATP binding site [chemical binding]; other site 869729000166 Walker B motif; other site 869729000167 Transposase; Region: HTH_Tnp_1; cl17663 869729000168 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 869729000169 Uncharacterized conserved protein [Function unknown]; Region: COG3391 869729000170 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 869729000171 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 869729000172 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 869729000173 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 869729000174 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 869729000175 Protein of unknown function, DUF399; Region: DUF399; pfam04187 869729000176 Replicase family; Region: Replicase; pfam03090 869729000177 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 869729000178 Colicin E1 (microcin) immunity protein; Region: Microcin; pfam03526 869729000179 Transposase; Region: HTH_Tnp_1; cl17663 869729000180 HTH-like domain; Region: HTH_21; pfam13276 869729000181 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 869729000182 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 869729000183 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 869729000184 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 869729000185 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 869729000186 catalytic core [active] 869729000187 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 869729000188 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 869729000189 catalytic residues [active] 869729000190 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869729000191 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869729000192 Walker A/P-loop; other site 869729000193 ATP binding site [chemical binding]; other site 869729000194 Q-loop/lid; other site 869729000195 ABC transporter signature motif; other site 869729000196 Walker B; other site 869729000197 D-loop; other site 869729000198 H-loop/switch region; other site 869729000199 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 869729000200 FtsX-like permease family; Region: FtsX; pfam02687 869729000201 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 869729000202 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 869729000203 FtsX-like permease family; Region: FtsX; pfam02687 869729000204 Predicted membrane protein [Function unknown]; Region: COG4393 869729000205 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 869729000206 Uncharacterized conserved protein [Function unknown]; Region: COG3350 869729000207 Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470 869729000208 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 869729000209 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 869729000210 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 869729000211 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 869729000212 catalytic residues [active] 869729000213 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 869729000214 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 869729000215 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 869729000216 Integrase core domain; Region: rve; pfam00665 869729000217 replication protein; Provisional; Region: PRK13750 869729000218 replication protein; Provisional; Region: PRK13702 869729000219 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 869729000220 potential RNA of insufficient length (23S ribosomal RNA) 869729000221 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 869729000222 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 869729000223 Walker A/P-loop; other site 869729000224 ATP binding site [chemical binding]; other site 869729000225 Q-loop/lid; other site 869729000226 ABC transporter signature motif; other site 869729000227 Walker B; other site 869729000228 D-loop; other site 869729000229 H-loop/switch region; other site 869729000230 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 869729000231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729000232 dimer interface [polypeptide binding]; other site 869729000233 conserved gate region; other site 869729000234 putative PBP binding loops; other site 869729000235 ABC-ATPase subunit interface; other site 869729000236 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 869729000237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729000238 conserved gate region; other site 869729000239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729000240 dimer interface [polypeptide binding]; other site 869729000241 conserved gate region; other site 869729000242 putative PBP binding loops; other site 869729000243 ABC-ATPase subunit interface; other site 869729000244 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 869729000245 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869729000246 substrate binding pocket [chemical binding]; other site 869729000247 membrane-bound complex binding site; other site 869729000248 hinge residues; other site 869729000249 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 869729000250 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 869729000251 Protein export membrane protein; Region: SecD_SecF; cl14618 869729000252 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 869729000253 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 869729000254 HlyD family secretion protein; Region: HlyD_3; pfam13437 869729000255 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 869729000256 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869729000257 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 869729000258 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 869729000259 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 869729000260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729000261 DNA methylase; Region: N6_N4_Mtase; pfam01555 869729000262 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 869729000263 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 869729000264 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 869729000265 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 869729000266 FMN binding site [chemical binding]; other site 869729000267 active site 869729000268 catalytic residues [active] 869729000269 substrate binding site [chemical binding]; other site 869729000270 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 869729000271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 869729000272 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 869729000273 Na binding site [ion binding]; other site 869729000274 hypothetical protein; Provisional; Region: PRK10633 869729000275 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 869729000276 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 869729000277 substrate binding site [chemical binding]; other site 869729000278 ATP binding site [chemical binding]; other site 869729000279 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 869729000280 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 869729000281 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869729000282 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 869729000283 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 869729000284 intersubunit interface [polypeptide binding]; other site 869729000285 active site 869729000286 zinc binding site [ion binding]; other site 869729000287 Na+ binding site [ion binding]; other site 869729000288 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 869729000289 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_12; cd06322 869729000290 putative ligand binding site [chemical binding]; other site 869729000291 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 869729000292 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 869729000293 Walker A/P-loop; other site 869729000294 ATP binding site [chemical binding]; other site 869729000295 Q-loop/lid; other site 869729000296 ABC transporter signature motif; other site 869729000297 Walker B; other site 869729000298 D-loop; other site 869729000299 H-loop/switch region; other site 869729000300 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 869729000301 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869729000302 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 869729000303 TM-ABC transporter signature motif; other site 869729000304 potential frameshift: common BLAST hit: gi|260870001|ref|YP_003236403.1| possible sugar kinase 869729000305 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 869729000306 active site 869729000307 catalytic residues [active] 869729000308 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 869729000309 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 869729000310 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 869729000311 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 869729000312 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 869729000313 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 869729000314 carboxyltransferase (CT) interaction site; other site 869729000315 biotinylation site [posttranslational modification]; other site 869729000316 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 869729000317 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 869729000318 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 869729000319 NADP binding site [chemical binding]; other site 869729000320 dimer interface [polypeptide binding]; other site 869729000321 regulatory protein CsrD; Provisional; Region: PRK11059 869729000322 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 869729000323 metal binding site [ion binding]; metal-binding site 869729000324 active site 869729000325 I-site; other site 869729000326 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 869729000327 rod shape-determining protein MreB; Provisional; Region: PRK13927 869729000328 MreB and similar proteins; Region: MreB_like; cd10225 869729000329 nucleotide binding site [chemical binding]; other site 869729000330 Mg binding site [ion binding]; other site 869729000331 putative protofilament interaction site [polypeptide binding]; other site 869729000332 RodZ interaction site [polypeptide binding]; other site 869729000333 rod shape-determining protein MreC; Region: mreC; TIGR00219 869729000334 rod shape-determining protein MreC; Region: MreC; pfam04085 869729000335 rod shape-determining protein MreD; Provisional; Region: PRK11060 869729000336 Maf-like protein; Region: Maf; pfam02545 869729000337 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 869729000338 active site 869729000339 dimer interface [polypeptide binding]; other site 869729000340 ribonuclease G; Provisional; Region: PRK11712 869729000341 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 869729000342 homodimer interface [polypeptide binding]; other site 869729000343 oligonucleotide binding site [chemical binding]; other site 869729000344 hypothetical protein; Provisional; Region: PRK10899 869729000345 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 869729000346 protease TldD; Provisional; Region: tldD; PRK10735 869729000347 transcriptional regulator; Provisional; Region: PRK10632 869729000348 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729000349 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 869729000350 putative effector binding pocket; other site 869729000351 dimerization interface [polypeptide binding]; other site 869729000352 efflux system membrane protein; Provisional; Region: PRK11594 869729000353 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 869729000354 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 869729000355 HlyD family secretion protein; Region: HlyD_3; pfam13437 869729000356 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 869729000357 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 869729000358 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 869729000359 RNAase interaction site [polypeptide binding]; other site 869729000360 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 869729000361 arginine repressor; Provisional; Region: PRK05066 869729000362 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 869729000363 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 869729000364 malate dehydrogenase; Provisional; Region: PRK05086 869729000365 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 869729000366 NAD binding site [chemical binding]; other site 869729000367 dimerization interface [polypeptide binding]; other site 869729000368 Substrate binding site [chemical binding]; other site 869729000369 serine endoprotease; Provisional; Region: PRK10898 869729000370 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 869729000371 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 869729000372 serine endoprotease; Provisional; Region: PRK10139 869729000373 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 869729000374 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 869729000375 protein binding site [polypeptide binding]; other site 869729000376 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 869729000377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 869729000378 hypothetical protein; Provisional; Region: PRK11677 869729000379 Predicted ATPase [General function prediction only]; Region: COG1485 869729000380 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 869729000381 23S rRNA interface [nucleotide binding]; other site 869729000382 L3 interface [polypeptide binding]; other site 869729000383 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 869729000384 stringent starvation protein A; Provisional; Region: sspA; PRK09481 869729000385 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 869729000386 C-terminal domain interface [polypeptide binding]; other site 869729000387 putative GSH binding site (G-site) [chemical binding]; other site 869729000388 dimer interface [polypeptide binding]; other site 869729000389 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 869729000390 dimer interface [polypeptide binding]; other site 869729000391 N-terminal domain interface [polypeptide binding]; other site 869729000392 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 869729000393 transcriptional regulator NanR; Provisional; Region: PRK03837 869729000394 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869729000395 DNA-binding site [nucleotide binding]; DNA binding site 869729000396 FCD domain; Region: FCD; pfam07729 869729000397 N-acetylneuraminate lyase; Region: nanA; TIGR00683 869729000398 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 869729000399 inhibitor site; inhibition site 869729000400 active site 869729000401 dimer interface [polypeptide binding]; other site 869729000402 catalytic residue [active] 869729000403 putative sialic acid transporter; Provisional; Region: PRK03893 869729000404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729000405 putative substrate translocation pore; other site 869729000406 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 869729000407 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 869729000408 putative active site cavity [active] 869729000409 N-acetylmannosamine kinase; Provisional; Region: PRK05082 869729000410 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 869729000411 nucleotide binding site [chemical binding]; other site 869729000412 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 869729000413 Domain of unknown function (DUF386); Region: DUF386; cl01047 869729000414 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 869729000415 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869729000416 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869729000417 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 869729000418 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 869729000419 dimer interface [polypeptide binding]; other site 869729000420 active site 869729000421 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 869729000422 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 869729000423 active site 869729000424 FMN binding site [chemical binding]; other site 869729000425 substrate binding site [chemical binding]; other site 869729000426 3Fe-4S cluster binding site [ion binding]; other site 869729000427 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 869729000428 domain interface; other site 869729000429 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 869729000430 radical SAM protein, TIGR01212 family; Region: TIGR01212 869729000431 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869729000432 FeS/SAM binding site; other site 869729000433 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 869729000434 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869729000435 putative active site [active] 869729000436 heme pocket [chemical binding]; other site 869729000437 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869729000438 dimer interface [polypeptide binding]; other site 869729000439 phosphorylation site [posttranslational modification] 869729000440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729000441 ATP binding site [chemical binding]; other site 869729000442 Mg2+ binding site [ion binding]; other site 869729000443 G-X-G motif; other site 869729000444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729000445 active site 869729000446 phosphorylation site [posttranslational modification] 869729000447 intermolecular recognition site; other site 869729000448 dimerization interface [polypeptide binding]; other site 869729000449 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 869729000450 putative binding surface; other site 869729000451 active site 869729000452 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 869729000453 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 869729000454 conserved cys residue [active] 869729000455 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 869729000456 Transglycosylase; Region: Transgly; cl17702 869729000457 hypothetical protein; Provisional; Region: PRK10345 869729000458 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 869729000459 dimerization domain swap beta strand [polypeptide binding]; other site 869729000460 regulatory protein interface [polypeptide binding]; other site 869729000461 active site 869729000462 regulatory phosphorylation site [posttranslational modification]; other site 869729000463 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 869729000464 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869729000465 active site 869729000466 phosphorylation site [posttranslational modification] 869729000467 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 869729000468 30S subunit binding site; other site 869729000469 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 869729000470 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 869729000471 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 869729000472 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 869729000473 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 869729000474 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 869729000475 Walker A/P-loop; other site 869729000476 ATP binding site [chemical binding]; other site 869729000477 Q-loop/lid; other site 869729000478 ABC transporter signature motif; other site 869729000479 Walker B; other site 869729000480 D-loop; other site 869729000481 H-loop/switch region; other site 869729000482 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 869729000483 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 869729000484 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 869729000485 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 869729000486 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 869729000487 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 869729000488 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 869729000489 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 869729000490 putative active site [active] 869729000491 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 869729000492 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 869729000493 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 869729000494 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 869729000495 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 869729000496 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 869729000497 Walker A/P-loop; other site 869729000498 ATP binding site [chemical binding]; other site 869729000499 Q-loop/lid; other site 869729000500 ABC transporter signature motif; other site 869729000501 Walker B; other site 869729000502 D-loop; other site 869729000503 H-loop/switch region; other site 869729000504 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 869729000505 conserved hypothetical integral membrane protein; Region: TIGR00056 869729000506 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 869729000507 mce related protein; Region: MCE; pfam02470 869729000508 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 869729000509 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 869729000510 anti sigma factor interaction site; other site 869729000511 regulatory phosphorylation site [posttranslational modification]; other site 869729000512 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 869729000513 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 869729000514 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 869729000515 hinge; other site 869729000516 active site 869729000517 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 869729000518 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 869729000519 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 869729000520 substrate binding pocket [chemical binding]; other site 869729000521 chain length determination region; other site 869729000522 substrate-Mg2+ binding site; other site 869729000523 catalytic residues [active] 869729000524 aspartate-rich region 1; other site 869729000525 active site lid residues [active] 869729000526 aspartate-rich region 2; other site 869729000527 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 869729000528 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 869729000529 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 869729000530 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 869729000531 EamA-like transporter family; Region: EamA; pfam00892 869729000532 GTPase CgtA; Reviewed; Region: obgE; PRK12298 869729000533 GTP1/OBG; Region: GTP1_OBG; pfam01018 869729000534 Obg GTPase; Region: Obg; cd01898 869729000535 G1 box; other site 869729000536 GTP/Mg2+ binding site [chemical binding]; other site 869729000537 Switch I region; other site 869729000538 G2 box; other site 869729000539 G3 box; other site 869729000540 Switch II region; other site 869729000541 G4 box; other site 869729000542 G5 box; other site 869729000543 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 869729000544 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 869729000545 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 869729000546 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 869729000547 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 869729000548 RNA-binding protein YhbY; Provisional; Region: PRK10343 869729000549 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 869729000550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729000551 S-adenosylmethionine binding site [chemical binding]; other site 869729000552 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 869729000553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729000554 Walker A motif; other site 869729000555 ATP binding site [chemical binding]; other site 869729000556 Walker B motif; other site 869729000557 arginine finger; other site 869729000558 Peptidase family M41; Region: Peptidase_M41; pfam01434 869729000559 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 869729000560 dihydropteroate synthase; Region: DHPS; TIGR01496 869729000561 substrate binding pocket [chemical binding]; other site 869729000562 dimer interface [polypeptide binding]; other site 869729000563 inhibitor binding site; inhibition site 869729000564 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 869729000565 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 869729000566 active site 869729000567 substrate binding site [chemical binding]; other site 869729000568 metal binding site [ion binding]; metal-binding site 869729000569 Preprotein translocase SecG subunit; Region: SecG; pfam03840 869729000570 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 869729000571 Sulfatase; Region: Sulfatase; pfam00884 869729000572 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 869729000573 ANP binding site [chemical binding]; other site 869729000574 Substrate Binding Site II [chemical binding]; other site 869729000575 Substrate Binding Site I [chemical binding]; other site 869729000576 ribosome maturation protein RimP; Reviewed; Region: PRK00092 869729000577 hypothetical protein; Provisional; Region: PRK14641 869729000578 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 869729000579 putative oligomer interface [polypeptide binding]; other site 869729000580 putative RNA binding site [nucleotide binding]; other site 869729000581 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 869729000582 NusA N-terminal domain; Region: NusA_N; pfam08529 869729000583 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 869729000584 RNA binding site [nucleotide binding]; other site 869729000585 homodimer interface [polypeptide binding]; other site 869729000586 NusA-like KH domain; Region: KH_5; pfam13184 869729000587 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 869729000588 G-X-X-G motif; other site 869729000589 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 869729000590 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 869729000591 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 869729000592 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 869729000593 translation initiation factor IF-2; Region: IF-2; TIGR00487 869729000594 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 869729000595 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 869729000596 G1 box; other site 869729000597 putative GEF interaction site [polypeptide binding]; other site 869729000598 GTP/Mg2+ binding site [chemical binding]; other site 869729000599 Switch I region; other site 869729000600 G2 box; other site 869729000601 G3 box; other site 869729000602 Switch II region; other site 869729000603 G4 box; other site 869729000604 G5 box; other site 869729000605 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 869729000606 Translation-initiation factor 2; Region: IF-2; pfam11987 869729000607 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 869729000608 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 869729000609 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 869729000610 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 869729000611 RNA binding site [nucleotide binding]; other site 869729000612 active site 869729000613 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 869729000614 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 869729000615 16S/18S rRNA binding site [nucleotide binding]; other site 869729000616 S13e-L30e interaction site [polypeptide binding]; other site 869729000617 25S rRNA binding site [nucleotide binding]; other site 869729000618 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 869729000619 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 869729000620 RNase E interface [polypeptide binding]; other site 869729000621 trimer interface [polypeptide binding]; other site 869729000622 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 869729000623 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 869729000624 RNase E interface [polypeptide binding]; other site 869729000625 trimer interface [polypeptide binding]; other site 869729000626 active site 869729000627 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 869729000628 putative nucleic acid binding region [nucleotide binding]; other site 869729000629 G-X-X-G motif; other site 869729000630 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 869729000631 RNA binding site [nucleotide binding]; other site 869729000632 domain interface; other site 869729000633 lipoprotein NlpI; Provisional; Region: PRK11189 869729000634 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869729000635 binding surface 869729000636 TPR motif; other site 869729000637 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 869729000638 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 869729000639 ATP binding site [chemical binding]; other site 869729000640 Mg++ binding site [ion binding]; other site 869729000641 motif III; other site 869729000642 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869729000643 nucleotide binding region [chemical binding]; other site 869729000644 ATP-binding site [chemical binding]; other site 869729000645 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 869729000646 putative RNA binding site [nucleotide binding]; other site 869729000647 tryptophan permease; Provisional; Region: PRK10483 869729000648 aromatic amino acid transport protein; Region: araaP; TIGR00837 869729000649 hypothetical protein; Provisional; Region: PRK10508 869729000650 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 869729000651 putative protease; Provisional; Region: PRK15447 869729000652 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 869729000653 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 869729000654 Peptidase family U32; Region: Peptidase_U32; pfam01136 869729000655 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 869729000656 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 869729000657 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869729000658 Coenzyme A binding pocket [chemical binding]; other site 869729000659 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 869729000660 GIY-YIG motif/motif A; other site 869729000661 putative active site [active] 869729000662 putative metal binding site [ion binding]; other site 869729000663 hypothetical protein; Provisional; Region: PRK03467 869729000664 intracellular protease, PfpI family; Region: PfpI; TIGR01382 869729000665 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 869729000666 proposed catalytic triad [active] 869729000667 conserved cys residue [active] 869729000668 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 869729000669 NADH(P)-binding; Region: NAD_binding_10; pfam13460 869729000670 NAD binding site [chemical binding]; other site 869729000671 active site 869729000672 Predicted permease; Region: DUF318; pfam03773 869729000673 outer membrane lipoprotein; Provisional; Region: PRK11023 869729000674 BON domain; Region: BON; pfam04972 869729000675 BON domain; Region: BON; pfam04972 869729000676 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 869729000677 dimer interface [polypeptide binding]; other site 869729000678 active site 869729000679 TIGR00252 family protein; Region: TIGR00252 869729000680 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 869729000681 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 869729000682 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 869729000683 putative ligand binding site [chemical binding]; other site 869729000684 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 869729000685 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 869729000686 putative SAM binding site [chemical binding]; other site 869729000687 putative homodimer interface [polypeptide binding]; other site 869729000688 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 869729000689 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 869729000690 active site 869729000691 trimer interface [polypeptide binding]; other site 869729000692 allosteric site; other site 869729000693 active site lid [active] 869729000694 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 869729000695 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 869729000696 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 869729000697 active site 869729000698 phosphorylation site [posttranslational modification] 869729000699 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453 869729000700 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 869729000701 active site 869729000702 intersubunit interface [polypeptide binding]; other site 869729000703 zinc binding site [ion binding]; other site 869729000704 Na+ binding site [ion binding]; other site 869729000705 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 869729000706 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 869729000707 dimer interface [polypeptide binding]; other site 869729000708 active site 869729000709 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 869729000710 putative active site [active] 869729000711 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 869729000712 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 869729000713 active site 869729000714 dimer interface [polypeptide binding]; other site 869729000715 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 869729000716 active pocket/dimerization site; other site 869729000717 active site 869729000718 phosphorylation site [posttranslational modification] 869729000719 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 869729000720 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 869729000721 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 869729000722 active site 869729000723 phosphorylation site [posttranslational modification] 869729000724 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 869729000725 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 869729000726 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 869729000727 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869729000728 galactarate dehydratase; Region: galactar-dH20; TIGR03248 869729000729 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 869729000730 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 869729000731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729000732 D-galactonate transporter; Region: 2A0114; TIGR00893 869729000733 putative substrate translocation pore; other site 869729000734 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 869729000735 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 869729000736 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 869729000737 glycerate kinase I; Provisional; Region: PRK10342 869729000738 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 869729000739 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 869729000740 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729000741 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 869729000742 putative substrate binding pocket [chemical binding]; other site 869729000743 putative dimerization interface [polypeptide binding]; other site 869729000744 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 869729000745 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 869729000746 tetramer interface [polypeptide binding]; other site 869729000747 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729000748 catalytic residue [active] 869729000749 threonine/serine transporter TdcC; Provisional; Region: PRK13629 869729000750 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 869729000751 propionate/acetate kinase; Provisional; Region: PRK12379 869729000752 Acetokinase family; Region: Acetate_kinase; cl17229 869729000753 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 869729000754 Pyruvate formate lyase 1; Region: PFL1; cd01678 869729000755 coenzyme A binding site [chemical binding]; other site 869729000756 active site 869729000757 catalytic residues [active] 869729000758 glycine loop; other site 869729000759 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 869729000760 homotrimer interaction site [polypeptide binding]; other site 869729000761 putative active site [active] 869729000762 L-serine dehydratase TdcG; Provisional; Region: PRK15040 869729000763 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 869729000764 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 869729000765 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 869729000766 serine transporter; Region: stp; TIGR00814 869729000767 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 869729000768 Pirin-related protein [General function prediction only]; Region: COG1741 869729000769 Pirin; Region: Pirin; pfam02678 869729000770 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729000771 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 869729000772 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 869729000773 dimerization interface [polypeptide binding]; other site 869729000774 Predicted membrane protein [Function unknown]; Region: COG3152 869729000775 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 869729000776 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 869729000777 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 869729000778 putative dimer interface [polypeptide binding]; other site 869729000779 N-terminal domain interface [polypeptide binding]; other site 869729000780 putative substrate binding pocket (H-site) [chemical binding]; other site 869729000781 Predicted membrane protein [Function unknown]; Region: COG2259 869729000782 YqjK-like protein; Region: YqjK; pfam13997 869729000783 Predicted membrane protein [Function unknown]; Region: COG5393 869729000784 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 869729000785 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 869729000786 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 869729000787 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 869729000788 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 869729000789 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 869729000790 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869729000791 DNA-binding site [nucleotide binding]; DNA binding site 869729000792 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 869729000793 D-galactonate transporter; Region: 2A0114; TIGR00893 869729000794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729000795 putative substrate translocation pore; other site 869729000796 Glucuronate isomerase; Region: UxaC; pfam02614 869729000797 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 869729000798 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 869729000799 galactarate dehydratase; Region: galactar-dH20; TIGR03248 869729000800 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 869729000801 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 869729000802 serine/threonine transporter SstT; Provisional; Region: PRK13628 869729000803 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 869729000804 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 869729000805 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 869729000806 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 869729000807 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 869729000808 putative active site [active] 869729000809 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 869729000810 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 869729000811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729000812 S-adenosylmethionine binding site [chemical binding]; other site 869729000813 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 869729000814 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 869729000815 active site 869729000816 FMN binding site [chemical binding]; other site 869729000817 2,4-decadienoyl-CoA binding site; other site 869729000818 catalytic residue [active] 869729000819 4Fe-4S cluster binding site [ion binding]; other site 869729000820 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 869729000821 alpha-glucosidase; Provisional; Region: PRK10137 869729000822 Protein of unknown function, DUF608; Region: DUF608; pfam04685 869729000823 Trehalase; Region: Trehalase; cl17346 869729000824 inner membrane transporter YjeM; Provisional; Region: PRK15238 869729000825 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 869729000826 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 869729000827 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 869729000828 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 869729000829 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 869729000830 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 869729000831 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 869729000832 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869729000833 DNA binding site [nucleotide binding] 869729000834 domain linker motif; other site 869729000835 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 869729000836 putative dimerization interface [polypeptide binding]; other site 869729000837 putative ligand binding site [chemical binding]; other site 869729000838 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 869729000839 dimer interface [polypeptide binding]; other site 869729000840 putative tRNA-binding site [nucleotide binding]; other site 869729000841 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 869729000842 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 869729000843 inhibitor-cofactor binding pocket; inhibition site 869729000844 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729000845 catalytic residue [active] 869729000846 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869729000847 PAS fold; Region: PAS_3; pfam08447 869729000848 putative active site [active] 869729000849 heme pocket [chemical binding]; other site 869729000850 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 869729000851 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 869729000852 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 869729000853 dimer interface [polypeptide binding]; other site 869729000854 putative CheW interface [polypeptide binding]; other site 869729000855 Predicted transcriptional regulators [Transcription]; Region: COG1695 869729000856 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 869729000857 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 869729000858 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 869729000859 FAD binding pocket [chemical binding]; other site 869729000860 FAD binding motif [chemical binding]; other site 869729000861 phosphate binding motif [ion binding]; other site 869729000862 NAD binding pocket [chemical binding]; other site 869729000863 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 869729000864 active site 869729000865 SUMO-1 interface [polypeptide binding]; other site 869729000866 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 869729000867 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 869729000868 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 869729000869 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 869729000870 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 869729000871 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 869729000872 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 869729000873 DNA binding residues [nucleotide binding] 869729000874 DNA primase; Validated; Region: dnaG; PRK05667 869729000875 CHC2 zinc finger; Region: zf-CHC2; pfam01807 869729000876 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 869729000877 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 869729000878 active site 869729000879 metal binding site [ion binding]; metal-binding site 869729000880 interdomain interaction site; other site 869729000881 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 869729000882 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 869729000883 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 869729000884 UGMP family protein; Validated; Region: PRK09604 869729000885 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 869729000886 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 869729000887 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 869729000888 transmembrane helices; other site 869729000889 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 869729000890 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 869729000891 transcriptional activator TtdR; Provisional; Region: PRK09801 869729000892 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729000893 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 869729000894 putative effector binding pocket; other site 869729000895 putative dimerization interface [polypeptide binding]; other site 869729000896 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 869729000897 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 869729000898 homooctamer interface [polypeptide binding]; other site 869729000899 active site 869729000900 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 869729000901 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 869729000902 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 869729000903 active site 869729000904 NTP binding site [chemical binding]; other site 869729000905 metal binding triad [ion binding]; metal-binding site 869729000906 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 869729000907 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869729000908 Zn2+ binding site [ion binding]; other site 869729000909 Mg2+ binding site [ion binding]; other site 869729000910 SH3 domain-containing protein; Provisional; Region: PRK10884 869729000911 Bacterial SH3 domain homologues; Region: SH3b; smart00287 869729000912 Uncharacterized conserved protein [Function unknown]; Region: COG3025 869729000913 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 869729000914 putative active site [active] 869729000915 putative metal binding residues [ion binding]; other site 869729000916 signature motif; other site 869729000917 putative triphosphate binding site [ion binding]; other site 869729000918 CHAD domain; Region: CHAD; pfam05235 869729000919 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 869729000920 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 869729000921 metal binding triad; other site 869729000922 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 869729000923 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 869729000924 metal binding triad; other site 869729000925 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 869729000926 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 869729000927 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 869729000928 putative ribose interaction site [chemical binding]; other site 869729000929 putative ADP binding site [chemical binding]; other site 869729000930 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 869729000931 active site 869729000932 nucleotide binding site [chemical binding]; other site 869729000933 HIGH motif; other site 869729000934 KMSKS motif; other site 869729000935 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 869729000936 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 869729000937 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 869729000938 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 869729000939 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 869729000940 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 869729000941 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 869729000942 Fimbrial protein; Region: Fimbrial; pfam00419 869729000943 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 869729000944 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 869729000945 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 869729000946 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 869729000947 PapC N-terminal domain; Region: PapC_N; pfam13954 869729000948 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 869729000949 PapC C-terminal domain; Region: PapC_C; pfam13953 869729000950 putative fimbrial protein; Provisional; Region: PRK09733 869729000951 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 869729000952 zinc transporter ZupT; Provisional; Region: PRK04201 869729000953 ZIP Zinc transporter; Region: Zip; pfam02535 869729000954 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 869729000955 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 869729000956 putative active site [active] 869729000957 metal binding site [ion binding]; metal-binding site 869729000958 putative disulfide oxidoreductase; Provisional; Region: PRK04307 869729000959 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 869729000960 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 869729000961 catalytic residues [active] 869729000962 hinge region; other site 869729000963 alpha helical domain; other site 869729000964 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 869729000965 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 869729000966 hypothetical protein; Provisional; Region: PRK11653 869729000967 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 869729000968 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 869729000969 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 869729000970 dimer interface [polypeptide binding]; other site 869729000971 ADP-ribose binding site [chemical binding]; other site 869729000972 active site 869729000973 nudix motif; other site 869729000974 metal binding site [ion binding]; metal-binding site 869729000975 putative dehydrogenase; Provisional; Region: PRK11039 869729000976 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 869729000977 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 869729000978 active site 869729000979 metal binding site [ion binding]; metal-binding site 869729000980 hexamer interface [polypeptide binding]; other site 869729000981 esterase YqiA; Provisional; Region: PRK11071 869729000982 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 869729000983 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 869729000984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729000985 ATP binding site [chemical binding]; other site 869729000986 Mg2+ binding site [ion binding]; other site 869729000987 G-X-G motif; other site 869729000988 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 869729000989 anchoring element; other site 869729000990 dimer interface [polypeptide binding]; other site 869729000991 ATP binding site [chemical binding]; other site 869729000992 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 869729000993 active site 869729000994 metal binding site [ion binding]; metal-binding site 869729000995 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 869729000996 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 869729000997 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 869729000998 N-terminal plug; other site 869729000999 ligand-binding site [chemical binding]; other site 869729001000 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 869729001001 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 869729001002 Walker A/P-loop; other site 869729001003 ATP binding site [chemical binding]; other site 869729001004 Q-loop/lid; other site 869729001005 ABC transporter signature motif; other site 869729001006 Walker B; other site 869729001007 D-loop; other site 869729001008 H-loop/switch region; other site 869729001009 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 869729001010 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869729001011 dimer interface [polypeptide binding]; other site 869729001012 putative PBP binding regions; other site 869729001013 ABC-ATPase subunit interface; other site 869729001014 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 869729001015 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869729001016 ABC-ATPase subunit interface; other site 869729001017 dimer interface [polypeptide binding]; other site 869729001018 putative PBP binding regions; other site 869729001019 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 869729001020 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 869729001021 siderophore binding site; other site 869729001022 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 869729001023 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 869729001024 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cd04795 869729001025 Uncharacterized conserved protein [Function unknown]; Region: COG1359 869729001026 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 869729001027 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 869729001028 sensor protein QseC; Provisional; Region: PRK10337 869729001029 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869729001030 dimer interface [polypeptide binding]; other site 869729001031 phosphorylation site [posttranslational modification] 869729001032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729001033 ATP binding site [chemical binding]; other site 869729001034 Mg2+ binding site [ion binding]; other site 869729001035 G-X-G motif; other site 869729001036 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 869729001037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729001038 active site 869729001039 phosphorylation site [posttranslational modification] 869729001040 intermolecular recognition site; other site 869729001041 dimerization interface [polypeptide binding]; other site 869729001042 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869729001043 DNA binding site [nucleotide binding] 869729001044 TIGR00156 family protein; Region: TIGR00156 869729001045 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 869729001046 putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755 869729001047 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 869729001048 peptide binding site [polypeptide binding]; other site 869729001049 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 869729001050 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 869729001051 CAP-like domain; other site 869729001052 active site 869729001053 primary dimer interface [polypeptide binding]; other site 869729001054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869729001055 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 869729001056 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 869729001057 putative acyl-acceptor binding pocket; other site 869729001058 FtsI repressor; Provisional; Region: PRK10883 869729001059 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 869729001060 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 869729001061 DctM-like transporters; Region: DctM; pfam06808 869729001062 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 869729001063 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 869729001064 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 869729001065 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 869729001066 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 869729001067 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 869729001068 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 869729001069 putative NAD(P) binding site [chemical binding]; other site 869729001070 catalytic Zn binding site [ion binding]; other site 869729001071 structural Zn binding site [ion binding]; other site 869729001072 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 869729001073 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 869729001074 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 869729001075 Transcriptional regulators [Transcription]; Region: FadR; COG2186 869729001076 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869729001077 DNA-binding site [nucleotide binding]; DNA binding site 869729001078 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 869729001079 hypothetical protein; Provisional; Region: PRK01254 869729001080 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 869729001081 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 869729001082 putative outer membrane lipoprotein; Provisional; Region: PRK09973 869729001083 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 869729001084 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 869729001085 active site 869729001086 catalytic tetrad [active] 869729001087 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 869729001088 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 869729001089 dimer interface [polypeptide binding]; other site 869729001090 active site 869729001091 metal binding site [ion binding]; metal-binding site 869729001092 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 869729001093 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 869729001094 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729001095 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729001096 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 869729001097 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 869729001098 cystathionine beta-lyase; Provisional; Region: PRK08114 869729001099 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 869729001100 homodimer interface [polypeptide binding]; other site 869729001101 substrate-cofactor binding pocket; other site 869729001102 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729001103 catalytic residue [active] 869729001104 biopolymer transport protein ExbB; Provisional; Region: PRK10414 869729001105 biopolymer transport protein ExbD; Provisional; Region: PRK11267 869729001106 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 869729001107 oxidoreductase; Provisional; Region: PRK07985 869729001108 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 869729001109 NAD binding site [chemical binding]; other site 869729001110 metal binding site [ion binding]; metal-binding site 869729001111 active site 869729001112 hypothetical protein; Provisional; Region: PRK05208 869729001113 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 869729001114 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 869729001115 active site 869729001116 catalytic tetrad [active] 869729001117 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 869729001118 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 869729001119 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 869729001120 hydrogenase 2 small subunit; Provisional; Region: PRK10468 869729001121 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 869729001122 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 869729001123 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 869729001124 4Fe-4S binding domain; Region: Fer4_6; pfam12837 869729001125 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 869729001126 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 869729001127 hydrogenase 2 large subunit; Provisional; Region: PRK10467 869729001128 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 869729001129 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 869729001130 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 869729001131 putative substrate-binding site; other site 869729001132 nickel binding site [ion binding]; other site 869729001133 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 869729001134 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 869729001135 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 869729001136 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 869729001137 putative S-transferase; Provisional; Region: PRK11752 869729001138 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 869729001139 C-terminal domain interface [polypeptide binding]; other site 869729001140 GSH binding site (G-site) [chemical binding]; other site 869729001141 dimer interface [polypeptide binding]; other site 869729001142 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 869729001143 dimer interface [polypeptide binding]; other site 869729001144 N-terminal domain interface [polypeptide binding]; other site 869729001145 active site 869729001146 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 869729001147 CHAP domain; Region: CHAP; pfam05257 869729001148 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 869729001149 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 869729001150 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 869729001151 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 869729001152 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 869729001153 TMP-binding site; other site 869729001154 ATP-binding site [chemical binding]; other site 869729001155 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 869729001156 TMP-binding site; other site 869729001157 ATP-binding site [chemical binding]; other site 869729001158 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 869729001159 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 869729001160 active site 869729001161 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 869729001162 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 869729001163 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 869729001164 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 869729001165 Predicted permeases [General function prediction only]; Region: COG0795 869729001166 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 869729001167 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 869729001168 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 869729001169 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869729001170 catalytic residue [active] 869729001171 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 869729001172 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 869729001173 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 869729001174 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869729001175 NAD(P) binding site [chemical binding]; other site 869729001176 active site 869729001177 acyl-CoA synthetase; Validated; Region: PRK09192 869729001178 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 869729001179 acyl-activating enzyme (AAE) consensus motif; other site 869729001180 active site 869729001181 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 869729001182 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869729001183 DNA-binding site [nucleotide binding]; DNA binding site 869729001184 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 869729001185 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 869729001186 FAD binding domain; Region: FAD_binding_4; pfam01565 869729001187 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 869729001188 FAD binding domain; Region: FAD_binding_4; pfam01565 869729001189 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 869729001190 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 869729001191 Cysteine-rich domain; Region: CCG; pfam02754 869729001192 Cysteine-rich domain; Region: CCG; pfam02754 869729001193 hypothetical protein; Provisional; Region: PRK09732 869729001194 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 869729001195 active site 869729001196 glycolate transporter; Provisional; Region: PRK09695 869729001197 L-lactate permease; Region: Lactate_perm; cl00701 869729001198 Domain of unknown function (DUF4092); Region: DUF4092; pfam13322 869729001199 Peptidase M60-like family; Region: M60-like; pfam13402 869729001200 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 869729001201 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 869729001202 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 869729001203 putative type II secretion protein GspC; Provisional; Region: PRK09681 869729001204 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 869729001205 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 869729001206 type II secretion system protein D; Region: type_II_gspD; TIGR02517 869729001207 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 869729001208 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 869729001209 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 869729001210 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 869729001211 type II secretion system protein E; Region: type_II_gspE; TIGR02533 869729001212 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 869729001213 Walker A motif; other site 869729001214 ATP binding site [chemical binding]; other site 869729001215 Walker B motif; other site 869729001216 type II secretion system protein F; Region: GspF; TIGR02120 869729001217 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 869729001218 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 869729001219 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 869729001220 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 869729001221 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 869729001222 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 869729001223 Type II transport protein GspH; Region: GspH; pfam12019 869729001224 type II secretion system protein I; Region: gspI; TIGR01707 869729001225 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 869729001226 type II secretion system protein J; Region: gspJ; TIGR01711 869729001227 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 869729001228 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 869729001229 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 869729001230 GspL-like protein; Provisional; Region: PRK09662 869729001231 putative general secretion pathway protein YghD; Provisional; Region: PRK09731 869729001232 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 869729001233 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869729001234 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 869729001235 Walker A/P-loop; other site 869729001236 ATP binding site [chemical binding]; other site 869729001237 Q-loop/lid; other site 869729001238 ABC transporter signature motif; other site 869729001239 Walker B; other site 869729001240 D-loop; other site 869729001241 H-loop/switch region; other site 869729001242 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 869729001243 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 869729001244 putative trimer interface [polypeptide binding]; other site 869729001245 putative CoA binding site [chemical binding]; other site 869729001246 potential frameshift: common BLAST hit: gi|218560025|ref|YP_002392938.1| N-acylneuraminate-9-phosphate synthase 869729001247 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 869729001248 ligand binding site; other site 869729001249 tetramer interface; other site 869729001250 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 869729001251 active site 869729001252 catalytic triad [active] 869729001253 oxyanion hole [active] 869729001254 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 869729001255 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 869729001256 active site 869729001257 homodimer interface [polypeptide binding]; other site 869729001258 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 869729001259 Alpha-2,8-polysialyltransferase (POLYST); Region: A-2_8-polyST; pfam07388 869729001260 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 869729001261 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 869729001262 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 869729001263 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 869729001264 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 869729001265 Ligand binding site; other site 869729001266 oligomer interface; other site 869729001267 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 869729001268 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 869729001269 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 869729001270 KpsF/GutQ family protein; Region: kpsF; TIGR00393 869729001271 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 869729001272 putative active site [active] 869729001273 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 869729001274 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 869729001275 ornithine decarboxylase; Provisional; Region: PRK13578 869729001276 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 869729001277 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 869729001278 homodimer interface [polypeptide binding]; other site 869729001279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729001280 catalytic residue [active] 869729001281 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 869729001282 nucleoside transporter; Region: 2A0110; TIGR00889 869729001283 murein transglycosylase C; Provisional; Region: mltC; PRK11671 869729001284 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 869729001285 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 869729001286 N-acetyl-D-glucosamine binding site [chemical binding]; other site 869729001287 catalytic residue [active] 869729001288 oxidative damage protection protein; Provisional; Region: PRK05408 869729001289 adenine DNA glycosylase; Provisional; Region: PRK10880 869729001290 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 869729001291 minor groove reading motif; other site 869729001292 helix-hairpin-helix signature motif; other site 869729001293 substrate binding pocket [chemical binding]; other site 869729001294 active site 869729001295 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 869729001296 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 869729001297 DNA binding and oxoG recognition site [nucleotide binding] 869729001298 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 869729001299 hypothetical protein; Provisional; Region: PRK11702 869729001300 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 869729001301 hypothetical protein; Provisional; Region: PRK10626 869729001302 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 869729001303 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 869729001304 homodimer interface [polypeptide binding]; other site 869729001305 active site 869729001306 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 869729001307 HemN family oxidoreductase; Provisional; Region: PRK05660 869729001308 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869729001309 FeS/SAM binding site; other site 869729001310 HemN C-terminal domain; Region: HemN_C; pfam06969 869729001311 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 869729001312 active site 869729001313 dimerization interface [polypeptide binding]; other site 869729001314 hypothetical protein; Validated; Region: PRK05090 869729001315 YGGT family; Region: YGGT; pfam02325 869729001316 YGGT family; Region: YGGT; pfam02325 869729001317 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 869729001318 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869729001319 catalytic residue [active] 869729001320 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 869729001321 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 869729001322 Walker A motif; other site 869729001323 ATP binding site [chemical binding]; other site 869729001324 Walker B motif; other site 869729001325 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 869729001326 hypothetical protein; Validated; Region: PRK00228 869729001327 glutathione synthetase; Provisional; Region: PRK05246 869729001328 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 869729001329 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 869729001330 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 869729001331 RNA methyltransferase, RsmE family; Region: TIGR00046 869729001332 DNA-specific endonuclease I; Provisional; Region: PRK15137 869729001333 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 869729001334 hypothetical protein; Provisional; Region: PRK04860 869729001335 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 869729001336 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 869729001337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729001338 putative substrate translocation pore; other site 869729001339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729001340 S-adenosylmethionine synthetase; Validated; Region: PRK05250 869729001341 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 869729001342 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 869729001343 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 869729001344 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 869729001345 Virulence promoting factor; Region: YqgB; pfam11036 869729001346 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 869729001347 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 869729001348 dimer interface [polypeptide binding]; other site 869729001349 active site 869729001350 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869729001351 catalytic residues [active] 869729001352 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 869729001353 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 869729001354 agmatinase; Region: agmatinase; TIGR01230 869729001355 oligomer interface [polypeptide binding]; other site 869729001356 putative active site [active] 869729001357 Mn binding site [ion binding]; other site 869729001358 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 869729001359 transketolase; Reviewed; Region: PRK12753 869729001360 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 869729001361 TPP-binding site [chemical binding]; other site 869729001362 dimer interface [polypeptide binding]; other site 869729001363 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 869729001364 PYR/PP interface [polypeptide binding]; other site 869729001365 dimer interface [polypeptide binding]; other site 869729001366 TPP binding site [chemical binding]; other site 869729001367 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869729001368 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 869729001369 SPFH domain / Band 7 family; Region: Band_7; pfam01145 869729001370 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869729001371 active site 869729001372 phosphorylation site [posttranslational modification] 869729001373 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 869729001374 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 869729001375 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 869729001376 active site 869729001377 P-loop; other site 869729001378 phosphorylation site [posttranslational modification] 869729001379 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 869729001380 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 869729001381 putative NAD(P) binding site [chemical binding]; other site 869729001382 catalytic Zn binding site [ion binding]; other site 869729001383 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 869729001384 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 869729001385 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 869729001386 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 869729001387 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 869729001388 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 869729001389 active site 869729001390 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 869729001391 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869729001392 Walker A/P-loop; other site 869729001393 ATP binding site [chemical binding]; other site 869729001394 Q-loop/lid; other site 869729001395 ABC transporter signature motif; other site 869729001396 Walker B; other site 869729001397 D-loop; other site 869729001398 H-loop/switch region; other site 869729001399 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 869729001400 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869729001401 Walker A/P-loop; other site 869729001402 ATP binding site [chemical binding]; other site 869729001403 Q-loop/lid; other site 869729001404 ABC transporter signature motif; other site 869729001405 Walker B; other site 869729001406 D-loop; other site 869729001407 H-loop/switch region; other site 869729001408 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 869729001409 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 869729001410 trimer interface [polypeptide binding]; other site 869729001411 putative Zn binding site [ion binding]; other site 869729001412 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 869729001413 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 869729001414 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 869729001415 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 869729001416 Phosphoglycerate kinase; Region: PGK; pfam00162 869729001417 substrate binding site [chemical binding]; other site 869729001418 hinge regions; other site 869729001419 ADP binding site [chemical binding]; other site 869729001420 catalytic site [active] 869729001421 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 869729001422 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 869729001423 active site 869729001424 intersubunit interface [polypeptide binding]; other site 869729001425 zinc binding site [ion binding]; other site 869729001426 Na+ binding site [ion binding]; other site 869729001427 mechanosensitive channel MscS; Provisional; Region: PRK10334 869729001428 Mechanosensitive ion channel; Region: MS_channel; pfam00924 869729001429 arginine exporter protein; Provisional; Region: PRK09304 869729001430 Uncharacterized conserved protein [Function unknown]; Region: COG2968 869729001431 oxidative stress defense protein; Provisional; Region: PRK11087 869729001432 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729001433 Transcriptional regulator [Transcription]; Region: LysR; COG0583 869729001434 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 869729001435 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 869729001436 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729001437 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 869729001438 putative dimerization interface [polypeptide binding]; other site 869729001439 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 869729001440 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 869729001441 tetramer (dimer of dimers) interface [polypeptide binding]; other site 869729001442 active site 869729001443 dimer interface [polypeptide binding]; other site 869729001444 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 869729001445 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 869729001446 ligand binding site [chemical binding]; other site 869729001447 NAD binding site [chemical binding]; other site 869729001448 tetramer interface [polypeptide binding]; other site 869729001449 catalytic site [active] 869729001450 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 869729001451 L-serine binding site [chemical binding]; other site 869729001452 ACT domain interface; other site 869729001453 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 869729001454 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 869729001455 Z-ring-associated protein; Provisional; Region: PRK10972 869729001456 hypothetical protein; Reviewed; Region: PRK01736 869729001457 proline aminopeptidase P II; Provisional; Region: PRK10879 869729001458 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 869729001459 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 869729001460 active site 869729001461 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 869729001462 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 869729001463 oxidoreductase; Provisional; Region: PRK08013 869729001464 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 869729001465 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 869729001466 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 869729001467 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 869729001468 lipoyl attachment site [posttranslational modification]; other site 869729001469 glycine dehydrogenase; Provisional; Region: PRK05367 869729001470 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 869729001471 tetramer interface [polypeptide binding]; other site 869729001472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729001473 catalytic residue [active] 869729001474 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 869729001475 tetramer interface [polypeptide binding]; other site 869729001476 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729001477 catalytic residue [active] 869729001478 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 869729001479 beta-galactosidase; Region: BGL; TIGR03356 869729001480 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 869729001481 hemolysin; Provisional; Region: PRK15087 869729001482 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 869729001483 putative global regulator; Reviewed; Region: PRK09559 869729001484 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 869729001485 hypothetical protein; Provisional; Region: PRK10878 869729001486 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 869729001487 flavodoxin FldB; Provisional; Region: PRK12359 869729001488 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 869729001489 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 869729001490 active site 869729001491 Int/Topo IB signature motif; other site 869729001492 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 869729001493 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 869729001494 dimerization domain [polypeptide binding]; other site 869729001495 dimer interface [polypeptide binding]; other site 869729001496 catalytic residues [active] 869729001497 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 869729001498 DHH family; Region: DHH; pfam01368 869729001499 DHHA1 domain; Region: DHHA1; pfam02272 869729001500 peptide chain release factor 2; Provisional; Region: PRK08787 869729001501 This domain is found in peptide chain release factors; Region: PCRF; smart00937 869729001502 RF-1 domain; Region: RF-1; pfam00472 869729001503 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 869729001504 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 869729001505 dimer interface [polypeptide binding]; other site 869729001506 putative anticodon binding site; other site 869729001507 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 869729001508 motif 1; other site 869729001509 active site 869729001510 motif 2; other site 869729001511 motif 3; other site 869729001512 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 869729001513 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 869729001514 active site 869729001515 metal binding site [ion binding]; metal-binding site 869729001516 nudix motif; other site 869729001517 xanthine permease; Region: pbuX; TIGR03173 869729001518 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 869729001519 4Fe-4S binding domain; Region: Fer4; pfam00037 869729001520 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 869729001521 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869729001522 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 869729001523 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 869729001524 guanine deaminase; Provisional; Region: PRK09228 869729001525 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 869729001526 active site 869729001527 uracil-xanthine permease; Region: ncs2; TIGR00801 869729001528 putative hypoxanthine oxidase; Provisional; Region: PRK09800 869729001529 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 869729001530 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 869729001531 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 869729001532 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 869729001533 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 869729001534 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 869729001535 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 869729001536 active site 869729001537 putative substrate binding pocket [chemical binding]; other site 869729001538 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 869729001539 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 869729001540 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869729001541 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 869729001542 Ligand binding site; other site 869729001543 metal-binding site 869729001544 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 869729001545 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 869729001546 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 869729001547 XdhC Rossmann domain; Region: XdhC_C; pfam13478 869729001548 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 869729001549 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 869729001550 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 869729001551 carbamate kinase; Reviewed; Region: PRK12686 869729001552 putative substrate binding site [chemical binding]; other site 869729001553 homodimer interface [polypeptide binding]; other site 869729001554 nucleotide binding site [chemical binding]; other site 869729001555 nucleotide binding site [chemical binding]; other site 869729001556 D-hydantoinase; Region: D-hydantoinase; TIGR02033 869729001557 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 869729001558 tetramer interface [polypeptide binding]; other site 869729001559 active site 869729001560 peptidase; Reviewed; Region: PRK13004 869729001561 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 869729001562 putative metal binding site [ion binding]; other site 869729001563 putative dimer interface [polypeptide binding]; other site 869729001564 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 869729001565 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 869729001566 catalytic residue [active] 869729001567 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 869729001568 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 869729001569 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 869729001570 GAF domain; Region: GAF; cl17456 869729001571 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 869729001572 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869729001573 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729001574 Walker A motif; other site 869729001575 ATP binding site [chemical binding]; other site 869729001576 Walker B motif; other site 869729001577 arginine finger; other site 869729001578 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 869729001579 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 869729001580 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 869729001581 catalytic loop [active] 869729001582 iron binding site [ion binding]; other site 869729001583 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 869729001584 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 869729001585 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 869729001586 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 869729001587 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 869729001588 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 869729001589 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869729001590 Peptidase family M23; Region: Peptidase_M23; pfam01551 869729001591 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 869729001592 serine transporter; Region: stp; TIGR00814 869729001593 putative acyltransferase; Provisional; Region: PRK05790 869729001594 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 869729001595 dimer interface [polypeptide binding]; other site 869729001596 active site 869729001597 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 869729001598 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 869729001599 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 869729001600 NADP binding site [chemical binding]; other site 869729001601 homodimer interface [polypeptide binding]; other site 869729001602 active site 869729001603 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 869729001604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729001605 putative substrate translocation pore; other site 869729001606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729001607 putative racemase; Provisional; Region: PRK10200 869729001608 aspartate racemase; Region: asp_race; TIGR00035 869729001609 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 869729001610 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729001611 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 869729001612 dimerization interface [polypeptide binding]; other site 869729001613 diaminopimelate decarboxylase; Provisional; Region: PRK11165 869729001614 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 869729001615 active site 869729001616 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869729001617 substrate binding site [chemical binding]; other site 869729001618 catalytic residues [active] 869729001619 dimer interface [polypeptide binding]; other site 869729001620 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 869729001621 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869729001622 DNA binding site [nucleotide binding] 869729001623 domain linker motif; other site 869729001624 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 869729001625 dimerization interface (closed form) [polypeptide binding]; other site 869729001626 ligand binding site [chemical binding]; other site 869729001627 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 869729001628 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 869729001629 putative acyl-acceptor binding pocket; other site 869729001630 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 869729001631 acyl-activating enzyme (AAE) consensus motif; other site 869729001632 putative AMP binding site [chemical binding]; other site 869729001633 lysophospholipid transporter LplT; Provisional; Region: PRK11195 869729001634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729001635 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 869729001636 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 869729001637 active site 869729001638 catalytic tetrad [active] 869729001639 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 869729001640 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 869729001641 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 869729001642 putative DNA-binding cleft [nucleotide binding]; other site 869729001643 putative DNA clevage site; other site 869729001644 molecular lever; other site 869729001645 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 869729001646 putative active site [active] 869729001647 Ap4A binding site [chemical binding]; other site 869729001648 nudix motif; other site 869729001649 putative metal binding site [ion binding]; other site 869729001650 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 869729001651 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 869729001652 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 869729001653 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 869729001654 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 869729001655 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 869729001656 thymidylate synthase; Reviewed; Region: thyA; PRK01827 869729001657 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 869729001658 dimerization interface [polypeptide binding]; other site 869729001659 active site 869729001660 hypothetical protein; Provisional; Region: PRK10506 869729001661 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 869729001662 hypothetical protein; Provisional; Region: PRK10557 869729001663 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 869729001664 hypothetical protein; Provisional; Region: PRK11521 869729001665 hypothetical protein; Provisional; Region: PRK10332 869729001666 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 869729001667 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 869729001668 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 869729001669 protease3; Provisional; Region: PRK15101 869729001670 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 869729001671 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 869729001672 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 869729001673 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 869729001674 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 869729001675 AAA domain; Region: AAA_30; pfam13604 869729001676 Family description; Region: UvrD_C_2; pfam13538 869729001677 N-acetylglutamate synthase; Validated; Region: PRK05279 869729001678 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 869729001679 putative feedback inhibition sensing region; other site 869729001680 putative nucleotide binding site [chemical binding]; other site 869729001681 putative substrate binding site [chemical binding]; other site 869729001682 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869729001683 Coenzyme A binding pocket [chemical binding]; other site 869729001684 AMIN domain; Region: AMIN; pfam11741 869729001685 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 869729001686 active site 869729001687 metal binding site [ion binding]; metal-binding site 869729001688 potential frameshift: common BLAST hit: gi|218690942|ref|YP_002399154.1| putative transcription antiterminator 869729001689 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 869729001690 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869729001691 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869729001692 active site turn [active] 869729001693 phosphorylation site [posttranslational modification] 869729001694 potential frameshift: common BLAST hit: gi|218559826|ref|YP_002392739.1| putative aminotransferase 869729001695 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 869729001696 putative active site [active] 869729001697 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 869729001698 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 869729001699 putative ligand binding site [chemical binding]; other site 869729001700 putative NAD binding site [chemical binding]; other site 869729001701 catalytic site [active] 869729001702 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 869729001703 ImpA domain protein; Region: DUF3702; pfam12486 869729001704 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 869729001705 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 869729001706 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 869729001707 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 869729001708 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 869729001709 PAAR motif; Region: PAAR_motif; pfam05488 869729001710 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 869729001711 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 869729001712 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 869729001713 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 869729001714 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 869729001715 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 869729001716 PAAR motif; Region: PAAR_motif; pfam05488 869729001717 PGAP1-like protein; Region: PGAP1; pfam07819 869729001718 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 869729001719 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 869729001720 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 869729001721 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 869729001722 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 869729001723 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 869729001724 Clp amino terminal domain; Region: Clp_N; pfam02861 869729001725 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729001726 Walker A motif; other site 869729001727 ATP binding site [chemical binding]; other site 869729001728 Walker B motif; other site 869729001729 arginine finger; other site 869729001730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729001731 Walker A motif; other site 869729001732 ATP binding site [chemical binding]; other site 869729001733 Walker B motif; other site 869729001734 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 869729001735 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 869729001736 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 869729001737 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 869729001738 ligand binding site [chemical binding]; other site 869729001739 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 869729001740 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 869729001741 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 869729001742 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 869729001743 Protein of unknown function (DUF877); Region: DUF877; pfam05943 869729001744 Protein of unknown function (DUF770); Region: DUF770; pfam05591 869729001745 murein transglycosylase A; Provisional; Region: mltA; PRK11162 869729001746 MltA specific insert domain; Region: MltA; pfam03562 869729001747 3D domain; Region: 3D; pfam06725 869729001748 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 869729001749 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 869729001750 putative ATP binding site [chemical binding]; other site 869729001751 putative substrate interface [chemical binding]; other site 869729001752 CsdA-binding activator; Provisional; Region: PRK15019 869729001753 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 869729001754 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 869729001755 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869729001756 catalytic residue [active] 869729001757 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 869729001758 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 869729001759 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729001760 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 869729001761 dimerization interface [polypeptide binding]; other site 869729001762 substrate binding pocket [chemical binding]; other site 869729001763 hypothetical protein; Provisional; Region: PRK10873 869729001764 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 869729001765 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 869729001766 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 869729001767 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 869729001768 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869729001769 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 869729001770 L-fuculokinase; Provisional; Region: PRK10331 869729001771 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 869729001772 nucleotide binding site [chemical binding]; other site 869729001773 L-fucose isomerase; Provisional; Region: fucI; PRK10991 869729001774 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 869729001775 hexamer (dimer of trimers) interface [polypeptide binding]; other site 869729001776 trimer interface [polypeptide binding]; other site 869729001777 substrate binding site [chemical binding]; other site 869729001778 Mn binding site [ion binding]; other site 869729001779 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 869729001780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729001781 putative substrate translocation pore; other site 869729001782 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 869729001783 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 869729001784 intersubunit interface [polypeptide binding]; other site 869729001785 active site 869729001786 Zn2+ binding site [ion binding]; other site 869729001787 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 869729001788 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 869729001789 dimer interface [polypeptide binding]; other site 869729001790 active site 869729001791 metal binding site [ion binding]; metal-binding site 869729001792 flap endonuclease-like protein; Provisional; Region: PRK09482 869729001793 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 869729001794 active site 869729001795 metal binding site 1 [ion binding]; metal-binding site 869729001796 putative 5' ssDNA interaction site; other site 869729001797 metal binding site 3; metal-binding site 869729001798 metal binding site 2 [ion binding]; metal-binding site 869729001799 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 869729001800 putative DNA binding site [nucleotide binding]; other site 869729001801 putative metal binding site [ion binding]; other site 869729001802 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 869729001803 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 869729001804 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 869729001805 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 869729001806 serine transporter; Region: stp; TIGR00814 869729001807 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 869729001808 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 869729001809 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 869729001810 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 869729001811 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 869729001812 SecY interacting protein Syd; Provisional; Region: PRK04968 869729001813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 869729001814 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 869729001815 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 869729001816 probable active site [active] 869729001817 flavodoxin; Provisional; Region: PRK08105 869729001818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729001819 D-galactonate transporter; Region: 2A0114; TIGR00893 869729001820 putative substrate translocation pore; other site 869729001821 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 869729001822 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 869729001823 active site 869729001824 tetramer interface [polypeptide binding]; other site 869729001825 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 869729001826 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 869729001827 active site 869729001828 tetramer interface [polypeptide binding]; other site 869729001829 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 869729001830 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 869729001831 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869729001832 dimerization interface [polypeptide binding]; other site 869729001833 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869729001834 dimer interface [polypeptide binding]; other site 869729001835 phosphorylation site [posttranslational modification] 869729001836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729001837 ATP binding site [chemical binding]; other site 869729001838 Mg2+ binding site [ion binding]; other site 869729001839 G-X-G motif; other site 869729001840 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 869729001841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729001842 active site 869729001843 phosphorylation site [posttranslational modification] 869729001844 intermolecular recognition site; other site 869729001845 dimerization interface [polypeptide binding]; other site 869729001846 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 869729001847 putative binding surface; other site 869729001848 active site 869729001849 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 869729001850 TRAM domain; Region: TRAM; pfam01938 869729001851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729001852 S-adenosylmethionine binding site [chemical binding]; other site 869729001853 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 869729001854 HD domain; Region: HD_4; pfam13328 869729001855 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 869729001856 synthetase active site [active] 869729001857 NTP binding site [chemical binding]; other site 869729001858 metal binding site [ion binding]; metal-binding site 869729001859 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 869729001860 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 869729001861 antitoxin MazE; Provisional; Region: PRK09798 869729001862 toxin MazF; Provisional; Region: PRK09907 869729001863 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 869729001864 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 869729001865 homodimer interface [polypeptide binding]; other site 869729001866 metal binding site [ion binding]; metal-binding site 869729001867 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 869729001868 homodimer interface [polypeptide binding]; other site 869729001869 active site 869729001870 putative chemical substrate binding site [chemical binding]; other site 869729001871 metal binding site [ion binding]; metal-binding site 869729001872 CTP synthetase; Validated; Region: pyrG; PRK05380 869729001873 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 869729001874 Catalytic site [active] 869729001875 active site 869729001876 UTP binding site [chemical binding]; other site 869729001877 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 869729001878 active site 869729001879 putative oxyanion hole; other site 869729001880 catalytic triad [active] 869729001881 enolase; Provisional; Region: eno; PRK00077 869729001882 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 869729001883 dimer interface [polypeptide binding]; other site 869729001884 metal binding site [ion binding]; metal-binding site 869729001885 substrate binding pocket [chemical binding]; other site 869729001886 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 869729001887 Repair protein; Region: Repair_PSII; pfam04536 869729001888 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 869729001889 Repair protein; Region: Repair_PSII; pfam04536 869729001890 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 869729001891 Repair protein; Region: Repair_PSII; pfam04536 869729001892 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 869729001893 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 869729001894 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 869729001895 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 869729001896 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 869729001897 nucleotide binding site [chemical binding]; other site 869729001898 potential frameshift: common BLAST hit: gi|218690894|ref|YP_002399106.1| putative transporter 869729001899 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 869729001900 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 869729001901 NADP binding site [chemical binding]; other site 869729001902 homodimer interface [polypeptide binding]; other site 869729001903 active site 869729001904 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 869729001905 FAD binding domain; Region: FAD_binding_4; pfam01565 869729001906 benzoate transport; Region: 2A0115; TIGR00895 869729001907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729001908 putative substrate translocation pore; other site 869729001909 potential frameshift: common BLAST hit: gi|117624997|ref|YP_853985.1| putative electron transfer flavoprotein subunit YgcR 869729001910 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 869729001911 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 869729001912 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 869729001913 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 869729001914 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 869729001915 putative oxidoreductase FixC; Provisional; Region: PRK10157 869729001916 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 869729001917 active site 869729001918 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 869729001919 Flavodoxin; Region: Flavodoxin_1; pfam00258 869729001920 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 869729001921 FAD binding pocket [chemical binding]; other site 869729001922 FAD binding motif [chemical binding]; other site 869729001923 catalytic residues [active] 869729001924 NAD binding pocket [chemical binding]; other site 869729001925 phosphate binding motif [ion binding]; other site 869729001926 beta-alpha-beta structure motif; other site 869729001927 sulfite reductase subunit beta; Provisional; Region: PRK13504 869729001928 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 869729001929 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 869729001930 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 869729001931 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 869729001932 Active Sites [active] 869729001933 Hok/gef family; Region: HOK_GEF; pfam01848 869729001934 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 869729001935 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 869729001936 metal binding site [ion binding]; metal-binding site 869729001937 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 869729001938 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 869729001939 Active Sites [active] 869729001940 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 869729001941 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 869729001942 CysD dimerization site [polypeptide binding]; other site 869729001943 G1 box; other site 869729001944 putative GEF interaction site [polypeptide binding]; other site 869729001945 GTP/Mg2+ binding site [chemical binding]; other site 869729001946 Switch I region; other site 869729001947 G2 box; other site 869729001948 G3 box; other site 869729001949 Switch II region; other site 869729001950 G4 box; other site 869729001951 G5 box; other site 869729001952 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 869729001953 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 869729001954 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 869729001955 ligand-binding site [chemical binding]; other site 869729001956 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 869729001957 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 869729001958 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 869729001959 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 869729001960 substrate binding site; other site 869729001961 dimer interface; other site 869729001962 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 869729001963 homotrimer interaction site [polypeptide binding]; other site 869729001964 zinc binding site [ion binding]; other site 869729001965 CDP-binding sites; other site 869729001966 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 869729001967 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 869729001968 Permutation of conserved domain; other site 869729001969 active site 869729001970 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 869729001971 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 869729001972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729001973 S-adenosylmethionine binding site [chemical binding]; other site 869729001974 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 869729001975 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869729001976 Peptidase family M23; Region: Peptidase_M23; pfam01551 869729001977 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 869729001978 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 869729001979 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 869729001980 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 869729001981 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 869729001982 DNA binding residues [nucleotide binding] 869729001983 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 869729001984 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 869729001985 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 869729001986 putative transporter; Provisional; Region: PRK09821 869729001987 GntP family permease; Region: GntP_permease; pfam02447 869729001988 hypothetical protein; Provisional; Region: PRK09989 869729001989 putative aldolase; Validated; Region: PRK08130 869729001990 active site 869729001991 intersubunit interface [polypeptide binding]; other site 869729001992 Zn2+ binding site [ion binding]; other site 869729001993 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 869729001994 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 869729001995 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 869729001996 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 869729001997 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 869729001998 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869729001999 serine/threonine-specific protein phosphatase 2; Provisional; Region: PRK09968 869729002000 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 869729002001 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 869729002002 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 869729002003 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 869729002004 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 869729002005 MutS domain I; Region: MutS_I; pfam01624 869729002006 MutS domain II; Region: MutS_II; pfam05188 869729002007 MutS domain III; Region: MutS_III; pfam05192 869729002008 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 869729002009 Walker A/P-loop; other site 869729002010 ATP binding site [chemical binding]; other site 869729002011 Q-loop/lid; other site 869729002012 ABC transporter signature motif; other site 869729002013 Walker B; other site 869729002014 D-loop; other site 869729002015 H-loop/switch region; other site 869729002016 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 869729002017 molybdenum-pterin binding domain; Region: Mop; TIGR00638 869729002018 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 869729002019 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 869729002020 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 869729002021 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 869729002022 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729002023 Walker A motif; other site 869729002024 ATP binding site [chemical binding]; other site 869729002025 Walker B motif; other site 869729002026 arginine finger; other site 869729002027 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 869729002028 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 869729002029 dimerization interface [polypeptide binding]; other site 869729002030 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 869729002031 ATP binding site [chemical binding]; other site 869729002032 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 869729002033 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 869729002034 hydrogenase assembly chaperone; Provisional; Region: PRK10409 869729002035 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 869729002036 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 869729002037 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 869729002038 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 869729002039 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 869729002040 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 869729002041 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 869729002042 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 869729002043 NADH dehydrogenase; Region: NADHdh; cl00469 869729002044 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 869729002045 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 869729002046 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 869729002047 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 869729002048 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 869729002049 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 869729002050 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 869729002051 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 869729002052 nickel binding site [ion binding]; other site 869729002053 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869729002054 non-specific DNA binding site [nucleotide binding]; other site 869729002055 salt bridge; other site 869729002056 sequence-specific DNA binding site [nucleotide binding]; other site 869729002057 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 869729002058 beta-galactosidase; Region: BGL; TIGR03356 869729002059 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 869729002060 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869729002061 active site turn [active] 869729002062 phosphorylation site [posttranslational modification] 869729002063 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 869729002064 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869729002065 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869729002066 DNA binding site [nucleotide binding] 869729002067 domain linker motif; other site 869729002068 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 869729002069 dimerization interface (closed form) [polypeptide binding]; other site 869729002070 ligand binding site [chemical binding]; other site 869729002071 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 869729002072 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 869729002073 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 869729002074 Acylphosphatase; Region: Acylphosphatase; pfam00708 869729002075 HypF finger; Region: zf-HYPF; pfam07503 869729002076 HypF finger; Region: zf-HYPF; pfam07503 869729002077 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 869729002078 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 869729002079 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869729002080 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869729002081 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 869729002082 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 869729002083 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 869729002084 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 869729002085 iron binding site [ion binding]; other site 869729002086 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 869729002087 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 869729002088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729002089 Walker A motif; other site 869729002090 ATP binding site [chemical binding]; other site 869729002091 Walker B motif; other site 869729002092 arginine finger; other site 869729002093 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 869729002094 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 869729002095 putative active site [active] 869729002096 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 869729002097 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 869729002098 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 869729002099 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869729002100 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 869729002101 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 869729002102 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 869729002103 putative NAD(P) binding site [chemical binding]; other site 869729002104 active site 869729002105 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 869729002106 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 869729002107 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 869729002108 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 869729002109 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 869729002110 Transglycosylase SLT domain; Region: SLT_2; pfam13406 869729002111 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 869729002112 N-acetyl-D-glucosamine binding site [chemical binding]; other site 869729002113 hypothetical protein; Validated; Region: PRK03661 869729002114 recombinase A; Provisional; Region: recA; PRK09354 869729002115 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 869729002116 hexamer interface [polypeptide binding]; other site 869729002117 Walker A motif; other site 869729002118 ATP binding site [chemical binding]; other site 869729002119 Walker B motif; other site 869729002120 recombination regulator RecX; Reviewed; Region: recX; PRK00117 869729002121 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 869729002122 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 869729002123 motif 1; other site 869729002124 active site 869729002125 motif 2; other site 869729002126 motif 3; other site 869729002127 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 869729002128 DHHA1 domain; Region: DHHA1; pfam02272 869729002129 carbon storage regulator; Provisional; Region: PRK01712 869729002130 potential protein location (hypothetical protein UM146_03120 [Escherichia coli UM146]) that overlaps RNA (tRNA-R) 869729002131 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 869729002132 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869729002133 motif II; other site 869729002134 Predicted membrane protein [Function unknown]; Region: COG1238 869729002135 glutamate--cysteine ligase; Provisional; Region: PRK02107 869729002136 S-ribosylhomocysteinase; Provisional; Region: PRK02260 869729002137 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869729002138 Zn2+ binding site [ion binding]; other site 869729002139 Mg2+ binding site [ion binding]; other site 869729002140 AAA domain; Region: AAA_33; pfam13671 869729002141 RNA ligase; Region: RNA_ligase; pfam09414 869729002142 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 869729002143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729002144 putative substrate translocation pore; other site 869729002145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729002146 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 869729002147 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 869729002148 HlyD family secretion protein; Region: HlyD_3; pfam13437 869729002149 transcriptional repressor MprA; Provisional; Region: PRK10870 869729002150 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 869729002151 putative L-valine exporter; Provisional; Region: PRK10408 869729002152 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 869729002153 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 869729002154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729002155 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 869729002156 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 869729002157 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 869729002158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729002159 dimer interface [polypeptide binding]; other site 869729002160 conserved gate region; other site 869729002161 putative PBP binding loops; other site 869729002162 ABC-ATPase subunit interface; other site 869729002163 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 869729002164 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 869729002165 Walker A/P-loop; other site 869729002166 ATP binding site [chemical binding]; other site 869729002167 Q-loop/lid; other site 869729002168 ABC transporter signature motif; other site 869729002169 Walker B; other site 869729002170 D-loop; other site 869729002171 H-loop/switch region; other site 869729002172 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 869729002173 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 869729002174 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 869729002175 dimer interface [polypeptide binding]; other site 869729002176 putative radical transfer pathway; other site 869729002177 diiron center [ion binding]; other site 869729002178 tyrosyl radical; other site 869729002179 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 869729002180 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 869729002181 Class I ribonucleotide reductase; Region: RNR_I; cd01679 869729002182 active site 869729002183 dimer interface [polypeptide binding]; other site 869729002184 catalytic residues [active] 869729002185 effector binding site; other site 869729002186 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 869729002187 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 869729002188 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 869729002189 catalytic residues [active] 869729002190 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 869729002191 Uncharacterized conserved protein [Function unknown]; Region: COG2128 869729002192 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 869729002193 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869729002194 DNA-binding site [nucleotide binding]; DNA binding site 869729002195 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869729002196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729002197 homodimer interface [polypeptide binding]; other site 869729002198 catalytic residue [active] 869729002199 hypothetical protein; Provisional; Region: PRK10132 869729002200 hypothetical protein; Provisional; Region: PRK10556 869729002201 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 869729002202 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 869729002203 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 869729002204 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 869729002205 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869729002206 dimerization interface [polypeptide binding]; other site 869729002207 putative DNA binding site [nucleotide binding]; other site 869729002208 Transcriptional regulators [Transcription]; Region: MarR; COG1846 869729002209 putative Zn2+ binding site [ion binding]; other site 869729002210 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 869729002211 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 869729002212 bacterial OsmY and nodulation domain; Region: BON; smart00749 869729002213 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869729002214 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 869729002215 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869729002216 DNA-binding site [nucleotide binding]; DNA binding site 869729002217 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 869729002218 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 869729002219 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 869729002220 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 869729002221 inhibitor-cofactor binding pocket; inhibition site 869729002222 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729002223 catalytic residue [active] 869729002224 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 869729002225 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 869729002226 tetramerization interface [polypeptide binding]; other site 869729002227 NAD(P) binding site [chemical binding]; other site 869729002228 catalytic residues [active] 869729002229 Predicted dehydrogenase [General function prediction only]; Region: COG0579 869729002230 hydroxyglutarate oxidase; Provisional; Region: PRK11728 869729002231 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 869729002232 substrate binding pocket [chemical binding]; other site 869729002233 active site 869729002234 iron coordination sites [ion binding]; other site 869729002235 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 869729002236 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 869729002237 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 869729002238 Int/Topo IB signature motif; other site 869729002239 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 869729002240 Uncharacterized conserved protein [Function unknown]; Region: COG5532 869729002241 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 869729002242 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 869729002243 Catalytic site [active] 869729002244 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 869729002245 potential frameshift: common BLAST hit: gi|218559632|ref|YP_002392545.1| putative phage replication protein O 869729002246 PerC transcriptional activator; Region: PerC; pfam06069 869729002247 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 869729002248 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 869729002249 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 869729002250 KilA-N domain; Region: KilA-N; pfam04383 869729002251 Protein of unknown function (DUF968); Region: DUF968; pfam06147 869729002252 Antitermination protein; Region: Antiterm; pfam03589 869729002253 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 869729002254 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 869729002255 Zn binding sites [ion binding]; other site 869729002256 Antitermination protein; Region: Antiterm; pfam03589 869729002257 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 869729002258 N-acetyl-D-glucosamine binding site [chemical binding]; other site 869729002259 catalytic residue [active] 869729002260 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 869729002261 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 869729002262 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 869729002263 active site 869729002264 potential frameshift: common BLAST hit: gi|218559617|ref|YP_002392530.1| putative phage terminase, small subunit 869729002265 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 869729002266 Phage-related protein [Function unknown]; Region: COG4695 869729002267 Phage portal protein; Region: Phage_portal; pfam04860 869729002268 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 869729002269 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 869729002270 Phage capsid family; Region: Phage_capsid; pfam05065 869729002271 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 869729002272 oligomerization interface [polypeptide binding]; other site 869729002273 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 869729002274 Protein of unknown function (DUF2635); Region: DUF2635; pfam10948 869729002275 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 869729002276 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 869729002277 Phage tail tube protein; Region: Tail_tube; pfam10618 869729002278 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 869729002279 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 869729002280 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 869729002281 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 869729002282 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 869729002283 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 869729002284 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 869729002285 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; pfam06890 869729002286 Phage protein GP46; Region: GP46; pfam07409 869729002287 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 869729002288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3778 869729002289 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 869729002290 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 869729002291 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 869729002292 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 869729002293 catalytic nucleophile [active] 869729002294 Uncharacterized conserved protein [Function unknown]; Region: COG1479 869729002295 Protein of unknown function DUF262; Region: DUF262; pfam03235 869729002296 Protein of unknown function DUF262; Region: DUF262; pfam03235 869729002297 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 869729002298 DinI-like family; Region: DinI; cl11630 869729002299 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 869729002300 GIY-YIG motif/motif A; other site 869729002301 putative active site [active] 869729002302 putative metal binding site [ion binding]; other site 869729002303 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 869729002304 SmpB-tmRNA interface; other site 869729002305 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 869729002306 putative coenzyme Q binding site [chemical binding]; other site 869729002307 hypothetical protein; Validated; Region: PRK01777 869729002308 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 869729002309 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 869729002310 recombination and repair protein; Provisional; Region: PRK10869 869729002311 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 869729002312 Walker A/P-loop; other site 869729002313 ATP binding site [chemical binding]; other site 869729002314 Q-loop/lid; other site 869729002315 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 869729002316 Q-loop/lid; other site 869729002317 ABC transporter signature motif; other site 869729002318 Walker B; other site 869729002319 D-loop; other site 869729002320 H-loop/switch region; other site 869729002321 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 869729002322 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 869729002323 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 869729002324 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 869729002325 dimer interface [polypeptide binding]; other site 869729002326 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 869729002327 hypothetical protein; Provisional; Region: PRK11573 869729002328 Domain of unknown function DUF21; Region: DUF21; pfam01595 869729002329 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 869729002330 Transporter associated domain; Region: CorC_HlyC; smart01091 869729002331 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 869729002332 signal recognition particle protein; Provisional; Region: PRK10867 869729002333 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 869729002334 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 869729002335 P loop; other site 869729002336 GTP binding site [chemical binding]; other site 869729002337 Signal peptide binding domain; Region: SRP_SPB; pfam02978 869729002338 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 869729002339 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 869729002340 RimM N-terminal domain; Region: RimM; pfam01782 869729002341 PRC-barrel domain; Region: PRC; pfam05239 869729002342 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 869729002343 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 869729002344 putative outer membrane lipoprotein; Provisional; Region: PRK09967 869729002345 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 869729002346 ligand binding site [chemical binding]; other site 869729002347 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 869729002348 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 869729002349 metal binding site [ion binding]; metal-binding site 869729002350 active site 869729002351 I-site; other site 869729002352 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 869729002353 lipoprotein; Provisional; Region: PRK11443 869729002354 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 869729002355 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 869729002356 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 869729002357 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 869729002358 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 869729002359 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 869729002360 prephenate dehydrogenase; Validated; Region: PRK08507 869729002361 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 869729002362 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 869729002363 Prephenate dehydratase; Region: PDT; pfam00800 869729002364 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 869729002365 putative L-Phe binding site [chemical binding]; other site 869729002366 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 869729002367 30S subunit binding site; other site 869729002368 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 869729002369 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 869729002370 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 869729002371 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869729002372 RNA binding surface [nucleotide binding]; other site 869729002373 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 869729002374 active site 869729002375 hypothetical protein; Provisional; Region: PRK10723 869729002376 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 869729002377 protein disaggregation chaperone; Provisional; Region: PRK10865 869729002378 Clp amino terminal domain; Region: Clp_N; pfam02861 869729002379 Clp amino terminal domain; Region: Clp_N; pfam02861 869729002380 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729002381 Walker A motif; other site 869729002382 ATP binding site [chemical binding]; other site 869729002383 Walker B motif; other site 869729002384 arginine finger; other site 869729002385 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729002386 Walker A motif; other site 869729002387 ATP binding site [chemical binding]; other site 869729002388 Walker B motif; other site 869729002389 arginine finger; other site 869729002390 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 869729002391 potential frameshift: common BLAST hit: gi|110643711|ref|YP_671441.1| IS transposase 869729002392 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 869729002393 Helix-turn-helix domain; Region: HTH_28; pfam13518 869729002394 HTH-like domain; Region: HTH_21; pfam13276 869729002395 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 869729002396 Integrase core domain; Region: rve; pfam00665 869729002397 Integrase core domain; Region: rve_2; pfam13333 869729002398 Transposase; Region: DEDD_Tnp_IS110; pfam01548 869729002399 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 869729002400 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 869729002401 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 869729002402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729002403 putative substrate translocation pore; other site 869729002404 lipoprotein; Provisional; Region: PRK10759 869729002405 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 869729002406 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 869729002407 domain interface [polypeptide binding]; other site 869729002408 putative active site [active] 869729002409 catalytic site [active] 869729002410 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 869729002411 domain interface [polypeptide binding]; other site 869729002412 putative active site [active] 869729002413 catalytic site [active] 869729002414 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 869729002415 CoA binding domain; Region: CoA_binding_2; pfam13380 869729002416 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 869729002417 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 869729002418 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869729002419 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 869729002420 Uncharacterized conserved protein [Function unknown]; Region: COG3148 869729002421 thioredoxin 2; Provisional; Region: PRK10996 869729002422 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 869729002423 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 869729002424 catalytic residues [active] 869729002425 putative methyltransferase; Provisional; Region: PRK10864 869729002426 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 869729002427 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 869729002428 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 869729002429 ligand binding site [chemical binding]; other site 869729002430 active site 869729002431 UGI interface [polypeptide binding]; other site 869729002432 catalytic site [active] 869729002433 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 869729002434 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 869729002435 Transcriptional regulator [Transcription]; Region: LysR; COG0583 869729002436 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729002437 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 869729002438 dimerization interface [polypeptide binding]; other site 869729002439 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 869729002440 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 869729002441 ATP binding site [chemical binding]; other site 869729002442 Mg++ binding site [ion binding]; other site 869729002443 motif III; other site 869729002444 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869729002445 nucleotide binding region [chemical binding]; other site 869729002446 ATP-binding site [chemical binding]; other site 869729002447 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 869729002448 Methyltransferase domain; Region: Methyltransf_26; pfam13659 869729002449 L-aspartate oxidase; Provisional; Region: PRK09077 869729002450 L-aspartate oxidase; Provisional; Region: PRK06175 869729002451 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 869729002452 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 869729002453 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 869729002454 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 869729002455 DNA binding residues [nucleotide binding] 869729002456 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 869729002457 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 869729002458 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 869729002459 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 869729002460 anti-sigma E factor; Provisional; Region: rseB; PRK09455 869729002461 SoxR reducing system protein RseC; Provisional; Region: PRK10862 869729002462 GTP-binding protein LepA; Provisional; Region: PRK05433 869729002463 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 869729002464 G1 box; other site 869729002465 putative GEF interaction site [polypeptide binding]; other site 869729002466 GTP/Mg2+ binding site [chemical binding]; other site 869729002467 Switch I region; other site 869729002468 G2 box; other site 869729002469 G3 box; other site 869729002470 Switch II region; other site 869729002471 G4 box; other site 869729002472 G5 box; other site 869729002473 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 869729002474 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 869729002475 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 869729002476 signal peptidase I; Provisional; Region: PRK10861 869729002477 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 869729002478 Catalytic site [active] 869729002479 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 869729002480 ribonuclease III; Reviewed; Region: rnc; PRK00102 869729002481 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 869729002482 dimerization interface [polypeptide binding]; other site 869729002483 active site 869729002484 metal binding site [ion binding]; metal-binding site 869729002485 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 869729002486 dsRNA binding site [nucleotide binding]; other site 869729002487 GTPase Era; Reviewed; Region: era; PRK00089 869729002488 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 869729002489 G1 box; other site 869729002490 GTP/Mg2+ binding site [chemical binding]; other site 869729002491 Switch I region; other site 869729002492 G2 box; other site 869729002493 Switch II region; other site 869729002494 G3 box; other site 869729002495 G4 box; other site 869729002496 G5 box; other site 869729002497 KH domain; Region: KH_2; pfam07650 869729002498 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 869729002499 Recombination protein O N terminal; Region: RecO_N; pfam11967 869729002500 Recombination protein O C terminal; Region: RecO_C; pfam02565 869729002501 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 869729002502 active site 869729002503 hydrophilic channel; other site 869729002504 dimerization interface [polypeptide binding]; other site 869729002505 catalytic residues [active] 869729002506 active site lid [active] 869729002507 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 869729002508 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 869729002509 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 869729002510 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 869729002511 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 869729002512 putative active site [active] 869729002513 hypothetical protein; Provisional; Region: PRK11590 869729002514 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 869729002515 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 869729002516 nucleoside/Zn binding site; other site 869729002517 dimer interface [polypeptide binding]; other site 869729002518 catalytic motif [active] 869729002519 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 869729002520 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869729002521 substrate binding pocket [chemical binding]; other site 869729002522 membrane-bound complex binding site; other site 869729002523 hinge residues; other site 869729002524 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 869729002525 N-acetyl-D-glucosamine binding site [chemical binding]; other site 869729002526 catalytic residue [active] 869729002527 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 869729002528 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 869729002529 dimerization interface [polypeptide binding]; other site 869729002530 ATP binding site [chemical binding]; other site 869729002531 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 869729002532 dimerization interface [polypeptide binding]; other site 869729002533 ATP binding site [chemical binding]; other site 869729002534 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 869729002535 putative active site [active] 869729002536 catalytic triad [active] 869729002537 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869729002538 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869729002539 dimer interface [polypeptide binding]; other site 869729002540 phosphorylation site [posttranslational modification] 869729002541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729002542 ATP binding site [chemical binding]; other site 869729002543 Mg2+ binding site [ion binding]; other site 869729002544 G-X-G motif; other site 869729002545 hypothetical protein; Provisional; Region: PRK10722 869729002546 response regulator GlrR; Provisional; Region: PRK15115 869729002547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729002548 active site 869729002549 phosphorylation site [posttranslational modification] 869729002550 intermolecular recognition site; other site 869729002551 dimerization interface [polypeptide binding]; other site 869729002552 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729002553 Walker A motif; other site 869729002554 ATP binding site [chemical binding]; other site 869729002555 Walker B motif; other site 869729002556 arginine finger; other site 869729002557 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 869729002558 Nitrogen regulatory protein P-II; Region: P-II; smart00938 869729002559 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 869729002560 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 869729002561 heme-binding site [chemical binding]; other site 869729002562 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 869729002563 FAD binding pocket [chemical binding]; other site 869729002564 FAD binding motif [chemical binding]; other site 869729002565 phosphate binding motif [ion binding]; other site 869729002566 beta-alpha-beta structure motif; other site 869729002567 NAD binding pocket [chemical binding]; other site 869729002568 Heme binding pocket [chemical binding]; other site 869729002569 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 869729002570 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 869729002571 dimer interface [polypeptide binding]; other site 869729002572 active site 869729002573 glycine-pyridoxal phosphate binding site [chemical binding]; other site 869729002574 folate binding site [chemical binding]; other site 869729002575 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 869729002576 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 869729002577 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 869729002578 nucleotide binding site [chemical binding]; other site 869729002579 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869729002580 TPR motif; other site 869729002581 Tetratricopeptide repeat; Region: TPR_16; pfam13432 869729002582 binding surface 869729002583 TPR repeat; Region: TPR_11; pfam13414 869729002584 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869729002585 TPR motif; other site 869729002586 binding surface 869729002587 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 869729002588 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 869729002589 ligand binding site [chemical binding]; other site 869729002590 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 869729002591 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 869729002592 Walker A/P-loop; other site 869729002593 ATP binding site [chemical binding]; other site 869729002594 Q-loop/lid; other site 869729002595 ABC transporter signature motif; other site 869729002596 Walker B; other site 869729002597 D-loop; other site 869729002598 H-loop/switch region; other site 869729002599 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 869729002600 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869729002601 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 869729002602 TM-ABC transporter signature motif; other site 869729002603 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 869729002604 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 869729002605 putative NAD(P) binding site [chemical binding]; other site 869729002606 catalytic Zn binding site [ion binding]; other site 869729002607 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 869729002608 active site 869729002609 catalytic residues [active] 869729002610 Predicted membrane protein [Function unknown]; Region: COG2259 869729002611 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 869729002612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729002613 putative substrate translocation pore; other site 869729002614 potential frameshift: common BLAST hit: gi|117624763|ref|YP_853676.1| stationary phase inducible protein CsiE 869729002615 potential frameshift: common BLAST hit: gi|218690655|ref|YP_002398867.1| stationary phase inducible protein CsiE 869729002616 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 869729002617 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 869729002618 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 869729002619 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 869729002620 active site 869729002621 dimerization interface [polypeptide binding]; other site 869729002622 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 869729002623 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 869729002624 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 869729002625 Rrf2 family protein; Region: rrf2_super; TIGR00738 869729002626 cysteine desulfurase; Provisional; Region: PRK14012 869729002627 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 869729002628 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869729002629 catalytic residue [active] 869729002630 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 869729002631 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 869729002632 trimerization site [polypeptide binding]; other site 869729002633 active site 869729002634 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 869729002635 co-chaperone HscB; Provisional; Region: hscB; PRK05014 869729002636 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 869729002637 HSP70 interaction site [polypeptide binding]; other site 869729002638 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 869729002639 chaperone protein HscA; Provisional; Region: hscA; PRK05183 869729002640 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 869729002641 nucleotide binding site [chemical binding]; other site 869729002642 putative NEF/HSP70 interaction site [polypeptide binding]; other site 869729002643 SBD interface [polypeptide binding]; other site 869729002644 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 869729002645 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 869729002646 catalytic loop [active] 869729002647 iron binding site [ion binding]; other site 869729002648 hypothetical protein; Provisional; Region: PRK10721 869729002649 aminopeptidase B; Provisional; Region: PRK05015 869729002650 Peptidase; Region: DUF3663; pfam12404 869729002651 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 869729002652 interface (dimer of trimers) [polypeptide binding]; other site 869729002653 Substrate-binding/catalytic site; other site 869729002654 Zn-binding sites [ion binding]; other site 869729002655 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 869729002656 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 869729002657 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 869729002658 active site residue [active] 869729002659 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 869729002660 active site residue [active] 869729002661 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 869729002662 MG2 domain; Region: A2M_N; pfam01835 869729002663 Alpha-2-macroglobulin family; Region: A2M; pfam00207 869729002664 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 869729002665 surface patch; other site 869729002666 thioester region; other site 869729002667 specificity defining residues; other site 869729002668 potential frameshift: common BLAST hit: gi|218690639|ref|YP_002398851.1| penicillin-binding protein 1C 869729002669 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 869729002670 active site 869729002671 multimer interface [polypeptide binding]; other site 869729002672 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 869729002673 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869729002674 FeS/SAM binding site; other site 869729002675 cytoskeletal protein RodZ; Provisional; Region: PRK10856 869729002676 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869729002677 non-specific DNA binding site [nucleotide binding]; other site 869729002678 salt bridge; other site 869729002679 sequence-specific DNA binding site [nucleotide binding]; other site 869729002680 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 869729002681 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 869729002682 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 869729002683 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 869729002684 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 869729002685 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 869729002686 dimer interface [polypeptide binding]; other site 869729002687 motif 1; other site 869729002688 active site 869729002689 motif 2; other site 869729002690 motif 3; other site 869729002691 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 869729002692 anticodon binding site; other site 869729002693 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 869729002694 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 869729002695 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 869729002696 Trp docking motif [polypeptide binding]; other site 869729002697 active site 869729002698 GTP-binding protein Der; Reviewed; Region: PRK00093 869729002699 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 869729002700 G1 box; other site 869729002701 GTP/Mg2+ binding site [chemical binding]; other site 869729002702 Switch I region; other site 869729002703 G2 box; other site 869729002704 Switch II region; other site 869729002705 G3 box; other site 869729002706 G4 box; other site 869729002707 G5 box; other site 869729002708 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 869729002709 G1 box; other site 869729002710 GTP/Mg2+ binding site [chemical binding]; other site 869729002711 Switch I region; other site 869729002712 G2 box; other site 869729002713 G3 box; other site 869729002714 Switch II region; other site 869729002715 G4 box; other site 869729002716 G5 box; other site 869729002717 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 869729002718 intimin-like protein SinH; Provisional; Region: PRK15318 869729002719 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 869729002720 intimin-like protein SinH; Provisional; Region: PRK15318 869729002721 RatA-like protein; Provisional; Region: PRK15316 869729002722 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 869729002723 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 869729002724 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 869729002725 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 869729002726 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 869729002727 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 869729002728 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 869729002729 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 869729002730 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 869729002731 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 869729002732 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 869729002733 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 869729002734 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 869729002735 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 869729002736 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 869729002737 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 869729002738 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 869729002739 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 869729002740 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 869729002741 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 869729002742 generic binding surface II; other site 869729002743 generic binding surface I; other site 869729002744 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 869729002745 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 869729002746 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 869729002747 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 869729002748 active site 869729002749 GMP synthase; Reviewed; Region: guaA; PRK00074 869729002750 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 869729002751 AMP/PPi binding site [chemical binding]; other site 869729002752 candidate oxyanion hole; other site 869729002753 catalytic triad [active] 869729002754 potential glutamine specificity residues [chemical binding]; other site 869729002755 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 869729002756 ATP Binding subdomain [chemical binding]; other site 869729002757 Ligand Binding sites [chemical binding]; other site 869729002758 Dimerization subdomain; other site 869729002759 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 869729002760 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 869729002761 MASE1; Region: MASE1; pfam05231 869729002762 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 869729002763 diguanylate cyclase; Region: GGDEF; smart00267 869729002764 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 869729002765 exopolyphosphatase; Provisional; Region: PRK10854 869729002766 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 869729002767 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 869729002768 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 869729002769 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 869729002770 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 869729002771 domain interface [polypeptide binding]; other site 869729002772 active site 869729002773 catalytic site [active] 869729002774 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 869729002775 putative active site [active] 869729002776 catalytic site [active] 869729002777 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 869729002778 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 869729002779 active site 869729002780 substrate binding site [chemical binding]; other site 869729002781 cosubstrate binding site; other site 869729002782 catalytic site [active] 869729002783 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 869729002784 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 869729002785 dimerization interface [polypeptide binding]; other site 869729002786 putative ATP binding site [chemical binding]; other site 869729002787 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869729002788 active site 869729002789 uracil transporter; Provisional; Region: PRK10720 869729002790 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 869729002791 DNA replication initiation factor; Provisional; Region: PRK08084 869729002792 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 869729002793 ArsC family; Region: ArsC; pfam03960 869729002794 catalytic residues [active] 869729002795 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 869729002796 Peptidase family M48; Region: Peptidase_M48; cl12018 869729002797 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 869729002798 Domain of unknown function DUF20; Region: UPF0118; pfam01594 869729002799 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 869729002800 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 869729002801 catalytic triad [active] 869729002802 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 869729002803 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 869729002804 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 869729002805 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 869729002806 dihydrodipicolinate synthase; Region: dapA; TIGR00674 869729002807 dimer interface [polypeptide binding]; other site 869729002808 active site 869729002809 catalytic residue [active] 869729002810 lipoprotein; Provisional; Region: PRK11679 869729002811 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 869729002812 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 869729002813 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 869729002814 ATP binding site [chemical binding]; other site 869729002815 active site 869729002816 substrate binding site [chemical binding]; other site 869729002817 Predicted metalloprotease [General function prediction only]; Region: COG2321 869729002818 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 869729002819 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 869729002820 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 869729002821 Helicase; Region: Helicase_RecD; pfam05127 869729002822 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 869729002823 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 869729002824 putative hydrolase; Provisional; Region: PRK11460 869729002825 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 869729002826 hypothetical protein; Provisional; Region: PRK13664 869729002827 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 869729002828 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 869729002829 metal binding site [ion binding]; metal-binding site 869729002830 dimer interface [polypeptide binding]; other site 869729002831 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 869729002832 ArsC family; Region: ArsC; pfam03960 869729002833 putative catalytic residues [active] 869729002834 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 869729002835 Protein export membrane protein; Region: SecD_SecF; cl14618 869729002836 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869729002837 dimerization interface [polypeptide binding]; other site 869729002838 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 869729002839 Histidine kinase; Region: HisKA_3; pfam07730 869729002840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729002841 ATP binding site [chemical binding]; other site 869729002842 Mg2+ binding site [ion binding]; other site 869729002843 G-X-G motif; other site 869729002844 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 869729002845 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 869729002846 4Fe-4S binding domain; Region: Fer4; pfam00037 869729002847 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 869729002848 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869729002849 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 869729002850 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 869729002851 dimer interface [polypeptide binding]; other site 869729002852 ADP-ribose binding site [chemical binding]; other site 869729002853 active site 869729002854 nudix motif; other site 869729002855 metal binding site [ion binding]; metal-binding site 869729002856 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 869729002857 transketolase; Reviewed; Region: PRK12753 869729002858 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 869729002859 TPP-binding site [chemical binding]; other site 869729002860 dimer interface [polypeptide binding]; other site 869729002861 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 869729002862 PYR/PP interface [polypeptide binding]; other site 869729002863 dimer interface [polypeptide binding]; other site 869729002864 TPP binding site [chemical binding]; other site 869729002865 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869729002866 transaldolase-like protein; Provisional; Region: PTZ00411 869729002867 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 869729002868 active site 869729002869 dimer interface [polypeptide binding]; other site 869729002870 catalytic residue [active] 869729002871 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 869729002872 Malic enzyme, N-terminal domain; Region: malic; pfam00390 869729002873 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 869729002874 putative NAD(P) binding site [chemical binding]; other site 869729002875 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 869729002876 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 869729002877 putative hexamer interface [polypeptide binding]; other site 869729002878 putative hexagonal pore; other site 869729002879 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 869729002880 G1 box; other site 869729002881 GTP/Mg2+ binding site [chemical binding]; other site 869729002882 G2 box; other site 869729002883 Switch I region; other site 869729002884 G3 box; other site 869729002885 Switch II region; other site 869729002886 G4 box; other site 869729002887 G5 box; other site 869729002888 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 869729002889 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 869729002890 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 869729002891 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 869729002892 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 869729002893 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 869729002894 Hexamer interface [polypeptide binding]; other site 869729002895 Putative hexagonal pore residue; other site 869729002896 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 869729002897 Hexamer/Pentamer interface [polypeptide binding]; other site 869729002898 central pore; other site 869729002899 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 869729002900 putative catalytic cysteine [active] 869729002901 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 869729002902 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 869729002903 nucleotide binding site [chemical binding]; other site 869729002904 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 869729002905 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 869729002906 active site 869729002907 metal binding site [ion binding]; metal-binding site 869729002908 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 869729002909 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 869729002910 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 869729002911 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 869729002912 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 869729002913 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 869729002914 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 869729002915 putative hexamer interface [polypeptide binding]; other site 869729002916 putative hexagonal pore; other site 869729002917 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 869729002918 putative hexamer interface [polypeptide binding]; other site 869729002919 putative hexagonal pore; other site 869729002920 carboxysome structural protein EutK; Provisional; Region: PRK15466 869729002921 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 869729002922 Hexamer interface [polypeptide binding]; other site 869729002923 Hexagonal pore residue; other site 869729002924 transcriptional regulator EutR; Provisional; Region: PRK10130 869729002925 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729002926 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729002927 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 869729002928 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 869729002929 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 869729002930 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 869729002931 active site 869729002932 metal binding site [ion binding]; metal-binding site 869729002933 putative acetyltransferase; Provisional; Region: PRK03624 869729002934 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869729002935 Coenzyme A binding pocket [chemical binding]; other site 869729002936 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 869729002937 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 869729002938 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 869729002939 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 869729002940 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 869729002941 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869729002942 active site turn [active] 869729002943 phosphorylation site [posttranslational modification] 869729002944 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869729002945 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 869729002946 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 869729002947 putative active site [active] 869729002948 short chain dehydrogenase; Provisional; Region: PRK08226 869729002949 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 869729002950 NAD binding site [chemical binding]; other site 869729002951 homotetramer interface [polypeptide binding]; other site 869729002952 homodimer interface [polypeptide binding]; other site 869729002953 active site 869729002954 thiosulfate transporter subunit; Provisional; Region: PRK10852 869729002955 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 869729002956 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 869729002957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729002958 dimer interface [polypeptide binding]; other site 869729002959 conserved gate region; other site 869729002960 putative PBP binding loops; other site 869729002961 ABC-ATPase subunit interface; other site 869729002962 sulfate transport protein; Provisional; Region: cysT; CHL00187 869729002963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729002964 dimer interface [polypeptide binding]; other site 869729002965 conserved gate region; other site 869729002966 putative PBP binding loops; other site 869729002967 ABC-ATPase subunit interface; other site 869729002968 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 869729002969 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 869729002970 Walker A/P-loop; other site 869729002971 ATP binding site [chemical binding]; other site 869729002972 Q-loop/lid; other site 869729002973 ABC transporter signature motif; other site 869729002974 Walker B; other site 869729002975 D-loop; other site 869729002976 H-loop/switch region; other site 869729002977 TOBE-like domain; Region: TOBE_3; pfam12857 869729002978 cysteine synthase B; Region: cysM; TIGR01138 869729002979 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 869729002980 dimer interface [polypeptide binding]; other site 869729002981 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729002982 catalytic residue [active] 869729002983 hypothetical protein; Provisional; Region: PRK10318 869729002984 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 869729002985 dimer interface [polypeptide binding]; other site 869729002986 pyridoxamine kinase; Validated; Region: PRK05756 869729002987 pyridoxal binding site [chemical binding]; other site 869729002988 ATP binding site [chemical binding]; other site 869729002989 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 869729002990 HPr interaction site; other site 869729002991 glycerol kinase (GK) interaction site [polypeptide binding]; other site 869729002992 active site 869729002993 phosphorylation site [posttranslational modification] 869729002994 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 869729002995 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 869729002996 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 869729002997 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 869729002998 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 869729002999 dimerization domain swap beta strand [polypeptide binding]; other site 869729003000 regulatory protein interface [polypeptide binding]; other site 869729003001 active site 869729003002 regulatory phosphorylation site [posttranslational modification]; other site 869729003003 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 869729003004 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 869729003005 dimer interface [polypeptide binding]; other site 869729003006 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729003007 catalytic residue [active] 869729003008 putative sulfate transport protein CysZ; Validated; Region: PRK04949 869729003009 cell division protein ZipA; Provisional; Region: PRK03427 869729003010 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 869729003011 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 869729003012 FtsZ protein binding site [polypeptide binding]; other site 869729003013 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 869729003014 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 869729003015 nucleotide binding pocket [chemical binding]; other site 869729003016 K-X-D-G motif; other site 869729003017 catalytic site [active] 869729003018 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 869729003019 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 869729003020 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 869729003021 Dimer interface [polypeptide binding]; other site 869729003022 BRCT sequence motif; other site 869729003023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 869729003024 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 869729003025 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 869729003026 Transcriptional regulator [Transcription]; Region: LysR; COG0583 869729003027 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729003028 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 869729003029 putative dimerization interface [polypeptide binding]; other site 869729003030 hypothetical protein; Provisional; Region: PRK11528 869729003031 purine nucleoside phosphorylase; Provisional; Region: PRK08202 869729003032 nucleoside transporter; Region: 2A0110; TIGR00889 869729003033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729003034 putative substrate translocation pore; other site 869729003035 XapX domain; Region: XapX; TIGR03510 869729003036 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 869729003037 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729003038 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 869729003039 putative dimerization interface [polypeptide binding]; other site 869729003040 putative substrate binding pocket [chemical binding]; other site 869729003041 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 869729003042 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 869729003043 active site 869729003044 HIGH motif; other site 869729003045 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 869729003046 active site 869729003047 KMSKS motif; other site 869729003048 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869729003049 salt bridge; other site 869729003050 non-specific DNA binding site [nucleotide binding]; other site 869729003051 sequence-specific DNA binding site [nucleotide binding]; other site 869729003052 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 869729003053 MASE1; Region: MASE1; pfam05231 869729003054 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 869729003055 diguanylate cyclase; Region: GGDEF; smart00267 869729003056 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 869729003057 potential frameshift: common BLAST hit: gi|378712131|ref|YP_005277024.1| nucleoside transporter 869729003058 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 869729003059 Nucleoside recognition; Region: Gate; pfam07670 869729003060 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 869729003061 manganese transport protein MntH; Reviewed; Region: PRK00701 869729003062 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 869729003063 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 869729003064 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 869729003065 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 869729003066 Cl- selectivity filter; other site 869729003067 Cl- binding residues [ion binding]; other site 869729003068 pore gating glutamate residue; other site 869729003069 dimer interface [polypeptide binding]; other site 869729003070 glucokinase, proteobacterial type; Region: glk; TIGR00749 869729003071 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 869729003072 nucleotide binding site [chemical binding]; other site 869729003073 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 869729003074 active site 869729003075 P-loop; other site 869729003076 phosphorylation site [posttranslational modification] 869729003077 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 869729003078 aminopeptidase; Provisional; Region: PRK09795 869729003079 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 869729003080 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 869729003081 active site 869729003082 exoaminopeptidase; Provisional; Region: PRK09961 869729003083 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 869729003084 oligomer interface [polypeptide binding]; other site 869729003085 active site 869729003086 metal binding site [ion binding]; metal-binding site 869729003087 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 869729003088 dimerization domain swap beta strand [polypeptide binding]; other site 869729003089 regulatory protein interface [polypeptide binding]; other site 869729003090 active site 869729003091 regulatory phosphorylation site [posttranslational modification]; other site 869729003092 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 869729003093 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 869729003094 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 869729003095 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 869729003096 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869729003097 active site 869729003098 phosphorylation site [posttranslational modification] 869729003099 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 869729003100 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729003101 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 869729003102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729003103 active site 869729003104 phosphorylation site [posttranslational modification] 869729003105 intermolecular recognition site; other site 869729003106 dimerization interface [polypeptide binding]; other site 869729003107 LytTr DNA-binding domain; Region: LytTR; pfam04397 869729003108 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 869729003109 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 869729003110 Histidine kinase; Region: His_kinase; pfam06580 869729003111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729003112 ATP binding site [chemical binding]; other site 869729003113 Mg2+ binding site [ion binding]; other site 869729003114 G-X-G motif; other site 869729003115 aminotransferase; Validated; Region: PRK08175 869729003116 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869729003117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729003118 homodimer interface [polypeptide binding]; other site 869729003119 catalytic residue [active] 869729003120 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 869729003121 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 869729003122 putative acyl-acceptor binding pocket; other site 869729003123 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 869729003124 hypothetical protein; Provisional; Region: PRK10316 869729003125 YfdX protein; Region: YfdX; pfam10938 869729003126 formyl-coenzyme A transferase; Provisional; Region: PRK05398 869729003127 CoA-transferase family III; Region: CoA_transf_3; pfam02515 869729003128 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 869729003129 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 869729003130 PYR/PP interface [polypeptide binding]; other site 869729003131 dimer interface [polypeptide binding]; other site 869729003132 TPP binding site [chemical binding]; other site 869729003133 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 869729003134 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 869729003135 TPP-binding site; other site 869729003136 dimer interface [polypeptide binding]; other site 869729003137 putative transporter YfdV; Provisional; Region: PRK09903 869729003138 putative CoA-transferase; Provisional; Region: PRK11430 869729003139 CoA-transferase family III; Region: CoA_transf_3; pfam02515 869729003140 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 869729003141 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869729003142 substrate binding pocket [chemical binding]; other site 869729003143 membrane-bound complex binding site; other site 869729003144 hinge residues; other site 869729003145 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869729003146 substrate binding pocket [chemical binding]; other site 869729003147 membrane-bound complex binding site; other site 869729003148 hinge residues; other site 869729003149 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869729003150 dimer interface [polypeptide binding]; other site 869729003151 phosphorylation site [posttranslational modification] 869729003152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729003153 ATP binding site [chemical binding]; other site 869729003154 Mg2+ binding site [ion binding]; other site 869729003155 G-X-G motif; other site 869729003156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729003157 active site 869729003158 phosphorylation site [posttranslational modification] 869729003159 intermolecular recognition site; other site 869729003160 dimerization interface [polypeptide binding]; other site 869729003161 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 869729003162 putative binding surface; other site 869729003163 active site 869729003164 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 869729003165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729003166 active site 869729003167 phosphorylation site [posttranslational modification] 869729003168 intermolecular recognition site; other site 869729003169 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869729003170 DNA binding residues [nucleotide binding] 869729003171 dimerization interface [polypeptide binding]; other site 869729003172 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 869729003173 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 869729003174 HlyD family secretion protein; Region: HlyD_3; pfam13437 869729003175 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 869729003176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729003177 putative substrate translocation pore; other site 869729003178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729003179 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 869729003180 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 869729003181 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869729003182 catalytic residue [active] 869729003183 permease DsdX; Provisional; Region: PRK09921 869729003184 gluconate transporter; Region: gntP; TIGR00791 869729003185 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 869729003186 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729003187 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 869729003188 dimerization interface [polypeptide binding]; other site 869729003189 substrate binding pocket [chemical binding]; other site 869729003190 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 869729003191 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 869729003192 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 869729003193 Protein of unknown function (DUF551); Region: DUF551; pfam04448 869729003194 Protein of unknown function (DUF2856); Region: DUF2856; pfam11043 869729003195 ERF superfamily; Region: ERF; pfam04404 869729003196 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 869729003197 Lambda Phage CIII; Region: Lambda_CIII; pfam02061 869729003198 Antirestriction protein Ral; Region: Ral; pfam11058 869729003199 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 869729003200 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869729003201 non-specific DNA binding site [nucleotide binding]; other site 869729003202 salt bridge; other site 869729003203 sequence-specific DNA binding site [nucleotide binding]; other site 869729003204 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 869729003205 Catalytic site [active] 869729003206 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 869729003207 Bacteriophage CII protein; Region: Phage_CII; pfam05269 869729003208 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 869729003209 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 869729003210 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 869729003211 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 869729003212 Walker A motif; other site 869729003213 ATP binding site [chemical binding]; other site 869729003214 Walker B motif; other site 869729003215 DNA binding loops [nucleotide binding] 869729003216 NinB protein; Region: NinB; pfam05772 869729003217 NINE Protein; Region: NinE; pfam05322 869729003218 Protein of unknown function (DUF2591); Region: DUF2591; pfam10765 869729003219 NinF protein; Region: NinF; pfam05810 869729003220 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 869729003221 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 869729003222 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 869729003223 Endodeoxyribonuclease RusA; Region: RusA; cl01885 869729003224 Phage NinH protein; Region: Phage_NinH; pfam06322 869729003225 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 869729003226 phage holin, lambda family; Region: holin_lambda; TIGR01594 869729003227 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 869729003228 N-acetyl-D-glucosamine binding site [chemical binding]; other site 869729003229 catalytic residue [active] 869729003230 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 869729003231 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 869729003232 ORF11CD3 domain; Region: ORF11CD3; pfam10549 869729003233 Protein of unknown function (DUF2560); Region: DUF2560; pfam10834 869729003234 Phage terminase large subunit; Region: Terminase_3; pfam04466 869729003235 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 869729003236 P22 tail accessory factor; Region: P22_Tail-4; pfam11650 869729003237 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 869729003238 Protein of unknown function (DUF2824); Region: DUF2824; pfam11039 869729003239 Toxin YafO, type II toxin-antitoxin system; Region: YafO_toxin; pfam13957 869729003240 Mnt; Region: mnt; PHA01513 869729003241 Arc-like DNA binding domain; Region: Arc; pfam03869 869729003242 Regulatory protein Mnt; Region: Repressor_Mnt; pfam11423 869729003243 Arc-like DNA binding domain; Region: Arc; pfam03869 869729003244 Mnt; Region: mnt; PHA01513 869729003245 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 869729003246 Prophage antirepressor [Transcription]; Region: COG3617 869729003247 Phage anti-repressor protein [Transcription]; Region: COG3561 869729003248 Head binding; Region: Head_binding; pfam09008 869729003249 N terminal extension of bacteriophage endosialidase; Region: End_N_terminal; pfam12218 869729003250 Beta barrel domain of bacteriophage endosialidase; Region: End_beta_barrel; pfam12195 869729003251 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 869729003252 Asp-box motif; other site 869729003253 catalytic site [active] 869729003254 Catalytic domain of bacteriophage endosialidase; Region: End_tail_spike; pfam12219 869729003255 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 869729003256 integrase; Provisional; Region: PRK09692 869729003257 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 869729003258 active site 869729003259 Int/Topo IB signature motif; other site 869729003260 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 869729003261 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 869729003262 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 869729003263 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 869729003264 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 869729003265 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 869729003266 dimer interface [polypeptide binding]; other site 869729003267 active site 869729003268 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 869729003269 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 869729003270 substrate binding site [chemical binding]; other site 869729003271 oxyanion hole (OAH) forming residues; other site 869729003272 trimer interface [polypeptide binding]; other site 869729003273 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 869729003274 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 869729003275 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869729003276 catalytic core [active] 869729003277 Fimbrial protein; Region: Fimbrial; cl01416 869729003278 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 869729003279 PapC N-terminal domain; Region: PapC_N; pfam13954 869729003280 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 869729003281 PapC C-terminal domain; Region: PapC_C; pfam13953 869729003282 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 869729003283 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 869729003284 Fimbrial protein; Region: Fimbrial; cl01416 869729003285 Fimbrial protein; Region: Fimbrial; cl01416 869729003286 Fimbrial protein; Region: Fimbrial; cl01416 869729003287 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 869729003288 hypothetical protein; Provisional; Region: PRK04946 869729003289 Smr domain; Region: Smr; pfam01713 869729003290 HemK family putative methylases; Region: hemK_fam; TIGR00536 869729003291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729003292 S-adenosylmethionine binding site [chemical binding]; other site 869729003293 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 869729003294 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 869729003295 Tetramer interface [polypeptide binding]; other site 869729003296 active site 869729003297 FMN-binding site [chemical binding]; other site 869729003298 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 869729003299 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 869729003300 hypothetical protein; Provisional; Region: PRK10621 869729003301 Predicted permeases [General function prediction only]; Region: COG0730 869729003302 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 869729003303 YfcL protein; Region: YfcL; pfam08891 869729003304 Uncharacterized conserved protein [Function unknown]; Region: COG4121 869729003305 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 869729003306 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 869729003307 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 869729003308 dimer interface [polypeptide binding]; other site 869729003309 active site 869729003310 putative transporter; Provisional; Region: PRK12382 869729003311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729003312 putative substrate translocation pore; other site 869729003313 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 869729003314 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 869729003315 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 869729003316 ligand binding site [chemical binding]; other site 869729003317 NAD binding site [chemical binding]; other site 869729003318 catalytic site [active] 869729003319 homodimer interface [polypeptide binding]; other site 869729003320 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 869729003321 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 869729003322 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 869729003323 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 869729003324 dimerization interface 3.5A [polypeptide binding]; other site 869729003325 active site 869729003326 hypothetical protein; Provisional; Region: PRK10847 869729003327 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 869729003328 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 869729003329 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 869729003330 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 869729003331 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869729003332 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869729003333 cell division protein DedD; Provisional; Region: PRK11633 869729003334 Sporulation related domain; Region: SPOR; pfam05036 869729003335 colicin V production protein; Provisional; Region: PRK10845 869729003336 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 869729003337 amidophosphoribosyltransferase; Provisional; Region: PRK09246 869729003338 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 869729003339 active site 869729003340 tetramer interface [polypeptide binding]; other site 869729003341 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869729003342 active site 869729003343 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 869729003344 Flavoprotein; Region: Flavoprotein; pfam02441 869729003345 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 869729003346 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869729003347 substrate binding pocket [chemical binding]; other site 869729003348 membrane-bound complex binding site; other site 869729003349 hinge residues; other site 869729003350 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 869729003351 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869729003352 substrate binding pocket [chemical binding]; other site 869729003353 membrane-bound complex binding site; other site 869729003354 hinge residues; other site 869729003355 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 869729003356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729003357 dimer interface [polypeptide binding]; other site 869729003358 conserved gate region; other site 869729003359 putative PBP binding loops; other site 869729003360 ABC-ATPase subunit interface; other site 869729003361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729003362 dimer interface [polypeptide binding]; other site 869729003363 conserved gate region; other site 869729003364 putative PBP binding loops; other site 869729003365 ABC-ATPase subunit interface; other site 869729003366 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 869729003367 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 869729003368 Walker A/P-loop; other site 869729003369 ATP binding site [chemical binding]; other site 869729003370 Q-loop/lid; other site 869729003371 ABC transporter signature motif; other site 869729003372 Walker B; other site 869729003373 D-loop; other site 869729003374 H-loop/switch region; other site 869729003375 putative transposase; Provisional; Region: PRK09857 869729003376 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 869729003377 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 869729003378 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 869729003379 putative NAD(P) binding site [chemical binding]; other site 869729003380 putative active site [active] 869729003381 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 869729003382 homooctamer interface [polypeptide binding]; other site 869729003383 active site 869729003384 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 869729003385 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 869729003386 C-terminal domain interface [polypeptide binding]; other site 869729003387 GSH binding site (G-site) [chemical binding]; other site 869729003388 dimer interface [polypeptide binding]; other site 869729003389 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 869729003390 N-terminal domain interface [polypeptide binding]; other site 869729003391 putative dimer interface [polypeptide binding]; other site 869729003392 active site 869729003393 glutathione S-transferase; Provisional; Region: PRK15113 869729003394 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 869729003395 C-terminal domain interface [polypeptide binding]; other site 869729003396 GSH binding site (G-site) [chemical binding]; other site 869729003397 dimer interface [polypeptide binding]; other site 869729003398 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 869729003399 N-terminal domain interface [polypeptide binding]; other site 869729003400 putative dimer interface [polypeptide binding]; other site 869729003401 putative substrate binding pocket (H-site) [chemical binding]; other site 869729003402 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 869729003403 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 869729003404 active site 869729003405 metal binding site [ion binding]; metal-binding site 869729003406 homotetramer interface [polypeptide binding]; other site 869729003407 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 869729003408 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 869729003409 nudix motif; other site 869729003410 hypothetical protein; Provisional; Region: PRK11588 869729003411 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 869729003412 phosphate acetyltransferase; Reviewed; Region: PRK05632 869729003413 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 869729003414 DRTGG domain; Region: DRTGG; pfam07085 869729003415 phosphate acetyltransferase; Region: pta; TIGR00651 869729003416 propionate/acetate kinase; Provisional; Region: PRK12379 869729003417 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 869729003418 hypothetical protein; Provisional; Region: PRK01816 869729003419 hypothetical protein; Validated; Region: PRK05445 869729003420 putative phosphatase; Provisional; Region: PRK11587 869729003421 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869729003422 motif II; other site 869729003423 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 869729003424 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 869729003425 TrkA-C domain; Region: TrkA_C; pfam02080 869729003426 TrkA-C domain; Region: TrkA_C; pfam02080 869729003427 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 869729003428 5'-nucleotidase; Provisional; Region: PRK03826 869729003429 aminotransferase AlaT; Validated; Region: PRK09265 869729003430 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869729003431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729003432 homodimer interface [polypeptide binding]; other site 869729003433 catalytic residue [active] 869729003434 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 869729003435 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729003436 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 869729003437 putative dimerization interface [polypeptide binding]; other site 869729003438 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 869729003439 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 869729003440 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 869729003441 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 869729003442 NADH dehydrogenase subunit D; Validated; Region: PRK06075 869729003443 NADH dehydrogenase subunit E; Validated; Region: PRK07539 869729003444 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 869729003445 putative dimer interface [polypeptide binding]; other site 869729003446 [2Fe-2S] cluster binding site [ion binding]; other site 869729003447 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 869729003448 SLBB domain; Region: SLBB; pfam10531 869729003449 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 869729003450 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 869729003451 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 869729003452 catalytic loop [active] 869729003453 iron binding site [ion binding]; other site 869729003454 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 869729003455 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 869729003456 [4Fe-4S] binding site [ion binding]; other site 869729003457 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 869729003458 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 869729003459 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 869729003460 4Fe-4S binding domain; Region: Fer4; pfam00037 869729003461 4Fe-4S binding domain; Region: Fer4; pfam00037 869729003462 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 869729003463 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 869729003464 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 869729003465 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 869729003466 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 869729003467 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 869729003468 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 869729003469 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 869729003470 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 869729003471 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 869729003472 M28 Zn-Peptidases; Region: M28_like_1; cd05640 869729003473 Peptidase family M28; Region: Peptidase_M28; pfam04389 869729003474 metal binding site [ion binding]; metal-binding site 869729003475 von Willebrand factor; Region: vWF_A; pfam12450 869729003476 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 869729003477 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 869729003478 metal ion-dependent adhesion site (MIDAS); other site 869729003479 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 869729003480 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 869729003481 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869729003482 Coenzyme A binding pocket [chemical binding]; other site 869729003483 hypothetical protein; Provisional; Region: PRK10404 869729003484 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 869729003485 isochorismate synthases; Region: isochor_syn; TIGR00543 869729003486 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 869729003487 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 869729003488 dimer interface [polypeptide binding]; other site 869729003489 tetramer interface [polypeptide binding]; other site 869729003490 PYR/PP interface [polypeptide binding]; other site 869729003491 TPP binding site [chemical binding]; other site 869729003492 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 869729003493 TPP-binding site; other site 869729003494 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 869729003495 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 869729003496 catalytic site [active] 869729003497 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 869729003498 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 869729003499 substrate binding site [chemical binding]; other site 869729003500 oxyanion hole (OAH) forming residues; other site 869729003501 trimer interface [polypeptide binding]; other site 869729003502 O-succinylbenzoate synthase; Provisional; Region: PRK05105 869729003503 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 869729003504 active site 869729003505 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 869729003506 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 869729003507 acyl-activating enzyme (AAE) consensus motif; other site 869729003508 putative AMP binding site [chemical binding]; other site 869729003509 putative active site [active] 869729003510 putative CoA binding site [chemical binding]; other site 869729003511 signal transduction protein PmrD; Provisional; Region: PRK15450 869729003512 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 869729003513 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 869729003514 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 869729003515 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 869729003516 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 869729003517 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 869729003518 putative active site [active] 869729003519 putative catalytic site [active] 869729003520 putative Zn binding site [ion binding]; other site 869729003521 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 869729003522 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 869729003523 substrate binding site [chemical binding]; other site 869729003524 cosubstrate binding site; other site 869729003525 catalytic site [active] 869729003526 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 869729003527 active site 869729003528 hexamer interface [polypeptide binding]; other site 869729003529 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 869729003530 NAD binding site [chemical binding]; other site 869729003531 substrate binding site [chemical binding]; other site 869729003532 active site 869729003533 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 869729003534 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 869729003535 Ligand binding site; other site 869729003536 Putative Catalytic site; other site 869729003537 DXD motif; other site 869729003538 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 869729003539 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 869729003540 inhibitor-cofactor binding pocket; inhibition site 869729003541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729003542 catalytic residue [active] 869729003543 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 869729003544 catalytic core [active] 869729003545 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 869729003546 YfaZ precursor; Region: YfaZ; pfam07437 869729003547 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 869729003548 hypothetical protein; Provisional; Region: PRK03673 869729003549 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 869729003550 putative MPT binding site; other site 869729003551 Competence-damaged protein; Region: CinA; cl00666 869729003552 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 869729003553 Transcriptional regulator [Transcription]; Region: IclR; COG1414 869729003554 Bacterial transcriptional regulator; Region: IclR; pfam01614 869729003555 L-rhamnonate dehydratase; Provisional; Region: PRK15440 869729003556 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 869729003557 putative active site pocket [active] 869729003558 putative metal binding site [ion binding]; other site 869729003559 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 869729003560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729003561 putative substrate translocation pore; other site 869729003562 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 869729003563 hypothetical protein; Provisional; Region: PRK09956 869729003564 hypothetical protein; Provisional; Region: PRK09956 869729003565 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 869729003566 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 869729003567 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 869729003568 Cysteine-rich domain; Region: CCG; pfam02754 869729003569 Cysteine-rich domain; Region: CCG; pfam02754 869729003570 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 869729003571 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 869729003572 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 869729003573 hydroxyglutarate oxidase; Provisional; Region: PRK11728 869729003574 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 869729003575 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 869729003576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729003577 putative substrate translocation pore; other site 869729003578 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 869729003579 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 869729003580 active site 869729003581 catalytic site [active] 869729003582 metal binding site [ion binding]; metal-binding site 869729003583 hypothetical protein; Provisional; Region: PRK09902 869729003584 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 869729003585 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 869729003586 catalytic loop [active] 869729003587 iron binding site [ion binding]; other site 869729003588 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 869729003589 dimer interface [polypeptide binding]; other site 869729003590 putative radical transfer pathway; other site 869729003591 diiron center [ion binding]; other site 869729003592 tyrosyl radical; other site 869729003593 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 869729003594 ATP cone domain; Region: ATP-cone; pfam03477 869729003595 Class I ribonucleotide reductase; Region: RNR_I; cd01679 869729003596 active site 869729003597 dimer interface [polypeptide binding]; other site 869729003598 catalytic residues [active] 869729003599 effector binding site; other site 869729003600 R2 peptide binding site; other site 869729003601 adhesin; Provisional; Region: PRK09752 869729003602 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 869729003603 Autotransporter beta-domain; Region: Autotransporter; pfam03797 869729003604 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 869729003605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729003606 S-adenosylmethionine binding site [chemical binding]; other site 869729003607 DNA gyrase subunit A; Validated; Region: PRK05560 869729003608 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 869729003609 CAP-like domain; other site 869729003610 active site 869729003611 primary dimer interface [polypeptide binding]; other site 869729003612 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869729003613 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869729003614 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869729003615 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869729003616 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869729003617 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869729003618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 869729003619 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 869729003620 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 869729003621 MG2 domain; Region: A2M_N; pfam01835 869729003622 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 869729003623 Alpha-2-macroglobulin family; Region: A2M; pfam00207 869729003624 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 869729003625 Predicted secreted protein [Function unknown]; Region: COG5445 869729003626 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 869729003627 Predicted secreted protein [Function unknown]; Region: COG5445 869729003628 Stage II sporulation protein; Region: SpoIID; pfam08486 869729003629 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 869729003630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 869729003631 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 869729003632 putative acyltransferase; Provisional; Region: PRK05790 869729003633 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 869729003634 dimer interface [polypeptide binding]; other site 869729003635 active site 869729003636 Short chain fatty acid transporter; Region: SCFA_trans; pfam02667 869729003637 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 869729003638 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920 869729003639 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 869729003640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729003641 active site 869729003642 phosphorylation site [posttranslational modification] 869729003643 intermolecular recognition site; other site 869729003644 dimerization interface [polypeptide binding]; other site 869729003645 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729003646 Walker A motif; other site 869729003647 ATP binding site [chemical binding]; other site 869729003648 Walker B motif; other site 869729003649 arginine finger; other site 869729003650 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 869729003651 sensory histidine kinase AtoS; Provisional; Region: PRK11360 869729003652 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869729003653 putative active site [active] 869729003654 heme pocket [chemical binding]; other site 869729003655 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869729003656 dimer interface [polypeptide binding]; other site 869729003657 phosphorylation site [posttranslational modification] 869729003658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729003659 ATP binding site [chemical binding]; other site 869729003660 Mg2+ binding site [ion binding]; other site 869729003661 G-X-G motif; other site 869729003662 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 869729003663 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869729003664 dimer interface [polypeptide binding]; other site 869729003665 phosphorylation site [posttranslational modification] 869729003666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729003667 ATP binding site [chemical binding]; other site 869729003668 Mg2+ binding site [ion binding]; other site 869729003669 G-X-G motif; other site 869729003670 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 869729003671 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729003672 active site 869729003673 phosphorylation site [posttranslational modification] 869729003674 intermolecular recognition site; other site 869729003675 dimerization interface [polypeptide binding]; other site 869729003676 transcriptional regulator RcsB; Provisional; Region: PRK10840 869729003677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729003678 active site 869729003679 phosphorylation site [posttranslational modification] 869729003680 intermolecular recognition site; other site 869729003681 dimerization interface [polypeptide binding]; other site 869729003682 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869729003683 DNA binding residues [nucleotide binding] 869729003684 dimerization interface [polypeptide binding]; other site 869729003685 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 869729003686 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729003687 ATP binding site [chemical binding]; other site 869729003688 G-X-G motif; other site 869729003689 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 869729003690 putative binding surface; other site 869729003691 active site 869729003692 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 869729003693 outer membrane porin protein C; Provisional; Region: PRK10554 869729003694 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 869729003695 ApbE family; Region: ApbE; pfam02424 869729003696 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 869729003697 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 869729003698 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729003699 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 869729003700 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 869729003701 DNA binding site [nucleotide binding] 869729003702 active site 869729003703 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 869729003704 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 869729003705 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 869729003706 Walker A/P-loop; other site 869729003707 ATP binding site [chemical binding]; other site 869729003708 Q-loop/lid; other site 869729003709 ABC transporter signature motif; other site 869729003710 Walker B; other site 869729003711 D-loop; other site 869729003712 H-loop/switch region; other site 869729003713 malate:quinone oxidoreductase; Validated; Region: PRK05257 869729003714 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 869729003715 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 869729003716 secondary substrate binding site; other site 869729003717 primary substrate binding site; other site 869729003718 inhibition loop; other site 869729003719 dimerization interface [polypeptide binding]; other site 869729003720 tRNA synthetases class I (R); Region: tRNA-synt_1d; pfam00750 869729003721 ferredoxin-type protein; Provisional; Region: PRK10194 869729003722 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 869729003723 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 869729003724 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 869729003725 [4Fe-4S] binding site [ion binding]; other site 869729003726 molybdopterin cofactor binding site; other site 869729003727 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 869729003728 molybdopterin cofactor binding site; other site 869729003729 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 869729003730 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 869729003731 4Fe-4S binding domain; Region: Fer4_5; pfam12801 869729003732 4Fe-4S binding domain; Region: Fer4_6; pfam12837 869729003733 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 869729003734 cytochrome c-type protein NapC; Provisional; Region: PRK10617 869729003735 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 869729003736 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 869729003737 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 869729003738 Walker A/P-loop; other site 869729003739 ATP binding site [chemical binding]; other site 869729003740 Q-loop/lid; other site 869729003741 ABC transporter signature motif; other site 869729003742 Walker B; other site 869729003743 D-loop; other site 869729003744 H-loop/switch region; other site 869729003745 heme exporter protein CcmB; Region: ccmB; TIGR01190 869729003746 heme exporter protein CcmC; Region: ccmC; TIGR01191 869729003747 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 869729003748 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 869729003749 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 869729003750 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 869729003751 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 869729003752 catalytic residues [active] 869729003753 central insert; other site 869729003754 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 869729003755 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 869729003756 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 869729003757 binding surface 869729003758 TPR motif; other site 869729003759 transcriptional regulator NarP; Provisional; Region: PRK10403 869729003760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729003761 active site 869729003762 phosphorylation site [posttranslational modification] 869729003763 intermolecular recognition site; other site 869729003764 dimerization interface [polypeptide binding]; other site 869729003765 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869729003766 DNA binding residues [nucleotide binding] 869729003767 dimerization interface [polypeptide binding]; other site 869729003768 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 869729003769 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 869729003770 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 869729003771 Sulfatase; Region: Sulfatase; pfam00884 869729003772 hypothetical protein; Provisional; Region: PRK13689 869729003773 Nucleoid-associated protein [General function prediction only]; Region: COG3081 869729003774 nucleoid-associated protein NdpA; Validated; Region: PRK00378 869729003775 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 869729003776 5S rRNA interface [nucleotide binding]; other site 869729003777 CTC domain interface [polypeptide binding]; other site 869729003778 L16 interface [polypeptide binding]; other site 869729003779 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 869729003780 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869729003781 ATP binding site [chemical binding]; other site 869729003782 putative Mg++ binding site [ion binding]; other site 869729003783 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869729003784 nucleotide binding region [chemical binding]; other site 869729003785 ATP-binding site [chemical binding]; other site 869729003786 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 869729003787 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 869729003788 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869729003789 RNA binding surface [nucleotide binding]; other site 869729003790 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 869729003791 active site 869729003792 uracil binding [chemical binding]; other site 869729003793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729003794 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 869729003795 putative substrate translocation pore; other site 869729003796 hypothetical protein; Provisional; Region: PRK11835 869729003797 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 869729003798 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869729003799 Walker A/P-loop; other site 869729003800 ATP binding site [chemical binding]; other site 869729003801 Q-loop/lid; other site 869729003802 ABC transporter signature motif; other site 869729003803 Walker B; other site 869729003804 D-loop; other site 869729003805 H-loop/switch region; other site 869729003806 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 869729003807 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869729003808 Walker A/P-loop; other site 869729003809 ATP binding site [chemical binding]; other site 869729003810 Q-loop/lid; other site 869729003811 ABC transporter signature motif; other site 869729003812 Walker B; other site 869729003813 D-loop; other site 869729003814 H-loop/switch region; other site 869729003815 microcin C ABC transporter permease; Provisional; Region: PRK15021 869729003816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729003817 dimer interface [polypeptide binding]; other site 869729003818 conserved gate region; other site 869729003819 ABC-ATPase subunit interface; other site 869729003820 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 869729003821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729003822 dimer interface [polypeptide binding]; other site 869729003823 conserved gate region; other site 869729003824 putative PBP binding loops; other site 869729003825 ABC-ATPase subunit interface; other site 869729003826 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 869729003827 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 869729003828 phage resistance protein; Provisional; Region: PRK10551 869729003829 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 869729003830 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 869729003831 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 869729003832 NlpC/P60 family; Region: NLPC_P60; pfam00877 869729003833 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 869729003834 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 869729003835 active site 869729003836 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 869729003837 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 869729003838 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 869729003839 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 869729003840 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 869729003841 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 869729003842 elongation factor P; Provisional; Region: PRK04542 869729003843 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 869729003844 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 869729003845 RNA binding site [nucleotide binding]; other site 869729003846 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 869729003847 RNA binding site [nucleotide binding]; other site 869729003848 Flagellin N-methylase; Region: FliB; pfam03692 869729003849 sugar efflux transporter B; Provisional; Region: PRK15011 869729003850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729003851 putative substrate translocation pore; other site 869729003852 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 869729003853 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869729003854 active site 869729003855 phosphorylation site [posttranslational modification] 869729003856 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 869729003857 dimerization domain swap beta strand [polypeptide binding]; other site 869729003858 regulatory protein interface [polypeptide binding]; other site 869729003859 active site 869729003860 regulatory phosphorylation site [posttranslational modification]; other site 869729003861 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 869729003862 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 869729003863 putative substrate binding site [chemical binding]; other site 869729003864 putative ATP binding site [chemical binding]; other site 869729003865 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 869729003866 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 869729003867 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 869729003868 active site 869729003869 P-loop; other site 869729003870 phosphorylation site [posttranslational modification] 869729003871 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 869729003872 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 869729003873 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 869729003874 substrate binding site [chemical binding]; other site 869729003875 ATP binding site [chemical binding]; other site 869729003876 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 869729003877 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 869729003878 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 869729003879 Nucleoside recognition; Region: Gate; pfam07670 869729003880 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 869729003881 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 869729003882 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 869729003883 ligand binding site [chemical binding]; other site 869729003884 flexible hinge region; other site 869729003885 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 869729003886 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 869729003887 active site 869729003888 tetramer interface [polypeptide binding]; other site 869729003889 putative kinase; Provisional; Region: PRK09954 869729003890 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869729003891 putative DNA binding site [nucleotide binding]; other site 869729003892 putative Zn2+ binding site [ion binding]; other site 869729003893 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 869729003894 substrate binding site [chemical binding]; other site 869729003895 ATP binding site [chemical binding]; other site 869729003896 endonuclease IV; Provisional; Region: PRK01060 869729003897 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 869729003898 AP (apurinic/apyrimidinic) site pocket; other site 869729003899 DNA interaction; other site 869729003900 Metal-binding active site; metal-binding site 869729003901 conserved hypothetical integral membrane protein; Region: TIGR00698 869729003902 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 869729003903 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729003904 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 869729003905 putative dimerization interface [polypeptide binding]; other site 869729003906 lysine transporter; Provisional; Region: PRK10836 869729003907 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 869729003908 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 869729003909 N-terminal plug; other site 869729003910 ligand-binding site [chemical binding]; other site 869729003911 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 869729003912 S-formylglutathione hydrolase; Region: PLN02442 869729003913 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 869729003914 homodecamer interface [polypeptide binding]; other site 869729003915 GTP cyclohydrolase I; Provisional; Region: PLN03044 869729003916 active site 869729003917 putative catalytic site residues [active] 869729003918 zinc binding site [ion binding]; other site 869729003919 GTP-CH-I/GFRP interaction surface; other site 869729003920 Predicted membrane protein [Function unknown]; Region: COG2311 869729003921 hypothetical protein; Provisional; Region: PRK10835 869729003922 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 869729003923 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869729003924 DNA binding site [nucleotide binding] 869729003925 domain linker motif; other site 869729003926 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 869729003927 dimerization interface (closed form) [polypeptide binding]; other site 869729003928 ligand binding site [chemical binding]; other site 869729003929 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 869729003930 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 869729003931 ligand binding site [chemical binding]; other site 869729003932 calcium binding site [ion binding]; other site 869729003933 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 869729003934 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 869729003935 Walker A/P-loop; other site 869729003936 ATP binding site [chemical binding]; other site 869729003937 Q-loop/lid; other site 869729003938 ABC transporter signature motif; other site 869729003939 Walker B; other site 869729003940 D-loop; other site 869729003941 H-loop/switch region; other site 869729003942 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 869729003943 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869729003944 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 869729003945 TM-ABC transporter signature motif; other site 869729003946 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 869729003947 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 869729003948 homodimer interface [polypeptide binding]; other site 869729003949 active site 869729003950 FMN binding site [chemical binding]; other site 869729003951 substrate binding site [chemical binding]; other site 869729003952 4Fe-4S binding domain; Region: Fer4; pfam00037 869729003953 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 869729003954 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 869729003955 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869729003956 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 869729003957 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 869729003958 putative active site [active] 869729003959 cytidine deaminase; Provisional; Region: PRK09027 869729003960 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 869729003961 active site 869729003962 catalytic motif [active] 869729003963 Zn binding site [ion binding]; other site 869729003964 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 869729003965 active site 869729003966 catalytic motif [active] 869729003967 Zn binding site [ion binding]; other site 869729003968 hypothetical protein; Provisional; Region: PRK10711 869729003969 hypothetical protein; Provisional; Region: PRK01821 869729003970 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 869729003971 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 869729003972 FMN binding site [chemical binding]; other site 869729003973 active site 869729003974 catalytic residues [active] 869729003975 substrate binding site [chemical binding]; other site 869729003976 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 869729003977 oxidoreductase; Provisional; Region: PRK12743 869729003978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869729003979 NAD(P) binding site [chemical binding]; other site 869729003980 active site 869729003981 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 869729003982 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 869729003983 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 869729003984 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 869729003985 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 869729003986 D-lactate dehydrogenase; Provisional; Region: PRK11183 869729003987 FAD binding domain; Region: FAD_binding_4; pfam01565 869729003988 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 869729003989 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 869729003990 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 869729003991 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 869729003992 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 869729003993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729003994 dimer interface [polypeptide binding]; other site 869729003995 conserved gate region; other site 869729003996 ABC-ATPase subunit interface; other site 869729003997 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 869729003998 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 869729003999 Walker A/P-loop; other site 869729004000 ATP binding site [chemical binding]; other site 869729004001 Q-loop/lid; other site 869729004002 ABC transporter signature motif; other site 869729004003 Walker B; other site 869729004004 D-loop; other site 869729004005 H-loop/switch region; other site 869729004006 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 869729004007 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 869729004008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729004009 dimer interface [polypeptide binding]; other site 869729004010 conserved gate region; other site 869729004011 putative PBP binding loops; other site 869729004012 ABC-ATPase subunit interface; other site 869729004013 hypothetical protein; Provisional; Region: PRK13681 869729004014 transcriptional regulator MirA; Provisional; Region: PRK15043 869729004015 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 869729004016 DNA binding residues [nucleotide binding] 869729004017 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 869729004018 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 869729004019 GAF domain; Region: GAF; pfam01590 869729004020 Histidine kinase; Region: His_kinase; pfam06580 869729004021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729004022 ATP binding site [chemical binding]; other site 869729004023 Mg2+ binding site [ion binding]; other site 869729004024 G-X-G motif; other site 869729004025 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 869729004026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729004027 active site 869729004028 phosphorylation site [posttranslational modification] 869729004029 intermolecular recognition site; other site 869729004030 dimerization interface [polypeptide binding]; other site 869729004031 LytTr DNA-binding domain; Region: LytTR; pfam04397 869729004032 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 869729004033 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 869729004034 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 869729004035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 869729004036 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 869729004037 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 869729004038 metal ion-dependent adhesion site (MIDAS); other site 869729004039 MoxR-like ATPases [General function prediction only]; Region: COG0714 869729004040 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729004041 Walker A motif; other site 869729004042 ATP binding site [chemical binding]; other site 869729004043 Walker B motif; other site 869729004044 arginine finger; other site 869729004045 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 869729004046 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 869729004047 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 869729004048 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 869729004049 active site 869729004050 HIGH motif; other site 869729004051 KMSKS motif; other site 869729004052 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 869729004053 tRNA binding surface [nucleotide binding]; other site 869729004054 anticodon binding site; other site 869729004055 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 869729004056 dimer interface [polypeptide binding]; other site 869729004057 putative tRNA-binding site [nucleotide binding]; other site 869729004058 antiporter inner membrane protein; Provisional; Region: PRK11670 869729004059 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 869729004060 Walker A motif; other site 869729004061 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 869729004062 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 869729004063 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 869729004064 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 869729004065 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 869729004066 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 869729004067 PapC N-terminal domain; Region: PapC_N; pfam13954 869729004068 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 869729004069 PapC C-terminal domain; Region: PapC_C; pfam13953 869729004070 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 869729004071 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 869729004072 Predicted integral membrane protein [Function unknown]; Region: COG5455 869729004073 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 869729004074 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 869729004075 putative metal binding site [ion binding]; other site 869729004076 putative homodimer interface [polypeptide binding]; other site 869729004077 putative homotetramer interface [polypeptide binding]; other site 869729004078 putative homodimer-homodimer interface [polypeptide binding]; other site 869729004079 putative allosteric switch controlling residues; other site 869729004080 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 869729004081 substrate binding site [chemical binding]; other site 869729004082 multimerization interface [polypeptide binding]; other site 869729004083 ATP binding site [chemical binding]; other site 869729004084 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 869729004085 dimer interface [polypeptide binding]; other site 869729004086 substrate binding site [chemical binding]; other site 869729004087 ATP binding site [chemical binding]; other site 869729004088 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 869729004089 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 869729004090 active site 869729004091 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 869729004092 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869729004093 DNA-binding site [nucleotide binding]; DNA binding site 869729004094 UTRA domain; Region: UTRA; pfam07702 869729004095 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 869729004096 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 869729004097 substrate binding site [chemical binding]; other site 869729004098 ATP binding site [chemical binding]; other site 869729004099 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 869729004100 nucleoside transporter; Region: 2A0110; TIGR00889 869729004101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729004102 putative substrate translocation pore; other site 869729004103 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 869729004104 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 869729004105 putative active site; other site 869729004106 catalytic residue [active] 869729004107 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 869729004108 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 869729004109 intersubunit interface [polypeptide binding]; other site 869729004110 active site 869729004111 zinc binding site [ion binding]; other site 869729004112 Na+ binding site [ion binding]; other site 869729004113 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 869729004114 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869729004115 active site 869729004116 phosphorylation site [posttranslational modification] 869729004117 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 869729004118 active site 869729004119 P-loop; other site 869729004120 phosphorylation site [posttranslational modification] 869729004121 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 869729004122 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 869729004123 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 869729004124 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 869729004125 putative NAD(P) binding site [chemical binding]; other site 869729004126 catalytic Zn binding site [ion binding]; other site 869729004127 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 869729004128 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 869729004129 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869729004130 lipid kinase; Reviewed; Region: PRK13054 869729004131 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 869729004132 putative protease; Provisional; Region: PRK15452 869729004133 Peptidase family U32; Region: Peptidase_U32; pfam01136 869729004134 PcfJ-like protein; Region: PcfJ; pfam14284 869729004135 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 869729004136 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 869729004137 Uncharacterized conserved protein [Function unknown]; Region: COG3422 869729004138 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 869729004139 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 869729004140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729004141 active site 869729004142 phosphorylation site [posttranslational modification] 869729004143 intermolecular recognition site; other site 869729004144 dimerization interface [polypeptide binding]; other site 869729004145 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869729004146 DNA binding site [nucleotide binding] 869729004147 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 869729004148 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869729004149 dimerization interface [polypeptide binding]; other site 869729004150 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869729004151 dimer interface [polypeptide binding]; other site 869729004152 phosphorylation site [posttranslational modification] 869729004153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729004154 ATP binding site [chemical binding]; other site 869729004155 Mg2+ binding site [ion binding]; other site 869729004156 G-X-G motif; other site 869729004157 putative transporter; Provisional; Region: PRK10504 869729004158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729004159 putative substrate translocation pore; other site 869729004160 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 869729004161 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 869729004162 Protein export membrane protein; Region: SecD_SecF; cl14618 869729004163 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 869729004164 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 869729004165 HlyD family secretion protein; Region: HlyD_3; pfam13437 869729004166 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 869729004167 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 869729004168 metal ion-dependent adhesion site (MIDAS); other site 869729004169 Protein phosphatase 2C; Region: PP2C_2; pfam13672 869729004170 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 869729004171 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 869729004172 substrate binding site [chemical binding]; other site 869729004173 activation loop (A-loop); other site 869729004174 Y-family of DNA polymerases; Region: PolY; cl12025 869729004175 putative chaperone; Provisional; Region: PRK11678 869729004176 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 869729004177 nucleotide binding site [chemical binding]; other site 869729004178 putative NEF/HSP70 interaction site [polypeptide binding]; other site 869729004179 SBD interface [polypeptide binding]; other site 869729004180 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 869729004181 AlkA N-terminal domain; Region: AlkA_N; smart01009 869729004182 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 869729004183 minor groove reading motif; other site 869729004184 helix-hairpin-helix signature motif; other site 869729004185 substrate binding pocket [chemical binding]; other site 869729004186 active site 869729004187 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 869729004188 putative diguanylate cyclase; Provisional; Region: PRK09776 869729004189 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869729004190 putative active site [active] 869729004191 heme pocket [chemical binding]; other site 869729004192 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869729004193 putative active site [active] 869729004194 heme pocket [chemical binding]; other site 869729004195 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869729004196 putative active site [active] 869729004197 heme pocket [chemical binding]; other site 869729004198 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 869729004199 metal binding site [ion binding]; metal-binding site 869729004200 active site 869729004201 I-site; other site 869729004202 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 869729004203 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 869729004204 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 869729004205 ATP-binding site [chemical binding]; other site 869729004206 Sugar specificity; other site 869729004207 Pyrimidine base specificity; other site 869729004208 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 869729004209 trimer interface [polypeptide binding]; other site 869729004210 active site 869729004211 putative assembly protein; Provisional; Region: PRK10833 869729004212 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 869729004213 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 869729004214 Phage-related protein [Function unknown]; Region: COG4679 869729004215 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 869729004216 FOG: CBS domain [General function prediction only]; Region: COG0517 869729004217 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 869729004218 Transporter associated domain; Region: CorC_HlyC; smart01091 869729004219 polysaccharide export protein Wza; Provisional; Region: PRK15078 869729004220 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 869729004221 SLBB domain; Region: SLBB; pfam10531 869729004222 Low molecular weight phosphatase family; Region: LMWPc; cd00115 869729004223 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 869729004224 active site 869729004225 tyrosine kinase; Provisional; Region: PRK11519 869729004226 Chain length determinant protein; Region: Wzz; pfam02706 869729004227 Chain length determinant protein; Region: Wzz; cl15801 869729004228 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 869729004229 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 869729004230 putative glycosyl transferase; Provisional; Region: PRK10018 869729004231 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 869729004232 active site 869729004233 putative acyl transferase; Provisional; Region: PRK10191 869729004234 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 869729004235 trimer interface [polypeptide binding]; other site 869729004236 active site 869729004237 substrate binding site [chemical binding]; other site 869729004238 CoA binding site [chemical binding]; other site 869729004239 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 869729004240 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 869729004241 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 869729004242 putative glycosyl transferase; Provisional; Region: PRK10063 869729004243 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 869729004244 metal-binding site 869729004245 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 869729004246 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 869729004247 putative trimer interface [polypeptide binding]; other site 869729004248 putative active site [active] 869729004249 putative substrate binding site [chemical binding]; other site 869729004250 putative CoA binding site [chemical binding]; other site 869729004251 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 869729004252 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 869729004253 NADP-binding site; other site 869729004254 homotetramer interface [polypeptide binding]; other site 869729004255 substrate binding site [chemical binding]; other site 869729004256 homodimer interface [polypeptide binding]; other site 869729004257 active site 869729004258 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 869729004259 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 869729004260 NADP binding site [chemical binding]; other site 869729004261 active site 869729004262 putative substrate binding site [chemical binding]; other site 869729004263 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 869729004264 active site 869729004265 GDP-Mannose binding site [chemical binding]; other site 869729004266 dimer interface [polypeptide binding]; other site 869729004267 modified nudix motif 869729004268 metal binding site [ion binding]; metal-binding site 869729004269 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 869729004270 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 869729004271 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 869729004272 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 869729004273 Substrate binding site; other site 869729004274 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 869729004275 phosphomannomutase CpsG; Provisional; Region: PRK15414 869729004276 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 869729004277 active site 869729004278 substrate binding site [chemical binding]; other site 869729004279 metal binding site [ion binding]; metal-binding site 869729004280 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 869729004281 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 869729004282 colanic acid exporter; Provisional; Region: PRK10459 869729004283 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 869729004284 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 869729004285 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 869729004286 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 869729004287 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 869729004288 putative ADP-binding pocket [chemical binding]; other site 869729004289 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 869729004290 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 869729004291 active site 869729004292 tetramer interface; other site 869729004293 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 869729004294 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 869729004295 NAD binding site [chemical binding]; other site 869729004296 substrate binding site [chemical binding]; other site 869729004297 homodimer interface [polypeptide binding]; other site 869729004298 active site 869729004299 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 869729004300 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 869729004301 NADP binding site [chemical binding]; other site 869729004302 active site 869729004303 putative substrate binding site [chemical binding]; other site 869729004304 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 869729004305 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 869729004306 substrate binding site; other site 869729004307 tetramer interface; other site 869729004308 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 869729004309 potential frameshift: common BLAST hit: gi|110806006|ref|YP_689526.1| polysaccharide biosynthesis protein 869729004310 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 869729004311 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 869729004312 active site 869729004313 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 869729004314 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 869729004315 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 869729004316 active site 869729004317 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869729004318 This family is most closely related to the GT1 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor...; Region: GT1_WbdM_like; cd04951 869729004319 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869729004320 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 869729004321 putative ADP-binding pocket [chemical binding]; other site 869729004322 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 869729004323 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 869729004324 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 869729004325 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 869729004326 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 869729004327 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 869729004328 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 869729004329 chain length determinant protein WzzB; Provisional; Region: PRK15471 869729004330 Chain length determinant protein; Region: Wzz; pfam02706 869729004331 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 869729004332 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 869729004333 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 869729004334 metal binding site [ion binding]; metal-binding site 869729004335 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 869729004336 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 869729004337 substrate binding site [chemical binding]; other site 869729004338 glutamase interaction surface [polypeptide binding]; other site 869729004339 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 869729004340 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 869729004341 catalytic residues [active] 869729004342 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 869729004343 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 869729004344 putative active site [active] 869729004345 oxyanion strand; other site 869729004346 catalytic triad [active] 869729004347 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 869729004348 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869729004349 active site 869729004350 motif I; other site 869729004351 motif II; other site 869729004352 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 869729004353 putative active site pocket [active] 869729004354 4-fold oligomerization interface [polypeptide binding]; other site 869729004355 metal binding residues [ion binding]; metal-binding site 869729004356 3-fold/trimer interface [polypeptide binding]; other site 869729004357 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 869729004358 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869729004359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729004360 homodimer interface [polypeptide binding]; other site 869729004361 catalytic residue [active] 869729004362 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 869729004363 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 869729004364 NAD binding site [chemical binding]; other site 869729004365 dimerization interface [polypeptide binding]; other site 869729004366 product binding site; other site 869729004367 substrate binding site [chemical binding]; other site 869729004368 zinc binding site [ion binding]; other site 869729004369 catalytic residues [active] 869729004370 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 869729004371 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 869729004372 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 869729004373 antitoxin YefM; Provisional; Region: PRK11409 869729004374 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 869729004375 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 869729004376 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 869729004377 putative NAD(P) binding site [chemical binding]; other site 869729004378 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729004379 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 869729004380 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 869729004381 dimerization interface [polypeptide binding]; other site 869729004382 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 869729004383 exonuclease I; Provisional; Region: sbcB; PRK11779 869729004384 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 869729004385 active site 869729004386 catalytic site [active] 869729004387 substrate binding site [chemical binding]; other site 869729004388 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 869729004389 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 869729004390 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 869729004391 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 869729004392 DNA gyrase inhibitor; Provisional; Region: PRK10016 869729004393 Predicted membrane protein [Function unknown]; Region: COG1289 869729004394 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 869729004395 hypothetical protein; Provisional; Region: PRK05423 869729004396 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 869729004397 Switch II region; other site 869729004398 G4 box; other site 869729004399 G5 box; other site 869729004400 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 869729004401 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 869729004402 Protein of unknown function (DUF987); Region: DUF987; pfam06174 869729004403 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 869729004404 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 869729004405 MPN+ (JAMM) motif; other site 869729004406 Zinc-binding site [ion binding]; other site 869729004407 Antirestriction protein; Region: Antirestrict; pfam03230 869729004408 Domain of unknown function (DUF932); Region: DUF932; pfam06067 869729004409 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 869729004410 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 869729004411 nucleophile elbow; other site 869729004412 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 869729004413 YjcZ-like protein; Region: YjcZ; pfam13990 869729004414 hypothetical protein; Provisional; Region: PRK09866 869729004415 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 869729004416 G1 box; other site 869729004417 GTP/Mg2+ binding site [chemical binding]; other site 869729004418 G2 box; other site 869729004419 Switch I region; other site 869729004420 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 869729004421 G3 box; other site 869729004422 Switch II region; other site 869729004423 GTP/Mg2+ binding site [chemical binding]; other site 869729004424 G4 box; other site 869729004425 G5 box; other site 869729004426 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 869729004427 G1 box; other site 869729004428 GTP/Mg2+ binding site [chemical binding]; other site 869729004429 G2 box; other site 869729004430 Switch I region; other site 869729004431 Switch II region; other site 869729004432 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 869729004433 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 869729004434 N-terminal plug; other site 869729004435 ligand-binding site [chemical binding]; other site 869729004436 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 869729004437 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 869729004438 putative ligand binding residues [chemical binding]; other site 869729004439 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869729004440 dimer interface [polypeptide binding]; other site 869729004441 putative PBP binding regions; other site 869729004442 ABC-ATPase subunit interface; other site 869729004443 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 869729004444 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 869729004445 Walker A/P-loop; other site 869729004446 ATP binding site [chemical binding]; other site 869729004447 Q-loop/lid; other site 869729004448 ABC transporter signature motif; other site 869729004449 Walker B; other site 869729004450 D-loop; other site 869729004451 H-loop/switch region; other site 869729004452 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 869729004453 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 869729004454 DNA-binding interface [nucleotide binding]; DNA binding site 869729004455 Integrase core domain; Region: rve; pfam00665 869729004456 transposase/IS protein; Provisional; Region: PRK09183 869729004457 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729004458 Walker A motif; other site 869729004459 ATP binding site [chemical binding]; other site 869729004460 Walker B motif; other site 869729004461 3-oxoacyl-(acyl carrier protein) synthase II; Provisional; Region: PRK14691 869729004462 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 869729004463 Transposase; Region: DEDD_Tnp_IS110; pfam01548 869729004464 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 869729004465 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 869729004466 Haemolysin expression modulating protein; Region: HHA; cl11501 869729004467 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 869729004468 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 869729004469 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 869729004470 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 869729004471 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 869729004472 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 869729004473 Transposase; Region: DDE_Tnp_ISL3; pfam01610 869729004474 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 869729004475 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 869729004476 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 869729004477 active site 869729004478 substrate binding pocket [chemical binding]; other site 869729004479 homodimer interaction site [polypeptide binding]; other site 869729004480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 869729004481 Protein of unknown function, DUF606; Region: DUF606; pfam04657 869729004482 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 869729004483 potential frameshift: common BLAST hit: gi|218699429|ref|YP_002407058.1| putative carbohydrate kinase 869729004484 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 869729004485 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 869729004486 Transposase; Region: DEDD_Tnp_IS110; pfam01548 869729004487 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 869729004488 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 869729004489 putative trimer interface [polypeptide binding]; other site 869729004490 putative CoA binding site [chemical binding]; other site 869729004491 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 869729004492 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 869729004493 DXD motif; other site 869729004494 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 869729004495 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 869729004496 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 869729004497 Active Sites [active] 869729004498 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 869729004499 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 869729004500 ParB-like nuclease domain; Region: ParBc; cl02129 869729004501 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 869729004502 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 869729004503 N-terminal plug; other site 869729004504 ligand-binding site [chemical binding]; other site 869729004505 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 869729004506 homotrimer interface [polypeptide binding]; other site 869729004507 Walker A motif; other site 869729004508 GTP binding site [chemical binding]; other site 869729004509 Walker B motif; other site 869729004510 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 869729004511 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 869729004512 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 869729004513 putative dimer interface [polypeptide binding]; other site 869729004514 active site pocket [active] 869729004515 putative cataytic base [active] 869729004516 L,D-transpeptidase; Provisional; Region: PRK10190 869729004517 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 869729004518 Integrase core domain; Region: rve_2; pfam13333 869729004519 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 869729004520 Integrase core domain; Region: rve; pfam00665 869729004521 Integrase core domain; Region: rve_3; pfam13683 869729004522 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 869729004523 DNA-binding interface [nucleotide binding]; DNA binding site 869729004524 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 869729004525 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 869729004526 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869729004527 DNA binding residues [nucleotide binding] 869729004528 dimerization interface [polypeptide binding]; other site 869729004529 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 869729004530 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 869729004531 acyl-activating enzyme (AAE) consensus motif; other site 869729004532 AMP binding site [chemical binding]; other site 869729004533 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 869729004534 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 869729004535 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 869729004536 active site 869729004537 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 869729004538 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 869729004539 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 869729004540 KR domain; Region: KR; pfam08659 869729004541 putative NADP binding site [chemical binding]; other site 869729004542 active site 869729004543 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 869729004544 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 869729004545 Enoylreductase; Region: PKS_ER; smart00829 869729004546 NAD(P) binding site [chemical binding]; other site 869729004547 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 869729004548 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 869729004549 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 869729004550 active site 869729004551 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 869729004552 potential frameshift: common BLAST hit: gi|110642147|ref|YP_669877.1| 3-hydroxybutyryl-CoA dehydrogenase 869729004553 acyl carrier protein; Provisional; Region: PRK07081 869729004554 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 869729004555 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 869729004556 active site 869729004557 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 869729004558 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 869729004559 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 869729004560 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 869729004561 acyl-activating enzyme (AAE) consensus motif; other site 869729004562 AMP binding site [chemical binding]; other site 869729004563 Condensation domain; Region: Condensation; pfam00668 869729004564 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 869729004565 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 869729004566 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 869729004567 acyl-activating enzyme (AAE) consensus motif; other site 869729004568 AMP binding site [chemical binding]; other site 869729004569 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 869729004570 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 869729004571 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 869729004572 active site 869729004573 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 869729004574 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 869729004575 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 869729004576 Condensation domain; Region: Condensation; pfam00668 869729004577 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 869729004578 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 869729004579 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 869729004580 acyl-activating enzyme (AAE) consensus motif; other site 869729004581 AMP binding site [chemical binding]; other site 869729004582 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 869729004583 Condensation domain; Region: Condensation; pfam00668 869729004584 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 869729004585 Nonribosomal peptide synthase; Region: NRPS; pfam08415 869729004586 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 869729004587 acyl-activating enzyme (AAE) consensus motif; other site 869729004588 AMP binding site [chemical binding]; other site 869729004589 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 869729004590 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 869729004591 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 869729004592 active site 869729004593 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 869729004594 Condensation domain; Region: Condensation; pfam00668 869729004595 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 869729004596 Nonribosomal peptide synthase; Region: NRPS; pfam08415 869729004597 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 869729004598 acyl-activating enzyme (AAE) consensus motif; other site 869729004599 AMP binding site [chemical binding]; other site 869729004600 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 869729004601 putative FMN binding site [chemical binding]; other site 869729004602 NADPH bind site [chemical binding]; other site 869729004603 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 869729004604 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 869729004605 amidase; Provisional; Region: PRK06170 869729004606 Amidase; Region: Amidase; cl11426 869729004607 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_6; cd13146 869729004608 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 869729004609 Condensation domain; Region: Condensation; pfam00668 869729004610 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 869729004611 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 869729004612 acyl-activating enzyme (AAE) consensus motif; other site 869729004613 AMP binding site [chemical binding]; other site 869729004614 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 869729004615 Condensation domain; Region: Condensation; pfam00668 869729004616 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 869729004617 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 869729004618 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 869729004619 active site 869729004620 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 869729004621 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 869729004622 integrase; Provisional; Region: PRK09692 869729004623 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 869729004624 active site 869729004625 Int/Topo IB signature motif; other site 869729004626 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 869729004627 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 869729004628 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729004629 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 869729004630 putative dimerization interface [polypeptide binding]; other site 869729004631 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 869729004632 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729004633 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 869729004634 putative substrate binding site [chemical binding]; other site 869729004635 dimerization interface [polypeptide binding]; other site 869729004636 MATE family multidrug exporter; Provisional; Region: PRK10189 869729004637 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 869729004638 hypothetical protein; Provisional; Region: PRK12378 869729004639 AMP nucleosidase; Provisional; Region: PRK08292 869729004640 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 869729004641 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 869729004642 shikimate transporter; Provisional; Region: PRK09952 869729004643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729004644 putative substrate translocation pore; other site 869729004645 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 869729004646 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 869729004647 potential frameshift: common BLAST hit: gi|117624169|ref|YP_853082.1| putative autotransporter 869729004648 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 869729004649 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 869729004650 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 869729004651 N-terminal plug; other site 869729004652 ligand-binding site [chemical binding]; other site 869729004653 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 869729004654 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 869729004655 acyl-activating enzyme (AAE) consensus motif; other site 869729004656 active site 869729004657 AMP binding site [chemical binding]; other site 869729004658 substrate binding site [chemical binding]; other site 869729004659 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 869729004660 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 869729004661 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 869729004662 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 869729004663 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 869729004664 active site 869729004665 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 869729004666 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 869729004667 Methyltransferase domain; Region: Methyltransf_12; pfam08242 869729004668 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 869729004669 KR domain; Region: KR; pfam08659 869729004670 NADP binding site [chemical binding]; other site 869729004671 active site 869729004672 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 869729004673 Condensation domain; Region: Condensation; pfam00668 869729004674 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 869729004675 Nonribosomal peptide synthase; Region: NRPS; pfam08415 869729004676 Methyltransferase domain; Region: Methyltransf_12; pfam08242 869729004677 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 869729004678 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 869729004679 Condensation domain; Region: Condensation; pfam00668 869729004680 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 869729004681 Nonribosomal peptide synthase; Region: NRPS; pfam08415 869729004682 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 869729004683 acyl-activating enzyme (AAE) consensus motif; other site 869729004684 AMP binding site [chemical binding]; other site 869729004685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729004686 S-adenosylmethionine binding site [chemical binding]; other site 869729004687 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 869729004688 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 869729004689 Condensation domain; Region: Condensation; pfam00668 869729004690 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 869729004691 Nonribosomal peptide synthase; Region: NRPS; pfam08415 869729004692 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 869729004693 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 869729004694 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 869729004695 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729004696 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869729004697 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869729004698 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869729004699 Walker A/P-loop; other site 869729004700 ATP binding site [chemical binding]; other site 869729004701 Q-loop/lid; other site 869729004702 ABC transporter signature motif; other site 869729004703 Walker B; other site 869729004704 D-loop; other site 869729004705 H-loop/switch region; other site 869729004706 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869729004707 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869729004708 Walker A/P-loop; other site 869729004709 ATP binding site [chemical binding]; other site 869729004710 Q-loop/lid; other site 869729004711 ABC transporter signature motif; other site 869729004712 Walker B; other site 869729004713 D-loop; other site 869729004714 H-loop/switch region; other site 869729004715 muropeptide transporter; Validated; Region: ampG; cl17669 869729004716 salicylate synthase Irp9; Reviewed; Region: PRK06772 869729004717 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 869729004718 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 869729004719 active site 869729004720 Int/Topo IB signature motif; other site 869729004721 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 869729004722 zinc/cadmium-binding protein; Provisional; Region: PRK10306 869729004723 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 869729004724 TMAO/DMSO reductase; Reviewed; Region: PRK05363 869729004725 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 869729004726 Moco binding site; other site 869729004727 metal coordination site [ion binding]; other site 869729004728 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 869729004729 active site 869729004730 homotetramer interface [polypeptide binding]; other site 869729004731 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 869729004732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729004733 active site 869729004734 phosphorylation site [posttranslational modification] 869729004735 intermolecular recognition site; other site 869729004736 dimerization interface [polypeptide binding]; other site 869729004737 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869729004738 DNA binding site [nucleotide binding] 869729004739 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 869729004740 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869729004741 dimer interface [polypeptide binding]; other site 869729004742 phosphorylation site [posttranslational modification] 869729004743 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729004744 ATP binding site [chemical binding]; other site 869729004745 Mg2+ binding site [ion binding]; other site 869729004746 G-X-G motif; other site 869729004747 chaperone protein HchA; Provisional; Region: PRK04155 869729004748 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 869729004749 dimer interface [polypeptide binding]; other site 869729004750 metal binding site [ion binding]; metal-binding site 869729004751 potential oxyanion hole; other site 869729004752 potential catalytic triad [active] 869729004753 conserved cys residue [active] 869729004754 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 869729004755 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 869729004756 eyelet of channel; other site 869729004757 trimer interface [polypeptide binding]; other site 869729004758 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 869729004759 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 869729004760 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869729004761 Zn2+ binding site [ion binding]; other site 869729004762 Mg2+ binding site [ion binding]; other site 869729004763 DNA cytosine methylase; Provisional; Region: PRK10458 869729004764 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 869729004765 cofactor binding site; other site 869729004766 DNA binding site [nucleotide binding] 869729004767 substrate interaction site [chemical binding]; other site 869729004768 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 869729004769 additional DNA contacts [nucleotide binding]; other site 869729004770 mismatch recognition site; other site 869729004771 active site 869729004772 zinc binding site [ion binding]; other site 869729004773 DNA intercalation site [nucleotide binding]; other site 869729004774 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 869729004775 EamA-like transporter family; Region: EamA; pfam00892 869729004776 hypothetical protein; Provisional; Region: PRK10062 869729004777 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 869729004778 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 869729004779 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 869729004780 metal binding site [ion binding]; metal-binding site 869729004781 active site 869729004782 I-site; other site 869729004783 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 869729004784 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869729004785 active site 869729004786 motif I; other site 869729004787 motif II; other site 869729004788 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 869729004789 hypothetical protein; Provisional; Region: PRK10708 869729004790 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 869729004791 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869729004792 DNA binding residues [nucleotide binding] 869729004793 dimerization interface [polypeptide binding]; other site 869729004794 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 869729004795 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 869729004796 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 869729004797 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 869729004798 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 869729004799 flagellar motor switch protein; Validated; Region: fliN; PRK05698 869729004800 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 869729004801 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 869729004802 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 869729004803 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 869729004804 flagellar hook-length control protein; Provisional; Region: PRK10118 869729004805 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 869729004806 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 869729004807 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 869729004808 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 869729004809 Walker A motif/ATP binding site; other site 869729004810 Walker B motif; other site 869729004811 flagellar assembly protein H; Validated; Region: fliH; PRK05687 869729004812 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 869729004813 Flagellar assembly protein FliH; Region: FliH; pfam02108 869729004814 flagellar motor switch protein FliG; Region: fliG; TIGR00207 869729004815 FliG C-terminal domain; Region: FliG_C; pfam01706 869729004816 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 869729004817 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 869729004818 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 869729004819 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 869729004820 multidrug efflux protein; Reviewed; Region: emrE; PRK09541 869729004821 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 869729004822 substrate binding site [chemical binding]; other site 869729004823 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 869729004824 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 869729004825 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 869729004826 trimer interface [polypeptide binding]; other site 869729004827 eyelet of channel; other site 869729004828 hypothetical protein; Provisional; Region: PRK09951 869729004829 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 869729004830 CPxP motif; other site 869729004831 putative inner membrane protein; Provisional; Region: PRK11099 869729004832 lipoprotein; Provisional; Region: PRK10397 869729004833 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 869729004834 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 869729004835 active site 869729004836 Na/Ca binding site [ion binding]; other site 869729004837 catalytic site [active] 869729004838 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 869729004839 Flagellar protein FliS; Region: FliS; cl00654 869729004840 flagellar capping protein; Reviewed; Region: fliD; PRK08032 869729004841 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 869729004842 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 869729004843 flagellin; Validated; Region: PRK08026 869729004844 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 869729004845 Flagellin protein; Region: FliC; pfam12445 869729004846 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 869729004847 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 869729004848 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 869729004849 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 869729004850 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 869729004851 DNA binding residues [nucleotide binding] 869729004852 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 869729004853 cystine transporter subunit; Provisional; Region: PRK11260 869729004854 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869729004855 substrate binding pocket [chemical binding]; other site 869729004856 membrane-bound complex binding site; other site 869729004857 hinge residues; other site 869729004858 D-cysteine desulfhydrase; Validated; Region: PRK03910 869729004859 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 869729004860 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729004861 catalytic residue [active] 869729004862 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 869729004863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729004864 dimer interface [polypeptide binding]; other site 869729004865 conserved gate region; other site 869729004866 putative PBP binding loops; other site 869729004867 ABC-ATPase subunit interface; other site 869729004868 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 869729004869 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 869729004870 Walker A/P-loop; other site 869729004871 ATP binding site [chemical binding]; other site 869729004872 Q-loop/lid; other site 869729004873 ABC transporter signature motif; other site 869729004874 Walker B; other site 869729004875 D-loop; other site 869729004876 H-loop/switch region; other site 869729004877 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 869729004878 Autoinducer binding domain; Region: Autoind_bind; pfam03472 869729004879 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869729004880 DNA binding residues [nucleotide binding] 869729004881 dimerization interface [polypeptide binding]; other site 869729004882 hypothetical protein; Provisional; Region: PRK10613 869729004883 response regulator; Provisional; Region: PRK09483 869729004884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729004885 active site 869729004886 phosphorylation site [posttranslational modification] 869729004887 intermolecular recognition site; other site 869729004888 dimerization interface [polypeptide binding]; other site 869729004889 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869729004890 DNA binding residues [nucleotide binding] 869729004891 dimerization interface [polypeptide binding]; other site 869729004892 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 869729004893 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 869729004894 GIY-YIG motif/motif A; other site 869729004895 active site 869729004896 catalytic site [active] 869729004897 putative DNA binding site [nucleotide binding]; other site 869729004898 metal binding site [ion binding]; metal-binding site 869729004899 UvrB/uvrC motif; Region: UVR; pfam02151 869729004900 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 869729004901 Helix-hairpin-helix motif; Region: HHH; pfam00633 869729004902 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 869729004903 hypothetical protein; Provisional; Region: PRK10396 869729004904 yecA family protein; Region: ygfB_yecA; TIGR02292 869729004905 SEC-C motif; Region: SEC-C; pfam02810 869729004906 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 869729004907 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 869729004908 probable metal-binding protein; Region: matur_matur; TIGR03853 869729004909 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 869729004910 Ferritin-like domain; Region: Ferritin; pfam00210 869729004911 ferroxidase diiron center [ion binding]; other site 869729004912 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 869729004913 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 869729004914 Ferritin-like domain; Region: Ferritin; pfam00210 869729004915 ferroxidase diiron center [ion binding]; other site 869729004916 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 869729004917 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 869729004918 ligand binding site [chemical binding]; other site 869729004919 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 869729004920 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 869729004921 Walker A/P-loop; other site 869729004922 ATP binding site [chemical binding]; other site 869729004923 Q-loop/lid; other site 869729004924 ABC transporter signature motif; other site 869729004925 Walker B; other site 869729004926 D-loop; other site 869729004927 H-loop/switch region; other site 869729004928 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 869729004929 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 869729004930 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869729004931 TM-ABC transporter signature motif; other site 869729004932 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 869729004933 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 869729004934 active site 869729004935 homotetramer interface [polypeptide binding]; other site 869729004936 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 869729004937 Ligand Binding Site [chemical binding]; other site 869729004938 transcriptional activator FlhD; Provisional; Region: PRK02909 869729004939 transcriptional activator FlhC; Provisional; Region: PRK12722 869729004940 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 869729004941 flagellar motor protein MotA; Validated; Region: PRK09110 869729004942 flagellar motor protein MotB; Validated; Region: motB; PRK09041 869729004943 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 869729004944 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 869729004945 ligand binding site [chemical binding]; other site 869729004946 chemotaxis protein CheA; Provisional; Region: PRK10547 869729004947 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 869729004948 putative binding surface; other site 869729004949 active site 869729004950 CheY binding; Region: CheY-binding; pfam09078 869729004951 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 869729004952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729004953 ATP binding site [chemical binding]; other site 869729004954 Mg2+ binding site [ion binding]; other site 869729004955 G-X-G motif; other site 869729004956 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 869729004957 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 869729004958 putative CheA interaction surface; other site 869729004959 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 869729004960 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 869729004961 dimer interface [polypeptide binding]; other site 869729004962 ligand binding site [chemical binding]; other site 869729004963 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869729004964 dimerization interface [polypeptide binding]; other site 869729004965 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 869729004966 dimer interface [polypeptide binding]; other site 869729004967 putative CheW interface [polypeptide binding]; other site 869729004968 methyl-accepting protein IV; Provisional; Region: PRK09793 869729004969 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 869729004970 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 869729004971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729004972 S-adenosylmethionine binding site [chemical binding]; other site 869729004973 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 869729004974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729004975 active site 869729004976 phosphorylation site [posttranslational modification] 869729004977 intermolecular recognition site; other site 869729004978 dimerization interface [polypeptide binding]; other site 869729004979 CheB methylesterase; Region: CheB_methylest; pfam01339 869729004980 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 869729004981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729004982 active site 869729004983 phosphorylation site [posttranslational modification] 869729004984 intermolecular recognition site; other site 869729004985 dimerization interface [polypeptide binding]; other site 869729004986 chemotaxis regulator CheZ; Provisional; Region: PRK11166 869729004987 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 869729004988 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 869729004989 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 869729004990 FHIPEP family; Region: FHIPEP; pfam00771 869729004991 Flagellar protein FlhE; Region: FlhE; pfam06366 869729004992 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 869729004993 arginyl-tRNA synthetase; Region: argS; TIGR00456 869729004994 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 869729004995 active site 869729004996 HIGH motif; other site 869729004997 KMSK motif region; other site 869729004998 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 869729004999 tRNA binding surface [nucleotide binding]; other site 869729005000 anticodon binding site; other site 869729005001 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 869729005002 putative metal binding site [ion binding]; other site 869729005003 copper homeostasis protein CutC; Provisional; Region: PRK11572 869729005004 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 869729005005 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 869729005006 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 869729005007 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 869729005008 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 869729005009 molybdopterin cofactor binding site [chemical binding]; other site 869729005010 substrate binding site [chemical binding]; other site 869729005011 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 869729005012 molybdopterin cofactor binding site; other site 869729005013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729005014 S-adenosylmethionine binding site [chemical binding]; other site 869729005015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729005016 S-adenosylmethionine binding site [chemical binding]; other site 869729005017 hypothetical protein; Provisional; Region: PRK10302 869729005018 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 869729005019 Isochorismatase family; Region: Isochorismatase; pfam00857 869729005020 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 869729005021 catalytic triad [active] 869729005022 conserved cis-peptide bond; other site 869729005023 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 869729005024 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 869729005025 dimer interface [polypeptide binding]; other site 869729005026 anticodon binding site; other site 869729005027 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 869729005028 homodimer interface [polypeptide binding]; other site 869729005029 motif 1; other site 869729005030 active site 869729005031 motif 2; other site 869729005032 GAD domain; Region: GAD; pfam02938 869729005033 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 869729005034 motif 3; other site 869729005035 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 869729005036 nudix motif; other site 869729005037 hypothetical protein; Validated; Region: PRK00110 869729005038 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 869729005039 active site 869729005040 putative DNA-binding cleft [nucleotide binding]; other site 869729005041 dimer interface [polypeptide binding]; other site 869729005042 hypothetical protein; Provisional; Region: PRK11470 869729005043 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 869729005044 RuvA N terminal domain; Region: RuvA_N; pfam01330 869729005045 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 869729005046 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 869729005047 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729005048 Walker A motif; other site 869729005049 ATP binding site [chemical binding]; other site 869729005050 Walker B motif; other site 869729005051 arginine finger; other site 869729005052 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 869729005053 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 869729005054 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869729005055 ABC-ATPase subunit interface; other site 869729005056 dimer interface [polypeptide binding]; other site 869729005057 putative PBP binding regions; other site 869729005058 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 869729005059 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 869729005060 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 869729005061 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 869729005062 metal binding site [ion binding]; metal-binding site 869729005063 putative peptidase; Provisional; Region: PRK11649 869729005064 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 869729005065 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869729005066 Peptidase family M23; Region: Peptidase_M23; pfam01551 869729005067 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 869729005068 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 869729005069 putative acyl-acceptor binding pocket; other site 869729005070 pyruvate kinase; Provisional; Region: PRK05826 869729005071 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 869729005072 domain interfaces; other site 869729005073 active site 869729005074 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 869729005075 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 869729005076 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 869729005077 putative active site [active] 869729005078 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 869729005079 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 869729005080 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 869729005081 phosphogluconate dehydratase; Validated; Region: PRK09054 869729005082 6-phosphogluconate dehydratase; Region: edd; TIGR01196 869729005083 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 869729005084 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 869729005085 active site 869729005086 intersubunit interface [polypeptide binding]; other site 869729005087 catalytic residue [active] 869729005088 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 869729005089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869729005090 ATP-grasp domain; Region: ATP-grasp; pfam02222 869729005091 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 869729005092 hypothetical protein; Provisional; Region: PRK13680 869729005093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 869729005094 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 869729005095 putative metal binding site [ion binding]; other site 869729005096 protease 2; Provisional; Region: PRK10115 869729005097 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 869729005098 exodeoxyribonuclease X; Provisional; Region: PRK07983 869729005099 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 869729005100 active site 869729005101 catalytic site [active] 869729005102 substrate binding site [chemical binding]; other site 869729005103 Predicted amidohydrolase [General function prediction only]; Region: COG0388 869729005104 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 869729005105 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 869729005106 hypothetical protein; Provisional; Region: PRK10301 869729005107 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 869729005108 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 869729005109 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 869729005110 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 869729005111 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 869729005112 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 869729005113 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 869729005114 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 869729005115 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 869729005116 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 869729005117 mce related protein; Region: MCE; pfam02470 869729005118 mce related protein; Region: MCE; pfam02470 869729005119 mce related protein; Region: MCE; pfam02470 869729005120 mce related protein; Region: MCE; pfam02470 869729005121 mce related protein; Region: MCE; pfam02470 869729005122 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 869729005123 Paraquat-inducible protein A; Region: PqiA; pfam04403 869729005124 Paraquat-inducible protein A; Region: PqiA; pfam04403 869729005125 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 869729005126 GAF domain; Region: GAF_2; pfam13185 869729005127 ProP expression regulator; Provisional; Region: PRK04950 869729005128 ProQ/FINO family; Region: ProQ; pfam04352 869729005129 carboxy-terminal protease; Provisional; Region: PRK11186 869729005130 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 869729005131 protein binding site [polypeptide binding]; other site 869729005132 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 869729005133 Catalytic dyad [active] 869729005134 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 869729005135 heat shock protein HtpX; Provisional; Region: PRK05457 869729005136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729005137 Major Facilitator Superfamily; Region: MFS_1; pfam07690 869729005138 putative substrate translocation pore; other site 869729005139 Predicted integral membrane protein [Function unknown]; Region: COG5521 869729005140 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 869729005141 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869729005142 dimerization interface [polypeptide binding]; other site 869729005143 putative Zn2+ binding site [ion binding]; other site 869729005144 putative DNA binding site [nucleotide binding]; other site 869729005145 Bacterial transcriptional regulator; Region: IclR; pfam01614 869729005146 YobH-like protein; Region: YobH; pfam13996 869729005147 PhoPQ regulatory protein; Provisional; Region: PRK10299 869729005148 YebO-like protein; Region: YebO; pfam13974 869729005149 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 869729005150 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 869729005151 DNA-binding site [nucleotide binding]; DNA binding site 869729005152 RNA-binding motif; other site 869729005153 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 869729005154 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729005155 S-adenosylmethionine binding site [chemical binding]; other site 869729005156 hypothetical protein; Provisional; Region: PRK11469 869729005157 Domain of unknown function DUF; Region: DUF204; pfam02659 869729005158 Domain of unknown function DUF; Region: DUF204; pfam02659 869729005159 Predicted membrane protein [Function unknown]; Region: COG4811 869729005160 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 869729005161 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 869729005162 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 869729005163 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 869729005164 active pocket/dimerization site; other site 869729005165 active site 869729005166 phosphorylation site [posttranslational modification] 869729005167 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 869729005168 active site 869729005169 phosphorylation site [posttranslational modification] 869729005170 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 869729005171 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 869729005172 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 869729005173 Transporter associated domain; Region: CorC_HlyC; smart01091 869729005174 phage resistance protein; Provisional; Region: PRK10551 869729005175 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 869729005176 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 869729005177 L-serine deaminase; Provisional; Region: PRK15023 869729005178 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 869729005179 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 869729005180 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 869729005181 putative active site [active] 869729005182 putative CoA binding site [chemical binding]; other site 869729005183 nudix motif; other site 869729005184 metal binding site [ion binding]; metal-binding site 869729005185 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 869729005186 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 869729005187 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 869729005188 hypothetical protein; Provisional; Region: PRK05114 869729005189 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 869729005190 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 869729005191 homotrimer interaction site [polypeptide binding]; other site 869729005192 putative active site [active] 869729005193 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 869729005194 DEAD/DEAH box helicase; Region: DEAD; pfam00270 869729005195 DEAD_2; Region: DEAD_2; pfam06733 869729005196 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 869729005197 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 869729005198 Glycoprotease family; Region: Peptidase_M22; pfam00814 869729005199 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 869729005200 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 869729005201 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 869729005202 acyl-activating enzyme (AAE) consensus motif; other site 869729005203 putative AMP binding site [chemical binding]; other site 869729005204 putative active site [active] 869729005205 putative CoA binding site [chemical binding]; other site 869729005206 ribonuclease D; Provisional; Region: PRK10829 869729005207 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 869729005208 catalytic site [active] 869729005209 putative active site [active] 869729005210 putative substrate binding site [chemical binding]; other site 869729005211 Helicase and RNase D C-terminal; Region: HRDC; smart00341 869729005212 leucine export protein LeuE; Provisional; Region: PRK10958 869729005213 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 869729005214 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 869729005215 hypothetical protein; Provisional; Region: PRK10457 869729005216 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 869729005217 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 869729005218 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 869729005219 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 869729005220 metal binding site [ion binding]; metal-binding site 869729005221 active site 869729005222 I-site; other site 869729005223 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 869729005224 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 869729005225 Domain of unknown function (DUF333); Region: DUF333; pfam03891 869729005226 Uncharacterized conserved protein [Function unknown]; Region: COG3189 869729005227 cyanate transporter; Region: CynX; TIGR00896 869729005228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729005229 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 869729005230 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729005231 Predicted membrane protein [Function unknown]; Region: COG2707 869729005232 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 869729005233 putative deacylase active site [active] 869729005234 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 869729005235 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 869729005236 metal binding site [ion binding]; metal-binding site 869729005237 active site 869729005238 I-site; other site 869729005239 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 869729005240 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 869729005241 metal binding site [ion binding]; metal-binding site 869729005242 active site 869729005243 I-site; other site 869729005244 hypothetical protein; Provisional; Region: PRK05325 869729005245 PrkA family serine protein kinase; Provisional; Region: PRK15455 869729005246 AAA ATPase domain; Region: AAA_16; pfam13191 869729005247 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 869729005248 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 869729005249 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 869729005250 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 869729005251 active site 869729005252 catalytic tetrad [active] 869729005253 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 869729005254 active site 869729005255 phosphate binding residues; other site 869729005256 catalytic residues [active] 869729005257 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 869729005258 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 869729005259 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 869729005260 methionine sulfoxide reductase B; Provisional; Region: PRK00222 869729005261 SelR domain; Region: SelR; pfam01641 869729005262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 869729005263 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 869729005264 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 869729005265 putative NAD(P) binding site [chemical binding]; other site 869729005266 catalytic Zn binding site [ion binding]; other site 869729005267 structural Zn binding site [ion binding]; other site 869729005268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729005269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729005270 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 869729005271 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 869729005272 inhibitor binding site; inhibition site 869729005273 catalytic Zn binding site [ion binding]; other site 869729005274 structural Zn binding site [ion binding]; other site 869729005275 NADP binding site [chemical binding]; other site 869729005276 tetramer interface [polypeptide binding]; other site 869729005277 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 869729005278 intersubunit interface [polypeptide binding]; other site 869729005279 active site 869729005280 zinc binding site [ion binding]; other site 869729005281 Na+ binding site [ion binding]; other site 869729005282 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 869729005283 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 869729005284 substrate binding site [chemical binding]; other site 869729005285 ATP binding site [chemical binding]; other site 869729005286 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 869729005287 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 869729005288 active site 869729005289 catalytic tetrad [active] 869729005290 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 869729005291 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 869729005292 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869729005293 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 869729005294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729005295 putative substrate translocation pore; other site 869729005296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729005297 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 869729005298 Isochorismatase family; Region: Isochorismatase; pfam00857 869729005299 catalytic triad [active] 869729005300 metal binding site [ion binding]; metal-binding site 869729005301 conserved cis-peptide bond; other site 869729005302 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 869729005303 active site 869729005304 homodimer interface [polypeptide binding]; other site 869729005305 protease 4; Provisional; Region: PRK10949 869729005306 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 869729005307 tandem repeat interface [polypeptide binding]; other site 869729005308 oligomer interface [polypeptide binding]; other site 869729005309 active site residues [active] 869729005310 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 869729005311 tandem repeat interface [polypeptide binding]; other site 869729005312 oligomer interface [polypeptide binding]; other site 869729005313 active site residues [active] 869729005314 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 869729005315 putative FMN binding site [chemical binding]; other site 869729005316 selenophosphate synthetase; Provisional; Region: PRK00943 869729005317 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 869729005318 dimerization interface [polypeptide binding]; other site 869729005319 putative ATP binding site [chemical binding]; other site 869729005320 DNA topoisomerase III; Provisional; Region: PRK07726 869729005321 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 869729005322 active site 869729005323 putative interdomain interaction site [polypeptide binding]; other site 869729005324 putative metal-binding site [ion binding]; other site 869729005325 putative nucleotide binding site [chemical binding]; other site 869729005326 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 869729005327 domain I; other site 869729005328 DNA binding groove [nucleotide binding] 869729005329 phosphate binding site [ion binding]; other site 869729005330 domain II; other site 869729005331 domain III; other site 869729005332 nucleotide binding site [chemical binding]; other site 869729005333 catalytic site [active] 869729005334 domain IV; other site 869729005335 glutamate dehydrogenase; Provisional; Region: PRK09414 869729005336 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 869729005337 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 869729005338 NAD(P) binding site [chemical binding]; other site 869729005339 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 869729005340 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 869729005341 active site 869729005342 8-oxo-dGMP binding site [chemical binding]; other site 869729005343 nudix motif; other site 869729005344 metal binding site [ion binding]; metal-binding site 869729005345 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 869729005346 Rhodanese Homology Domain; Region: RHOD; smart00450 869729005347 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 869729005348 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 869729005349 active site residue [active] 869729005350 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 869729005351 active site residue [active] 869729005352 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 869729005353 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869729005354 Walker A/P-loop; other site 869729005355 ATP binding site [chemical binding]; other site 869729005356 Q-loop/lid; other site 869729005357 ABC transporter signature motif; other site 869729005358 Walker B; other site 869729005359 D-loop; other site 869729005360 H-loop/switch region; other site 869729005361 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 869729005362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729005363 dimer interface [polypeptide binding]; other site 869729005364 conserved gate region; other site 869729005365 putative PBP binding loops; other site 869729005366 ABC-ATPase subunit interface; other site 869729005367 potential frameshift: common BLAST hit: gi|218689695|ref|YP_002397907.1| putative ABC transporter solute-binding protein 869729005368 Uncharacterized conserved protein [Function unknown]; Region: COG2128 869729005369 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 869729005370 Uncharacterized conserved protein [Function unknown]; Region: COG0398 869729005371 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 869729005372 Uncharacterized conserved protein [Function unknown]; Region: COG0398 869729005373 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 869729005374 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 869729005375 putative catalytic site [active] 869729005376 putative phosphate binding site [ion binding]; other site 869729005377 active site 869729005378 metal binding site A [ion binding]; metal-binding site 869729005379 DNA binding site [nucleotide binding] 869729005380 putative AP binding site [nucleotide binding]; other site 869729005381 putative metal binding site B [ion binding]; other site 869729005382 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 869729005383 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 869729005384 inhibitor-cofactor binding pocket; inhibition site 869729005385 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729005386 catalytic residue [active] 869729005387 arginine succinyltransferase; Provisional; Region: PRK10456 869729005388 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 869729005389 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 869729005390 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 869729005391 NAD(P) binding site [chemical binding]; other site 869729005392 catalytic residues [active] 869729005393 succinylarginine dihydrolase; Provisional; Region: PRK13281 869729005394 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 869729005395 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 869729005396 putative active site [active] 869729005397 Zn binding site [ion binding]; other site 869729005398 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 869729005399 dimer interface [polypeptide binding]; other site 869729005400 hypothetical protein; Provisional; Region: PRK11396 869729005401 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 869729005402 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 869729005403 GIY-YIG motif/motif A; other site 869729005404 active site 869729005405 catalytic site [active] 869729005406 putative DNA binding site [nucleotide binding]; other site 869729005407 metal binding site [ion binding]; metal-binding site 869729005408 NAD+ synthetase; Region: nadE; TIGR00552 869729005409 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 869729005410 homodimer interface [polypeptide binding]; other site 869729005411 NAD binding pocket [chemical binding]; other site 869729005412 ATP binding pocket [chemical binding]; other site 869729005413 Mg binding site [ion binding]; other site 869729005414 active-site loop [active] 869729005415 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 869729005416 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 869729005417 active site 869729005418 P-loop; other site 869729005419 phosphorylation site [posttranslational modification] 869729005420 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 869729005421 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 869729005422 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 869729005423 methionine cluster; other site 869729005424 active site 869729005425 phosphorylation site [posttranslational modification] 869729005426 metal binding site [ion binding]; metal-binding site 869729005427 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 869729005428 Cupin domain; Region: Cupin_2; pfam07883 869729005429 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729005430 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 869729005431 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 869729005432 NAD binding site [chemical binding]; other site 869729005433 sugar binding site [chemical binding]; other site 869729005434 divalent metal binding site [ion binding]; other site 869729005435 tetramer (dimer of dimers) interface [polypeptide binding]; other site 869729005436 dimer interface [polypeptide binding]; other site 869729005437 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 869729005438 putative active site [active] 869729005439 YdjC motif; other site 869729005440 Mg binding site [ion binding]; other site 869729005441 putative homodimer interface [polypeptide binding]; other site 869729005442 hydroperoxidase II; Provisional; Region: katE; PRK11249 869729005443 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 869729005444 tetramer interface [polypeptide binding]; other site 869729005445 heme binding pocket [chemical binding]; other site 869729005446 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 869729005447 domain interactions; other site 869729005448 cell division modulator; Provisional; Region: PRK10113 869729005449 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 869729005450 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 869729005451 inner membrane protein; Provisional; Region: PRK11648 869729005452 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 869729005453 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 869729005454 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869729005455 motif II; other site 869729005456 YniB-like protein; Region: YniB; pfam14002 869729005457 Phosphotransferase enzyme family; Region: APH; pfam01636 869729005458 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 869729005459 active site 869729005460 ATP binding site [chemical binding]; other site 869729005461 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 869729005462 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 869729005463 6-phosphofructokinase 2; Provisional; Region: PRK10294 869729005464 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 869729005465 putative substrate binding site [chemical binding]; other site 869729005466 putative ATP binding site [chemical binding]; other site 869729005467 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 869729005468 potential frameshift: common BLAST hit: gi|254793337|ref|YP_003078174.1| non-LEE-encoded type III secreted effector 869729005469 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 869729005470 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 869729005471 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 869729005472 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 869729005473 active site 869729005474 dimer interface [polypeptide binding]; other site 869729005475 motif 1; other site 869729005476 motif 2; other site 869729005477 motif 3; other site 869729005478 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 869729005479 anticodon binding site; other site 869729005480 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 869729005481 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 869729005482 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 869729005483 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 869729005484 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 869729005485 23S rRNA binding site [nucleotide binding]; other site 869729005486 L21 binding site [polypeptide binding]; other site 869729005487 L13 binding site [polypeptide binding]; other site 869729005488 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 869729005489 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 869729005490 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 869729005491 dimer interface [polypeptide binding]; other site 869729005492 motif 1; other site 869729005493 active site 869729005494 motif 2; other site 869729005495 motif 3; other site 869729005496 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 869729005497 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 869729005498 putative tRNA-binding site [nucleotide binding]; other site 869729005499 B3/4 domain; Region: B3_4; pfam03483 869729005500 tRNA synthetase B5 domain; Region: B5; smart00874 869729005501 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 869729005502 dimer interface [polypeptide binding]; other site 869729005503 motif 1; other site 869729005504 motif 3; other site 869729005505 motif 2; other site 869729005506 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 869729005507 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 869729005508 IHF dimer interface [polypeptide binding]; other site 869729005509 IHF - DNA interface [nucleotide binding]; other site 869729005510 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 869729005511 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869729005512 ABC-ATPase subunit interface; other site 869729005513 dimer interface [polypeptide binding]; other site 869729005514 putative PBP binding regions; other site 869729005515 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 869729005516 catalytic residues [active] 869729005517 dimer interface [polypeptide binding]; other site 869729005518 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 869729005519 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 869729005520 Walker A/P-loop; other site 869729005521 ATP binding site [chemical binding]; other site 869729005522 Q-loop/lid; other site 869729005523 ABC transporter signature motif; other site 869729005524 Walker B; other site 869729005525 D-loop; other site 869729005526 H-loop/switch region; other site 869729005527 NlpC/P60 family; Region: NLPC_P60; pfam00877 869729005528 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 869729005529 Uncharacterized conserved protein [Function unknown]; Region: COG0397 869729005530 hypothetical protein; Validated; Region: PRK00029 869729005531 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 869729005532 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 869729005533 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 869729005534 PEP synthetase regulatory protein; Provisional; Region: PRK05339 869729005535 phosphoenolpyruvate synthase; Validated; Region: PRK06464 869729005536 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 869729005537 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 869729005538 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 869729005539 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 869729005540 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 869729005541 acyl-activating enzyme (AAE) consensus motif; other site 869729005542 putative AMP binding site [chemical binding]; other site 869729005543 putative active site [active] 869729005544 putative CoA binding site [chemical binding]; other site 869729005545 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 869729005546 oxidoreductase; Provisional; Region: PRK10015 869729005547 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 869729005548 Electron transfer flavoprotein domain; Region: ETF; smart00893 869729005549 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 869729005550 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 869729005551 Ligand binding site [chemical binding]; other site 869729005552 Electron transfer flavoprotein domain; Region: ETF; pfam01012 869729005553 Cupin domain; Region: Cupin_2; pfam07883 869729005554 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 869729005555 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 869729005556 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729005557 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 869729005558 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 869729005559 active site 869729005560 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 869729005561 Coenzyme A transferase; Region: CoA_trans; smart00882 869729005562 Coenzyme A transferase; Region: CoA_trans; cl17247 869729005563 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 869729005564 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 869729005565 active site 869729005566 catalytic residue [active] 869729005567 dimer interface [polypeptide binding]; other site 869729005568 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 869729005569 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 869729005570 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 869729005571 shikimate binding site; other site 869729005572 NAD(P) binding site [chemical binding]; other site 869729005573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729005574 putative substrate translocation pore; other site 869729005575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729005576 Major Facilitator Superfamily; Region: MFS_1; pfam07690 869729005577 putative substrate translocation pore; other site 869729005578 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 869729005579 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 869729005580 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 869729005581 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 869729005582 FAD binding domain; Region: FAD_binding_4; pfam01565 869729005583 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 869729005584 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 869729005585 CoenzymeA binding site [chemical binding]; other site 869729005586 subunit interaction site [polypeptide binding]; other site 869729005587 PHB binding site; other site 869729005588 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 869729005589 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 869729005590 putative ABC transporter; Region: ycf24; CHL00085 869729005591 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 869729005592 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 869729005593 Walker A/P-loop; other site 869729005594 ATP binding site [chemical binding]; other site 869729005595 Q-loop/lid; other site 869729005596 ABC transporter signature motif; other site 869729005597 Walker B; other site 869729005598 D-loop; other site 869729005599 H-loop/switch region; other site 869729005600 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 869729005601 FeS assembly protein SufD; Region: sufD; TIGR01981 869729005602 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 869729005603 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 869729005604 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869729005605 catalytic residue [active] 869729005606 cysteine desufuration protein SufE; Provisional; Region: PRK09296 869729005607 L,D-transpeptidase; Provisional; Region: PRK10190 869729005608 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869729005609 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 869729005610 murein lipoprotein; Provisional; Region: PRK15396 869729005611 pyruvate kinase; Provisional; Region: PRK09206 869729005612 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 869729005613 domain interfaces; other site 869729005614 active site 869729005615 hypothetical protein; Provisional; Region: PRK10292 869729005616 hypothetical protein; Provisional; Region: PRK09898 869729005617 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 869729005618 putative oxidoreductase; Provisional; Region: PRK09849 869729005619 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 869729005620 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 869729005621 hypothetical protein; Provisional; Region: PRK09947 869729005622 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 869729005623 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 869729005624 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 869729005625 hypothetical protein; Provisional; Region: PRK09946 869729005626 hypothetical protein; Provisional; Region: PRK09897 869729005627 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 869729005628 putative monooxygenase; Provisional; Region: PRK11118 869729005629 hypothetical protein; Provisional; Region: PRK09945 869729005630 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 869729005631 multidrug efflux protein; Reviewed; Region: PRK01766 869729005632 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 869729005633 cation binding site [ion binding]; other site 869729005634 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 869729005635 Lumazine binding domain; Region: Lum_binding; pfam00677 869729005636 Lumazine binding domain; Region: Lum_binding; pfam00677 869729005637 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 869729005638 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 869729005639 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729005640 S-adenosylmethionine binding site [chemical binding]; other site 869729005641 putative transporter; Provisional; Region: PRK11043 869729005642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729005643 putative substrate translocation pore; other site 869729005644 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 869729005645 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729005646 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 869729005647 dimerization interface [polypeptide binding]; other site 869729005648 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 869729005649 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869729005650 DNA binding site [nucleotide binding] 869729005651 domain linker motif; other site 869729005652 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 869729005653 dimerization interface [polypeptide binding]; other site 869729005654 ligand binding site [chemical binding]; other site 869729005655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729005656 Major Facilitator Superfamily; Region: MFS_1; pfam07690 869729005657 putative substrate translocation pore; other site 869729005658 superoxide dismutase; Provisional; Region: PRK10543 869729005659 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 869729005660 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 869729005661 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 869729005662 NlpC/P60 family; Region: NLPC_P60; pfam00877 869729005663 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 869729005664 putative GSH binding site [chemical binding]; other site 869729005665 catalytic residues [active] 869729005666 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 869729005667 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 869729005668 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 869729005669 dimer interface [polypeptide binding]; other site 869729005670 catalytic site [active] 869729005671 putative active site [active] 869729005672 putative substrate binding site [chemical binding]; other site 869729005673 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 869729005674 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 869729005675 dimer interface [polypeptide binding]; other site 869729005676 active site 869729005677 metal binding site [ion binding]; metal-binding site 869729005678 glutathione binding site [chemical binding]; other site 869729005679 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 869729005680 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 869729005681 FMN binding site [chemical binding]; other site 869729005682 active site 869729005683 substrate binding site [chemical binding]; other site 869729005684 catalytic residue [active] 869729005685 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869729005686 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869729005687 Predicted Fe-S protein [General function prediction only]; Region: COG3313 869729005688 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 869729005689 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 869729005690 active site 869729005691 catalytic tetrad [active] 869729005692 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 869729005693 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 869729005694 E-class dimer interface [polypeptide binding]; other site 869729005695 P-class dimer interface [polypeptide binding]; other site 869729005696 active site 869729005697 Cu2+ binding site [ion binding]; other site 869729005698 Zn2+ binding site [ion binding]; other site 869729005699 Fusaric acid resistance protein family; Region: FUSC; pfam04632 869729005700 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 869729005701 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 869729005702 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 869729005703 HlyD family secretion protein; Region: HlyD_3; pfam13437 869729005704 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 869729005705 transcriptional regulator SlyA; Provisional; Region: PRK03573 869729005706 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 869729005707 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 869729005708 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 869729005709 lysozyme inhibitor; Provisional; Region: PRK11372 869729005710 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 869729005711 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 869729005712 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 869729005713 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 869729005714 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 869729005715 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 869729005716 active site 869729005717 HIGH motif; other site 869729005718 dimer interface [polypeptide binding]; other site 869729005719 KMSKS motif; other site 869729005720 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869729005721 RNA binding surface [nucleotide binding]; other site 869729005722 pyridoxamine kinase; Validated; Region: PRK05756 869729005723 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 869729005724 dimer interface [polypeptide binding]; other site 869729005725 pyridoxal binding site [chemical binding]; other site 869729005726 ATP binding site [chemical binding]; other site 869729005727 glutathionine S-transferase; Provisional; Region: PRK10542 869729005728 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 869729005729 C-terminal domain interface [polypeptide binding]; other site 869729005730 GSH binding site (G-site) [chemical binding]; other site 869729005731 dimer interface [polypeptide binding]; other site 869729005732 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 869729005733 N-terminal domain interface [polypeptide binding]; other site 869729005734 dimer interface [polypeptide binding]; other site 869729005735 substrate binding pocket (H-site) [chemical binding]; other site 869729005736 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 869729005737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729005738 putative substrate translocation pore; other site 869729005739 POT family; Region: PTR2; pfam00854 869729005740 endonuclease III; Provisional; Region: PRK10702 869729005741 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 869729005742 minor groove reading motif; other site 869729005743 helix-hairpin-helix signature motif; other site 869729005744 substrate binding pocket [chemical binding]; other site 869729005745 active site 869729005746 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 869729005747 electron transport complex RsxE subunit; Provisional; Region: PRK12405 869729005748 electron transport complex protein RnfG; Validated; Region: PRK01908 869729005749 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 869729005750 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 869729005751 SLBB domain; Region: SLBB; pfam10531 869729005752 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 869729005753 electron transport complex protein RnfB; Provisional; Region: PRK05113 869729005754 Putative Fe-S cluster; Region: FeS; pfam04060 869729005755 4Fe-4S binding domain; Region: Fer4; pfam00037 869729005756 electron transport complex protein RsxA; Provisional; Region: PRK05151 869729005757 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 869729005758 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 869729005759 putative oxidoreductase; Provisional; Region: PRK11579 869729005760 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 869729005761 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 869729005762 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 869729005763 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 869729005764 active site 869729005765 purine riboside binding site [chemical binding]; other site 869729005766 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 869729005767 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869729005768 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729005769 homodimer interface [polypeptide binding]; other site 869729005770 catalytic residue [active] 869729005771 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 869729005772 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 869729005773 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869729005774 active site turn [active] 869729005775 phosphorylation site [posttranslational modification] 869729005776 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 869729005777 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869729005778 DNA binding site [nucleotide binding] 869729005779 domain linker motif; other site 869729005780 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 869729005781 putative dimerization interface [polypeptide binding]; other site 869729005782 putative ligand binding site [chemical binding]; other site 869729005783 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 869729005784 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 869729005785 NAD binding site [chemical binding]; other site 869729005786 substrate binding site [chemical binding]; other site 869729005787 homotetramer interface [polypeptide binding]; other site 869729005788 homodimer interface [polypeptide binding]; other site 869729005789 active site 869729005790 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869729005791 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869729005792 beta-D-glucuronidase; Provisional; Region: PRK10150 869729005793 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 869729005794 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 869729005795 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 869729005796 glucuronide transporter; Provisional; Region: PRK09848 869729005797 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 869729005798 putative outer membrane porin protein; Provisional; Region: PRK11379 869729005799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 869729005800 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 869729005801 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 869729005802 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 869729005803 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 869729005804 fumarate hydratase; Provisional; Region: PRK15389 869729005805 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 869729005806 Fumarase C-terminus; Region: Fumerase_C; pfam05683 869729005807 fumarate hydratase; Reviewed; Region: fumC; PRK00485 869729005808 Class II fumarases; Region: Fumarase_classII; cd01362 869729005809 active site 869729005810 tetramer interface [polypeptide binding]; other site 869729005811 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 869729005812 potential frameshift: common BLAST hit: gi|218689555|ref|YP_002397767.1| sensor protein RstB 869729005813 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 869729005814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729005815 active site 869729005816 phosphorylation site [posttranslational modification] 869729005817 intermolecular recognition site; other site 869729005818 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869729005819 DNA binding site [nucleotide binding] 869729005820 GlpM protein; Region: GlpM; pfam06942 869729005821 dihydromonapterin reductase; Provisional; Region: PRK06483 869729005822 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 869729005823 NADP binding site [chemical binding]; other site 869729005824 substrate binding pocket [chemical binding]; other site 869729005825 active site 869729005826 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 869729005827 Spore germination protein; Region: Spore_permease; cl17796 869729005828 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 869729005829 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 869729005830 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 869729005831 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 869729005832 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 869729005833 ligand binding site [chemical binding]; other site 869729005834 homodimer interface [polypeptide binding]; other site 869729005835 NAD(P) binding site [chemical binding]; other site 869729005836 trimer interface B [polypeptide binding]; other site 869729005837 trimer interface A [polypeptide binding]; other site 869729005838 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 869729005839 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 869729005840 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 869729005841 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 869729005842 Domain of unknown function DUF20; Region: UPF0118; pfam01594 869729005843 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 869729005844 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 869729005845 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 869729005846 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 869729005847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729005848 putative substrate translocation pore; other site 869729005849 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 869729005850 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729005851 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 869729005852 dimerization interface [polypeptide binding]; other site 869729005853 substrate binding pocket [chemical binding]; other site 869729005854 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 869729005855 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 869729005856 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 869729005857 nucleotide binding site [chemical binding]; other site 869729005858 putative dithiobiotin synthetase; Provisional; Region: PRK12374 869729005859 AAA domain; Region: AAA_26; pfam13500 869729005860 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 869729005861 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 869729005862 Cl- selectivity filter; other site 869729005863 Cl- binding residues [ion binding]; other site 869729005864 pore gating glutamate residue; other site 869729005865 dimer interface [polypeptide binding]; other site 869729005866 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 869729005867 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 869729005868 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 869729005869 4Fe-4S binding domain; Region: Fer4; cl02805 869729005870 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 869729005871 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 869729005872 putative [Fe4-S4] binding site [ion binding]; other site 869729005873 putative molybdopterin cofactor binding site [chemical binding]; other site 869729005874 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 869729005875 putative molybdopterin cofactor binding site; other site 869729005876 potential frameshift: common BLAST hit: gi|218558457|ref|YP_002391370.1| oxidoreductase subunit 869729005877 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 869729005878 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 869729005879 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 869729005880 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869729005881 Coenzyme A binding pocket [chemical binding]; other site 869729005882 hypothetical protein; Provisional; Region: PRK13659 869729005883 hypothetical protein; Provisional; Region: PRK02237 869729005884 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 869729005885 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 869729005886 putative active site pocket [active] 869729005887 putative metal binding site [ion binding]; other site 869729005888 putative oxidoreductase; Provisional; Region: PRK10083 869729005889 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 869729005890 putative NAD(P) binding site [chemical binding]; other site 869729005891 catalytic Zn binding site [ion binding]; other site 869729005892 structural Zn binding site [ion binding]; other site 869729005893 metabolite-proton symporter; Region: 2A0106; TIGR00883 869729005894 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 869729005895 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 869729005896 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 869729005897 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 869729005898 Transcriptional regulators [Transcription]; Region: GntR; COG1802 869729005899 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869729005900 DNA-binding site [nucleotide binding]; DNA binding site 869729005901 FCD domain; Region: FCD; pfam07729 869729005902 malonic semialdehyde reductase; Provisional; Region: PRK10538 869729005903 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 869729005904 putative NAD(P) binding site [chemical binding]; other site 869729005905 homodimer interface [polypeptide binding]; other site 869729005906 homotetramer interface [polypeptide binding]; other site 869729005907 active site 869729005908 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 869729005909 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 869729005910 active site 869729005911 Zn binding site [ion binding]; other site 869729005912 diguanylate cyclase; Provisional; Region: PRK09894 869729005913 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 869729005914 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 869729005915 metal binding site [ion binding]; metal-binding site 869729005916 active site 869729005917 I-site; other site 869729005918 putative transporter; Provisional; Region: PRK10054 869729005919 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729005920 putative substrate translocation pore; other site 869729005921 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 869729005922 EamA-like transporter family; Region: EamA; pfam00892 869729005923 EamA-like transporter family; Region: EamA; pfam00892 869729005924 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 869729005925 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869729005926 DNA-binding site [nucleotide binding]; DNA binding site 869729005927 UTRA domain; Region: UTRA; pfam07702 869729005928 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 869729005929 active site 869729005930 P-loop; other site 869729005931 phosphorylation site [posttranslational modification] 869729005932 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 869729005933 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 869729005934 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 869729005935 active site 869729005936 methionine cluster; other site 869729005937 phosphorylation site [posttranslational modification] 869729005938 metal binding site [ion binding]; metal-binding site 869729005939 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 869729005940 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 869729005941 trimer interface; other site 869729005942 sugar binding site [chemical binding]; other site 869729005943 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 869729005944 beta-galactosidase; Region: BGL; TIGR03356 869729005945 hypothetical protein; Provisional; Region: PRK10106 869729005946 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 869729005947 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729005948 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729005949 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 869729005950 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 869729005951 inner membrane protein; Provisional; Region: PRK10995 869729005952 putative arabinose transporter; Provisional; Region: PRK03545 869729005953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729005954 putative substrate translocation pore; other site 869729005955 Transcriptional regulator [Transcription]; Region: LysR; COG0583 869729005956 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729005957 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 869729005958 putative dimerization interface [polypeptide binding]; other site 869729005959 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 869729005960 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 869729005961 NAD(P) binding site [chemical binding]; other site 869729005962 catalytic residues [active] 869729005963 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 869729005964 glutaminase; Provisional; Region: PRK00971 869729005965 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 869729005966 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 869729005967 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 869729005968 metal binding site [ion binding]; metal-binding site 869729005969 active site 869729005970 I-site; other site 869729005971 altronate oxidoreductase; Provisional; Region: PRK03643 869729005972 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 869729005973 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 869729005974 Predicted membrane protein [Function unknown]; Region: COG3781 869729005975 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 869729005976 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729005977 S-adenosylmethionine binding site [chemical binding]; other site 869729005978 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869729005979 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869729005980 non-specific DNA binding site [nucleotide binding]; other site 869729005981 salt bridge; other site 869729005982 sequence-specific DNA binding site [nucleotide binding]; other site 869729005983 HipA N-terminal domain; Region: Couple_hipA; pfam13657 869729005984 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 869729005985 HipA-like N-terminal domain; Region: HipA_N; pfam07805 869729005986 HipA-like C-terminal domain; Region: HipA_C; pfam07804 869729005987 Phage replication protein CRI; Region: Phage_CRI; pfam05144 869729005988 phage/plasmid replication protein, gene II/X family; Region: rep_II_X; TIGR01629 869729005989 Phage X family; Region: Phage_X; pfam05155 869729005990 major coat protein; Region: VIII; PHA00025 869729005991 Phage Coat Protein A; Region: Phage_Coat_A; pfam05357 869729005992 attachment protein; Region: III; PHA00370 869729005993 minor coat protein; Region: VI; PHA00094 869729005994 Zonular occludens toxin (Zot); Region: Zot; cl17485 869729005995 phage assembly protein; Region: IV; PHA00019 869729005996 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 869729005997 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 869729005998 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 869729005999 NADH(P)-binding; Region: NAD_binding_10; pfam13460 869729006000 NAD(P) binding site [chemical binding]; other site 869729006001 putative active site [active] 869729006002 Fimbrial protein; Region: Fimbrial; cl01416 869729006003 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 869729006004 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 869729006005 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 869729006006 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 869729006007 PapC N-terminal domain; Region: PapC_N; pfam13954 869729006008 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 869729006009 PapC C-terminal domain; Region: PapC_C; pfam13953 869729006010 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 869729006011 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 869729006012 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 869729006013 mannosyl binding site [chemical binding]; other site 869729006014 putative oxidoreductase; Provisional; Region: PRK09939 869729006015 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 869729006016 putative molybdopterin cofactor binding site [chemical binding]; other site 869729006017 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 869729006018 putative molybdopterin cofactor binding site; other site 869729006019 transcriptional regulator YdeO; Provisional; Region: PRK09940 869729006020 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729006021 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 869729006022 Sulfatase; Region: Sulfatase; pfam00884 869729006023 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 869729006024 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869729006025 FeS/SAM binding site; other site 869729006026 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 869729006027 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 869729006028 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 869729006029 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 869729006030 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 869729006031 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 869729006032 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 869729006033 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 869729006034 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 869729006035 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 869729006036 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 869729006037 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 869729006038 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729006039 catalytic residue [active] 869729006040 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 869729006041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 869729006042 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 869729006043 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 869729006044 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 869729006045 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 869729006046 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869729006047 putative active site [active] 869729006048 heme pocket [chemical binding]; other site 869729006049 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869729006050 putative active site [active] 869729006051 heme pocket [chemical binding]; other site 869729006052 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 869729006053 metal binding site [ion binding]; metal-binding site 869729006054 active site 869729006055 I-site; other site 869729006056 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 869729006057 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 869729006058 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 869729006059 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 869729006060 malate dehydrogenase; Provisional; Region: PRK13529 869729006061 Malic enzyme, N-terminal domain; Region: malic; pfam00390 869729006062 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 869729006063 NAD(P) binding site [chemical binding]; other site 869729006064 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 869729006065 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 869729006066 NAD binding site [chemical binding]; other site 869729006067 substrate binding site [chemical binding]; other site 869729006068 catalytic Zn binding site [ion binding]; other site 869729006069 tetramer interface [polypeptide binding]; other site 869729006070 structural Zn binding site [ion binding]; other site 869729006071 Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015 869729006072 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 869729006073 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869729006074 non-specific DNA binding site [nucleotide binding]; other site 869729006075 salt bridge; other site 869729006076 sequence-specific DNA binding site [nucleotide binding]; other site 869729006077 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 869729006078 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 869729006079 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 869729006080 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 869729006081 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 869729006082 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 869729006083 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 869729006084 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 869729006085 molybdopterin cofactor binding site; other site 869729006086 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 869729006087 aromatic amino acid exporter; Provisional; Region: PRK11689 869729006088 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 869729006089 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 869729006090 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 869729006091 [4Fe-4S] binding site [ion binding]; other site 869729006092 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 869729006093 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 869729006094 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 869729006095 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 869729006096 molybdopterin cofactor binding site; other site 869729006097 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 869729006098 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 869729006099 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 869729006100 hypothetical protein; Provisional; Region: PRK10281 869729006101 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 869729006102 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 869729006103 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 869729006104 Peptidase M35-like domain of uncharacterized proteins; Region: M35_like_1; cd11007 869729006105 putative active site [active] 869729006106 putative Zn binding site [ion binding]; other site 869729006107 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 869729006108 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 869729006109 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 869729006110 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 869729006111 PAAR motif; Region: PAAR_motif; pfam05488 869729006112 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 869729006113 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 869729006114 N-terminal domain interface [polypeptide binding]; other site 869729006115 dimer interface [polypeptide binding]; other site 869729006116 substrate binding pocket (H-site) [chemical binding]; other site 869729006117 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 869729006118 L-asparagine permease; Provisional; Region: PRK15049 869729006119 PQQ-like domain; Region: PQQ_2; pfam13360 869729006120 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 869729006121 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 869729006122 N-terminal plug; other site 869729006123 ligand-binding site [chemical binding]; other site 869729006124 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 869729006125 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 869729006126 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 869729006127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 869729006128 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 869729006129 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 869729006130 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 869729006131 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 869729006132 tetrameric interface [polypeptide binding]; other site 869729006133 NAD binding site [chemical binding]; other site 869729006134 catalytic residues [active] 869729006135 substrate binding site [chemical binding]; other site 869729006136 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 869729006137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729006138 ABC-ATPase subunit interface; other site 869729006139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729006140 dimer interface [polypeptide binding]; other site 869729006141 conserved gate region; other site 869729006142 putative PBP binding loops; other site 869729006143 ABC-ATPase subunit interface; other site 869729006144 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 869729006145 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869729006146 Walker A/P-loop; other site 869729006147 ATP binding site [chemical binding]; other site 869729006148 Q-loop/lid; other site 869729006149 ABC transporter signature motif; other site 869729006150 Walker B; other site 869729006151 D-loop; other site 869729006152 H-loop/switch region; other site 869729006153 TOBE domain; Region: TOBE_2; pfam08402 869729006154 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 869729006155 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 869729006156 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 869729006157 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869729006158 DNA-binding site [nucleotide binding]; DNA binding site 869729006159 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869729006160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729006161 homodimer interface [polypeptide binding]; other site 869729006162 catalytic residue [active] 869729006163 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 869729006164 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 869729006165 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 869729006166 Peptidase family U32; Region: Peptidase_U32; pfam01136 869729006167 Collagenase; Region: DUF3656; pfam12392 869729006168 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869729006169 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869729006170 non-specific DNA binding site [nucleotide binding]; other site 869729006171 salt bridge; other site 869729006172 sequence-specific DNA binding site [nucleotide binding]; other site 869729006173 Cupin domain; Region: Cupin_2; pfam07883 869729006174 potential frameshift: common BLAST hit: gi|218558365|ref|YP_002391278.1| putative benzoate transporter 869729006175 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 869729006176 tellurite resistance protein TehB; Provisional; Region: PRK11207 869729006177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729006178 S-adenosylmethionine binding site [chemical binding]; other site 869729006179 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 869729006180 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 869729006181 gating phenylalanine in ion channel; other site 869729006182 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 869729006183 putative trimer interface [polypeptide binding]; other site 869729006184 putative CoA binding site [chemical binding]; other site 869729006185 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 869729006186 putative trimer interface [polypeptide binding]; other site 869729006187 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 869729006188 putative CoA binding site [chemical binding]; other site 869729006189 putative trimer interface [polypeptide binding]; other site 869729006190 putative CoA binding site [chemical binding]; other site 869729006191 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 869729006192 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869729006193 Coenzyme A binding pocket [chemical binding]; other site 869729006194 hypothetical protein; Provisional; Region: PRK11415 869729006195 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 869729006196 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 869729006197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 869729006198 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 869729006199 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 869729006200 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729006201 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 869729006202 dimerization interface [polypeptide binding]; other site 869729006203 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 869729006204 dimer interface [polypeptide binding]; other site 869729006205 hypothetical protein; Provisional; Region: PRK10040 869729006206 cytochrome b561; Provisional; Region: PRK11513 869729006207 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 869729006208 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 869729006209 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 869729006210 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 869729006211 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 869729006212 NAD binding site [chemical binding]; other site 869729006213 catalytic residues [active] 869729006214 substrate binding site [chemical binding]; other site 869729006215 Uncharacterized conserved protein [Function unknown]; Region: COG1434 869729006216 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 869729006217 putative active site [active] 869729006218 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 869729006219 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869729006220 ATP binding site [chemical binding]; other site 869729006221 putative Mg++ binding site [ion binding]; other site 869729006222 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869729006223 nucleotide binding region [chemical binding]; other site 869729006224 ATP-binding site [chemical binding]; other site 869729006225 Helicase associated domain (HA2); Region: HA2; pfam04408 869729006226 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 869729006227 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 869729006228 azoreductase; Reviewed; Region: PRK00170 869729006229 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 869729006230 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 869729006231 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 869729006232 active site 869729006233 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 869729006234 active site 869729006235 catalytic residues [active] 869729006236 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 869729006237 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 869729006238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729006239 S-adenosylmethionine binding site [chemical binding]; other site 869729006240 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 869729006241 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 869729006242 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 869729006243 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 869729006244 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 869729006245 active site 869729006246 catalytic tetrad [active] 869729006247 potential frameshift: common BLAST hit: gi|218558341|ref|YP_002391254.1| putative autotransported outer membrane protein involved in cell 869729006248 potential frameshift: common BLAST hit: gi|110641590|ref|YP_669320.1| putative autotransporter/adhesin 869729006249 potential frameshift: common BLAST hit: gi|218558341|ref|YP_002391254.1| putative autotransported outer membrane protein involved in cell 869729006250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 869729006251 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 869729006252 hypothetical protein; Provisional; Region: PRK10695 869729006253 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 869729006254 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 869729006255 putative ligand binding site [chemical binding]; other site 869729006256 putative NAD binding site [chemical binding]; other site 869729006257 catalytic site [active] 869729006258 heat-inducible protein; Provisional; Region: PRK10449 869729006259 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 869729006260 Domain of unknown function (DUF333); Region: DUF333; pfam03891 869729006261 metabolite-proton symporter; Region: 2A0106; TIGR00883 869729006262 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 869729006263 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 869729006264 dimer interface [polypeptide binding]; other site 869729006265 PYR/PP interface [polypeptide binding]; other site 869729006266 TPP binding site [chemical binding]; other site 869729006267 substrate binding site [chemical binding]; other site 869729006268 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 869729006269 Domain of unknown function; Region: EKR; smart00890 869729006270 4Fe-4S binding domain; Region: Fer4_6; pfam12837 869729006271 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 869729006272 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 869729006273 TPP-binding site [chemical binding]; other site 869729006274 dimer interface [polypeptide binding]; other site 869729006275 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 869729006276 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 869729006277 trimer interface [polypeptide binding]; other site 869729006278 eyelet of channel; other site 869729006279 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 869729006280 Ligand Binding Site [chemical binding]; other site 869729006281 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 869729006282 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 869729006283 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 869729006284 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 869729006285 Ligand Binding Site [chemical binding]; other site 869729006286 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 869729006287 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 869729006288 ATP binding site [chemical binding]; other site 869729006289 Mg++ binding site [ion binding]; other site 869729006290 motif III; other site 869729006291 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869729006292 nucleotide binding region [chemical binding]; other site 869729006293 ATP-binding site [chemical binding]; other site 869729006294 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 869729006295 putative RNA binding site [nucleotide binding]; other site 869729006296 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 869729006297 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 869729006298 Cl binding site [ion binding]; other site 869729006299 oligomer interface [polypeptide binding]; other site 869729006300 PAS domain S-box; Region: sensory_box; TIGR00229 869729006301 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869729006302 putative active site [active] 869729006303 heme pocket [chemical binding]; other site 869729006304 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 869729006305 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 869729006306 metal binding site [ion binding]; metal-binding site 869729006307 active site 869729006308 I-site; other site 869729006309 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 869729006310 Smr domain; Region: Smr; pfam01713 869729006311 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 869729006312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729006313 putative substrate translocation pore; other site 869729006314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729006315 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 869729006316 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 869729006317 HlyD family secretion protein; Region: HlyD_3; pfam13437 869729006318 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 869729006319 Helix-turn-helix domain; Region: HTH_18; pfam12833 869729006320 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 869729006321 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 869729006322 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 869729006323 DNA binding site [nucleotide binding] 869729006324 active site 869729006325 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 869729006326 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 869729006327 ligand binding site [chemical binding]; other site 869729006328 flexible hinge region; other site 869729006329 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 869729006330 putative switch regulator; other site 869729006331 non-specific DNA interactions [nucleotide binding]; other site 869729006332 DNA binding site [nucleotide binding] 869729006333 sequence specific DNA binding site [nucleotide binding]; other site 869729006334 putative cAMP binding site [chemical binding]; other site 869729006335 universal stress protein UspE; Provisional; Region: PRK11175 869729006336 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 869729006337 Ligand Binding Site [chemical binding]; other site 869729006338 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 869729006339 Ligand Binding Site [chemical binding]; other site 869729006340 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 869729006341 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 869729006342 Mechanosensitive ion channel; Region: MS_channel; pfam00924 869729006343 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 869729006344 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 869729006345 peptide binding site [polypeptide binding]; other site 869729006346 Transcriptional regulator [Transcription]; Region: LysR; COG0583 869729006347 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729006348 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 869729006349 putative effector binding pocket; other site 869729006350 putative dimerization interface [polypeptide binding]; other site 869729006351 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 869729006352 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 869729006353 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 869729006354 NADH(P)-binding; Region: NAD_binding_10; pfam13460 869729006355 putative NAD(P) binding site [chemical binding]; other site 869729006356 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 869729006357 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 869729006358 putative active site [active] 869729006359 Zn binding site [ion binding]; other site 869729006360 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 869729006361 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 869729006362 active site 869729006363 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 869729006364 dimer interface [polypeptide binding]; other site 869729006365 catalytic triad [active] 869729006366 peroxidatic and resolving cysteines [active] 869729006367 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 869729006368 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 869729006369 putative aromatic amino acid binding site; other site 869729006370 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729006371 Walker A motif; other site 869729006372 ATP binding site [chemical binding]; other site 869729006373 Walker B motif; other site 869729006374 arginine finger; other site 869729006375 hypothetical protein; Provisional; Region: PRK05415 869729006376 TIGR01620 family protein; Region: hyp_HI0043 869729006377 Predicted ATPase [General function prediction only]; Region: COG3106 869729006378 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869729006379 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869729006380 DNA binding site [nucleotide binding] 869729006381 domain linker motif; other site 869729006382 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 869729006383 putative dimerization interface [polypeptide binding]; other site 869729006384 putative ligand binding site [chemical binding]; other site 869729006385 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 869729006386 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 869729006387 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 869729006388 Walker A/P-loop; other site 869729006389 ATP binding site [chemical binding]; other site 869729006390 Q-loop/lid; other site 869729006391 ABC transporter signature motif; other site 869729006392 Walker B; other site 869729006393 D-loop; other site 869729006394 H-loop/switch region; other site 869729006395 TOBE domain; Region: TOBE_2; pfam08402 869729006396 beta-phosphoglucomutase; Region: bPGM; TIGR01990 869729006397 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869729006398 motif II; other site 869729006399 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 869729006400 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 869729006401 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 869729006402 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 869729006403 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 869729006404 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 869729006405 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 869729006406 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 869729006407 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 869729006408 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 869729006409 putative NAD(P) binding site [chemical binding]; other site 869729006410 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869729006411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729006412 dimer interface [polypeptide binding]; other site 869729006413 conserved gate region; other site 869729006414 putative PBP binding loops; other site 869729006415 ABC-ATPase subunit interface; other site 869729006416 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 869729006417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729006418 dimer interface [polypeptide binding]; other site 869729006419 conserved gate region; other site 869729006420 putative PBP binding loops; other site 869729006421 ABC-ATPase subunit interface; other site 869729006422 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869729006423 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869729006424 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 869729006425 sucrose phosphorylase; Provisional; Region: PRK13840 869729006426 active site 869729006427 homodimer interface [polypeptide binding]; other site 869729006428 catalytic site [active] 869729006429 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 869729006430 active site residue [active] 869729006431 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 869729006432 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 869729006433 phage shock protein C; Region: phageshock_pspC; TIGR02978 869729006434 phage shock protein B; Provisional; Region: pspB; PRK09458 869729006435 phage shock protein PspA; Provisional; Region: PRK10698 869729006436 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 869729006437 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729006438 Walker A motif; other site 869729006439 ATP binding site [chemical binding]; other site 869729006440 Walker B motif; other site 869729006441 arginine finger; other site 869729006442 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 869729006443 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 869729006444 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 869729006445 peptide binding site [polypeptide binding]; other site 869729006446 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 869729006447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729006448 dimer interface [polypeptide binding]; other site 869729006449 conserved gate region; other site 869729006450 putative PBP binding loops; other site 869729006451 ABC-ATPase subunit interface; other site 869729006452 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 869729006453 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 869729006454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729006455 dimer interface [polypeptide binding]; other site 869729006456 conserved gate region; other site 869729006457 putative PBP binding loops; other site 869729006458 ABC-ATPase subunit interface; other site 869729006459 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 869729006460 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869729006461 Walker A/P-loop; other site 869729006462 ATP binding site [chemical binding]; other site 869729006463 Q-loop/lid; other site 869729006464 ABC transporter signature motif; other site 869729006465 Walker B; other site 869729006466 D-loop; other site 869729006467 H-loop/switch region; other site 869729006468 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 869729006469 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 869729006470 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869729006471 Walker A/P-loop; other site 869729006472 ATP binding site [chemical binding]; other site 869729006473 Q-loop/lid; other site 869729006474 ABC transporter signature motif; other site 869729006475 Walker B; other site 869729006476 D-loop; other site 869729006477 H-loop/switch region; other site 869729006478 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 869729006479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729006480 putative substrate translocation pore; other site 869729006481 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 869729006482 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 869729006483 Protein export membrane protein; Region: SecD_SecF; cl14618 869729006484 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 869729006485 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 869729006486 HlyD family secretion protein; Region: HlyD_3; pfam13437 869729006487 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869729006488 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869729006489 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 869729006490 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 869729006491 NAD binding site [chemical binding]; other site 869729006492 homotetramer interface [polypeptide binding]; other site 869729006493 homodimer interface [polypeptide binding]; other site 869729006494 substrate binding site [chemical binding]; other site 869729006495 active site 869729006496 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 869729006497 Uncharacterized conserved protein [Function unknown]; Region: COG2128 869729006498 exoribonuclease II; Provisional; Region: PRK05054 869729006499 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 869729006500 RNB domain; Region: RNB; pfam00773 869729006501 S1 RNA binding domain; Region: S1; pfam00575 869729006502 RNase II stability modulator; Provisional; Region: PRK10060 869729006503 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869729006504 putative active site [active] 869729006505 heme pocket [chemical binding]; other site 869729006506 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 869729006507 metal binding site [ion binding]; metal-binding site 869729006508 active site 869729006509 I-site; other site 869729006510 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 869729006511 hypothetical protein; Provisional; Region: PRK13658 869729006512 potential frameshift: common BLAST hit: gi|218689276|ref|YP_002397488.1| DNA-binding transcriptional repressor, DeoR family 869729006513 lipoprotein; Provisional; Region: PRK10540 869729006514 translation initiation factor Sui1; Validated; Region: PRK06824 869729006515 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 869729006516 putative rRNA binding site [nucleotide binding]; other site 869729006517 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 869729006518 active site 869729006519 dimer interface [polypeptide binding]; other site 869729006520 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 869729006521 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 869729006522 TPR motif; other site 869729006523 binding surface 869729006524 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869729006525 binding surface 869729006526 TPR motif; other site 869729006527 Predicted membrane protein [Function unknown]; Region: COG3771 869729006528 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 869729006529 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 869729006530 active site 869729006531 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 869729006532 dimerization interface [polypeptide binding]; other site 869729006533 active site 869729006534 aconitate hydratase; Validated; Region: PRK09277 869729006535 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 869729006536 substrate binding site [chemical binding]; other site 869729006537 ligand binding site [chemical binding]; other site 869729006538 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 869729006539 substrate binding site [chemical binding]; other site 869729006540 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 869729006541 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729006542 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 869729006543 substrate binding site [chemical binding]; other site 869729006544 putative dimerization interface [polypeptide binding]; other site 869729006545 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 869729006546 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 869729006547 active site 869729006548 interdomain interaction site; other site 869729006549 putative metal-binding site [ion binding]; other site 869729006550 nucleotide binding site [chemical binding]; other site 869729006551 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 869729006552 domain I; other site 869729006553 DNA binding groove [nucleotide binding] 869729006554 phosphate binding site [ion binding]; other site 869729006555 domain II; other site 869729006556 domain III; other site 869729006557 nucleotide binding site [chemical binding]; other site 869729006558 catalytic site [active] 869729006559 domain IV; other site 869729006560 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 869729006561 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 869729006562 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 869729006563 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 869729006564 hypothetical protein; Provisional; Region: PRK11037 869729006565 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 869729006566 putative inner membrane peptidase; Provisional; Region: PRK11778 869729006567 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 869729006568 tandem repeat interface [polypeptide binding]; other site 869729006569 oligomer interface [polypeptide binding]; other site 869729006570 active site residues [active] 869729006571 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 869729006572 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 869729006573 NADP binding site [chemical binding]; other site 869729006574 homodimer interface [polypeptide binding]; other site 869729006575 active site 869729006576 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 869729006577 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 869729006578 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 869729006579 homodimer interface [polypeptide binding]; other site 869729006580 Walker A motif; other site 869729006581 ATP binding site [chemical binding]; other site 869729006582 hydroxycobalamin binding site [chemical binding]; other site 869729006583 Walker B motif; other site 869729006584 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 869729006585 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869729006586 RNA binding surface [nucleotide binding]; other site 869729006587 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 869729006588 probable active site [active] 869729006589 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 869729006590 hypothetical protein; Provisional; Region: PRK11630 869729006591 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 869729006592 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 869729006593 active site 869729006594 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 869729006595 anthranilate synthase component I; Provisional; Region: PRK13564 869729006596 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 869729006597 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 869729006598 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 869729006599 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 869729006600 glutamine binding [chemical binding]; other site 869729006601 catalytic triad [active] 869729006602 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 869729006603 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 869729006604 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 869729006605 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 869729006606 active site 869729006607 ribulose/triose binding site [chemical binding]; other site 869729006608 phosphate binding site [ion binding]; other site 869729006609 substrate (anthranilate) binding pocket [chemical binding]; other site 869729006610 product (indole) binding pocket [chemical binding]; other site 869729006611 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 869729006612 active site 869729006613 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 869729006614 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 869729006615 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729006616 catalytic residue [active] 869729006617 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 869729006618 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 869729006619 substrate binding site [chemical binding]; other site 869729006620 active site 869729006621 catalytic residues [active] 869729006622 heterodimer interface [polypeptide binding]; other site 869729006623 General stress protein [General function prediction only]; Region: GsiB; COG3729 869729006624 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 869729006625 dimerization interface [polypeptide binding]; other site 869729006626 metal binding site [ion binding]; metal-binding site 869729006627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 869729006628 OmpW family; Region: OmpW; cl17427 869729006629 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 869729006630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 869729006631 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 869729006632 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 869729006633 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 869729006634 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 869729006635 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 869729006636 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 869729006637 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 869729006638 Phage Tail Collar Domain; Region: Collar; pfam07484 869729006639 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 869729006640 Phage-related protein, tail component [Function unknown]; Region: COG4733 869729006641 Putative phage tail protein; Region: Phage-tail_3; pfam13550 869729006642 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 869729006643 Fibronectin type III protein; Region: DUF3672; pfam12421 869729006644 Phage-related protein, tail component [Function unknown]; Region: COG4723 869729006645 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 869729006646 MPN+ (JAMM) motif; other site 869729006647 Zinc-binding site [ion binding]; other site 869729006648 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 869729006649 NlpC/P60 family; Region: NLPC_P60; cl17555 869729006650 Phage-related protein [Function unknown]; Region: gp18; COG4672 869729006651 Phage-related protein [Function unknown]; Region: COG4718 869729006652 Phage-related minor tail protein [Function unknown]; Region: COG5281 869729006653 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 869729006654 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 869729006655 Minor tail protein T; Region: Phage_tail_T; cl05636 869729006656 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 869729006657 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 869729006658 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 869729006659 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 869729006660 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 869729006661 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 869729006662 DNA packaging protein FI; Region: Packaging_FI; pfam14000 869729006663 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 869729006664 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 869729006665 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 869729006666 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 869729006667 tandem repeat interface [polypeptide binding]; other site 869729006668 oligomer interface [polypeptide binding]; other site 869729006669 active site residues [active] 869729006670 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 869729006671 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 869729006672 gpW; Region: gpW; pfam02831 869729006673 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 869729006674 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 869729006675 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 869729006676 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 869729006677 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 869729006678 catalytic residues [active] 869729006679 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 869729006680 Lysis protein S; Region: Lysis_S; pfam04971 869729006681 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 869729006682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729006683 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 869729006684 DNA methylase; Region: N6_N4_Mtase; pfam01555 869729006685 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 869729006686 Antitermination protein; Region: Antiterm; pfam03589 869729006687 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 869729006688 Protein of unknown function (DUF968); Region: DUF968; pfam06147 869729006689 Hok/gef family; Region: HOK_GEF; pfam01848 869729006690 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 869729006691 primosomal protein DnaI; Provisional; Region: PRK02854 869729006692 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 869729006693 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 869729006694 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869729006695 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 869729006696 non-specific DNA binding site [nucleotide binding]; other site 869729006697 salt bridge; other site 869729006698 sequence-specific DNA binding site [nucleotide binding]; other site 869729006699 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 869729006700 Catalytic site [active] 869729006701 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 869729006702 DicB protein; Region: DicB; pfam05358 869729006703 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 869729006704 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 869729006705 active site 869729006706 catalytic site [active] 869729006707 substrate binding site [chemical binding]; other site 869729006708 potential frameshift: common BLAST hit: gi|260868017|ref|YP_003234419.1| putative integrase 869729006709 outer membrane protein W; Provisional; Region: PRK10959 869729006710 hypothetical protein; Provisional; Region: PRK02868 869729006711 intracellular septation protein A; Reviewed; Region: PRK00259 869729006712 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 869729006713 transport protein TonB; Provisional; Region: PRK10819 869729006714 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 869729006715 YciI-like protein; Reviewed; Region: PRK11370 869729006716 voltage-gated potassium channel; Provisional; Region: PRK10537 869729006717 Ion channel; Region: Ion_trans_2; pfam07885 869729006718 TrkA-N domain; Region: TrkA_N; pfam02254 869729006719 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 869729006720 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 869729006721 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 869729006722 putative active site [active] 869729006723 catalytic site [active] 869729006724 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 869729006725 putative active site [active] 869729006726 catalytic site [active] 869729006727 dsDNA-mimic protein; Reviewed; Region: PRK05094 869729006728 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 869729006729 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869729006730 Walker A/P-loop; other site 869729006731 ATP binding site [chemical binding]; other site 869729006732 Q-loop/lid; other site 869729006733 ABC transporter signature motif; other site 869729006734 Walker B; other site 869729006735 D-loop; other site 869729006736 H-loop/switch region; other site 869729006737 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 869729006738 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 869729006739 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869729006740 Walker A/P-loop; other site 869729006741 ATP binding site [chemical binding]; other site 869729006742 Q-loop/lid; other site 869729006743 ABC transporter signature motif; other site 869729006744 Walker B; other site 869729006745 D-loop; other site 869729006746 H-loop/switch region; other site 869729006747 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 869729006748 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 869729006749 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 869729006750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729006751 dimer interface [polypeptide binding]; other site 869729006752 conserved gate region; other site 869729006753 putative PBP binding loops; other site 869729006754 ABC-ATPase subunit interface; other site 869729006755 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 869729006756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729006757 dimer interface [polypeptide binding]; other site 869729006758 conserved gate region; other site 869729006759 putative PBP binding loops; other site 869729006760 ABC-ATPase subunit interface; other site 869729006761 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 869729006762 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 869729006763 peptide binding site [polypeptide binding]; other site 869729006764 hypothetical protein; Provisional; Region: PRK11111 869729006765 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 869729006766 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 869729006767 putative catalytic cysteine [active] 869729006768 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 869729006769 putative active site [active] 869729006770 metal binding site [ion binding]; metal-binding site 869729006771 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 869729006772 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 869729006773 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869729006774 thymidine kinase; Provisional; Region: PRK04296 869729006775 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 869729006776 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 869729006777 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 869729006778 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 869729006779 active site 869729006780 tetramer interface; other site 869729006781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729006782 active site 869729006783 response regulator of RpoS; Provisional; Region: PRK10693 869729006784 phosphorylation site [posttranslational modification] 869729006785 intermolecular recognition site; other site 869729006786 dimerization interface [polypeptide binding]; other site 869729006787 hypothetical protein; Provisional; Region: PRK10279 869729006788 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 869729006789 active site 869729006790 nucleophile elbow; other site 869729006791 hypothetical protein; Provisional; Region: PRK01617 869729006792 SEC-C motif; Region: SEC-C; pfam02810 869729006793 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 869729006794 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 869729006795 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 869729006796 putative active site [active] 869729006797 putative substrate binding site [chemical binding]; other site 869729006798 putative cosubstrate binding site; other site 869729006799 catalytic site [active] 869729006800 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869729006801 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 869729006802 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 869729006803 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 869729006804 4Fe-4S binding domain; Region: Fer4; cl02805 869729006805 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 869729006806 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 869729006807 [4Fe-4S] binding site [ion binding]; other site 869729006808 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 869729006809 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 869729006810 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 869729006811 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 869729006812 molybdopterin cofactor binding site; other site 869729006813 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 869729006814 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 869729006815 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 869729006816 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869729006817 dimerization interface [polypeptide binding]; other site 869729006818 Histidine kinase; Region: HisKA_3; pfam07730 869729006819 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729006820 ATP binding site [chemical binding]; other site 869729006821 Mg2+ binding site [ion binding]; other site 869729006822 G-X-G motif; other site 869729006823 transcriptional regulator NarL; Provisional; Region: PRK10651 869729006824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729006825 active site 869729006826 phosphorylation site [posttranslational modification] 869729006827 intermolecular recognition site; other site 869729006828 dimerization interface [polypeptide binding]; other site 869729006829 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869729006830 DNA binding residues [nucleotide binding] 869729006831 dimerization interface [polypeptide binding]; other site 869729006832 putative invasin; Provisional; Region: PRK10177 869729006833 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 869729006834 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 869729006835 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 869729006836 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 869729006837 putative active site pocket [active] 869729006838 dimerization interface [polypeptide binding]; other site 869729006839 putative catalytic residue [active] 869729006840 cation transport regulator; Reviewed; Region: chaB; PRK09582 869729006841 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 869729006842 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 869729006843 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 869729006844 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 869729006845 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 869729006846 hypothetical protein; Provisional; Region: PRK10941 869729006847 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 869729006848 hypothetical protein; Provisional; Region: PRK10278 869729006849 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 869729006850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729006851 peptide chain release factor 1; Validated; Region: prfA; PRK00591 869729006852 This domain is found in peptide chain release factors; Region: PCRF; smart00937 869729006853 RF-1 domain; Region: RF-1; pfam00472 869729006854 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 869729006855 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 869729006856 tRNA; other site 869729006857 putative tRNA binding site [nucleotide binding]; other site 869729006858 putative NADP binding site [chemical binding]; other site 869729006859 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 869729006860 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 869729006861 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 869729006862 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 869729006863 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 869729006864 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 869729006865 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 869729006866 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 869729006867 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869729006868 active site 869729006869 putative transporter; Provisional; Region: PRK11660 869729006870 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 869729006871 Sulfate transporter family; Region: Sulfate_transp; pfam00916 869729006872 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 869729006873 hypothetical protein; Provisional; Region: PRK10692 869729006874 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 869729006875 putative active site [active] 869729006876 catalytic residue [active] 869729006877 GTP-binding protein YchF; Reviewed; Region: PRK09601 869729006878 YchF GTPase; Region: YchF; cd01900 869729006879 G1 box; other site 869729006880 GTP/Mg2+ binding site [chemical binding]; other site 869729006881 Switch I region; other site 869729006882 G2 box; other site 869729006883 Switch II region; other site 869729006884 G3 box; other site 869729006885 G4 box; other site 869729006886 G5 box; other site 869729006887 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 869729006888 Probable pectinesterase/pectinesterase inhibitor; Region: PLN02708 869729006889 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 869729006890 PAS domain; Region: PAS; smart00091 869729006891 putative active site [active] 869729006892 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729006893 Walker A motif; other site 869729006894 ATP binding site [chemical binding]; other site 869729006895 Walker B motif; other site 869729006896 arginine finger; other site 869729006897 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 869729006898 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 869729006899 Dak1 domain; Region: Dak1; pfam02733 869729006900 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 869729006901 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 869729006902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 869729006903 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 869729006904 dimerization domain swap beta strand [polypeptide binding]; other site 869729006905 regulatory protein interface [polypeptide binding]; other site 869729006906 active site 869729006907 regulatory phosphorylation site [posttranslational modification]; other site 869729006908 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 869729006909 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 869729006910 trehalase; Provisional; Region: treA; PRK13271 869729006911 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 869729006912 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 869729006913 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 869729006914 putative metal binding site [ion binding]; other site 869729006915 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 869729006916 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869729006917 ABC-ATPase subunit interface; other site 869729006918 dimer interface [polypeptide binding]; other site 869729006919 putative PBP binding regions; other site 869729006920 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 869729006921 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 869729006922 Walker A/P-loop; other site 869729006923 ATP binding site [chemical binding]; other site 869729006924 Q-loop/lid; other site 869729006925 ABC transporter signature motif; other site 869729006926 Walker B; other site 869729006927 D-loop; other site 869729006928 H-loop/switch region; other site 869729006929 Methyltransferase domain; Region: Methyltransf_31; pfam13847 869729006930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729006931 S-adenosylmethionine binding site [chemical binding]; other site 869729006932 molybdenum transport protein ModD; Provisional; Region: PRK06096 869729006933 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 869729006934 dimerization interface [polypeptide binding]; other site 869729006935 active site 869729006936 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 869729006937 N-terminal plug; other site 869729006938 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 869729006939 ligand-binding site [chemical binding]; other site 869729006940 hypothetical protein; Provisional; Region: PRK10457 869729006941 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 869729006942 Flagellar regulator YcgR; Region: YcgR; pfam07317 869729006943 PilZ domain; Region: PilZ; pfam07238 869729006944 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 869729006945 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 869729006946 N-acetyl-D-glucosamine binding site [chemical binding]; other site 869729006947 catalytic residue [active] 869729006948 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 869729006949 dimer interface [polypeptide binding]; other site 869729006950 catalytic triad [active] 869729006951 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 869729006952 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 869729006953 TrkA-C domain; Region: TrkA_C; pfam02080 869729006954 Transporter associated domain; Region: CorC_HlyC; smart01091 869729006955 alanine racemase; Reviewed; Region: dadX; PRK03646 869729006956 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 869729006957 active site 869729006958 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869729006959 substrate binding site [chemical binding]; other site 869729006960 catalytic residues [active] 869729006961 dimer interface [polypeptide binding]; other site 869729006962 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 869729006963 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869729006964 SpoVR family protein; Provisional; Region: PRK11767 869729006965 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 869729006966 fatty acid metabolism regulator; Provisional; Region: PRK04984 869729006967 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869729006968 DNA-binding site [nucleotide binding]; DNA binding site 869729006969 FadR C-terminal domain; Region: FadR_C; pfam07840 869729006970 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 869729006971 transmembrane helices; other site 869729006972 disulfide bond formation protein B; Provisional; Region: PRK01749 869729006973 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 869729006974 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 869729006975 active site 869729006976 DNA binding site [nucleotide binding] 869729006977 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 869729006978 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 869729006979 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 869729006980 Catalytic site [active] 869729006981 Haemolysin E (HlyE); Region: HlyE; cl11627 869729006982 hypothetical protein; Provisional; Region: PRK05170 869729006983 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 869729006984 hypothetical protein; Provisional; Region: PRK10691 869729006985 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 869729006986 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 869729006987 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 869729006988 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 869729006989 septum formation inhibitor; Reviewed; Region: minC; PRK03511 869729006990 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 869729006991 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 869729006992 cell division inhibitor MinD; Provisional; Region: PRK10818 869729006993 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 869729006994 Switch I; other site 869729006995 Switch II; other site 869729006996 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 869729006997 Autotransporter beta-domain; Region: Autotransporter; smart00869 869729006998 Autotransporter beta-domain; Region: Autotransporter; cl17461 869729006999 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 869729007000 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 869729007001 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 869729007002 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 869729007003 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 869729007004 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 869729007005 Sensors of blue-light using FAD; Region: BLUF; smart01034 869729007006 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 869729007007 transcriptional regulator MirA; Provisional; Region: PRK15043 869729007008 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 869729007009 DNA binding residues [nucleotide binding] 869729007010 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 869729007011 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 869729007012 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 869729007013 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 869729007014 metal binding site [ion binding]; metal-binding site 869729007015 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 869729007016 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 869729007017 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 869729007018 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869729007019 ABC-ATPase subunit interface; other site 869729007020 dimer interface [polypeptide binding]; other site 869729007021 putative PBP binding regions; other site 869729007022 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 869729007023 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869729007024 ABC-ATPase subunit interface; other site 869729007025 dimer interface [polypeptide binding]; other site 869729007026 putative PBP binding regions; other site 869729007027 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 869729007028 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 869729007029 Phage-related protein, tail component [Function unknown]; Region: COG4733 869729007030 Putative phage tail protein; Region: Phage-tail_3; pfam13550 869729007031 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 869729007032 Fibronectin type III protein; Region: DUF3672; pfam12421 869729007033 Phage-related protein, tail component [Function unknown]; Region: COG4723 869729007034 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 869729007035 MPN+ (JAMM) motif; other site 869729007036 Zinc-binding site [ion binding]; other site 869729007037 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 869729007038 NlpC/P60 family; Region: NLPC_P60; cl17555 869729007039 Phage-related protein [Function unknown]; Region: gp18; COG4672 869729007040 Phage-related protein [Function unknown]; Region: COG4718 869729007041 Phage-related minor tail protein [Function unknown]; Region: COG5281 869729007042 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 869729007043 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 869729007044 Minor tail protein T; Region: Phage_tail_T; cl05636 869729007045 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 869729007046 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 869729007047 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 869729007048 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 869729007049 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 869729007050 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 869729007051 DNA packaging protein FI; Region: Packaging_FI; pfam14000 869729007052 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 869729007053 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 869729007054 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 869729007055 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 869729007056 tandem repeat interface [polypeptide binding]; other site 869729007057 oligomer interface [polypeptide binding]; other site 869729007058 active site residues [active] 869729007059 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 869729007060 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 869729007061 gpW; Region: gpW; pfam02831 869729007062 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 869729007063 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 869729007064 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 869729007065 Bor protein; Region: Lambda_Bor; pfam06291 869729007066 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 869729007067 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 869729007068 catalytic residues [active] 869729007069 Lysis protein S; Region: Lysis_S; pfam04971 869729007070 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 869729007071 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 869729007072 trimer interface [polypeptide binding]; other site 869729007073 eyelet of channel; other site 869729007074 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 869729007075 endodeoxyribonuclease RUS; Reviewed; Region: PRK09786 869729007076 NinF protein; Region: NinF; pfam05810 869729007077 Protein of unknown function (DUF2591); Region: DUF2591; cl11584 869729007078 NINE Protein; Region: NinE; pfam05322 869729007079 phage N-6-adenine-methyltransferase; Region: phage_N6A_met; TIGR01712 869729007080 NinB protein; Region: NinB; pfam05772 869729007081 Replication protein P; Region: Phage_lambda_P; pfam06992 869729007082 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 869729007083 Bacteriophage CII protein; Region: Phage_CII; pfam05269 869729007084 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869729007085 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869729007086 non-specific DNA binding site [nucleotide binding]; other site 869729007087 salt bridge; other site 869729007088 sequence-specific DNA binding site [nucleotide binding]; other site 869729007089 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 869729007090 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869729007091 non-specific DNA binding site [nucleotide binding]; other site 869729007092 salt bridge; other site 869729007093 sequence-specific DNA binding site [nucleotide binding]; other site 869729007094 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 869729007095 Catalytic site [active] 869729007096 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 869729007097 Superinfection exclusion protein B; Region: SieB; pfam14163 869729007098 Antirestriction protein Ral; Region: Ral; pfam11058 869729007099 Protein of unknown function (DUF2528); Region: DUF2528; pfam10800 869729007100 Lambda Phage CIII; Region: Lambda_CIII; pfam02061 869729007101 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 869729007102 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 869729007103 phage recombination protein Bet; Region: bet_lambda; TIGR01913 869729007104 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 869729007105 Protein of unknown function (DUF1317); Region: DUF1317; pfam07026 869729007106 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 869729007107 DksA-like zinc finger domain containing protein; Region: PHA00080 869729007108 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 869729007109 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 869729007110 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 869729007111 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 869729007112 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 869729007113 dimer interface [polypeptide binding]; other site 869729007114 active site 869729007115 Int/Topo IB signature motif; other site 869729007116 isocitrate dehydrogenase; Validated; Region: PRK07362 869729007117 isocitrate dehydrogenase; Reviewed; Region: PRK07006 869729007118 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 869729007119 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 869729007120 probable active site [active] 869729007121 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 869729007122 nudix motif; other site 869729007123 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 869729007124 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 869729007125 putative lysogenization regulator; Reviewed; Region: PRK00218 869729007126 adenylosuccinate lyase; Provisional; Region: PRK09285 869729007127 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 869729007128 tetramer interface [polypeptide binding]; other site 869729007129 active site 869729007130 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 869729007131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729007132 active site 869729007133 phosphorylation site [posttranslational modification] 869729007134 intermolecular recognition site; other site 869729007135 dimerization interface [polypeptide binding]; other site 869729007136 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869729007137 DNA binding site [nucleotide binding] 869729007138 sensor protein PhoQ; Provisional; Region: PRK10815 869729007139 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 869729007140 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 869729007141 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 869729007142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729007143 ATP binding site [chemical binding]; other site 869729007144 Mg2+ binding site [ion binding]; other site 869729007145 G-X-G motif; other site 869729007146 Uncharacterized conserved protein [Function unknown]; Region: COG2850 869729007147 Cupin-like domain; Region: Cupin_8; pfam13621 869729007148 potential frameshift: common BLAST hit: gi|209398016|ref|YP_002270027.1| peptidase T 869729007149 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 869729007150 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 869729007151 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 869729007152 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869729007153 Walker A/P-loop; other site 869729007154 ATP binding site [chemical binding]; other site 869729007155 Q-loop/lid; other site 869729007156 ABC transporter signature motif; other site 869729007157 Walker B; other site 869729007158 D-loop; other site 869729007159 H-loop/switch region; other site 869729007160 TOBE domain; Region: TOBE_2; pfam08402 869729007161 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 869729007162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729007163 dimer interface [polypeptide binding]; other site 869729007164 conserved gate region; other site 869729007165 putative PBP binding loops; other site 869729007166 ABC-ATPase subunit interface; other site 869729007167 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 869729007168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729007169 dimer interface [polypeptide binding]; other site 869729007170 conserved gate region; other site 869729007171 putative PBP binding loops; other site 869729007172 ABC-ATPase subunit interface; other site 869729007173 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 869729007174 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 869729007175 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 869729007176 NAD-dependent deacetylase; Provisional; Region: PRK00481 869729007177 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 869729007178 NAD+ binding site [chemical binding]; other site 869729007179 substrate binding site [chemical binding]; other site 869729007180 Zn binding site [ion binding]; other site 869729007181 fructokinase; Reviewed; Region: PRK09557 869729007182 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 869729007183 nucleotide binding site [chemical binding]; other site 869729007184 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 869729007185 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 869729007186 FtsX-like permease family; Region: FtsX; pfam02687 869729007187 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 869729007188 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869729007189 Walker A/P-loop; other site 869729007190 ATP binding site [chemical binding]; other site 869729007191 Q-loop/lid; other site 869729007192 ABC transporter signature motif; other site 869729007193 Walker B; other site 869729007194 D-loop; other site 869729007195 H-loop/switch region; other site 869729007196 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 869729007197 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 869729007198 FtsX-like permease family; Region: FtsX; pfam02687 869729007199 Predicted membrane protein [Function unknown]; Region: COG4763 869729007200 Acyltransferase family; Region: Acyl_transf_3; pfam01757 869729007201 transcription-repair coupling factor; Provisional; Region: PRK10689 869729007202 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 869729007203 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869729007204 ATP binding site [chemical binding]; other site 869729007205 putative Mg++ binding site [ion binding]; other site 869729007206 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869729007207 nucleotide binding region [chemical binding]; other site 869729007208 ATP-binding site [chemical binding]; other site 869729007209 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 869729007210 L,D-transpeptidase; Provisional; Region: PRK10260 869729007211 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869729007212 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 869729007213 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 869729007214 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869729007215 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869729007216 hypothetical protein; Provisional; Region: PRK11280 869729007217 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 869729007218 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869729007219 hypothetical protein; Provisional; Region: PRK04940 869729007220 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 869729007221 beta-hexosaminidase; Provisional; Region: PRK05337 869729007222 thiamine kinase; Region: ycfN_thiK; TIGR02721 869729007223 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 869729007224 active site 869729007225 substrate binding site [chemical binding]; other site 869729007226 ATP binding site [chemical binding]; other site 869729007227 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 869729007228 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 869729007229 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 869729007230 putative dimer interface [polypeptide binding]; other site 869729007231 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 869729007232 nucleotide binding site/active site [active] 869729007233 HIT family signature motif; other site 869729007234 catalytic residue [active] 869729007235 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 869729007236 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 869729007237 N-terminal plug; other site 869729007238 ligand-binding site [chemical binding]; other site 869729007239 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 869729007240 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869729007241 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869729007242 active site turn [active] 869729007243 phosphorylation site [posttranslational modification] 869729007244 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 869729007245 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 869729007246 active site 869729007247 DNA polymerase III subunit delta'; Validated; Region: PRK07993 869729007248 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 869729007249 thymidylate kinase; Validated; Region: tmk; PRK00698 869729007250 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 869729007251 TMP-binding site; other site 869729007252 ATP-binding site [chemical binding]; other site 869729007253 conserved hypothetical protein, YceG family; Region: TIGR00247 869729007254 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 869729007255 dimerization interface [polypeptide binding]; other site 869729007256 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 869729007257 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 869729007258 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729007259 catalytic residue [active] 869729007260 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 869729007261 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 869729007262 dimer interface [polypeptide binding]; other site 869729007263 active site 869729007264 acyl carrier protein; Provisional; Region: acpP; PRK00982 869729007265 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 869729007266 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 869729007267 NAD(P) binding site [chemical binding]; other site 869729007268 homotetramer interface [polypeptide binding]; other site 869729007269 homodimer interface [polypeptide binding]; other site 869729007270 active site 869729007271 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 869729007272 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 869729007273 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 869729007274 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 869729007275 dimer interface [polypeptide binding]; other site 869729007276 active site 869729007277 CoA binding pocket [chemical binding]; other site 869729007278 putative phosphate acyltransferase; Provisional; Region: PRK05331 869729007279 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 869729007280 hypothetical protein; Provisional; Region: PRK11193 869729007281 Maf-like protein; Region: Maf; pfam02545 869729007282 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 869729007283 active site 869729007284 dimer interface [polypeptide binding]; other site 869729007285 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 869729007286 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869729007287 RNA binding surface [nucleotide binding]; other site 869729007288 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 869729007289 active site 869729007290 Protein of unknown function (DUF2655); Region: DUF2655; pfam10848 869729007291 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 869729007292 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 869729007293 homodimer interface [polypeptide binding]; other site 869729007294 oligonucleotide binding site [chemical binding]; other site 869729007295 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 869729007296 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 869729007297 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 869729007298 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 869729007299 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 869729007300 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 869729007301 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 869729007302 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 869729007303 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 869729007304 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 869729007305 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 869729007306 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 869729007307 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 869729007308 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 869729007309 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 869729007310 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 869729007311 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 869729007312 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 869729007313 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 869729007314 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 869729007315 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 869729007316 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 869729007317 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 869729007318 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 869729007319 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 869729007320 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 869729007321 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 869729007322 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 869729007323 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 869729007324 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 869729007325 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 869729007326 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 869729007327 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 869729007328 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 869729007329 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 869729007330 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 869729007331 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 869729007332 MviN-like protein; Region: MVIN; pfam03023 869729007333 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 869729007334 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 869729007335 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 869729007336 hypothetical protein; Provisional; Region: PRK11239 869729007337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 869729007338 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 869729007339 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 869729007340 multidrug resistance protein MdtH; Provisional; Region: PRK11646 869729007341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729007342 putative substrate translocation pore; other site 869729007343 glutaredoxin 2; Provisional; Region: PRK10387 869729007344 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 869729007345 C-terminal domain interface [polypeptide binding]; other site 869729007346 GSH binding site (G-site) [chemical binding]; other site 869729007347 catalytic residues [active] 869729007348 putative dimer interface [polypeptide binding]; other site 869729007349 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 869729007350 N-terminal domain interface [polypeptide binding]; other site 869729007351 lipoprotein; Provisional; Region: PRK10598 869729007352 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 869729007353 active site 869729007354 substrate binding pocket [chemical binding]; other site 869729007355 dimer interface [polypeptide binding]; other site 869729007356 DNA damage-inducible protein I; Provisional; Region: PRK10597 869729007357 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 869729007358 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 869729007359 hydroxyglutarate oxidase; Provisional; Region: PRK11728 869729007360 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 869729007361 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 869729007362 hypothetical protein; Provisional; Region: PRK03757 869729007363 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 869729007364 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 869729007365 active site residue [active] 869729007366 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 869729007367 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 869729007368 putative acyl-acceptor binding pocket; other site 869729007369 drug efflux system protein MdtG; Provisional; Region: PRK09874 869729007370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729007371 putative substrate translocation pore; other site 869729007372 secY/secA suppressor protein; Provisional; Region: PRK11467 869729007373 lipoprotein; Provisional; Region: PRK10175 869729007374 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 869729007375 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 869729007376 Ligand binding site; other site 869729007377 DXD motif; other site 869729007378 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 869729007379 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 869729007380 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 869729007381 Acyltransferase family; Region: Acyl_transf_3; pfam01757 869729007382 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 869729007383 PLD-like domain; Region: PLDc_2; pfam13091 869729007384 putative active site [active] 869729007385 catalytic site [active] 869729007386 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 869729007387 PLD-like domain; Region: PLDc_2; pfam13091 869729007388 putative active site [active] 869729007389 catalytic site [active] 869729007390 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 869729007391 putative ADP-ribose binding site [chemical binding]; other site 869729007392 putative active site [active] 869729007393 Fimbrial protein; Region: Fimbrial; cl01416 869729007394 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 869729007395 major curlin subunit; Provisional; Region: csgA; PRK10051 869729007396 Curlin associated repeat; Region: Curlin_rpt; pfam07012 869729007397 Curlin associated repeat; Region: Curlin_rpt; pfam07012 869729007398 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 869729007399 Curlin associated repeat; Region: Curlin_rpt; pfam07012 869729007400 Curlin associated repeat; Region: Curlin_rpt; pfam07012 869729007401 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 869729007402 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869729007403 DNA binding residues [nucleotide binding] 869729007404 dimerization interface [polypeptide binding]; other site 869729007405 curli assembly protein CsgE; Provisional; Region: PRK10386 869729007406 curli assembly protein CsgF; Provisional; Region: PRK10050 869729007407 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 869729007408 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 869729007409 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 869729007410 putative hydrolase; Validated; Region: PRK09248 869729007411 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 869729007412 active site 869729007413 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 869729007414 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 869729007415 putative ligand binding site [chemical binding]; other site 869729007416 NAD binding site [chemical binding]; other site 869729007417 dimerization interface [polypeptide binding]; other site 869729007418 catalytic site [active] 869729007419 Methyltransferase domain; Region: Methyltransf_27; pfam13708 869729007420 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 869729007421 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 869729007422 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 869729007423 Protein of unknown function (DUF987); Region: DUF987; pfam06174 869729007424 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 869729007425 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 869729007426 MPN+ (JAMM) motif; other site 869729007427 Zinc-binding site [ion binding]; other site 869729007428 Antirestriction protein; Region: Antirestrict; pfam03230 869729007429 Domain of unknown function (DUF932); Region: DUF932; pfam06067 869729007430 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 869729007431 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 869729007432 hypothetical protein; Provisional; Region: PRK09945 869729007433 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 869729007434 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 869729007435 Autotransporter beta-domain; Region: Autotransporter; smart00869 869729007436 Predicted GTPase [General function prediction only]; Region: COG3596 869729007437 YfjP GTPase; Region: YfjP; cd11383 869729007438 G1 box; other site 869729007439 GTP/Mg2+ binding site [chemical binding]; other site 869729007440 Switch I region; other site 869729007441 G2 box; other site 869729007442 Switch II region; other site 869729007443 G3 box; other site 869729007444 G4 box; other site 869729007445 G5 box; other site 869729007446 Sel1-like repeats; Region: SEL1; smart00671 869729007447 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 869729007448 Sel1-like repeats; Region: SEL1; smart00671 869729007449 Sel1-like repeats; Region: SEL1; smart00671 869729007450 Sel1-like repeats; Region: SEL1; smart00671 869729007451 Sel1-like repeats; Region: SEL1; smart00671 869729007452 Sel1-like repeats; Region: SEL1; smart00671 869729007453 Sel1-like repeats; Region: SEL1; smart00671 869729007454 Sel1-like repeats; Region: SEL1; smart00671 869729007455 Sel1-like repeats; Region: SEL1; smart00671 869729007456 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 869729007457 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 869729007458 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 869729007459 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 869729007460 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 869729007461 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 869729007462 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 869729007463 N-terminal plug; other site 869729007464 ligand-binding site [chemical binding]; other site 869729007465 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 869729007466 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 869729007467 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 869729007468 homodimer interface [polypeptide binding]; other site 869729007469 active site 869729007470 TDP-binding site; other site 869729007471 acceptor substrate-binding pocket; other site 869729007472 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869729007473 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869729007474 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869729007475 Walker A/P-loop; other site 869729007476 ATP binding site [chemical binding]; other site 869729007477 Q-loop/lid; other site 869729007478 ABC transporter signature motif; other site 869729007479 Walker B; other site 869729007480 D-loop; other site 869729007481 H-loop/switch region; other site 869729007482 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869729007483 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869729007484 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869729007485 Walker A/P-loop; other site 869729007486 ATP binding site [chemical binding]; other site 869729007487 Q-loop/lid; other site 869729007488 ABC transporter signature motif; other site 869729007489 Walker B; other site 869729007490 D-loop; other site 869729007491 H-loop/switch region; other site 869729007492 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 869729007493 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 869729007494 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 869729007495 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 869729007496 outer membrane receptor FepA; Provisional; Region: PRK13528 869729007497 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 869729007498 N-terminal plug; other site 869729007499 ligand-binding site [chemical binding]; other site 869729007500 MarR family; Region: MarR_2; cl17246 869729007501 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 869729007502 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 869729007503 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 869729007504 mannosyl binding site [chemical binding]; other site 869729007505 Fimbrial protein; Region: Fimbrial; pfam00419 869729007506 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 869729007507 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 869729007508 outer membrane usher protein; Provisional; Region: PRK15193 869729007509 PapC N-terminal domain; Region: PapC_N; pfam13954 869729007510 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 869729007511 PapC C-terminal domain; Region: PapC_C; pfam13953 869729007512 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 869729007513 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 869729007514 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 869729007515 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 869729007516 Fimbrial protein; Region: Fimbrial; cl01416 869729007517 Adhesin biosynthesis transcription regulatory protein; Region: PapB; pfam03333 869729007518 FaeA-like protein; Region: FaeA; pfam04703 869729007519 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; cl17802 869729007520 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; cl17802 869729007521 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; cl17802 869729007522 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869729007523 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 869729007524 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 869729007525 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 869729007526 putative active site [active] 869729007527 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 869729007528 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 869729007529 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 869729007530 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869729007531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729007532 homodimer interface [polypeptide binding]; other site 869729007533 catalytic residue [active] 869729007534 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 869729007535 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 869729007536 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 869729007537 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 869729007538 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 869729007539 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 869729007540 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 869729007541 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 869729007542 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 869729007543 integrase; Provisional; Region: PRK09692 869729007544 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 869729007545 active site 869729007546 Int/Topo IB signature motif; other site 869729007547 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 869729007548 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 869729007549 metal binding site [ion binding]; metal-binding site 869729007550 active site 869729007551 I-site; other site 869729007552 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 869729007553 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 869729007554 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 869729007555 putative active site [active] 869729007556 putative metal binding site [ion binding]; other site 869729007557 N-glycosyltransferase; Provisional; Region: PRK11204 869729007558 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 869729007559 DXD motif; other site 869729007560 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 869729007561 putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585 869729007562 hypothetical protein; Provisional; Region: PRK10536 869729007563 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 869729007564 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 869729007565 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 869729007566 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 869729007567 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 869729007568 Imelysin; Region: Peptidase_M75; pfam09375 869729007569 FTR1 family protein; Region: TIGR00145 869729007570 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 869729007571 Na binding site [ion binding]; other site 869729007572 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 869729007573 Predicted transcriptional regulator [Transcription]; Region: COG3905 869729007574 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 869729007575 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 869729007576 Glutamate binding site [chemical binding]; other site 869729007577 NAD binding site [chemical binding]; other site 869729007578 catalytic residues [active] 869729007579 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 869729007580 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869729007581 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 869729007582 pyrimidine utilization protein A; Region: RutA; TIGR03612 869729007583 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 869729007584 active site 869729007585 dimer interface [polypeptide binding]; other site 869729007586 non-prolyl cis peptide bond; other site 869729007587 insertion regions; other site 869729007588 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 869729007589 Isochorismatase family; Region: Isochorismatase; pfam00857 869729007590 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 869729007591 catalytic triad [active] 869729007592 conserved cis-peptide bond; other site 869729007593 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 869729007594 homotrimer interaction site [polypeptide binding]; other site 869729007595 putative active site [active] 869729007596 pyrimidine utilization protein D; Region: RutD; TIGR03611 869729007597 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 869729007598 putative FMN binding site [chemical binding]; other site 869729007599 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 869729007600 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 869729007601 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 869729007602 General stress protein [General function prediction only]; Region: GsiB; COG3729 869729007603 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 869729007604 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 869729007605 hypothetical protein; Provisional; Region: PRK10174 869729007606 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 869729007607 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 869729007608 catalytic core [active] 869729007609 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 869729007610 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 869729007611 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 869729007612 HSP70 interaction site [polypeptide binding]; other site 869729007613 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 869729007614 substrate binding site [polypeptide binding]; other site 869729007615 dimer interface [polypeptide binding]; other site 869729007616 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 869729007617 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 869729007618 chaperone protein TorD; Validated; Region: torD; PRK04976 869729007619 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 869729007620 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 869729007621 molybdopterin cofactor binding site [chemical binding]; other site 869729007622 substrate binding site [chemical binding]; other site 869729007623 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 869729007624 molybdopterin cofactor binding site; other site 869729007625 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 869729007626 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 869729007627 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 869729007628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729007629 active site 869729007630 phosphorylation site [posttranslational modification] 869729007631 intermolecular recognition site; other site 869729007632 dimerization interface [polypeptide binding]; other site 869729007633 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869729007634 DNA binding site [nucleotide binding] 869729007635 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 869729007636 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 869729007637 putative ligand binding site [chemical binding]; other site 869729007638 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 869729007639 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 869729007640 dimerization interface [polypeptide binding]; other site 869729007641 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869729007642 dimer interface [polypeptide binding]; other site 869729007643 phosphorylation site [posttranslational modification] 869729007644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729007645 ATP binding site [chemical binding]; other site 869729007646 Mg2+ binding site [ion binding]; other site 869729007647 G-X-G motif; other site 869729007648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729007649 active site 869729007650 phosphorylation site [posttranslational modification] 869729007651 intermolecular recognition site; other site 869729007652 dimerization interface [polypeptide binding]; other site 869729007653 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 869729007654 putative binding surface; other site 869729007655 active site 869729007656 4Fe-4S binding domain; Region: Fer4_5; pfam12801 869729007657 4Fe-4S binding domain; Region: Fer4_5; pfam12801 869729007658 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 869729007659 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 869729007660 GnsA/GnsB family; Region: GnsAB; pfam08178 869729007661 cold shock gene; Provisional; Region: PRK09891 869729007662 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 869729007663 DNA-binding site [nucleotide binding]; DNA binding site 869729007664 RNA-binding motif; other site 869729007665 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 869729007666 DNA-binding site [nucleotide binding]; DNA binding site 869729007667 RNA-binding motif; other site 869729007668 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 869729007669 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 869729007670 catalytic core [active] 869729007671 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 869729007672 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 869729007673 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 869729007674 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 869729007675 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 869729007676 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 869729007677 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 869729007678 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 869729007679 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 869729007680 putative substrate-binding site; other site 869729007681 nickel binding site [ion binding]; other site 869729007682 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 869729007683 hydrogenase 1 large subunit; Provisional; Region: PRK10170 869729007684 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 869729007685 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 869729007686 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 869729007687 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 869729007688 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 869729007689 YccA-like proteins; Region: YccA_like; cd10433 869729007690 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 869729007691 sulfur transfer protein TusE; Provisional; Region: PRK11508 869729007692 Acylphosphatase; Region: Acylphosphatase; cl00551 869729007693 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 869729007694 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 869729007695 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 869729007696 putative RNA binding site [nucleotide binding]; other site 869729007697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729007698 S-adenosylmethionine binding site [chemical binding]; other site 869729007699 heat shock protein HspQ; Provisional; Region: PRK14129 869729007700 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 869729007701 hypothetical protein; Provisional; Region: PRK03641 869729007702 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 869729007703 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 869729007704 active site 869729007705 dimer interfaces [polypeptide binding]; other site 869729007706 catalytic residues [active] 869729007707 DNA helicase IV; Provisional; Region: helD; PRK11054 869729007708 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 869729007709 Part of AAA domain; Region: AAA_19; pfam13245 869729007710 Family description; Region: UvrD_C_2; pfam13538 869729007711 Predicted membrane protein [Function unknown]; Region: COG3304 869729007712 Domain of unknown function (DUF307); Region: DUF307; pfam03733 869729007713 Domain of unknown function (DUF307); Region: DUF307; pfam03733 869729007714 TIGR01666 family membrane protein; Region: YCCS 869729007715 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 869729007716 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 869729007717 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 869729007718 TfoX C-terminal domain; Region: TfoX_C; pfam04994 869729007719 cell division inhibitor SulA; Region: sula; TIGR00623 869729007720 outer membrane protein A; Reviewed; Region: PRK10808 869729007721 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 869729007722 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 869729007723 ligand binding site [chemical binding]; other site 869729007724 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 869729007725 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 869729007726 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 869729007727 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 869729007728 active site 1 [active] 869729007729 dimer interface [polypeptide binding]; other site 869729007730 active site 2 [active] 869729007731 ribosome modulation factor; Provisional; Region: PRK14563 869729007732 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 869729007733 Protein of unknown function (DUF330); Region: DUF330; pfam03886 869729007734 paraquat-inducible protein B; Provisional; Region: PRK10807 869729007735 mce related protein; Region: MCE; pfam02470 869729007736 mce related protein; Region: MCE; pfam02470 869729007737 mce related protein; Region: MCE; pfam02470 869729007738 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 869729007739 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 869729007740 Paraquat-inducible protein A; Region: PqiA; pfam04403 869729007741 Paraquat-inducible protein A; Region: PqiA; pfam04403 869729007742 ABC transporter ATPase component; Reviewed; Region: PRK11147 869729007743 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869729007744 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869729007745 Walker A/P-loop; other site 869729007746 Walker A/P-loop; other site 869729007747 ATP binding site [chemical binding]; other site 869729007748 ATP binding site [chemical binding]; other site 869729007749 Q-loop/lid; other site 869729007750 Q-loop/lid; other site 869729007751 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869729007752 ABC transporter signature motif; other site 869729007753 Walker B; other site 869729007754 D-loop; other site 869729007755 ABC transporter; Region: ABC_tran_2; pfam12848 869729007756 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869729007757 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 869729007758 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 869729007759 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 869729007760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729007761 S-adenosylmethionine binding site [chemical binding]; other site 869729007762 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 869729007763 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 869729007764 MOSC domain; Region: MOSC; pfam03473 869729007765 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 869729007766 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 869729007767 catalytic loop [active] 869729007768 iron binding site [ion binding]; other site 869729007769 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 869729007770 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 869729007771 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 869729007772 quinone interaction residues [chemical binding]; other site 869729007773 active site 869729007774 catalytic residues [active] 869729007775 FMN binding site [chemical binding]; other site 869729007776 substrate binding site [chemical binding]; other site 869729007777 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 869729007778 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 869729007779 potential frameshift: common BLAST hit: gi|218688779|ref|YP_002396991.1| alkanesulfonate transporter substrate-binding subunit 869729007780 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 869729007781 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 869729007782 active site 869729007783 dimer interface [polypeptide binding]; other site 869729007784 non-prolyl cis peptide bond; other site 869729007785 insertion regions; other site 869729007786 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 869729007787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729007788 dimer interface [polypeptide binding]; other site 869729007789 conserved gate region; other site 869729007790 putative PBP binding loops; other site 869729007791 ABC-ATPase subunit interface; other site 869729007792 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 869729007793 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 869729007794 Walker A/P-loop; other site 869729007795 ATP binding site [chemical binding]; other site 869729007796 Q-loop/lid; other site 869729007797 ABC transporter signature motif; other site 869729007798 Walker B; other site 869729007799 D-loop; other site 869729007800 H-loop/switch region; other site 869729007801 aminopeptidase N; Provisional; Region: pepN; PRK14015 869729007802 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 869729007803 active site 869729007804 Zn binding site [ion binding]; other site 869729007805 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 869729007806 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 869729007807 active site 869729007808 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 869729007809 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 869729007810 putative dimer interface [polypeptide binding]; other site 869729007811 putative anticodon binding site; other site 869729007812 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 869729007813 homodimer interface [polypeptide binding]; other site 869729007814 motif 1; other site 869729007815 motif 2; other site 869729007816 active site 869729007817 motif 3; other site 869729007818 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 869729007819 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 869729007820 trimer interface [polypeptide binding]; other site 869729007821 eyelet of channel; other site 869729007822 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 869729007823 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869729007824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729007825 homodimer interface [polypeptide binding]; other site 869729007826 catalytic residue [active] 869729007827 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 869729007828 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 869729007829 Peptidase M15; Region: Peptidase_M15_3; cl01194 869729007830 murein L,D-transpeptidase; Provisional; Region: PRK10594 869729007831 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 869729007832 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 869729007833 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 869729007834 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 869729007835 MukB N-terminal; Region: MukB; pfam04310 869729007836 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 869729007837 condesin subunit E; Provisional; Region: PRK05256 869729007838 condesin subunit F; Provisional; Region: PRK05260 869729007839 Methyltransferase domain; Region: Methyltransf_31; pfam13847 869729007840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729007841 S-adenosylmethionine binding site [chemical binding]; other site 869729007842 Uncharacterized conserved protein [Function unknown]; Region: COG1434 869729007843 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 869729007844 putative active site [active] 869729007845 hypothetical protein; Provisional; Region: PRK10593 869729007846 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 869729007847 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 869729007848 Ligand binding site; other site 869729007849 oligomer interface; other site 869729007850 hypothetical protein; Provisional; Region: PRK11827 869729007851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 869729007852 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 869729007853 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 869729007854 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 869729007855 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 869729007856 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869729007857 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 869729007858 Walker A/P-loop; other site 869729007859 ATP binding site [chemical binding]; other site 869729007860 Q-loop/lid; other site 869729007861 ABC transporter signature motif; other site 869729007862 Walker B; other site 869729007863 D-loop; other site 869729007864 H-loop/switch region; other site 869729007865 ComEC family competence protein; Provisional; Region: PRK11539 869729007866 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 869729007867 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 869729007868 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 869729007869 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 869729007870 IHF dimer interface [polypeptide binding]; other site 869729007871 IHF - DNA interface [nucleotide binding]; other site 869729007872 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 869729007873 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 869729007874 RNA binding site [nucleotide binding]; other site 869729007875 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 869729007876 RNA binding site [nucleotide binding]; other site 869729007877 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 869729007878 RNA binding site [nucleotide binding]; other site 869729007879 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 869729007880 RNA binding site [nucleotide binding]; other site 869729007881 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 869729007882 RNA binding site [nucleotide binding]; other site 869729007883 cytidylate kinase; Provisional; Region: cmk; PRK00023 869729007884 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 869729007885 CMP-binding site; other site 869729007886 The sites determining sugar specificity; other site 869729007887 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 869729007888 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 869729007889 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 869729007890 hinge; other site 869729007891 active site 869729007892 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 869729007893 homodimer interface [polypeptide binding]; other site 869729007894 substrate-cofactor binding pocket; other site 869729007895 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729007896 catalytic residue [active] 869729007897 Predicted membrane protein [Function unknown]; Region: COG2323 869729007898 uncharacterized domain; Region: TIGR00702 869729007899 YcaO-like family; Region: YcaO; pfam02624 869729007900 formate transporter; Provisional; Region: PRK10805 869729007901 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 869729007902 Pyruvate formate lyase 1; Region: PFL1; cd01678 869729007903 coenzyme A binding site [chemical binding]; other site 869729007904 active site 869729007905 catalytic residues [active] 869729007906 glycine loop; other site 869729007907 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 869729007908 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869729007909 FeS/SAM binding site; other site 869729007910 putative MFS family transporter protein; Provisional; Region: PRK03633 869729007911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729007912 putative substrate translocation pore; other site 869729007913 Isochorismatase family; Region: Isochorismatase; pfam00857 869729007914 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 869729007915 catalytic triad [active] 869729007916 dimer interface [polypeptide binding]; other site 869729007917 conserved cis-peptide bond; other site 869729007918 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 869729007919 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 869729007920 4Fe-4S binding domain; Region: Fer4; pfam00037 869729007921 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 869729007922 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 869729007923 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 869729007924 putative [Fe4-S4] binding site [ion binding]; other site 869729007925 putative molybdopterin cofactor binding site [chemical binding]; other site 869729007926 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 869729007927 putative molybdopterin cofactor binding site; other site 869729007928 seryl-tRNA synthetase; Provisional; Region: PRK05431 869729007929 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 869729007930 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 869729007931 dimer interface [polypeptide binding]; other site 869729007932 active site 869729007933 motif 1; other site 869729007934 motif 2; other site 869729007935 motif 3; other site 869729007936 recombination factor protein RarA; Reviewed; Region: PRK13342 869729007937 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729007938 Walker A motif; other site 869729007939 ATP binding site [chemical binding]; other site 869729007940 Walker B motif; other site 869729007941 arginine finger; other site 869729007942 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 869729007943 periplasmic chaperone LolA; Region: lolA; TIGR00547 869729007944 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 869729007945 DNA translocase FtsK; Provisional; Region: PRK10263 869729007946 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 869729007947 DNA translocase FtsK; Provisional; Region: PRK10263 869729007948 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 869729007949 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 869729007950 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 869729007951 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869729007952 putative DNA binding site [nucleotide binding]; other site 869729007953 putative Zn2+ binding site [ion binding]; other site 869729007954 AsnC family; Region: AsnC_trans_reg; pfam01037 869729007955 thioredoxin reductase; Provisional; Region: PRK10262 869729007956 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869729007957 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869729007958 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 869729007959 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869729007960 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869729007961 Walker A/P-loop; other site 869729007962 ATP binding site [chemical binding]; other site 869729007963 Q-loop/lid; other site 869729007964 ABC transporter signature motif; other site 869729007965 Walker B; other site 869729007966 D-loop; other site 869729007967 H-loop/switch region; other site 869729007968 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 869729007969 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869729007970 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 869729007971 Walker A/P-loop; other site 869729007972 ATP binding site [chemical binding]; other site 869729007973 Q-loop/lid; other site 869729007974 ABC transporter signature motif; other site 869729007975 Walker B; other site 869729007976 D-loop; other site 869729007977 H-loop/switch region; other site 869729007978 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 869729007979 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 869729007980 rRNA binding site [nucleotide binding]; other site 869729007981 predicted 30S ribosome binding site; other site 869729007982 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739 869729007983 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 869729007984 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09735 869729007985 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 869729007986 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 869729007987 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-F; cd09718 869729007988 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 869729007989 Clp amino terminal domain; Region: Clp_N; pfam02861 869729007990 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729007991 Walker A motif; other site 869729007992 ATP binding site [chemical binding]; other site 869729007993 Walker B motif; other site 869729007994 arginine finger; other site 869729007995 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729007996 Walker A motif; other site 869729007997 ATP binding site [chemical binding]; other site 869729007998 Walker B motif; other site 869729007999 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 869729008000 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 869729008001 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 869729008002 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 869729008003 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 869729008004 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 869729008005 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 869729008006 ssDNA binding site [nucleotide binding]; other site 869729008007 dimer interface [polypeptide binding]; other site 869729008008 tetramer (dimer of dimers) interface [polypeptide binding]; other site 869729008009 D5 N terminal like; Region: D5_N; smart00885 869729008010 Phage associated DNA primase [General function prediction only]; Region: COG3378 869729008011 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 869729008012 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 869729008013 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 869729008014 integrase; Provisional; Region: PRK09692 869729008015 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 869729008016 active site 869729008017 Int/Topo IB signature motif; other site 869729008018 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 869729008019 DNA-binding site [nucleotide binding]; DNA binding site 869729008020 RNA-binding motif; other site 869729008021 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 869729008022 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869729008023 Walker A/P-loop; other site 869729008024 ATP binding site [chemical binding]; other site 869729008025 Q-loop/lid; other site 869729008026 ABC transporter signature motif; other site 869729008027 Walker B; other site 869729008028 D-loop; other site 869729008029 H-loop/switch region; other site 869729008030 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 869729008031 FtsX-like permease family; Region: FtsX; pfam02687 869729008032 macrolide transporter subunit MacA; Provisional; Region: PRK11578 869729008033 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 869729008034 HlyD family secretion protein; Region: HlyD_3; pfam13437 869729008035 Protein of unknown function (DUF535); Region: DUF535; pfam04393 869729008036 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 869729008037 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 869729008038 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 869729008039 putative active site [active] 869729008040 putative metal-binding site [ion binding]; other site 869729008041 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 869729008042 amphipathic channel; other site 869729008043 Asn-Pro-Ala signature motifs; other site 869729008044 Predicted membrane protein [Function unknown]; Region: COG2431 869729008045 hybrid cluster protein; Provisional; Region: PRK05290 869729008046 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 869729008047 ACS interaction site; other site 869729008048 CODH interaction site; other site 869729008049 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 869729008050 hybrid metal cluster; other site 869729008051 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 869729008052 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 869729008053 FAD binding pocket [chemical binding]; other site 869729008054 FAD binding motif [chemical binding]; other site 869729008055 phosphate binding motif [ion binding]; other site 869729008056 beta-alpha-beta structure motif; other site 869729008057 NAD binding pocket [chemical binding]; other site 869729008058 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 869729008059 catalytic loop [active] 869729008060 iron binding site [ion binding]; other site 869729008061 pyruvate dehydrogenase; Provisional; Region: PRK09124 869729008062 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 869729008063 PYR/PP interface [polypeptide binding]; other site 869729008064 dimer interface [polypeptide binding]; other site 869729008065 tetramer interface [polypeptide binding]; other site 869729008066 TPP binding site [chemical binding]; other site 869729008067 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 869729008068 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 869729008069 TPP-binding site [chemical binding]; other site 869729008070 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 869729008071 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 869729008072 tetramer interface [polypeptide binding]; other site 869729008073 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729008074 catalytic residue [active] 869729008075 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 869729008076 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 869729008077 putative NAD(P) binding site [chemical binding]; other site 869729008078 putative active site [active] 869729008079 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 869729008080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869729008081 NAD(P) binding site [chemical binding]; other site 869729008082 active site 869729008083 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 869729008084 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 869729008085 amidase catalytic site [active] 869729008086 Zn binding residues [ion binding]; other site 869729008087 substrate binding site [chemical binding]; other site 869729008088 hypothetical protein; Provisional; Region: PRK02877 869729008089 putative lipoprotein; Provisional; Region: PRK10533 869729008090 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 869729008091 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869729008092 Walker A/P-loop; other site 869729008093 ATP binding site [chemical binding]; other site 869729008094 Q-loop/lid; other site 869729008095 ABC transporter signature motif; other site 869729008096 Walker B; other site 869729008097 D-loop; other site 869729008098 H-loop/switch region; other site 869729008099 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869729008100 substrate binding pocket [chemical binding]; other site 869729008101 membrane-bound complex binding site; other site 869729008102 hinge residues; other site 869729008103 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 869729008104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729008105 dimer interface [polypeptide binding]; other site 869729008106 conserved gate region; other site 869729008107 putative PBP binding loops; other site 869729008108 ABC-ATPase subunit interface; other site 869729008109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729008110 dimer interface [polypeptide binding]; other site 869729008111 conserved gate region; other site 869729008112 putative PBP binding loops; other site 869729008113 ABC-ATPase subunit interface; other site 869729008114 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 869729008115 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869729008116 substrate binding pocket [chemical binding]; other site 869729008117 membrane-bound complex binding site; other site 869729008118 hinge residues; other site 869729008119 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 869729008120 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729008121 S-adenosylmethionine binding site [chemical binding]; other site 869729008122 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 869729008123 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 869729008124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729008125 dimer interface [polypeptide binding]; other site 869729008126 conserved gate region; other site 869729008127 putative PBP binding loops; other site 869729008128 ABC-ATPase subunit interface; other site 869729008129 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 869729008130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729008131 dimer interface [polypeptide binding]; other site 869729008132 conserved gate region; other site 869729008133 putative PBP binding loops; other site 869729008134 ABC-ATPase subunit interface; other site 869729008135 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 869729008136 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869729008137 Walker A/P-loop; other site 869729008138 ATP binding site [chemical binding]; other site 869729008139 Q-loop/lid; other site 869729008140 ABC transporter signature motif; other site 869729008141 Walker B; other site 869729008142 D-loop; other site 869729008143 H-loop/switch region; other site 869729008144 TOBE domain; Region: TOBE_2; pfam08402 869729008145 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 869729008146 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 869729008147 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 869729008148 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 869729008149 RimK-like ATP-grasp domain; Region: RimK; pfam08443 869729008150 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 869729008151 dimer interface [polypeptide binding]; other site 869729008152 FMN binding site [chemical binding]; other site 869729008153 NADPH bind site [chemical binding]; other site 869729008154 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 869729008155 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 869729008156 GSH binding site [chemical binding]; other site 869729008157 catalytic residues [active] 869729008158 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 869729008159 putative transporter; Provisional; Region: PRK04972 869729008160 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 869729008161 TrkA-C domain; Region: TrkA_C; pfam02080 869729008162 TrkA-C domain; Region: TrkA_C; pfam02080 869729008163 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 869729008164 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 869729008165 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869729008166 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 869729008167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729008168 putative substrate translocation pore; other site 869729008169 Major Facilitator Superfamily; Region: MFS_1; pfam07690 869729008170 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 869729008171 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869729008172 active site 869729008173 motif I; other site 869729008174 motif II; other site 869729008175 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869729008176 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 869729008177 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729008178 putative substrate translocation pore; other site 869729008179 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 869729008180 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 869729008181 active site 869729008182 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 869729008183 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 869729008184 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869729008185 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 869729008186 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 869729008187 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 869729008188 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 869729008189 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 869729008190 putative C-terminal domain interface [polypeptide binding]; other site 869729008191 putative GSH binding site (G-site) [chemical binding]; other site 869729008192 putative dimer interface [polypeptide binding]; other site 869729008193 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 869729008194 N-terminal domain interface [polypeptide binding]; other site 869729008195 dimer interface [polypeptide binding]; other site 869729008196 substrate binding pocket (H-site) [chemical binding]; other site 869729008197 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 869729008198 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 869729008199 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 869729008200 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 869729008201 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 869729008202 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869729008203 FeS/SAM binding site; other site 869729008204 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 869729008205 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 869729008206 metal binding site [ion binding]; metal-binding site 869729008207 active site 869729008208 I-site; other site 869729008209 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 869729008210 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 869729008211 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 869729008212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729008213 dimer interface [polypeptide binding]; other site 869729008214 conserved gate region; other site 869729008215 putative PBP binding loops; other site 869729008216 ABC-ATPase subunit interface; other site 869729008217 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 869729008218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729008219 dimer interface [polypeptide binding]; other site 869729008220 conserved gate region; other site 869729008221 putative PBP binding loops; other site 869729008222 ABC-ATPase subunit interface; other site 869729008223 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 869729008224 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 869729008225 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 869729008226 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869729008227 Walker A/P-loop; other site 869729008228 ATP binding site [chemical binding]; other site 869729008229 Q-loop/lid; other site 869729008230 ABC transporter signature motif; other site 869729008231 Walker B; other site 869729008232 D-loop; other site 869729008233 H-loop/switch region; other site 869729008234 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 869729008235 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869729008236 Walker A/P-loop; other site 869729008237 ATP binding site [chemical binding]; other site 869729008238 Q-loop/lid; other site 869729008239 ABC transporter signature motif; other site 869729008240 Walker B; other site 869729008241 D-loop; other site 869729008242 H-loop/switch region; other site 869729008243 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 869729008244 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 869729008245 catalytic nucleophile [active] 869729008246 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 869729008247 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 869729008248 dimer interface [polypeptide binding]; other site 869729008249 putative functional site; other site 869729008250 putative MPT binding site; other site 869729008251 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 869729008252 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 869729008253 ATP binding site [chemical binding]; other site 869729008254 substrate interface [chemical binding]; other site 869729008255 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 869729008256 active site 869729008257 intersubunit interactions; other site 869729008258 catalytic residue [active] 869729008259 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 869729008260 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 869729008261 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 869729008262 dimer interface [polypeptide binding]; other site 869729008263 active site 869729008264 glycine loop; other site 869729008265 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 869729008266 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869729008267 active site 869729008268 motif I; other site 869729008269 motif II; other site 869729008270 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869729008271 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 869729008272 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869729008273 Walker A/P-loop; other site 869729008274 ATP binding site [chemical binding]; other site 869729008275 Q-loop/lid; other site 869729008276 ABC transporter signature motif; other site 869729008277 Walker B; other site 869729008278 D-loop; other site 869729008279 H-loop/switch region; other site 869729008280 ABC transporter; Region: ABC_tran_2; pfam12848 869729008281 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869729008282 L,D-transpeptidase; Provisional; Region: PRK10260 869729008283 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 869729008284 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 869729008285 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 869729008286 transmembrane helices; other site 869729008287 manganese transport regulator MntR; Provisional; Region: PRK11050 869729008288 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 869729008289 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 869729008290 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 869729008291 Sulfatase; Region: Sulfatase; pfam00884 869729008292 outer membrane protein X; Provisional; Region: ompX; PRK09408 869729008293 threonine and homoserine efflux system; Provisional; Region: PRK10532 869729008294 EamA-like transporter family; Region: EamA; pfam00892 869729008295 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 869729008296 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 869729008297 dimerization interface [polypeptide binding]; other site 869729008298 DPS ferroxidase diiron center [ion binding]; other site 869729008299 ion pore; other site 869729008300 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 869729008301 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869729008302 substrate binding pocket [chemical binding]; other site 869729008303 membrane-bound complex binding site; other site 869729008304 hinge residues; other site 869729008305 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 869729008306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729008307 dimer interface [polypeptide binding]; other site 869729008308 conserved gate region; other site 869729008309 putative PBP binding loops; other site 869729008310 ABC-ATPase subunit interface; other site 869729008311 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 869729008312 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 869729008313 Walker A/P-loop; other site 869729008314 ATP binding site [chemical binding]; other site 869729008315 Q-loop/lid; other site 869729008316 ABC transporter signature motif; other site 869729008317 Walker B; other site 869729008318 D-loop; other site 869729008319 H-loop/switch region; other site 869729008320 putative mechanosensitive channel protein; Provisional; Region: PRK11465 869729008321 Mechanosensitive ion channel; Region: MS_channel; pfam00924 869729008322 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 869729008323 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 869729008324 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 869729008325 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 869729008326 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 869729008327 N-terminal plug; other site 869729008328 ligand-binding site [chemical binding]; other site 869729008329 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 869729008330 hypothetical protein; Provisional; Region: PRK11019 869729008331 hypothetical protein; Provisional; Region: PRK10259 869729008332 putative dehydrogenase; Provisional; Region: PRK10098 869729008333 glycosyl transferase family protein; Provisional; Region: PRK08136 869729008334 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 869729008335 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 869729008336 DEAD_2; Region: DEAD_2; pfam06733 869729008337 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 869729008338 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 869729008339 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 869729008340 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 869729008341 ATP binding site [chemical binding]; other site 869729008342 Mg++ binding site [ion binding]; other site 869729008343 motif III; other site 869729008344 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869729008345 nucleotide binding region [chemical binding]; other site 869729008346 ATP-binding site [chemical binding]; other site 869729008347 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 869729008348 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 869729008349 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 869729008350 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 869729008351 HlyD family secretion protein; Region: HlyD_3; pfam13437 869729008352 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 869729008353 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869729008354 Walker A/P-loop; other site 869729008355 ATP binding site [chemical binding]; other site 869729008356 Q-loop/lid; other site 869729008357 ABC transporter signature motif; other site 869729008358 Walker B; other site 869729008359 D-loop; other site 869729008360 H-loop/switch region; other site 869729008361 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 869729008362 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869729008363 Walker A/P-loop; other site 869729008364 ATP binding site [chemical binding]; other site 869729008365 Q-loop/lid; other site 869729008366 ABC transporter signature motif; other site 869729008367 Walker B; other site 869729008368 D-loop; other site 869729008369 H-loop/switch region; other site 869729008370 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 869729008371 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 869729008372 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 869729008373 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 869729008374 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 869729008375 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 869729008376 putative catalytic site [active] 869729008377 putative metal binding site [ion binding]; other site 869729008378 putative phosphate binding site [ion binding]; other site 869729008379 cardiolipin synthase 2; Provisional; Region: PRK11263 869729008380 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 869729008381 putative active site [active] 869729008382 catalytic site [active] 869729008383 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 869729008384 putative active site [active] 869729008385 catalytic site [active] 869729008386 Predicted integral membrane protein [Function unknown]; Region: COG0392 869729008387 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 869729008388 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 869729008389 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 869729008390 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 869729008391 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 869729008392 MoaE homodimer interface [polypeptide binding]; other site 869729008393 MoaD interaction [polypeptide binding]; other site 869729008394 active site residues [active] 869729008395 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 869729008396 MoaE interaction surface [polypeptide binding]; other site 869729008397 MoeB interaction surface [polypeptide binding]; other site 869729008398 thiocarboxylated glycine; other site 869729008399 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 869729008400 trimer interface [polypeptide binding]; other site 869729008401 dimer interface [polypeptide binding]; other site 869729008402 putative active site [active] 869729008403 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 869729008404 MPT binding site; other site 869729008405 trimer interface [polypeptide binding]; other site 869729008406 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 869729008407 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869729008408 FeS/SAM binding site; other site 869729008409 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 869729008410 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 869729008411 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 869729008412 putative substrate binding pocket [chemical binding]; other site 869729008413 dimer interface [polypeptide binding]; other site 869729008414 phosphate binding site [ion binding]; other site 869729008415 excinuclease ABC subunit B; Provisional; Region: PRK05298 869729008416 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869729008417 ATP binding site [chemical binding]; other site 869729008418 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869729008419 nucleotide binding region [chemical binding]; other site 869729008420 ATP-binding site [chemical binding]; other site 869729008421 Ultra-violet resistance protein B; Region: UvrB; pfam12344 869729008422 UvrB/uvrC motif; Region: UVR; pfam02151 869729008423 AAA domain; Region: AAA_26; pfam13500 869729008424 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 869729008425 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 869729008426 ADP binding site [chemical binding]; other site 869729008427 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 869729008428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729008429 S-adenosylmethionine binding site [chemical binding]; other site 869729008430 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 869729008431 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 869729008432 substrate-cofactor binding pocket; other site 869729008433 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729008434 catalytic residue [active] 869729008435 biotin synthase; Provisional; Region: PRK15108 869729008436 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869729008437 FeS/SAM binding site; other site 869729008438 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 869729008439 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 869729008440 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 869729008441 inhibitor-cofactor binding pocket; inhibition site 869729008442 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729008443 catalytic residue [active] 869729008444 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 869729008445 substrate binding site [chemical binding]; other site 869729008446 acyl-CoA thioesterase; Provisional; Region: PRK10531 869729008447 putative pectinesterase; Region: PLN02432; cl01911 869729008448 putative hydratase; Provisional; Region: PRK11413 869729008449 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 869729008450 substrate binding site [chemical binding]; other site 869729008451 ligand binding site [chemical binding]; other site 869729008452 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 869729008453 substrate binding site [chemical binding]; other site 869729008454 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 869729008455 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 869729008456 transmembrane helices; other site 869729008457 PrpF protein; Region: PrpF; pfam04303 869729008458 Transcriptional regulator [Transcription]; Region: LysR; COG0583 869729008459 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729008460 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 869729008461 putative dimerization interface [polypeptide binding]; other site 869729008462 6-phosphogluconolactonase; Provisional; Region: PRK11028 869729008463 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 869729008464 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869729008465 motif II; other site 869729008466 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869729008467 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 869729008468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869729008469 Walker A/P-loop; other site 869729008470 ATP binding site [chemical binding]; other site 869729008471 Q-loop/lid; other site 869729008472 ABC transporter signature motif; other site 869729008473 Walker B; other site 869729008474 D-loop; other site 869729008475 H-loop/switch region; other site 869729008476 molybdenum-pterin binding domain; Region: Mop; TIGR00638 869729008477 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 869729008478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729008479 dimer interface [polypeptide binding]; other site 869729008480 conserved gate region; other site 869729008481 putative PBP binding loops; other site 869729008482 ABC-ATPase subunit interface; other site 869729008483 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 869729008484 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869729008485 substrate binding pocket [chemical binding]; other site 869729008486 membrane-bound complex binding site; other site 869729008487 hinge residues; other site 869729008488 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 869729008489 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 869729008490 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 869729008491 molybdenum-pterin binding domain; Region: Mop; TIGR00638 869729008492 TOBE domain; Region: TOBE; pfam03459 869729008493 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 869729008494 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 869729008495 Walker A/P-loop; other site 869729008496 ATP binding site [chemical binding]; other site 869729008497 Q-loop/lid; other site 869729008498 ABC transporter signature motif; other site 869729008499 Walker B; other site 869729008500 D-loop; other site 869729008501 H-loop/switch region; other site 869729008502 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869729008503 Walker A/P-loop; other site 869729008504 ATP binding site [chemical binding]; other site 869729008505 Q-loop/lid; other site 869729008506 ABC transporter signature motif; other site 869729008507 Walker B; other site 869729008508 D-loop; other site 869729008509 H-loop/switch region; other site 869729008510 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 869729008511 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 869729008512 NAD binding site [chemical binding]; other site 869729008513 homodimer interface [polypeptide binding]; other site 869729008514 active site 869729008515 substrate binding site [chemical binding]; other site 869729008516 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 869729008517 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 869729008518 dimer interface [polypeptide binding]; other site 869729008519 active site 869729008520 galactokinase; Provisional; Region: PRK05101 869729008521 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 869729008522 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 869729008523 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 869729008524 active site 869729008525 catalytic residues [active] 869729008526 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869729008527 catalytic core [active] 869729008528 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869729008529 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 869729008530 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 869729008531 YbgS-like protein; Region: YbgS; pfam13985 869729008532 zinc transporter ZitB; Provisional; Region: PRK03557 869729008533 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 869729008534 quinolinate synthetase; Provisional; Region: PRK09375 869729008535 Tetratricopeptide repeat; Region: TPR_6; pfam13174 869729008536 tol-pal system protein YbgF; Provisional; Region: PRK10803 869729008537 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 869729008538 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 869729008539 ligand binding site [chemical binding]; other site 869729008540 translocation protein TolB; Provisional; Region: tolB; PRK03629 869729008541 TolB amino-terminal domain; Region: TolB_N; pfam04052 869729008542 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 869729008543 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 869729008544 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 869729008545 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 869729008546 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 869729008547 TolA C-terminal; Region: TolA; pfam06519 869729008548 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 869729008549 colicin uptake protein TolR; Provisional; Region: PRK11024 869729008550 colicin uptake protein TolQ; Provisional; Region: PRK10801 869729008551 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 869729008552 active site 869729008553 hypothetical protein; Provisional; Region: PRK10588 869729008554 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 869729008555 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 869729008556 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 869729008557 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 869729008558 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 869729008559 TPR repeat; Region: TPR_11; pfam13414 869729008560 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869729008561 binding surface 869729008562 TPR motif; other site 869729008563 Tetratricopeptide repeat; Region: TPR_12; pfam13424 869729008564 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 869729008565 CoA binding domain; Region: CoA_binding; smart00881 869729008566 CoA-ligase; Region: Ligase_CoA; pfam00549 869729008567 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 869729008568 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 869729008569 CoA-ligase; Region: Ligase_CoA; pfam00549 869729008570 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 869729008571 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 869729008572 E3 interaction surface; other site 869729008573 lipoyl attachment site [posttranslational modification]; other site 869729008574 e3 binding domain; Region: E3_binding; pfam02817 869729008575 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 869729008576 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 869729008577 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 869729008578 TPP-binding site [chemical binding]; other site 869729008579 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 869729008580 dimer interface [polypeptide binding]; other site 869729008581 PYR/PP interface [polypeptide binding]; other site 869729008582 TPP binding site [chemical binding]; other site 869729008583 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 869729008584 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 869729008585 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 869729008586 L-aspartate oxidase; Provisional; Region: PRK06175 869729008587 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 869729008588 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 869729008589 SdhC subunit interface [polypeptide binding]; other site 869729008590 proximal heme binding site [chemical binding]; other site 869729008591 cardiolipin binding site; other site 869729008592 Iron-sulfur protein interface; other site 869729008593 proximal quinone binding site [chemical binding]; other site 869729008594 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 869729008595 Iron-sulfur protein interface; other site 869729008596 proximal quinone binding site [chemical binding]; other site 869729008597 SdhD (CybS) interface [polypeptide binding]; other site 869729008598 proximal heme binding site [chemical binding]; other site 869729008599 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 869729008600 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 869729008601 dimer interface [polypeptide binding]; other site 869729008602 active site 869729008603 citrylCoA binding site [chemical binding]; other site 869729008604 NADH binding [chemical binding]; other site 869729008605 cationic pore residues; other site 869729008606 oxalacetate/citrate binding site [chemical binding]; other site 869729008607 coenzyme A binding site [chemical binding]; other site 869729008608 catalytic triad [active] 869729008609 Fimbrial protein; Region: Fimbrial; pfam00419 869729008610 Putative ammonia monooxygenase; Region: AmoA; pfam05145 869729008611 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 869729008612 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 869729008613 endonuclease VIII; Provisional; Region: PRK10445 869729008614 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 869729008615 DNA binding site [nucleotide binding] 869729008616 catalytic residue [active] 869729008617 putative catalytic residues [active] 869729008618 H2TH interface [polypeptide binding]; other site 869729008619 intercalation triad [nucleotide binding]; other site 869729008620 substrate specificity determining residue; other site 869729008621 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 869729008622 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 869729008623 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 869729008624 putative active site [active] 869729008625 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 869729008626 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 869729008627 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 869729008628 Uncharacterized conserved protein [Function unknown]; Region: COG0327 869729008629 metal-binding protein; Provisional; Region: PRK10799 869729008630 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 869729008631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729008632 putative substrate translocation pore; other site 869729008633 POT family; Region: PTR2; pfam00854 869729008634 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 869729008635 DNA photolyase; Region: DNA_photolyase; pfam00875 869729008636 hypothetical protein; Provisional; Region: PRK10167 869729008637 Uncharacterized conserved protein [Function unknown]; Region: COG3272 869729008638 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 869729008639 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 869729008640 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 869729008641 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 869729008642 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 869729008643 sensor protein KdpD; Provisional; Region: PRK10490 869729008644 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 869729008645 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 869729008646 Ligand Binding Site [chemical binding]; other site 869729008647 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 869729008648 GAF domain; Region: GAF_3; pfam13492 869729008649 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869729008650 dimer interface [polypeptide binding]; other site 869729008651 phosphorylation site [posttranslational modification] 869729008652 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729008653 ATP binding site [chemical binding]; other site 869729008654 Mg2+ binding site [ion binding]; other site 869729008655 G-X-G motif; other site 869729008656 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 869729008657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729008658 active site 869729008659 phosphorylation site [posttranslational modification] 869729008660 intermolecular recognition site; other site 869729008661 dimerization interface [polypeptide binding]; other site 869729008662 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869729008663 DNA binding site [nucleotide binding] 869729008664 ornithine decarboxylase; Provisional; Region: PRK13578 869729008665 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 869729008666 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 869729008667 homodimer interface [polypeptide binding]; other site 869729008668 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729008669 catalytic residue [active] 869729008670 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 869729008671 putrescine transporter; Provisional; Region: potE; PRK10655 869729008672 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 869729008673 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 869729008674 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 869729008675 active site 869729008676 substrate binding site [chemical binding]; other site 869729008677 metal binding site [ion binding]; metal-binding site 869729008678 replication initiation regulator SeqA; Provisional; Region: PRK11187 869729008679 acyl-CoA esterase; Provisional; Region: PRK10673 869729008680 PGAP1-like protein; Region: PGAP1; pfam07819 869729008681 LexA regulated protein; Provisional; Region: PRK11675 869729008682 flavodoxin FldA; Validated; Region: PRK09267 869729008683 ferric uptake regulator; Provisional; Region: fur; PRK09462 869729008684 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 869729008685 metal binding site 2 [ion binding]; metal-binding site 869729008686 putative DNA binding helix; other site 869729008687 metal binding site 1 [ion binding]; metal-binding site 869729008688 dimer interface [polypeptide binding]; other site 869729008689 structural Zn2+ binding site [ion binding]; other site 869729008690 YbfN-like lipoprotein; Region: YbfN; pfam13982 869729008691 outer membrane porin, OprD family; Region: OprD; pfam03573 869729008692 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 869729008693 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 869729008694 active site 869729008695 HIGH motif; other site 869729008696 nucleotide binding site [chemical binding]; other site 869729008697 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 869729008698 KMSKS motif; other site 869729008699 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 869729008700 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 869729008701 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 869729008702 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869729008703 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 869729008704 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 869729008705 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 869729008706 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 869729008707 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 869729008708 putative active site [active] 869729008709 metal binding site [ion binding]; metal-binding site 869729008710 dihydrodipicolinate synthase; Region: dapA; TIGR00674 869729008711 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 869729008712 inhibitor site; inhibition site 869729008713 active site 869729008714 dimer interface [polypeptide binding]; other site 869729008715 catalytic residue [active] 869729008716 potential frameshift: common BLAST hit: gi|110640893|ref|YP_668621.1| putative integral membrane transport protein 869729008717 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 869729008718 BNR repeat-like domain; Region: BNR_2; pfam13088 869729008719 Domain of unknown function (DUF386); Region: DUF386; cl01047 869729008720 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 869729008721 transmembrane helices; other site 869729008722 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 869729008723 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 869729008724 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869729008725 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869729008726 active site turn [active] 869729008727 phosphorylation site [posttranslational modification] 869729008728 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 869729008729 HPr interaction site; other site 869729008730 glycerol kinase (GK) interaction site [polypeptide binding]; other site 869729008731 active site 869729008732 phosphorylation site [posttranslational modification] 869729008733 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 869729008734 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 869729008735 active site 869729008736 trimer interface [polypeptide binding]; other site 869729008737 allosteric site; other site 869729008738 active site lid [active] 869729008739 hexamer (dimer of trimers) interface [polypeptide binding]; other site 869729008740 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 869729008741 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 869729008742 active site 869729008743 dimer interface [polypeptide binding]; other site 869729008744 MarR family; Region: MarR; pfam01047 869729008745 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 869729008746 ROK family; Region: ROK; pfam00480 869729008747 UMP phosphatase; Provisional; Region: PRK10444 869729008748 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869729008749 active site 869729008750 motif I; other site 869729008751 motif II; other site 869729008752 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869729008753 asparagine synthetase B; Provisional; Region: asnB; PRK09431 869729008754 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 869729008755 active site 869729008756 dimer interface [polypeptide binding]; other site 869729008757 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 869729008758 Ligand Binding Site [chemical binding]; other site 869729008759 Molecular Tunnel; other site 869729008760 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 869729008761 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 869729008762 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 869729008763 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 869729008764 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869729008765 FeS/SAM binding site; other site 869729008766 TRAM domain; Region: TRAM; pfam01938 869729008767 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 869729008768 PhoH-like protein; Region: PhoH; pfam02562 869729008769 metal-binding heat shock protein; Provisional; Region: PRK00016 869729008770 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 869729008771 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 869729008772 Transporter associated domain; Region: CorC_HlyC; smart01091 869729008773 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 869729008774 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 869729008775 putative active site [active] 869729008776 catalytic triad [active] 869729008777 putative dimer interface [polypeptide binding]; other site 869729008778 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 869729008779 Uncharacterized conserved protein [Function unknown]; Region: COG3391 869729008780 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 869729008781 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 869729008782 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 869729008783 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869729008784 substrate binding pocket [chemical binding]; other site 869729008785 membrane-bound complex binding site; other site 869729008786 hinge residues; other site 869729008787 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 869729008788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729008789 dimer interface [polypeptide binding]; other site 869729008790 conserved gate region; other site 869729008791 putative PBP binding loops; other site 869729008792 ABC-ATPase subunit interface; other site 869729008793 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 869729008794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729008795 dimer interface [polypeptide binding]; other site 869729008796 conserved gate region; other site 869729008797 putative PBP binding loops; other site 869729008798 ABC-ATPase subunit interface; other site 869729008799 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 869729008800 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 869729008801 Walker A/P-loop; other site 869729008802 ATP binding site [chemical binding]; other site 869729008803 Q-loop/lid; other site 869729008804 ABC transporter signature motif; other site 869729008805 Walker B; other site 869729008806 D-loop; other site 869729008807 H-loop/switch region; other site 869729008808 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 869729008809 active site 869729008810 tetramer interface [polypeptide binding]; other site 869729008811 hypothetical protein; Provisional; Region: PRK11032 869729008812 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 869729008813 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 869729008814 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 869729008815 HIGH motif; other site 869729008816 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 869729008817 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 869729008818 active site 869729008819 KMSKS motif; other site 869729008820 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 869729008821 tRNA binding surface [nucleotide binding]; other site 869729008822 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 869729008823 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 869729008824 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 869729008825 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 869729008826 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 869729008827 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 869729008828 active site 869729008829 (T/H)XGH motif; other site 869729008830 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869729008831 catalytic core [active] 869729008832 ribosome-associated protein; Provisional; Region: PRK11538 869729008833 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 869729008834 penicillin-binding protein 2; Provisional; Region: PRK10795 869729008835 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 869729008836 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 869729008837 cell wall shape-determining protein; Provisional; Region: PRK10794 869729008838 rare lipoprotein A; Provisional; Region: PRK10672 869729008839 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 869729008840 Sporulation related domain; Region: SPOR; pfam05036 869729008841 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 869729008842 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 869729008843 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 869729008844 hypothetical protein; Provisional; Region: PRK04998 869729008845 lipoate-protein ligase B; Provisional; Region: PRK14342 869729008846 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 869729008847 lipoyl synthase; Provisional; Region: PRK05481 869729008848 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869729008849 FeS/SAM binding site; other site 869729008850 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 869729008851 Predicted amidohydrolase [General function prediction only]; Region: COG0388 869729008852 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 869729008853 putative active site [active] 869729008854 catalytic triad [active] 869729008855 putative dimer interface [polypeptide binding]; other site 869729008856 chromosome condensation membrane protein; Provisional; Region: PRK14196 869729008857 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 869729008858 DNA-binding site [nucleotide binding]; DNA binding site 869729008859 RNA-binding motif; other site 869729008860 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 869729008861 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 869729008862 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 869729008863 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 869729008864 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729008865 active site 869729008866 phosphorylation site [posttranslational modification] 869729008867 intermolecular recognition site; other site 869729008868 dimerization interface [polypeptide binding]; other site 869729008869 Transcriptional regulator; Region: CitT; pfam12431 869729008870 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 869729008871 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869729008872 putative active site [active] 869729008873 heme pocket [chemical binding]; other site 869729008874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729008875 ATP binding site [chemical binding]; other site 869729008876 Mg2+ binding site [ion binding]; other site 869729008877 G-X-G motif; other site 869729008878 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 869729008879 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 869729008880 putative active site [active] 869729008881 (T/H)XGH motif; other site 869729008882 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 869729008883 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 869729008884 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 869729008885 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 869729008886 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 869729008887 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 869729008888 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 869729008889 transmembrane helices; other site 869729008890 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 869729008891 B1 nucleotide binding pocket [chemical binding]; other site 869729008892 B2 nucleotide binding pocket [chemical binding]; other site 869729008893 CAS motifs; other site 869729008894 active site 869729008895 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 869729008896 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 869729008897 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 869729008898 Ligand Binding Site [chemical binding]; other site 869729008899 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 869729008900 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 869729008901 catalytic residue [active] 869729008902 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 869729008903 catalytic residues [active] 869729008904 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869729008905 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869729008906 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 869729008907 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 869729008908 dimer interface [polypeptide binding]; other site 869729008909 decamer (pentamer of dimers) interface [polypeptide binding]; other site 869729008910 catalytic triad [active] 869729008911 peroxidatic and resolving cysteines [active] 869729008912 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 869729008913 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 869729008914 dimerization domain [polypeptide binding]; other site 869729008915 dimer interface [polypeptide binding]; other site 869729008916 catalytic residues [active] 869729008917 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 869729008918 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729008919 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 869729008920 dimerization interface [polypeptide binding]; other site 869729008921 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 869729008922 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 869729008923 Active Sites [active] 869729008924 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 869729008925 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 869729008926 ParB-like nuclease domain; Region: ParBc; pfam02195 869729008927 methionine aminotransferase; Validated; Region: PRK09082 869729008928 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869729008929 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729008930 homodimer interface [polypeptide binding]; other site 869729008931 catalytic residue [active] 869729008932 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 869729008933 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 869729008934 putative active site [active] 869729008935 metal binding site [ion binding]; metal-binding site 869729008936 Uncharacterized small protein [Function unknown]; Region: COG2879 869729008937 carbon starvation protein A; Provisional; Region: PRK15015 869729008938 Carbon starvation protein CstA; Region: CstA; pfam02554 869729008939 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 869729008940 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 869729008941 CoenzymeA binding site [chemical binding]; other site 869729008942 subunit interaction site [polypeptide binding]; other site 869729008943 PHB binding site; other site 869729008944 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 869729008945 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 869729008946 putative NAD(P) binding site [chemical binding]; other site 869729008947 active site 869729008948 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 869729008949 hydrophobic substrate binding pocket; other site 869729008950 Isochorismatase family; Region: Isochorismatase; pfam00857 869729008951 active site 869729008952 conserved cis-peptide bond; other site 869729008953 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 869729008954 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 869729008955 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 869729008956 acyl-activating enzyme (AAE) consensus motif; other site 869729008957 active site 869729008958 AMP binding site [chemical binding]; other site 869729008959 substrate binding site [chemical binding]; other site 869729008960 isochorismate synthase EntC; Provisional; Region: PRK15016 869729008961 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 869729008962 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 869729008963 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 869729008964 siderophore binding site; other site 869729008965 enterobactin exporter EntS; Provisional; Region: PRK10489 869729008966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729008967 putative substrate translocation pore; other site 869729008968 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 869729008969 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869729008970 ABC-ATPase subunit interface; other site 869729008971 dimer interface [polypeptide binding]; other site 869729008972 putative PBP binding regions; other site 869729008973 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 869729008974 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869729008975 ABC-ATPase subunit interface; other site 869729008976 dimer interface [polypeptide binding]; other site 869729008977 putative PBP binding regions; other site 869729008978 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 869729008979 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 869729008980 Walker A/P-loop; other site 869729008981 ATP binding site [chemical binding]; other site 869729008982 Q-loop/lid; other site 869729008983 ABC transporter signature motif; other site 869729008984 Walker B; other site 869729008985 D-loop; other site 869729008986 H-loop/switch region; other site 869729008987 LPS O-antigen length regulator; Provisional; Region: PRK10381 869729008988 Chain length determinant protein; Region: Wzz; pfam02706 869729008989 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 869729008990 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 869729008991 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 869729008992 acyl-activating enzyme (AAE) consensus motif; other site 869729008993 AMP binding site [chemical binding]; other site 869729008994 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 869729008995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 869729008996 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 869729008997 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 869729008998 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 869729008999 outer membrane receptor FepA; Provisional; Region: PRK13524 869729009000 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 869729009001 N-terminal plug; other site 869729009002 ligand-binding site [chemical binding]; other site 869729009003 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 869729009004 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 869729009005 Hok/gef family; Region: HOK_GEF; pfam01848 869729009006 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 869729009007 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 869729009008 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 869729009009 hypothetical protein; Provisional; Region: PRK10250 869729009010 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 869729009011 dimer interface [polypeptide binding]; other site 869729009012 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 869729009013 Mechanosensitive ion channel; Region: MS_channel; pfam00924 869729009014 phenylalanine transporter; Provisional; Region: PRK10249 869729009015 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 869729009016 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 869729009017 HlyD family secretion protein; Region: HlyD_3; pfam13437 869729009018 periplasmic copper-binding protein; Provisional; Region: PRK09838 869729009019 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 869729009020 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 869729009021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729009022 active site 869729009023 phosphorylation site [posttranslational modification] 869729009024 intermolecular recognition site; other site 869729009025 dimerization interface [polypeptide binding]; other site 869729009026 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869729009027 DNA binding site [nucleotide binding] 869729009028 sensor kinase CusS; Provisional; Region: PRK09835 869729009029 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869729009030 dimerization interface [polypeptide binding]; other site 869729009031 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869729009032 dimer interface [polypeptide binding]; other site 869729009033 phosphorylation site [posttranslational modification] 869729009034 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729009035 ATP binding site [chemical binding]; other site 869729009036 Mg2+ binding site [ion binding]; other site 869729009037 G-X-G motif; other site 869729009038 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 869729009039 active site 869729009040 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 869729009041 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 869729009042 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 869729009043 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869729009044 TPR motif; other site 869729009045 binding surface 869729009046 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 869729009047 hypothetical protein; Provisional; Region: PRK09936 869729009048 outer membrane protease; Reviewed; Region: PRK10993 869729009049 Methyltransferase domain; Region: Methyltransf_12; pfam08242 869729009050 S-adenosylmethionine binding site [chemical binding]; other site 869729009051 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 869729009052 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 869729009053 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 869729009054 DNA binding site [nucleotide binding] 869729009055 active site 869729009056 Int/Topo IB signature motif; other site 869729009057 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 869729009058 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 869729009059 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 869729009060 homodimer interface [polypeptide binding]; other site 869729009061 NADP binding site [chemical binding]; other site 869729009062 substrate binding site [chemical binding]; other site 869729009063 ribosome-associated protein; Provisional; Region: PRK11507 869729009064 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 869729009065 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 869729009066 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 869729009067 active site 869729009068 HIGH motif; other site 869729009069 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 869729009070 KMSKS motif; other site 869729009071 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 869729009072 tRNA binding surface [nucleotide binding]; other site 869729009073 anticodon binding site; other site 869729009074 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 869729009075 substrate binding site [chemical binding]; other site 869729009076 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 869729009077 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 869729009078 putative active site [active] 869729009079 putative metal binding site [ion binding]; other site 869729009080 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 869729009081 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 869729009082 ATP-grasp domain; Region: ATP-grasp; pfam02222 869729009083 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 869729009084 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 869729009085 putative substrate binding site [chemical binding]; other site 869729009086 nucleotide binding site [chemical binding]; other site 869729009087 nucleotide binding site [chemical binding]; other site 869729009088 homodimer interface [polypeptide binding]; other site 869729009089 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 869729009090 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 869729009091 membrane protein FdrA; Validated; Region: PRK06091 869729009092 CoA binding domain; Region: CoA_binding; pfam02629 869729009093 CoA-ligase; Region: Ligase_CoA; pfam00549 869729009094 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 869729009095 allantoate amidohydrolase; Region: AllC; TIGR03176 869729009096 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 869729009097 active site 869729009098 metal binding site [ion binding]; metal-binding site 869729009099 dimer interface [polypeptide binding]; other site 869729009100 putative allantoin catabolism protein; Region: ura-cupin; TIGR03214 869729009101 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 869729009102 Cupin domain; Region: Cupin_2; cl17218 869729009103 glycerate kinase II; Provisional; Region: PRK09932 869729009104 putative uracil/xanthine transporter; Provisional; Region: PRK11412 869729009105 allantoinase; Provisional; Region: PRK08044 869729009106 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 869729009107 active site 869729009108 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 869729009109 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 869729009110 Na binding site [ion binding]; other site 869729009111 substrate binding site [chemical binding]; other site 869729009112 tartronate semialdehyde reductase; Provisional; Region: PRK15059 869729009113 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 869729009114 hydroxypyruvate isomerase; Provisional; Region: PRK09997 869729009115 glyoxylate carboligase; Provisional; Region: PRK11269 869729009116 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 869729009117 PYR/PP interface [polypeptide binding]; other site 869729009118 dimer interface [polypeptide binding]; other site 869729009119 TPP binding site [chemical binding]; other site 869729009120 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 869729009121 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 869729009122 TPP-binding site [chemical binding]; other site 869729009123 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 869729009124 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 869729009125 Bacterial transcriptional regulator; Region: IclR; pfam01614 869729009126 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 869729009127 ureidoglycolate hydrolase; Provisional; Region: PRK03606 869729009128 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 869729009129 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729009130 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 869729009131 dimerization interface [polypeptide binding]; other site 869729009132 Predicted ATPase [General function prediction only]; Region: COG2603 869729009133 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 869729009134 active site residue [active] 869729009135 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 869729009136 FtsX-like permease family; Region: FtsX; pfam02687 869729009137 FtsX-like permease family; Region: FtsX; pfam02687 869729009138 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 869729009139 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869729009140 Walker A/P-loop; other site 869729009141 ATP binding site [chemical binding]; other site 869729009142 Q-loop/lid; other site 869729009143 ABC transporter signature motif; other site 869729009144 Walker B; other site 869729009145 D-loop; other site 869729009146 H-loop/switch region; other site 869729009147 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 869729009148 active site 869729009149 catalytic triad [active] 869729009150 oxyanion hole [active] 869729009151 switch loop; other site 869729009152 oxidoreductase; Provisional; Region: PRK08017 869729009153 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 869729009154 NADP binding site [chemical binding]; other site 869729009155 active site 869729009156 steroid binding site; other site 869729009157 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 869729009158 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 869729009159 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 869729009160 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 869729009161 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869729009162 Walker A/P-loop; other site 869729009163 ATP binding site [chemical binding]; other site 869729009164 Q-loop/lid; other site 869729009165 ABC transporter signature motif; other site 869729009166 Walker B; other site 869729009167 D-loop; other site 869729009168 H-loop/switch region; other site 869729009169 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 869729009170 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 869729009171 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 869729009172 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 869729009173 YadA-like C-terminal region; Region: YadA; pfam03895 869729009174 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 869729009175 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 869729009176 DNA binding residues [nucleotide binding] 869729009177 dimer interface [polypeptide binding]; other site 869729009178 copper binding site [ion binding]; other site 869729009179 amino acid transporter; Region: 2A0306; TIGR00909 869729009180 glutaminase; Reviewed; Region: PRK12356 869729009181 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 869729009182 copper exporting ATPase; Provisional; Region: copA; PRK10671 869729009183 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 869729009184 metal-binding site [ion binding] 869729009185 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 869729009186 metal-binding site [ion binding] 869729009187 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 869729009188 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869729009189 motif II; other site 869729009190 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 869729009191 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869729009192 non-specific DNA binding site [nucleotide binding]; other site 869729009193 salt bridge; other site 869729009194 sequence-specific DNA binding site [nucleotide binding]; other site 869729009195 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 869729009196 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 869729009197 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 869729009198 putative deacylase active site [active] 869729009199 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 869729009200 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 869729009201 active site 869729009202 metal binding site [ion binding]; metal-binding site 869729009203 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 869729009204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729009205 Major Facilitator Superfamily; Region: MFS_1; pfam07690 869729009206 putative substrate translocation pore; other site 869729009207 putative cation:proton antiport protein; Provisional; Region: PRK10669 869729009208 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 869729009209 TrkA-N domain; Region: TrkA_N; pfam02254 869729009210 inosine/guanosine kinase; Provisional; Region: PRK15074 869729009211 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 869729009212 acetyl esterase; Provisional; Region: PRK10162 869729009213 ferrochelatase; Region: hemH; TIGR00109 869729009214 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 869729009215 C-terminal domain interface [polypeptide binding]; other site 869729009216 active site 869729009217 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 869729009218 active site 869729009219 N-terminal domain interface [polypeptide binding]; other site 869729009220 adenylate kinase; Reviewed; Region: adk; PRK00279 869729009221 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 869729009222 AMP-binding site [chemical binding]; other site 869729009223 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 869729009224 heat shock protein 90; Provisional; Region: PRK05218 869729009225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729009226 ATP binding site [chemical binding]; other site 869729009227 Mg2+ binding site [ion binding]; other site 869729009228 G-X-G motif; other site 869729009229 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 869729009230 RecR protein; Region: RecR; pfam02132 869729009231 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 869729009232 putative active site [active] 869729009233 putative metal-binding site [ion binding]; other site 869729009234 tetramer interface [polypeptide binding]; other site 869729009235 hypothetical protein; Validated; Region: PRK00153 869729009236 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 869729009237 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729009238 Walker A motif; other site 869729009239 ATP binding site [chemical binding]; other site 869729009240 Walker B motif; other site 869729009241 DNA polymerase III subunit delta'; Validated; Region: PRK08485 869729009242 arginine finger; other site 869729009243 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 869729009244 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 869729009245 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 869729009246 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869729009247 active site 869729009248 hypothetical protein; Provisional; Region: PRK10527 869729009249 primosomal replication protein N''; Provisional; Region: PRK10093 869729009250 hypothetical protein; Provisional; Region: PRK11038 869729009251 hypothetical protein; Provisional; Region: PRK11281 869729009252 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 869729009253 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 869729009254 Mechanosensitive ion channel; Region: MS_channel; pfam00924 869729009255 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 869729009256 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869729009257 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 869729009258 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 869729009259 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 869729009260 HlyD family secretion protein; Region: HlyD_3; pfam13437 869729009261 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 869729009262 Protein export membrane protein; Region: SecD_SecF; cl14618 869729009263 Protein export membrane protein; Region: SecD_SecF; cl14618 869729009264 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 869729009265 gene expression modulator; Provisional; Region: PRK10945 869729009266 maltose O-acetyltransferase; Provisional; Region: PRK10092 869729009267 Maltose acetyltransferase; Region: Mac; pfam12464 869729009268 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 869729009269 trimer interface [polypeptide binding]; other site 869729009270 active site 869729009271 substrate binding site [chemical binding]; other site 869729009272 CoA binding site [chemical binding]; other site 869729009273 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 869729009274 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 869729009275 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 869729009276 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 869729009277 Uncharacterized conserved protein [Function unknown]; Region: COG5507 869729009278 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 869729009279 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 869729009280 DNA binding site [nucleotide binding] 869729009281 active site 869729009282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 869729009283 acyl-CoA thioesterase II; Provisional; Region: PRK10526 869729009284 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 869729009285 active site 869729009286 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 869729009287 catalytic triad [active] 869729009288 dimer interface [polypeptide binding]; other site 869729009289 ammonium transporter; Provisional; Region: PRK10666 869729009290 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 869729009291 Nitrogen regulatory protein P-II; Region: P-II; smart00938 869729009292 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 869729009293 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869729009294 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 869729009295 Walker A/P-loop; other site 869729009296 ATP binding site [chemical binding]; other site 869729009297 Q-loop/lid; other site 869729009298 ABC transporter signature motif; other site 869729009299 Walker B; other site 869729009300 D-loop; other site 869729009301 H-loop/switch region; other site 869729009302 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869729009303 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 869729009304 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869729009305 Walker A/P-loop; other site 869729009306 ATP binding site [chemical binding]; other site 869729009307 Q-loop/lid; other site 869729009308 ABC transporter signature motif; other site 869729009309 Walker B; other site 869729009310 D-loop; other site 869729009311 H-loop/switch region; other site 869729009312 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 869729009313 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869729009314 putative DNA binding site [nucleotide binding]; other site 869729009315 putative Zn2+ binding site [ion binding]; other site 869729009316 AsnC family; Region: AsnC_trans_reg; pfam01037 869729009317 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 869729009318 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869729009319 active site 869729009320 motif I; other site 869729009321 motif II; other site 869729009322 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 869729009323 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 869729009324 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 869729009325 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 869729009326 Ligand Binding Site [chemical binding]; other site 869729009327 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 869729009328 active site 869729009329 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 869729009330 periplasmic folding chaperone; Provisional; Region: PRK10788 869729009331 SurA N-terminal domain; Region: SurA_N_3; cl07813 869729009332 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 869729009333 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 869729009334 IHF dimer interface [polypeptide binding]; other site 869729009335 IHF - DNA interface [nucleotide binding]; other site 869729009336 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 869729009337 Found in ATP-dependent protease La (LON); Region: LON; smart00464 869729009338 Found in ATP-dependent protease La (LON); Region: LON; smart00464 869729009339 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729009340 Walker A motif; other site 869729009341 ATP binding site [chemical binding]; other site 869729009342 Walker B motif; other site 869729009343 arginine finger; other site 869729009344 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 869729009345 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 869729009346 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 869729009347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729009348 Walker A motif; other site 869729009349 ATP binding site [chemical binding]; other site 869729009350 Walker B motif; other site 869729009351 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 869729009352 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 869729009353 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 869729009354 oligomer interface [polypeptide binding]; other site 869729009355 active site residues [active] 869729009356 trigger factor; Provisional; Region: tig; PRK01490 869729009357 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 869729009358 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 869729009359 transcriptional regulator BolA; Provisional; Region: PRK11628 869729009360 hypothetical protein; Provisional; Region: PRK11627 869729009361 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 869729009362 muropeptide transporter; Reviewed; Region: ampG; PRK11902 869729009363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729009364 putative substrate translocation pore; other site 869729009365 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 869729009366 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 869729009367 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 869729009368 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 869729009369 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 869729009370 D-pathway; other site 869729009371 Putative ubiquinol binding site [chemical binding]; other site 869729009372 Low-spin heme (heme b) binding site [chemical binding]; other site 869729009373 Putative water exit pathway; other site 869729009374 Binuclear center (heme o3/CuB) [ion binding]; other site 869729009375 K-pathway; other site 869729009376 Putative proton exit pathway; other site 869729009377 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 869729009378 Subunit III/IV interface [polypeptide binding]; other site 869729009379 Subunit I/III interface [polypeptide binding]; other site 869729009380 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 869729009381 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 869729009382 UbiA prenyltransferase family; Region: UbiA; pfam01040 869729009383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729009384 Major Facilitator Superfamily; Region: MFS_1; pfam07690 869729009385 putative substrate translocation pore; other site 869729009386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 869729009387 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 869729009388 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 869729009389 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 869729009390 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 869729009391 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 869729009392 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 869729009393 conserved cys residue [active] 869729009394 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 869729009395 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 869729009396 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 869729009397 Ligand Binding Site [chemical binding]; other site 869729009398 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 869729009399 active site residue [active] 869729009400 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 869729009401 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 869729009402 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 869729009403 substrate binding pocket [chemical binding]; other site 869729009404 chain length determination region; other site 869729009405 substrate-Mg2+ binding site; other site 869729009406 catalytic residues [active] 869729009407 aspartate-rich region 1; other site 869729009408 active site lid residues [active] 869729009409 aspartate-rich region 2; other site 869729009410 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 869729009411 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 869729009412 TPP-binding site; other site 869729009413 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 869729009414 PYR/PP interface [polypeptide binding]; other site 869729009415 dimer interface [polypeptide binding]; other site 869729009416 TPP binding site [chemical binding]; other site 869729009417 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869729009418 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 869729009419 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 869729009420 active site 869729009421 catalytic tetrad [active] 869729009422 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 869729009423 tetramer interfaces [polypeptide binding]; other site 869729009424 binuclear metal-binding site [ion binding]; other site 869729009425 thiamine monophosphate kinase; Provisional; Region: PRK05731 869729009426 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 869729009427 ATP binding site [chemical binding]; other site 869729009428 dimerization interface [polypeptide binding]; other site 869729009429 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 869729009430 putative RNA binding site [nucleotide binding]; other site 869729009431 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 869729009432 homopentamer interface [polypeptide binding]; other site 869729009433 active site 869729009434 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 869729009435 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 869729009436 catalytic motif [active] 869729009437 Zn binding site [ion binding]; other site 869729009438 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 869729009439 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 869729009440 ATP cone domain; Region: ATP-cone; pfam03477 869729009441 hypothetical protein; Provisional; Region: PRK11530 869729009442 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 869729009443 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 869729009444 active site 869729009445 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 869729009446 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 869729009447 Protein export membrane protein; Region: SecD_SecF; pfam02355 869729009448 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 869729009449 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 869729009450 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 869729009451 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 869729009452 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 869729009453 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 869729009454 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 869729009455 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 869729009456 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 869729009457 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 869729009458 maltodextrin glucosidase; Provisional; Region: PRK10785 869729009459 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 869729009460 homodimer interface [polypeptide binding]; other site 869729009461 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 869729009462 active site 869729009463 homodimer interface [polypeptide binding]; other site 869729009464 catalytic site [active] 869729009465 putative proline-specific permease; Provisional; Region: proY; PRK10580 869729009466 Spore germination protein; Region: Spore_permease; cl17796 869729009467 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 869729009468 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 869729009469 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 869729009470 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869729009471 putative active site [active] 869729009472 heme pocket [chemical binding]; other site 869729009473 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869729009474 dimer interface [polypeptide binding]; other site 869729009475 phosphorylation site [posttranslational modification] 869729009476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729009477 ATP binding site [chemical binding]; other site 869729009478 Mg2+ binding site [ion binding]; other site 869729009479 G-X-G motif; other site 869729009480 transcriptional regulator PhoB; Provisional; Region: PRK10161 869729009481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729009482 active site 869729009483 phosphorylation site [posttranslational modification] 869729009484 intermolecular recognition site; other site 869729009485 dimerization interface [polypeptide binding]; other site 869729009486 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869729009487 DNA binding site [nucleotide binding] 869729009488 exonuclease subunit SbcD; Provisional; Region: PRK10966 869729009489 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 869729009490 active site 869729009491 metal binding site [ion binding]; metal-binding site 869729009492 DNA binding site [nucleotide binding] 869729009493 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 869729009494 exonuclease subunit SbcC; Provisional; Region: PRK10246 869729009495 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869729009496 Walker A/P-loop; other site 869729009497 ATP binding site [chemical binding]; other site 869729009498 Q-loop/lid; other site 869729009499 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869729009500 ABC transporter signature motif; other site 869729009501 Walker B; other site 869729009502 D-loop; other site 869729009503 H-loop/switch region; other site 869729009504 MFS transport protein AraJ; Provisional; Region: PRK10091 869729009505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729009506 putative substrate translocation pore; other site 869729009507 fructokinase; Reviewed; Region: PRK09557 869729009508 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 869729009509 nucleotide binding site [chemical binding]; other site 869729009510 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 869729009511 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 869729009512 hypothetical protein; Provisional; Region: PRK10579 869729009513 hypothetical protein; Provisional; Region: PRK10481 869729009514 hypothetical protein; Provisional; Region: PRK10380 869729009515 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 869729009516 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 869729009517 ADP binding site [chemical binding]; other site 869729009518 magnesium binding site [ion binding]; other site 869729009519 putative shikimate binding site; other site 869729009520 hypothetical protein; Validated; Region: PRK00124 869729009521 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 869729009522 pyrroline-5-carboxylate reductase; Region: PLN02688 869729009523 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 869729009524 MASE2 domain; Region: MASE2; pfam05230 869729009525 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 869729009526 metal binding site [ion binding]; metal-binding site 869729009527 active site 869729009528 I-site; other site 869729009529 hypothetical protein; Provisional; Region: PRK11505 869729009530 psiF repeat; Region: PsiF_repeat; pfam07769 869729009531 psiF repeat; Region: PsiF_repeat; pfam07769 869729009532 alkaline phosphatase; Provisional; Region: PRK10518 869729009533 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 869729009534 dimer interface [polypeptide binding]; other site 869729009535 active site 869729009536 anti-RssB factor; Provisional; Region: PRK10244 869729009537 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 869729009538 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 869729009539 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 869729009540 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 869729009541 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 869729009542 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 869729009543 microcin B17 transporter; Reviewed; Region: PRK11098 869729009544 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 869729009545 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 869729009546 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 869729009547 potential frameshift: common BLAST hit: gi|218557283|ref|YP_002390196.1| putative flagellin-like structural protein 869729009548 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 869729009549 dimer interface [polypeptide binding]; other site 869729009550 active site 869729009551 Schiff base residues; other site 869729009552 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 869729009553 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 869729009554 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 869729009555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729009556 dimer interface [polypeptide binding]; other site 869729009557 conserved gate region; other site 869729009558 putative PBP binding loops; other site 869729009559 ABC-ATPase subunit interface; other site 869729009560 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 869729009561 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 869729009562 Walker A/P-loop; other site 869729009563 ATP binding site [chemical binding]; other site 869729009564 Q-loop/lid; other site 869729009565 ABC transporter signature motif; other site 869729009566 Walker B; other site 869729009567 D-loop; other site 869729009568 H-loop/switch region; other site 869729009569 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 869729009570 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869729009571 substrate binding pocket [chemical binding]; other site 869729009572 membrane-bound complex binding site; other site 869729009573 hinge residues; other site 869729009574 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 869729009575 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 869729009576 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 869729009577 DXD motif; other site 869729009578 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 869729009579 putative trimer interface [polypeptide binding]; other site 869729009580 putative CoA binding site [chemical binding]; other site 869729009581 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 869729009582 putative metal binding site [ion binding]; other site 869729009583 putative homodimer interface [polypeptide binding]; other site 869729009584 putative homotetramer interface [polypeptide binding]; other site 869729009585 putative homodimer-homodimer interface [polypeptide binding]; other site 869729009586 putative allosteric switch controlling residues; other site 869729009587 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 869729009588 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 869729009589 substrate binding site [chemical binding]; other site 869729009590 catalytic Zn binding site [ion binding]; other site 869729009591 NAD binding site [chemical binding]; other site 869729009592 structural Zn binding site [ion binding]; other site 869729009593 dimer interface [polypeptide binding]; other site 869729009594 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 869729009595 S-formylglutathione hydrolase; Region: PLN02442 869729009596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 869729009597 lac repressor; Reviewed; Region: lacI; PRK09526 869729009598 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869729009599 DNA binding site [nucleotide binding] 869729009600 domain linker motif; other site 869729009601 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 869729009602 ligand binding site [chemical binding]; other site 869729009603 dimerization interface (open form) [polypeptide binding]; other site 869729009604 dimerization interface (closed form) [polypeptide binding]; other site 869729009605 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 869729009606 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 869729009607 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 869729009608 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 869729009609 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 869729009610 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 869729009611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729009612 putative substrate translocation pore; other site 869729009613 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 869729009614 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 869729009615 active site 869729009616 substrate binding site [chemical binding]; other site 869729009617 trimer interface [polypeptide binding]; other site 869729009618 CoA binding site [chemical binding]; other site 869729009619 cytosine deaminase; Provisional; Region: PRK09230 869729009620 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 869729009621 active site 869729009622 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 869729009623 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 869729009624 Na binding site [ion binding]; other site 869729009625 putative substrate binding site [chemical binding]; other site 869729009626 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 869729009627 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 869729009628 acyl-activating enzyme (AAE) consensus motif; other site 869729009629 putative AMP binding site [chemical binding]; other site 869729009630 putative active site [active] 869729009631 putative CoA binding site [chemical binding]; other site 869729009632 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 869729009633 2-methylcitrate dehydratase; Region: prpD; TIGR02330 869729009634 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 869729009635 dimer interface [polypeptide binding]; other site 869729009636 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 869729009637 active site 869729009638 citrylCoA binding site [chemical binding]; other site 869729009639 oxalacetate/citrate binding site [chemical binding]; other site 869729009640 coenzyme A binding site [chemical binding]; other site 869729009641 catalytic triad [active] 869729009642 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 869729009643 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 869729009644 tetramer interface [polypeptide binding]; other site 869729009645 active site 869729009646 Mg2+/Mn2+ binding site [ion binding]; other site 869729009647 potential frameshift: common BLAST hit: gi|218557259|ref|YP_002390172.1| DNA-binding transcriptional activator 869729009648 hypothetical protein; Provisional; Region: PRK09929 869729009649 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 869729009650 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 869729009651 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 869729009652 putative NAD(P) binding site [chemical binding]; other site 869729009653 putative substrate binding site [chemical binding]; other site 869729009654 catalytic Zn binding site [ion binding]; other site 869729009655 structural Zn binding site [ion binding]; other site 869729009656 dimer interface [polypeptide binding]; other site 869729009657 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869729009658 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 869729009659 TM-ABC transporter signature motif; other site 869729009660 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 869729009661 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869729009662 TM-ABC transporter signature motif; other site 869729009663 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 869729009664 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 869729009665 Walker A/P-loop; other site 869729009666 ATP binding site [chemical binding]; other site 869729009667 Q-loop/lid; other site 869729009668 ABC transporter signature motif; other site 869729009669 Walker B; other site 869729009670 D-loop; other site 869729009671 H-loop/switch region; other site 869729009672 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 869729009673 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 869729009674 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 869729009675 ligand binding site [chemical binding]; other site 869729009676 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 869729009677 putative deaminase; Validated; Region: PRK06846 869729009678 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 869729009679 active site 869729009680 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 869729009681 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 869729009682 putative substrate binding site [chemical binding]; other site 869729009683 nucleotide binding site [chemical binding]; other site 869729009684 nucleotide binding site [chemical binding]; other site 869729009685 homodimer interface [polypeptide binding]; other site 869729009686 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 869729009687 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 869729009688 CoA binding domain; Region: CoA_binding; pfam02629 869729009689 CoA-ligase; Region: Ligase_CoA; pfam00549 869729009690 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 869729009691 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 869729009692 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 869729009693 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 869729009694 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 869729009695 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 869729009696 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729009697 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 869729009698 dimerization interface [polypeptide binding]; other site 869729009699 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869729009700 DNA binding residues [nucleotide binding] 869729009701 dimerization interface [polypeptide binding]; other site 869729009702 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 869729009703 choline transport protein BetT; Provisional; Region: PRK09928 869729009704 transcriptional regulator BetI; Validated; Region: PRK00767 869729009705 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869729009706 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 869729009707 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 869729009708 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 869729009709 tetrameric interface [polypeptide binding]; other site 869729009710 NAD binding site [chemical binding]; other site 869729009711 catalytic residues [active] 869729009712 choline dehydrogenase; Validated; Region: PRK02106 869729009713 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 869729009714 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 869729009715 active site 869729009716 DNA binding site [nucleotide binding] 869729009717 Int/Topo IB signature motif; other site 869729009718 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 869729009719 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869729009720 DNA binding residues [nucleotide binding] 869729009721 dimerization interface [polypeptide binding]; other site 869729009722 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 869729009723 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 869729009724 Autotransporter beta-domain; Region: Autotransporter; pfam03797 869729009725 Uncharacterized conserved protein [Function unknown]; Region: COG1556 869729009726 iron-sulfur cluster-binding protein; Region: TIGR00273 869729009727 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 869729009728 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 869729009729 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 869729009730 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 869729009731 Cysteine-rich domain; Region: CCG; pfam02754 869729009732 Cysteine-rich domain; Region: CCG; pfam02754 869729009733 Cupin; Region: Cupin_6; pfam12852 869729009734 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 869729009735 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729009736 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 869729009737 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 869729009738 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869729009739 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 869729009740 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 869729009741 Predicted membrane protein [Function unknown]; Region: COG3059 869729009742 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 869729009743 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 869729009744 active site 869729009745 catalytic tetrad [active] 869729009746 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 869729009747 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729009748 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 869729009749 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 869729009750 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 869729009751 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 869729009752 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 869729009753 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 869729009754 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 869729009755 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 869729009756 active site 869729009757 catalytic tetrad [active] 869729009758 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 869729009759 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 869729009760 active site 869729009761 catalytic tetrad [active] 869729009762 Transcriptional regulator [Transcription]; Region: LysR; COG0583 869729009763 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729009764 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 869729009765 putative effector binding pocket; other site 869729009766 putative dimerization interface [polypeptide binding]; other site 869729009767 Transcriptional regulator [Transcription]; Region: LysR; COG0583 869729009768 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729009769 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 869729009770 putative effector binding pocket; other site 869729009771 putative dimerization interface [polypeptide binding]; other site 869729009772 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 869729009773 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 869729009774 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 869729009775 putative active site [active] 869729009776 putative FMN binding site [chemical binding]; other site 869729009777 putative substrate binding site [chemical binding]; other site 869729009778 putative catalytic residue [active] 869729009779 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 869729009780 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 869729009781 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 869729009782 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869729009783 DNA binding residues [nucleotide binding] 869729009784 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 869729009785 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 869729009786 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 869729009787 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 869729009788 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 869729009789 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 869729009790 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 869729009791 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 869729009792 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 869729009793 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 869729009794 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 869729009795 Autotransporter beta-domain; Region: Autotransporter; pfam03797 869729009796 MarR family; Region: MarR_2; cl17246 869729009797 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 869729009798 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 869729009799 Iron permease FTR1 family; Region: FTR1; cl00475 869729009800 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869729009801 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869729009802 non-specific DNA binding site [nucleotide binding]; other site 869729009803 salt bridge; other site 869729009804 sequence-specific DNA binding site [nucleotide binding]; other site 869729009805 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 869729009806 multiple promoter invertase; Provisional; Region: mpi; PRK13413 869729009807 catalytic residues [active] 869729009808 catalytic nucleophile [active] 869729009809 Presynaptic Site I dimer interface [polypeptide binding]; other site 869729009810 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 869729009811 Synaptic Flat tetramer interface [polypeptide binding]; other site 869729009812 Synaptic Site I dimer interface [polypeptide binding]; other site 869729009813 DNA binding site [nucleotide binding] 869729009814 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 869729009815 DNA-binding interface [nucleotide binding]; DNA binding site 869729009816 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 869729009817 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869729009818 Walker A/P-loop; other site 869729009819 ATP binding site [chemical binding]; other site 869729009820 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 869729009821 putative active site [active] 869729009822 putative metal-binding site [ion binding]; other site 869729009823 Part of AAA domain; Region: AAA_19; pfam13245 869729009824 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 869729009825 NIPSNAP; Region: NIPSNAP; pfam07978 869729009826 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 869729009827 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 869729009828 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 869729009829 Int/Topo IB signature motif; other site 869729009830 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 869729009831 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 869729009832 putative catalytic cysteine [active] 869729009833 gamma-glutamyl kinase; Provisional; Region: PRK05429 869729009834 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 869729009835 nucleotide binding site [chemical binding]; other site 869729009836 homotetrameric interface [polypeptide binding]; other site 869729009837 putative phosphate binding site [ion binding]; other site 869729009838 putative allosteric binding site; other site 869729009839 PUA domain; Region: PUA; pfam01472 869729009840 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 869729009841 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 869729009842 trimer interface [polypeptide binding]; other site 869729009843 eyelet of channel; other site 869729009844 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 869729009845 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 869729009846 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869729009847 active site 869729009848 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 869729009849 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 869729009850 metal binding site [ion binding]; metal-binding site 869729009851 dimer interface [polypeptide binding]; other site 869729009852 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 869729009853 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 869729009854 hypothetical protein; Reviewed; Region: PRK09588 869729009855 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 869729009856 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 869729009857 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869729009858 Coenzyme A binding pocket [chemical binding]; other site 869729009859 putative toxin YafO; Provisional; Region: PRK09885 869729009860 putative antitoxin of the YafO-YafN toxin-antitoxin system; Provisional; Region: PRK09778 869729009861 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 869729009862 active site 869729009863 DNA polymerase IV; Validated; Region: PRK02406 869729009864 DNA binding site [nucleotide binding] 869729009865 hypothetical protein; Validated; Region: PRK06778 869729009866 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 869729009867 ligand binding site [chemical binding]; other site 869729009868 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 869729009869 FHIPEP family; Region: FHIPEP; pfam00771 869729009870 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 869729009871 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 869729009872 NlpC/P60 family; Region: NLPC_P60; pfam00877 869729009873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 869729009874 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 869729009875 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 869729009876 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 869729009877 putative active site [active] 869729009878 putative dimer interface [polypeptide binding]; other site 869729009879 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 869729009880 dimer interface [polypeptide binding]; other site 869729009881 active site 869729009882 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 869729009883 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 869729009884 active site 869729009885 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 869729009886 C-lysozyme inhibitor; Provisional; Region: PRK09993 869729009887 C-N hydrolase family amidase; Provisional; Region: PRK10438 869729009888 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 869729009889 putative active site [active] 869729009890 catalytic triad [active] 869729009891 dimer interface [polypeptide binding]; other site 869729009892 multimer interface [polypeptide binding]; other site 869729009893 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 869729009894 Transposase [DNA replication, recombination, and repair]; Region: COG5433 869729009895 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 869729009896 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 869729009897 putative active site [active] 869729009898 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 869729009899 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 869729009900 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 869729009901 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 869729009902 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 869729009903 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 869729009904 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 869729009905 Protein of unknown function (DUF770); Region: DUF770; pfam05591 869729009906 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 869729009907 Protein of unknown function (DUF877); Region: DUF877; pfam05943 869729009908 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 869729009909 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 869729009910 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 869729009911 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 869729009912 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 869729009913 FHA domain; Region: FHA; pfam00498 869729009914 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 869729009915 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 869729009916 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 869729009917 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 869729009918 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 869729009919 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729009920 Walker A motif; other site 869729009921 ATP binding site [chemical binding]; other site 869729009922 Walker B motif; other site 869729009923 arginine finger; other site 869729009924 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729009925 Walker A motif; other site 869729009926 ATP binding site [chemical binding]; other site 869729009927 Walker B motif; other site 869729009928 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 869729009929 type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360 869729009930 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 869729009931 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 869729009932 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 869729009933 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 869729009934 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 869729009935 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 869729009936 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 869729009937 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 869729009938 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 869729009939 active site 869729009940 catalytic site [active] 869729009941 substrate binding site [chemical binding]; other site 869729009942 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 869729009943 RNA/DNA hybrid binding site [nucleotide binding]; other site 869729009944 active site 869729009945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729009946 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 869729009947 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 869729009948 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 869729009949 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 869729009950 N-acetyl-D-glucosamine binding site [chemical binding]; other site 869729009951 catalytic residue [active] 869729009952 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 869729009953 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869729009954 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 869729009955 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869729009956 Methyltransferase domain; Region: Methyltransf_31; pfam13847 869729009957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729009958 S-adenosylmethionine binding site [chemical binding]; other site 869729009959 hypothetical protein; Provisional; Region: PRK05421 869729009960 putative catalytic site [active] 869729009961 putative metal binding site [ion binding]; other site 869729009962 putative phosphate binding site [ion binding]; other site 869729009963 putative catalytic site [active] 869729009964 putative phosphate binding site [ion binding]; other site 869729009965 putative metal binding site [ion binding]; other site 869729009966 Transcriptional regulator [Transcription]; Region: LysR; COG0583 869729009967 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729009968 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 869729009969 putative effector binding pocket; other site 869729009970 dimerization interface [polypeptide binding]; other site 869729009971 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 869729009972 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 869729009973 active site 869729009974 catalytic tetrad [active] 869729009975 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 869729009976 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 869729009977 trimer interface [polypeptide binding]; other site 869729009978 putative metal binding site [ion binding]; other site 869729009979 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 869729009980 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 869729009981 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 869729009982 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 869729009983 shikimate binding site; other site 869729009984 NAD(P) binding site [chemical binding]; other site 869729009985 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 869729009986 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 869729009987 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 869729009988 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 869729009989 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 869729009990 hypothetical protein; Validated; Region: PRK03430 869729009991 hypothetical protein; Provisional; Region: PRK10736 869729009992 DNA protecting protein DprA; Region: dprA; TIGR00732 869729009993 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 869729009994 active site 869729009995 catalytic residues [active] 869729009996 metal binding site [ion binding]; metal-binding site 869729009997 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 869729009998 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 869729009999 putative active site [active] 869729010000 substrate binding site [chemical binding]; other site 869729010001 putative cosubstrate binding site; other site 869729010002 catalytic site [active] 869729010003 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 869729010004 substrate binding site [chemical binding]; other site 869729010005 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 869729010006 putative RNA binding site [nucleotide binding]; other site 869729010007 16S rRNA methyltransferase B; Provisional; Region: PRK10901 869729010008 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729010009 S-adenosylmethionine binding site [chemical binding]; other site 869729010010 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 869729010011 TrkA-N domain; Region: TrkA_N; pfam02254 869729010012 TrkA-C domain; Region: TrkA_C; pfam02080 869729010013 TrkA-N domain; Region: TrkA_N; pfam02254 869729010014 TrkA-C domain; Region: TrkA_C; pfam02080 869729010015 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 869729010016 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 869729010017 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 869729010018 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 869729010019 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 869729010020 DNA binding residues [nucleotide binding] 869729010021 dimer interface [polypeptide binding]; other site 869729010022 metal binding site [ion binding]; metal-binding site 869729010023 hypothetical protein; Provisional; Region: PRK10203 869729010024 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 869729010025 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 869729010026 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 869729010027 alphaNTD homodimer interface [polypeptide binding]; other site 869729010028 alphaNTD - beta interaction site [polypeptide binding]; other site 869729010029 alphaNTD - beta' interaction site [polypeptide binding]; other site 869729010030 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 869729010031 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 869729010032 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 869729010033 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869729010034 RNA binding surface [nucleotide binding]; other site 869729010035 30S ribosomal protein S11; Validated; Region: PRK05309 869729010036 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 869729010037 30S ribosomal protein S13; Region: bact_S13; TIGR03631 869729010038 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 869729010039 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 869729010040 SecY translocase; Region: SecY; pfam00344 869729010041 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 869729010042 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 869729010043 23S rRNA binding site [nucleotide binding]; other site 869729010044 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 869729010045 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 869729010046 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 869729010047 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 869729010048 23S rRNA interface [nucleotide binding]; other site 869729010049 5S rRNA interface [nucleotide binding]; other site 869729010050 L27 interface [polypeptide binding]; other site 869729010051 L5 interface [polypeptide binding]; other site 869729010052 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 869729010053 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 869729010054 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 869729010055 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 869729010056 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 869729010057 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 869729010058 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 869729010059 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 869729010060 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 869729010061 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 869729010062 RNA binding site [nucleotide binding]; other site 869729010063 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 869729010064 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 869729010065 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 869729010066 23S rRNA interface [nucleotide binding]; other site 869729010067 putative translocon interaction site; other site 869729010068 signal recognition particle (SRP54) interaction site; other site 869729010069 L23 interface [polypeptide binding]; other site 869729010070 trigger factor interaction site; other site 869729010071 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 869729010072 23S rRNA interface [nucleotide binding]; other site 869729010073 5S rRNA interface [nucleotide binding]; other site 869729010074 putative antibiotic binding site [chemical binding]; other site 869729010075 L25 interface [polypeptide binding]; other site 869729010076 L27 interface [polypeptide binding]; other site 869729010077 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 869729010078 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 869729010079 G-X-X-G motif; other site 869729010080 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 869729010081 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 869729010082 protein-rRNA interface [nucleotide binding]; other site 869729010083 putative translocon binding site; other site 869729010084 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 869729010085 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 869729010086 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 869729010087 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 869729010088 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 869729010089 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 869729010090 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 869729010091 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 869729010092 protein secretion protein GspB; Provisional; Region: PRK09697 869729010093 AAA domain; Region: AAA_22; pfam13401 869729010094 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 869729010095 Type II secretory pathway, component PulC [Intracellular trafficking and secretion]; Region: PulC; COG3031 869729010096 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 869729010097 type II secretion system protein D; Region: type_II_gspD; TIGR02517 869729010098 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 869729010099 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 869729010100 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 869729010101 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 869729010102 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 869729010103 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 869729010104 Walker A motif; other site 869729010105 ATP binding site [chemical binding]; other site 869729010106 Walker B motif; other site 869729010107 type II secretion system protein F; Region: GspF; TIGR02120 869729010108 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 869729010109 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 869729010110 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 869729010111 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 869729010112 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 869729010113 Type II transport protein GspH; Region: GspH; pfam12019 869729010114 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 869729010115 type II secretion system protein I; Region: gspI; TIGR01707 869729010116 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 869729010117 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 869729010118 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 869729010119 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 869729010120 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 869729010121 Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297 869729010122 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 869729010123 GspL periplasmic domain; Region: GspL_C; pfam12693 869729010124 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 869729010125 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 869729010126 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 869729010127 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 869729010128 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 869729010129 heme binding site [chemical binding]; other site 869729010130 ferroxidase pore; other site 869729010131 ferroxidase diiron center [ion binding]; other site 869729010132 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 869729010133 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 869729010134 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 869729010135 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 869729010136 aromatic chitin/cellulose binding site residues [chemical binding]; other site 869729010137 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 869729010138 active site 869729010139 elongation factor Tu; Reviewed; Region: PRK00049 869729010140 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 869729010141 G1 box; other site 869729010142 GEF interaction site [polypeptide binding]; other site 869729010143 GTP/Mg2+ binding site [chemical binding]; other site 869729010144 Switch I region; other site 869729010145 G2 box; other site 869729010146 G3 box; other site 869729010147 Switch II region; other site 869729010148 G4 box; other site 869729010149 G5 box; other site 869729010150 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 869729010151 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 869729010152 Antibiotic Binding Site [chemical binding]; other site 869729010153 potential protein location (hypothetical protein UM146_16610 [Escherichia coli UM146]) that overlaps RNA (tRNA-T) 869729010154 pantothenate kinase; Provisional; Region: PRK05439 869729010155 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 869729010156 ATP-binding site [chemical binding]; other site 869729010157 CoA-binding site [chemical binding]; other site 869729010158 Mg2+-binding site [ion binding]; other site 869729010159 Biotin operon repressor [Transcription]; Region: BirA; COG1654 869729010160 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 869729010161 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 869729010162 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 869729010163 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 869729010164 FAD binding domain; Region: FAD_binding_4; pfam01565 869729010165 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 869729010166 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 869729010167 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 869729010168 purine monophosphate binding site [chemical binding]; other site 869729010169 dimer interface [polypeptide binding]; other site 869729010170 putative catalytic residues [active] 869729010171 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 869729010172 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 869729010173 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 869729010174 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 869729010175 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 869729010176 potential frameshift: common BLAST hit: gi|218561070|ref|YP_002393983.1| transcriptional regulatory protein ZraR 869729010177 sensor protein ZraS; Provisional; Region: PRK10364 869729010178 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869729010179 dimer interface [polypeptide binding]; other site 869729010180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729010181 ATP binding site [chemical binding]; other site 869729010182 Mg2+ binding site [ion binding]; other site 869729010183 G-X-G motif; other site 869729010184 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 869729010185 dimer interface [polypeptide binding]; other site 869729010186 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 869729010187 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 869729010188 IHF dimer interface [polypeptide binding]; other site 869729010189 IHF - DNA interface [nucleotide binding]; other site 869729010190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 869729010191 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 869729010192 Active_site [active] 869729010193 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 869729010194 substrate binding site [chemical binding]; other site 869729010195 active site 869729010196 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 869729010197 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 869729010198 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 869729010199 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 869729010200 putative NADH binding site [chemical binding]; other site 869729010201 putative active site [active] 869729010202 nudix motif; other site 869729010203 putative metal binding site [ion binding]; other site 869729010204 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 869729010205 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 869729010206 ThiC-associated domain; Region: ThiC-associated; pfam13667 869729010207 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 869729010208 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 869729010209 thiamine phosphate binding site [chemical binding]; other site 869729010210 active site 869729010211 pyrophosphate binding site [ion binding]; other site 869729010212 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 869729010213 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 869729010214 ATP binding site [chemical binding]; other site 869729010215 substrate interface [chemical binding]; other site 869729010216 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 869729010217 thiS-thiF/thiG interaction site; other site 869729010218 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 869729010219 ThiS interaction site; other site 869729010220 putative active site [active] 869729010221 tetramer interface [polypeptide binding]; other site 869729010222 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 869729010223 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869729010224 FeS/SAM binding site; other site 869729010225 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 869729010226 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 869729010227 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 869729010228 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 869729010229 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 869729010230 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 869729010231 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 869729010232 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 869729010233 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 869729010234 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 869729010235 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 869729010236 DNA binding site [nucleotide binding] 869729010237 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 869729010238 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 869729010239 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 869729010240 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 869729010241 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 869729010242 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 869729010243 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 869729010244 RPB3 interaction site [polypeptide binding]; other site 869729010245 RPB1 interaction site [polypeptide binding]; other site 869729010246 RPB11 interaction site [polypeptide binding]; other site 869729010247 RPB10 interaction site [polypeptide binding]; other site 869729010248 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 869729010249 core dimer interface [polypeptide binding]; other site 869729010250 peripheral dimer interface [polypeptide binding]; other site 869729010251 L10 interface [polypeptide binding]; other site 869729010252 L11 interface [polypeptide binding]; other site 869729010253 putative EF-Tu interaction site [polypeptide binding]; other site 869729010254 putative EF-G interaction site [polypeptide binding]; other site 869729010255 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 869729010256 23S rRNA interface [nucleotide binding]; other site 869729010257 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 869729010258 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 869729010259 mRNA/rRNA interface [nucleotide binding]; other site 869729010260 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 869729010261 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 869729010262 23S rRNA interface [nucleotide binding]; other site 869729010263 L7/L12 interface [polypeptide binding]; other site 869729010264 putative thiostrepton binding site; other site 869729010265 L25 interface [polypeptide binding]; other site 869729010266 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 869729010267 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 869729010268 putative homodimer interface [polypeptide binding]; other site 869729010269 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 869729010270 heterodimer interface [polypeptide binding]; other site 869729010271 homodimer interface [polypeptide binding]; other site 869729010272 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 869729010273 elongation factor Tu; Reviewed; Region: PRK00049 869729010274 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 869729010275 G1 box; other site 869729010276 GEF interaction site [polypeptide binding]; other site 869729010277 GTP/Mg2+ binding site [chemical binding]; other site 869729010278 Switch I region; other site 869729010279 G2 box; other site 869729010280 G3 box; other site 869729010281 Switch II region; other site 869729010282 G4 box; other site 869729010283 G5 box; other site 869729010284 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 869729010285 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 869729010286 Antibiotic Binding Site [chemical binding]; other site 869729010287 elongation factor G; Reviewed; Region: PRK00007 869729010288 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 869729010289 G1 box; other site 869729010290 putative GEF interaction site [polypeptide binding]; other site 869729010291 GTP/Mg2+ binding site [chemical binding]; other site 869729010292 Switch I region; other site 869729010293 G2 box; other site 869729010294 G3 box; other site 869729010295 Switch II region; other site 869729010296 G4 box; other site 869729010297 G5 box; other site 869729010298 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 869729010299 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 869729010300 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 869729010301 30S ribosomal protein S7; Validated; Region: PRK05302 869729010302 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 869729010303 S17 interaction site [polypeptide binding]; other site 869729010304 S8 interaction site; other site 869729010305 16S rRNA interaction site [nucleotide binding]; other site 869729010306 streptomycin interaction site [chemical binding]; other site 869729010307 23S rRNA interaction site [nucleotide binding]; other site 869729010308 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 869729010309 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 869729010310 sulfur relay protein TusC; Validated; Region: PRK00211 869729010311 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 869729010312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 869729010313 YheO-like PAS domain; Region: PAS_6; pfam08348 869729010314 HTH domain; Region: HTH_22; pfam13309 869729010315 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 869729010316 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 869729010317 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 869729010318 phi X174 lysis protein; Provisional; Region: PRK02793 869729010319 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 869729010320 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 869729010321 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 869729010322 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 869729010323 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 869729010324 TrkA-N domain; Region: TrkA_N; pfam02254 869729010325 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 869729010326 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 869729010327 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869729010328 Walker A/P-loop; other site 869729010329 ATP binding site [chemical binding]; other site 869729010330 Q-loop/lid; other site 869729010331 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869729010332 ABC transporter signature motif; other site 869729010333 Walker B; other site 869729010334 D-loop; other site 869729010335 ABC transporter; Region: ABC_tran_2; pfam12848 869729010336 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869729010337 putative hydrolase; Provisional; Region: PRK10985 869729010338 hypothetical protein; Provisional; Region: PRK04966 869729010339 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 869729010340 active site 869729010341 hypothetical protein; Provisional; Region: PRK10738 869729010342 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 869729010343 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 869729010344 ligand binding site [chemical binding]; other site 869729010345 flexible hinge region; other site 869729010346 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 869729010347 putative switch regulator; other site 869729010348 non-specific DNA interactions [nucleotide binding]; other site 869729010349 DNA binding site [nucleotide binding] 869729010350 sequence specific DNA binding site [nucleotide binding]; other site 869729010351 putative cAMP binding site [chemical binding]; other site 869729010352 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 869729010353 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 869729010354 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 869729010355 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 869729010356 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 869729010357 inhibitor-cofactor binding pocket; inhibition site 869729010358 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729010359 catalytic residue [active] 869729010360 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 869729010361 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 869729010362 glutamine binding [chemical binding]; other site 869729010363 catalytic triad [active] 869729010364 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 869729010365 cell filamentation protein Fic; Provisional; Region: PRK10347 869729010366 hypothetical protein; Provisional; Region: PRK10204 869729010367 potential frameshift: common BLAST hit: gi|383180527|ref|YP_005458532.1| peptidyl-prolyl cis-trans isomerase A 869729010368 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 869729010369 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 869729010370 putative transporter; Provisional; Region: PRK03699 869729010371 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729010372 putative substrate translocation pore; other site 869729010373 nitrite reductase subunit NirD; Provisional; Region: PRK14989 869729010374 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869729010375 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 869729010376 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 869729010377 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 869729010378 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 869729010379 nitrite transporter NirC; Provisional; Region: PRK11562 869729010380 siroheme synthase; Provisional; Region: cysG; PRK10637 869729010381 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 869729010382 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 869729010383 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 869729010384 active site 869729010385 SAM binding site [chemical binding]; other site 869729010386 homodimer interface [polypeptide binding]; other site 869729010387 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 869729010388 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 869729010389 Protein of unknown function; Region: YhfT; pfam10797 869729010390 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 869729010391 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 869729010392 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 869729010393 active site 869729010394 substrate binding pocket [chemical binding]; other site 869729010395 homodimer interaction site [polypeptide binding]; other site 869729010396 putative mutase; Provisional; Region: PRK12383 869729010397 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015 869729010398 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 869729010399 dimer interface [polypeptide binding]; other site 869729010400 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 869729010401 active site 869729010402 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869729010403 substrate binding site [chemical binding]; other site 869729010404 catalytic residue [active] 869729010405 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 869729010406 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 869729010407 active site 869729010408 HIGH motif; other site 869729010409 dimer interface [polypeptide binding]; other site 869729010410 KMSKS motif; other site 869729010411 phosphoglycolate phosphatase; Provisional; Region: PRK13222 869729010412 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869729010413 motif II; other site 869729010414 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 869729010415 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 869729010416 substrate binding site [chemical binding]; other site 869729010417 hexamer interface [polypeptide binding]; other site 869729010418 metal binding site [ion binding]; metal-binding site 869729010419 DNA adenine methylase; Provisional; Region: PRK10904 869729010420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 869729010421 cell division protein DamX; Validated; Region: PRK10905 869729010422 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 869729010423 active site 869729010424 dimer interface [polypeptide binding]; other site 869729010425 metal binding site [ion binding]; metal-binding site 869729010426 shikimate kinase; Reviewed; Region: aroK; PRK00131 869729010427 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 869729010428 ADP binding site [chemical binding]; other site 869729010429 magnesium binding site [ion binding]; other site 869729010430 putative shikimate binding site; other site 869729010431 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 869729010432 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 869729010433 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 869729010434 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 869729010435 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 869729010436 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 869729010437 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 869729010438 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 869729010439 Transglycosylase; Region: Transgly; pfam00912 869729010440 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 869729010441 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 869729010442 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 869729010443 ADP-ribose binding site [chemical binding]; other site 869729010444 dimer interface [polypeptide binding]; other site 869729010445 active site 869729010446 nudix motif; other site 869729010447 metal binding site [ion binding]; metal-binding site 869729010448 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 869729010449 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 869729010450 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869729010451 motif II; other site 869729010452 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869729010453 RNA binding surface [nucleotide binding]; other site 869729010454 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 869729010455 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 869729010456 dimerization interface [polypeptide binding]; other site 869729010457 domain crossover interface; other site 869729010458 redox-dependent activation switch; other site 869729010459 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 869729010460 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 869729010461 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 869729010462 active site 869729010463 substrate-binding site [chemical binding]; other site 869729010464 metal-binding site [ion binding] 869729010465 ATP binding site [chemical binding]; other site 869729010466 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 869729010467 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869729010468 dimerization interface [polypeptide binding]; other site 869729010469 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869729010470 dimer interface [polypeptide binding]; other site 869729010471 phosphorylation site [posttranslational modification] 869729010472 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729010473 ATP binding site [chemical binding]; other site 869729010474 G-X-G motif; other site 869729010475 osmolarity response regulator; Provisional; Region: ompR; PRK09468 869729010476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729010477 active site 869729010478 phosphorylation site [posttranslational modification] 869729010479 intermolecular recognition site; other site 869729010480 dimerization interface [polypeptide binding]; other site 869729010481 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869729010482 DNA binding site [nucleotide binding] 869729010483 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 869729010484 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 869729010485 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 869729010486 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 869729010487 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 869729010488 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 869729010489 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 869729010490 RNA binding site [nucleotide binding]; other site 869729010491 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 869729010492 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 869729010493 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 869729010494 G1 box; other site 869729010495 GTP/Mg2+ binding site [chemical binding]; other site 869729010496 Switch I region; other site 869729010497 G2 box; other site 869729010498 G3 box; other site 869729010499 Switch II region; other site 869729010500 G4 box; other site 869729010501 G5 box; other site 869729010502 Nucleoside recognition; Region: Gate; pfam07670 869729010503 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 869729010504 Nucleoside recognition; Region: Gate; pfam07670 869729010505 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 869729010506 putative transposase; Provisional; Region: PRK09857 869729010507 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 869729010508 carboxylesterase BioH; Provisional; Region: PRK10349 869729010509 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 869729010510 DNA utilization protein GntX; Provisional; Region: PRK11595 869729010511 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869729010512 active site 869729010513 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 869729010514 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 869729010515 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 869729010516 high-affinity gluconate transporter; Provisional; Region: PRK14984 869729010517 gluconate transporter; Region: gntP; TIGR00791 869729010518 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 869729010519 4-alpha-glucanotransferase; Region: malQ; TIGR00217 869729010520 maltodextrin phosphorylase; Provisional; Region: PRK14985 869729010521 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 869729010522 homodimer interface [polypeptide binding]; other site 869729010523 active site pocket [active] 869729010524 transcriptional regulator MalT; Provisional; Region: PRK04841 869729010525 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869729010526 DNA binding residues [nucleotide binding] 869729010527 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 869729010528 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 869729010529 putative active site [active] 869729010530 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 869729010531 hypothetical protein; Reviewed; Region: PRK09588 869729010532 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 869729010533 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 869729010534 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729010535 Walker A motif; other site 869729010536 ATP binding site [chemical binding]; other site 869729010537 Walker B motif; other site 869729010538 arginine finger; other site 869729010539 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 869729010540 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 869729010541 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869729010542 intramembrane serine protease GlpG; Provisional; Region: PRK10907 869729010543 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 869729010544 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 869729010545 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 869729010546 active site residue [active] 869729010547 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 869729010548 hypothetical protein; Provisional; Region: PRK09781; cl08057 869729010549 potential frameshift: common BLAST hit: gi|218560486|ref|YP_002393399.1| putative fimbrial-like adhesin protein AufG 869729010550 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 869729010551 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 869729010552 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 869729010553 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 869729010554 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 869729010555 outer membrane usher protein; Provisional; Region: PRK15193 869729010556 PapC N-terminal domain; Region: PapC_N; pfam13954 869729010557 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 869729010558 PapC C-terminal domain; Region: PapC_C; pfam13953 869729010559 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 869729010560 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 869729010561 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 869729010562 glycogen phosphorylase; Provisional; Region: PRK14986 869729010563 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 869729010564 homodimer interface [polypeptide binding]; other site 869729010565 active site pocket [active] 869729010566 glycogen synthase; Provisional; Region: glgA; PRK00654 869729010567 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 869729010568 ADP-binding pocket [chemical binding]; other site 869729010569 homodimer interface [polypeptide binding]; other site 869729010570 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 869729010571 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 869729010572 ligand binding site; other site 869729010573 oligomer interface; other site 869729010574 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 869729010575 sulfate 1 binding site; other site 869729010576 glycogen debranching enzyme; Provisional; Region: PRK03705 869729010577 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 869729010578 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 869729010579 active site 869729010580 catalytic site [active] 869729010581 glycogen branching enzyme; Provisional; Region: PRK05402 869729010582 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 869729010583 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 869729010584 active site 869729010585 catalytic site [active] 869729010586 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 869729010587 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 869729010588 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 869729010589 putative antibiotic transporter; Provisional; Region: PRK10739 869729010590 low affinity gluconate transporter; Provisional; Region: PRK10472 869729010591 gluconate transporter; Region: gntP; TIGR00791 869729010592 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 869729010593 Shikimate kinase; Region: SKI; pfam01202 869729010594 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 869729010595 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869729010596 DNA binding site [nucleotide binding] 869729010597 domain linker motif; other site 869729010598 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 869729010599 putative ligand binding site [chemical binding]; other site 869729010600 putative dimerization interface [polypeptide binding]; other site 869729010601 Pirin-related protein [General function prediction only]; Region: COG1741 869729010602 Pirin; Region: Pirin; pfam02678 869729010603 putative oxidoreductase; Provisional; Region: PRK10206 869729010604 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 869729010605 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 869729010606 putative acetyltransferase YhhY; Provisional; Region: PRK10140 869729010607 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869729010608 Coenzyme A binding pocket [chemical binding]; other site 869729010609 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 869729010610 YopJ Serine/Threonine acetyltransferase; Region: YopJ; cl07849 869729010611 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 869729010612 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 869729010613 hypothetical protein; Provisional; Region: PRK10350 869729010614 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 869729010615 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 869729010616 putative active site [active] 869729010617 catalytic site [active] 869729010618 putative metal binding site [ion binding]; other site 869729010619 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 869729010620 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 869729010621 Walker A/P-loop; other site 869729010622 ATP binding site [chemical binding]; other site 869729010623 Q-loop/lid; other site 869729010624 ABC transporter signature motif; other site 869729010625 Walker B; other site 869729010626 D-loop; other site 869729010627 H-loop/switch region; other site 869729010628 TOBE domain; Region: TOBE_2; pfam08402 869729010629 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869729010630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729010631 dimer interface [polypeptide binding]; other site 869729010632 conserved gate region; other site 869729010633 putative PBP binding loops; other site 869729010634 ABC-ATPase subunit interface; other site 869729010635 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 869729010636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729010637 dimer interface [polypeptide binding]; other site 869729010638 conserved gate region; other site 869729010639 putative PBP binding loops; other site 869729010640 ABC-ATPase subunit interface; other site 869729010641 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 869729010642 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869729010643 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 869729010644 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 869729010645 Walker A/P-loop; other site 869729010646 ATP binding site [chemical binding]; other site 869729010647 Q-loop/lid; other site 869729010648 ABC transporter signature motif; other site 869729010649 Walker B; other site 869729010650 D-loop; other site 869729010651 H-loop/switch region; other site 869729010652 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 869729010653 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 869729010654 Walker A/P-loop; other site 869729010655 ATP binding site [chemical binding]; other site 869729010656 Q-loop/lid; other site 869729010657 ABC transporter signature motif; other site 869729010658 Walker B; other site 869729010659 D-loop; other site 869729010660 H-loop/switch region; other site 869729010661 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 869729010662 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 869729010663 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 869729010664 TM-ABC transporter signature motif; other site 869729010665 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869729010666 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 869729010667 TM-ABC transporter signature motif; other site 869729010668 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 869729010669 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 869729010670 dimerization interface [polypeptide binding]; other site 869729010671 ligand binding site [chemical binding]; other site 869729010672 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 869729010673 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 869729010674 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 869729010675 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 869729010676 dimerization interface [polypeptide binding]; other site 869729010677 ligand binding site [chemical binding]; other site 869729010678 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 869729010679 active pocket/dimerization site; other site 869729010680 active site 869729010681 phosphorylation site [posttranslational modification] 869729010682 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 869729010683 active site 869729010684 phosphorylation site [posttranslational modification] 869729010685 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 869729010686 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 869729010687 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 869729010688 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 869729010689 putative ligand binding site [chemical binding]; other site 869729010690 putative NAD binding site [chemical binding]; other site 869729010691 catalytic site [active] 869729010692 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 869729010693 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 869729010694 inhibitor site; inhibition site 869729010695 active site 869729010696 dimer interface [polypeptide binding]; other site 869729010697 catalytic residue [active] 869729010698 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 869729010699 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 869729010700 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 869729010701 DNA binding residues [nucleotide binding] 869729010702 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 869729010703 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 869729010704 cell division protein FtsE; Provisional; Region: PRK10908 869729010705 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869729010706 Walker A/P-loop; other site 869729010707 ATP binding site [chemical binding]; other site 869729010708 Q-loop/lid; other site 869729010709 ABC transporter signature motif; other site 869729010710 Walker B; other site 869729010711 D-loop; other site 869729010712 H-loop/switch region; other site 869729010713 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 869729010714 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 869729010715 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 869729010716 P loop; other site 869729010717 GTP binding site [chemical binding]; other site 869729010718 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 869729010719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729010720 S-adenosylmethionine binding site [chemical binding]; other site 869729010721 hypothetical protein; Provisional; Region: PRK10910 869729010722 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 869729010723 Predicted membrane protein [Function unknown]; Region: COG3714 869729010724 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 869729010725 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 869729010726 metal-binding site [ion binding] 869729010727 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 869729010728 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 869729010729 CPxP motif; other site 869729010730 hypothetical protein; Provisional; Region: PRK11212 869729010731 hypothetical protein; Provisional; Region: PRK11615 869729010732 major facilitator superfamily transporter; Provisional; Region: PRK05122 869729010733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729010734 putative substrate translocation pore; other site 869729010735 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 869729010736 Domain of unknown function DUF20; Region: UPF0118; pfam01594 869729010737 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 869729010738 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 869729010739 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 869729010740 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 869729010741 substrate binding site [chemical binding]; other site 869729010742 nickel transporter permease NikB; Provisional; Region: PRK10352 869729010743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729010744 dimer interface [polypeptide binding]; other site 869729010745 conserved gate region; other site 869729010746 putative PBP binding loops; other site 869729010747 ABC-ATPase subunit interface; other site 869729010748 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 869729010749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729010750 dimer interface [polypeptide binding]; other site 869729010751 conserved gate region; other site 869729010752 putative PBP binding loops; other site 869729010753 ABC-ATPase subunit interface; other site 869729010754 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 869729010755 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869729010756 Walker A/P-loop; other site 869729010757 ATP binding site [chemical binding]; other site 869729010758 Q-loop/lid; other site 869729010759 ABC transporter signature motif; other site 869729010760 Walker B; other site 869729010761 D-loop; other site 869729010762 H-loop/switch region; other site 869729010763 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 869729010764 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 869729010765 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869729010766 Walker A/P-loop; other site 869729010767 ATP binding site [chemical binding]; other site 869729010768 Q-loop/lid; other site 869729010769 ABC transporter signature motif; other site 869729010770 Walker B; other site 869729010771 D-loop; other site 869729010772 H-loop/switch region; other site 869729010773 nickel responsive regulator; Provisional; Region: PRK02967 869729010774 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 869729010775 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 869729010776 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869729010777 DNA-binding site [nucleotide binding]; DNA binding site 869729010778 UTRA domain; Region: UTRA; pfam07702 869729010779 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869729010780 active site 869729010781 phosphorylation site [posttranslational modification] 869729010782 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 869729010783 active site 869729010784 P-loop; other site 869729010785 phosphorylation site [posttranslational modification] 869729010786 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 869729010787 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 869729010788 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 869729010789 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 869729010790 putative N- and C-terminal domain interface [polypeptide binding]; other site 869729010791 putative active site [active] 869729010792 putative MgATP binding site [chemical binding]; other site 869729010793 catalytic site [active] 869729010794 metal binding site [ion binding]; metal-binding site 869729010795 putative carbohydrate binding site [chemical binding]; other site 869729010796 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 869729010797 dimerization domain swap beta strand [polypeptide binding]; other site 869729010798 regulatory protein interface [polypeptide binding]; other site 869729010799 active site 869729010800 regulatory phosphorylation site [posttranslational modification]; other site 869729010801 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 869729010802 intersubunit interface [polypeptide binding]; other site 869729010803 active site 869729010804 zinc binding site [ion binding]; other site 869729010805 Na+ binding site [ion binding]; other site 869729010806 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 869729010807 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 869729010808 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869729010809 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 869729010810 Walker A/P-loop; other site 869729010811 ATP binding site [chemical binding]; other site 869729010812 Q-loop/lid; other site 869729010813 ABC transporter signature motif; other site 869729010814 Walker B; other site 869729010815 D-loop; other site 869729010816 H-loop/switch region; other site 869729010817 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869729010818 Walker A/P-loop; other site 869729010819 ATP binding site [chemical binding]; other site 869729010820 Q-loop/lid; other site 869729010821 ABC transporter signature motif; other site 869729010822 Walker B; other site 869729010823 D-loop; other site 869729010824 H-loop/switch region; other site 869729010825 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 869729010826 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 869729010827 HlyD family secretion protein; Region: HlyD; pfam00529 869729010828 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 869729010829 HlyD family secretion protein; Region: HlyD_3; pfam13437 869729010830 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 869729010831 Predicted flavoproteins [General function prediction only]; Region: COG2081 869729010832 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869729010833 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 869729010834 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 869729010835 universal stress protein UspB; Provisional; Region: PRK04960 869729010836 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 869729010837 Ligand Binding Site [chemical binding]; other site 869729010838 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 869729010839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729010840 POT family; Region: PTR2; pfam00854 869729010841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729010842 S-adenosylmethionine binding site [chemical binding]; other site 869729010843 oligopeptidase A; Provisional; Region: PRK10911 869729010844 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 869729010845 active site 869729010846 Zn binding site [ion binding]; other site 869729010847 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 869729010848 glutathione reductase; Validated; Region: PRK06116 869729010849 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869729010850 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869729010851 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 869729010852 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 869729010853 ArsC family; Region: ArsC; pfam03960 869729010854 catalytic residues [active] 869729010855 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 869729010856 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 869729010857 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869729010858 DNA binding residues [nucleotide binding] 869729010859 dimerization interface [polypeptide binding]; other site 869729010860 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 869729010861 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 869729010862 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 869729010863 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 869729010864 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 869729010865 N-terminal plug; other site 869729010866 ligand-binding site [chemical binding]; other site 869729010867 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 869729010868 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 869729010869 putative hemin binding site; other site 869729010870 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 869729010871 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869729010872 FeS/SAM binding site; other site 869729010873 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721 869729010874 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 869729010875 NADH(P)-binding; Region: NAD_binding_10; pfam13460 869729010876 NAD(P) binding site [chemical binding]; other site 869729010877 putative active site [active] 869729010878 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 869729010879 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869729010880 ABC-ATPase subunit interface; other site 869729010881 dimer interface [polypeptide binding]; other site 869729010882 putative PBP binding regions; other site 869729010883 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 869729010884 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 869729010885 Walker A/P-loop; other site 869729010886 ATP binding site [chemical binding]; other site 869729010887 Q-loop/lid; other site 869729010888 ABC transporter signature motif; other site 869729010889 Walker B; other site 869729010890 D-loop; other site 869729010891 H-loop/switch region; other site 869729010892 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 869729010893 MgtC family; Region: MgtC; pfam02308 869729010894 acid-resistance protein; Provisional; Region: hdeB; PRK11566 869729010895 acid-resistance protein; Provisional; Region: PRK10208 869729010896 acid-resistance membrane protein; Provisional; Region: PRK10209 869729010897 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 869729010898 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 869729010899 pyruvate kinase; Provisional; Region: PRK05826 869729010900 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 869729010901 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 869729010902 HlyD family secretion protein; Region: HlyD_3; pfam13437 869729010903 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 869729010904 Protein export membrane protein; Region: SecD_SecF; cl14618 869729010905 transcriptional regulator YdeO; Provisional; Region: PRK09940 869729010906 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729010907 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 869729010908 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729010909 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 869729010910 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729010911 catalytic residue [active] 869729010912 Haem-binding domain; Region: Haem_bd; pfam14376 869729010913 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 869729010914 trehalase; Provisional; Region: treF; PRK13270 869729010915 Trehalase; Region: Trehalase; pfam01204 869729010916 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 869729010917 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869729010918 DNA binding residues [nucleotide binding] 869729010919 dimerization interface [polypeptide binding]; other site 869729010920 Transcriptional regulator [Transcription]; Region: LysR; COG0583 869729010921 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729010922 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 869729010923 putative effector binding pocket; other site 869729010924 putative dimerization interface [polypeptide binding]; other site 869729010925 inner membrane protein YhjD; Region: TIGR00766 869729010926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729010927 metabolite-proton symporter; Region: 2A0106; TIGR00883 869729010928 putative substrate translocation pore; other site 869729010929 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 869729010930 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 869729010931 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 869729010932 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 869729010933 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 869729010934 substrate binding site [chemical binding]; other site 869729010935 ATP binding site [chemical binding]; other site 869729010936 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 869729010937 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 869729010938 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 869729010939 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 869729010940 putative diguanylate cyclase; Provisional; Region: PRK13561 869729010941 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 869729010942 metal binding site [ion binding]; metal-binding site 869729010943 active site 869729010944 I-site; other site 869729010945 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 869729010946 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 869729010947 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869729010948 binding surface 869729010949 TPR motif; other site 869729010950 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869729010951 binding surface 869729010952 TPR motif; other site 869729010953 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 869729010954 TPR motif; other site 869729010955 binding surface 869729010956 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 869729010957 endo-1,4-D-glucanase; Provisional; Region: PRK11097 869729010958 cellulose synthase regulator protein; Provisional; Region: PRK11114 869729010959 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 869729010960 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 869729010961 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 869729010962 DXD motif; other site 869729010963 PilZ domain; Region: PilZ; pfam07238 869729010964 cell division protein; Provisional; Region: PRK10037 869729010965 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 869729010966 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 869729010967 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 869729010968 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 869729010969 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 869729010970 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 869729010971 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 869729010972 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 869729010973 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 869729010974 serine transporter; Region: stp; TIGR00814 869729010975 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 869729010976 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869729010977 Walker A/P-loop; other site 869729010978 ATP binding site [chemical binding]; other site 869729010979 Q-loop/lid; other site 869729010980 ABC transporter signature motif; other site 869729010981 Walker B; other site 869729010982 D-loop; other site 869729010983 H-loop/switch region; other site 869729010984 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 869729010985 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 869729010986 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869729010987 Walker A/P-loop; other site 869729010988 ATP binding site [chemical binding]; other site 869729010989 Q-loop/lid; other site 869729010990 ABC transporter signature motif; other site 869729010991 Walker B; other site 869729010992 D-loop; other site 869729010993 H-loop/switch region; other site 869729010994 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 869729010995 dipeptide transporter; Provisional; Region: PRK10913 869729010996 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 869729010997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729010998 dimer interface [polypeptide binding]; other site 869729010999 conserved gate region; other site 869729011000 putative PBP binding loops; other site 869729011001 ABC-ATPase subunit interface; other site 869729011002 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 869729011003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729011004 dimer interface [polypeptide binding]; other site 869729011005 conserved gate region; other site 869729011006 putative PBP binding loops; other site 869729011007 ABC-ATPase subunit interface; other site 869729011008 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 869729011009 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 869729011010 peptide binding site [polypeptide binding]; other site 869729011011 phosphoethanolamine transferase; Provisional; Region: PRK11560 869729011012 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 869729011013 Sulfatase; Region: Sulfatase; pfam00884 869729011014 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 869729011015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729011016 putative substrate translocation pore; other site 869729011017 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 869729011018 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 869729011019 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 869729011020 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869729011021 Coenzyme A binding pocket [chemical binding]; other site 869729011022 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 869729011023 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 869729011024 molybdopterin cofactor binding site [chemical binding]; other site 869729011025 substrate binding site [chemical binding]; other site 869729011026 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 869729011027 molybdopterin cofactor binding site; other site 869729011028 putative outer membrane lipoprotein; Provisional; Region: PRK10510 869729011029 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 869729011030 ligand binding site [chemical binding]; other site 869729011031 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 869729011032 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 869729011033 dimerization interface [polypeptide binding]; other site 869729011034 ligand binding site [chemical binding]; other site 869729011035 NADP binding site [chemical binding]; other site 869729011036 catalytic site [active] 869729011037 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 869729011038 Predicted transcriptional regulator [Transcription]; Region: COG2944 869729011039 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869729011040 non-specific DNA binding site [nucleotide binding]; other site 869729011041 salt bridge; other site 869729011042 sequence-specific DNA binding site [nucleotide binding]; other site 869729011043 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 869729011044 DNA-binding site [nucleotide binding]; DNA binding site 869729011045 RNA-binding motif; other site 869729011046 small toxic polypeptide; Provisional; Region: PRK09759 869729011047 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 869729011048 DALR anticodon binding domain; Region: DALR_1; pfam05746 869729011049 anticodon binding site; other site 869729011050 tRNA binding surface [nucleotide binding]; other site 869729011051 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 869729011052 dimer interface [polypeptide binding]; other site 869729011053 motif 1; other site 869729011054 active site 869729011055 motif 2; other site 869729011056 motif 3; other site 869729011057 YsaB-like lipoprotein; Region: YsaB; pfam13983 869729011058 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 869729011059 Acyltransferase family; Region: Acyl_transf_3; pfam01757 869729011060 hypothetical protein; Provisional; Region: PRK11383 869729011061 yiaA/B two helix domain; Region: YiaAB; pfam05360 869729011062 yiaA/B two helix domain; Region: YiaAB; pfam05360 869729011063 hypothetical protein; Provisional; Region: PRK11403 869729011064 yiaA/B two helix domain; Region: YiaAB; pfam05360 869729011065 xylulokinase; Provisional; Region: PRK15027 869729011066 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 869729011067 N- and C-terminal domain interface [polypeptide binding]; other site 869729011068 active site 869729011069 MgATP binding site [chemical binding]; other site 869729011070 catalytic site [active] 869729011071 metal binding site [ion binding]; metal-binding site 869729011072 xylulose binding site [chemical binding]; other site 869729011073 homodimer interface [polypeptide binding]; other site 869729011074 xylose isomerase; Provisional; Region: PRK05474 869729011075 xylose isomerase; Region: xylose_isom_A; TIGR02630 869729011076 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 869729011077 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 869729011078 putative ligand binding site [chemical binding]; other site 869729011079 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 869729011080 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 869729011081 Walker A/P-loop; other site 869729011082 ATP binding site [chemical binding]; other site 869729011083 Q-loop/lid; other site 869729011084 ABC transporter signature motif; other site 869729011085 Walker B; other site 869729011086 D-loop; other site 869729011087 H-loop/switch region; other site 869729011088 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 869729011089 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869729011090 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 869729011091 TM-ABC transporter signature motif; other site 869729011092 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 869729011093 putative dimerization interface [polypeptide binding]; other site 869729011094 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869729011095 putative ligand binding site [chemical binding]; other site 869729011096 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729011097 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 869729011098 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729011099 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 869729011100 hypothetical protein; Provisional; Region: PRK10356 869729011101 alpha-amylase; Reviewed; Region: malS; PRK09505 869729011102 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 869729011103 active site 869729011104 catalytic site [active] 869729011105 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 869729011106 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869729011107 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729011108 homodimer interface [polypeptide binding]; other site 869729011109 catalytic residue [active] 869729011110 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 869729011111 Transcriptional regulator [Transcription]; Region: IclR; COG1414 869729011112 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 869729011113 Bacterial transcriptional regulator; Region: IclR; pfam01614 869729011114 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 869729011115 Domain of unknown function (DUF386); Region: DUF386; pfam04074 869729011116 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 869729011117 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 869729011118 DctM-like transporters; Region: DctM; pfam06808 869729011119 potential frameshift: common BLAST hit: gi|218691869|ref|YP_002400081.1| transporter 869729011120 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 869729011121 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 869729011122 putative N- and C-terminal domain interface [polypeptide binding]; other site 869729011123 putative active site [active] 869729011124 MgATP binding site [chemical binding]; other site 869729011125 catalytic site [active] 869729011126 metal binding site [ion binding]; metal-binding site 869729011127 putative xylulose binding site [chemical binding]; other site 869729011128 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 869729011129 active site 869729011130 dimer interface [polypeptide binding]; other site 869729011131 magnesium binding site [ion binding]; other site 869729011132 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 869729011133 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 869729011134 AP (apurinic/apyrimidinic) site pocket; other site 869729011135 DNA interaction; other site 869729011136 Metal-binding active site; metal-binding site 869729011137 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 869729011138 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 869729011139 intersubunit interface [polypeptide binding]; other site 869729011140 active site 869729011141 Zn2+ binding site [ion binding]; other site 869729011142 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 869729011143 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 869729011144 NAD(P) binding site [chemical binding]; other site 869729011145 catalytic residues [active] 869729011146 Fic family protein [Function unknown]; Region: COG3177 869729011147 Fic/DOC family; Region: Fic; pfam02661 869729011148 putative alcohol dehydrogenase; Provisional; Region: PRK09860 869729011149 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 869729011150 dimer interface [polypeptide binding]; other site 869729011151 active site 869729011152 metal binding site [ion binding]; metal-binding site 869729011153 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 869729011154 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 869729011155 G1 box; other site 869729011156 putative GEF interaction site [polypeptide binding]; other site 869729011157 GTP/Mg2+ binding site [chemical binding]; other site 869729011158 Switch I region; other site 869729011159 G2 box; other site 869729011160 G3 box; other site 869729011161 Switch II region; other site 869729011162 G4 box; other site 869729011163 G5 box; other site 869729011164 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 869729011165 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 869729011166 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 869729011167 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 869729011168 selenocysteine synthase; Provisional; Region: PRK04311 869729011169 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 869729011170 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 869729011171 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869729011172 catalytic residue [active] 869729011173 putative glutathione S-transferase; Provisional; Region: PRK10357 869729011174 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 869729011175 putative C-terminal domain interface [polypeptide binding]; other site 869729011176 putative GSH binding site (G-site) [chemical binding]; other site 869729011177 putative dimer interface [polypeptide binding]; other site 869729011178 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 869729011179 dimer interface [polypeptide binding]; other site 869729011180 N-terminal domain interface [polypeptide binding]; other site 869729011181 putative substrate binding pocket (H-site) [chemical binding]; other site 869729011182 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 869729011183 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 869729011184 HlyD family secretion protein; Region: HlyD_3; pfam13437 869729011185 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 869729011186 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 869729011187 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 869729011188 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 869729011189 active site 869729011190 P-loop; other site 869729011191 phosphorylation site [posttranslational modification] 869729011192 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869729011193 active site 869729011194 phosphorylation site [posttranslational modification] 869729011195 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 869729011196 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 869729011197 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 869729011198 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 869729011199 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 869729011200 hypothetical protein; Provisional; Region: PRK11020 869729011201 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 869729011202 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 869729011203 trimer interface [polypeptide binding]; other site 869729011204 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 869729011205 trimer interface [polypeptide binding]; other site 869729011206 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 869729011207 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 869729011208 Haemagglutinin; Region: HIM; pfam05662 869729011209 Haemagglutinin; Region: HIM; pfam05662 869729011210 YadA-like C-terminal region; Region: YadA; pfam03895 869729011211 L-lactate permease; Provisional; Region: PRK10420 869729011212 glycolate transporter; Provisional; Region: PRK09695 869729011213 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 869729011214 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869729011215 DNA-binding site [nucleotide binding]; DNA binding site 869729011216 FCD domain; Region: FCD; pfam07729 869729011217 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 869729011218 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 869729011219 active site 869729011220 substrate binding site [chemical binding]; other site 869729011221 FMN binding site [chemical binding]; other site 869729011222 putative catalytic residues [active] 869729011223 putative rRNA methylase; Provisional; Region: PRK10358 869729011224 serine acetyltransferase; Provisional; Region: cysE; PRK11132 869729011225 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 869729011226 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 869729011227 trimer interface [polypeptide binding]; other site 869729011228 active site 869729011229 substrate binding site [chemical binding]; other site 869729011230 CoA binding site [chemical binding]; other site 869729011231 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 869729011232 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 869729011233 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 869729011234 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 869729011235 SecA binding site; other site 869729011236 Preprotein binding site; other site 869729011237 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 869729011238 GSH binding site [chemical binding]; other site 869729011239 catalytic residues [active] 869729011240 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 869729011241 active site residue [active] 869729011242 phosphoglyceromutase; Provisional; Region: PRK05434 869729011243 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 869729011244 AmiB activator; Provisional; Region: PRK11637 869729011245 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 869729011246 Peptidase family M23; Region: Peptidase_M23; pfam01551 869729011247 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 869729011248 NodB motif; other site 869729011249 putative active site [active] 869729011250 putative catalytic site [active] 869729011251 Zn binding site [ion binding]; other site 869729011252 putative glycosyl transferase; Provisional; Region: PRK10073 869729011253 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 869729011254 active site 869729011255 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 869729011256 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 869729011257 NAD(P) binding site [chemical binding]; other site 869729011258 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 869729011259 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 869729011260 substrate-cofactor binding pocket; other site 869729011261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729011262 catalytic residue [active] 869729011263 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 869729011264 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 869729011265 NADP binding site [chemical binding]; other site 869729011266 homopentamer interface [polypeptide binding]; other site 869729011267 substrate binding site [chemical binding]; other site 869729011268 active site 869729011269 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 869729011270 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 869729011271 putative active site [active] 869729011272 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 869729011273 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 869729011274 putative active site [active] 869729011275 O-Antigen ligase; Region: Wzy_C; pfam04932 869729011276 potential frameshift: common BLAST hit: gi|218560697|ref|YP_002393610.1| putative beta1,3-glucosyltransferase 869729011277 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 869729011278 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 869729011279 Ligand binding site; other site 869729011280 metal-binding site 869729011281 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 869729011282 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 869729011283 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 869729011284 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 869729011285 Ligand binding site; other site 869729011286 metal-binding site 869729011287 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 869729011288 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 869729011289 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 869729011290 Ligand binding site; other site 869729011291 metal-binding site 869729011292 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 869729011293 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 869729011294 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 869729011295 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869729011296 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 869729011297 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 869729011298 putative active site [active] 869729011299 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 869729011300 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 869729011301 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 869729011302 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 869729011303 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 869729011304 active site 869729011305 (T/H)XGH motif; other site 869729011306 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 869729011307 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 869729011308 DNA binding site [nucleotide binding] 869729011309 catalytic residue [active] 869729011310 H2TH interface [polypeptide binding]; other site 869729011311 putative catalytic residues [active] 869729011312 turnover-facilitating residue; other site 869729011313 intercalation triad [nucleotide binding]; other site 869729011314 8OG recognition residue [nucleotide binding]; other site 869729011315 putative reading head residues; other site 869729011316 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 869729011317 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 869729011318 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 869729011319 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 869729011320 hypothetical protein; Reviewed; Region: PRK00024 869729011321 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 869729011322 MPN+ (JAMM) motif; other site 869729011323 Zinc-binding site [ion binding]; other site 869729011324 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 869729011325 Flavoprotein; Region: Flavoprotein; pfam02441 869729011326 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 869729011327 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 869729011328 trimer interface [polypeptide binding]; other site 869729011329 active site 869729011330 division inhibitor protein; Provisional; Region: slmA; PRK09480 869729011331 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869729011332 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869729011333 active site 869729011334 ribonuclease PH; Reviewed; Region: rph; PRK00173 869729011335 Ribonuclease PH; Region: RNase_PH_bact; cd11362 869729011336 hexamer interface [polypeptide binding]; other site 869729011337 active site 869729011338 hypothetical protein; Provisional; Region: PRK11820 869729011339 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 869729011340 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 869729011341 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 869729011342 BRO family, N-terminal domain; Region: Bro-N; pfam02498 869729011343 Predicted membrane protein [Function unknown]; Region: COG2860 869729011344 UPF0126 domain; Region: UPF0126; pfam03458 869729011345 UPF0126 domain; Region: UPF0126; pfam03458 869729011346 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 869729011347 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 869729011348 nucleotide binding pocket [chemical binding]; other site 869729011349 K-X-D-G motif; other site 869729011350 catalytic site [active] 869729011351 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 869729011352 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 869729011353 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 869729011354 catalytic site [active] 869729011355 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 869729011356 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 869729011357 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869729011358 Zn2+ binding site [ion binding]; other site 869729011359 Mg2+ binding site [ion binding]; other site 869729011360 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 869729011361 synthetase active site [active] 869729011362 NTP binding site [chemical binding]; other site 869729011363 metal binding site [ion binding]; metal-binding site 869729011364 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 869729011365 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 869729011366 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 869729011367 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 869729011368 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 869729011369 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 869729011370 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 869729011371 generic binding surface II; other site 869729011372 ssDNA binding site; other site 869729011373 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869729011374 ATP binding site [chemical binding]; other site 869729011375 putative Mg++ binding site [ion binding]; other site 869729011376 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869729011377 nucleotide binding region [chemical binding]; other site 869729011378 ATP-binding site [chemical binding]; other site 869729011379 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 869729011380 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 869729011381 AsmA family; Region: AsmA; pfam05170 869729011382 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 869729011383 Protein of unknown function (DUF1498); Region: DUF1498; pfam07385 869729011384 fructokinase; Reviewed; Region: PRK09557 869729011385 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 869729011386 nucleotide binding site [chemical binding]; other site 869729011387 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 869729011388 intersubunit interface [polypeptide binding]; other site 869729011389 active site 869729011390 zinc binding site [ion binding]; other site 869729011391 Na+ binding site [ion binding]; other site 869729011392 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 869729011393 intersubunit interface [polypeptide binding]; other site 869729011394 active site 869729011395 zinc binding site [ion binding]; other site 869729011396 Na+ binding site [ion binding]; other site 869729011397 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 869729011398 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 869729011399 active site 869729011400 P-loop; other site 869729011401 phosphorylation site [posttranslational modification] 869729011402 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869729011403 active site 869729011404 phosphorylation site [posttranslational modification] 869729011405 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 869729011406 HTH domain; Region: HTH_11; pfam08279 869729011407 Mga helix-turn-helix domain; Region: Mga; pfam05043 869729011408 PRD domain; Region: PRD; pfam00874 869729011409 PRD domain; Region: PRD; pfam00874 869729011410 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 869729011411 active site 869729011412 P-loop; other site 869729011413 phosphorylation site [posttranslational modification] 869729011414 putative alpha-glucosidase; Provisional; Region: PRK10658 869729011415 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 869729011416 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 869729011417 active site 869729011418 homotrimer interface [polypeptide binding]; other site 869729011419 catalytic site [active] 869729011420 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 869729011421 putative transporter; Provisional; Region: PRK11462 869729011422 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 869729011423 Virulence protein [General function prediction only]; Region: COG3943 869729011424 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 869729011425 potential frameshift: common BLAST hit: gi|117625940|ref|YP_859263.1| putative inner membrane protein 869729011426 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 869729011427 lipoprotein, YaeC family; Region: TIGR00363 869729011428 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 869729011429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729011430 putative substrate translocation pore; other site 869729011431 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 869729011432 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 869729011433 cryptic adenine deaminase; Provisional; Region: PRK10027 869729011434 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 869729011435 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 869729011436 active site 869729011437 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 869729011438 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 869729011439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729011440 putative substrate translocation pore; other site 869729011441 regulatory protein UhpC; Provisional; Region: PRK11663 869729011442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729011443 putative substrate translocation pore; other site 869729011444 sensory histidine kinase UhpB; Provisional; Region: PRK11644 869729011445 MASE1; Region: MASE1; pfam05231 869729011446 Histidine kinase; Region: HisKA_3; pfam07730 869729011447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729011448 ATP binding site [chemical binding]; other site 869729011449 Mg2+ binding site [ion binding]; other site 869729011450 G-X-G motif; other site 869729011451 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 869729011452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729011453 active site 869729011454 phosphorylation site [posttranslational modification] 869729011455 intermolecular recognition site; other site 869729011456 dimerization interface [polypeptide binding]; other site 869729011457 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869729011458 DNA binding residues [nucleotide binding] 869729011459 dimerization interface [polypeptide binding]; other site 869729011460 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 869729011461 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 869729011462 putative valine binding site [chemical binding]; other site 869729011463 dimer interface [polypeptide binding]; other site 869729011464 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 869729011465 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 869729011466 PYR/PP interface [polypeptide binding]; other site 869729011467 dimer interface [polypeptide binding]; other site 869729011468 TPP binding site [chemical binding]; other site 869729011469 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 869729011470 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 869729011471 TPP-binding site [chemical binding]; other site 869729011472 dimer interface [polypeptide binding]; other site 869729011473 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 869729011474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729011475 putative substrate translocation pore; other site 869729011476 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 869729011477 Domain of unknown function (DUF202); Region: DUF202; pfam02656 869729011478 Predicted membrane protein [Function unknown]; Region: COG2149 869729011479 potential frameshift: common BLAST hit: gi|117625958|ref|YP_859281.1| sulfatase/phosphatase YidJ 869729011480 putative transporter; Provisional; Region: PRK10484 869729011481 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 869729011482 Na binding site [ion binding]; other site 869729011483 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 869729011484 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729011485 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 869729011486 putative transporter; Validated; Region: PRK03818 869729011487 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 869729011488 TrkA-C domain; Region: TrkA_C; pfam02080 869729011489 TrkA-C domain; Region: TrkA_C; pfam02080 869729011490 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 869729011491 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 869729011492 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 869729011493 putative dimer interface [polypeptide binding]; other site 869729011494 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 869729011495 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 869729011496 putative dimer interface [polypeptide binding]; other site 869729011497 hypothetical protein; Provisional; Region: PRK11616 869729011498 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 869729011499 putative oxidoreductase; Provisional; Region: PRK11445 869729011500 hypothetical protein; Provisional; Region: PRK07236 869729011501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729011502 D-galactonate transporter; Region: 2A0114; TIGR00893 869729011503 putative substrate translocation pore; other site 869729011504 galactonate dehydratase; Provisional; Region: PRK14017 869729011505 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 869729011506 putative active site pocket [active] 869729011507 putative metal binding site [ion binding]; other site 869729011508 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 869729011509 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 869729011510 active site 869729011511 intersubunit interface [polypeptide binding]; other site 869729011512 catalytic residue [active] 869729011513 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 869729011514 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 869729011515 Transcriptional regulators [Transcription]; Region: FadR; COG2186 869729011516 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869729011517 DNA-binding site [nucleotide binding]; DNA binding site 869729011518 FCD domain; Region: FCD; pfam07729 869729011519 hypothetical protein; Provisional; Region: PRK10215 869729011520 sugar phosphate phosphatase; Provisional; Region: PRK10513 869729011521 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869729011522 active site 869729011523 motif I; other site 869729011524 motif II; other site 869729011525 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869729011526 hypothetical protein; Provisional; Region: PRK11426 869729011527 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 869729011528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729011529 Mg2+ binding site [ion binding]; other site 869729011530 G-X-G motif; other site 869729011531 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 869729011532 anchoring element; other site 869729011533 dimer interface [polypeptide binding]; other site 869729011534 ATP binding site [chemical binding]; other site 869729011535 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 869729011536 active site 869729011537 putative metal-binding site [ion binding]; other site 869729011538 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 869729011539 recF protein; Region: recf; TIGR00611 869729011540 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869729011541 Walker A/P-loop; other site 869729011542 ATP binding site [chemical binding]; other site 869729011543 Q-loop/lid; other site 869729011544 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869729011545 ABC transporter signature motif; other site 869729011546 Walker B; other site 869729011547 D-loop; other site 869729011548 H-loop/switch region; other site 869729011549 DNA polymerase III subunit beta; Validated; Region: PRK05643 869729011550 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 869729011551 putative DNA binding surface [nucleotide binding]; other site 869729011552 dimer interface [polypeptide binding]; other site 869729011553 beta-clamp/clamp loader binding surface; other site 869729011554 beta-clamp/translesion DNA polymerase binding surface; other site 869729011555 DnaA N-terminal domain; Region: DnaA_N; pfam11638 869729011556 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 869729011557 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729011558 Walker A motif; other site 869729011559 ATP binding site [chemical binding]; other site 869729011560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 869729011561 Walker B motif; other site 869729011562 arginine finger; other site 869729011563 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 869729011564 DnaA box-binding interface [nucleotide binding]; other site 869729011565 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 869729011566 ribonuclease P; Reviewed; Region: rnpA; PRK01732 869729011567 hypothetical protein; Validated; Region: PRK00041 869729011568 membrane protein insertase; Provisional; Region: PRK01318 869729011569 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 869729011570 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 869729011571 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 869729011572 trmE is a tRNA modification GTPase; Region: trmE; cd04164 869729011573 G1 box; other site 869729011574 GTP/Mg2+ binding site [chemical binding]; other site 869729011575 Switch I region; other site 869729011576 G2 box; other site 869729011577 Switch II region; other site 869729011578 G3 box; other site 869729011579 G4 box; other site 869729011580 G5 box; other site 869729011581 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 869729011582 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 869729011583 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 869729011584 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869729011585 catalytic residue [active] 869729011586 tryptophan permease TnaB; Provisional; Region: PRK09664 869729011587 aromatic amino acid transport protein; Region: araaP; TIGR00837 869729011588 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 869729011589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729011590 putative substrate translocation pore; other site 869729011591 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 869729011592 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729011593 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 869729011594 substrate binding pocket [chemical binding]; other site 869729011595 dimerization interface [polypeptide binding]; other site 869729011596 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 869729011597 Predicted flavoprotein [General function prediction only]; Region: COG0431 869729011598 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 869729011599 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 869729011600 potential frameshift: common BLAST hit: gi|218692004|ref|YP_002400216.1| 6-phosphogluconate phosphatase 869729011601 putative inner membrane protein; Provisional; Region: PRK09823 869729011602 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 869729011603 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 869729011604 active site 869729011605 trimer interface [polypeptide binding]; other site 869729011606 allosteric site; other site 869729011607 active site lid [active] 869729011608 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 869729011609 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 869729011610 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 869729011611 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 869729011612 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 869729011613 trimer interface; other site 869729011614 sugar binding site [chemical binding]; other site 869729011615 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 869729011616 beta-galactosidase; Region: BGL; TIGR03356 869729011617 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 869729011618 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869729011619 active site turn [active] 869729011620 phosphorylation site [posttranslational modification] 869729011621 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869729011622 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 869729011623 HPr interaction site; other site 869729011624 glycerol kinase (GK) interaction site [polypeptide binding]; other site 869729011625 active site 869729011626 phosphorylation site [posttranslational modification] 869729011627 transcriptional antiterminator BglG; Provisional; Region: PRK09772 869729011628 CAT RNA binding domain; Region: CAT_RBD; pfam03123 869729011629 PRD domain; Region: PRD; pfam00874 869729011630 PRD domain; Region: PRD; pfam00874 869729011631 transcriptional regulator PhoU; Provisional; Region: PRK11115 869729011632 PhoU domain; Region: PhoU; pfam01895 869729011633 PhoU domain; Region: PhoU; pfam01895 869729011634 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 869729011635 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 869729011636 Walker A/P-loop; other site 869729011637 ATP binding site [chemical binding]; other site 869729011638 Q-loop/lid; other site 869729011639 ABC transporter signature motif; other site 869729011640 Walker B; other site 869729011641 D-loop; other site 869729011642 H-loop/switch region; other site 869729011643 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 869729011644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729011645 dimer interface [polypeptide binding]; other site 869729011646 conserved gate region; other site 869729011647 putative PBP binding loops; other site 869729011648 ABC-ATPase subunit interface; other site 869729011649 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 869729011650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729011651 dimer interface [polypeptide binding]; other site 869729011652 conserved gate region; other site 869729011653 putative PBP binding loops; other site 869729011654 ABC-ATPase subunit interface; other site 869729011655 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869729011656 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 869729011657 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 869729011658 glutaminase active site [active] 869729011659 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 869729011660 dimer interface [polypeptide binding]; other site 869729011661 active site 869729011662 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 869729011663 dimer interface [polypeptide binding]; other site 869729011664 active site 869729011665 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 869729011666 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 869729011667 Substrate binding site; other site 869729011668 Mg++ binding site; other site 869729011669 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 869729011670 active site 869729011671 substrate binding site [chemical binding]; other site 869729011672 CoA binding site [chemical binding]; other site 869729011673 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 869729011674 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 869729011675 gamma subunit interface [polypeptide binding]; other site 869729011676 epsilon subunit interface [polypeptide binding]; other site 869729011677 LBP interface [polypeptide binding]; other site 869729011678 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 869729011679 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 869729011680 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 869729011681 alpha subunit interaction interface [polypeptide binding]; other site 869729011682 Walker A motif; other site 869729011683 ATP binding site [chemical binding]; other site 869729011684 Walker B motif; other site 869729011685 inhibitor binding site; inhibition site 869729011686 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 869729011687 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 869729011688 core domain interface [polypeptide binding]; other site 869729011689 delta subunit interface [polypeptide binding]; other site 869729011690 epsilon subunit interface [polypeptide binding]; other site 869729011691 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 869729011692 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 869729011693 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 869729011694 beta subunit interaction interface [polypeptide binding]; other site 869729011695 Walker A motif; other site 869729011696 ATP binding site [chemical binding]; other site 869729011697 Walker B motif; other site 869729011698 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 869729011699 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 869729011700 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 869729011701 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 869729011702 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 869729011703 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 869729011704 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 869729011705 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 869729011706 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 869729011707 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 869729011708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729011709 S-adenosylmethionine binding site [chemical binding]; other site 869729011710 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 869729011711 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 869729011712 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 869729011713 FMN-binding protein MioC; Provisional; Region: PRK09004 869729011714 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 869729011715 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869729011716 putative DNA binding site [nucleotide binding]; other site 869729011717 putative Zn2+ binding site [ion binding]; other site 869729011718 AsnC family; Region: AsnC_trans_reg; pfam01037 869729011719 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 869729011720 dimer interface [polypeptide binding]; other site 869729011721 active site 869729011722 hypothetical protein; Provisional; Region: yieM; PRK10997 869729011723 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 869729011724 metal ion-dependent adhesion site (MIDAS); other site 869729011725 regulatory ATPase RavA; Provisional; Region: PRK13531 869729011726 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729011727 Walker A motif; other site 869729011728 ATP binding site [chemical binding]; other site 869729011729 Walker B motif; other site 869729011730 arginine finger; other site 869729011731 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 869729011732 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 869729011733 potassium uptake protein; Region: kup; TIGR00794 869729011734 D-ribose pyranase; Provisional; Region: PRK11797 869729011735 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 869729011736 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 869729011737 Walker A/P-loop; other site 869729011738 ATP binding site [chemical binding]; other site 869729011739 Q-loop/lid; other site 869729011740 ABC transporter signature motif; other site 869729011741 Walker B; other site 869729011742 D-loop; other site 869729011743 H-loop/switch region; other site 869729011744 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 869729011745 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869729011746 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 869729011747 TM-ABC transporter signature motif; other site 869729011748 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 869729011749 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 869729011750 ligand binding site [chemical binding]; other site 869729011751 dimerization interface [polypeptide binding]; other site 869729011752 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 869729011753 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 869729011754 substrate binding site [chemical binding]; other site 869729011755 dimer interface [polypeptide binding]; other site 869729011756 ATP binding site [chemical binding]; other site 869729011757 transcriptional repressor RbsR; Provisional; Region: PRK10423 869729011758 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869729011759 DNA binding site [nucleotide binding] 869729011760 domain linker motif; other site 869729011761 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 869729011762 dimerization interface [polypeptide binding]; other site 869729011763 ligand binding site [chemical binding]; other site 869729011764 putative transporter; Provisional; Region: PRK10504 869729011765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729011766 putative substrate translocation pore; other site 869729011767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729011768 Transcriptional regulators [Transcription]; Region: FadR; COG2186 869729011769 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869729011770 DNA-binding site [nucleotide binding]; DNA binding site 869729011771 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 869729011772 transcriptional regulator HdfR; Provisional; Region: PRK03601 869729011773 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729011774 LysR substrate binding domain; Region: LysR_substrate; pfam03466 869729011775 dimerization interface [polypeptide binding]; other site 869729011776 hypothetical protein; Provisional; Region: PRK11027 869729011777 putative ATP-dependent protease; Provisional; Region: PRK09862 869729011778 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 869729011779 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729011780 Walker A motif; other site 869729011781 ATP binding site [chemical binding]; other site 869729011782 Walker B motif; other site 869729011783 arginine finger; other site 869729011784 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 869729011785 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 869729011786 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 869729011787 PYR/PP interface [polypeptide binding]; other site 869729011788 dimer interface [polypeptide binding]; other site 869729011789 TPP binding site [chemical binding]; other site 869729011790 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 869729011791 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 869729011792 TPP-binding site [chemical binding]; other site 869729011793 dimer interface [polypeptide binding]; other site 869729011794 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 869729011795 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 869729011796 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 869729011797 homodimer interface [polypeptide binding]; other site 869729011798 substrate-cofactor binding pocket; other site 869729011799 catalytic residue [active] 869729011800 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 869729011801 threonine dehydratase; Reviewed; Region: PRK09224 869729011802 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 869729011803 tetramer interface [polypeptide binding]; other site 869729011804 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729011805 catalytic residue [active] 869729011806 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 869729011807 putative Ile/Val binding site [chemical binding]; other site 869729011808 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 869729011809 putative Ile/Val binding site [chemical binding]; other site 869729011810 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729011811 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 869729011812 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 869729011813 putative dimerization interface [polypeptide binding]; other site 869729011814 ketol-acid reductoisomerase; Validated; Region: PRK05225 869729011815 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 869729011816 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 869729011817 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 869729011818 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 869729011819 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 869729011820 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 869729011821 Part of AAA domain; Region: AAA_19; pfam13245 869729011822 Family description; Region: UvrD_C_2; pfam13538 869729011823 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 869729011824 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 869729011825 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 869729011826 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 869729011827 ATP binding site [chemical binding]; other site 869729011828 Mg++ binding site [ion binding]; other site 869729011829 motif III; other site 869729011830 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869729011831 nucleotide binding region [chemical binding]; other site 869729011832 ATP-binding site [chemical binding]; other site 869729011833 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 869729011834 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 869729011835 catalytic residues [active] 869729011836 putative rho operon leader peptide; Provisional; Region: PRK09979 869729011837 transcription termination factor Rho; Provisional; Region: rho; PRK09376 869729011838 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 869729011839 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 869729011840 RNA binding site [nucleotide binding]; other site 869729011841 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 869729011842 multimer interface [polypeptide binding]; other site 869729011843 Walker A motif; other site 869729011844 ATP binding site [chemical binding]; other site 869729011845 Walker B motif; other site 869729011846 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 869729011847 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 869729011848 Mg++ binding site [ion binding]; other site 869729011849 putative catalytic motif [active] 869729011850 substrate binding site [chemical binding]; other site 869729011851 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 869729011852 Chain length determinant protein; Region: Wzz; pfam02706 869729011853 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 869729011854 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 869729011855 active site 869729011856 homodimer interface [polypeptide binding]; other site 869729011857 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 869729011858 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 869729011859 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 869729011860 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 869729011861 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 869729011862 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 869729011863 NAD binding site [chemical binding]; other site 869729011864 substrate binding site [chemical binding]; other site 869729011865 homodimer interface [polypeptide binding]; other site 869729011866 active site 869729011867 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 869729011868 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 869729011869 substrate binding site; other site 869729011870 tetramer interface; other site 869729011871 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 869729011872 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 869729011873 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 869729011874 inhibitor-cofactor binding pocket; inhibition site 869729011875 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729011876 catalytic residue [active] 869729011877 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 869729011878 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 869729011879 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 869729011880 putative common antigen polymerase; Provisional; Region: PRK02975 869729011881 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 869729011882 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 869729011883 putative transport protein YifK; Provisional; Region: PRK10746 869729011884 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 869729011885 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869729011886 FeS/SAM binding site; other site 869729011887 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 869729011888 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 869729011889 Sulfatase; Region: Sulfatase; pfam00884 869729011890 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 869729011891 HemY protein N-terminus; Region: HemY_N; pfam07219 869729011892 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 869729011893 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 869729011894 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 869729011895 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 869729011896 active site 869729011897 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 869729011898 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 869729011899 domain interfaces; other site 869729011900 active site 869729011901 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 869729011902 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 869729011903 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 869729011904 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 869729011905 putative iron binding site [ion binding]; other site 869729011906 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 869729011907 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 869729011908 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 869729011909 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 869729011910 hypothetical protein; Provisional; Region: PRK10963 869729011911 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 869729011912 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 869729011913 active site 869729011914 DNA binding site [nucleotide binding] 869729011915 Int/Topo IB signature motif; other site 869729011916 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 869729011917 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869729011918 motif II; other site 869729011919 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 869729011920 Part of AAA domain; Region: AAA_19; pfam13245 869729011921 Family description; Region: UvrD_C_2; pfam13538 869729011922 Uncharacterized conserved protein [Function unknown]; Region: COG1912 869729011923 Predicted periplasmic protein [Function unknown]; Region: COG3698 869729011924 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 869729011925 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 869729011926 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 869729011927 Cl binding site [ion binding]; other site 869729011928 oligomer interface [polypeptide binding]; other site 869729011929 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 869729011930 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 869729011931 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 869729011932 EamA-like transporter family; Region: EamA; cl17759 869729011933 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 869729011934 CoenzymeA binding site [chemical binding]; other site 869729011935 subunit interaction site [polypeptide binding]; other site 869729011936 PHB binding site; other site 869729011937 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 869729011938 dimerization interface [polypeptide binding]; other site 869729011939 substrate binding site [chemical binding]; other site 869729011940 active site 869729011941 calcium binding site [ion binding]; other site 869729011942 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 869729011943 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869729011944 ATP binding site [chemical binding]; other site 869729011945 putative Mg++ binding site [ion binding]; other site 869729011946 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869729011947 nucleotide binding region [chemical binding]; other site 869729011948 ATP-binding site [chemical binding]; other site 869729011949 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 869729011950 Helicase and RNase D C-terminal; Region: HRDC; smart00341 869729011951 threonine efflux system; Provisional; Region: PRK10229 869729011952 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 869729011953 lysophospholipase L2; Provisional; Region: PRK10749 869729011954 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 869729011955 putative hydrolase; Provisional; Region: PRK10976 869729011956 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869729011957 active site 869729011958 motif I; other site 869729011959 motif II; other site 869729011960 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869729011961 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 869729011962 EamA-like transporter family; Region: EamA; pfam00892 869729011963 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 869729011964 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729011965 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 869729011966 putative dimerization interface [polypeptide binding]; other site 869729011967 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 869729011968 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 869729011969 THF binding site; other site 869729011970 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 869729011971 substrate binding site [chemical binding]; other site 869729011972 THF binding site; other site 869729011973 zinc-binding site [ion binding]; other site 869729011974 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 869729011975 tetramer interface [polypeptide binding]; other site 869729011976 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 869729011977 active site 869729011978 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 869729011979 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869729011980 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869729011981 active site turn [active] 869729011982 phosphorylation site [posttranslational modification] 869729011983 transketolase; Reviewed; Region: PRK12753 869729011984 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 869729011985 TPP-binding site [chemical binding]; other site 869729011986 dimer interface [polypeptide binding]; other site 869729011987 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 869729011988 PYR/PP interface [polypeptide binding]; other site 869729011989 dimer interface [polypeptide binding]; other site 869729011990 TPP binding site [chemical binding]; other site 869729011991 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869729011992 potential frameshift: common BLAST hit: gi|215489162|ref|YP_002331593.1| predicted transcriptional regulator, RpiR family 869729011993 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 869729011994 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729011995 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 869729011996 dimerization interface [polypeptide binding]; other site 869729011997 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 869729011998 Na binding site [ion binding]; other site 869729011999 allophanate hydrolase; Provisional; Region: PRK08186 869729012000 carbamate kinase; Reviewed; Region: PRK12686 869729012001 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 869729012002 putative substrate binding site [chemical binding]; other site 869729012003 nucleotide binding site [chemical binding]; other site 869729012004 nucleotide binding site [chemical binding]; other site 869729012005 homodimer interface [polypeptide binding]; other site 869729012006 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 869729012007 CoA binding domain; Region: CoA_binding; pfam02629 869729012008 CoA-ligase; Region: Ligase_CoA; pfam00549 869729012009 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 869729012010 Isochorismatase family; Region: Isochorismatase; pfam00857 869729012011 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 869729012012 catalytic triad [active] 869729012013 conserved cis-peptide bond; other site 869729012014 Dienelactone hydrolase family; Region: DLH; pfam01738 869729012015 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 869729012016 uridine phosphorylase; Provisional; Region: PRK11178 869729012017 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 869729012018 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 869729012019 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 869729012020 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 869729012021 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 869729012022 active site 869729012023 intersubunit interface [polypeptide binding]; other site 869729012024 catalytic residue [active] 869729012025 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 869729012026 Transcriptional regulator [Transcription]; Region: IclR; COG1414 869729012027 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 869729012028 Bacterial transcriptional regulator; Region: IclR; pfam01614 869729012029 DNA recombination protein RmuC; Provisional; Region: PRK10361 869729012030 RmuC family; Region: RmuC; pfam02646 869729012031 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 869729012032 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729012033 S-adenosylmethionine binding site [chemical binding]; other site 869729012034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 869729012035 SCP-2 sterol transfer family; Region: SCP2; pfam02036 869729012036 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 869729012037 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 869729012038 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 869729012039 sec-independent translocase; Provisional; Region: PRK01770 869729012040 sec-independent translocase; Provisional; Region: tatB; PRK00404 869729012041 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 869729012042 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 869729012043 active site 869729012044 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 869729012045 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 869729012046 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 869729012047 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 869729012048 FMN reductase; Validated; Region: fre; PRK08051 869729012049 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 869729012050 FAD binding pocket [chemical binding]; other site 869729012051 FAD binding motif [chemical binding]; other site 869729012052 phosphate binding motif [ion binding]; other site 869729012053 beta-alpha-beta structure motif; other site 869729012054 NAD binding pocket [chemical binding]; other site 869729012055 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 869729012056 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 869729012057 dimer interface [polypeptide binding]; other site 869729012058 active site 869729012059 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 869729012060 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 869729012061 substrate binding site [chemical binding]; other site 869729012062 oxyanion hole (OAH) forming residues; other site 869729012063 trimer interface [polypeptide binding]; other site 869729012064 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 869729012065 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 869729012066 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 869729012067 proline dipeptidase; Provisional; Region: PRK13607 869729012068 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 869729012069 active site 869729012070 hypothetical protein; Provisional; Region: PRK11568 869729012071 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 869729012072 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 869729012073 potassium transporter; Provisional; Region: PRK10750 869729012074 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 869729012075 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 869729012076 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 869729012077 Walker A motif; other site 869729012078 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 869729012079 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 869729012080 GTP binding site; other site 869729012081 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 869729012082 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 869729012083 serine/threonine protein kinase; Provisional; Region: PRK11768 869729012084 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 869729012085 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 869729012086 catalytic residues [active] 869729012087 hinge region; other site 869729012088 alpha helical domain; other site 869729012089 hypothetical protein; Provisional; Region: PRK11367 869729012090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 869729012091 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 869729012092 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 869729012093 putative acyl-acceptor binding pocket; other site 869729012094 DNA polymerase I; Provisional; Region: PRK05755 869729012095 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 869729012096 active site 869729012097 metal binding site 1 [ion binding]; metal-binding site 869729012098 putative 5' ssDNA interaction site; other site 869729012099 metal binding site 3; metal-binding site 869729012100 metal binding site 2 [ion binding]; metal-binding site 869729012101 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 869729012102 putative DNA binding site [nucleotide binding]; other site 869729012103 putative metal binding site [ion binding]; other site 869729012104 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 869729012105 active site 869729012106 catalytic site [active] 869729012107 substrate binding site [chemical binding]; other site 869729012108 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 869729012109 active site 869729012110 DNA binding site [nucleotide binding] 869729012111 catalytic site [active] 869729012112 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 869729012113 G1 box; other site 869729012114 GTP/Mg2+ binding site [chemical binding]; other site 869729012115 Switch I region; other site 869729012116 G2 box; other site 869729012117 G3 box; other site 869729012118 Switch II region; other site 869729012119 G4 box; other site 869729012120 G5 box; other site 869729012121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 869729012122 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 869729012123 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869729012124 FeS/SAM binding site; other site 869729012125 HemN C-terminal domain; Region: HemN_C; pfam06969 869729012126 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 869729012127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729012128 active site 869729012129 phosphorylation site [posttranslational modification] 869729012130 intermolecular recognition site; other site 869729012131 dimerization interface [polypeptide binding]; other site 869729012132 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729012133 Walker A motif; other site 869729012134 ATP binding site [chemical binding]; other site 869729012135 Walker B motif; other site 869729012136 arginine finger; other site 869729012137 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 869729012138 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 869729012139 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869729012140 putative active site [active] 869729012141 heme pocket [chemical binding]; other site 869729012142 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869729012143 dimer interface [polypeptide binding]; other site 869729012144 phosphorylation site [posttranslational modification] 869729012145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729012146 ATP binding site [chemical binding]; other site 869729012147 Mg2+ binding site [ion binding]; other site 869729012148 G-X-G motif; other site 869729012149 glutamine synthetase; Provisional; Region: glnA; PRK09469 869729012150 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 869729012151 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 869729012152 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 869729012153 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 869729012154 G1 box; other site 869729012155 putative GEF interaction site [polypeptide binding]; other site 869729012156 GTP/Mg2+ binding site [chemical binding]; other site 869729012157 Switch I region; other site 869729012158 G2 box; other site 869729012159 G3 box; other site 869729012160 Switch II region; other site 869729012161 G4 box; other site 869729012162 G5 box; other site 869729012163 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 869729012164 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 869729012165 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 869729012166 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 869729012167 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869729012168 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 869729012169 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 869729012170 substrate binding site [chemical binding]; other site 869729012171 ATP binding site [chemical binding]; other site 869729012172 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 869729012173 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 869729012174 Class I aldolases; Region: Aldolase_Class_I; cl17187 869729012175 catalytic residue [active] 869729012176 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 869729012177 putative oxidoreductase; Provisional; Region: PRK10083 869729012178 NAD(P) binding site [chemical binding]; other site 869729012179 benzoate transport; Region: 2A0115; TIGR00895 869729012180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729012181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729012182 shikimate transporter; Provisional; Region: PRK09952 869729012183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729012184 putative substrate translocation pore; other site 869729012185 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 869729012186 active site 869729012187 catalytic residues [active] 869729012188 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 869729012189 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869729012190 motif II; other site 869729012191 hypothetical protein; Reviewed; Region: PRK01637 869729012192 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 869729012193 putative active site [active] 869729012194 dimerization interface [polypeptide binding]; other site 869729012195 putative tRNAtyr binding site [nucleotide binding]; other site 869729012196 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869729012197 Coenzyme A binding pocket [chemical binding]; other site 869729012198 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 869729012199 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 869729012200 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 869729012201 substrate binding pocket [chemical binding]; other site 869729012202 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869729012203 non-specific DNA binding site [nucleotide binding]; other site 869729012204 salt bridge; other site 869729012205 sequence-specific DNA binding site [nucleotide binding]; other site 869729012206 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 869729012207 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 869729012208 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 869729012209 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 869729012210 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 869729012211 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 869729012212 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 869729012213 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 869729012214 molybdopterin cofactor binding site; other site 869729012215 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 869729012216 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 869729012217 molybdopterin cofactor binding site; other site 869729012218 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 869729012219 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 869729012220 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 869729012221 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 869729012222 intersubunit interface [polypeptide binding]; other site 869729012223 active site 869729012224 Zn2+ binding site [ion binding]; other site 869729012225 L-rhamnose isomerase; Provisional; Region: PRK01076 869729012226 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 869729012227 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 869729012228 N- and C-terminal domain interface [polypeptide binding]; other site 869729012229 active site 869729012230 putative catalytic site [active] 869729012231 metal binding site [ion binding]; metal-binding site 869729012232 ATP binding site [chemical binding]; other site 869729012233 rhamnulokinase; Provisional; Region: rhaB; PRK10640 869729012234 carbohydrate binding site [chemical binding]; other site 869729012235 transcriptional activator RhaS; Provisional; Region: PRK13503 869729012236 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 869729012237 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729012238 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729012239 transcriptional activator RhaR; Provisional; Region: PRK13500 869729012240 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 869729012241 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729012242 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729012243 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 869729012244 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 869729012245 superoxide dismutase; Provisional; Region: PRK10925 869729012246 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 869729012247 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 869729012248 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 869729012249 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 869729012250 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 869729012251 MOSC domain; Region: MOSC; pfam03473 869729012252 3-alpha domain; Region: 3-alpha; pfam03475 869729012253 two-component sensor protein; Provisional; Region: cpxA; PRK09470 869729012254 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869729012255 dimerization interface [polypeptide binding]; other site 869729012256 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869729012257 dimer interface [polypeptide binding]; other site 869729012258 phosphorylation site [posttranslational modification] 869729012259 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729012260 ATP binding site [chemical binding]; other site 869729012261 Mg2+ binding site [ion binding]; other site 869729012262 G-X-G motif; other site 869729012263 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 869729012264 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729012265 active site 869729012266 intermolecular recognition site; other site 869729012267 dimerization interface [polypeptide binding]; other site 869729012268 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869729012269 DNA binding site [nucleotide binding] 869729012270 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 869729012271 dimer interface [polypeptide binding]; other site 869729012272 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 869729012273 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 869729012274 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 869729012275 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 869729012276 active site 869729012277 ADP/pyrophosphate binding site [chemical binding]; other site 869729012278 dimerization interface [polypeptide binding]; other site 869729012279 allosteric effector site; other site 869729012280 fructose-1,6-bisphosphate binding site; other site 869729012281 sulfate transporter subunit; Provisional; Region: PRK10752 869729012282 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 869729012283 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 869729012284 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 869729012285 triosephosphate isomerase; Provisional; Region: PRK14567 869729012286 substrate binding site [chemical binding]; other site 869729012287 dimer interface [polypeptide binding]; other site 869729012288 catalytic triad [active] 869729012289 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 869729012290 Predicted membrane protein [Function unknown]; Region: COG3152 869729012291 hypothetical protein; Provisional; Region: PRK09981 869729012292 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 869729012293 Ligand Binding Site [chemical binding]; other site 869729012294 ferredoxin-NADP reductase; Provisional; Region: PRK10926 869729012295 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 869729012296 FAD binding pocket [chemical binding]; other site 869729012297 FAD binding motif [chemical binding]; other site 869729012298 phosphate binding motif [ion binding]; other site 869729012299 beta-alpha-beta structure motif; other site 869729012300 NAD binding pocket [chemical binding]; other site 869729012301 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 869729012302 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 869729012303 putative active site [active] 869729012304 glycerol kinase; Provisional; Region: glpK; PRK00047 869729012305 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 869729012306 N- and C-terminal domain interface [polypeptide binding]; other site 869729012307 homotetramer interface [polypeptide binding]; other site 869729012308 homodimer interface [polypeptide binding]; other site 869729012309 active site 869729012310 glycerol binding site [chemical binding]; other site 869729012311 FBP binding site [chemical binding]; other site 869729012312 MgATP binding site [chemical binding]; other site 869729012313 protein IIAGlc interface [polypeptide binding]; other site 869729012314 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 869729012315 amphipathic channel; other site 869729012316 Asn-Pro-Ala signature motifs; other site 869729012317 Protein of unknown function (DUF904); Region: DUF904; pfam06005 869729012318 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 869729012319 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 869729012320 UbiA prenyltransferase family; Region: UbiA; pfam01040 869729012321 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 869729012322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729012323 Walker A motif; other site 869729012324 ATP binding site [chemical binding]; other site 869729012325 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 869729012326 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 869729012327 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 869729012328 active site 869729012329 HslU subunit interaction site [polypeptide binding]; other site 869729012330 essential cell division protein FtsN; Provisional; Region: PRK10927 869729012331 cell division protein FtsN; Provisional; Region: PRK12757 869729012332 potential frameshift: common BLAST hit: gi|291285349|ref|YP_003502167.1| Transcriptional regulator 869729012333 primosome assembly protein PriA; Validated; Region: PRK05580 869729012334 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869729012335 ATP binding site [chemical binding]; other site 869729012336 putative Mg++ binding site [ion binding]; other site 869729012337 helicase superfamily c-terminal domain; Region: HELICc; smart00490 869729012338 ATP-binding site [chemical binding]; other site 869729012339 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 869729012340 hypothetical protein; Provisional; Region: PRK10030 869729012341 transcriptional repressor protein MetJ; Provisional; Region: PRK05264 869729012342 corepressor binding sites; other site 869729012343 cystathionine gamma-synthase; Provisional; Region: PRK08045 869729012344 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 869729012345 homodimer interface [polypeptide binding]; other site 869729012346 substrate-cofactor binding pocket; other site 869729012347 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729012348 catalytic residue [active] 869729012349 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 869729012350 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 869729012351 putative catalytic residues [active] 869729012352 putative nucleotide binding site [chemical binding]; other site 869729012353 putative aspartate binding site [chemical binding]; other site 869729012354 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 869729012355 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 869729012356 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 869729012357 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 869729012358 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 869729012359 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 869729012360 active site 869729012361 metal binding site [ion binding]; metal-binding site 869729012362 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 869729012363 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 869729012364 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 869729012365 active site 869729012366 metal binding site [ion binding]; metal-binding site 869729012367 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 869729012368 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 869729012369 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 869729012370 active site 869729012371 metal binding site [ion binding]; metal-binding site 869729012372 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 869729012373 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 869729012374 FAD binding site [chemical binding]; other site 869729012375 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 869729012376 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 869729012377 heme binding site [chemical binding]; other site 869729012378 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 869729012379 EamA-like transporter family; Region: EamA; pfam00892 869729012380 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 869729012381 EamA-like transporter family; Region: EamA; pfam00892 869729012382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 869729012383 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 869729012384 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 869729012385 dimer interface [polypeptide binding]; other site 869729012386 active site 869729012387 metal binding site [ion binding]; metal-binding site 869729012388 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 869729012389 active site 869729012390 intersubunit interactions; other site 869729012391 catalytic residue [active] 869729012392 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 869729012393 dimerization domain swap beta strand [polypeptide binding]; other site 869729012394 regulatory protein interface [polypeptide binding]; other site 869729012395 active site 869729012396 regulatory phosphorylation site [posttranslational modification]; other site 869729012397 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 869729012398 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 869729012399 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 869729012400 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 869729012401 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869729012402 active site 869729012403 phosphorylation site [posttranslational modification] 869729012404 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 869729012405 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 869729012406 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 869729012407 active site 869729012408 P-loop; other site 869729012409 phosphorylation site [posttranslational modification] 869729012410 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 869729012411 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 869729012412 dimer interface [polypeptide binding]; other site 869729012413 active site 869729012414 glycine loop; other site 869729012415 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 869729012416 FeS/SAM binding site; other site 869729012417 pyruvate formate lyase II activase; Provisional; Region: PRK10076 869729012418 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 869729012419 active site 869729012420 P-loop; other site 869729012421 phosphorylation site [posttranslational modification] 869729012422 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 869729012423 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729012424 hypothetical protein; Provisional; Region: PRK10649 869729012425 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 869729012426 Sulfatase; Region: Sulfatase; pfam00884 869729012427 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 869729012428 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 869729012429 acetylornithine deacetylase; Provisional; Region: PRK05111 869729012430 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 869729012431 metal binding site [ion binding]; metal-binding site 869729012432 putative dimer interface [polypeptide binding]; other site 869729012433 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 869729012434 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 869729012435 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 869729012436 nucleotide binding site [chemical binding]; other site 869729012437 N-acetyl-L-glutamate binding site [chemical binding]; other site 869729012438 argininosuccinate lyase; Provisional; Region: PRK04833 869729012439 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 869729012440 active sites [active] 869729012441 tetramer interface [polypeptide binding]; other site 869729012442 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 869729012443 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 869729012444 putative active site pocket [active] 869729012445 putative metal binding site [ion binding]; other site 869729012446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729012447 D-galactonate transporter; Region: 2A0114; TIGR00893 869729012448 putative substrate translocation pore; other site 869729012449 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 869729012450 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729012451 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 869729012452 dimerization interface [polypeptide binding]; other site 869729012453 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 869729012454 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869729012455 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 869729012456 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 869729012457 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 869729012458 metal binding site [ion binding]; metal-binding site 869729012459 putative dimer interface [polypeptide binding]; other site 869729012460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729012461 metabolite-proton symporter; Region: 2A0106; TIGR00883 869729012462 putative substrate translocation pore; other site 869729012463 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 869729012464 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869729012465 hypothetical protein; Provisional; Region: PRK11056 869729012466 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 869729012467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729012468 S-adenosylmethionine binding site [chemical binding]; other site 869729012469 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 869729012470 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 869729012471 N-terminal plug; other site 869729012472 ligand-binding site [chemical binding]; other site 869729012473 glutamate racemase; Provisional; Region: PRK00865 869729012474 hypothetical protein; Provisional; Region: PRK10039 869729012475 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 869729012476 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869729012477 Coenzyme A binding pocket [chemical binding]; other site 869729012478 homoserine O-succinyltransferase; Provisional; Region: PRK05368 869729012479 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 869729012480 proposed active site lysine [active] 869729012481 conserved cys residue [active] 869729012482 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 869729012483 malate synthase A; Region: malate_syn_A; TIGR01344 869729012484 active site 869729012485 isocitrate lyase; Provisional; Region: PRK15063 869729012486 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 869729012487 tetramer interface [polypeptide binding]; other site 869729012488 active site 869729012489 Mg2+/Mn2+ binding site [ion binding]; other site 869729012490 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 869729012491 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 869729012492 transcriptional repressor IclR; Provisional; Region: PRK11569 869729012493 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 869729012494 Bacterial transcriptional regulator; Region: IclR; pfam01614 869729012495 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 869729012496 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 869729012497 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 869729012498 substrate binding pocket [chemical binding]; other site 869729012499 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 869729012500 B12 binding site [chemical binding]; other site 869729012501 cobalt ligand [ion binding]; other site 869729012502 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 869729012503 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 869729012504 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 869729012505 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 869729012506 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 869729012507 active site pocket [active] 869729012508 oxyanion hole [active] 869729012509 catalytic triad [active] 869729012510 active site nucleophile [active] 869729012511 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 869729012512 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 869729012513 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 869729012514 putative NAD(P) binding site [chemical binding]; other site 869729012515 catalytic Zn binding site [ion binding]; other site 869729012516 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 869729012517 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 869729012518 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 869729012519 active site 869729012520 phosphorylation site [posttranslational modification] 869729012521 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 869729012522 active pocket/dimerization site; other site 869729012523 active site 869729012524 phosphorylation site [posttranslational modification] 869729012525 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 869729012526 classical (c) SDRs; Region: SDR_c; cd05233 869729012527 NAD(P) binding site [chemical binding]; other site 869729012528 active site 869729012529 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 869729012530 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869729012531 putative DNA binding site [nucleotide binding]; other site 869729012532 putative Zn2+ binding site [ion binding]; other site 869729012533 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 869729012534 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 869729012535 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869729012536 RNA binding surface [nucleotide binding]; other site 869729012537 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 869729012538 probable active site [active] 869729012539 hypothetical protein; Provisional; Region: PRK10515 869729012540 aspartate kinase III; Validated; Region: PRK09084 869729012541 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 869729012542 nucleotide binding site [chemical binding]; other site 869729012543 substrate binding site [chemical binding]; other site 869729012544 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 869729012545 lysine allosteric regulatory site; other site 869729012546 dimer interface [polypeptide binding]; other site 869729012547 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 869729012548 dimer interface [polypeptide binding]; other site 869729012549 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 869729012550 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 869729012551 active site 869729012552 dimer interface [polypeptide binding]; other site 869729012553 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 869729012554 dimer interface [polypeptide binding]; other site 869729012555 active site 869729012556 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 869729012557 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 869729012558 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 869729012559 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 869729012560 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869729012561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729012562 dimer interface [polypeptide binding]; other site 869729012563 conserved gate region; other site 869729012564 putative PBP binding loops; other site 869729012565 ABC-ATPase subunit interface; other site 869729012566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729012567 dimer interface [polypeptide binding]; other site 869729012568 conserved gate region; other site 869729012569 putative PBP binding loops; other site 869729012570 ABC-ATPase subunit interface; other site 869729012571 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 869729012572 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 869729012573 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869729012574 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 869729012575 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 869729012576 Walker A/P-loop; other site 869729012577 ATP binding site [chemical binding]; other site 869729012578 Q-loop/lid; other site 869729012579 ABC transporter signature motif; other site 869729012580 Walker B; other site 869729012581 D-loop; other site 869729012582 H-loop/switch region; other site 869729012583 TOBE domain; Region: TOBE_2; pfam08402 869729012584 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 869729012585 trimer interface; other site 869729012586 sugar binding site [chemical binding]; other site 869729012587 maltose regulon periplasmic protein; Provisional; Region: PRK10564 869729012588 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 869729012589 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 869729012590 UbiA prenyltransferase family; Region: UbiA; pfam01040 869729012591 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 869729012592 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 869729012593 putative acyl-acceptor binding pocket; other site 869729012594 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 869729012595 LexA repressor; Validated; Region: PRK00215 869729012596 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 869729012597 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 869729012598 Catalytic site [active] 869729012599 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 869729012600 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 869729012601 hypothetical protein; Provisional; Region: PRK10428 869729012602 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 869729012603 metal binding site 2 [ion binding]; metal-binding site 869729012604 putative DNA binding helix; other site 869729012605 metal binding site 1 [ion binding]; metal-binding site 869729012606 dimer interface [polypeptide binding]; other site 869729012607 structural Zn2+ binding site [ion binding]; other site 869729012608 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 869729012609 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 869729012610 FMN binding site [chemical binding]; other site 869729012611 active site 869729012612 catalytic residues [active] 869729012613 substrate binding site [chemical binding]; other site 869729012614 phage shock protein G; Reviewed; Region: pspG; PRK09459 869729012615 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 869729012616 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 869729012617 NADP binding site [chemical binding]; other site 869729012618 dimer interface [polypeptide binding]; other site 869729012619 L-aspartate oxidase; Provisional; Region: PRK06175 869729012620 FAD binding domain; Region: FAD_binding_2; pfam00890 869729012621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729012622 metabolite-proton symporter; Region: 2A0106; TIGR00883 869729012623 putative substrate translocation pore; other site 869729012624 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 869729012625 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 869729012626 substrate binding site [chemical binding]; other site 869729012627 oxyanion hole (OAH) forming residues; other site 869729012628 trimer interface [polypeptide binding]; other site 869729012629 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 869729012630 Coenzyme A transferase; Region: CoA_trans; smart00882 869729012631 Coenzyme A transferase; Region: CoA_trans; cl17247 869729012632 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869729012633 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869729012634 DNA binding site [nucleotide binding] 869729012635 domain linker motif; other site 869729012636 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 869729012637 putative dimerization interface [polypeptide binding]; other site 869729012638 putative ligand binding site [chemical binding]; other site 869729012639 replicative DNA helicase; Provisional; Region: PRK08006 869729012640 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 869729012641 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 869729012642 Walker A motif; other site 869729012643 ATP binding site [chemical binding]; other site 869729012644 Walker B motif; other site 869729012645 DNA binding loops [nucleotide binding] 869729012646 alanine racemase; Reviewed; Region: alr; PRK00053 869729012647 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 869729012648 active site 869729012649 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869729012650 substrate binding site [chemical binding]; other site 869729012651 catalytic residues [active] 869729012652 dimer interface [polypeptide binding]; other site 869729012653 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 869729012654 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 869729012655 active site 869729012656 nucleotide binding site [chemical binding]; other site 869729012657 HIGH motif; other site 869729012658 KMSKS motif; other site 869729012659 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 869729012660 AAA domain; Region: AAA_28; pfam13521 869729012661 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 869729012662 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869729012663 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729012664 homodimer interface [polypeptide binding]; other site 869729012665 catalytic residue [active] 869729012666 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 869729012667 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 869729012668 TPP-binding site [chemical binding]; other site 869729012669 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 869729012670 dimer interface [polypeptide binding]; other site 869729012671 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 869729012672 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 869729012673 E3 interaction surface; other site 869729012674 lipoyl attachment site [posttranslational modification]; other site 869729012675 e3 binding domain; Region: E3_binding; pfam02817 869729012676 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 869729012677 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 869729012678 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 869729012679 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869729012680 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 869729012681 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 869729012682 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 869729012683 CoA-ligase; Region: Ligase_CoA; pfam00549 869729012684 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 869729012685 CoA binding domain; Region: CoA_binding; smart00881 869729012686 CoA-ligase; Region: Ligase_CoA; pfam00549 869729012687 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 869729012688 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 869729012689 transmembrane helices; other site 869729012690 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 869729012691 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 869729012692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729012693 active site 869729012694 phosphorylation site [posttranslational modification] 869729012695 intermolecular recognition site; other site 869729012696 dimerization interface [polypeptide binding]; other site 869729012697 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729012698 Walker A motif; other site 869729012699 ATP binding site [chemical binding]; other site 869729012700 Walker B motif; other site 869729012701 arginine finger; other site 869729012702 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 869729012703 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 869729012704 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869729012705 dimer interface [polypeptide binding]; other site 869729012706 phosphorylation site [posttranslational modification] 869729012707 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729012708 ATP binding site [chemical binding]; other site 869729012709 Mg2+ binding site [ion binding]; other site 869729012710 G-X-G motif; other site 869729012711 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869729012712 active site 869729012713 motif I; other site 869729012714 motif II; other site 869729012715 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 869729012716 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 869729012717 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 869729012718 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 869729012719 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 869729012720 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 869729012721 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 869729012722 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 869729012723 dimer interface [polypeptide binding]; other site 869729012724 ssDNA binding site [nucleotide binding]; other site 869729012725 tetramer (dimer of dimers) interface [polypeptide binding]; other site 869729012726 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 869729012727 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 869729012728 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 869729012729 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 869729012730 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 869729012731 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729012732 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 869729012733 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 869729012734 DNA binding residues [nucleotide binding] 869729012735 dimer interface [polypeptide binding]; other site 869729012736 [2Fe-2S] cluster binding site [ion binding]; other site 869729012737 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 869729012738 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 869729012739 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 869729012740 Transcriptional regulator [Transcription]; Region: LysR; COG0583 869729012741 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729012742 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 869729012743 putative dimerization interface [polypeptide binding]; other site 869729012744 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 869729012745 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 869729012746 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 869729012747 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 869729012748 Na binding site [ion binding]; other site 869729012749 Predicted membrane protein [Function unknown]; Region: COG3162 869729012750 acetyl-CoA synthetase; Provisional; Region: PRK00174 869729012751 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 869729012752 active site 869729012753 CoA binding site [chemical binding]; other site 869729012754 acyl-activating enzyme (AAE) consensus motif; other site 869729012755 AMP binding site [chemical binding]; other site 869729012756 acetate binding site [chemical binding]; other site 869729012757 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 869729012758 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 869729012759 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 869729012760 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 869729012761 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 869729012762 heme lyase subunit NrfE; Provisional; Region: PRK10369 869729012763 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 869729012764 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 869729012765 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869729012766 binding surface 869729012767 TPR motif; other site 869729012768 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 869729012769 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 869729012770 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 869729012771 Sel1-like repeats; Region: SEL1; smart00671 869729012772 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 869729012773 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869729012774 Walker A/P-loop; other site 869729012775 ATP binding site [chemical binding]; other site 869729012776 Q-loop/lid; other site 869729012777 ABC transporter signature motif; other site 869729012778 Walker B; other site 869729012779 D-loop; other site 869729012780 H-loop/switch region; other site 869729012781 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 869729012782 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869729012783 Walker A/P-loop; other site 869729012784 ATP binding site [chemical binding]; other site 869729012785 Q-loop/lid; other site 869729012786 ABC transporter signature motif; other site 869729012787 Walker B; other site 869729012788 D-loop; other site 869729012789 H-loop/switch region; other site 869729012790 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 869729012791 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 869729012792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729012793 dimer interface [polypeptide binding]; other site 869729012794 conserved gate region; other site 869729012795 ABC-ATPase subunit interface; other site 869729012796 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 869729012797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729012798 dimer interface [polypeptide binding]; other site 869729012799 conserved gate region; other site 869729012800 putative PBP binding loops; other site 869729012801 ABC-ATPase subunit interface; other site 869729012802 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 869729012803 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 869729012804 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 869729012805 molybdopterin cofactor binding site; other site 869729012806 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 869729012807 molybdopterin cofactor binding site; other site 869729012808 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 869729012809 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 869729012810 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 869729012811 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 869729012812 multidrug resistance protein MdtN; Provisional; Region: PRK10476 869729012813 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 869729012814 HlyD family secretion protein; Region: HlyD_3; pfam13437 869729012815 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 869729012816 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 869729012817 D-allose kinase; Provisional; Region: PRK09698 869729012818 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 869729012819 nucleotide binding site [chemical binding]; other site 869729012820 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 869729012821 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 869729012822 substrate binding site [chemical binding]; other site 869729012823 hexamer interface [polypeptide binding]; other site 869729012824 metal binding site [ion binding]; metal-binding site 869729012825 potential frameshift: common BLAST hit: gi|260846881|ref|YP_003224659.1| D-allose transporter subunit 869729012826 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 869729012827 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869729012828 Walker A/P-loop; other site 869729012829 ATP binding site [chemical binding]; other site 869729012830 Q-loop/lid; other site 869729012831 ABC transporter signature motif; other site 869729012832 Walker B; other site 869729012833 D-loop; other site 869729012834 H-loop/switch region; other site 869729012835 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 869729012836 D-allose transporter subunit; Provisional; Region: PRK09701 869729012837 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 869729012838 ligand binding site [chemical binding]; other site 869729012839 dimerization interface [polypeptide binding]; other site 869729012840 zinc binding site [ion binding]; other site 869729012841 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 869729012842 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 869729012843 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 869729012844 putative active site [active] 869729012845 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 869729012846 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 869729012847 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869729012848 Coenzyme A binding pocket [chemical binding]; other site 869729012849 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 869729012850 AAA domain; Region: AAA_18; pfam13238 869729012851 active site 869729012852 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 869729012853 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 869729012854 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 869729012855 active site 869729012856 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 869729012857 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869729012858 Walker A/P-loop; other site 869729012859 ATP binding site [chemical binding]; other site 869729012860 Q-loop/lid; other site 869729012861 ABC transporter signature motif; other site 869729012862 Walker B; other site 869729012863 D-loop; other site 869729012864 H-loop/switch region; other site 869729012865 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 869729012866 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869729012867 Walker A/P-loop; other site 869729012868 ATP binding site [chemical binding]; other site 869729012869 Q-loop/lid; other site 869729012870 ABC transporter signature motif; other site 869729012871 Walker B; other site 869729012872 D-loop; other site 869729012873 H-loop/switch region; other site 869729012874 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 869729012875 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 869729012876 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 869729012877 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 869729012878 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 869729012879 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 869729012880 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869729012881 DNA-binding site [nucleotide binding]; DNA binding site 869729012882 UTRA domain; Region: UTRA; pfam07702 869729012883 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 869729012884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729012885 dimer interface [polypeptide binding]; other site 869729012886 conserved gate region; other site 869729012887 putative PBP binding loops; other site 869729012888 ABC-ATPase subunit interface; other site 869729012889 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 869729012890 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869729012891 substrate binding pocket [chemical binding]; other site 869729012892 membrane-bound complex binding site; other site 869729012893 hinge residues; other site 869729012894 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 869729012895 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 869729012896 Walker A/P-loop; other site 869729012897 ATP binding site [chemical binding]; other site 869729012898 Q-loop/lid; other site 869729012899 ABC transporter signature motif; other site 869729012900 Walker B; other site 869729012901 D-loop; other site 869729012902 H-loop/switch region; other site 869729012903 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 869729012904 dimer interface [polypeptide binding]; other site 869729012905 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 869729012906 hypothetical protein; Provisional; Region: PRK10220 869729012907 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 869729012908 PhnA protein; Region: PhnA; pfam03831 869729012909 hypothetical protein; Provisional; Region: PRK09866 869729012910 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 869729012911 G1 box; other site 869729012912 GTP/Mg2+ binding site [chemical binding]; other site 869729012913 G2 box; other site 869729012914 Switch I region; other site 869729012915 G3 box; other site 869729012916 Switch II region; other site 869729012917 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 869729012918 G2 box; other site 869729012919 Switch I region; other site 869729012920 G3 box; other site 869729012921 Switch II region; other site 869729012922 G4 box; other site 869729012923 G5 box; other site 869729012924 YjcZ-like protein; Region: YjcZ; pfam13990 869729012925 proline/glycine betaine transporter; Provisional; Region: PRK10642 869729012926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729012927 putative substrate translocation pore; other site 869729012928 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 869729012929 sensor protein BasS/PmrB; Provisional; Region: PRK10755 869729012930 HAMP domain; Region: HAMP; pfam00672 869729012931 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869729012932 dimer interface [polypeptide binding]; other site 869729012933 phosphorylation site [posttranslational modification] 869729012934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729012935 ATP binding site [chemical binding]; other site 869729012936 Mg2+ binding site [ion binding]; other site 869729012937 G-X-G motif; other site 869729012938 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 869729012939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729012940 active site 869729012941 phosphorylation site [posttranslational modification] 869729012942 intermolecular recognition site; other site 869729012943 dimerization interface [polypeptide binding]; other site 869729012944 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869729012945 DNA binding site [nucleotide binding] 869729012946 putative metal dependent hydrolase; Provisional; Region: PRK11598 869729012947 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 869729012948 Sulfatase; Region: Sulfatase; pfam00884 869729012949 arginine:agmatin antiporter; Provisional; Region: PRK10644 869729012950 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 869729012951 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729012952 arginine decarboxylase; Provisional; Region: PRK15029 869729012953 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 869729012954 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 869729012955 homodimer interface [polypeptide binding]; other site 869729012956 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729012957 catalytic residue [active] 869729012958 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 869729012959 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 869729012960 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729012961 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729012962 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 869729012963 alpha-galactosidase; Provisional; Region: PRK15076 869729012964 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 869729012965 NAD binding site [chemical binding]; other site 869729012966 sugar binding site [chemical binding]; other site 869729012967 divalent metal binding site [ion binding]; other site 869729012968 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 869729012969 dimer interface [polypeptide binding]; other site 869729012970 hypothetical protein; Provisional; Region: PRK09867 869729012971 fumarate hydratase; Provisional; Region: PRK15389 869729012972 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 869729012973 Fumarase C-terminus; Region: Fumerase_C; pfam05683 869729012974 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 869729012975 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 869729012976 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 869729012977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729012978 active site 869729012979 phosphorylation site [posttranslational modification] 869729012980 intermolecular recognition site; other site 869729012981 dimerization interface [polypeptide binding]; other site 869729012982 Transcriptional regulator; Region: CitT; pfam12431 869729012983 sensory histidine kinase DcuS; Provisional; Region: PRK11086 869729012984 PAS domain; Region: PAS; smart00091 869729012985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729012986 ATP binding site [chemical binding]; other site 869729012987 Mg2+ binding site [ion binding]; other site 869729012988 G-X-G motif; other site 869729012989 Uncharacterized conserved protein [Function unknown]; Region: COG3592 869729012990 Predicted acetyltransferase [General function prediction only]; Region: COG2388 869729012991 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 869729012992 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 869729012993 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 869729012994 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 869729012995 dimer interface [polypeptide binding]; other site 869729012996 putative anticodon binding site; other site 869729012997 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 869729012998 motif 1; other site 869729012999 active site 869729013000 motif 2; other site 869729013001 motif 3; other site 869729013002 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 869729013003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729013004 putative substrate translocation pore; other site 869729013005 POT family; Region: PTR2; pfam00854 869729013006 lysine decarboxylase CadA; Provisional; Region: PRK15400 869729013007 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 869729013008 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 869729013009 homodimer interface [polypeptide binding]; other site 869729013010 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729013011 catalytic residue [active] 869729013012 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 869729013013 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 869729013014 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 869729013015 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869729013016 DNA binding site [nucleotide binding] 869729013017 putative transcriptional regulator; Provisional; Region: PRK11640 869729013018 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869729013019 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 869729013020 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 869729013021 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 869729013022 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 869729013023 DsbD alpha interface [polypeptide binding]; other site 869729013024 catalytic residues [active] 869729013025 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 869729013026 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 869729013027 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 869729013028 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 869729013029 Aspartase; Region: Aspartase; cd01357 869729013030 active sites [active] 869729013031 tetramer interface [polypeptide binding]; other site 869729013032 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 869729013033 putative transporter; Provisional; Region: PRK11021 869729013034 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 869729013035 oligomerisation interface [polypeptide binding]; other site 869729013036 mobile loop; other site 869729013037 roof hairpin; other site 869729013038 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 869729013039 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 869729013040 ring oligomerisation interface [polypeptide binding]; other site 869729013041 ATP/Mg binding site [chemical binding]; other site 869729013042 stacking interactions; other site 869729013043 hinge regions; other site 869729013044 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 869729013045 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 869729013046 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869729013047 FeS/SAM binding site; other site 869729013048 elongation factor P; Validated; Region: PRK00529 869729013049 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 869729013050 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 869729013051 RNA binding site [nucleotide binding]; other site 869729013052 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 869729013053 RNA binding site [nucleotide binding]; other site 869729013054 entericidin A; Provisional; Region: PRK09810 869729013055 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 869729013056 multidrug efflux system protein; Provisional; Region: PRK11431 869729013057 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 869729013058 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 869729013059 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 869729013060 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 869729013061 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 869729013062 Iron-sulfur protein interface; other site 869729013063 proximal quinone binding site [chemical binding]; other site 869729013064 C-subunit interface; other site 869729013065 distal quinone binding site; other site 869729013066 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 869729013067 D-subunit interface [polypeptide binding]; other site 869729013068 Iron-sulfur protein interface; other site 869729013069 proximal quinone binding site [chemical binding]; other site 869729013070 distal quinone binding site [chemical binding]; other site 869729013071 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 869729013072 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 869729013073 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 869729013074 L-aspartate oxidase; Provisional; Region: PRK06175 869729013075 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 869729013076 poxB regulator PoxA; Provisional; Region: PRK09350 869729013077 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 869729013078 motif 1; other site 869729013079 dimer interface [polypeptide binding]; other site 869729013080 active site 869729013081 motif 2; other site 869729013082 motif 3; other site 869729013083 inner membrane transporter YjeM; Provisional; Region: PRK15238 869729013084 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 869729013085 putative mechanosensitive channel protein; Provisional; Region: PRK10929 869729013086 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 869729013087 DNA-binding site [nucleotide binding]; DNA binding site 869729013088 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 869729013089 Mechanosensitive ion channel; Region: MS_channel; pfam00924 869729013090 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 869729013091 GTPase RsgA; Reviewed; Region: PRK12288 869729013092 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 869729013093 RNA binding site [nucleotide binding]; other site 869729013094 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 869729013095 GTPase/Zn-binding domain interface [polypeptide binding]; other site 869729013096 GTP/Mg2+ binding site [chemical binding]; other site 869729013097 G4 box; other site 869729013098 G5 box; other site 869729013099 G1 box; other site 869729013100 Switch I region; other site 869729013101 G2 box; other site 869729013102 G3 box; other site 869729013103 Switch II region; other site 869729013104 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 869729013105 catalytic site [active] 869729013106 putative active site [active] 869729013107 putative substrate binding site [chemical binding]; other site 869729013108 dimer interface [polypeptide binding]; other site 869729013109 epoxyqueuosine reductase; Region: TIGR00276 869729013110 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 869729013111 putative carbohydrate kinase; Provisional; Region: PRK10565 869729013112 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 869729013113 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 869729013114 putative substrate binding site [chemical binding]; other site 869729013115 putative ATP binding site [chemical binding]; other site 869729013116 ADP-binding protein; Provisional; Region: PRK10646 869729013117 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 869729013118 AMIN domain; Region: AMIN; pfam11741 869729013119 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 869729013120 active site 869729013121 metal binding site [ion binding]; metal-binding site 869729013122 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 869729013123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729013124 ATP binding site [chemical binding]; other site 869729013125 Mg2+ binding site [ion binding]; other site 869729013126 G-X-G motif; other site 869729013127 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 869729013128 ATP binding site [chemical binding]; other site 869729013129 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 869729013130 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 869729013131 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 869729013132 bacterial Hfq-like; Region: Hfq; cd01716 869729013133 hexamer interface [polypeptide binding]; other site 869729013134 Sm1 motif; other site 869729013135 RNA binding site [nucleotide binding]; other site 869729013136 Sm2 motif; other site 869729013137 GTPase HflX; Provisional; Region: PRK11058 869729013138 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 869729013139 HflX GTPase family; Region: HflX; cd01878 869729013140 G1 box; other site 869729013141 GTP/Mg2+ binding site [chemical binding]; other site 869729013142 Switch I region; other site 869729013143 G2 box; other site 869729013144 G3 box; other site 869729013145 Switch II region; other site 869729013146 G4 box; other site 869729013147 G5 box; other site 869729013148 FtsH protease regulator HflK; Provisional; Region: PRK10930 869729013149 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 869729013150 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 869729013151 FtsH protease regulator HflC; Provisional; Region: PRK11029 869729013152 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 869729013153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 869729013154 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 869729013155 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 869729013156 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 869729013157 IMP binding site; other site 869729013158 Predicted transcriptional regulator [Transcription]; Region: COG1959 869729013159 transcriptional repressor NsrR; Provisional; Region: PRK11014 869729013160 exoribonuclease R; Provisional; Region: PRK11642 869729013161 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 869729013162 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 869729013163 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 869729013164 RNB domain; Region: RNB; pfam00773 869729013165 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 869729013166 RNA binding site [nucleotide binding]; other site 869729013167 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 869729013168 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 869729013169 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 869729013170 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 869729013171 PspA/IM30 family; Region: PspA_IM30; pfam04012 869729013172 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 869729013173 Predicted membrane protein [Function unknown]; Region: COG3766 869729013174 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 869729013175 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 869729013176 Predicted integral membrane protein [Function unknown]; Region: COG5463 869729013177 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 869729013178 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 869729013179 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 869729013180 FAD binding site [chemical binding]; other site 869729013181 substrate binding site [chemical binding]; other site 869729013182 catalytic residues [active] 869729013183 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 869729013184 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 869729013185 esterase; Provisional; Region: PRK10566 869729013186 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 869729013187 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 869729013188 transcriptional repressor UlaR; Provisional; Region: PRK13509 869729013189 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 869729013190 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869729013191 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 869729013192 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 869729013193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 869729013194 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 869729013195 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 869729013196 active site 869729013197 P-loop; other site 869729013198 phosphorylation site [posttranslational modification] 869729013199 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869729013200 active site 869729013201 phosphorylation site [posttranslational modification] 869729013202 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 869729013203 active site 869729013204 dimer interface [polypeptide binding]; other site 869729013205 magnesium binding site [ion binding]; other site 869729013206 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 869729013207 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 869729013208 AP (apurinic/apyrimidinic) site pocket; other site 869729013209 DNA interaction; other site 869729013210 Metal-binding active site; metal-binding site 869729013211 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 869729013212 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 869729013213 intersubunit interface [polypeptide binding]; other site 869729013214 active site 869729013215 Zn2+ binding site [ion binding]; other site 869729013216 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 869729013217 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 869729013218 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 869729013219 dimer interface [polypeptide binding]; other site 869729013220 ssDNA binding site [nucleotide binding]; other site 869729013221 tetramer (dimer of dimers) interface [polypeptide binding]; other site 869729013222 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 869729013223 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 869729013224 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 869729013225 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 869729013226 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 869729013227 HipA-like N-terminal domain; Region: HipA_N; pfam07805 869729013228 HipA-like C-terminal domain; Region: HipA_C; pfam07804 869729013229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729013230 putative substrate translocation pore; other site 869729013231 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 869729013232 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 869729013233 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 869729013234 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 869729013235 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 869729013236 L-aspartate oxidase; Provisional; Region: PRK06175 869729013237 L-aspartate oxidase; Provisional; Region: PRK06175 869729013238 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 869729013239 Coenzyme A transferase; Region: CoA_trans; smart00882 869729013240 Coenzyme A transferase; Region: CoA_trans; cl17247 869729013241 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 869729013242 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 869729013243 substrate binding site [chemical binding]; other site 869729013244 oxyanion hole (OAH) forming residues; other site 869729013245 trimer interface [polypeptide binding]; other site 869729013246 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 869729013247 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 869729013248 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337 869729013249 putative NAD(P) binding site [chemical binding]; other site 869729013250 active site 869729013251 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869729013252 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869729013253 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 869729013254 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 869729013255 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 869729013256 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 869729013257 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 869729013258 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 869729013259 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 869729013260 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 869729013261 Hemerythrin-like domain; Region: Hr-like; cd12108 869729013262 Fe binding site [ion binding]; other site 869729013263 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 869729013264 EamA-like transporter family; Region: EamA; pfam00892 869729013265 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 869729013266 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 869729013267 NADP binding site [chemical binding]; other site 869729013268 Predicted transcriptional regulators [Transcription]; Region: COG1733 869729013269 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 869729013270 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 869729013271 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 869729013272 active site 869729013273 metal binding site [ion binding]; metal-binding site 869729013274 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 869729013275 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 869729013276 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 869729013277 active site 869729013278 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 869729013279 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 869729013280 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 869729013281 Domain of unknown function DUF21; Region: DUF21; pfam01595 869729013282 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 869729013283 Transporter associated domain; Region: CorC_HlyC; smart01091 869729013284 methionine sulfoxide reductase A; Provisional; Region: PRK00058 869729013285 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 869729013286 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 869729013287 Surface antigen; Region: Bac_surface_Ag; pfam01103 869729013288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 869729013289 Family of unknown function (DUF490); Region: DUF490; pfam04357 869729013290 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 869729013291 putative active site pocket [active] 869729013292 dimerization interface [polypeptide binding]; other site 869729013293 putative catalytic residue [active] 869729013294 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 869729013295 dimer interface [polypeptide binding]; other site 869729013296 substrate binding site [chemical binding]; other site 869729013297 metal binding sites [ion binding]; metal-binding site 869729013298 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 869729013299 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 869729013300 putative ligand binding site [chemical binding]; other site 869729013301 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 869729013302 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 869729013303 Walker A/P-loop; other site 869729013304 ATP binding site [chemical binding]; other site 869729013305 Q-loop/lid; other site 869729013306 ABC transporter signature motif; other site 869729013307 Walker B; other site 869729013308 D-loop; other site 869729013309 H-loop/switch region; other site 869729013310 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 869729013311 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869729013312 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 869729013313 TM-ABC transporter signature motif; other site 869729013314 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869729013315 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 869729013316 TM-ABC transporter signature motif; other site 869729013317 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 869729013318 AMP binding site [chemical binding]; other site 869729013319 metal binding site [ion binding]; metal-binding site 869729013320 active site 869729013321 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 869729013322 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 869729013323 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869729013324 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869729013325 hypothetical protein; Provisional; Region: PRK05255 869729013326 peptidase PmbA; Provisional; Region: PRK11040 869729013327 Cytochrome b562; Region: Cytochrom_B562; cl01546 869729013328 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 869729013329 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869729013330 FeS/SAM binding site; other site 869729013331 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 869729013332 ATP cone domain; Region: ATP-cone; pfam03477 869729013333 Class III ribonucleotide reductase; Region: RNR_III; cd01675 869729013334 effector binding site; other site 869729013335 active site 869729013336 Zn binding site [ion binding]; other site 869729013337 glycine loop; other site 869729013338 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 869729013339 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 869729013340 Ca binding site [ion binding]; other site 869729013341 active site 869729013342 catalytic site [active] 869729013343 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 869729013344 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 869729013345 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869729013346 active site turn [active] 869729013347 phosphorylation site [posttranslational modification] 869729013348 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869729013349 trehalose repressor; Provisional; Region: treR; PRK09492 869729013350 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869729013351 DNA binding site [nucleotide binding] 869729013352 domain linker motif; other site 869729013353 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 869729013354 dimerization interface [polypeptide binding]; other site 869729013355 ligand binding site [chemical binding]; other site 869729013356 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 869729013357 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 869729013358 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 869729013359 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 869729013360 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869729013361 motif II; other site 869729013362 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 869729013363 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 869729013364 homotrimer interaction site [polypeptide binding]; other site 869729013365 putative active site [active] 869729013366 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 869729013367 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 869729013368 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 869729013369 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 869729013370 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 869729013371 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 869729013372 PyrBI operon leader peptide; Region: PyrBI_leader; pfam08052 869729013373 Arginine repressor [Transcription]; Region: ArgR; COG1438 869729013374 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 869729013375 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 869729013376 Predicted membrane protein [Function unknown]; Region: COG1288 869729013377 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 869729013378 ornithine carbamoyltransferase; Validated; Region: PRK02102 869729013379 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 869729013380 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 869729013381 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 869729013382 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 869729013383 putative substrate binding site [chemical binding]; other site 869729013384 nucleotide binding site [chemical binding]; other site 869729013385 nucleotide binding site [chemical binding]; other site 869729013386 homodimer interface [polypeptide binding]; other site 869729013387 arginine deiminase; Provisional; Region: PRK01388 869729013388 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 869729013389 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 869729013390 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 869729013391 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 869729013392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 869729013393 RNase E inhibitor protein; Provisional; Region: PRK11191 869729013394 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 869729013395 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869729013396 Coenzyme A binding pocket [chemical binding]; other site 869729013397 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 869729013398 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 869729013399 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 869729013400 HIGH motif; other site 869729013401 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 869729013402 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 869729013403 active site 869729013404 KMSKS motif; other site 869729013405 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 869729013406 tRNA binding surface [nucleotide binding]; other site 869729013407 anticodon binding site; other site 869729013408 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 869729013409 DNA polymerase III subunit chi; Validated; Region: PRK05728 869729013410 multifunctional aminopeptidase A; Provisional; Region: PRK00913 869729013411 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 869729013412 interface (dimer of trimers) [polypeptide binding]; other site 869729013413 Substrate-binding/catalytic site; other site 869729013414 Zn-binding sites [ion binding]; other site 869729013415 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 869729013416 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 869729013417 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 869729013418 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 869729013419 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 869729013420 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 869729013421 Walker A motif; other site 869729013422 ATP binding site [chemical binding]; other site 869729013423 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 869729013424 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869729013425 DNA binding site [nucleotide binding] 869729013426 domain linker motif; other site 869729013427 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 869729013428 putative dimerization interface [polypeptide binding]; other site 869729013429 putative ligand binding site [chemical binding]; other site 869729013430 fructuronate transporter; Provisional; Region: PRK10034; cl15264 869729013431 gluconate transporter; Region: gntP; TIGR00791 869729013432 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 869729013433 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 869729013434 NADP binding site [chemical binding]; other site 869729013435 homodimer interface [polypeptide binding]; other site 869729013436 active site 869729013437 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 869729013438 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 869729013439 putative NAD(P) binding site [chemical binding]; other site 869729013440 catalytic Zn binding site [ion binding]; other site 869729013441 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 869729013442 ATP-binding site [chemical binding]; other site 869729013443 Gluconate-6-phosphate binding site [chemical binding]; other site 869729013444 Shikimate kinase; Region: SKI; pfam01202 869729013445 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 869729013446 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 869729013447 putative NAD(P) binding site [chemical binding]; other site 869729013448 putative substrate binding site [chemical binding]; other site 869729013449 catalytic Zn binding site [ion binding]; other site 869729013450 structural Zn binding site [ion binding]; other site 869729013451 dimer interface [polypeptide binding]; other site 869729013452 integrase; Provisional; Region: PRK09692 869729013453 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 869729013454 active site 869729013455 Int/Topo IB signature motif; other site 869729013456 Part of AAA domain; Region: AAA_19; pfam13245 869729013457 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 869729013458 AAA domain; Region: AAA_12; pfam13087 869729013459 C-terminal domain of Escherichia coli uncharacterized protein yjhR and similar proteins; Region: PLDc_yjhR_C_like; cd09118 869729013460 putative active site [active] 869729013461 catalytic site [active] 869729013462 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 869729013463 Sulfatase; Region: Sulfatase; cl17466 869729013464 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 869729013465 MarR family; Region: MarR_2; cl17246 869729013466 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 869729013467 PapG carbohydrate / receptor binding domain (CBD); PapG, the adhesin of the P-pili, is situated at the tip, mediating the attachment of uropathogenic Escherichia coli to the uroepithelium of the human kidney; PapG has a two-domain architecture: a...; Region: PapG_CBD; cd00239 869729013468 putative membrane interaction site; other site 869729013469 receptor/carbohydrate binding site; other site 869729013470 PapG chaperone-binding domain; Region: PapG_C; pfam03628 869729013471 Fimbrial protein; Region: Fimbrial; pfam00419 869729013472 Fimbrial protein; Region: Fimbrial; pfam00419 869729013473 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 869729013474 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 869729013475 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 869729013476 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 869729013477 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 869729013478 PapC N-terminal domain; Region: PapC_N; pfam13954 869729013479 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 869729013480 PapC C-terminal domain; Region: PapC_C; pfam13953 869729013481 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 869729013482 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 869729013483 Adhesin biosynthesis transcription regulatory protein; Region: PapB; pfam03333 869729013484 FaeA-like protein; Region: FaeA; pfam04703 869729013485 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 869729013486 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 869729013487 PapC N-terminal domain; Region: PapC_N; pfam13954 869729013488 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 869729013489 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 869729013490 PapC C-terminal domain; Region: PapC_C; pfam13953 869729013491 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 869729013492 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 869729013493 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 869729013494 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 869729013495 Predicted membrane protein [Function unknown]; Region: COG2259 869729013496 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 869729013497 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 869729013498 phosphate binding site [ion binding]; other site 869729013499 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869729013500 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869729013501 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 869729013502 catalytic residues [active] 869729013503 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 869729013504 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 869729013505 Transposase; Region: DEDD_Tnp_IS110; pfam01548 869729013506 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 869729013507 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 869729013508 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 869729013509 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 869729013510 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 869729013511 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 869729013512 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 869729013513 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 869729013514 Transposase; Region: HTH_Tnp_1; pfam01527 869729013515 Integrase core domain; Region: rve; pfam00665 869729013516 Winged helix-turn helix; Region: HTH_29; pfam13551 869729013517 Homeodomain-like domain; Region: HTH_23; cl17451 869729013518 Rho-activating domain of cytotoxic necrotizing factor; Region: CNF1; pfam05785 869729013519 Urea transporter; Region: UT; cl01829 869729013520 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 869729013521 HlyD family secretion protein; Region: HlyD_3; pfam13437 869729013522 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 869729013523 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 869729013524 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869729013525 ATP-binding cassette domain of hemolysin B, subfamily C; Region: ABCC_Hemolysin; cd03252 869729013526 Walker A/P-loop; other site 869729013527 ATP binding site [chemical binding]; other site 869729013528 Q-loop/lid; other site 869729013529 ABC transporter signature motif; other site 869729013530 Walker B; other site 869729013531 D-loop; other site 869729013532 H-loop/switch region; other site 869729013533 RTX N-terminal domain; Region: RTX; pfam02382 869729013534 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 869729013535 RTX C-terminal domain; Region: RTX_C; pfam08339 869729013536 RTX toxin acyltransferase family; Region: HlyC; pfam02794 869729013537 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 869729013538 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 869729013539 Moco binding site; other site 869729013540 metal coordination site [ion binding]; other site 869729013541 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 869729013542 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869729013543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729013544 active site 869729013545 phosphorylation site [posttranslational modification] 869729013546 intermolecular recognition site; other site 869729013547 dimerization interface [polypeptide binding]; other site 869729013548 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869729013549 DNA binding site [nucleotide binding] 869729013550 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869729013551 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869729013552 dimer interface [polypeptide binding]; other site 869729013553 phosphorylation site [posttranslational modification] 869729013554 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729013555 ATP binding site [chemical binding]; other site 869729013556 Mg2+ binding site [ion binding]; other site 869729013557 G-X-G motif; other site 869729013558 Integrase core domain; Region: rve; pfam00665 869729013559 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025 869729013560 Transposase; Region: HTH_Tnp_1; pfam01527 869729013561 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 869729013562 potential frameshift: common BLAST hit: gi|215481845|ref|YP_002324027.1| Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase family 869729013563 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 869729013564 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 869729013565 cofactor binding site; other site 869729013566 DNA binding site [nucleotide binding] 869729013567 substrate interaction site [chemical binding]; other site 869729013568 potential frameshift: common BLAST hit: gi|283786955|ref|YP_003366820.1| putative conjugative transfer system protein TraG (fragment) 869729013569 ImpA domain protein; Region: DUF3702; pfam12486 869729013570 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 869729013571 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 869729013572 haemagglutination activity domain; Region: Haemagg_act; pfam05860 869729013573 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 869729013574 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 869729013575 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 869729013576 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 869729013577 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 869729013578 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 869729013579 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 869729013580 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 869729013581 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 869729013582 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 869729013583 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 869729013584 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 869729013585 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 869729013586 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869729013587 catalytic residue [active] 869729013588 permease DsdX; Provisional; Region: PRK09921 869729013589 gluconate transporter; Region: gntP; TIGR00791 869729013590 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 869729013591 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729013592 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 869729013593 dimerization interface [polypeptide binding]; other site 869729013594 substrate binding pocket [chemical binding]; other site 869729013595 Integrase core domain; Region: rve; pfam00665 869729013596 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 869729013597 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 869729013598 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 869729013599 Propanediol utilisation protein PduL; Region: PduL; pfam06130 869729013600 Propanediol utilisation protein PduL; Region: PduL; pfam06130 869729013601 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 869729013602 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 869729013603 Hexamer interface [polypeptide binding]; other site 869729013604 Hexagonal pore residue; other site 869729013605 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 869729013606 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 869729013607 Pyruvate formate lyase; Region: PFL; pfam02901 869729013608 Pyruvate formate lyase; Region: PFL; pfam02901 869729013609 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 869729013610 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 869729013611 dimer interface [polypeptide binding]; other site 869729013612 active site 869729013613 glycine loop; other site 869729013614 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 869729013615 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 869729013616 putative active site [active] 869729013617 metal binding site [ion binding]; metal-binding site 869729013618 Ethanolamine utilisation protein EutN/carboxysome; Region: EutN_CcmL; pfam03319 869729013619 Hexamer/Pentamer interface [polypeptide binding]; other site 869729013620 central pore; other site 869729013621 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 869729013622 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 869729013623 putative catalytic cysteine [active] 869729013624 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 869729013625 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 869729013626 Hexamer interface [polypeptide binding]; other site 869729013627 Hexagonal pore residue; other site 869729013628 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 869729013629 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 869729013630 Hexamer interface [polypeptide binding]; other site 869729013631 Hexagonal pore residue; other site 869729013632 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 869729013633 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 869729013634 Hexamer interface [polypeptide binding]; other site 869729013635 Hexagonal pore residue; other site 869729013636 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 869729013637 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869729013638 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869729013639 putative transposase OrfB; Reviewed; Region: PHA02517 869729013640 HTH-like domain; Region: HTH_21; pfam13276 869729013641 Integrase core domain; Region: rve; pfam00665 869729013642 Integrase core domain; Region: rve_3; cl15866 869729013643 Transposase; Region: HTH_Tnp_1; cl17663 869729013644 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 869729013645 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 869729013646 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869729013647 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729013648 homodimer interface [polypeptide binding]; other site 869729013649 catalytic residue [active] 869729013650 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 869729013651 Transposase; Region: HTH_Tnp_1; cl17663 869729013652 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 869729013653 Transposase; Region: HTH_Tnp_1; cl17663 869729013654 Integrase core domain; Region: rve; pfam00665 869729013655 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 869729013656 Restriction endonuclease; Region: Mrr_cat; pfam04471 869729013657 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 869729013658 Predicted GTPase [General function prediction only]; Region: COG3596 869729013659 YfjP GTPase; Region: YfjP; cd11383 869729013660 G1 box; other site 869729013661 GTP/Mg2+ binding site [chemical binding]; other site 869729013662 Switch I region; other site 869729013663 G2 box; other site 869729013664 Switch II region; other site 869729013665 G3 box; other site 869729013666 G4 box; other site 869729013667 G5 box; other site 869729013668 HTH domain; Region: HTH_11; cl17392 869729013669 WYL domain; Region: WYL; pfam13280 869729013670 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 869729013671 Domain of unknown function (DUF932); Region: DUF932; pfam06067 869729013672 Antirestriction protein; Region: Antirestrict; pfam03230 869729013673 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 869729013674 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 869729013675 MPN+ (JAMM) motif; other site 869729013676 Zinc-binding site [ion binding]; other site 869729013677 Protein of unknown function (DUF987); Region: DUF987; pfam06174 869729013678 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 869729013679 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 869729013680 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 869729013681 Predicted ATP-dependent Lon-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG4930 869729013682 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 869729013683 HNH endonuclease; Region: HNH_2; pfam13391 869729013684 Domain of unknown function (DUF303); Region: DUF303; pfam03629 869729013685 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 869729013686 Kelch motif; Region: Kelch_1; pfam01344 869729013687 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 869729013688 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 869729013689 Int/Topo IB signature motif; other site 869729013690 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 869729013691 Int/Topo IB signature motif; other site 869729013692 Fimbrial protein; Region: Fimbrial; cl01416 869729013693 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 869729013694 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 869729013695 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 869729013696 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 869729013697 outer membrane usher protein; Provisional; Region: PRK15193 869729013698 PapC N-terminal domain; Region: PapC_N; pfam13954 869729013699 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 869729013700 PapC C-terminal domain; Region: PapC_C; pfam13953 869729013701 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 869729013702 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 869729013703 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 869729013704 mannosyl binding site [chemical binding]; other site 869729013705 Fimbrial protein; Region: Fimbrial; pfam00419 869729013706 mannonate dehydratase; Region: uxuA; TIGR00695 869729013707 mannonate dehydratase; Provisional; Region: PRK03906 869729013708 D-mannonate oxidoreductase; Provisional; Region: PRK15037 869729013709 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 869729013710 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 869729013711 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 869729013712 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869729013713 DNA-binding site [nucleotide binding]; DNA binding site 869729013714 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 869729013715 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 869729013716 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 869729013717 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 869729013718 active site 869729013719 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 869729013720 dimerization domain swap beta strand [polypeptide binding]; other site 869729013721 regulatory protein interface [polypeptide binding]; other site 869729013722 active site 869729013723 regulatory phosphorylation site [posttranslational modification]; other site 869729013724 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 869729013725 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 869729013726 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 869729013727 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 869729013728 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 869729013729 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 869729013730 Dak1 domain; Region: Dak1; pfam02733 869729013731 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 869729013732 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 869729013733 dimer interface [polypeptide binding]; other site 869729013734 active site 869729013735 metal binding site [ion binding]; metal-binding site 869729013736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729013737 Major Facilitator Superfamily; Region: MFS_1; pfam07690 869729013738 putative substrate translocation pore; other site 869729013739 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 869729013740 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869729013741 BCCT family transporter; Region: BCCT; pfam02028 869729013742 glycerate kinase; Region: TIGR00045 869729013743 tartronate semialdehyde reductase; Provisional; Region: PRK15059 869729013744 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 869729013745 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 869729013746 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 869729013747 glyoxylate carboligase; Provisional; Region: PRK11269 869729013748 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 869729013749 PYR/PP interface [polypeptide binding]; other site 869729013750 dimer interface [polypeptide binding]; other site 869729013751 TPP binding site [chemical binding]; other site 869729013752 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 869729013753 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 869729013754 TPP-binding site [chemical binding]; other site 869729013755 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 869729013756 GAF domain; Region: GAF; pfam01590 869729013757 PAS domain; Region: PAS; smart00091 869729013758 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729013759 Walker A motif; other site 869729013760 ATP binding site [chemical binding]; other site 869729013761 Walker B motif; other site 869729013762 arginine finger; other site 869729013763 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 869729013764 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 869729013765 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 869729013766 cell density-dependent motility repressor; Provisional; Region: PRK10082 869729013767 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 869729013768 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 869729013769 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 869729013770 dimer interface [polypeptide binding]; other site 869729013771 active site 869729013772 hypothetical protein; Provisional; Region: PRK10519 869729013773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 869729013774 Nucleoside recognition; Region: Gate; pfam07670 869729013775 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 869729013776 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 869729013777 potential frameshift: common BLAST hit: gi|117626652|ref|YP_859975.1| permease 869729013778 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 869729013779 SdiA-regulated; Region: SdiA-regulated; pfam06977 869729013780 SdiA-regulated; Region: SdiA-regulated; cd09971 869729013781 putative active site [active] 869729013782 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 869729013783 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 869729013784 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 869729013785 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 869729013786 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 869729013787 Predicted membrane protein [Function unknown]; Region: COG2733 869729013788 putative transposase; Provisional; Region: PRK09857 869729013789 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 869729013790 Uncharacterized conserved protein [Function unknown]; Region: COG1479 869729013791 Protein of unknown function DUF262; Region: DUF262; pfam03235 869729013792 Protein of unknown function DUF262; Region: DUF262; pfam03235 869729013793 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 869729013794 Uncharacterized conserved protein [Function unknown]; Region: COG3586 869729013795 endoribonuclease SymE; Provisional; Region: PRK13605 869729013796 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 869729013797 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 869729013798 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 869729013799 HsdM N-terminal domain; Region: HsdM_N; pfam12161 869729013800 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 869729013801 Methyltransferase domain; Region: Methyltransf_26; pfam13659 869729013802 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 869729013803 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 869729013804 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 869729013805 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869729013806 ATP binding site [chemical binding]; other site 869729013807 putative Mg++ binding site [ion binding]; other site 869729013808 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 869729013809 Mrr N-terminal domain; Region: Mrr_N; pfam14338 869729013810 Restriction endonuclease; Region: Mrr_cat; pfam04471 869729013811 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 869729013812 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 869729013813 P-loop, Walker A motif; other site 869729013814 Base recognition motif; other site 869729013815 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 869729013816 Uncharacterized small protein [Function unknown]; Region: COG2879 869729013817 carbon starvation protein A; Provisional; Region: PRK15015 869729013818 Carbon starvation protein CstA; Region: CstA; pfam02554 869729013819 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 869729013820 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 869729013821 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 869729013822 dimer interface [polypeptide binding]; other site 869729013823 ligand binding site [chemical binding]; other site 869729013824 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869729013825 dimerization interface [polypeptide binding]; other site 869729013826 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 869729013827 dimer interface [polypeptide binding]; other site 869729013828 putative CheW interface [polypeptide binding]; other site 869729013829 DctM-like transporters; Region: DctM; pfam06808 869729013830 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 869729013831 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 869729013832 potential frameshift: common BLAST hit: gi|260858531|ref|YP_003232422.1| putative C4-dicarboxylate-binding periplasmic protein 869729013833 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 869729013834 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 869729013835 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869729013836 DNA-binding site [nucleotide binding]; DNA binding site 869729013837 Transcriptional regulators [Transcription]; Region: GntR; COG1802 869729013838 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 869729013839 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 869729013840 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 869729013841 putative NAD(P) binding site [chemical binding]; other site 869729013842 catalytic Zn binding site [ion binding]; other site 869729013843 structural Zn binding site [ion binding]; other site 869729013844 phosphoglycerol transferase I; Provisional; Region: PRK03776 869729013845 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 869729013846 hypothetical protein; Provisional; Region: PRK11667 869729013847 DNA replication protein DnaC; Validated; Region: PRK07952 869729013848 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869729013849 Walker A motif; other site 869729013850 ATP binding site [chemical binding]; other site 869729013851 Walker B motif; other site 869729013852 primosomal protein DnaI; Provisional; Region: PRK02854 869729013853 hypothetical protein; Provisional; Region: PRK09917 869729013854 Uncharacterized conserved protein [Function unknown]; Region: COG2966 869729013855 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 869729013856 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 869729013857 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869729013858 DNA binding residues [nucleotide binding] 869729013859 dimerization interface [polypeptide binding]; other site 869729013860 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 869729013861 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869729013862 DNA binding residues [nucleotide binding] 869729013863 dimerization interface [polypeptide binding]; other site 869729013864 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 869729013865 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 869729013866 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 869729013867 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 869729013868 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 869729013869 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 869729013870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729013871 S-adenosylmethionine binding site [chemical binding]; other site 869729013872 DNA polymerase III subunit psi; Validated; Region: PRK06856 869729013873 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 869729013874 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869729013875 Coenzyme A binding pocket [chemical binding]; other site 869729013876 dUMP phosphatase; Provisional; Region: PRK09449 869729013877 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869729013878 motif II; other site 869729013879 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 869729013880 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 869729013881 G1 box; other site 869729013882 putative GEF interaction site [polypeptide binding]; other site 869729013883 GTP/Mg2+ binding site [chemical binding]; other site 869729013884 Switch I region; other site 869729013885 G2 box; other site 869729013886 G3 box; other site 869729013887 Switch II region; other site 869729013888 G4 box; other site 869729013889 G5 box; other site 869729013890 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 869729013891 periplasmic protein; Provisional; Region: PRK10568 869729013892 BON domain; Region: BON; pfam04972 869729013893 BON domain; Region: BON; pfam04972 869729013894 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 869729013895 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 869729013896 active site 869729013897 nucleophile elbow; other site 869729013898 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 869729013899 active site 869729013900 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 869729013901 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869729013902 FeS/SAM binding site; other site 869729013903 hypothetical protein; Provisional; Region: PRK10977 869729013904 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 869729013905 intersubunit interface [polypeptide binding]; other site 869729013906 active site 869729013907 catalytic residue [active] 869729013908 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 869729013909 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 869729013910 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 869729013911 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 869729013912 phosphopentomutase; Provisional; Region: PRK05362 869729013913 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 869729013914 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 869729013915 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 869729013916 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 869729013917 HipA-like N-terminal domain; Region: HipA_N; pfam07805 869729013918 HipA-like C-terminal domain; Region: HipA_C; pfam07804 869729013919 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 869729013920 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 869729013921 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 869729013922 hypothetical protein; Provisional; Region: PRK11246 869729013923 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 869729013924 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869729013925 motif II; other site 869729013926 DNA repair protein RadA; Region: sms; TIGR00416 869729013927 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 869729013928 Walker A motif/ATP binding site; other site 869729013929 ATP binding site [chemical binding]; other site 869729013930 Walker B motif; other site 869729013931 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 869729013932 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869729013933 non-specific DNA binding site [nucleotide binding]; other site 869729013934 salt bridge; other site 869729013935 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 869729013936 sequence-specific DNA binding site [nucleotide binding]; other site 869729013937 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 869729013938 active site 869729013939 (T/H)XGH motif; other site 869729013940 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 869729013941 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 869729013942 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869729013943 non-specific DNA binding site [nucleotide binding]; other site 869729013944 salt bridge; other site 869729013945 sequence-specific DNA binding site [nucleotide binding]; other site 869729013946 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 869729013947 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869729013948 Walker A/P-loop; other site 869729013949 ATP binding site [chemical binding]; other site 869729013950 Q-loop/lid; other site 869729013951 ABC transporter signature motif; other site 869729013952 Walker B; other site 869729013953 D-loop; other site 869729013954 H-loop/switch region; other site 869729013955 ABC transporter; Region: ABC_tran_2; pfam12848 869729013956 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869729013957 lytic murein transglycosylase; Provisional; Region: PRK11619 869729013958 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 869729013959 N-acetyl-D-glucosamine binding site [chemical binding]; other site 869729013960 catalytic residue [active] 869729013961 Trp operon repressor; Provisional; Region: PRK01381 869729013962 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 869729013963 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869729013964 catalytic core [active] 869729013965 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 869729013966 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729013967 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 869729013968 hypothetical protein; Provisional; Region: PRK10756 869729013969 CreA protein; Region: CreA; pfam05981 869729013970 DNA-binding response regulator CreB; Provisional; Region: PRK11083 869729013971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729013972 active site 869729013973 phosphorylation site [posttranslational modification] 869729013974 intermolecular recognition site; other site 869729013975 dimerization interface [polypeptide binding]; other site 869729013976 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869729013977 DNA binding site [nucleotide binding] 869729013978 sensory histidine kinase CreC; Provisional; Region: PRK11100 869729013979 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869729013980 dimerization interface [polypeptide binding]; other site 869729013981 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869729013982 dimer interface [polypeptide binding]; other site 869729013983 phosphorylation site [posttranslational modification] 869729013984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869729013985 ATP binding site [chemical binding]; other site 869729013986 Mg2+ binding site [ion binding]; other site 869729013987 G-X-G motif; other site 869729013988 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 869729013989 two-component response regulator; Provisional; Region: PRK11173 869729013990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869729013991 active site 869729013992 phosphorylation site [posttranslational modification] 869729013993 intermolecular recognition site; other site 869729013994 dimerization interface [polypeptide binding]; other site 869729013995 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869729013996 DNA binding site [nucleotide binding] 869729013997 putative RNA methyltransferase; Provisional; Region: PRK10433 869729013998 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 869729013999 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 869729014000 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 869729014001 putative catalytic residues [active] 869729014002 putative nucleotide binding site [chemical binding]; other site 869729014003 putative aspartate binding site [chemical binding]; other site 869729014004 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 869729014005 dimer interface [polypeptide binding]; other site 869729014006 putative threonine allosteric regulatory site; other site 869729014007 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 869729014008 putative threonine allosteric regulatory site; other site 869729014009 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 869729014010 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 869729014011 homoserine kinase; Region: thrB; TIGR00191 869729014012 Protein of unknown function; Region: YhfT; pfam10797 869729014013 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 869729014014 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 869729014015 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 869729014016 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729014017 catalytic residue [active] 869729014018 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 869729014019 hypothetical protein; Validated; Region: PRK02101 869729014020 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 869729014021 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 869729014022 transaldolase-like protein; Provisional; Region: PTZ00411 869729014023 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 869729014024 active site 869729014025 dimer interface [polypeptide binding]; other site 869729014026 catalytic residue [active] 869729014027 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 869729014028 MPT binding site; other site 869729014029 trimer interface [polypeptide binding]; other site 869729014030 hypothetical protein; Provisional; Region: PRK10659 869729014031 hypothetical protein; Provisional; Region: PRK10236 869729014032 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 869729014033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 869729014034 hypothetical protein; Provisional; Region: PRK10154 869729014035 potential protein location (hypothetical protein) that overlaps protein (molecular chaperone DnaK) 869729014036 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 869729014037 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 869729014038 nucleotide binding site [chemical binding]; other site 869729014039 NEF interaction site [polypeptide binding]; other site 869729014040 SBD interface [polypeptide binding]; other site 869729014041 chaperone protein DnaJ; Provisional; Region: PRK10767 869729014042 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 869729014043 HSP70 interaction site [polypeptide binding]; other site 869729014044 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 869729014045 substrate binding site [polypeptide binding]; other site 869729014046 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 869729014047 Zn binding sites [ion binding]; other site 869729014048 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 869729014049 dimer interface [polypeptide binding]; other site 869729014050 Hok/gef family; Region: HOK_GEF; pfam01848 869729014051 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 869729014052 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 869729014053 Sulfatase; Region: Sulfatase; pfam00884 869729014054 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 869729014055 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 869729014056 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729014057 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 869729014058 putative dimerization interface [polypeptide binding]; other site 869729014059 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 869729014060 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 869729014061 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 869729014062 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 869729014063 active site 869729014064 Riboflavin kinase; Region: Flavokinase; smart00904 869729014065 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 869729014066 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 869729014067 HIGH motif; other site 869729014068 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 869729014069 active site 869729014070 KMSKS motif; other site 869729014071 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 869729014072 tRNA binding surface [nucleotide binding]; other site 869729014073 anticodon binding site; other site 869729014074 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 869729014075 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 869729014076 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 869729014077 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 869729014078 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 869729014079 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 869729014080 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 869729014081 active site 869729014082 tetramer interface [polypeptide binding]; other site 869729014083 Protein of unknown function (DUF805); Region: DUF805; pfam05656 869729014084 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 869729014085 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 869729014086 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 869729014087 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 869729014088 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 869729014089 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 869729014090 catalytic site [active] 869729014091 subunit interface [polypeptide binding]; other site 869729014092 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 869729014093 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 869729014094 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 869729014095 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 869729014096 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 869729014097 ATP-grasp domain; Region: ATP-grasp_4; cl17255 869729014098 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 869729014099 IMP binding site; other site 869729014100 dimer interface [polypeptide binding]; other site 869729014101 interdomain contacts; other site 869729014102 partial ornithine binding site; other site 869729014103 Transposase IS200 like; Region: Y1_Tnp; pfam01797 869729014104 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 869729014105 carnitine operon protein CaiE; Provisional; Region: PRK13627 869729014106 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 869729014107 putative trimer interface [polypeptide binding]; other site 869729014108 putative metal binding site [ion binding]; other site 869729014109 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 869729014110 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 869729014111 substrate binding site [chemical binding]; other site 869729014112 oxyanion hole (OAH) forming residues; other site 869729014113 trimer interface [polypeptide binding]; other site 869729014114 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 869729014115 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 869729014116 acyl-activating enzyme (AAE) consensus motif; other site 869729014117 putative AMP binding site [chemical binding]; other site 869729014118 putative active site [active] 869729014119 putative CoA binding site [chemical binding]; other site 869729014120 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 869729014121 CoA-transferase family III; Region: CoA_transf_3; pfam02515 869729014122 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 869729014123 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 869729014124 active site 869729014125 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 869729014126 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 869729014127 Ligand binding site [chemical binding]; other site 869729014128 Electron transfer flavoprotein domain; Region: ETF; pfam01012 869729014129 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 869729014130 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 869729014131 Ligand binding site [chemical binding]; other site 869729014132 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 869729014133 putative oxidoreductase FixC; Provisional; Region: PRK10157 869729014134 ferredoxin-like protein FixX; Provisional; Region: PRK15449 869729014135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869729014136 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 869729014137 putative substrate translocation pore; other site 869729014138 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 869729014139 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 869729014140 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 869729014141 TrkA-N domain; Region: TrkA_N; pfam02254 869729014142 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 869729014143 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 869729014144 folate binding site [chemical binding]; other site 869729014145 NADP+ binding site [chemical binding]; other site 869729014146 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 869729014147 CcdB protein; Region: CcdB; cl03380 869729014148 CcdB protein; Region: CcdB; cl03380 869729014149 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 869729014150 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 869729014151 active site 869729014152 metal binding site [ion binding]; metal-binding site 869729014153 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 869729014154 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 869729014155 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 869729014156 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 869729014157 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 869729014158 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 869729014159 SurA N-terminal domain; Region: SurA_N; pfam09312 869729014160 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 869729014161 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 869729014162 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 869729014163 OstA-like protein; Region: OstA; pfam03968 869729014164 Organic solvent tolerance protein; Region: OstA_C; pfam04453 869729014165 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 869729014166 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 869729014167 putative metal binding site [ion binding]; other site 869729014168 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 869729014169 HSP70 interaction site [polypeptide binding]; other site 869729014170 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 869729014171 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 869729014172 active site 869729014173 ATP-dependent helicase HepA; Validated; Region: PRK04914 869729014174 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869729014175 ATP binding site [chemical binding]; other site 869729014176 putative Mg++ binding site [ion binding]; other site 869729014177 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869729014178 nucleotide binding region [chemical binding]; other site 869729014179 ATP-binding site [chemical binding]; other site 869729014180 DNA polymerase II; Reviewed; Region: PRK05762 869729014181 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 869729014182 active site 869729014183 catalytic site [active] 869729014184 substrate binding site [chemical binding]; other site 869729014185 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 869729014186 active site 869729014187 metal-binding site 869729014188 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 869729014189 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 869729014190 intersubunit interface [polypeptide binding]; other site 869729014191 active site 869729014192 Zn2+ binding site [ion binding]; other site 869729014193 L-arabinose isomerase; Provisional; Region: PRK02929 869729014194 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 869729014195 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 869729014196 trimer interface [polypeptide binding]; other site 869729014197 putative substrate binding site [chemical binding]; other site 869729014198 putative metal binding site [ion binding]; other site 869729014199 ribulokinase; Provisional; Region: PRK04123 869729014200 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 869729014201 N- and C-terminal domain interface [polypeptide binding]; other site 869729014202 active site 869729014203 MgATP binding site [chemical binding]; other site 869729014204 catalytic site [active] 869729014205 metal binding site [ion binding]; metal-binding site 869729014206 carbohydrate binding site [chemical binding]; other site 869729014207 homodimer interface [polypeptide binding]; other site 869729014208 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 869729014209 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 869729014210 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729014211 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869729014212 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 869729014213 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 869729014214 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 869729014215 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 869729014216 Walker A/P-loop; other site 869729014217 ATP binding site [chemical binding]; other site 869729014218 Q-loop/lid; other site 869729014219 ABC transporter signature motif; other site 869729014220 Walker B; other site 869729014221 D-loop; other site 869729014222 H-loop/switch region; other site 869729014223 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 869729014224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729014225 dimer interface [polypeptide binding]; other site 869729014226 conserved gate region; other site 869729014227 putative PBP binding loops; other site 869729014228 ABC-ATPase subunit interface; other site 869729014229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729014230 dimer interface [polypeptide binding]; other site 869729014231 conserved gate region; other site 869729014232 putative PBP binding loops; other site 869729014233 ABC-ATPase subunit interface; other site 869729014234 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 869729014235 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 869729014236 transcriptional regulator SgrR; Provisional; Region: PRK13626 869729014237 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 869729014238 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 869729014239 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 869729014240 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 869729014241 substrate binding site [chemical binding]; other site 869729014242 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 869729014243 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 869729014244 substrate binding site [chemical binding]; other site 869729014245 ligand binding site [chemical binding]; other site 869729014246 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 869729014247 tartrate dehydrogenase; Region: TTC; TIGR02089 869729014248 2-isopropylmalate synthase; Validated; Region: PRK00915 869729014249 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 869729014250 active site 869729014251 catalytic residues [active] 869729014252 metal binding site [ion binding]; metal-binding site 869729014253 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 869729014254 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 869729014255 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869729014256 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 869729014257 putative substrate binding pocket [chemical binding]; other site 869729014258 putative dimerization interface [polypeptide binding]; other site 869729014259 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 869729014260 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 869729014261 PYR/PP interface [polypeptide binding]; other site 869729014262 dimer interface [polypeptide binding]; other site 869729014263 TPP binding site [chemical binding]; other site 869729014264 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 869729014265 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 869729014266 TPP-binding site [chemical binding]; other site 869729014267 dimer interface [polypeptide binding]; other site 869729014268 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 869729014269 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 869729014270 putative valine binding site [chemical binding]; other site 869729014271 dimer interface [polypeptide binding]; other site 869729014272 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 869729014273 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 869729014274 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869729014275 DNA binding site [nucleotide binding] 869729014276 domain linker motif; other site 869729014277 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 869729014278 dimerization interface [polypeptide binding]; other site 869729014279 ligand binding site [chemical binding]; other site 869729014280 mraZ protein; Region: TIGR00242 869729014281 MraZ protein; Region: MraZ; pfam02381 869729014282 MraZ protein; Region: MraZ; pfam02381 869729014283 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 869729014284 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 869729014285 cell division protein FtsL; Provisional; Region: PRK10772 869729014286 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 869729014287 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 869729014288 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 869729014289 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 869729014290 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 869729014291 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869729014292 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869729014293 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 869729014294 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 869729014295 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869729014296 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869729014297 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 869729014298 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 869729014299 Mg++ binding site [ion binding]; other site 869729014300 putative catalytic motif [active] 869729014301 putative substrate binding site [chemical binding]; other site 869729014302 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 869729014303 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869729014304 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869729014305 cell division protein FtsW; Provisional; Region: PRK10774 869729014306 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 869729014307 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 869729014308 active site 869729014309 homodimer interface [polypeptide binding]; other site 869729014310 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 869729014311 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 869729014312 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869729014313 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869729014314 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 869729014315 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 869729014316 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 869729014317 cell division protein FtsQ; Provisional; Region: PRK10775 869729014318 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 869729014319 Cell division protein FtsQ; Region: FtsQ; pfam03799 869729014320 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 869729014321 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 869729014322 Cell division protein FtsA; Region: FtsA; pfam14450 869729014323 cell division protein FtsZ; Validated; Region: PRK09330 869729014324 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 869729014325 nucleotide binding site [chemical binding]; other site 869729014326 SulA interaction site; other site 869729014327 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 869729014328 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 869729014329 SecA regulator SecM; Provisional; Region: PRK02943 869729014330 potential frameshift: common BLAST hit: gi|291280923|ref|YP_003497741.1| preprotein translocase subunit SecA 869729014331 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 869729014332 active site 869729014333 8-oxo-dGMP binding site [chemical binding]; other site 869729014334 nudix motif; other site 869729014335 metal binding site [ion binding]; metal-binding site 869729014336 DNA gyrase inhibitor; Reviewed; Region: PRK00418 869729014337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 869729014338 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 869729014339 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 869729014340 CoA-binding site [chemical binding]; other site 869729014341 ATP-binding [chemical binding]; other site 869729014342 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 869729014343 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 869729014344 active site 869729014345 type IV pilin biogenesis protein; Provisional; Region: PRK10573 869729014346 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 869729014347 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 869729014348 hypothetical protein; Provisional; Region: PRK10436 869729014349 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 869729014350 Walker A motif; other site 869729014351 ATP binding site [chemical binding]; other site 869729014352 Walker B motif; other site 869729014353 putative major pilin subunit; Provisional; Region: PRK10574 869729014354 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 869729014355 Pilin (bacterial filament); Region: Pilin; pfam00114 869729014356 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 869729014357 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 869729014358 dimerization interface [polypeptide binding]; other site 869729014359 active site 869729014360 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 869729014361 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 869729014362 amidase catalytic site [active] 869729014363 Zn binding residues [ion binding]; other site 869729014364 substrate binding site [chemical binding]; other site 869729014365 regulatory protein AmpE; Provisional; Region: PRK10987 869729014366 aromatic amino acid transporter; Provisional; Region: PRK10238 869729014367 Protein of unknown function (DUF796); Region: DUF796; cl01226 869729014368 S-type Pyocin; Region: Pyocin_S; pfam06958 869729014369 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 869729014370 active site 869729014371 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 869729014372 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 869729014373 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 869729014374 Transcriptional regulators [Transcription]; Region: FadR; COG2186 869729014375 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869729014376 DNA-binding site [nucleotide binding]; DNA binding site 869729014377 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 869729014378 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 869729014379 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 869729014380 dimer interface [polypeptide binding]; other site 869729014381 TPP-binding site [chemical binding]; other site 869729014382 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 869729014383 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 869729014384 E3 interaction surface; other site 869729014385 lipoyl attachment site [posttranslational modification]; other site 869729014386 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 869729014387 E3 interaction surface; other site 869729014388 lipoyl attachment site [posttranslational modification]; other site 869729014389 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 869729014390 E3 interaction surface; other site 869729014391 lipoyl attachment site [posttranslational modification]; other site 869729014392 e3 binding domain; Region: E3_binding; pfam02817 869729014393 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 869729014394 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 869729014395 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 869729014396 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869729014397 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 869729014398 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 869729014399 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 869729014400 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 869729014401 substrate binding site [chemical binding]; other site 869729014402 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 869729014403 substrate binding site [chemical binding]; other site 869729014404 ligand binding site [chemical binding]; other site 869729014405 hypothetical protein; Provisional; Region: PRK05248 869729014406 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 869729014407 spermidine synthase; Provisional; Region: PRK00811 869729014408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869729014409 S-adenosylmethionine binding site [chemical binding]; other site 869729014410 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 869729014411 multicopper oxidase; Provisional; Region: PRK10965 869729014412 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 869729014413 Multicopper oxidase; Region: Cu-oxidase; pfam00394 869729014414 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 869729014415 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 869729014416 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 869729014417 Trp docking motif [polypeptide binding]; other site 869729014418 putative active site [active] 869729014419 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869729014420 active site 869729014421 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 869729014422 active site clefts [active] 869729014423 zinc binding site [ion binding]; other site 869729014424 dimer interface [polypeptide binding]; other site 869729014425 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 869729014426 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869729014427 Walker A/P-loop; other site 869729014428 ATP binding site [chemical binding]; other site 869729014429 Q-loop/lid; other site 869729014430 ABC transporter signature motif; other site 869729014431 Walker B; other site 869729014432 D-loop; other site 869729014433 H-loop/switch region; other site 869729014434 inner membrane transport permease; Provisional; Region: PRK15066 869729014435 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 869729014436 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 869729014437 active pocket/dimerization site; other site 869729014438 active site 869729014439 phosphorylation site [posttranslational modification] 869729014440 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 869729014441 putative active site [active] 869729014442 putative metal binding site [ion binding]; other site 869729014443 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 869729014444 tetramerization interface [polypeptide binding]; other site 869729014445 active site 869729014446 Uncharacterized conserved protein [Function unknown]; Region: COG5464 869729014447 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 869729014448 pantoate--beta-alanine ligase; Region: panC; TIGR00018 869729014449 Pantoate-beta-alanine ligase; Region: PanC; cd00560 869729014450 active site 869729014451 ATP-binding site [chemical binding]; other site 869729014452 pantoate-binding site; other site 869729014453 HXXH motif; other site 869729014454 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 869729014455 oligomerization interface [polypeptide binding]; other site 869729014456 active site 869729014457 metal binding site [ion binding]; metal-binding site 869729014458 putative fimbrial-like adhesin protein; Provisional; Region: PRK09723 869729014459 putative fimbrial protein StaF; Provisional; Region: PRK15262 869729014460 putative fimbrial protein StaE; Provisional; Region: PRK15263 869729014461 Fimbrial protein; Region: Fimbrial; cl01416 869729014462 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 869729014463 PapC N-terminal domain; Region: PapC_N; pfam13954 869729014464 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 869729014465 PapC C-terminal domain; Region: PapC_C; pfam13953 869729014466 putative chaperone protein EcpD; Provisional; Region: PRK09926 869729014467 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 869729014468 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 869729014469 Fimbrial protein; Region: Fimbrial; cl01416 869729014470 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 869729014471 catalytic center binding site [active] 869729014472 ATP binding site [chemical binding]; other site 869729014473 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 869729014474 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 869729014475 active site 869729014476 NTP binding site [chemical binding]; other site 869729014477 metal binding triad [ion binding]; metal-binding site 869729014478 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 869729014479 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 869729014480 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 869729014481 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 869729014482 active site 869729014483 nucleotide binding site [chemical binding]; other site 869729014484 HIGH motif; other site 869729014485 KMSKS motif; other site 869729014486 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 869729014487 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 869729014488 2'-5' RNA ligase; Provisional; Region: PRK15124 869729014489 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 869729014490 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 869729014491 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 869729014492 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869729014493 ATP binding site [chemical binding]; other site 869729014494 putative Mg++ binding site [ion binding]; other site 869729014495 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869729014496 nucleotide binding region [chemical binding]; other site 869729014497 ATP-binding site [chemical binding]; other site 869729014498 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 869729014499 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 869729014500 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 869729014501 Transglycosylase; Region: Transgly; pfam00912 869729014502 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 869729014503 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 869729014504 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 869729014505 N-terminal plug; other site 869729014506 ligand-binding site [chemical binding]; other site 869729014507 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 869729014508 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 869729014509 Walker A/P-loop; other site 869729014510 ATP binding site [chemical binding]; other site 869729014511 Q-loop/lid; other site 869729014512 ABC transporter signature motif; other site 869729014513 Walker B; other site 869729014514 D-loop; other site 869729014515 H-loop/switch region; other site 869729014516 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 869729014517 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 869729014518 siderophore binding site; other site 869729014519 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 869729014520 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869729014521 ABC-ATPase subunit interface; other site 869729014522 dimer interface [polypeptide binding]; other site 869729014523 putative PBP binding regions; other site 869729014524 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869729014525 ABC-ATPase subunit interface; other site 869729014526 dimer interface [polypeptide binding]; other site 869729014527 putative PBP binding regions; other site 869729014528 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 869729014529 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 869729014530 inhibitor-cofactor binding pocket; inhibition site 869729014531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729014532 catalytic residue [active] 869729014533 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 869729014534 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 869729014535 Cl- selectivity filter; other site 869729014536 Cl- binding residues [ion binding]; other site 869729014537 pore gating glutamate residue; other site 869729014538 dimer interface [polypeptide binding]; other site 869729014539 H+/Cl- coupling transport residue; other site 869729014540 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 869729014541 hypothetical protein; Provisional; Region: PRK10578 869729014542 UPF0126 domain; Region: UPF0126; pfam03458 869729014543 UPF0126 domain; Region: UPF0126; pfam03458 869729014544 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 869729014545 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 869729014546 cobalamin binding residues [chemical binding]; other site 869729014547 putative BtuC binding residues; other site 869729014548 dimer interface [polypeptide binding]; other site 869729014549 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 869729014550 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 869729014551 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 869729014552 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869729014553 Zn2+ binding site [ion binding]; other site 869729014554 Mg2+ binding site [ion binding]; other site 869729014555 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 869729014556 serine endoprotease; Provisional; Region: PRK10942 869729014557 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 869729014558 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 869729014559 protein binding site [polypeptide binding]; other site 869729014560 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 869729014561 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 869729014562 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 869729014563 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 869729014564 hypothetical protein; Provisional; Region: PRK13677 869729014565 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 869729014566 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 869729014567 trimer interface [polypeptide binding]; other site 869729014568 active site 869729014569 substrate binding site [chemical binding]; other site 869729014570 CoA binding site [chemical binding]; other site 869729014571 PII uridylyl-transferase; Provisional; Region: PRK05007 869729014572 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 869729014573 metal binding triad; other site 869729014574 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 869729014575 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869729014576 Zn2+ binding site [ion binding]; other site 869729014577 Mg2+ binding site [ion binding]; other site 869729014578 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 869729014579 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 869729014580 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 869729014581 active site 869729014582 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 869729014583 rRNA interaction site [nucleotide binding]; other site 869729014584 S8 interaction site; other site 869729014585 putative laminin-1 binding site; other site 869729014586 elongation factor Ts; Provisional; Region: tsf; PRK09377 869729014587 UBA/TS-N domain; Region: UBA; pfam00627 869729014588 Elongation factor TS; Region: EF_TS; pfam00889 869729014589 Elongation factor TS; Region: EF_TS; pfam00889 869729014590 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 869729014591 putative nucleotide binding site [chemical binding]; other site 869729014592 uridine monophosphate binding site [chemical binding]; other site 869729014593 homohexameric interface [polypeptide binding]; other site 869729014594 ribosome recycling factor; Reviewed; Region: frr; PRK00083 869729014595 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 869729014596 hinge region; other site 869729014597 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 869729014598 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 869729014599 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 869729014600 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 869729014601 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 869729014602 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 869729014603 catalytic residue [active] 869729014604 putative FPP diphosphate binding site; other site 869729014605 putative FPP binding hydrophobic cleft; other site 869729014606 dimer interface [polypeptide binding]; other site 869729014607 putative IPP diphosphate binding site; other site 869729014608 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 869729014609 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 869729014610 zinc metallopeptidase RseP; Provisional; Region: PRK10779 869729014611 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 869729014612 active site 869729014613 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 869729014614 protein binding site [polypeptide binding]; other site 869729014615 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 869729014616 putative substrate binding region [chemical binding]; other site 869729014617 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 869729014618 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 869729014619 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 869729014620 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 869729014621 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 869729014622 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 869729014623 Surface antigen; Region: Bac_surface_Ag; pfam01103 869729014624 periplasmic chaperone; Provisional; Region: PRK10780 869729014625 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 869729014626 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 869729014627 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 869729014628 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 869729014629 trimer interface [polypeptide binding]; other site 869729014630 active site 869729014631 UDP-GlcNAc binding site [chemical binding]; other site 869729014632 lipid binding site [chemical binding]; lipid-binding site 869729014633 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 869729014634 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 869729014635 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 869729014636 active site 869729014637 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 869729014638 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 869729014639 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 869729014640 RNA/DNA hybrid binding site [nucleotide binding]; other site 869729014641 active site 869729014642 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 869729014643 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 869729014644 putative active site [active] 869729014645 putative PHP Thumb interface [polypeptide binding]; other site 869729014646 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 869729014647 generic binding surface II; other site 869729014648 generic binding surface I; other site 869729014649 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 869729014650 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 869729014651 lysine decarboxylase LdcC; Provisional; Region: PRK15399 869729014652 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 869729014653 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 869729014654 homodimer interface [polypeptide binding]; other site 869729014655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869729014656 catalytic residue [active] 869729014657 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 869729014658 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 869729014659 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 869729014660 putative metal binding site [ion binding]; other site 869729014661 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 869729014662 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 869729014663 Ligand Binding Site [chemical binding]; other site 869729014664 TilS substrate binding domain; Region: TilS; pfam09179 869729014665 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 869729014666 Rho-binding antiterminator; Provisional; Region: PRK11625 869729014667 hypothetical protein; Provisional; Region: PRK04964 869729014668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 869729014669 hypothetical protein; Provisional; Region: PRK09256 869729014670 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 869729014671 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 869729014672 NlpE N-terminal domain; Region: NlpE; pfam04170 869729014673 hypothetical protein; Provisional; Region: PRK11479 869729014674 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 869729014675 prolyl-tRNA synthetase; Provisional; Region: PRK09194 869729014676 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 869729014677 dimer interface [polypeptide binding]; other site 869729014678 motif 1; other site 869729014679 active site 869729014680 motif 2; other site 869729014681 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 869729014682 putative deacylase active site [active] 869729014683 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 869729014684 active site 869729014685 motif 3; other site 869729014686 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 869729014687 anticodon binding site; other site 869729014688 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 869729014689 homodimer interaction site [polypeptide binding]; other site 869729014690 cofactor binding site; other site 869729014691 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 869729014692 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 869729014693 lipoprotein, YaeC family; Region: TIGR00363 869729014694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869729014695 dimer interface [polypeptide binding]; other site 869729014696 conserved gate region; other site 869729014697 ABC-ATPase subunit interface; other site 869729014698 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 869729014699 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 869729014700 Walker A/P-loop; other site 869729014701 ATP binding site [chemical binding]; other site 869729014702 Q-loop/lid; other site 869729014703 ABC transporter signature motif; other site 869729014704 Walker B; other site 869729014705 D-loop; other site 869729014706 H-loop/switch region; other site 869729014707 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 869729014708 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 869729014709 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869729014710 active site 869729014711 motif I; other site 869729014712 motif II; other site