-- dump date   	20140619_091242
-- class       	Genbank::CDS
-- table       	cds_note
-- id	note
YP_538602.1	RepA6
YP_538603.1	RepA
YP_538605.1	tnIS26
YP_538608.1	uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm
YP_538643.3	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_538656.1	controlled cell death protein; post-segregation toxin; toxin addiction system
YP_538695.1	PsiA
YP_538696.1	Mok; similar to F leading maintenance protein C
YP_538716.1	similar to VirB4
YP_538722.1	TraN; TrhN; involved in stabilizing mating pairs during plasmid conjugation; F plasmid TraN appears to recognize OmpA in the recipient cell
YP_538724.1	type IV secretion system pilus assembly protein; similar to F plasmid TraF
YP_538736.1	type IV secretion system coupling protein; similar to F plasmid TraD
YP_538737.1	cleaves origin of transfer and unwinds; oriT relaxase
YP_539042.1	involved in threonine biosynthesis; controls the expression of the thrLABC operon
YP_539043.1	multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways
YP_539044.1	catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate
YP_539045.1	catalyzes the formation of L-threonine from O-phospho-L-homoserine
YP_539051.1	forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis
YP_539057.1	heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria
YP_539058.1	chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion
YP_539063.1	exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH
YP_539064.2	Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC
YP_539066.1	binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase
YP_539068.1	catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities
YP_539069.1	IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 1 subfamily; some organisms carry two different copies of this enzyme
YP_539070.1	lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis
YP_539072.1	catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway
YP_539073.1	catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides
YP_539075.1	catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis
YP_539077.1	catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers
YP_539078.1	four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity
YP_539081.2	regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons
YP_539082.1	involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities
YP_539083.1	catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA
YP_539085.1	catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine
YP_539086.1	catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA
YP_539087.1	catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism
YP_539088.2	required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase
YP_539089.1	involved in electron transfer during carnitine metabolism
YP_539090.1	FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction
YP_539093.1	Required for full activity of KefC, a potassium-proton antiporter
YP_539094.1	transport system that facilitates potassium-efflux
YP_539095.1	catalyzes the reduction of dihydrofolate to tetrahydrofolate
YP_539097.1	hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP
YP_539098.1	protein associated with Co2+ and Mg2+ efflux
YP_539099.1	catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin
YP_539100.1	catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate)
YP_539101.1	Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB
YP_539102.1	determines N-hexane tolerance and is involved in outer membrane permeability
YP_539103.2	functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system
YP_539104.1	catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs
YP_539105.1	transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA
YP_539106.1	Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C
YP_539107.1	catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source
YP_539108.1	catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism
YP_539109.1	catalyzes the phosphorylation of ribulose to ribulose 5-phosphate
YP_539110.1	positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose
YP_539115.1	with TbpA and ThiP is part of the thiamine and TPP transport system
YP_539116.1	permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine
YP_539117.2	part of the thiamine and TPP transport system tbpA-thiPQ
YP_539118.1	activates sgrS under glucose-phosphate stress conditions
YP_539119.1	catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D
YP_539120.1	dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate
YP_539121.1	catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis
YP_539122.1	catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis
YP_539123.1	involved in attenuation control of the leuABCD operon in leucine biosynthesis
YP_539125.1	activator for leuABCD operon; member of LysR family of transcriptional activators
YP_539126.2	catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive
YP_539127.2	with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit
YP_539130.1	binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism
YP_539131.1	MraZ; UPF0040; crystal structure shows similarity to AbrB
YP_539132.1	yabC, orfB
YP_539133.1	membrane bound cell division protein at septum containing leucine zipper motif
YP_539135.1	involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate
YP_539137.1	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YP_539138.1	UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation
YP_539139.1	integral membrane protein involved in stabilizing FstZ ring during cell division
YP_539140.1	UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis
YP_539141.1	Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis
YP_539142.1	D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli
YP_539143.1	involved in septum formation
YP_539144.1	ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane
YP_539145.1	GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function
YP_539146.1	zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis
YP_539147.2	secM translational pause allows for the initiation of secA translation
YP_539148.1	functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins
YP_539152.1	catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis
YP_539153.1	catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate
YP_539158.2	catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide
YP_539160.1	involved in regulation of beta-lactamase; signaling protein
YP_539166.2	activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex
YP_539168.1	E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC
YP_539169.1	E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains
YP_539170.2	E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide
YP_539172.2	catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate
YP_539174.1	S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine
YP_539175.1	catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine
YP_539177.2	laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification
YP_539180.1	catalyzes the interconversion of bicarbonate and carbon dioxide
YP_539185.1	Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5)
YP_539188.1	catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine
YP_539189.1	catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate
YP_539194.1	similar to the fimbrial usher protein PapC
YP_539197.1	catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP
YP_539198.1	Polymerase that creates the 3' poly(A) tail found in some mRNA's
YP_539199.2	this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu
YP_539201.1	Regulatory factor involved in maltose metabolism
YP_539203.1	similar in sequence to the ATP-dependent RNA helicase HrpA
YP_539205.1	bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell
YP_539207.1	involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein
YP_539208.2	part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter
YP_539209.1	Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores
YP_539210.1	part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome
YP_539211.1	Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway
YP_539212.1	Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation
YP_539213.1	essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors
YP_539215.1	solute binding component of the vitamin B12 transport system BtuCDF
YP_539216.1	enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine
YP_539217.1	forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate
YP_539218.1	protease Do; required at high temperature; degrades damaged proteins
YP_539219.1	regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization
YP_539221.1	catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway
YP_539222.1	catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein
YP_539223.1	catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn
YP_539224.2	one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit
YP_539226.1	EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu
YP_539227.1	Catalyzes the phosphorylation of UMP to UDP
YP_539228.1	Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs
YP_539229.1	catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate
YP_539230.1	catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate
YP_539231.1	catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate
YP_539232.1	catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response
YP_539233.1	part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins
YP_539235.1	adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis
YP_539236.1	in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP
YP_539237.1	catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis
YP_539238.1	catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM
YP_539239.1	RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids
YP_539240.1	catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase
YP_539241.1	catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein
YP_539244.1	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase
YP_539245.1	Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination
YP_539251.2	catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro)
YP_539255.1	part of the MetNIQ methionine uptake system
YP_539256.1	part of the metNIQ transport system for methionine
YP_539257.1	Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate
YP_539261.1	catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid
YP_539265.1	catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall
YP_539266.1	catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione
YP_539268.1	An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids
YP_539269.1	3'-5' exonuclease of DNA polymerase III
YP_539294.1	inactivates vertebrate C-type lysozyme
YP_539295.2	functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA
YP_539296.2	catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate
YP_539305.1	involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function
YP_539307.1	YafO overproduction induces toxicity; it is believed to be the toxin of a toxin-antitoxin pair; unknown function
YP_539309.1	mutations in this gene result in a compromised ability for drug-inducible mexXY expression; expression is inducible by the same ribosome-targeting agents that induce mexXY
YP_539310.2	similar to release factor 1 and 2
YP_539312.1	catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively
YP_539314.1	forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation
YP_539315.1	involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS
YP_539317.2	catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis
YP_539318.1	Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway
YP_539321.1	similar to pathogenesis-related protein
YP_539345.1	smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif
YP_539346.2	RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome
YP_539359.2	Involved in disulfide oxidoreductase activity and electron transport
YP_539372.2	catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine
YP_539373.1	catalyzes the formation of betaine from betaine aldehyde
YP_539374.1	HTH-type; bet1; Repressor involved in choline regulation of the bet genes
YP_539375.1	proton-motive-force-driven choline transporter
YP_539385.1	metallo-dependent hydrolase superfamily; deaminase with metallo-dependent hydrolase domain
YP_539395.1	catalyzes the formation of pyruvate and succinate from 2-methylisocitrate
YP_539396.1	catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity
YP_539397.1	functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C
YP_539398.1	catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent
YP_539400.1	Catalyzes the deamination of cytosine to uracil and ammonia
YP_539401.1	transfers acetyl group from acetyl-CoA to the 6-hydroxyl of galactopyranosides; exact physiological role is unknown
YP_539402.1	lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments
YP_539403.1	forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon
YP_539404.1	transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer
YP_539409.1	formaldehyde-induced negative regulator of the frmRAB operon
YP_539416.2	with TauB and TauC is responsible for taurine uptake.
YP_539417.1	Part of the ABC transporter complex tauABC involved in taurine import
YP_539419.1	catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers
YP_539420.1	catalyzes the formation of porphobilinogen from 5-aminolevulinate
YP_539423.1	this protein has no known enzymatic function
YP_539425.1	in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope
YP_539430.1	D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli
YP_539436.1	catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis
YP_539437.2	catalyzes the formation of L-proline from pyrroline-5-carboxylate
YP_539439.1	type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis
YP_539446.2	Required for efficient pilin antigenic variation
YP_539447.2	catalyzes phosphorylation of fructose; cytosolic enzyme
YP_539448.1	member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers
YP_539449.1	with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity
YP_539450.1	with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity
YP_539452.1	two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB
YP_539453.1	membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB
YP_539456.1	cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation
YP_539458.2	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
YP_539459.1	Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step
YP_539460.1	Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr)
YP_539461.2	member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex
YP_539462.1	part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane
YP_539463.1	forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF
YP_539468.1	riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil
YP_539469.2	RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not
YP_539471.1	Regulates rRNA biosynthesis by transcriptional antitermination
YP_539472.1	catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP
YP_539473.1	hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate
YP_539475.1	catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate
YP_539477.1	catalyzes the bidirectional exonucleolytic cleavage of DNA
YP_539478.1	Required for the synthesis of the thiazole moiety
YP_539480.1	ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis
YP_539481.1	nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription
YP_539483.1	converts protoheme IX and farnesyl diphosphate to heme O
YP_539489.1	in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein
YP_539492.2	positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress
YP_539495.1	Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer
YP_539497.1	hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates
YP_539498.1	binds and unfolds substrates as part of the ClpXP protease
YP_539500.1	histone-like DNA-binding protein
YP_539504.1	YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His
YP_539510.1	indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia.
YP_539519.1	with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins
YP_539523.1	regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine
YP_539524.1	small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS
YP_539526.1	PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks
YP_539528.1	catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis
YP_539529.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA
YP_539532.1	involved in a recombinational process of DNA repair, independent of the recBC complex
YP_539533.1	molecular chaperone
YP_539534.1	essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP
YP_539535.1	protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic
YP_539538.1	YbaL; member of the CPA-2 family of antiporters; uncharacterized protein
YP_539540.1	catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides
YP_539548.1	catalyzes the formation of glutamate from glutamine
YP_539550.1	activator of copper-responsive regulon genes
YP_539564.1	catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
YP_539565.1	activator of the allDC-ylbA operon involved in allantoin utilization
YP_539566.1	catalyzes the formation of glyoxylate from (S)-ureidoglycolate
YP_539567.1	regulates operons involved in the utilization of allantoin
YP_539568.2	catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate
YP_539572.1	Plays a crucial role on both purine and pyrimidine metabolism
YP_539576.1	allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide
YP_539578.1	multicopy suppressor of dominant negative ftsH mutations
YP_539582.1	With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway
YP_539585.1	catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine
YP_539587.1	catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA
YP_539591.1	catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate
YP_539597.1	outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA
YP_539602.1	response regulator in two-component regulatory system with CusS; regulates the copper efflux system
YP_539603.1	with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver
YP_539605.1	with CusA, CusC and CusF is part of a cation efflux system that mediates resistance to copper and silver
YP_539609.1	catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive
YP_539612.1	ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity
YP_539615.1	Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space
YP_539619.1	with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin
YP_539620.1	part of the ferric enterobactin transport system; necessary for enetrobactin uptake
YP_539621.1	with FepBDE is involved in the transport of ferric enterobactin
YP_539622.1	with FepBCD is involved in the transport of ferric enterobactin
YP_539623.1	with FepBCG is involved in the transport of ferric enterobactin
YP_539624.1	protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters
YP_539625.1	with FepCDG is involved in the transport of ferric enterobactin
YP_539627.1	bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate
YP_539629.1	catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin
YP_539633.1	member of the iron-containing alcohol dehydrogenase; unknown function
YP_539634.1	catalyzes the transfer of an amino moiety
YP_539638.2	Involved in disulfide bond formation
YP_539639.1	with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate
YP_539643.1	Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation
YP_539646.1	catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA
YP_539647.1	2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate
YP_539652.1	acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate
YP_539655.1	regulates the expression of citAB in citrate fermentation
YP_539656.1	responsible for the transport of C4-dicarboxylates during anaerobic growth
YP_539657.1	catalyzes the transfer of palmitate to lipid A
YP_539658.1	member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator
YP_539659.1	may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling
YP_539661.1	TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes
YP_539662.1	catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group
YP_539663.1	lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein
YP_539665.1	penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors
YP_539669.1	SPOUT methyltransferase; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA
YP_539673.1	transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria
YP_539674.1	required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA
YP_539675.1	rare lipoprotein B; involved in the assembly of LPS in the outer membrane
YP_539676.1	leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase
YP_539678.2	Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific
YP_539686.1	Transfers the fatty acyl group on membrane lipoproteins
YP_539690.1	catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A)
YP_539691.1	catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q
YP_539692.1	functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP
YP_539695.1	catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate
YP_539696.1	catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate
YP_539698.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_539706.1	catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate)
YP_539708.1	catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_539711.1	negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer
YP_539713.1	An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group
YP_539716.2	negative modulator of the initiation of chromosome replication
YP_539717.1	catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate
YP_539718.1	catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system
YP_539722.1	response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport
YP_539723.1	sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein
YP_539724.1	One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex
YP_539725.1	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions
YP_539726.1	catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions
YP_539730.1	UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent
YP_539736.1	5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity
YP_539739.1	type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH
YP_539743.1	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol
YP_539744.1	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase
YP_539745.1	SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide
YP_539746.1	component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA
YP_539747.1	catalyzes the interconversion of succinyl-CoA and succinate
YP_539748.1	Catalyzes the only substrate-level phosphorylation in the TCA cycle
YP_539756.1	catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components
YP_539757.1	membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins
YP_539758.1	membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins
YP_539759.1	inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins
YP_539760.1	forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA
YP_539763.1	periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity
YP_539764.1	3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate
YP_539766.1	involved in zinc efflux across the cytoplasmic membrane
YP_539768.1	catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive
YP_539769.1	2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate
YP_539770.1	catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose
YP_539771.1	catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism
YP_539772.1	catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P
YP_539774.2	contains 2 ATP-binding cassettes; involved in the transport of molybdenum
YP_539775.1	represses the modABCD operon and activates the moaABCD and napFDAGHBC operons
YP_539778.1	with ModCB is involved in the high-affinity transport of molybdate
YP_539779.1	part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE
YP_539780.1	Part of the ABC transporter complex modABC involved in molybdenum import
YP_539781.1	YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily
YP_539782.1	catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate
YP_539787.1	outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase
YP_539788.1	YbhB; similar to rat and human kinase inhibitory proteins
YP_539789.1	catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate
YP_539791.1	catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine
YP_539792.1	methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth
YP_539793.1	DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium
YP_539794.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion
YP_539797.1	together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z
YP_539800.1	MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis
YP_539801.2	catalyzes the conversion of molybdopterin precursor Z into molybdopterin
YP_539802.1	catalyzes the conversion of molybdopterin precursor Z into molybdopterin
YP_539815.1	this helicase is not essential cell growth
YP_539819.1	helicase involved in DNA repair and perhaps also replication
YP_539825.1	Fiu; YbiL; porin involved in the uptake of iron complexed with catecholate siderophores (e.g. dihydroxybenzoylserine, dihydroxybenzoate) and beta lactam agents; Fiu interacts with TonB which provides the energy required for transport across the outer membrane; acts as a receptor for iron-siderophores and microcins E492, M, and H47; outer membrane protein
YP_539829.1	similar to ATP-binding component of ABC transporters
YP_539830.1	similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine
YP_539831.1	similar to periplasmic-binding component of ABC transporters
YP_539833.1	binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage
YP_539835.1	OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains
YP_539838.1	Transcriptional regulator that represses the manganese transporter MntH when manganese is present
YP_539845.2	similar to transaldolase from Escherichia coli; many organisms have multiple copies
YP_539846.1	ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase
YP_539847.1	is involved in the formation of active molybdenum cofactor and the chelation of molybdenum
YP_539849.1	with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains
YP_539855.1	catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit
YP_539856.2	BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing
YP_539859.1	penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains
YP_539869.2	functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase
YP_539870.1	YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function
YP_539871.1	NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds
YP_539872.1	responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6
YP_539875.2	part of the PotFGHI ATP-dependent putrescine transporter
YP_539879.1	RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA
YP_539881.1	with ArtPQJI acts to transport arginine across the inner membrane
YP_539882.1	with ArtPMJI transports arginine across the inner membrane
YP_539884.2	With ArtMQJI transports arginine across the inner membrane
YP_539885.1	induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS
YP_539890.1	low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine
YP_539891.1	catalyzes the formation of acetate from pyruvate
YP_539893.1	catalyzes the reduction of hydroxylamine to ammonia and water
YP_539895.1	porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure
YP_539900.2	confers macrolide resistance via active drug efflux
YP_539901.1	with MacA is involved in the export of macrolide
YP_539902.1	inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible
YP_539904.1	involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA
YP_539905.2	ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates
YP_539915.1	stimulates the activities of the other two initiation factors, IF-2 and IF-3
YP_539916.1	leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys
YP_539917.1	in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c
YP_539918.1	in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c
YP_539919.1	catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding
YP_539920.2	mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system
YP_539921.1	DNA-binding membrane protein required for chromosome resolution and partitioning
YP_539922.1	participates with LolB in the incorporation of lipoprotein into the outer membrane
YP_539924.1	catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_539989.2	activates pyruvate formate-lyase 1 under anaerobic conditions
YP_539994.1	catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine
YP_539995.1	catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis
YP_539997.1	Catalyzes the formation of (d)CDP from ATP and (d)CMP
YP_539998.1	in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins
YP_539999.1	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
YP_540001.1	involved in the transport of lipid A across the inner membrane
YP_540002.1	transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate
YP_540005.1	CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS
YP_540009.1	involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA
YP_540010.1	acts with MukB and MukE to condense the chromosome and allow for segregation during cell division
YP_540011.1	acts with MukB and MukF to condense the chromosome and allow for segregation during cell division
YP_540012.1	SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects
YP_540016.1	catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate
YP_540017.1	outer membrane porin F; 1a; Ia; b
YP_540018.1	catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_540019.1	catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate
YP_540021.1	part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease
YP_540022.1	part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding subunit and SsuC the permease
YP_540023.1	catalyzes the release of sulfite from alkanesulfonates
YP_540024.2	part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease
YP_540026.1	catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors
YP_540029.1	catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA
YP_540030.1	Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth
YP_540035.2	catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP
YP_540038.1	OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d
YP_540044.2	catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand
YP_540045.1	catalyzes the formation of methylglyoxal from glycerone phosphate
YP_540051.1	catalyzes the hydrolysis of acylphosphate
YP_540052.1	transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs
YP_540056.1	involved in hydrogen cycling during fermentative growth
YP_540058.1	HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1)
YP_540059.1	involved in processing hydrogenases HyaA and HyaB
YP_540063.1	expressed during stationary phase
YP_540071.1	Member of the two-component regulatory system torS/torR involved in the anaerobic utilization of trimethylamine-N-oxide
YP_540073.1	periplasmic sensory protein associated with the TorRS two-component regulatory system
YP_540074.1	response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes
YP_540077.1	TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor
YP_540078.1	with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA
YP_540079.1	functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock
YP_540082.1	stationary phase that binds TrpR repressor
YP_540092.2	proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein
YP_540099.1	in Yersinia this gene is involved in biofilm formation and hemin adsorption; in Escherichia coli it is involved in PGA biosynthesis and export
YP_540100.1	predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; PgaC; in Yersinia the HmsR protein is an inner membrane protein
YP_540101.1	in Yersinia this protein is involved in biofilm formation and hemin adsorption; related protein PgaB in Escherichia coli is an outer membrane N-deacetylase involved in poly-beta-1,6-N-acetyl-D-glucosamine (PGA) export
YP_540102.1	outer membrane protein essential for the synthesis of poly-beta-1,6-N-acetyl-D-glucosamine (PGA); adhesin required for biofilm formation; PgaA (HmsH) seems to translocate and/or dock PGA to the cell surface; member of the hmsHFRS (ycdSRQP or pgaABCD in Escherichia coli) operon in Yersinia
YP_540133.1	Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space
YP_540172.1	nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex
YP_540173.1	chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex
YP_540174.1	activates the csgBA and csgDEFG operons involved in biofilm formation
YP_540177.1	CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface
YP_540179.1	involved in autoagglutination of curliated cells; not involved in production of curli fibers
YP_540183.1	required for the transfer of succinyl residues to the glucan backbone
YP_540185.1	involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan
YP_540186.1	necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space
YP_540190.1	Confers resistance to fosfomycin and deoxycholate
YP_540191.1	Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA
YP_540197.1	catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids
YP_540198.2	BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing
YP_540200.1	catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis
YP_540202.1	cofactor involved in the reduction of disulfides
YP_540203.2	Confers resistance to norfloxacin and enoxacin
YP_540209.1	regulates the flagellar specific sigma28 transcription factor
YP_540210.1	required for the assembly of the flagellar basal body P-ring
YP_540211.1	with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella
YP_540212.1	with FlgF and B makes up the proximal portion of the flagellar basal body rod
YP_540213.1	acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production
YP_540214.1	the hook connects flagellar basal body to the flagellar filament
YP_540215.1	FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod
YP_540216.1	makes up the distal portion of the flagellar basal body rod
YP_540217.1	part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod
YP_540218.1	part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum
YP_540219.2	Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space
YP_540220.1	with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook
YP_540221.1	with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes
YP_540222.1	bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase
YP_540224.1	catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA
YP_540225.1	Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell
YP_540227.1	some L32 proteins have zinc finger motifs consisting of CXXC while others do not
YP_540228.1	involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY
YP_540229.1	FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs
YP_540231.1	catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_540233.1	carries the fatty acid chain in fatty acid biosynthesis
YP_540234.1	FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP
YP_540235.1	catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate
YP_540238.1	catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP)
YP_540239.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA
YP_540241.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_540247.1	catalyzes the phosphorylation of thiamine to thiamine phosphate
YP_540248.1	hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides
YP_540257.1	part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane
YP_540258.1	outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone
YP_540259.1	part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane
YP_540260.1	catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine
YP_540261.1	Modulates the activities of several enzymes which are inactive in their acetylated form
YP_540264.1	can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate
YP_540265.1	can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component
YP_540266.1	can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component
YP_540267.1	functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase
YP_540269.1	catalyzes the release of the N-terminal amino acid from a tripeptide
YP_540272.1	response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress
YP_540273.1	Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide
YP_540274.1	HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis
YP_540275.1	catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs
YP_540277.2	catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA
YP_540279.1	Converts isocitrate to alpha ketoglutarate
YP_540311.1	DLP12 prophage; Holliday junction resolvase
YP_540372.1	works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell
YP_540373.1	ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums
YP_540374.2	blocks the formation of polar Z-ring septums
YP_540382.1	binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization
YP_540383.1	binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization
YP_540384.1	disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein
YP_540385.1	involved in regulation of intracellular pH under alkaline conditions
YP_540386.1	Multifunctional regulator of fatty acid metabolism
YP_540388.1	catalyzes the oxidative deamination of D-amino acids
YP_540389.1	catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA
YP_540390.1	the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli
YP_540391.1	catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine
YP_540397.1	involved in molybdenum transport
YP_540402.1	periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell
YP_540404.1	phosphotransferaese subunit; phosphorylates dihydroxyacetone along with DhaK/DhaL
YP_540405.1	with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone
YP_540406.1	with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase
YP_540407.1	Positively regulates the dhaKLM operon from a sigma-70 promoter
YP_540410.1	translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1
YP_540411.1	Enables the recycling of peptidyl-tRNAs produced at termination of translation
YP_540412.1	YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function
YP_540413.1	role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport
YP_540414.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP
YP_540415.1	An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis
YP_540416.1	Incorporates lipoproteins in the outer membrane after they are released by the LolA protein
YP_540417.1	catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins
YP_540418.1	recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2
YP_540419.1	HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB
YP_540422.1	catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis
YP_540426.1	in Escherichia coli this protein ly regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions
YP_540430.1	two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase
YP_540439.1	produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine
YP_540443.1	together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose
YP_540447.1	catalyzes the formation of thymidine 5'-phosphate from thymidine
YP_540457.1	highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein
YP_540458.1	catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol)
YP_540461.2	unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity
YP_540462.1	membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins
YP_540464.1	YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase of proteins
YP_540465.1	Involved in cell division; probably involved in intracellular septation
YP_540467.1	receptor for colicin S4
YP_540538.1	catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis
YP_540539.1	catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate
YP_540540.1	monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate
YP_540541.1	bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis
YP_540542.1	with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine
YP_540546.1	catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA
YP_540547.1	catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide
YP_540549.1	SohB; periplasmic protein; member of the peptidase S49 family
YP_540552.1	catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity
YP_540553.1	LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation
YP_540556.1	Catalyzes the conversion of citrate to isocitrate
YP_540557.1	catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate
YP_540561.1	type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase
YP_540562.1	involved in start site selection during the initiation of translation
YP_540567.1	c-di-GMP phosphodiesterase; probably degrades signalling molecule c-di-GMP
YP_540568.1	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
YP_540570.1	Catalyzes a key regulatory step in fatty acid biosynthesis
YP_540582.2	transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor
YP_540583.1	involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF
YP_540584.1	acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding
YP_540585.1	with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock
YP_540587.1	rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide
YP_540603.1	regulates genes involved in the biosynthesis and transport of aromatic amino acids
YP_540604.1	antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein
YP_540613.1	with UspC and UspD is involved in resistance to UV irradiation
YP_540614.2	Global transcription factor that controls the expression of over 100 target genes in response to anoxia
YP_540623.1	exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA
YP_540624.1	TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs
YP_540643.1	FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds
YP_540644.2	involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain
YP_540646.1	NAD-linked
YP_540648.2	B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm
YP_540654.1	involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans
YP_540656.1	acetylation of N-terminal serine of 30S ribosomal subunit protein L7
YP_540659.1	with TehA confers resistance to tellurite
YP_540672.1	catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation
YP_540701.1	nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase
YP_540705.1	similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs
YP_540706.1	malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate
YP_540707.1	protein D; stationary-phase-induced ribosome-associated; in Escherichia coli this protein becomes associated with the ribosome; expression increases during stationary phase
YP_540711.1	heme-regulated phosphodiesterase with phosphodiesterase activity with cAMP but not with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate
YP_540722.1	regulates the cellular response to acid resistance
YP_540724.1	in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase
YP_540725.1	synonym: ydeQ
YP_540747.1	catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate
YP_540749.1	catalyzes the formation of D-tagaturonate from D-altronate
YP_540752.1	catalyzes the formation of glutamate from glutamine
YP_540753.1	in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase
YP_540757.1	protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function
YP_540758.1	Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes
YP_540759.2	transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF
YP_540761.1	converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism
YP_540768.1	YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters
YP_540771.1	NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine
YP_540785.1	DmsB-like; dimethyl sulfoxide reductase-like subunit
YP_540787.2	binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane
YP_540789.1	DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium
YP_540793.1	required for growth and survival under moderately acid conditions
YP_540796.1	with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS
YP_540797.1	with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS
YP_540798.1	transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes
YP_540799.1	catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme
YP_540800.1	forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm
YP_540805.1	response regulator in two-component regulatory system with RstB
YP_540807.1	binds to DNA replication terminator sequences to prevent passage of replication forks
YP_540808.1	class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle
YP_540816.1	Acts on the hydroxyl group at position 7 of the steroid frame
YP_540817.1	regulates malXY which are involved in maltose-glucose transport
YP_540818.1	phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site
YP_540820.1	catalyzes the formation of inosine from adenosine
YP_540824.1	YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes
YP_540827.1	part of membrane-bound complex thought to be involved in electron transport to nitrogen
YP_540828.1	part of membrane-bound complex thought to be involved in electron transport to nitrogen
YP_540829.1	RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents
YP_540830.1	part of membrane-bound complex hought to be involved in electron transport to nitrogen
YP_540831.1	in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase
YP_540832.1	DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines
YP_540834.1	mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation
YP_540836.1	catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal
YP_540837.1	catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr)
YP_540838.1	catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate
YP_540839.1	MliC; membrane-bound lysozyme inhibitor of c-type lysozyme
YP_540840.1	catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling
YP_540842.1	Transcription regulator that can both activate or repress expression
YP_540846.1	SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water
YP_540850.1	FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide
YP_540851.1	Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione
YP_540852.1	Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A)
YP_540856.1	SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals
YP_540858.1	binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers
YP_540860.1	uncharacterized member of the major facilitator superfamily (MFS)
YP_540861.1	catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge
YP_540862.1	catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine
YP_540863.1	NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones
YP_540875.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_540878.1	Acts with SufS to catalyze the formation of L-alanine from L-cysteine
YP_540879.1	catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine
YP_540880.1	with SufBC activates cysteine desulfurase SufS
YP_540881.1	part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE
YP_540882.1	with SufCD activates cysteine desulfurase SufS
YP_540883.1	functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein
YP_540887.1	YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function
YP_540891.1	YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate
YP_540892.1	catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis
YP_540894.2	may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain
YP_540897.2	YdiO, YdiQ, YdiR, YdiS, and YdiT may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain
YP_540898.1	May play a role in a redox process
YP_540901.1	acts in anaerobic beta-oxidation of fatty acids; possible ligase/synthase involved in anaerobic growth on fatty acids
YP_540902.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_540904.1	tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate
YP_540909.1	ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell
YP_540910.1	similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane
YP_540911.1	with BtuD and BtuF transports vitamin B12 into the cell
YP_540912.1	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
YP_540913.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily
YP_540914.2	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily
YP_540916.1	binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit
YP_540918.1	IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits
YP_540919.1	catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_540928.1	YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate
YP_540932.1	Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide
YP_540935.1	represses the celABCDF-ydjC operon involved in carbon uptake
YP_540936.1	catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake
YP_540937.1	catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake
YP_540938.1	catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake
YP_540940.1	osmotically-inducible lipoprotein E; activator of ntr-like gene protein
YP_540941.1	catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers
YP_540942.1	3' incision activity; acts with UvrC
YP_540945.1	periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP
YP_540946.1	catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism
YP_540947.1	catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation
YP_540948.1	a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH
YP_540950.1	catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate
YP_540952.2	removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction
YP_540964.1	converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer
YP_540965.1	decatenates replicating daughter chromosomes
YP_540966.1	catalyzes the formation of selenophosphate from selenide and ATP
YP_540969.1	SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane
YP_540970.1	converts asparagine to aspartate and ammonia
YP_540971.2	catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide
YP_540981.1	this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress
YP_541006.1	Activates fatty acids by binding to coenzyme A
YP_541024.1	hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel
YP_541026.1	membrane protein YebN
YP_541027.1	methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth
YP_541033.1	synonym: yobG , b1826
YP_541037.1	metalloprotease
YP_541038.1	Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3
YP_541039.1	affects solute and DNA transport through an unknown mechanism
YP_541043.1	in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA
YP_541046.1	Plays a key role in signaling protein misfolding via the cpxR/cpxA transducing system; modulates the phosphorylated status of many phosphoproteins
YP_541053.1	3'-5' exonuclease activity on single or double-strand DNA
YP_541054.1	PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues
YP_541057.1	secreted protein; unknown function
YP_541059.1	non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis
YP_541060.1	catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate
YP_541061.1	catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate
YP_541062.1	catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate
YP_541064.1	Represses the expression of the zwf, eda, glp and gap
YP_541065.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_541066.1	Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA
YP_541068.1	involved in transport of zinc(II) with ZnuA and C
YP_541069.1	involved in transport of zinc(II) with ZnuA and C
YP_541070.1	involved in transport of zinc(II) with ZnuA and C
YP_541071.1	promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration
YP_541072.1	plays an essential role in ATP-dependent branch migration of the Holliday junction
YP_541074.1	endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity
YP_541076.1	converts dATP to dAMP and pyrophosphate
YP_541077.1	catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes
YP_541087.1	catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase
YP_541089.2	membrane protein involved in the flagellar export apparatus
YP_541090.1	membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export
YP_541092.2	cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation
YP_541093.1	chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble
YP_541094.1	regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins
YP_541095.1	methylates the MCP
YP_541098.1	chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component
YP_541099.1	with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine
YP_541100.1	With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine
YP_541101.1	With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems
YP_541102.1	with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems
YP_541103.1	ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress
YP_541105.1	biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature
YP_541106.1	Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose
YP_541107.2	Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose
YP_541113.1	cytoplasmic iron storage protein
YP_541118.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
YP_541119.1	in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system
YP_541121.2	regulates genes involved in cell division
YP_541124.1	catalyzes the formation of pyruvate from D-cysteine
YP_541126.1	expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence
YP_541127.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes
YP_541128.1	structural flagella protein; individual Salmonella serotypes usually alternate between the production of 2 antigenic forms of flagella, termed phase 1 and phase 2, each specified by separate structural genes
YP_541129.1	involved in flagellin assembly
YP_541130.1	flagellin specific chaperone
YP_541131.1	binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family
YP_541132.1	converts 1,4-alpha-D-glucans to maltodextrin
YP_541139.1	DLP12 prophage; similar to PEBP/RK1P protein family in eukaryotes that inhibits MEK phosphorylation by Raf-1; crystal structure suggests similar properties but exact function is unknown
YP_541140.1	member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation
YP_541141.2	forms a junction between the M-ring and FlgB during flagella biosynthesis
YP_541142.1	the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod
YP_541143.1	One of three proteins involved in switching the direction of the flagellar rotation
YP_541144.1	binds to and inhibits the function of flagella specific ATPase FliI
YP_541145.1	involved in type III protein export during flagellum assembly
YP_541146.1	rod/hook and filament chaperone
YP_541148.1	interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring
YP_541149.1	with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation
YP_541150.1	One of three proteins involved in switching the direction of the flagellar rotation
YP_541151.1	with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus
YP_541152.1	FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus
YP_541153.1	with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus
YP_541154.1	FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus
YP_541156.1	transcription is regulated by RpoS and DsrA RNA
YP_541160.1	catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate
YP_541170.1	Hsp31 stabilizes early unfolding protein intermediates under severe heat stress
YP_541172.2	induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced
YP_541174.1	in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ
YP_541175.1	in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme
YP_541180.1	catalyzes the conversion of chorismate to salicylate in the biosynthesis of the siderophore yersiniabactin
YP_541189.1	salicyl-AMP ligase
YP_541197.2	Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile
YP_541201.1	LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB
YP_541202.2	Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation
YP_541227.1	similar to universal stress protein
YP_541228.1	catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole
YP_541229.1	catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole
YP_541230.1	catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP
YP_541284.2	Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates
YP_541290.2	Antitoxin that counteracts the effect of the YoeB toxin
YP_541291.1	long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors
YP_541292.1	catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer
YP_541293.1	catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis
YP_541294.1	catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate
YP_541295.1	with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide
YP_541296.1	catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide
YP_541297.1	catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase
YP_541298.1	catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis
YP_541301.1	catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate
YP_541310.1	with dTDP-4-dehydrorhamnose 3,5-epimerase forms a complex known as dTDP-L-rhamnose synthetase; catalyzes the reduction of dTDP-4-dehydro-6-deoxy-L-mannose to dTDP-L-rhamnose
YP_541311.1	NAD(P) binding; catalyzes the formation of dTDP-4-dehydro-6-deoxy-D-glucose from dTDP-glucose
YP_541313.1	together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose
YP_541314.1	WcaM from Salmonella enterica is essential for biofilm formation on HEp-2 cells and chicken intestinal tissue but not on a plastic surface; may be involved in the biosynthesis of colanic acid
YP_541319.1	WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid
YP_541327.1	acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit)
YP_541329.1	essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance
YP_541331.1	acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium
YP_541333.2	Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide)
YP_541334.1	Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis
YP_541339.1	YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs
YP_541340.1	Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis
YP_541341.1	functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor
YP_541342.1	contains a MASE1 (Membrane-Associated Sensor) domain; potentially involved in signal transduction
YP_541343.1	inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine
YP_541348.2	Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate
YP_541349.1	Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate
YP_541350.1	Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate
YP_541353.1	response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport
YP_541361.1	cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role
YP_541363.1	Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate
YP_541365.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_541366.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_541368.2	catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway
YP_541370.2	catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate
YP_541376.1	catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine
YP_541377.1	catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP
YP_541379.1	membrane protein conferring nickel and cobalt resistance
YP_541387.1	methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content
YP_541396.1	unknown function; when overproduced it confers drug-resistance
YP_541406.2	component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent
YP_541407.1	specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7
YP_541411.2	may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride
YP_541415.1	Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis
YP_541418.1	function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain
YP_541419.1	catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines
YP_541420.1	ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex
YP_541421.1	with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains
YP_541423.1	negative regulator of the mglBAC operon for galactose utilization
YP_541426.1	involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer
YP_541428.1	Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein
YP_541433.1	Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues
YP_541435.1	Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively
YP_541436.1	activator of nucleoside metabolism
YP_541441.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_541442.1	converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers
YP_541443.1	phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr
YP_541447.1	Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein
YP_541451.1	by similarity, Spr seems to have peptidase activity; involved in thermoresistance
YP_541458.1	Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance
YP_541459.2	catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA
YP_541461.2	the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response
YP_541469.1	nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes
YP_541473.1	CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane
YP_541477.1	ATP-binding protein; required for proper cytochrome c maturation
YP_541478.1	with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone
YP_541479.2	small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA
YP_541480.1	part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA
YP_541481.1	part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway
YP_541482.1	periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC
YP_541484.1	Predicted role in electron transfer to the periplasmic nitrate reductase NapA.
YP_541487.1	serine protease inhibitor, inhibits trypsin and other proteases
YP_541488.1	malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate
YP_541489.1	efflux pump for the antibacterial peptide microcin J25
YP_541493.1	catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway
YP_541495.1	allows for ions and hydrophilic solutes to cross the outer membrane
YP_541497.1	two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF
YP_541499.1	with AtoC is a member of a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism
YP_541500.1	with AtoS is a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism
YP_541510.1	negatively supercoils closed circular double-stranded DNA
YP_541511.1	Involved in ubiquinone biosynthesis
YP_541513.1	Catalyzes the rate-limiting step in dNTP synthesis
YP_541514.1	B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA
YP_541515.1	plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases
YP_541517.1	hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic
YP_541518.1	catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell
YP_541519.1	anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor
YP_541520.1	sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters
YP_541521.2	anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate
YP_541533.2	catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose
YP_541534.1	catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate
YP_541535.1	Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains
YP_541537.1	catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A
YP_541542.1	catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate
YP_541543.1	catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA
YP_541545.1	catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA
YP_541546.1	SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis
YP_541550.1	member of metallo-beta-lactamase; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions
YP_541554.1	Catalyzes the transfer of electrons from NADH to quinone
YP_541555.1	Catalyzes the transfer of electrons from NADH to quinone
YP_541556.1	Catalyzes the transfer of electrons from NADH to ubiquinone
YP_541557.1	Catalyzes the transfer of electrons from NADH to quinone
YP_541558.1	Catalyzes the transfer of electrons from NADH to quinone
YP_541559.1	Catalyzes the transfer of electrons from NADH to quinone
YP_541560.1	Catalyzes the transfer of electrons from NADH to quinone
YP_541561.1	Catalyzes the transfer of electrons from NADH to quinone
YP_541562.1	shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase
YP_541563.1	Catalyzes the transfer of electrons from NADH to quinone
YP_541564.1	NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms
YP_541565.1	The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen
YP_541566.1	Catalyzes the transfer of electrons from NADH to quinone
YP_541570.1	broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor
YP_541577.1	AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA
YP_541579.1	catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate
YP_541585.1	catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate
YP_541593.1	catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate
YP_541594.1	Catalyzes first step of the de novo purine nucleotide biosynthetic pathway
YP_541595.1	membrane protein required for colicin V production
YP_541599.2	catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits
YP_541601.1	mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability
YP_541604.1	in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein
YP_541606.1	FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP
YP_541607.2	catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules
YP_541611.1	D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm
YP_541612.1	catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis
YP_541613.1	involved in methylation of ribosomal protein L3
YP_541623.1	multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate
YP_541624.1	FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth
YP_541627.1	sensitivity to phage T2
YP_541640.1	bacteriophage HK620 gene 16-like
YP_541641.1	bacteriophage HK620 gene 20-like
YP_541642.1	bacteriophage HK620 gene 7-like
YP_541643.1	bacteriophage HK620 gene 14-like
YP_541644.1	bacteriophage HK620 gene 26-like
YP_541645.1	bacteriophage HK620 gene 10-like
YP_541649.1	bacteriophage HK620 gene 8-like
YP_541650.1	bacteriophage HK620 gene 1-like
YP_541651.1	bacteriophage HK620 gene 2-like
YP_541657.1	bacteriophage HK620 gene R-like
YP_541658.1	bacteriophage HK620 gene S-like
YP_541692.1	regulates the synthesis and expression of the dsdXA operon and dadA gene
YP_541693.1	member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function
YP_541694.1	catalyzes the formation of pyruvate from serine
YP_541698.1	response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance
YP_541701.1	member of the AEC family of auxin efflux transporters; unknown function
YP_541702.1	catalyzes the formation of formyl-CoA from oxalyl-CoA
YP_541703.1	catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA
YP_541707.1	Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock
YP_541713.1	metalloprotein
YP_541714.1	Xaa-Pro aminopeptidase; limited methionine aminopeptidase
YP_541717.1	catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate
YP_541726.1	Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation
YP_541730.1	catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation
YP_541734.1	this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB
YP_541735.1	interacts with cell division protein FitsZ and may be required to anchor septal ring structure
YP_541737.1	role in sulfur assimilation
YP_541738.1	CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis
YP_541741.1	Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system
YP_541742.1	functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose
YP_541743.1	catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal
YP_541745.1	catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide
YP_541747.1	Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import
YP_541751.1	catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway
YP_541752.1	belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component
YP_541760.1	catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis
YP_541761.1	activates the transcription of the ethanolamine utilization operon
YP_541762.1	synonym: b2438, yffI
YP_541763.1	synonym: yffJ, b2439
YP_541764.1	catalyzes the formation of acetaldehyde from ethanolamine
YP_541766.1	ethanolamine utilization protein EutA
YP_541767.1	synonym: yffU, b2452
YP_541768.1	synonym: yffV, b2453
YP_541769.1	synonym: yffW, b2454
YP_541770.1	synonym: yffX, b2455
YP_541771.1	synonym: yffY, b2456, cchB
YP_541772.1	synonym: yffZ, b2457, cchA
YP_541773.1	in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta
YP_541778.1	NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate
YP_541779.1	synonym: b2464, G7294, alaT
YP_541780.2	catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase
YP_541785.1	unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic)
YP_541787.1	synonym: b2470, yffA
YP_541789.1	dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.
YP_541791.2	Displays esterase activity toward palmitoyl-CoA and pNP-butyrate
YP_541794.1	catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase
YP_541796.1	catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis
YP_541797.2	negative transcriptional regulator of the gcvTHP operon
YP_541798.1	bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine
YP_541803.1	controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP
YP_541805.1	Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate
YP_541806.1	catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis
YP_541807.1	glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate
YP_541808.1	catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate
YP_541816.1	contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway
YP_541817.1	catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate
YP_541818.1	bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides
YP_541823.2	EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains
YP_541824.1	with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis
YP_541826.1	catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG
YP_541827.1	catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis
YP_541829.1	23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance
YP_541831.1	catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate
YP_541832.1	penicillin-insensitive transglycosylase/transpeptidase
YP_541834.2	catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds
YP_541835.2	enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I
YP_541836.1	catalyzes the removal of an N-terminal amino acid from a peptide or arylamide
YP_541839.2	involved in the maturation of iron-sulfur cluster-containing proteins
YP_541840.1	J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins
YP_541841.1	forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein
YP_541842.1	synonym: yfhN, nifU, b2529
YP_541843.1	catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis
YP_541844.1	regulates the expression of the iscRSUA operon
YP_541849.1	transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters
YP_541861.1	catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate
YP_541862.1	flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine
YP_541863.1	indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA
YP_541868.1	catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis
YP_541869.1	YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function
YP_541875.1	Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids
YP_541876.1	involved in the de novo synthesis of pyridoxine (Vitamin B6)
YP_541877.1	involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA
YP_541878.1	Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome
YP_541879.1	cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity
YP_541881.1	catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins
YP_541882.1	binds to the ribosome on the universally-conserved alpha-sarcin loop
YP_541883.1	involved in the reduction of the SoxR iron-sulfur cluster
YP_541884.1	periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP
YP_541886.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response
YP_541887.1	catalyzes the formation of oxaloacetate from L-aspartate
YP_541889.1	facilitates an early step in the assembly of the 50S subunit of the ribosome
YP_541892.2	stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit
YP_541893.1	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
YP_541899.1	catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome
YP_541904.1	IS621-Tnp
YP_541914.1	responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA
YP_541915.1	with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline
YP_541918.1	associated with 30S ribosomal subunit; interferes with translation elongation
YP_541919.1	bifunctional P protein; catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis
YP_541920.1	bifunctional T protein; catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis
YP_541921.1	catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive
YP_541926.1	this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
YP_541927.1	methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA
YP_541928.1	Essential for efficient processing of 16S rRNA
YP_541929.2	binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity
YP_541930.1	with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins
YP_541934.1	with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor
YP_541936.1	catalyzes the phosphorylation of NAD to NADP
YP_541941.1	binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation
YP_542001.1	in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution
YP_542002.1	catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate
YP_542003.1	catalyzes the formation of succinate from succinate semialdehyde; NADP dependent
YP_542004.1	catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate
YP_542006.2	regulator of gab gene expression
YP_542021.1	in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF
YP_542022.1	Catalyzes the rate-limiting step in dNTP synthesis
YP_542023.1	B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE
YP_542024.1	with ProWX is involved in the high-affinity uptake of glycine betaine
YP_542025.1	with ProVX is involved in the high-affinity uptake of glycine betaine
YP_542026.2	with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine
YP_542031.1	DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB
YP_542036.1	catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2
YP_542037.1	involved in the first step of glutathione biosynthesis
YP_542039.1	YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent
YP_542040.1	affects carbohydrate metabolism; has regulatory role in many processes
YP_542041.1	Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_542043.1	binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities
YP_542044.1	catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs
YP_542046.1	membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan
YP_542049.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_542050.1	catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate
YP_542051.1	regulator for glucitol utilization
YP_542052.1	regulates genes involved in glucitol utilization
YP_542053.1	catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate
YP_542054.1	Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon
YP_542055.1	detoxifies nitric oxide using NADH
YP_542056.1	catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase
YP_542058.1	involved in electron transport from formate to hydrogen
YP_542060.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_542063.1	involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE
YP_542066.1	electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate
YP_542069.1	catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3)
YP_542071.1	regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon
YP_542072.1	plays a role in hydrogenase nickel cofactor insertion
YP_542073.1	GTP hydrolase involved in nickel liganding into hydrogenases
YP_542074.1	HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase
YP_542081.1	This protein performs the mismatch recognition step during the DNA repair process
YP_542089.1	member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function
YP_542094.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses
YP_542095.1	outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus
YP_542097.1	catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins
YP_542098.1	catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate
YP_542099.1	catalyzes the modification of U13 in tRNA(Glu)
YP_542100.1	catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate
YP_542101.1	4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers
YP_542102.1	forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein
YP_542104.1	converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis
YP_542105.1	may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ
YP_542106.1	with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP
YP_542107.1	catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3
YP_542109.1	catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite
YP_542110.1	hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide
YP_542111.1	catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity
YP_542131.1	enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis
YP_542132.1	CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer
YP_542133.1	functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase Era
YP_542134.1	MazF; endoribonuclease; toxin of the ChpA-ChpR toxin-antitoxin system
YP_542136.1	part of the MazF-MazE toxin-antitoxin system; conteracts MazF
YP_542137.1	(p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP
YP_542138.1	in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]
YP_542139.1	part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system
YP_542140.1	synonym: gdh1, b2787, ygcX, EG13167
YP_542143.1	An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group
YP_542144.1	catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp
YP_542146.1	SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function
YP_542147.1	catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis
YP_542152.1	has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups
YP_542154.1	catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate
YP_542157.1	catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose
YP_542160.1	regulates expression of genes involved in L-fucose utilization
YP_542163.1	Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence
YP_542169.2	membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues
YP_542199.2	catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis
YP_542200.1	helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity
YP_542201.1	helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity
YP_542202.1	synonym: b2821, ptr
YP_542203.1	catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination
YP_542209.1	ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived
YP_542210.1	transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein
YP_542211.1	member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr
YP_542212.1	hydrolyzes diadenosine polyphosphate
YP_542214.1	MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair
YP_542218.1	complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH
YP_542220.1	AAS bifunctional protein; Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1
YP_542221.1	controls transcription of galETKM
YP_542222.1	catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding
YP_542223.1	activates the transcription of the lysA gene encoding diaminopimelate decarboxylase
YP_542225.1	catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate
YP_542226.1	4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
YP_542227.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis
YP_542230.1	molybdenum cofactor-binding protein; participates in purine salvage
YP_542231.1	FAD-binding subunit; with XdhA and XdhC participates in purine salvage
YP_542232.1	iron-sulfur-binding subunit; with XdhA and XdhB participates in purine salvage
YP_542235.1	catalyzes the formation of pyruvate from 2,3-diaminopropionate
YP_542236.1	Zn-dependent extracellular dipeptidase; similar to succinyl-diaminopimelate desuccinylases
YP_542237.1	catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position
YP_542238.1	catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP
YP_542242.1	with YgfM and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfK mutants are unable to reduce selenate; involved in purine salvage process; seems to act as an oxidoreductase, but sequence similarity suggests it is a dihydrothymine dehydrogenase
YP_542243.1	in Escherichia coli expression is induced in response to phase-specific signals and controlled by RpoS
YP_542244.1	with YgfK and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfM contains a FAD domain
YP_542245.1	with YgfK and YgfM forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; molybdopterin-containing enzyme; oxidase activity toward hypoxanthine and xanthine can be detected if these substrates are present at high concentration
YP_542247.1	Catalyzes the deamination of guanine
YP_542250.1	unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic)
YP_542253.1	catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate
YP_542254.1	class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1
YP_542256.1	5'-3' single-stranded-DNA-specific exonuclease
YP_542257.1	DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity
YP_542258.1	site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs
YP_542259.1	An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic
YP_542263.1	physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator
YP_542267.1	acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine
YP_542268.1	part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor
YP_542269.1	catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein
YP_542272.1	Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone
YP_542273.1	exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide
YP_542274.1	the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown
YP_542277.1	ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function
YP_542278.1	catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate
YP_542279.1	Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway
YP_542281.2	specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport
YP_542285.1	Involved in the export of arginine
YP_542286.1	participates in the regulation of osmotic pressure changes within the cel
YP_542287.1	catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate
YP_542288.1	Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway
YP_542289.1	NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate
YP_542300.1	TolM; with CmtA (IIBC), CmtB possibly forms the mannitol-like permease component of the cryptic mannitol phosphotransferase system, which phosphorylates and transports various carbohydrates and polyhydric alcohols in Escherichia coli; cytoplasmic protein
YP_542302.2	catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase
YP_542304.1	catalyzes the formation of putrescine from agmatine
YP_542306.1	catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis
YP_542310.2	catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase
YP_542314.2	in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase
YP_542315.1	catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione
YP_542317.1	similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function
YP_542322.1	HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine
YP_542323.1	catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III
YP_542325.1	catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis
YP_542329.1	tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine
YP_542333.1	Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues
YP_542343.1	CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS
YP_542355.2	similar to general secretory pathway protein L
YP_542364.1	part of the general (type II) secretion pathway (GSP), a signal sequence-dependent process responsible for protein export; involved in trans-location of exoproteins from the cytoplasm to the periplasm
YP_542370.1	catalyzes the formation of malate from glyoxylate and acetyl-CoA
YP_542375.1	activates fatty acids by binding to coenzyme A
YP_542388.1	catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction
YP_542389.1	YghU; B2989; one of eight  glutathione transferases from E. coli
YP_542391.1	plays a role in hydrogenase nickel cofactor insertion
YP_542393.1	protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC)
YP_542394.1	involved in hydrogen uptake
YP_542395.1	HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits
YP_542396.1	Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2
YP_542397.1	involved in hydrogen uptake
YP_542403.1	membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell
YP_542404.1	membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell
YP_542406.1	catalyzes the formation of L-homocysteine from cystathionine
YP_542410.1	methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate
YP_542424.1	decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling
YP_542425.1	YgiS; uncharacterized periplasmic protein that seems to be part of a binding-protein-dependent transport system
YP_542428.1	response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes
YP_542429.1	synonym: b3026, ygiO, G7576, ygiY
YP_542442.1	decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling
YP_542443.1	Displays esterase activity toward palmitoyl-CoA and pNP-butyrate
YP_542446.1	ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose
YP_542447.1	trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell
YP_542454.1	seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine
YP_542455.1	synonym: ygiE, b3040
YP_542461.1	DHBP synthase; functions during riboflavin biosynthesis
YP_542463.1	Involved in glycogen synthesis. May be involved in glycogen priming
YP_542466.1	catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose
YP_542467.2	catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme
YP_542470.1	catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases
YP_542471.1	BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell
YP_542472.1	catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin
YP_542473.1	involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX
YP_542474.1	activates expression of genes required for L-tartrate-dependent anaerobic growth on glycerol
YP_542475.1	Involved in the tartrate degradation pathway
YP_542476.1	Involved in the tartrate degradation pathway
YP_542478.1	in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity
YP_542480.1	a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA
YP_542481.1	synthesizes RNA primers at the replication forks
YP_542483.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria
YP_542488.2	catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate
YP_542493.1	in Escherichia coli this is the second beta-galactosidase system
YP_542494.1	in Escherichia coli this is the second beta-galactosidase system
YP_542504.1	involved in the import of serine and threonine coupled with the import of sodium
YP_542507.1	catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism
YP_542509.2	regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization.
YP_542527.1	catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism
YP_542528.1	involved in the import of threonine and serine in combination with the import of a proton
YP_542529.1	catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic
YP_542530.1	regulates the tdcABCDEFG operon which is involved in amino acid degradation
YP_542531.2	participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon
YP_542533.2	catalyzes the reduction of tartronate semialdehyde to glycerate
YP_542534.1	cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate
YP_542536.1	synonym: b3128, yhaG
YP_542537.1	transcriptional repressor for the agaZVWA and agaSYBCDI operons
YP_542539.1	catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake;involved in N-acetylgalactosamine transport
YP_542545.1	catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway
YP_542546.1	catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport
YP_542547.1	catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane;protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport
YP_542548.1	catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport
YP_542553.1	Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein
YP_542565.1	tryptophan transporter of high affinity
YP_542567.2	participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division
YP_542569.1	lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing
YP_542572.1	primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence
YP_542573.1	catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs
YP_542574.2	associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock
YP_542575.1	Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
YP_542577.1	modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination
YP_542578.1	in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins
YP_542580.1	catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis
YP_542583.1	catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YP_542584.2	catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate
YP_542585.1	inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins
YP_542586.1	Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit
YP_542588.1	RNA binding protein found associated to pre-50S subunit of the ribosome; role in ribosome assembly; necessary for optimal growth but not cell viability
YP_542589.1	necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YP_542590.1	penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains
YP_542591.1	essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication
YP_542593.1	involved in the peptidyltransferase reaction during translation
YP_542597.1	activator of maltose metabolism genes
YP_542598.1	adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active
YP_542606.1	ATP-binding subunit of a  ABC toluene efflux transporter
YP_542607.1	YrbG; inner membrane protein involved in cell envelope integrity; sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers
YP_542609.1	forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis
YP_542611.1	LptA; periplasmic binding protein part of a  ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system
YP_542613.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen
YP_542614.1	YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing
YP_542619.1	glycosyltransferase; polymerizes glycan strands in the peptidoglycan
YP_542621.1	sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA
YP_542624.2	catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate
YP_542625.1	glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate
YP_542627.1	catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein
YP_542628.1	Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate
YP_542630.1	catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid
YP_542631.1	Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization
YP_542633.1	transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation
YP_542635.1	forms a direct contact with the tRNA during translation
YP_542636.2	in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit
YP_542640.1	synonym: b3234, hhoA, EG12612
YP_542641.1	synonym: b3235, hhoB, htrH
YP_542642.1	oxidizes malate to oxaloacetate
YP_542643.1	regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes
YP_542646.1	with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate
YP_542647.1	with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate
YP_542648.2	membrane protein AaeX; the gene is a member of the aaeXAB operon
YP_542650.1	responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA
YP_542652.2	involved in the processing of the 5'end of 16S rRNA
YP_542653.1	Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell
YP_542654.1	part of cell wall structural complex MreBCD; transmembrane component
YP_542655.1	in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall
YP_542656.1	functions in MreBCD complex in some organisms
YP_542658.1	regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules
YP_542662.1	orf 5' of BCCP
YP_542663.1	composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism
YP_542664.2	an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
YP_542667.1	synonym: b3750, rbsA, rbsP, rbsT
YP_542668.1	synonym: rbsT, rbsP, b3749, prlB
YP_542670.1	catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway
YP_542675.1	mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase
YP_542676.1	methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype
YP_542678.1	Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription
YP_542694.1	AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate
YP_542695.1	RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA
YP_542699.1	cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+)
YP_542700.1	modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth
YP_542701.1	catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase
YP_542702.1	involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain
YP_542703.1	forms homopentamer; channel that opens in response to pressure or hypoosmotic shock
YP_542705.1	mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators
YP_542707.1	is a component of the macrolide binding site in the peptidyl transferase center
YP_542708.1	catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme
YP_542709.1	primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination
YP_542710.1	located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3
YP_542712.1	located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA
YP_542713.1	smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif
YP_542714.1	forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase
YP_542715.1	late assembly protein
YP_542716.1	L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7
YP_542718.1	located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance
YP_542719.1	binds 5S rRNA along with protein L5 and L25
YP_542721.1	ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance
YP_542723.1	binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
YP_542724.1	located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif
YP_542725.1	part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13
YP_542726.1	assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel
YP_542728.1	binds to the 23S rRNA between the centers for peptidyl transferase and GTPase
YP_542729.1	primary binding protein; helps mediate assembly; involved in translation fidelity
YP_542730.1	one of the stabilizing components for the large ribosomal subunit
YP_542732.1	located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e
YP_542733.1	forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation
YP_542735.1	binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center
YP_542736.1	protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
YP_542738.1	one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation
YP_542739.1	binds third domain of 23S rRNA and protein L29; part of exit tunnel
YP_542741.1	L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA
YP_542743.1	binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin
YP_542744.1	NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex
YP_542745.1	calcium-binding protein that may be required for the initiation of chromosome replication
YP_542746.1	synonym: b3323, yheD, EG12888
YP_542747.1	synonym: b3324, yheE, EG12889
YP_542748.1	synonym: b3325, yheF, EG12890
YP_542749.1	synonym: b3326, yheG, EG12891
YP_542750.1	synonym: b3327, hofF, hopF, EG12885
YP_542751.1	synonym: b3328, hofG, hopG, hopg, EG12886
YP_542752.1	synonym: b3329, hofH, hopH, EG12887
YP_542753.1	synonym: b3330, yheH, yheh, EG12892
YP_542754.1	synonym: b3331, yheI, yhei, EG12893
YP_542755.1	synonym: b3332, yheJ, yhej, EG12894
YP_542756.1	synonym: b3333, yheK, yheL, yhek, EG12895
YP_542757.1	synonym: b3334, hopZ, pshM
YP_542758.1	synonym: b3335, hofD, hopD, hopO, yheC
YP_542759.1	iron storage protein
YP_542760.1	synonym: b3337, yheA, gen-64
YP_542763.1	EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu
YP_542766.1	catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis
YP_542767.1	BirA bifunctional protein; catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon
YP_542768.1	catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis
YP_542774.1	involved in de novo purine biosynthesis
YP_542775.1	catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis
YP_542776.1	synonym: b4003, hydH
YP_542777.2	synonym: b4002, yjaI, zra
YP_542779.1	histone-like DNA-binding protein
YP_542781.1	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures
YP_542782.1	catalyzes the formation of coproporphyrinogen from uroporphyrinogen III
YP_542783.1	can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates
YP_542784.1	binds specifically to the major sigma factor sigma 70; active in stationary phase
YP_542785.1	required for the synthesis of the hydromethylpyrimidine moiety of thiamine
YP_542786.1	catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate
YP_542788.1	with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate
YP_542789.2	functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate
YP_542790.1	in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center
YP_542791.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter
YP_542792.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme
YP_542794.1	present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors
YP_542795.1	binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit
YP_542796.1	in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA
YP_542798.1	binds directly to 23S ribosomal RNA
YP_542799.1	Modulates Rho-dependent transcription termination
YP_542800.1	forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force
YP_542801.2	EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu
YP_542802.1	EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene
YP_542803.1	binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit
YP_542804.2	interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance
YP_542805.1	in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs
YP_542806.1	in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs
YP_542807.1	in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs
YP_542809.1	rotamase
YP_542811.1	rotamase
YP_542813.1	involved in potassium efflux
YP_542814.1	required for KefB activity
YP_542818.1	synonym: b3355, yhfF
YP_542820.1	complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons
YP_542822.1	DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate
YP_542823.1	aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity
YP_542830.1	involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations
YP_542831.1	member of the FNT family of formate and nitrite transporters
YP_542832.1	multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin
YP_542837.1	phosphotriesterase homology protein; PhP; YhfV; member of a family of proteins related to phosphotriesterase (PTE)
YP_542842.1	catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_542843.1	catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate
YP_542844.1	catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate
YP_542847.1	catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis
YP_542848.1	type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis
YP_542849.1	outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa
YP_542854.1	bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits
YP_542855.1	ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose
YP_542858.1	synonym: b3400, hsp15, yrfH, EG12929
YP_542859.1	becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers
YP_542863.1	PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP
YP_542864.1	membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR
YP_542865.1	part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation
YP_542867.1	necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YP_542870.1	cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake
YP_542873.1	Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis
YP_542874.2	involved in high-affinity gluconate transport
YP_542875.1	cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source
YP_542877.1	amylomaltase; acts to release glucose from maltodextrins
YP_542879.1	Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides
YP_542880.1	catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester
YP_542883.1	represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism
YP_542884.1	protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity
YP_542885.1	belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine
YP_542886.2	in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane
YP_542898.1	catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose
YP_542899.2	catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate
YP_542900.1	catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen
YP_542901.1	catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain
YP_542902.1	catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde
YP_542903.1	YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP)
YP_542905.1	thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate
YP_542911.1	YhhY; regulated by the fur regulator; unknown function
YP_542914.1	periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides
YP_542916.1	hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate
YP_542917.2	part of the UgpABCE glycerol-3-phosphate uptake system
YP_542918.1	with UgpABC is involved in uptake of glycerol-3-phosphate
YP_542919.1	with UgpEC is involved in the uptake of glycerol-3-phosphate
YP_542920.1	with UgpACE is involved in the uptake of glycerol-3-phosphate
YP_542921.2	with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine
YP_542922.1	Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine
YP_542923.1	Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine
YP_542924.1	LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter
YP_542936.1	binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters
YP_542937.2	ABC transporter, membrane protein
YP_542938.1	ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions
YP_542939.1	signal recognition protein receptor; functions in the targeting and insertion of membrane proteins
YP_542940.1	catalyzes the methylation of 16S rRNA at position G966
YP_542944.1	P-type ATPase involved in the export of lead, cadmium, zinc and mercury
YP_542946.1	TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs
YP_542951.1	synonym: b3475, yhhU
YP_542954.1	with NikACDE is involved in nickel transport into the cell
YP_542955.1	with NikABDE is involved in nickel transport into the cell
YP_542956.1	with NikABCE is involved in nickel transport into the cell
YP_542957.1	with NikABCD is involved with nickel transport into the cell
YP_542958.1	Inhibits transcription at high concentrations of nickel
YP_542965.1	class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis
YP_542973.1	ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress
YP_542975.1	member of the POT family of peptide transporters; probable proton-dependent peptide transporter function
YP_542976.2	predicted SAM-dependent methyltransferase
YP_542977.1	synonym: b3498, opdA
YP_542979.1	catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense
YP_542994.1	catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III
YP_542998.1	with HmuTU is involved in the transport of hemin
YP_542999.1	inner membrane protein involved in cell density-dependent acid resistance; part of the acid fitness island (AFI) of E. coli
YP_543001.1	inactive form
YP_543005.1	with MdtF and tolC is involved in resistance to rhodamine 6G, erythromycin, doxorubicin and other compounds
YP_543008.1	regulates genes in response to acid and/or during stationary phase
YP_543011.1	cytoplasmic; catalyzes the hydrolysis of trehalose to glucose
YP_543017.1	in Escherichia coli this protein is involved in flagellar function
YP_543020.1	involved in the transport of C4-dicarboxylates across the membrane
YP_543021.1	HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a  phosphodiesterase from E. coli
YP_543022.1	cellulose is produced by the multicellular morphotypes of E. coli and Salmonella typhimurium; the cellulose biosynthesis genes bcsA, bcsB, bcsZ and bcsC are constitutively transcribed, however, cellulose synthesis is dependent on the expression of adrA
YP_543023.1	catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans
YP_543024.1	binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP)
YP_543025.2	polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis
YP_543038.1	Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides
YP_543039.1	DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF
YP_543041.1	transports peptides consisting of two or three amino acids
YP_543045.2	catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide
YP_543048.2	constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine
YP_543058.1	glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_543059.1	glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_543065.2	catalyzes the interconversion of D-xylose to D-xylulose
YP_543066.1	periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity
YP_543067.1	with XylFH is part of the high affinity xylose ABC transporter
YP_543072.1	periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds
YP_543073.1	transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis
YP_543074.1	synonym: yiaI, b3573
YP_543076.1	NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate
YP_543079.1	membrane-spanning protein involved in uptake of 2,3-diketo-L-gulonate; part of the tri-partite ATP-independent periplasmic transport system (TRAP) YiaMNO
YP_543084.1	catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate
YP_543085.1	L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate
YP_543086.1	catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source
YP_543092.1	catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis
YP_543098.1	Acts as a repressor of the mtlAD operon
YP_543104.1	represses the lctPRD operon
YP_543105.1	flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration
YP_543106.1	member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates
YP_543107.1	catalyzes the O-acetylation of serine
YP_543108.1	catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate
YP_543110.1	molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA
YP_543116.2	catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
YP_543121.1	converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism
YP_543122.1	catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine
YP_543123.1	catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose
YP_543124.1	catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core
YP_543125.1	synonym: b3621, rfa-2, rfa2, waaC, yibC
YP_543129.1	synonym: b3625, waaY
YP_543130.1	synonym: b3626, waaJ, waaR
YP_543131.1	synonym: b3627, waaI, waaO
YP_543132.1	synonym: b3630, waaP
YP_543133.1	synonym: b3631, pcsA, waaG
YP_543135.1	catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A
YP_543136.1	Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA
YP_543137.1	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases
YP_543139.1	in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif
YP_543140.1	required for 70S ribosome assembly
YP_543141.1	Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase
YP_543142.1	catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine
YP_543143.1	catalyzes the formation of dUMP from dUTP
YP_543144.2	FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly
YP_543145.2	involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate
YP_543146.2	RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs
YP_543150.1	this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+
YP_543152.1	Essential for recycling GMP and indirectly, cGMP
YP_543153.1	promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
YP_543155.1	specifically modifies tRNA at position G18
YP_543156.2	catalyzes branch migration in Holliday junction intermediates
YP_543168.1	catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides
YP_543169.2	may be involved in the transport of galactosides-pentoses-hexuronides
YP_543176.2	experimental results in Escherichia coli suggest that this gene encodes an inosine export protein; member of major facilitator superfamily; MFS
YP_543179.1	catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type
YP_543180.1	cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate
YP_543181.1	membrane protein regulates uhpT expression
YP_543182.1	Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph
YP_543183.1	response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter
YP_543184.1	with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit
YP_543187.1	multidrug efflux protein involved in adaptation to low energy shock
YP_543191.1	uncharacterized member of the SSS superfamily of sodium-dependent solute transporters; unknown function
YP_543195.2	16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent
YP_543196.1	with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress
YP_543199.2	FAD/NAD(P)-binding domain
YP_543202.1	catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism
YP_543205.1	YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins
YP_543207.1	negatively supercoils closed circular double-stranded DNA
YP_543208.1	Required for DNA replication; binds preferentially to single-stranded, linear DNA
YP_543209.1	binds the polymerase to DNA and acts as a sliding clamp
YP_543210.1	binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.
YP_543212.1	in Escherichia coli transcription of this gene is enhanced by polyamines
YP_543213.1	protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates
YP_543216.1	functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria
YP_543217.1	in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE
YP_543219.1	tryptophan indole-lyase; catalyzes the formation of indole and pyruvate from tryptophan
YP_543220.1	tryptophan transporter of low affinity
YP_543221.1	Confers resistance to chloramphenicol
YP_543222.1	Involved in anaerobic NO protection
YP_543226.1	might be involved in hypersensitivity to nitrofurzone
YP_543231.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_543232.1	positive regulator of the beta-glucoside operon; transcriptional antiterminator
YP_543234.2	regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon
YP_543235.1	ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation
YP_543236.1	Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions
YP_543237.1	part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions
YP_543239.1	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
YP_543240.1	forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis
YP_543242.1	part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane
YP_543243.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit
YP_543244.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit
YP_543245.1	produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit
YP_543247.1	Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex
YP_543249.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.
YP_543250.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0
YP_543251.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0
YP_543252.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation
YP_543253.1	glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA
YP_543254.1	GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs
YP_543255.1	An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group
YP_543256.1	transcriptional repressor of asnA which codes for aspartate-ammonia ligase
YP_543257.1	catalyzes the formation of asparagine from aspartate and ammonia
YP_543258.1	contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA
YP_543259.1	interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase
YP_543260.1	Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH
YP_543261.1	cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source
YP_543262.1	with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain
YP_543263.1	functions to transport ribose at high affinity; forms a complex with RbsA2C2B
YP_543264.1	periplasmic substrate-binding component of the ATP-dependent ribose transport system
YP_543265.2	catalyzes the formation of D-ribose 5-phosphate from ribose
YP_543266.1	DNA-binding transcriptional repressor of ribose metabolism
YP_543272.1	Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon
YP_543274.1	among the AAA+ ATPases, the YifB protease belongs to the Helix 2 insert clade; unknown function
YP_543276.1	catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit
YP_543278.1	catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids
YP_543279.1	catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis
YP_543280.1	threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway
YP_543281.2	participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate
YP_543282.1	catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis
YP_543284.1	single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication
YP_543285.1	catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation
YP_543286.1	enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation
YP_543290.1	An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes
YP_543293.1	Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein
YP_543294.1	synonym: yifF, b3786, G7969, nfrC, wecB
YP_543295.1	catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid
YP_543296.1	synonym: rff, b3788, nfrC, rffE
YP_543297.1	synonym: b3789, yifG
YP_543298.1	synonym: rff, b3790, wecD, yifH
YP_543299.1	catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis
YP_543302.1	catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis
YP_543303.1	enterobacterial common antigen polymerase
YP_543304.1	synonym: rff, b3794, wecG
YP_543305.1	uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function
YP_543311.1	catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis
YP_543312.1	transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis
YP_543313.1	catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP
YP_543314.1	defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly
YP_543320.1	involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate
YP_543322.1	site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs
YP_543323.1	YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function
YP_543324.2	unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.
YP_543327.2	responsible for the influx of magnesium ions
YP_543332.1	catalyzes the hydrolysis of phosphatidylcholine
YP_543334.1	functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway
YP_543336.1	synonym: b3824, yigK
YP_543337.1	lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates
YP_543338.1	purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium
YP_543341.1	catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine
YP_543348.1	catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase
YP_543353.1	catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP
YP_543359.2	catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway
YP_543363.1	catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism
YP_543367.1	YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner
YP_543368.1	Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone
YP_543370.1	an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions
YP_543371.1	TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes
YP_543372.1	mediates the export of protein precursors bearing twin-arginine signal peptides
YP_543373.1	with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane
YP_543374.1	magnesium dependent; not involved in the Sec-independent protein export system
YP_543376.1	catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol
YP_543377.1	NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin
YP_543378.1	FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids
YP_543379.2	includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids
YP_543380.1	catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters
YP_543383.1	catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX
YP_543386.1	in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway
YP_543387.1	in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis
YP_543389.1	catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages
YP_543395.1	has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair
YP_543397.2	binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential
YP_543399.1	catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III
YP_543400.2	response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54
YP_543401.1	sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation
YP_543402.1	forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme
YP_543403.1	synonym: b3871, bipA, yihK, yjhK
YP_543413.1	RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease
YP_543414.1	hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine
YP_543421.1	required for the formation of active formate dehydrogenase
YP_543422.1	cytochrome b556(FDO) component; heme containing
YP_543425.1	involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth
YP_543429.1	catalyzes the formation of L-rhamnulose from L-rhamnose
YP_543430.1	catalyzes the ATP-dependent phosphorylation of rhamnulose
YP_543431.1	activates the expression of the rhaBAD operon and rhaT gene
YP_543432.1	activates the expression of rhaRS in response to L-rhamnose
YP_543433.1	transports L-rhamnose and L-lyxose into the cell
YP_543434.1	SodA; manganese binding; only present under aerobic conditions; destroys free radicals
YP_543436.2	transports degraded pectin products into the bacterial cell
YP_543438.1	part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors
YP_543439.1	response regulator in two-component regulatory system with CpxA; part of the envelope stress response system
YP_543440.2	repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates
YP_543441.2	member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers
YP_543442.1	catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis
YP_543446.1	Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate
YP_543450.1	with UspC and Usp E is involved in resistance to UV radiation
YP_543451.1	synonym: flxR, b3924, G7964, fruB, mvrA
YP_543452.1	type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese
YP_543453.1	Converts glycerol and ADP to glycerol-3-phosphate and ADP
YP_543456.1	regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity
YP_543458.1	catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate
YP_543459.1	heat shock protein involved in degradation of misfolded proteins
YP_543460.1	heat shock protein involved in degradation of misfolded proteins
YP_543462.1	negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins
YP_543463.1	binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity
YP_543465.1	member of the NlpC/P60 superfamily of peptidases
YP_543466.1	when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis
YP_543467.1	catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine
YP_543468.1	multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways
YP_543474.1	MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor
YP_543479.1	forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone
YP_543480.1	similar to transaldolase from Escherichia coli; many organisms have multiple copies
YP_543482.1	FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site
YP_543483.1	FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS
YP_543485.1	involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein
YP_543487.1	FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog
YP_543490.1	catalyzes the formation of oxaloacetate from phosphoenolpyruvate
YP_543491.1	catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis
YP_543492.1	catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate
YP_543493.1	catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate
YP_543494.1	catalyzes the formation of arginine from (N-L-arginino)succinate
YP_543497.2	Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA
YP_543498.1	catalyzes the conversion of NADPH to NADH
YP_543501.1	negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis
YP_543503.1	catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs
YP_543504.1	involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space
YP_543505.1	converts L-glutamate to D-glutamate, a component of peptidoglycan
YP_543511.1	catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis
YP_543512.1	Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle
YP_543514.1	catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol
YP_543515.2	regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase
YP_543516.1	one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity
YP_543520.1	alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family
YP_543527.1	Converts D-sorbitol-dphosphate to D-fructose-6-phosphate
YP_543529.1	catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA
YP_543531.1	catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive
YP_543532.1	functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family
YP_543541.1	with MalKFE is involved in the transport of maltose into the cell
YP_543542.1	with MalKGE is involved in maltose transport into the cell
YP_543543.1	functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis
YP_543544.1	with malEFG is involved in import of maltose/maltodextrin
YP_543545.1	porin involved in the transport of maltose and maltodextrins
YP_543548.1	catalyzes the formation of 4-hydroxybenzoate from chorismate
YP_543549.1	catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway
YP_543550.2	PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA
YP_543552.1	Represses a number of genes involved in the response to DNA damage
YP_543554.1	unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential
YP_543555.2	Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB
YP_543557.1	coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia
YP_543564.1	unwinds double stranded DNA
YP_543565.1	converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer
YP_543568.2	catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate
YP_543569.1	SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide
YP_543580.1	Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity
YP_543583.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YP_543584.2	binds to single stranded DNA and PriA helcase facilitate replication restart
YP_543587.1	regulates genes involved in response to oxidative stress
YP_543596.1	member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake
YP_543598.1	Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA
YP_543599.1	catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552
YP_543600.1	part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia
YP_543603.1	with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552
YP_543607.1	carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system
YP_543614.1	part of a multidrug efflux system involved in resistance to acriflavin, puromycin, erytjhromycin and tetraphenylarsonium chloride; member of the outer membrane factor (OMF) family
YP_543615.1	possibly part of a tripartite efflux system composed of MdtN, MdtO and MdtP which could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride
YP_543616.1	with MdtO and MdtP is involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride
YP_543621.1	with AlsBC acts to import allose into the cell; AlsA contain 2 ATP-binding domains
YP_543623.2	involved in rpiB and als operon repression
YP_543624.1	catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity
YP_543626.1	required for the use of phosphonates and phosphite as phosphorus sources
YP_543627.1	PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role
YP_543636.1	may be involved in phosphonate uptake and biodegradation
YP_543646.1	response regulator in two-component regulatory system with BasS
YP_543647.1	with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division
YP_543655.1	functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters
YP_543657.1	response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration
YP_543658.1	C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration
YP_543665.2	class II; inducible; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; induced by high temperature, anaerobiosis, and low pH; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1
YP_543668.1	antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein
YP_543669.1	regulates the cadBA operon
YP_543671.1	two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm
YP_543672.2	copper binding protein required for copper tolerance; involved in resistance toward heavy metals
YP_543673.1	functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB
YP_543674.1	catalyzes the formation of fumarate from aspartate
YP_543676.1	F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein
YP_543677.2	uncharacterized member of the APC superfamily of amino acid transporters; unknown function
YP_543678.1	10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring
YP_543679.1	60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth
YP_543683.1	Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA
YP_543684.1	acts as and antidote to the bacteriolytic entericidin B in the EcnAB toxin-antitoxin complex
YP_543687.1	lipocalin; globomycin-sensitive outer membrane lipoprotein
YP_543689.1	in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane
YP_543690.1	part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB
YP_543691.1	part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB
YP_543692.1	part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB
YP_543693.1	lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_543698.1	catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine
YP_543699.2	EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity
YP_543700.1	3'-5' exoribonuclease specific for small oligoribonuclotides
YP_543703.1	possibly involved in cell wall synthesis
YP_543705.1	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
YP_543706.1	IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity
YP_543707.1	Stimulates the elongation of poly(A) tails
YP_543708.1	involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein
YP_543709.1	with HflC inhibits proteolysis of lambda cII protein by FtsH
YP_543710.1	with HflK inhibits proteolysis of lambda cII protein by FtsH
YP_543712.1	catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis
YP_543713.1	negatively regulates the transcription of genes upregulated by nitrosative stress
YP_543714.2	3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs
YP_543715.1	Specifically methylates the ribose of guanosine 2251 in 23S rRNA
YP_543722.1	catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA
YP_543724.1	in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility
YP_543725.1	YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo
YP_543726.1	negative regulator of ulaG and ulaABCDEF
YP_543728.1	membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr
YP_543729.1	involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake
YP_543730.1	involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake
YP_543731.2	catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization
YP_543732.1	UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway
YP_543733.2	catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source
YP_543735.1	binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21
YP_543736.1	binds single-stranded DNA at the primosome assembly site
YP_543737.1	binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit
YP_543738.1	in Escherichia coli this protein is wrapped around the base of the L1 stalk
YP_543748.1	catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_543751.2	FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
YP_543752.1	involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine
YP_543753.1	Involved in anaerobic NO protection and iron metabolism
YP_543757.1	periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate
YP_543758.1	catalyzes the formation of AMP from adenosine-3',5'-bisphosphate
YP_543762.1	this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress
YP_543766.1	catalyzes the hydrolysis of pyrophosphate to phosphate
YP_543770.1	membrane component of a  sugar ABC transporter system
YP_543771.1	catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate
YP_543774.1	protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD
YP_543776.1	activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions
YP_543777.1	Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates
YP_543779.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_543780.1	regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon
YP_543782.1	P-type ATPase involved in magnesium influx
YP_543785.1	involved in the allosteric regulation of aspartate carbamoyltransferase
YP_543786.1	catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis
YP_543790.1	catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway
YP_543791.1	reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP
YP_543792.1	catalyzes the degradation of arginine to citruline and ammonia
YP_543795.1	catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase; when both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III
YP_543799.1	valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain
YP_543800.1	binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB
YP_543801.1	catalyzes the removal of N-terminal amino acids preferably leucine from various peptides
YP_543808.1	Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate
YP_543809.1	NAD-binding
YP_543889.1	catalyzes the formation of pyruvate from serine
YP_543890.1	member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function
YP_543891.1	regulates the synthesis and expression of the dsdXA operon and dadA gene
YP_543943.1	inversion of on/off regulator of fimA
YP_543944.1	inversion of on/off regulator of fimA
YP_543952.1	catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate
YP_543954.1	regulates the expression of uxuBA
YP_543955.1	inhibitor of RssB activity in response to DNA damage; blocks degradation of stationary phase sigma factor RpoS
YP_543957.1	with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone
YP_543958.1	with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase
YP_543959.1	forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone
YP_543966.1	catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate
YP_543967.1	Positively regulates the dhaKLM operon from a sigma-70 promoter
YP_543983.1	involved in the degradation of RNA; may be involved in the recycling of RNA during the SOS response
YP_543984.1	specificity determinant for hsdM and hsdR
YP_543987.1	restriction endonuclease; the EcoKI enzyme recognizes 5'-AACN(6)GTGC-3'; subunit R is required for both nuclease and ATPase activities
YP_543999.1	catalyzes the transfer of phosphoglycerol to the glucan backbone
YP_544001.1	acts to load the DnaB helicase onto the initiation site during DNA replication
YP_544002.1	This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'
YP_544006.2	regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin
YP_544010.1	16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit
YP_544012.1	with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB
YP_544013.1	alanine acetyltransferase that specifically acetylates ribosomal protein S18
YP_544014.1	manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily
YP_544075.1	stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein
YP_544083.1	catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate
YP_544084.2	Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
YP_544085.1	catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose
YP_544086.2	catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate
YP_544088.1	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes. Creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins
YP_544090.2	catalyzes the formation of serine from O-phosphoserine
YP_544091.1	Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents
YP_544092.1	catalyzes the formation of NAD(+) from nicotinamide ribonucleotide
YP_544095.1	ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence
YP_544096.1	catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan
YP_544097.1	When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription
YP_544098.1	pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog
YP_544099.1	catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate
YP_544102.1	response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation
YP_544103.1	part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation
YP_544107.1	member of the SPOUT superfamily of methyltransferases