-- dump date 20140619_091241 -- class Genbank::misc_feature -- table misc_feature_note -- id note 364106000001 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 364106000002 replication protein; Provisional; Region: PRK13702 364106000003 leader peptide RepL; Provisional; Region: PRK13716 364106000004 replication protein; Provisional; Region: PRK13750 364106000005 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 364106000006 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 364106000007 Integrase core domain; Region: rve; pfam00665 364106000008 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 364106000009 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 364106000010 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 364106000011 catalytic residues [active] 364106000012 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 364106000013 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 364106000014 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 364106000015 Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470 364106000016 Predicted membrane protein [Function unknown]; Region: COG4393 364106000017 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 364106000018 Uncharacterized conserved protein [Function unknown]; Region: COG3350 364106000019 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 364106000020 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 364106000021 FtsX-like permease family; Region: FtsX; pfam02687 364106000022 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 364106000023 FtsX-like permease family; Region: FtsX; pfam02687 364106000024 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 364106000025 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 364106000026 Walker A/P-loop; other site 364106000027 ATP binding site [chemical binding]; other site 364106000028 Q-loop/lid; other site 364106000029 ABC transporter signature motif; other site 364106000030 Walker B; other site 364106000031 D-loop; other site 364106000032 H-loop/switch region; other site 364106000033 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 364106000034 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 364106000035 catalytic residues [active] 364106000036 Transposase; Region: HTH_Tnp_1; cl17663 364106000037 Colicin E1 (microcin) immunity protein; Region: Microcin; pfam03526 364106000038 Protein of unknown function, DUF399; Region: DUF399; pfam04187 364106000039 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 364106000040 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 364106000041 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 364106000042 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 364106000043 Uncharacterized conserved protein [Function unknown]; Region: COG3391 364106000044 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 364106000045 Transposase; Region: HTH_Tnp_1; cl17663 364106000046 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 364106000047 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 364106000048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106000049 Walker A motif; other site 364106000050 ATP binding site [chemical binding]; other site 364106000051 Walker B motif; other site 364106000052 Integrase core domain; Region: rve; pfam00665 364106000053 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 364106000054 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 364106000055 putative active site [active] 364106000056 putative NTP binding site [chemical binding]; other site 364106000057 putative nucleic acid binding site [nucleotide binding]; other site 364106000058 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 364106000059 Transposase; Region: HTH_Tnp_1; pfam01527 364106000060 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 364106000061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 364106000062 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 364106000063 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 364106000064 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 364106000065 DNA-binding interface [nucleotide binding]; DNA binding site 364106000066 Integrase core domain; Region: rve; pfam00665 364106000067 transposase/IS protein; Provisional; Region: PRK09183 364106000068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106000069 Walker A motif; other site 364106000070 ATP binding site [chemical binding]; other site 364106000071 Walker B motif; other site 364106000072 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 364106000073 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 364106000074 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 364106000075 N-terminal plug; other site 364106000076 ligand-binding site [chemical binding]; other site 364106000077 IS2 repressor TnpA; Reviewed; Region: PRK09413 364106000078 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 364106000079 Adhesin biosynthesis transcription regulatory protein; Region: PapB; pfam03333 364106000080 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 364106000081 active site 364106000082 catalytic residues [active] 364106000083 DNA binding site [nucleotide binding] 364106000084 Int/Topo IB signature motif; other site 364106000085 plasmid maintenance protein CcdA; Provisional; Region: PRK13710 364106000086 plasmid maintenance protein CcdB; Provisional; Region: PRK13708 364106000087 Phage integrase family; Region: Phage_integrase; pfam00589 364106000088 active site 364106000089 DNA binding site [nucleotide binding] 364106000090 Int/Topo IB signature motif; other site 364106000091 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 364106000092 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 364106000093 ParA-like protein; Provisional; Region: PHA02518 364106000094 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 364106000095 P-loop; other site 364106000096 Magnesium ion binding site [ion binding]; other site 364106000097 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 364106000098 Mg binding site [ion binding]; other site 364106000099 nucleotide binding site [chemical binding]; other site 364106000100 putative protofilament interface [polypeptide binding]; other site 364106000101 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 364106000102 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 364106000103 Catalytic site [active] 364106000104 DinI-like family; Region: DinI; pfam06183 364106000105 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 364106000106 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 364106000107 Transposase; Region: DDE_Tnp_ISL3; pfam01610 364106000108 Protein of unknown function (DUF1281); Region: DUF1281; pfam06924 364106000109 transposase/IS protein; Provisional; Region: PRK09183 364106000110 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106000111 Walker A motif; other site 364106000112 ATP binding site [chemical binding]; other site 364106000113 Walker B motif; other site 364106000114 arginine finger; other site 364106000115 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 364106000116 Helix-turn-helix domain; Region: HTH_38; pfam13936 364106000117 Integrase core domain; Region: rve; pfam00665 364106000118 Integrase core domain; Region: rve_3; cl15866 364106000119 putative methylase; Provisional; Region: PRK13699 364106000120 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 364106000121 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 364106000122 Antirestriction protein; Region: Antirestrict; pfam03230 364106000123 Mu B transposition protein, C terminal; Region: Phage-MuB_C; pfam09077 364106000124 Domain of unknown function (DUF3560); Region: DUF3560; pfam12083 364106000125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106000126 S-adenosylmethionine binding site [chemical binding]; other site 364106000127 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 364106000128 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 364106000129 dimer interface [polypeptide binding]; other site 364106000130 ssDNA binding site [nucleotide binding]; other site 364106000131 tetramer (dimer of dimers) interface [polypeptide binding]; other site 364106000132 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 364106000133 ParB-like nuclease domain; Region: ParB; smart00470 364106000134 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 364106000135 KorB domain; Region: KorB; pfam08535 364106000136 plasmid SOS inhibition protein B; Provisional; Region: psiB; PRK13701 364106000137 plasmid SOS inhibition protein A; Provisional; Region: PRK13704 364106000138 modulator of post-segregation killing protein; Provisional; Region: PRK13720 364106000139 small toxic polypeptide; Provisional; Region: PRK09738 364106000140 Domain of unknown function (DUF932); Region: DUF932; pfam06067 364106000141 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 364106000142 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 364106000143 N-acetyl-D-glucosamine binding site [chemical binding]; other site 364106000144 catalytic residue [active] 364106000145 TraM protein; Region: Tra_M; pfam05261 364106000146 PAS fold; Region: PAS; pfam00989 364106000147 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 364106000148 conjugal transfer protein TraY; Provisional; Region: PRK13740 364106000149 conjugal transfer pilin subunit TraA; Provisional; Region: PRK13734 364106000150 conjugal transfer pilus assembly protein TraL; Provisional; Region: PRK13707 364106000151 conjugal transfer pilus assembly protein TraE; Provisional; Region: PRK13726 364106000152 conjugal transfer protein TraK; Provisional; Region: PRK13736 364106000153 TraK protein; Region: TraK; pfam06586 364106000154 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 364106000155 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 364106000156 conjugal transfer protein TraP; Provisional; Region: PRK13739 364106000157 conjugal transfer protein TrbD; Provisional; Region: PRK13724 364106000158 conjugal transfer protein TraV; Provisional; Region: PRK13733 364106000159 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 364106000160 conjugal transfer protein TraR; Provisional; Region: PRK13715 364106000161 conjugal transfer ATP-binding protein TraC; Provisional; Region: PRK13721 364106000162 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 364106000163 conjugal transfer protein TrbI; Provisional; Region: PRK13717 364106000164 conjugal transfer pilus assembly protein TraW; Provisional; Region: PRK13738 364106000165 conjugal transfer pilus assembly protein TraU; Provisional; Region: PRK13737 364106000166 conjugal transfer pilus assembly protein TrbC; Provisional; Region: PRK13730 364106000167 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 364106000168 conjugal transfer protein TrbE; Provisional; Region: PRK13718 364106000169 conjugal pilus assembly protein TraF; Provisional; Region: PRK13703 364106000170 F plasmid transfer operon protein; Region: TraF; pfam13728 364106000171 conjugal transfer protein TrbA; Provisional; Region: PRK13712 364106000172 conjugal transfer pilin chaperone TraQ; Provisional; Region: PRK13727 364106000173 conjugal transfer protein TrbB; Provisional; Region: PRK13728 364106000174 conjugal transfer protein TrbJ; Provisional; Region: PRK13711 364106000175 conjugal transfer protein TrbF; Provisional; Region: PRK13743 364106000176 conjugal transfer pilus assembly protein TraH; Provisional; Region: PRK13723 364106000177 conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735 364106000178 Plasmid conjugative transfer entry exclusion protein TraS; Region: TraS; pfam10624 364106000179 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 364106000180 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 364106000181 conjugal transfer protein TraD; Provisional; Region: PRK13700 364106000182 F sex factor protein N terminal; Region: TraD_N; pfam12615 364106000183 Bacterial conjugation protein TrwB, ATP binding domain. TrwB is a homohexamer encoded by conjugative plasmids in Gram-negative bacteria. TrwB also has an all alpha domain which has been hypothesized to be responsible for DNA binding. TrwB is a component...; Region: TrwB; cd01127 364106000184 multimer interface [polypeptide binding]; other site 364106000185 Walker A motif; other site 364106000186 ATP binding site [chemical binding]; other site 364106000187 Walker B motif; other site 364106000188 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 364106000189 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 364106000190 AAA domain; Region: AAA_30; pfam13604 364106000191 DNA helicase TraI; Region: TraI; pfam07057 364106000192 conjugal transfer pilus acetylation protein TraX; Provisional; Region: PRK13706 364106000193 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 364106000194 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 364106000195 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 364106000196 conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754 364106000197 Fertility inhibition protein N terminal; Region: FinO_N; pfam12602 364106000198 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 364106000199 putative RNA binding sites [nucleotide binding]; other site 364106000200 Staphylococcal nuclease homologues; Region: SNc; smart00318 364106000201 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 364106000202 Catalytic site; other site 364106000203 Haemolysin expression modulating protein; Region: HHA; pfam05321 364106000204 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 364106000205 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 364106000206 putative catalytic residues [active] 364106000207 putative nucleotide binding site [chemical binding]; other site 364106000208 putative aspartate binding site [chemical binding]; other site 364106000209 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 364106000210 dimer interface [polypeptide binding]; other site 364106000211 putative threonine allosteric regulatory site; other site 364106000212 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 364106000213 putative threonine allosteric regulatory site; other site 364106000214 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 364106000215 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 364106000216 homoserine kinase; Region: thrB; TIGR00191 364106000217 Protein of unknown function; Region: YhfT; pfam10797 364106000218 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 364106000219 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 364106000220 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 364106000221 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106000222 catalytic residue [active] 364106000223 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 364106000224 hypothetical protein; Validated; Region: PRK02101 364106000225 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 364106000226 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 364106000227 transaldolase-like protein; Provisional; Region: PTZ00411 364106000228 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 364106000229 active site 364106000230 dimer interface [polypeptide binding]; other site 364106000231 catalytic residue [active] 364106000232 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 364106000233 MPT binding site; other site 364106000234 trimer interface [polypeptide binding]; other site 364106000235 hypothetical protein; Provisional; Region: PRK10659 364106000236 hypothetical protein; Provisional; Region: PRK10236 364106000237 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 364106000238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 364106000239 hypothetical protein; Provisional; Region: PRK10154 364106000240 NAD-specific glutamate dehydrogenase; Region: NAD-GH; pfam10712 364106000241 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 364106000242 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 364106000243 nucleotide binding site [chemical binding]; other site 364106000244 NEF interaction site [polypeptide binding]; other site 364106000245 SBD interface [polypeptide binding]; other site 364106000246 chaperone protein DnaJ; Provisional; Region: PRK10767 364106000247 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 364106000248 HSP70 interaction site [polypeptide binding]; other site 364106000249 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 364106000250 substrate binding site [polypeptide binding]; other site 364106000251 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 364106000252 Zn binding sites [ion binding]; other site 364106000253 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 364106000254 dimer interface [polypeptide binding]; other site 364106000255 Hok/gef family; Region: HOK_GEF; pfam01848 364106000256 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 364106000257 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 364106000258 Sulfatase; Region: Sulfatase; pfam00884 364106000259 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 364106000260 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 364106000261 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106000262 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 364106000263 putative dimerization interface [polypeptide binding]; other site 364106000264 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 364106000265 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 364106000266 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 364106000267 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 364106000268 active site 364106000269 Riboflavin kinase; Region: Flavokinase; smart00904 364106000270 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 364106000271 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 364106000272 HIGH motif; other site 364106000273 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 364106000274 active site 364106000275 KMSKS motif; other site 364106000276 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 364106000277 tRNA binding surface [nucleotide binding]; other site 364106000278 anticodon binding site; other site 364106000279 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 364106000280 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 364106000281 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 364106000282 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 364106000283 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 364106000284 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 364106000285 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 364106000286 active site 364106000287 tetramer interface [polypeptide binding]; other site 364106000288 Protein of unknown function (DUF805); Region: DUF805; pfam05656 364106000289 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 364106000290 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 364106000291 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 364106000292 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 364106000293 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 364106000294 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 364106000295 catalytic site [active] 364106000296 subunit interface [polypeptide binding]; other site 364106000297 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 364106000298 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 364106000299 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 364106000300 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 364106000301 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 364106000302 ATP-grasp domain; Region: ATP-grasp_4; cl17255 364106000303 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 364106000304 IMP binding site; other site 364106000305 dimer interface [polypeptide binding]; other site 364106000306 interdomain contacts; other site 364106000307 partial ornithine binding site; other site 364106000308 Transposase IS200 like; Region: Y1_Tnp; pfam01797 364106000309 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 364106000310 carnitine operon protein CaiE; Provisional; Region: PRK13627 364106000311 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 364106000312 putative trimer interface [polypeptide binding]; other site 364106000313 putative metal binding site [ion binding]; other site 364106000314 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 364106000315 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 364106000316 substrate binding site [chemical binding]; other site 364106000317 oxyanion hole (OAH) forming residues; other site 364106000318 trimer interface [polypeptide binding]; other site 364106000319 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 364106000320 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 364106000321 acyl-activating enzyme (AAE) consensus motif; other site 364106000322 putative AMP binding site [chemical binding]; other site 364106000323 putative active site [active] 364106000324 putative CoA binding site [chemical binding]; other site 364106000325 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 364106000326 CoA-transferase family III; Region: CoA_transf_3; pfam02515 364106000327 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 364106000328 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 364106000329 active site 364106000330 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 364106000331 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 364106000332 Ligand binding site [chemical binding]; other site 364106000333 Electron transfer flavoprotein domain; Region: ETF; pfam01012 364106000334 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 364106000335 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 364106000336 Ligand binding site [chemical binding]; other site 364106000337 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 364106000338 putative oxidoreductase FixC; Provisional; Region: PRK10157 364106000339 ferredoxin-like protein FixX; Provisional; Region: PRK15449 364106000340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106000341 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 364106000342 putative substrate translocation pore; other site 364106000343 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 364106000344 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 364106000345 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 364106000346 TrkA-N domain; Region: TrkA_N; pfam02254 364106000347 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 364106000348 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 364106000349 folate binding site [chemical binding]; other site 364106000350 NADP+ binding site [chemical binding]; other site 364106000351 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 364106000352 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 364106000353 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 364106000354 active site 364106000355 metal binding site [ion binding]; metal-binding site 364106000356 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 364106000357 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 364106000358 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 364106000359 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 364106000360 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 364106000361 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 364106000362 SurA N-terminal domain; Region: SurA_N; pfam09312 364106000363 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 364106000364 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 364106000365 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 364106000366 OstA-like protein; Region: OstA; pfam03968 364106000367 Organic solvent tolerance protein; Region: OstA_C; pfam04453 364106000368 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 364106000369 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 364106000370 putative metal binding site [ion binding]; other site 364106000371 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 364106000372 HSP70 interaction site [polypeptide binding]; other site 364106000373 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 364106000374 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 364106000375 active site 364106000376 ATP-dependent helicase HepA; Validated; Region: PRK04914 364106000377 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 364106000378 ATP binding site [chemical binding]; other site 364106000379 putative Mg++ binding site [ion binding]; other site 364106000380 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 364106000381 nucleotide binding region [chemical binding]; other site 364106000382 ATP-binding site [chemical binding]; other site 364106000383 DNA polymerase II; Reviewed; Region: PRK05762 364106000384 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 364106000385 active site 364106000386 catalytic site [active] 364106000387 substrate binding site [chemical binding]; other site 364106000388 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 364106000389 active site 364106000390 metal-binding site 364106000391 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 364106000392 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 364106000393 intersubunit interface [polypeptide binding]; other site 364106000394 active site 364106000395 Zn2+ binding site [ion binding]; other site 364106000396 L-arabinose isomerase; Provisional; Region: PRK02929 364106000397 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 364106000398 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 364106000399 trimer interface [polypeptide binding]; other site 364106000400 putative substrate binding site [chemical binding]; other site 364106000401 putative metal binding site [ion binding]; other site 364106000402 ribulokinase; Provisional; Region: PRK04123 364106000403 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 364106000404 N- and C-terminal domain interface [polypeptide binding]; other site 364106000405 active site 364106000406 MgATP binding site [chemical binding]; other site 364106000407 catalytic site [active] 364106000408 metal binding site [ion binding]; metal-binding site 364106000409 carbohydrate binding site [chemical binding]; other site 364106000410 homodimer interface [polypeptide binding]; other site 364106000411 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 364106000412 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 364106000413 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106000414 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106000415 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 364106000416 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 364106000417 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 364106000418 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 364106000419 Walker A/P-loop; other site 364106000420 ATP binding site [chemical binding]; other site 364106000421 Q-loop/lid; other site 364106000422 ABC transporter signature motif; other site 364106000423 Walker B; other site 364106000424 D-loop; other site 364106000425 H-loop/switch region; other site 364106000426 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 364106000427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106000428 dimer interface [polypeptide binding]; other site 364106000429 conserved gate region; other site 364106000430 putative PBP binding loops; other site 364106000431 ABC-ATPase subunit interface; other site 364106000432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106000433 dimer interface [polypeptide binding]; other site 364106000434 conserved gate region; other site 364106000435 putative PBP binding loops; other site 364106000436 ABC-ATPase subunit interface; other site 364106000437 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 364106000438 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 364106000439 transcriptional regulator SgrR; Provisional; Region: PRK13626 364106000440 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 364106000441 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 364106000442 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 364106000443 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 364106000444 substrate binding site [chemical binding]; other site 364106000445 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 364106000446 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 364106000447 substrate binding site [chemical binding]; other site 364106000448 ligand binding site [chemical binding]; other site 364106000449 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 364106000450 tartrate dehydrogenase; Region: TTC; TIGR02089 364106000451 2-isopropylmalate synthase; Validated; Region: PRK00915 364106000452 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 364106000453 active site 364106000454 catalytic residues [active] 364106000455 metal binding site [ion binding]; metal-binding site 364106000456 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 364106000457 leu operon leader peptide; Provisional; Region: PRK09925 364106000458 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 364106000459 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106000460 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 364106000461 putative substrate binding pocket [chemical binding]; other site 364106000462 putative dimerization interface [polypeptide binding]; other site 364106000463 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 364106000464 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 364106000465 PYR/PP interface [polypeptide binding]; other site 364106000466 dimer interface [polypeptide binding]; other site 364106000467 TPP binding site [chemical binding]; other site 364106000468 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 364106000469 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 364106000470 TPP-binding site [chemical binding]; other site 364106000471 dimer interface [polypeptide binding]; other site 364106000472 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 364106000473 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 364106000474 putative valine binding site [chemical binding]; other site 364106000475 dimer interface [polypeptide binding]; other site 364106000476 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 364106000477 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 364106000478 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 364106000479 DNA binding site [nucleotide binding] 364106000480 domain linker motif; other site 364106000481 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 364106000482 dimerization interface [polypeptide binding]; other site 364106000483 ligand binding site [chemical binding]; other site 364106000484 mraZ protein; Region: TIGR00242 364106000485 MraZ protein; Region: MraZ; pfam02381 364106000486 MraZ protein; Region: MraZ; pfam02381 364106000487 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 364106000488 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 364106000489 cell division protein FtsL; Provisional; Region: PRK10772 364106000490 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 364106000491 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 364106000492 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 364106000493 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 364106000494 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 364106000495 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 364106000496 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 364106000497 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 364106000498 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 364106000499 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 364106000500 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 364106000501 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 364106000502 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 364106000503 Mg++ binding site [ion binding]; other site 364106000504 putative catalytic motif [active] 364106000505 putative substrate binding site [chemical binding]; other site 364106000506 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 364106000507 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 364106000508 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 364106000509 cell division protein FtsW; Provisional; Region: PRK10774 364106000510 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 364106000511 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 364106000512 active site 364106000513 homodimer interface [polypeptide binding]; other site 364106000514 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 364106000515 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 364106000516 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 364106000517 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 364106000518 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 364106000519 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 364106000520 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 364106000521 cell division protein FtsQ; Provisional; Region: PRK10775 364106000522 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 364106000523 Cell division protein FtsQ; Region: FtsQ; pfam03799 364106000524 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 364106000525 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 364106000526 Cell division protein FtsA; Region: FtsA; pfam14450 364106000527 cell division protein FtsZ; Validated; Region: PRK09330 364106000528 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 364106000529 nucleotide binding site [chemical binding]; other site 364106000530 SulA interaction site; other site 364106000531 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 364106000532 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 364106000533 SecA regulator SecM; Provisional; Region: PRK02943 364106000534 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 364106000535 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 364106000536 SEC-C motif; Region: SEC-C; pfam02810 364106000537 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 364106000538 active site 364106000539 8-oxo-dGMP binding site [chemical binding]; other site 364106000540 nudix motif; other site 364106000541 metal binding site [ion binding]; metal-binding site 364106000542 DNA gyrase inhibitor; Reviewed; Region: PRK00418 364106000543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 364106000544 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 364106000545 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 364106000546 CoA-binding site [chemical binding]; other site 364106000547 ATP-binding [chemical binding]; other site 364106000548 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 364106000549 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 364106000550 active site 364106000551 type IV pilin biogenesis protein; Provisional; Region: PRK10573 364106000552 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 364106000553 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 364106000554 hypothetical protein; Provisional; Region: PRK10436 364106000555 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 364106000556 Walker A motif; other site 364106000557 ATP binding site [chemical binding]; other site 364106000558 Walker B motif; other site 364106000559 putative major pilin subunit; Provisional; Region: PRK10574 364106000560 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 364106000561 Pilin (bacterial filament); Region: Pilin; pfam00114 364106000562 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 364106000563 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 364106000564 dimerization interface [polypeptide binding]; other site 364106000565 active site 364106000566 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 364106000567 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 364106000568 amidase catalytic site [active] 364106000569 Zn binding residues [ion binding]; other site 364106000570 substrate binding site [chemical binding]; other site 364106000571 regulatory protein AmpE; Provisional; Region: PRK10987 364106000572 aromatic amino acid transporter; Provisional; Region: PRK10238 364106000573 Protein of unknown function (DUF796); Region: DUF796; cl01226 364106000574 S-type Pyocin; Region: Pyocin_S; pfam06958 364106000575 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 364106000576 active site 364106000577 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 364106000578 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 364106000579 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 364106000580 Transcriptional regulators [Transcription]; Region: FadR; COG2186 364106000581 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 364106000582 DNA-binding site [nucleotide binding]; DNA binding site 364106000583 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 364106000584 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 364106000585 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 364106000586 dimer interface [polypeptide binding]; other site 364106000587 TPP-binding site [chemical binding]; other site 364106000588 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 364106000589 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 364106000590 E3 interaction surface; other site 364106000591 lipoyl attachment site [posttranslational modification]; other site 364106000592 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 364106000593 E3 interaction surface; other site 364106000594 lipoyl attachment site [posttranslational modification]; other site 364106000595 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 364106000596 E3 interaction surface; other site 364106000597 lipoyl attachment site [posttranslational modification]; other site 364106000598 e3 binding domain; Region: E3_binding; pfam02817 364106000599 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 364106000600 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 364106000601 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 364106000602 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 364106000603 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 364106000604 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 364106000605 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 364106000606 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 364106000607 substrate binding site [chemical binding]; other site 364106000608 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 364106000609 substrate binding site [chemical binding]; other site 364106000610 ligand binding site [chemical binding]; other site 364106000611 hypothetical protein; Provisional; Region: PRK05248 364106000612 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 364106000613 spermidine synthase; Provisional; Region: PRK00811 364106000614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106000615 S-adenosylmethionine binding site [chemical binding]; other site 364106000616 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 364106000617 multicopper oxidase; Provisional; Region: PRK10965 364106000618 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 364106000619 Multicopper oxidase; Region: Cu-oxidase; pfam00394 364106000620 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 364106000621 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 364106000622 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 364106000623 Trp docking motif [polypeptide binding]; other site 364106000624 putative active site [active] 364106000625 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 364106000626 active site 364106000627 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 364106000628 active site clefts [active] 364106000629 zinc binding site [ion binding]; other site 364106000630 dimer interface [polypeptide binding]; other site 364106000631 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 364106000632 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 364106000633 Walker A/P-loop; other site 364106000634 ATP binding site [chemical binding]; other site 364106000635 Q-loop/lid; other site 364106000636 ABC transporter signature motif; other site 364106000637 Walker B; other site 364106000638 D-loop; other site 364106000639 H-loop/switch region; other site 364106000640 inner membrane transport permease; Provisional; Region: PRK15066 364106000641 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 364106000642 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 364106000643 active pocket/dimerization site; other site 364106000644 active site 364106000645 phosphorylation site [posttranslational modification] 364106000646 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 364106000647 putative active site [active] 364106000648 putative metal binding site [ion binding]; other site 364106000649 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 364106000650 tetramerization interface [polypeptide binding]; other site 364106000651 active site 364106000652 Uncharacterized conserved protein [Function unknown]; Region: COG5464 364106000653 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 364106000654 pantoate--beta-alanine ligase; Region: panC; TIGR00018 364106000655 Pantoate-beta-alanine ligase; Region: PanC; cd00560 364106000656 active site 364106000657 ATP-binding site [chemical binding]; other site 364106000658 pantoate-binding site; other site 364106000659 HXXH motif; other site 364106000660 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 364106000661 oligomerization interface [polypeptide binding]; other site 364106000662 active site 364106000663 metal binding site [ion binding]; metal-binding site 364106000664 putative fimbrial-like adhesin protein; Provisional; Region: PRK09723 364106000665 putative fimbrial protein StaF; Provisional; Region: PRK15262 364106000666 putative fimbrial protein StaE; Provisional; Region: PRK15263 364106000667 Fimbrial protein; Region: Fimbrial; cl01416 364106000668 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 364106000669 PapC N-terminal domain; Region: PapC_N; pfam13954 364106000670 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 364106000671 PapC C-terminal domain; Region: PapC_C; pfam13953 364106000672 putative chaperone protein EcpD; Provisional; Region: PRK09926 364106000673 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 364106000674 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 364106000675 Fimbrial protein; Region: Fimbrial; cl01416 364106000676 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 364106000677 catalytic center binding site [active] 364106000678 ATP binding site [chemical binding]; other site 364106000679 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 364106000680 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 364106000681 active site 364106000682 NTP binding site [chemical binding]; other site 364106000683 metal binding triad [ion binding]; metal-binding site 364106000684 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 364106000685 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 364106000686 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 364106000687 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 364106000688 active site 364106000689 nucleotide binding site [chemical binding]; other site 364106000690 HIGH motif; other site 364106000691 KMSKS motif; other site 364106000692 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 364106000693 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 364106000694 2'-5' RNA ligase; Provisional; Region: PRK15124 364106000695 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 364106000696 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 364106000697 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 364106000698 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 364106000699 ATP binding site [chemical binding]; other site 364106000700 putative Mg++ binding site [ion binding]; other site 364106000701 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 364106000702 nucleotide binding region [chemical binding]; other site 364106000703 ATP-binding site [chemical binding]; other site 364106000704 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 364106000705 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 364106000706 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 364106000707 Transglycosylase; Region: Transgly; pfam00912 364106000708 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 364106000709 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 364106000710 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 364106000711 N-terminal plug; other site 364106000712 ligand-binding site [chemical binding]; other site 364106000713 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 364106000714 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 364106000715 Walker A/P-loop; other site 364106000716 ATP binding site [chemical binding]; other site 364106000717 Q-loop/lid; other site 364106000718 ABC transporter signature motif; other site 364106000719 Walker B; other site 364106000720 D-loop; other site 364106000721 H-loop/switch region; other site 364106000722 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 364106000723 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 364106000724 siderophore binding site; other site 364106000725 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 364106000726 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 364106000727 ABC-ATPase subunit interface; other site 364106000728 dimer interface [polypeptide binding]; other site 364106000729 putative PBP binding regions; other site 364106000730 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 364106000731 ABC-ATPase subunit interface; other site 364106000732 dimer interface [polypeptide binding]; other site 364106000733 putative PBP binding regions; other site 364106000734 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 364106000735 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 364106000736 inhibitor-cofactor binding pocket; inhibition site 364106000737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106000738 catalytic residue [active] 364106000739 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 364106000740 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 364106000741 Cl- selectivity filter; other site 364106000742 Cl- binding residues [ion binding]; other site 364106000743 pore gating glutamate residue; other site 364106000744 dimer interface [polypeptide binding]; other site 364106000745 H+/Cl- coupling transport residue; other site 364106000746 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 364106000747 hypothetical protein; Provisional; Region: PRK10578 364106000748 UPF0126 domain; Region: UPF0126; pfam03458 364106000749 UPF0126 domain; Region: UPF0126; pfam03458 364106000750 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 364106000751 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 364106000752 cobalamin binding residues [chemical binding]; other site 364106000753 putative BtuC binding residues; other site 364106000754 dimer interface [polypeptide binding]; other site 364106000755 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 364106000756 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 364106000757 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 364106000758 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 364106000759 Zn2+ binding site [ion binding]; other site 364106000760 Mg2+ binding site [ion binding]; other site 364106000761 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 364106000762 serine endoprotease; Provisional; Region: PRK10942 364106000763 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 364106000764 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 364106000765 protein binding site [polypeptide binding]; other site 364106000766 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 364106000767 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 364106000768 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 364106000769 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 364106000770 hypothetical protein; Provisional; Region: PRK13677 364106000771 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 364106000772 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 364106000773 trimer interface [polypeptide binding]; other site 364106000774 active site 364106000775 substrate binding site [chemical binding]; other site 364106000776 CoA binding site [chemical binding]; other site 364106000777 PII uridylyl-transferase; Provisional; Region: PRK05007 364106000778 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 364106000779 metal binding triad; other site 364106000780 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 364106000781 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 364106000782 Zn2+ binding site [ion binding]; other site 364106000783 Mg2+ binding site [ion binding]; other site 364106000784 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 364106000785 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 364106000786 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 364106000787 active site 364106000788 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 364106000789 rRNA interaction site [nucleotide binding]; other site 364106000790 S8 interaction site; other site 364106000791 putative laminin-1 binding site; other site 364106000792 elongation factor Ts; Provisional; Region: tsf; PRK09377 364106000793 UBA/TS-N domain; Region: UBA; pfam00627 364106000794 Elongation factor TS; Region: EF_TS; pfam00889 364106000795 Elongation factor TS; Region: EF_TS; pfam00889 364106000796 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 364106000797 putative nucleotide binding site [chemical binding]; other site 364106000798 uridine monophosphate binding site [chemical binding]; other site 364106000799 homohexameric interface [polypeptide binding]; other site 364106000800 ribosome recycling factor; Reviewed; Region: frr; PRK00083 364106000801 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 364106000802 hinge region; other site 364106000803 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 364106000804 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 364106000805 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 364106000806 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 364106000807 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 364106000808 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 364106000809 catalytic residue [active] 364106000810 putative FPP diphosphate binding site; other site 364106000811 putative FPP binding hydrophobic cleft; other site 364106000812 dimer interface [polypeptide binding]; other site 364106000813 putative IPP diphosphate binding site; other site 364106000814 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 364106000815 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 364106000816 zinc metallopeptidase RseP; Provisional; Region: PRK10779 364106000817 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 364106000818 active site 364106000819 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 364106000820 protein binding site [polypeptide binding]; other site 364106000821 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 364106000822 putative substrate binding region [chemical binding]; other site 364106000823 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 364106000824 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 364106000825 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 364106000826 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 364106000827 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 364106000828 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 364106000829 Surface antigen; Region: Bac_surface_Ag; pfam01103 364106000830 periplasmic chaperone; Provisional; Region: PRK10780 364106000831 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 364106000832 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 364106000833 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 364106000834 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 364106000835 trimer interface [polypeptide binding]; other site 364106000836 active site 364106000837 UDP-GlcNAc binding site [chemical binding]; other site 364106000838 lipid binding site [chemical binding]; lipid-binding site 364106000839 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 364106000840 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 364106000841 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 364106000842 active site 364106000843 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 364106000844 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 364106000845 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 364106000846 RNA/DNA hybrid binding site [nucleotide binding]; other site 364106000847 active site 364106000848 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 364106000849 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 364106000850 putative active site [active] 364106000851 putative PHP Thumb interface [polypeptide binding]; other site 364106000852 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 364106000853 generic binding surface II; other site 364106000854 generic binding surface I; other site 364106000855 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 364106000856 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 364106000857 lysine decarboxylase LdcC; Provisional; Region: PRK15399 364106000858 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 364106000859 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 364106000860 homodimer interface [polypeptide binding]; other site 364106000861 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106000862 catalytic residue [active] 364106000863 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 364106000864 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 364106000865 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 364106000866 putative metal binding site [ion binding]; other site 364106000867 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 364106000868 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 364106000869 Ligand Binding Site [chemical binding]; other site 364106000870 TilS substrate binding domain; Region: TilS; pfam09179 364106000871 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 364106000872 Rho-binding antiterminator; Provisional; Region: PRK11625 364106000873 hypothetical protein; Provisional; Region: PRK04964 364106000874 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 364106000875 hypothetical protein; Provisional; Region: PRK09256 364106000876 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 364106000877 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 364106000878 NlpE N-terminal domain; Region: NlpE; pfam04170 364106000879 hypothetical protein; Provisional; Region: PRK11479 364106000880 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 364106000881 prolyl-tRNA synthetase; Provisional; Region: PRK09194 364106000882 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 364106000883 dimer interface [polypeptide binding]; other site 364106000884 motif 1; other site 364106000885 active site 364106000886 motif 2; other site 364106000887 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 364106000888 putative deacylase active site [active] 364106000889 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 364106000890 active site 364106000891 motif 3; other site 364106000892 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 364106000893 anticodon binding site; other site 364106000894 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 364106000895 homodimer interaction site [polypeptide binding]; other site 364106000896 cofactor binding site; other site 364106000897 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 364106000898 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 364106000899 lipoprotein, YaeC family; Region: TIGR00363 364106000900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106000901 dimer interface [polypeptide binding]; other site 364106000902 conserved gate region; other site 364106000903 ABC-ATPase subunit interface; other site 364106000904 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 364106000905 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 364106000906 Walker A/P-loop; other site 364106000907 ATP binding site [chemical binding]; other site 364106000908 Q-loop/lid; other site 364106000909 ABC transporter signature motif; other site 364106000910 Walker B; other site 364106000911 D-loop; other site 364106000912 H-loop/switch region; other site 364106000913 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 364106000914 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 364106000915 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 364106000916 active site 364106000917 motif I; other site 364106000918 motif II; other site 364106000919 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 364106000920 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 364106000921 active site 364106000922 catalytic tetrad [active] 364106000923 Transcriptional regulator [Transcription]; Region: LysR; COG0583 364106000924 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106000925 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 364106000926 putative effector binding pocket; other site 364106000927 dimerization interface [polypeptide binding]; other site 364106000928 hypothetical protein; Provisional; Region: PRK05421 364106000929 putative catalytic site [active] 364106000930 putative metal binding site [ion binding]; other site 364106000931 putative phosphate binding site [ion binding]; other site 364106000932 putative catalytic site [active] 364106000933 putative phosphate binding site [ion binding]; other site 364106000934 putative metal binding site [ion binding]; other site 364106000935 Methyltransferase domain; Region: Methyltransf_31; pfam13847 364106000936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106000937 S-adenosylmethionine binding site [chemical binding]; other site 364106000938 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 364106000939 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 364106000940 N-acetyl-D-glucosamine binding site [chemical binding]; other site 364106000941 catalytic residue [active] 364106000942 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 364106000943 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 364106000944 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 364106000945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106000946 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 364106000947 RNA/DNA hybrid binding site [nucleotide binding]; other site 364106000948 active site 364106000949 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 364106000950 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 364106000951 active site 364106000952 catalytic site [active] 364106000953 substrate binding site [chemical binding]; other site 364106000954 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 364106000955 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 364106000956 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 364106000957 ImpA domain protein; Region: DUF3702; pfam12486 364106000958 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 364106000959 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 364106000960 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 364106000961 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 364106000962 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 364106000963 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 364106000964 type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360 364106000965 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 364106000966 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106000967 Walker A motif; other site 364106000968 ATP binding site [chemical binding]; other site 364106000969 Walker B motif; other site 364106000970 arginine finger; other site 364106000971 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106000972 Walker A motif; other site 364106000973 ATP binding site [chemical binding]; other site 364106000974 Walker B motif; other site 364106000975 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 364106000976 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 364106000977 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 364106000978 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 364106000979 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 364106000980 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 364106000981 FHA domain; Region: FHA; pfam00498 364106000982 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 364106000983 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 364106000984 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 364106000985 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 364106000986 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 364106000987 Protein of unknown function (DUF877); Region: DUF877; pfam05943 364106000988 Protein of unknown function (DUF770); Region: DUF770; pfam05591 364106000989 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 364106000990 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 364106000991 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 364106000992 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 364106000993 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 364106000994 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 364106000995 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 364106000996 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 364106000997 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 364106000998 putative active site [active] 364106000999 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 364106001000 C-N hydrolase family amidase; Provisional; Region: PRK10438 364106001001 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 364106001002 putative active site [active] 364106001003 catalytic triad [active] 364106001004 dimer interface [polypeptide binding]; other site 364106001005 multimer interface [polypeptide binding]; other site 364106001006 C-lysozyme inhibitor; Provisional; Region: PRK09993 364106001007 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 364106001008 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 364106001009 active site 364106001010 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 364106001011 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 364106001012 dimer interface [polypeptide binding]; other site 364106001013 active site 364106001014 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 364106001015 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 364106001016 putative active site [active] 364106001017 putative dimer interface [polypeptide binding]; other site 364106001018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 364106001019 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 364106001020 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 364106001021 NlpC/P60 family; Region: NLPC_P60; pfam00877 364106001022 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 364106001023 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 364106001024 FHIPEP family; Region: FHIPEP; pfam00771 364106001025 hypothetical protein; Validated; Region: PRK06778 364106001026 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 364106001027 ligand binding site [chemical binding]; other site 364106001028 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 364106001029 active site 364106001030 DNA polymerase IV; Validated; Region: PRK02406 364106001031 DNA binding site [nucleotide binding] 364106001032 putative antitoxin of the YafO-YafN toxin-antitoxin system; Provisional; Region: PRK09778 364106001033 putative toxin YafO; Provisional; Region: PRK09885 364106001034 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 364106001035 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 364106001036 Coenzyme A binding pocket [chemical binding]; other site 364106001037 hypothetical protein; Reviewed; Region: PRK09588 364106001038 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 364106001039 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 364106001040 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 364106001041 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 364106001042 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 364106001043 metal binding site [ion binding]; metal-binding site 364106001044 dimer interface [polypeptide binding]; other site 364106001045 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 364106001046 active site 364106001047 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 364106001048 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 364106001049 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 364106001050 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 364106001051 trimer interface [polypeptide binding]; other site 364106001052 eyelet of channel; other site 364106001053 gamma-glutamyl kinase; Provisional; Region: PRK05429 364106001054 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 364106001055 nucleotide binding site [chemical binding]; other site 364106001056 homotetrameric interface [polypeptide binding]; other site 364106001057 putative phosphate binding site [ion binding]; other site 364106001058 putative allosteric binding site; other site 364106001059 PUA domain; Region: PUA; pfam01472 364106001060 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 364106001061 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 364106001062 putative catalytic cysteine [active] 364106001063 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 364106001064 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 364106001065 Int/Topo IB signature motif; other site 364106001066 NIPSNAP; Region: NIPSNAP; pfam07978 364106001067 Part of AAA domain; Region: AAA_19; pfam13245 364106001068 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 364106001069 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 364106001070 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 364106001071 putative active site [active] 364106001072 putative metal-binding site [ion binding]; other site 364106001073 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 364106001074 multiple promoter invertase; Provisional; Region: mpi; PRK13413 364106001075 catalytic residues [active] 364106001076 catalytic nucleophile [active] 364106001077 Presynaptic Site I dimer interface [polypeptide binding]; other site 364106001078 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 364106001079 Synaptic Flat tetramer interface [polypeptide binding]; other site 364106001080 Synaptic Site I dimer interface [polypeptide binding]; other site 364106001081 DNA binding site [nucleotide binding] 364106001082 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 364106001083 DNA-binding interface [nucleotide binding]; DNA binding site 364106001084 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 364106001085 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 364106001086 non-specific DNA binding site [nucleotide binding]; other site 364106001087 salt bridge; other site 364106001088 sequence-specific DNA binding site [nucleotide binding]; other site 364106001089 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 364106001090 MarR family; Region: MarR_2; cl17246 364106001091 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 364106001092 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 364106001093 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 364106001094 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 364106001095 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 364106001096 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 364106001097 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 364106001098 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 364106001099 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 364106001100 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 364106001101 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 364106001102 DNA binding residues [nucleotide binding] 364106001103 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 364106001104 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 364106001105 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 364106001106 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 364106001107 putative active site [active] 364106001108 putative FMN binding site [chemical binding]; other site 364106001109 putative substrate binding site [chemical binding]; other site 364106001110 putative catalytic residue [active] 364106001111 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 364106001112 Transcriptional regulator [Transcription]; Region: LysR; COG0583 364106001113 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106001114 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 364106001115 putative effector binding pocket; other site 364106001116 putative dimerization interface [polypeptide binding]; other site 364106001117 Transcriptional regulator [Transcription]; Region: LysR; COG0583 364106001118 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106001119 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 364106001120 putative effector binding pocket; other site 364106001121 putative dimerization interface [polypeptide binding]; other site 364106001122 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 364106001123 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 364106001124 active site 364106001125 catalytic tetrad [active] 364106001126 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 364106001127 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 364106001128 active site 364106001129 catalytic tetrad [active] 364106001130 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 364106001131 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 364106001132 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 364106001133 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 364106001134 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 364106001135 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 364106001136 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106001137 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 364106001138 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 364106001139 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 364106001140 active site 364106001141 catalytic tetrad [active] 364106001142 Predicted membrane protein [Function unknown]; Region: COG3059 364106001143 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 364106001144 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 364106001145 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 364106001146 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 364106001147 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 364106001148 Cupin; Region: Cupin_6; pfam12852 364106001149 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 364106001150 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106001151 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 364106001152 Cysteine-rich domain; Region: CCG; pfam02754 364106001153 Cysteine-rich domain; Region: CCG; pfam02754 364106001154 iron-sulfur cluster-binding protein; Region: TIGR00273 364106001155 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 364106001156 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 364106001157 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 364106001158 Uncharacterized conserved protein [Function unknown]; Region: COG1556 364106001159 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 364106001160 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 364106001161 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 364106001162 Autotransporter beta-domain; Region: Autotransporter; pfam03797 364106001163 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 364106001164 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 364106001165 DNA binding residues [nucleotide binding] 364106001166 dimerization interface [polypeptide binding]; other site 364106001167 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 364106001168 active site 364106001169 DNA binding site [nucleotide binding] 364106001170 Int/Topo IB signature motif; other site 364106001171 choline dehydrogenase; Validated; Region: PRK02106 364106001172 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 364106001173 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 364106001174 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 364106001175 tetrameric interface [polypeptide binding]; other site 364106001176 NAD binding site [chemical binding]; other site 364106001177 catalytic residues [active] 364106001178 transcriptional regulator BetI; Validated; Region: PRK00767 364106001179 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 364106001180 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 364106001181 choline transport protein BetT; Provisional; Region: PRK09928 364106001182 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 364106001183 DNA binding residues [nucleotide binding] 364106001184 dimerization interface [polypeptide binding]; other site 364106001185 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 364106001186 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 364106001187 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106001188 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 364106001189 dimerization interface [polypeptide binding]; other site 364106001190 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 364106001191 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 364106001192 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 364106001193 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 364106001194 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 364106001195 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 364106001196 CoA binding domain; Region: CoA_binding; pfam02629 364106001197 CoA-ligase; Region: Ligase_CoA; pfam00549 364106001198 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 364106001199 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 364106001200 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 364106001201 putative substrate binding site [chemical binding]; other site 364106001202 nucleotide binding site [chemical binding]; other site 364106001203 nucleotide binding site [chemical binding]; other site 364106001204 homodimer interface [polypeptide binding]; other site 364106001205 putative deaminase; Validated; Region: PRK06846 364106001206 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 364106001207 active site 364106001208 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 364106001209 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 364106001210 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 364106001211 ligand binding site [chemical binding]; other site 364106001212 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 364106001213 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 364106001214 Walker A/P-loop; other site 364106001215 ATP binding site [chemical binding]; other site 364106001216 Q-loop/lid; other site 364106001217 ABC transporter signature motif; other site 364106001218 Walker B; other site 364106001219 D-loop; other site 364106001220 H-loop/switch region; other site 364106001221 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 364106001222 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 364106001223 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 364106001224 TM-ABC transporter signature motif; other site 364106001225 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 364106001226 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 364106001227 TM-ABC transporter signature motif; other site 364106001228 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 364106001229 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 364106001230 putative NAD(P) binding site [chemical binding]; other site 364106001231 putative substrate binding site [chemical binding]; other site 364106001232 catalytic Zn binding site [ion binding]; other site 364106001233 structural Zn binding site [ion binding]; other site 364106001234 dimer interface [polypeptide binding]; other site 364106001235 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 364106001236 hypothetical protein; Provisional; Region: PRK09929 364106001237 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 364106001238 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 364106001239 tetramer interface [polypeptide binding]; other site 364106001240 active site 364106001241 Mg2+/Mn2+ binding site [ion binding]; other site 364106001242 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 364106001243 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 364106001244 dimer interface [polypeptide binding]; other site 364106001245 active site 364106001246 citrylCoA binding site [chemical binding]; other site 364106001247 oxalacetate/citrate binding site [chemical binding]; other site 364106001248 coenzyme A binding site [chemical binding]; other site 364106001249 catalytic triad [active] 364106001250 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 364106001251 2-methylcitrate dehydratase; Region: prpD; TIGR02330 364106001252 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 364106001253 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 364106001254 acyl-activating enzyme (AAE) consensus motif; other site 364106001255 putative AMP binding site [chemical binding]; other site 364106001256 putative active site [active] 364106001257 putative CoA binding site [chemical binding]; other site 364106001258 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 364106001259 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 364106001260 Na binding site [ion binding]; other site 364106001261 putative substrate binding site [chemical binding]; other site 364106001262 cytosine deaminase; Provisional; Region: PRK09230 364106001263 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 364106001264 active site 364106001265 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 364106001266 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 364106001267 active site 364106001268 substrate binding site [chemical binding]; other site 364106001269 trimer interface [polypeptide binding]; other site 364106001270 CoA binding site [chemical binding]; other site 364106001271 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 364106001272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106001273 putative substrate translocation pore; other site 364106001274 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 364106001275 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 364106001276 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 364106001277 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 364106001278 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 364106001279 lac repressor; Reviewed; Region: lacI; PRK09526 364106001280 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 364106001281 DNA binding site [nucleotide binding] 364106001282 domain linker motif; other site 364106001283 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 364106001284 ligand binding site [chemical binding]; other site 364106001285 dimerization interface (open form) [polypeptide binding]; other site 364106001286 dimerization interface (closed form) [polypeptide binding]; other site 364106001287 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 364106001288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 364106001289 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 364106001290 S-formylglutathione hydrolase; Region: PLN02442 364106001291 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 364106001292 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 364106001293 substrate binding site [chemical binding]; other site 364106001294 catalytic Zn binding site [ion binding]; other site 364106001295 NAD binding site [chemical binding]; other site 364106001296 structural Zn binding site [ion binding]; other site 364106001297 dimer interface [polypeptide binding]; other site 364106001298 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 364106001299 putative metal binding site [ion binding]; other site 364106001300 putative homodimer interface [polypeptide binding]; other site 364106001301 putative homotetramer interface [polypeptide binding]; other site 364106001302 putative homodimer-homodimer interface [polypeptide binding]; other site 364106001303 putative allosteric switch controlling residues; other site 364106001304 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 364106001305 putative trimer interface [polypeptide binding]; other site 364106001306 putative CoA binding site [chemical binding]; other site 364106001307 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 364106001308 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 364106001309 DXD motif; other site 364106001310 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 364106001311 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 364106001312 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 364106001313 substrate binding pocket [chemical binding]; other site 364106001314 membrane-bound complex binding site; other site 364106001315 hinge residues; other site 364106001316 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 364106001317 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 364106001318 Walker A/P-loop; other site 364106001319 ATP binding site [chemical binding]; other site 364106001320 Q-loop/lid; other site 364106001321 ABC transporter signature motif; other site 364106001322 Walker B; other site 364106001323 D-loop; other site 364106001324 H-loop/switch region; other site 364106001325 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 364106001326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106001327 dimer interface [polypeptide binding]; other site 364106001328 conserved gate region; other site 364106001329 putative PBP binding loops; other site 364106001330 ABC-ATPase subunit interface; other site 364106001331 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 364106001332 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 364106001333 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 364106001334 dimer interface [polypeptide binding]; other site 364106001335 active site 364106001336 Schiff base residues; other site 364106001337 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 364106001338 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 364106001339 Autotransporter beta-domain; Region: Autotransporter; pfam03797 364106001340 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 364106001341 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 364106001342 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 364106001343 microcin B17 transporter; Reviewed; Region: PRK11098 364106001344 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 364106001345 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 364106001346 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 364106001347 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 364106001348 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 364106001349 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 364106001350 anti-RssB factor; Provisional; Region: PRK10244 364106001351 alkaline phosphatase; Provisional; Region: PRK10518 364106001352 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 364106001353 dimer interface [polypeptide binding]; other site 364106001354 active site 364106001355 hypothetical protein; Provisional; Region: PRK11505 364106001356 psiF repeat; Region: PsiF_repeat; pfam07769 364106001357 psiF repeat; Region: PsiF_repeat; pfam07769 364106001358 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 364106001359 MASE2 domain; Region: MASE2; pfam05230 364106001360 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 364106001361 metal binding site [ion binding]; metal-binding site 364106001362 active site 364106001363 I-site; other site 364106001364 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 364106001365 pyrroline-5-carboxylate reductase; Region: PLN02688 364106001366 hypothetical protein; Validated; Region: PRK00124 364106001367 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 364106001368 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 364106001369 ADP binding site [chemical binding]; other site 364106001370 magnesium binding site [ion binding]; other site 364106001371 putative shikimate binding site; other site 364106001372 hypothetical protein; Provisional; Region: PRK10380 364106001373 hypothetical protein; Provisional; Region: PRK10481 364106001374 hypothetical protein; Provisional; Region: PRK10579 364106001375 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 364106001376 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 364106001377 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 364106001378 fructokinase; Reviewed; Region: PRK09557 364106001379 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 364106001380 nucleotide binding site [chemical binding]; other site 364106001381 MFS transport protein AraJ; Provisional; Region: PRK10091 364106001382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106001383 putative substrate translocation pore; other site 364106001384 exonuclease subunit SbcC; Provisional; Region: PRK10246 364106001385 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 364106001386 Walker A/P-loop; other site 364106001387 ATP binding site [chemical binding]; other site 364106001388 Q-loop/lid; other site 364106001389 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 364106001390 ABC transporter signature motif; other site 364106001391 Walker B; other site 364106001392 D-loop; other site 364106001393 H-loop/switch region; other site 364106001394 exonuclease subunit SbcD; Provisional; Region: PRK10966 364106001395 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 364106001396 active site 364106001397 metal binding site [ion binding]; metal-binding site 364106001398 DNA binding site [nucleotide binding] 364106001399 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 364106001400 transcriptional regulator PhoB; Provisional; Region: PRK10161 364106001401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106001402 active site 364106001403 phosphorylation site [posttranslational modification] 364106001404 intermolecular recognition site; other site 364106001405 dimerization interface [polypeptide binding]; other site 364106001406 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 364106001407 DNA binding site [nucleotide binding] 364106001408 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 364106001409 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 364106001410 PAS domain; Region: PAS; smart00091 364106001411 putative active site [active] 364106001412 heme pocket [chemical binding]; other site 364106001413 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 364106001414 dimer interface [polypeptide binding]; other site 364106001415 phosphorylation site [posttranslational modification] 364106001416 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106001417 ATP binding site [chemical binding]; other site 364106001418 Mg2+ binding site [ion binding]; other site 364106001419 G-X-G motif; other site 364106001420 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 364106001421 putative proline-specific permease; Provisional; Region: proY; PRK10580 364106001422 Spore germination protein; Region: Spore_permease; cl17796 364106001423 maltodextrin glucosidase; Provisional; Region: PRK10785 364106001424 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 364106001425 homodimer interface [polypeptide binding]; other site 364106001426 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 364106001427 active site 364106001428 homodimer interface [polypeptide binding]; other site 364106001429 catalytic site [active] 364106001430 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 364106001431 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 364106001432 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 364106001433 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 364106001434 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 364106001435 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 364106001436 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 364106001437 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 364106001438 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 364106001439 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 364106001440 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 364106001441 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 364106001442 Protein export membrane protein; Region: SecD_SecF; pfam02355 364106001443 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 364106001444 active site 364106001445 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 364106001446 hypothetical protein; Provisional; Region: PRK11530 364106001447 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 364106001448 ATP cone domain; Region: ATP-cone; pfam03477 364106001449 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 364106001450 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 364106001451 catalytic motif [active] 364106001452 Zn binding site [ion binding]; other site 364106001453 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 364106001454 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 364106001455 homopentamer interface [polypeptide binding]; other site 364106001456 active site 364106001457 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 364106001458 putative RNA binding site [nucleotide binding]; other site 364106001459 thiamine monophosphate kinase; Provisional; Region: PRK05731 364106001460 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 364106001461 ATP binding site [chemical binding]; other site 364106001462 dimerization interface [polypeptide binding]; other site 364106001463 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 364106001464 tetramer interfaces [polypeptide binding]; other site 364106001465 binuclear metal-binding site [ion binding]; other site 364106001466 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 364106001467 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 364106001468 active site 364106001469 catalytic tetrad [active] 364106001470 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 364106001471 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 364106001472 TPP-binding site; other site 364106001473 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 364106001474 PYR/PP interface [polypeptide binding]; other site 364106001475 dimer interface [polypeptide binding]; other site 364106001476 TPP binding site [chemical binding]; other site 364106001477 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 364106001478 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 364106001479 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 364106001480 substrate binding pocket [chemical binding]; other site 364106001481 chain length determination region; other site 364106001482 substrate-Mg2+ binding site; other site 364106001483 catalytic residues [active] 364106001484 aspartate-rich region 1; other site 364106001485 active site lid residues [active] 364106001486 aspartate-rich region 2; other site 364106001487 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 364106001488 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 364106001489 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 364106001490 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 364106001491 Ligand Binding Site [chemical binding]; other site 364106001492 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 364106001493 active site residue [active] 364106001494 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 364106001495 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 364106001496 conserved cys residue [active] 364106001497 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 364106001498 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 364106001499 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 364106001500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 364106001501 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 364106001502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106001503 Major Facilitator Superfamily; Region: MFS_1; pfam07690 364106001504 putative substrate translocation pore; other site 364106001505 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 364106001506 UbiA prenyltransferase family; Region: UbiA; pfam01040 364106001507 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 364106001508 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 364106001509 Subunit I/III interface [polypeptide binding]; other site 364106001510 Subunit III/IV interface [polypeptide binding]; other site 364106001511 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 364106001512 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 364106001513 D-pathway; other site 364106001514 Putative ubiquinol binding site [chemical binding]; other site 364106001515 Low-spin heme (heme b) binding site [chemical binding]; other site 364106001516 Putative water exit pathway; other site 364106001517 Binuclear center (heme o3/CuB) [ion binding]; other site 364106001518 K-pathway; other site 364106001519 Putative proton exit pathway; other site 364106001520 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 364106001521 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 364106001522 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 364106001523 muropeptide transporter; Reviewed; Region: ampG; PRK11902 364106001524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106001525 putative substrate translocation pore; other site 364106001526 hypothetical protein; Provisional; Region: PRK11627 364106001527 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 364106001528 transcriptional regulator BolA; Provisional; Region: PRK11628 364106001529 trigger factor; Provisional; Region: tig; PRK01490 364106001530 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 364106001531 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 364106001532 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 364106001533 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 364106001534 oligomer interface [polypeptide binding]; other site 364106001535 active site residues [active] 364106001536 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 364106001537 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 364106001538 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106001539 Walker A motif; other site 364106001540 ATP binding site [chemical binding]; other site 364106001541 Walker B motif; other site 364106001542 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 364106001543 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 364106001544 Found in ATP-dependent protease La (LON); Region: LON; smart00464 364106001545 Found in ATP-dependent protease La (LON); Region: LON; smart00464 364106001546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106001547 Walker A motif; other site 364106001548 ATP binding site [chemical binding]; other site 364106001549 Walker B motif; other site 364106001550 arginine finger; other site 364106001551 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 364106001552 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 364106001553 IHF dimer interface [polypeptide binding]; other site 364106001554 IHF - DNA interface [nucleotide binding]; other site 364106001555 periplasmic folding chaperone; Provisional; Region: PRK10788 364106001556 SurA N-terminal domain; Region: SurA_N_3; cl07813 364106001557 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 364106001558 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 364106001559 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 364106001560 active site 364106001561 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 364106001562 Ligand Binding Site [chemical binding]; other site 364106001563 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 364106001564 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 364106001565 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 364106001566 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 364106001567 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 364106001568 active site 364106001569 motif I; other site 364106001570 motif II; other site 364106001571 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 364106001572 dimerization interface [polypeptide binding]; other site 364106001573 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 364106001574 putative DNA binding site [nucleotide binding]; other site 364106001575 putative Zn2+ binding site [ion binding]; other site 364106001576 AsnC family; Region: AsnC_trans_reg; pfam01037 364106001577 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 364106001578 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 364106001579 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 364106001580 Walker A/P-loop; other site 364106001581 ATP binding site [chemical binding]; other site 364106001582 Q-loop/lid; other site 364106001583 ABC transporter signature motif; other site 364106001584 Walker B; other site 364106001585 D-loop; other site 364106001586 H-loop/switch region; other site 364106001587 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 364106001588 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 364106001589 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 364106001590 Walker A/P-loop; other site 364106001591 ATP binding site [chemical binding]; other site 364106001592 Q-loop/lid; other site 364106001593 ABC transporter signature motif; other site 364106001594 Walker B; other site 364106001595 D-loop; other site 364106001596 H-loop/switch region; other site 364106001597 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 364106001598 Nitrogen regulatory protein P-II; Region: P-II; smart00938 364106001599 ammonium transporter; Provisional; Region: PRK10666 364106001600 acyl-CoA thioesterase II; Provisional; Region: PRK10526 364106001601 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 364106001602 active site 364106001603 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 364106001604 catalytic triad [active] 364106001605 dimer interface [polypeptide binding]; other site 364106001606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 364106001607 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 364106001608 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 364106001609 DNA binding site [nucleotide binding] 364106001610 active site 364106001611 Uncharacterized conserved protein [Function unknown]; Region: COG5507 364106001612 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 364106001613 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 364106001614 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 364106001615 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 364106001616 maltose O-acetyltransferase; Provisional; Region: PRK10092 364106001617 Maltose acetyltransferase; Region: Mac; pfam12464 364106001618 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 364106001619 trimer interface [polypeptide binding]; other site 364106001620 active site 364106001621 substrate binding site [chemical binding]; other site 364106001622 CoA binding site [chemical binding]; other site 364106001623 gene expression modulator; Provisional; Region: PRK10945 364106001624 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 364106001625 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 364106001626 Protein export membrane protein; Region: SecD_SecF; cl14618 364106001627 Protein export membrane protein; Region: SecD_SecF; cl14618 364106001628 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 364106001629 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 364106001630 HlyD family secretion protein; Region: HlyD_3; pfam13437 364106001631 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 364106001632 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 364106001633 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 364106001634 hypothetical protein; Provisional; Region: PRK11281 364106001635 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 364106001636 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 364106001637 Mechanosensitive ion channel; Region: MS_channel; pfam00924 364106001638 hypothetical protein; Provisional; Region: PRK11038 364106001639 primosomal replication protein N''; Provisional; Region: PRK10093 364106001640 hypothetical protein; Provisional; Region: PRK10527 364106001641 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 364106001642 active site 364106001643 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 364106001644 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106001645 Walker A motif; other site 364106001646 ATP binding site [chemical binding]; other site 364106001647 Walker B motif; other site 364106001648 DNA polymerase III subunit delta'; Validated; Region: PRK08485 364106001649 arginine finger; other site 364106001650 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 364106001651 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 364106001652 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 364106001653 hypothetical protein; Validated; Region: PRK00153 364106001654 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 364106001655 RecR protein; Region: RecR; pfam02132 364106001656 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 364106001657 putative active site [active] 364106001658 putative metal-binding site [ion binding]; other site 364106001659 tetramer interface [polypeptide binding]; other site 364106001660 heat shock protein 90; Provisional; Region: PRK05218 364106001661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106001662 ATP binding site [chemical binding]; other site 364106001663 Mg2+ binding site [ion binding]; other site 364106001664 G-X-G motif; other site 364106001665 adenylate kinase; Reviewed; Region: adk; PRK00279 364106001666 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 364106001667 AMP-binding site [chemical binding]; other site 364106001668 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 364106001669 ferrochelatase; Region: hemH; TIGR00109 364106001670 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 364106001671 C-terminal domain interface [polypeptide binding]; other site 364106001672 active site 364106001673 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 364106001674 active site 364106001675 N-terminal domain interface [polypeptide binding]; other site 364106001676 acetyl esterase; Provisional; Region: PRK10162 364106001677 inosine/guanosine kinase; Provisional; Region: PRK15074 364106001678 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 364106001679 putative cation:proton antiport protein; Provisional; Region: PRK10669 364106001680 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 364106001681 TrkA-N domain; Region: TrkA_N; pfam02254 364106001682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106001683 Major Facilitator Superfamily; Region: MFS_1; pfam07690 364106001684 putative substrate translocation pore; other site 364106001685 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 364106001686 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 364106001687 active site 364106001688 metal binding site [ion binding]; metal-binding site 364106001689 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 364106001690 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 364106001691 putative deacylase active site [active] 364106001692 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 364106001693 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 364106001694 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 364106001695 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 364106001696 non-specific DNA binding site [nucleotide binding]; other site 364106001697 salt bridge; other site 364106001698 sequence-specific DNA binding site [nucleotide binding]; other site 364106001699 copper exporting ATPase; Provisional; Region: copA; PRK10671 364106001700 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 364106001701 metal-binding site [ion binding] 364106001702 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 364106001703 metal-binding site [ion binding] 364106001704 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 364106001705 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 364106001706 motif II; other site 364106001707 glutaminase; Reviewed; Region: PRK12356 364106001708 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 364106001709 amino acid transporter; Region: 2A0306; TIGR00909 364106001710 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 364106001711 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 364106001712 DNA binding residues [nucleotide binding] 364106001713 dimer interface [polypeptide binding]; other site 364106001714 copper binding site [ion binding]; other site 364106001715 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 364106001716 YadA-like C-terminal region; Region: YadA; pfam03895 364106001717 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 364106001718 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 364106001719 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 364106001720 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 364106001721 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 364106001722 Walker A/P-loop; other site 364106001723 ATP binding site [chemical binding]; other site 364106001724 Q-loop/lid; other site 364106001725 ABC transporter signature motif; other site 364106001726 Walker B; other site 364106001727 D-loop; other site 364106001728 H-loop/switch region; other site 364106001729 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 364106001730 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 364106001731 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 364106001732 oxidoreductase; Provisional; Region: PRK08017 364106001733 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 364106001734 NADP binding site [chemical binding]; other site 364106001735 active site 364106001736 steroid binding site; other site 364106001737 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 364106001738 active site 364106001739 catalytic triad [active] 364106001740 oxyanion hole [active] 364106001741 switch loop; other site 364106001742 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 364106001743 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 364106001744 Walker A/P-loop; other site 364106001745 ATP binding site [chemical binding]; other site 364106001746 Q-loop/lid; other site 364106001747 ABC transporter signature motif; other site 364106001748 Walker B; other site 364106001749 D-loop; other site 364106001750 H-loop/switch region; other site 364106001751 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 364106001752 FtsX-like permease family; Region: FtsX; pfam02687 364106001753 FtsX-like permease family; Region: FtsX; pfam02687 364106001754 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 364106001755 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 364106001756 active site residue [active] 364106001757 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 364106001758 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106001759 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 364106001760 dimerization interface [polypeptide binding]; other site 364106001761 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 364106001762 ureidoglycolate hydrolase; Provisional; Region: PRK03606 364106001763 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 364106001764 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 364106001765 Bacterial transcriptional regulator; Region: IclR; pfam01614 364106001766 glyoxylate carboligase; Provisional; Region: PRK11269 364106001767 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 364106001768 PYR/PP interface [polypeptide binding]; other site 364106001769 dimer interface [polypeptide binding]; other site 364106001770 TPP binding site [chemical binding]; other site 364106001771 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 364106001772 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 364106001773 TPP-binding site [chemical binding]; other site 364106001774 hydroxypyruvate isomerase; Provisional; Region: PRK09997 364106001775 tartronate semialdehyde reductase; Provisional; Region: PRK15059 364106001776 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 364106001777 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 364106001778 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 364106001779 Na binding site [ion binding]; other site 364106001780 substrate binding site [chemical binding]; other site 364106001781 allantoinase; Provisional; Region: PRK08044 364106001782 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 364106001783 active site 364106001784 putative uracil/xanthine transporter; Provisional; Region: PRK11412 364106001785 glycerate kinase II; Provisional; Region: PRK09932 364106001786 putative allantoin catabolism protein; Region: ura-cupin; TIGR03214 364106001787 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 364106001788 Cupin domain; Region: Cupin_2; cl17218 364106001789 allantoate amidohydrolase; Region: AllC; TIGR03176 364106001790 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 364106001791 active site 364106001792 metal binding site [ion binding]; metal-binding site 364106001793 dimer interface [polypeptide binding]; other site 364106001794 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 364106001795 membrane protein FdrA; Validated; Region: PRK06091 364106001796 CoA binding domain; Region: CoA_binding; pfam02629 364106001797 CoA-ligase; Region: Ligase_CoA; pfam00549 364106001798 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 364106001799 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 364106001800 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 364106001801 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 364106001802 putative substrate binding site [chemical binding]; other site 364106001803 nucleotide binding site [chemical binding]; other site 364106001804 nucleotide binding site [chemical binding]; other site 364106001805 homodimer interface [polypeptide binding]; other site 364106001806 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 364106001807 ATP-grasp domain; Region: ATP-grasp; pfam02222 364106001808 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 364106001809 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 364106001810 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 364106001811 putative active site [active] 364106001812 putative metal binding site [ion binding]; other site 364106001813 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 364106001814 substrate binding site [chemical binding]; other site 364106001815 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 364106001816 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 364106001817 active site 364106001818 HIGH motif; other site 364106001819 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 364106001820 KMSKS motif; other site 364106001821 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 364106001822 tRNA binding surface [nucleotide binding]; other site 364106001823 anticodon binding site; other site 364106001824 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 364106001825 ribosome-associated protein; Provisional; Region: PRK11507 364106001826 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 364106001827 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 364106001828 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 364106001829 homodimer interface [polypeptide binding]; other site 364106001830 NADP binding site [chemical binding]; other site 364106001831 substrate binding site [chemical binding]; other site 364106001832 possible prophage 364106001833 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 364106001834 DNA binding site [nucleotide binding] 364106001835 active site 364106001836 Int/Topo IB signature motif; other site 364106001837 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 364106001838 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 364106001839 Methyltransferase domain; Region: Methyltransf_12; pfam08242 364106001840 S-adenosylmethionine binding site [chemical binding]; other site 364106001841 outer membrane protease; Reviewed; Region: PRK10993 364106001842 hypothetical protein; Provisional; Region: PRK09936 364106001843 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 364106001844 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 364106001845 TPR motif; other site 364106001846 binding surface 364106001847 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 364106001848 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 364106001849 active site 364106001850 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 364106001851 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 364106001852 sensor kinase CusS; Provisional; Region: PRK09835 364106001853 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 364106001854 dimerization interface [polypeptide binding]; other site 364106001855 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 364106001856 dimer interface [polypeptide binding]; other site 364106001857 phosphorylation site [posttranslational modification] 364106001858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106001859 ATP binding site [chemical binding]; other site 364106001860 Mg2+ binding site [ion binding]; other site 364106001861 G-X-G motif; other site 364106001862 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 364106001863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106001864 active site 364106001865 phosphorylation site [posttranslational modification] 364106001866 intermolecular recognition site; other site 364106001867 dimerization interface [polypeptide binding]; other site 364106001868 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 364106001869 DNA binding site [nucleotide binding] 364106001870 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 364106001871 periplasmic copper-binding protein; Provisional; Region: PRK09838 364106001872 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 364106001873 HlyD family secretion protein; Region: HlyD_3; pfam13437 364106001874 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 364106001875 phenylalanine transporter; Provisional; Region: PRK10249 364106001876 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 364106001877 Mechanosensitive ion channel; Region: MS_channel; pfam00924 364106001878 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 364106001879 dimer interface [polypeptide binding]; other site 364106001880 FMN binding site [chemical binding]; other site 364106001881 hypothetical protein; Provisional; Region: PRK10250 364106001882 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 364106001883 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 364106001884 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 364106001885 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 364106001886 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 364106001887 outer membrane receptor FepA; Provisional; Region: PRK13524 364106001888 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 364106001889 N-terminal plug; other site 364106001890 ligand-binding site [chemical binding]; other site 364106001891 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 364106001892 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 364106001893 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 364106001894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 364106001895 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 364106001896 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 364106001897 acyl-activating enzyme (AAE) consensus motif; other site 364106001898 AMP binding site [chemical binding]; other site 364106001899 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 364106001900 LPS O-antigen length regulator; Provisional; Region: PRK10381 364106001901 Chain length determinant protein; Region: Wzz; pfam02706 364106001902 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 364106001903 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 364106001904 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 364106001905 Walker A/P-loop; other site 364106001906 ATP binding site [chemical binding]; other site 364106001907 Q-loop/lid; other site 364106001908 ABC transporter signature motif; other site 364106001909 Walker B; other site 364106001910 D-loop; other site 364106001911 H-loop/switch region; other site 364106001912 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 364106001913 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 364106001914 ABC-ATPase subunit interface; other site 364106001915 dimer interface [polypeptide binding]; other site 364106001916 putative PBP binding regions; other site 364106001917 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 364106001918 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 364106001919 ABC-ATPase subunit interface; other site 364106001920 dimer interface [polypeptide binding]; other site 364106001921 putative PBP binding regions; other site 364106001922 enterobactin exporter EntS; Provisional; Region: PRK10489 364106001923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106001924 putative substrate translocation pore; other site 364106001925 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 364106001926 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 364106001927 siderophore binding site; other site 364106001928 isochorismate synthase EntC; Provisional; Region: PRK15016 364106001929 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 364106001930 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 364106001931 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 364106001932 acyl-activating enzyme (AAE) consensus motif; other site 364106001933 active site 364106001934 AMP binding site [chemical binding]; other site 364106001935 substrate binding site [chemical binding]; other site 364106001936 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 364106001937 hydrophobic substrate binding pocket; other site 364106001938 Isochorismatase family; Region: Isochorismatase; pfam00857 364106001939 active site 364106001940 conserved cis-peptide bond; other site 364106001941 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 364106001942 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 364106001943 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 364106001944 putative NAD(P) binding site [chemical binding]; other site 364106001945 active site 364106001946 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 364106001947 CoenzymeA binding site [chemical binding]; other site 364106001948 subunit interaction site [polypeptide binding]; other site 364106001949 PHB binding site; other site 364106001950 carbon starvation protein A; Provisional; Region: PRK15015 364106001951 Carbon starvation protein CstA; Region: CstA; pfam02554 364106001952 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 364106001953 Uncharacterized small protein [Function unknown]; Region: COG2879 364106001954 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 364106001955 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 364106001956 putative active site [active] 364106001957 metal binding site [ion binding]; metal-binding site 364106001958 methionine aminotransferase; Validated; Region: PRK09082 364106001959 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 364106001960 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106001961 homodimer interface [polypeptide binding]; other site 364106001962 catalytic residue [active] 364106001963 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 364106001964 ParB-like nuclease domain; Region: ParBc; pfam02195 364106001965 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 364106001966 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 364106001967 Active Sites [active] 364106001968 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 364106001969 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 364106001970 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106001971 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 364106001972 dimerization interface [polypeptide binding]; other site 364106001973 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 364106001974 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 364106001975 dimerization domain [polypeptide binding]; other site 364106001976 dimer interface [polypeptide binding]; other site 364106001977 catalytic residues [active] 364106001978 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 364106001979 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 364106001980 dimer interface [polypeptide binding]; other site 364106001981 decamer (pentamer of dimers) interface [polypeptide binding]; other site 364106001982 catalytic triad [active] 364106001983 peroxidatic and resolving cysteines [active] 364106001984 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 364106001985 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 364106001986 catalytic residue [active] 364106001987 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 364106001988 catalytic residues [active] 364106001989 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 364106001990 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 364106001991 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 364106001992 Ligand Binding Site [chemical binding]; other site 364106001993 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 364106001994 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 364106001995 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 364106001996 B1 nucleotide binding pocket [chemical binding]; other site 364106001997 B2 nucleotide binding pocket [chemical binding]; other site 364106001998 CAS motifs; other site 364106001999 active site 364106002000 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 364106002001 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 364106002002 transmembrane helices; other site 364106002003 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 364106002004 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 364106002005 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 364106002006 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 364106002007 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 364106002008 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 364106002009 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 364106002010 putative active site [active] 364106002011 (T/H)XGH motif; other site 364106002012 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 364106002013 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 364106002014 putative active site [active] 364106002015 heme pocket [chemical binding]; other site 364106002016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106002017 ATP binding site [chemical binding]; other site 364106002018 Mg2+ binding site [ion binding]; other site 364106002019 G-X-G motif; other site 364106002020 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 364106002021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106002022 active site 364106002023 phosphorylation site [posttranslational modification] 364106002024 intermolecular recognition site; other site 364106002025 dimerization interface [polypeptide binding]; other site 364106002026 Transcriptional regulator; Region: CitT; pfam12431 364106002027 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 364106002028 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 364106002029 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 364106002030 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 364106002031 DNA-binding site [nucleotide binding]; DNA binding site 364106002032 RNA-binding motif; other site 364106002033 chromosome condensation membrane protein; Provisional; Region: PRK14196 364106002034 Predicted amidohydrolase [General function prediction only]; Region: COG0388 364106002035 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 364106002036 putative active site [active] 364106002037 catalytic triad [active] 364106002038 putative dimer interface [polypeptide binding]; other site 364106002039 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 364106002040 lipoyl synthase; Provisional; Region: PRK05481 364106002041 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 364106002042 FeS/SAM binding site; other site 364106002043 lipoate-protein ligase B; Provisional; Region: PRK14342 364106002044 hypothetical protein; Provisional; Region: PRK04998 364106002045 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 364106002046 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 364106002047 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 364106002048 rare lipoprotein A; Provisional; Region: PRK10672 364106002049 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 364106002050 Sporulation related domain; Region: SPOR; pfam05036 364106002051 cell wall shape-determining protein; Provisional; Region: PRK10794 364106002052 penicillin-binding protein 2; Provisional; Region: PRK10795 364106002053 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 364106002054 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 364106002055 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 364106002056 ribosome-associated protein; Provisional; Region: PRK11538 364106002057 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 364106002058 catalytic core [active] 364106002059 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 364106002060 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 364106002061 active site 364106002062 (T/H)XGH motif; other site 364106002063 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 364106002064 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 364106002065 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 364106002066 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 364106002067 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 364106002068 HIGH motif; other site 364106002069 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 364106002070 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 364106002071 active site 364106002072 KMSKS motif; other site 364106002073 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 364106002074 tRNA binding surface [nucleotide binding]; other site 364106002075 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 364106002076 hypothetical protein; Provisional; Region: PRK11032 364106002077 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 364106002078 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 364106002079 active site 364106002080 tetramer interface [polypeptide binding]; other site 364106002081 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 364106002082 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 364106002083 Walker A/P-loop; other site 364106002084 ATP binding site [chemical binding]; other site 364106002085 Q-loop/lid; other site 364106002086 ABC transporter signature motif; other site 364106002087 Walker B; other site 364106002088 D-loop; other site 364106002089 H-loop/switch region; other site 364106002090 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 364106002091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106002092 dimer interface [polypeptide binding]; other site 364106002093 conserved gate region; other site 364106002094 putative PBP binding loops; other site 364106002095 ABC-ATPase subunit interface; other site 364106002096 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 364106002097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106002098 dimer interface [polypeptide binding]; other site 364106002099 conserved gate region; other site 364106002100 putative PBP binding loops; other site 364106002101 ABC-ATPase subunit interface; other site 364106002102 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 364106002103 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 364106002104 substrate binding pocket [chemical binding]; other site 364106002105 membrane-bound complex binding site; other site 364106002106 hinge residues; other site 364106002107 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 364106002108 Uncharacterized conserved protein [Function unknown]; Region: COG3391 364106002109 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 364106002110 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 364106002111 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 364106002112 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 364106002113 putative active site [active] 364106002114 catalytic triad [active] 364106002115 putative dimer interface [polypeptide binding]; other site 364106002116 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 364106002117 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 364106002118 Transporter associated domain; Region: CorC_HlyC; smart01091 364106002119 metal-binding heat shock protein; Provisional; Region: PRK00016 364106002120 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 364106002121 PhoH-like protein; Region: PhoH; pfam02562 364106002122 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 364106002123 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 364106002124 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 364106002125 FeS/SAM binding site; other site 364106002126 TRAM domain; Region: TRAM; pfam01938 364106002127 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 364106002128 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 364106002129 asparagine synthetase B; Provisional; Region: asnB; PRK09431 364106002130 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 364106002131 active site 364106002132 dimer interface [polypeptide binding]; other site 364106002133 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 364106002134 Ligand Binding Site [chemical binding]; other site 364106002135 Molecular Tunnel; other site 364106002136 UMP phosphatase; Provisional; Region: PRK10444 364106002137 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 364106002138 active site 364106002139 motif I; other site 364106002140 motif II; other site 364106002141 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 364106002142 MarR family; Region: MarR; pfam01047 364106002143 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 364106002144 ROK family; Region: ROK; pfam00480 364106002145 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 364106002146 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 364106002147 active site 364106002148 dimer interface [polypeptide binding]; other site 364106002149 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 364106002150 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 364106002151 active site 364106002152 trimer interface [polypeptide binding]; other site 364106002153 allosteric site; other site 364106002154 active site lid [active] 364106002155 hexamer (dimer of trimers) interface [polypeptide binding]; other site 364106002156 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 364106002157 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 364106002158 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 364106002159 active site turn [active] 364106002160 phosphorylation site [posttranslational modification] 364106002161 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 364106002162 HPr interaction site; other site 364106002163 glycerol kinase (GK) interaction site [polypeptide binding]; other site 364106002164 active site 364106002165 phosphorylation site [posttranslational modification] 364106002166 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 364106002167 transmembrane helices; other site 364106002168 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 364106002169 Domain of unknown function (DUF386); Region: DUF386; cl01047 364106002170 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 364106002171 BNR repeat-like domain; Region: BNR_2; pfam13088 364106002172 dihydrodipicolinate synthase; Region: dapA; TIGR00674 364106002173 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 364106002174 inhibitor site; inhibition site 364106002175 active site 364106002176 dimer interface [polypeptide binding]; other site 364106002177 catalytic residue [active] 364106002178 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 364106002179 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 364106002180 putative active site [active] 364106002181 metal binding site [ion binding]; metal-binding site 364106002182 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 364106002183 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 364106002184 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 364106002185 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 364106002186 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 364106002187 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 364106002188 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 364106002189 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 364106002190 active site 364106002191 HIGH motif; other site 364106002192 nucleotide binding site [chemical binding]; other site 364106002193 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 364106002194 KMSKS motif; other site 364106002195 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 364106002196 outer membrane porin, OprD family; Region: OprD; pfam03573 364106002197 YbfN-like lipoprotein; Region: YbfN; pfam13982 364106002198 ferric uptake regulator; Provisional; Region: fur; PRK09462 364106002199 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 364106002200 metal binding site 2 [ion binding]; metal-binding site 364106002201 putative DNA binding helix; other site 364106002202 metal binding site 1 [ion binding]; metal-binding site 364106002203 dimer interface [polypeptide binding]; other site 364106002204 structural Zn2+ binding site [ion binding]; other site 364106002205 flavodoxin FldA; Validated; Region: PRK09267 364106002206 LexA regulated protein; Provisional; Region: PRK11675 364106002207 acyl-CoA esterase; Provisional; Region: PRK10673 364106002208 PGAP1-like protein; Region: PGAP1; pfam07819 364106002209 replication initiation regulator SeqA; Provisional; Region: PRK11187 364106002210 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 364106002211 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 364106002212 active site 364106002213 substrate binding site [chemical binding]; other site 364106002214 metal binding site [ion binding]; metal-binding site 364106002215 putrescine transporter; Provisional; Region: potE; PRK10655 364106002216 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 364106002217 ornithine decarboxylase; Provisional; Region: PRK13578 364106002218 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 364106002219 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 364106002220 homodimer interface [polypeptide binding]; other site 364106002221 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106002222 catalytic residue [active] 364106002223 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 364106002224 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 364106002225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106002226 active site 364106002227 phosphorylation site [posttranslational modification] 364106002228 intermolecular recognition site; other site 364106002229 dimerization interface [polypeptide binding]; other site 364106002230 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 364106002231 DNA binding site [nucleotide binding] 364106002232 sensor protein KdpD; Provisional; Region: PRK10490 364106002233 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 364106002234 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 364106002235 Ligand Binding Site [chemical binding]; other site 364106002236 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 364106002237 GAF domain; Region: GAF_3; pfam13492 364106002238 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 364106002239 dimer interface [polypeptide binding]; other site 364106002240 phosphorylation site [posttranslational modification] 364106002241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106002242 ATP binding site [chemical binding]; other site 364106002243 Mg2+ binding site [ion binding]; other site 364106002244 G-X-G motif; other site 364106002245 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 364106002246 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 364106002247 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 364106002248 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 364106002249 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 364106002250 hypothetical protein; Provisional; Region: PRK10167 364106002251 Uncharacterized conserved protein [Function unknown]; Region: COG3272 364106002252 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 364106002253 DNA photolyase; Region: DNA_photolyase; pfam00875 364106002254 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 364106002255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106002256 putative substrate translocation pore; other site 364106002257 POT family; Region: PTR2; pfam00854 364106002258 Uncharacterized conserved protein [Function unknown]; Region: COG0327 364106002259 metal-binding protein; Provisional; Region: PRK10799 364106002260 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 364106002261 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 364106002262 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 364106002263 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 364106002264 putative active site [active] 364106002265 endonuclease VIII; Provisional; Region: PRK10445 364106002266 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 364106002267 DNA binding site [nucleotide binding] 364106002268 catalytic residue [active] 364106002269 putative catalytic residues [active] 364106002270 H2TH interface [polypeptide binding]; other site 364106002271 intercalation triad [nucleotide binding]; other site 364106002272 substrate specificity determining residue; other site 364106002273 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 364106002274 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 364106002275 Putative ammonia monooxygenase; Region: AmoA; pfam05145 364106002276 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 364106002277 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 364106002278 Fimbrial protein; Region: Fimbrial; pfam00419 364106002279 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 364106002280 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 364106002281 dimer interface [polypeptide binding]; other site 364106002282 active site 364106002283 citrylCoA binding site [chemical binding]; other site 364106002284 NADH binding [chemical binding]; other site 364106002285 cationic pore residues; other site 364106002286 oxalacetate/citrate binding site [chemical binding]; other site 364106002287 coenzyme A binding site [chemical binding]; other site 364106002288 catalytic triad [active] 364106002289 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 364106002290 Iron-sulfur protein interface; other site 364106002291 proximal quinone binding site [chemical binding]; other site 364106002292 SdhD (CybS) interface [polypeptide binding]; other site 364106002293 proximal heme binding site [chemical binding]; other site 364106002294 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 364106002295 SdhC subunit interface [polypeptide binding]; other site 364106002296 proximal heme binding site [chemical binding]; other site 364106002297 cardiolipin binding site; other site 364106002298 Iron-sulfur protein interface; other site 364106002299 proximal quinone binding site [chemical binding]; other site 364106002300 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 364106002301 L-aspartate oxidase; Provisional; Region: PRK06175 364106002302 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 364106002303 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 364106002304 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 364106002305 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 364106002306 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 364106002307 TPP-binding site [chemical binding]; other site 364106002308 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 364106002309 dimer interface [polypeptide binding]; other site 364106002310 PYR/PP interface [polypeptide binding]; other site 364106002311 TPP binding site [chemical binding]; other site 364106002312 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 364106002313 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 364106002314 E3 interaction surface; other site 364106002315 lipoyl attachment site [posttranslational modification]; other site 364106002316 e3 binding domain; Region: E3_binding; pfam02817 364106002317 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 364106002318 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 364106002319 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 364106002320 CoA-ligase; Region: Ligase_CoA; pfam00549 364106002321 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 364106002322 CoA binding domain; Region: CoA_binding; smart00881 364106002323 CoA-ligase; Region: Ligase_CoA; pfam00549 364106002324 TPR repeat; Region: TPR_11; pfam13414 364106002325 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 364106002326 binding surface 364106002327 TPR motif; other site 364106002328 Tetratricopeptide repeat; Region: TPR_12; pfam13424 364106002329 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 364106002330 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 364106002331 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 364106002332 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 364106002333 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 364106002334 hypothetical protein; Provisional; Region: PRK10588 364106002335 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 364106002336 active site 364106002337 colicin uptake protein TolQ; Provisional; Region: PRK10801 364106002338 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 364106002339 colicin uptake protein TolR; Provisional; Region: PRK11024 364106002340 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 364106002341 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 364106002342 TolA C-terminal; Region: TolA; pfam06519 364106002343 translocation protein TolB; Provisional; Region: tolB; PRK03629 364106002344 TolB amino-terminal domain; Region: TolB_N; pfam04052 364106002345 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 364106002346 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 364106002347 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 364106002348 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 364106002349 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 364106002350 ligand binding site [chemical binding]; other site 364106002351 tol-pal system protein YbgF; Provisional; Region: PRK10803 364106002352 Tetratricopeptide repeat; Region: TPR_6; pfam13174 364106002353 Tetratricopeptide repeat; Region: TPR_6; pfam13174 364106002354 quinolinate synthetase; Provisional; Region: PRK09375 364106002355 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 364106002356 zinc transporter ZitB; Provisional; Region: PRK03557 364106002357 YbgS-like protein; Region: YbgS; pfam13985 364106002358 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 364106002359 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 364106002360 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 364106002361 catalytic core [active] 364106002362 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 364106002363 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 364106002364 active site 364106002365 catalytic residues [active] 364106002366 galactokinase; Provisional; Region: PRK05101 364106002367 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 364106002368 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 364106002369 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 364106002370 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 364106002371 dimer interface [polypeptide binding]; other site 364106002372 active site 364106002373 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 364106002374 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 364106002375 NAD binding site [chemical binding]; other site 364106002376 homodimer interface [polypeptide binding]; other site 364106002377 active site 364106002378 substrate binding site [chemical binding]; other site 364106002379 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 364106002380 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 364106002381 Walker A/P-loop; other site 364106002382 ATP binding site [chemical binding]; other site 364106002383 Q-loop/lid; other site 364106002384 ABC transporter signature motif; other site 364106002385 Walker B; other site 364106002386 D-loop; other site 364106002387 H-loop/switch region; other site 364106002388 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 364106002389 Walker A/P-loop; other site 364106002390 ATP binding site [chemical binding]; other site 364106002391 Q-loop/lid; other site 364106002392 ABC transporter signature motif; other site 364106002393 Walker B; other site 364106002394 D-loop; other site 364106002395 H-loop/switch region; other site 364106002396 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 364106002397 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 364106002398 molybdenum-pterin binding domain; Region: Mop; TIGR00638 364106002399 TOBE domain; Region: TOBE; pfam03459 364106002400 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 364106002401 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 364106002402 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 364106002403 substrate binding pocket [chemical binding]; other site 364106002404 membrane-bound complex binding site; other site 364106002405 hinge residues; other site 364106002406 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 364106002407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106002408 dimer interface [polypeptide binding]; other site 364106002409 conserved gate region; other site 364106002410 putative PBP binding loops; other site 364106002411 ABC-ATPase subunit interface; other site 364106002412 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 364106002413 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 364106002414 Walker A/P-loop; other site 364106002415 ATP binding site [chemical binding]; other site 364106002416 Q-loop/lid; other site 364106002417 ABC transporter signature motif; other site 364106002418 Walker B; other site 364106002419 D-loop; other site 364106002420 H-loop/switch region; other site 364106002421 molybdenum-pterin binding domain; Region: Mop; TIGR00638 364106002422 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 364106002423 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 364106002424 motif II; other site 364106002425 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 364106002426 6-phosphogluconolactonase; Provisional; Region: PRK11028 364106002427 Transcriptional regulator [Transcription]; Region: LysR; COG0583 364106002428 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106002429 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 364106002430 putative dimerization interface [polypeptide binding]; other site 364106002431 PrpF protein; Region: PrpF; pfam04303 364106002432 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 364106002433 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 364106002434 transmembrane helices; other site 364106002435 putative hydratase; Provisional; Region: PRK11413 364106002436 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 364106002437 substrate binding site [chemical binding]; other site 364106002438 ligand binding site [chemical binding]; other site 364106002439 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 364106002440 substrate binding site [chemical binding]; other site 364106002441 acyl-CoA thioesterase; Provisional; Region: PRK10531 364106002442 putative pectinesterase; Region: PLN02432; cl01911 364106002443 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 364106002444 substrate binding site [chemical binding]; other site 364106002445 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 364106002446 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 364106002447 inhibitor-cofactor binding pocket; inhibition site 364106002448 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106002449 catalytic residue [active] 364106002450 biotin synthase; Provisional; Region: PRK15108 364106002451 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 364106002452 FeS/SAM binding site; other site 364106002453 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 364106002454 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 364106002455 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 364106002456 substrate-cofactor binding pocket; other site 364106002457 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106002458 catalytic residue [active] 364106002459 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 364106002460 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106002461 S-adenosylmethionine binding site [chemical binding]; other site 364106002462 AAA domain; Region: AAA_26; pfam13500 364106002463 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 364106002464 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 364106002465 ADP binding site [chemical binding]; other site 364106002466 excinuclease ABC subunit B; Provisional; Region: PRK05298 364106002467 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 364106002468 ATP binding site [chemical binding]; other site 364106002469 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 364106002470 nucleotide binding region [chemical binding]; other site 364106002471 ATP-binding site [chemical binding]; other site 364106002472 Ultra-violet resistance protein B; Region: UvrB; pfam12344 364106002473 UvrB/uvrC motif; Region: UVR; pfam02151 364106002474 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 364106002475 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 364106002476 putative substrate binding pocket [chemical binding]; other site 364106002477 dimer interface [polypeptide binding]; other site 364106002478 phosphate binding site [ion binding]; other site 364106002479 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 364106002480 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 364106002481 FeS/SAM binding site; other site 364106002482 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 364106002483 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 364106002484 MPT binding site; other site 364106002485 trimer interface [polypeptide binding]; other site 364106002486 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 364106002487 trimer interface [polypeptide binding]; other site 364106002488 dimer interface [polypeptide binding]; other site 364106002489 putative active site [active] 364106002490 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 364106002491 MoaE interaction surface [polypeptide binding]; other site 364106002492 MoeB interaction surface [polypeptide binding]; other site 364106002493 thiocarboxylated glycine; other site 364106002494 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 364106002495 MoaE homodimer interface [polypeptide binding]; other site 364106002496 MoaD interaction [polypeptide binding]; other site 364106002497 active site residues [active] 364106002498 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 364106002499 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 364106002500 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 364106002501 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 364106002502 Predicted integral membrane protein [Function unknown]; Region: COG0392 364106002503 cardiolipin synthase 2; Provisional; Region: PRK11263 364106002504 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 364106002505 putative active site [active] 364106002506 catalytic site [active] 364106002507 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 364106002508 putative active site [active] 364106002509 catalytic site [active] 364106002510 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 364106002511 putative catalytic site [active] 364106002512 putative metal binding site [ion binding]; other site 364106002513 putative phosphate binding site [ion binding]; other site 364106002514 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 364106002515 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 364106002516 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 364106002517 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 364106002518 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 364106002519 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 364106002520 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 364106002521 Walker A/P-loop; other site 364106002522 ATP binding site [chemical binding]; other site 364106002523 Q-loop/lid; other site 364106002524 ABC transporter signature motif; other site 364106002525 Walker B; other site 364106002526 D-loop; other site 364106002527 H-loop/switch region; other site 364106002528 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 364106002529 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 364106002530 Walker A/P-loop; other site 364106002531 ATP binding site [chemical binding]; other site 364106002532 Q-loop/lid; other site 364106002533 ABC transporter signature motif; other site 364106002534 Walker B; other site 364106002535 D-loop; other site 364106002536 H-loop/switch region; other site 364106002537 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 364106002538 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 364106002539 HlyD family secretion protein; Region: HlyD_3; pfam13437 364106002540 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 364106002541 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 364106002542 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 364106002543 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 364106002544 ATP binding site [chemical binding]; other site 364106002545 Mg++ binding site [ion binding]; other site 364106002546 motif III; other site 364106002547 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 364106002548 nucleotide binding region [chemical binding]; other site 364106002549 ATP-binding site [chemical binding]; other site 364106002550 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 364106002551 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 364106002552 DEAD_2; Region: DEAD_2; pfam06733 364106002553 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 364106002554 glycosyl transferase family protein; Provisional; Region: PRK08136 364106002555 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 364106002556 putative dehydrogenase; Provisional; Region: PRK10098 364106002557 hypothetical protein; Provisional; Region: PRK10259 364106002558 hypothetical protein; Provisional; Region: PRK11019 364106002559 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 364106002560 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 364106002561 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 364106002562 N-terminal plug; other site 364106002563 ligand-binding site [chemical binding]; other site 364106002564 hypothetical protein; Provisional; Region: PRK10259 364106002565 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 364106002566 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 364106002567 putative mechanosensitive channel protein; Provisional; Region: PRK11465 364106002568 Mechanosensitive ion channel; Region: MS_channel; pfam00924 364106002569 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 364106002570 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 364106002571 Walker A/P-loop; other site 364106002572 ATP binding site [chemical binding]; other site 364106002573 Q-loop/lid; other site 364106002574 ABC transporter signature motif; other site 364106002575 Walker B; other site 364106002576 D-loop; other site 364106002577 H-loop/switch region; other site 364106002578 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 364106002579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106002580 dimer interface [polypeptide binding]; other site 364106002581 conserved gate region; other site 364106002582 putative PBP binding loops; other site 364106002583 ABC-ATPase subunit interface; other site 364106002584 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 364106002585 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 364106002586 substrate binding pocket [chemical binding]; other site 364106002587 membrane-bound complex binding site; other site 364106002588 hinge residues; other site 364106002589 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 364106002590 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 364106002591 dimerization interface [polypeptide binding]; other site 364106002592 DPS ferroxidase diiron center [ion binding]; other site 364106002593 ion pore; other site 364106002594 threonine and homoserine efflux system; Provisional; Region: PRK10532 364106002595 EamA-like transporter family; Region: EamA; pfam00892 364106002596 outer membrane protein X; Provisional; Region: ompX; PRK09408 364106002597 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 364106002598 Sulfatase; Region: Sulfatase; pfam00884 364106002599 manganese transport regulator MntR; Provisional; Region: PRK11050 364106002600 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 364106002601 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 364106002602 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 364106002603 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 364106002604 transmembrane helices; other site 364106002605 L,D-transpeptidase; Provisional; Region: PRK10260 364106002606 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 364106002607 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 364106002608 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 364106002609 Walker A/P-loop; other site 364106002610 ATP binding site [chemical binding]; other site 364106002611 Q-loop/lid; other site 364106002612 ABC transporter signature motif; other site 364106002613 Walker B; other site 364106002614 D-loop; other site 364106002615 H-loop/switch region; other site 364106002616 ABC transporter; Region: ABC_tran_2; pfam12848 364106002617 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 364106002618 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 364106002619 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 364106002620 active site 364106002621 motif I; other site 364106002622 motif II; other site 364106002623 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 364106002624 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 364106002625 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 364106002626 dimer interface [polypeptide binding]; other site 364106002627 active site 364106002628 glycine loop; other site 364106002629 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 364106002630 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 364106002631 active site 364106002632 intersubunit interactions; other site 364106002633 catalytic residue [active] 364106002634 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 364106002635 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 364106002636 ATP binding site [chemical binding]; other site 364106002637 substrate interface [chemical binding]; other site 364106002638 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 364106002639 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 364106002640 dimer interface [polypeptide binding]; other site 364106002641 putative functional site; other site 364106002642 putative MPT binding site; other site 364106002643 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 364106002644 catalytic nucleophile [active] 364106002645 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 364106002646 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 364106002647 Walker A/P-loop; other site 364106002648 ATP binding site [chemical binding]; other site 364106002649 Q-loop/lid; other site 364106002650 ABC transporter signature motif; other site 364106002651 Walker B; other site 364106002652 D-loop; other site 364106002653 H-loop/switch region; other site 364106002654 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 364106002655 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 364106002656 Walker A/P-loop; other site 364106002657 ATP binding site [chemical binding]; other site 364106002658 Q-loop/lid; other site 364106002659 ABC transporter signature motif; other site 364106002660 Walker B; other site 364106002661 D-loop; other site 364106002662 H-loop/switch region; other site 364106002663 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 364106002664 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 364106002665 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 364106002666 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 364106002667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106002668 dimer interface [polypeptide binding]; other site 364106002669 conserved gate region; other site 364106002670 putative PBP binding loops; other site 364106002671 ABC-ATPase subunit interface; other site 364106002672 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 364106002673 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 364106002674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106002675 dimer interface [polypeptide binding]; other site 364106002676 conserved gate region; other site 364106002677 putative PBP binding loops; other site 364106002678 ABC-ATPase subunit interface; other site 364106002679 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 364106002680 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 364106002681 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 364106002682 metal binding site [ion binding]; metal-binding site 364106002683 active site 364106002684 I-site; other site 364106002685 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 364106002686 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 364106002687 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 364106002688 FeS/SAM binding site; other site 364106002689 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 364106002690 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 364106002691 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 364106002692 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 364106002693 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 364106002694 putative C-terminal domain interface [polypeptide binding]; other site 364106002695 putative GSH binding site (G-site) [chemical binding]; other site 364106002696 putative dimer interface [polypeptide binding]; other site 364106002697 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 364106002698 N-terminal domain interface [polypeptide binding]; other site 364106002699 dimer interface [polypeptide binding]; other site 364106002700 substrate binding pocket (H-site) [chemical binding]; other site 364106002701 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 364106002702 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 364106002703 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 364106002704 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 364106002705 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 364106002706 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 364106002707 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 364106002708 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 364106002709 active site 364106002710 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 364106002711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106002712 putative substrate translocation pore; other site 364106002713 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 364106002714 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 364106002715 active site 364106002716 motif I; other site 364106002717 motif II; other site 364106002718 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 364106002719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106002720 putative substrate translocation pore; other site 364106002721 Major Facilitator Superfamily; Region: MFS_1; pfam07690 364106002722 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 364106002723 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 364106002724 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 364106002725 putative transporter; Provisional; Region: PRK04972 364106002726 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 364106002727 TrkA-C domain; Region: TrkA_C; pfam02080 364106002728 TrkA-C domain; Region: TrkA_C; pfam02080 364106002729 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 364106002730 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 364106002731 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 364106002732 GSH binding site [chemical binding]; other site 364106002733 catalytic residues [active] 364106002734 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 364106002735 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 364106002736 dimer interface [polypeptide binding]; other site 364106002737 FMN binding site [chemical binding]; other site 364106002738 NADPH bind site [chemical binding]; other site 364106002739 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 364106002740 RimK-like ATP-grasp domain; Region: RimK; pfam08443 364106002741 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 364106002742 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 364106002743 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 364106002744 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 364106002745 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 364106002746 Walker A/P-loop; other site 364106002747 ATP binding site [chemical binding]; other site 364106002748 Q-loop/lid; other site 364106002749 ABC transporter signature motif; other site 364106002750 Walker B; other site 364106002751 D-loop; other site 364106002752 H-loop/switch region; other site 364106002753 TOBE domain; Region: TOBE_2; pfam08402 364106002754 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 364106002755 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106002756 dimer interface [polypeptide binding]; other site 364106002757 conserved gate region; other site 364106002758 putative PBP binding loops; other site 364106002759 ABC-ATPase subunit interface; other site 364106002760 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 364106002761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106002762 dimer interface [polypeptide binding]; other site 364106002763 conserved gate region; other site 364106002764 putative PBP binding loops; other site 364106002765 ABC-ATPase subunit interface; other site 364106002766 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 364106002767 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 364106002768 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106002769 S-adenosylmethionine binding site [chemical binding]; other site 364106002770 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 364106002771 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 364106002772 substrate binding pocket [chemical binding]; other site 364106002773 membrane-bound complex binding site; other site 364106002774 hinge residues; other site 364106002775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106002776 dimer interface [polypeptide binding]; other site 364106002777 conserved gate region; other site 364106002778 putative PBP binding loops; other site 364106002779 ABC-ATPase subunit interface; other site 364106002780 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 364106002781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106002782 dimer interface [polypeptide binding]; other site 364106002783 conserved gate region; other site 364106002784 putative PBP binding loops; other site 364106002785 ABC-ATPase subunit interface; other site 364106002786 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 364106002787 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 364106002788 substrate binding pocket [chemical binding]; other site 364106002789 membrane-bound complex binding site; other site 364106002790 hinge residues; other site 364106002791 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 364106002792 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 364106002793 Walker A/P-loop; other site 364106002794 ATP binding site [chemical binding]; other site 364106002795 Q-loop/lid; other site 364106002796 ABC transporter signature motif; other site 364106002797 Walker B; other site 364106002798 D-loop; other site 364106002799 H-loop/switch region; other site 364106002800 putative lipoprotein; Provisional; Region: PRK10533 364106002801 hypothetical protein; Provisional; Region: PRK02877 364106002802 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 364106002803 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 364106002804 amidase catalytic site [active] 364106002805 Zn binding residues [ion binding]; other site 364106002806 substrate binding site [chemical binding]; other site 364106002807 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 364106002808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 364106002809 NAD(P) binding site [chemical binding]; other site 364106002810 active site 364106002811 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 364106002812 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 364106002813 putative NAD(P) binding site [chemical binding]; other site 364106002814 putative active site [active] 364106002815 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 364106002816 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 364106002817 tetramer interface [polypeptide binding]; other site 364106002818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106002819 catalytic residue [active] 364106002820 pyruvate dehydrogenase; Provisional; Region: PRK09124 364106002821 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 364106002822 PYR/PP interface [polypeptide binding]; other site 364106002823 dimer interface [polypeptide binding]; other site 364106002824 tetramer interface [polypeptide binding]; other site 364106002825 TPP binding site [chemical binding]; other site 364106002826 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 364106002827 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 364106002828 TPP-binding site [chemical binding]; other site 364106002829 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 364106002830 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 364106002831 FAD binding pocket [chemical binding]; other site 364106002832 FAD binding motif [chemical binding]; other site 364106002833 phosphate binding motif [ion binding]; other site 364106002834 beta-alpha-beta structure motif; other site 364106002835 NAD binding pocket [chemical binding]; other site 364106002836 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 364106002837 catalytic loop [active] 364106002838 iron binding site [ion binding]; other site 364106002839 hybrid cluster protein; Provisional; Region: PRK05290 364106002840 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 364106002841 ACS interaction site; other site 364106002842 CODH interaction site; other site 364106002843 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 364106002844 hybrid metal cluster; other site 364106002845 Predicted membrane protein [Function unknown]; Region: COG2431 364106002846 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 364106002847 amphipathic channel; other site 364106002848 Asn-Pro-Ala signature motifs; other site 364106002849 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 364106002850 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 364106002851 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 364106002852 putative active site [active] 364106002853 putative metal-binding site [ion binding]; other site 364106002854 Protein of unknown function (DUF535); Region: DUF535; pfam04393 364106002855 macrolide transporter subunit MacA; Provisional; Region: PRK11578 364106002856 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 364106002857 HlyD family secretion protein; Region: HlyD_3; pfam13437 364106002858 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 364106002859 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 364106002860 Walker A/P-loop; other site 364106002861 ATP binding site [chemical binding]; other site 364106002862 Q-loop/lid; other site 364106002863 ABC transporter signature motif; other site 364106002864 Walker B; other site 364106002865 D-loop; other site 364106002866 H-loop/switch region; other site 364106002867 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 364106002868 FtsX-like permease family; Region: FtsX; pfam02687 364106002869 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 364106002870 DNA-binding site [nucleotide binding]; DNA binding site 364106002871 RNA-binding motif; other site 364106002872 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 364106002873 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 364106002874 Clp amino terminal domain; Region: Clp_N; pfam02861 364106002875 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106002876 Walker A motif; other site 364106002877 ATP binding site [chemical binding]; other site 364106002878 Walker B motif; other site 364106002879 arginine finger; other site 364106002880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106002881 Walker A motif; other site 364106002882 ATP binding site [chemical binding]; other site 364106002883 Walker B motif; other site 364106002884 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 364106002885 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-F; cd09718 364106002886 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 364106002887 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 364106002888 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09735 364106002889 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cl12127 364106002890 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736 364106002891 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 364106002892 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739 364106002893 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 364106002894 rRNA binding site [nucleotide binding]; other site 364106002895 predicted 30S ribosome binding site; other site 364106002896 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 364106002897 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 364106002898 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 364106002899 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 364106002900 Walker A/P-loop; other site 364106002901 ATP binding site [chemical binding]; other site 364106002902 Q-loop/lid; other site 364106002903 ABC transporter signature motif; other site 364106002904 Walker B; other site 364106002905 D-loop; other site 364106002906 H-loop/switch region; other site 364106002907 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 364106002908 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 364106002909 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 364106002910 Walker A/P-loop; other site 364106002911 ATP binding site [chemical binding]; other site 364106002912 Q-loop/lid; other site 364106002913 ABC transporter signature motif; other site 364106002914 Walker B; other site 364106002915 D-loop; other site 364106002916 H-loop/switch region; other site 364106002917 thioredoxin reductase; Provisional; Region: PRK10262 364106002918 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 364106002919 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 364106002920 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 364106002921 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 364106002922 putative DNA binding site [nucleotide binding]; other site 364106002923 putative Zn2+ binding site [ion binding]; other site 364106002924 AsnC family; Region: AsnC_trans_reg; pfam01037 364106002925 DNA translocase FtsK; Provisional; Region: PRK10263 364106002926 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 364106002927 DNA translocase FtsK; Provisional; Region: PRK10263 364106002928 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 364106002929 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 364106002930 periplasmic chaperone LolA; Region: lolA; TIGR00547 364106002931 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 364106002932 recombination factor protein RarA; Reviewed; Region: PRK13342 364106002933 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106002934 Walker A motif; other site 364106002935 ATP binding site [chemical binding]; other site 364106002936 Walker B motif; other site 364106002937 arginine finger; other site 364106002938 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 364106002939 seryl-tRNA synthetase; Provisional; Region: PRK05431 364106002940 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 364106002941 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 364106002942 dimer interface [polypeptide binding]; other site 364106002943 active site 364106002944 motif 1; other site 364106002945 motif 2; other site 364106002946 motif 3; other site 364106002947 Hok/gef family; Region: HOK_GEF; pfam01848 364106002948 possible prophage 364106002949 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 364106002950 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 364106002951 tail protein; Provisional; Region: D; PHA02561 364106002952 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 364106002953 Phage tail tube protein FII; Region: Phage_tube; cl01390 364106002954 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 364106002955 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 364106002956 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 364106002957 Phage protein U [General function prediction only]; Region: COG3499 364106002958 multiple promoter invertase; Provisional; Region: mpi; PRK13413 364106002959 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 364106002960 catalytic residues [active] 364106002961 catalytic nucleophile [active] 364106002962 Presynaptic Site I dimer interface [polypeptide binding]; other site 364106002963 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 364106002964 Synaptic Flat tetramer interface [polypeptide binding]; other site 364106002965 Synaptic Site I dimer interface [polypeptide binding]; other site 364106002966 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 364106002967 DNA-binding interface [nucleotide binding]; DNA binding site 364106002968 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 364106002969 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 364106002970 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 364106002971 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 364106002972 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 364106002973 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 364106002974 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 364106002975 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 364106002976 Baseplate J-like protein; Region: Baseplate_J; cl01294 364106002977 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 364106002978 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 364106002979 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 364106002980 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 364106002981 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 364106002982 Protein of unknown function (DUF2570); Region: DUF2570; pfam10828 364106002983 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 364106002984 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 364106002985 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 364106002986 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 364106002987 terminase endonuclease subunit; Provisional; Region: M; PHA02537 364106002988 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 364106002989 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 364106002990 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 364106002991 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 364106002992 terminase ATPase subunit; Provisional; Region: P; PHA02535 364106002993 Phage-related protein [Function unknown]; Region: COG4695; cl01923 364106002994 Phage portal protein; Region: Phage_portal; pfam04860 364106002995 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 364106002996 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 364106002997 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 364106002998 Mg binding site [ion binding]; other site 364106002999 nucleotide binding site [chemical binding]; other site 364106003000 putative protofilament interface [polypeptide binding]; other site 364106003001 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 364106003002 SPFH domain / Band 7 family; Region: Band_7; pfam01145 364106003003 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 364106003004 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 364106003005 Transcriptional regulators [Transcription]; Region: MarR; COG1846 364106003006 MarR family; Region: MarR_2; pfam12802 364106003007 Regulatory phage protein cox; Region: Phage_Cox; pfam10743 364106003008 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 364106003009 non-specific DNA binding site [nucleotide binding]; other site 364106003010 salt bridge; other site 364106003011 sequence-specific DNA binding site [nucleotide binding]; other site 364106003012 integrase; Provisional; Region: int; PHA02601 364106003013 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 364106003014 active site 364106003015 DNA binding site [nucleotide binding] 364106003016 Int/Topo IB signature motif; other site 364106003017 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 364106003018 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 364106003019 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 364106003020 putative [Fe4-S4] binding site [ion binding]; other site 364106003021 putative molybdopterin cofactor binding site [chemical binding]; other site 364106003022 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 364106003023 putative molybdopterin cofactor binding site; other site 364106003024 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 364106003025 4Fe-4S binding domain; Region: Fer4; pfam00037 364106003026 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 364106003027 Isochorismatase family; Region: Isochorismatase; pfam00857 364106003028 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 364106003029 catalytic triad [active] 364106003030 dimer interface [polypeptide binding]; other site 364106003031 conserved cis-peptide bond; other site 364106003032 putative MFS family transporter protein; Provisional; Region: PRK03633 364106003033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106003034 putative substrate translocation pore; other site 364106003035 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 364106003036 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 364106003037 FeS/SAM binding site; other site 364106003038 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 364106003039 Pyruvate formate lyase 1; Region: PFL1; cd01678 364106003040 coenzyme A binding site [chemical binding]; other site 364106003041 active site 364106003042 catalytic residues [active] 364106003043 glycine loop; other site 364106003044 formate transporter; Provisional; Region: PRK10805 364106003045 uncharacterized domain; Region: TIGR00702 364106003046 YcaO-like family; Region: YcaO; pfam02624 364106003047 Predicted membrane protein [Function unknown]; Region: COG2323 364106003048 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 364106003049 homodimer interface [polypeptide binding]; other site 364106003050 substrate-cofactor binding pocket; other site 364106003051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106003052 catalytic residue [active] 364106003053 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 364106003054 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 364106003055 hinge; other site 364106003056 active site 364106003057 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 364106003058 cytidylate kinase; Provisional; Region: cmk; PRK00023 364106003059 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 364106003060 CMP-binding site; other site 364106003061 The sites determining sugar specificity; other site 364106003062 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 364106003063 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 364106003064 RNA binding site [nucleotide binding]; other site 364106003065 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 364106003066 RNA binding site [nucleotide binding]; other site 364106003067 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 364106003068 RNA binding site [nucleotide binding]; other site 364106003069 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 364106003070 RNA binding site [nucleotide binding]; other site 364106003071 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 364106003072 RNA binding site [nucleotide binding]; other site 364106003073 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 364106003074 IHF dimer interface [polypeptide binding]; other site 364106003075 IHF - DNA interface [nucleotide binding]; other site 364106003076 ComEC family competence protein; Provisional; Region: PRK11539 364106003077 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 364106003078 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 364106003079 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 364106003080 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 364106003081 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 364106003082 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 364106003083 Walker A/P-loop; other site 364106003084 ATP binding site [chemical binding]; other site 364106003085 Q-loop/lid; other site 364106003086 ABC transporter signature motif; other site 364106003087 Walker B; other site 364106003088 D-loop; other site 364106003089 H-loop/switch region; other site 364106003090 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 364106003091 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 364106003092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 364106003093 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 364106003094 hypothetical protein; Provisional; Region: PRK11827 364106003095 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 364106003096 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 364106003097 Ligand binding site; other site 364106003098 oligomer interface; other site 364106003099 hypothetical protein; Provisional; Region: PRK10593 364106003100 Uncharacterized conserved protein [Function unknown]; Region: COG1434 364106003101 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 364106003102 putative active site [active] 364106003103 Methyltransferase domain; Region: Methyltransf_31; pfam13847 364106003104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106003105 S-adenosylmethionine binding site [chemical binding]; other site 364106003106 condesin subunit F; Provisional; Region: PRK05260 364106003107 condesin subunit E; Provisional; Region: PRK05256 364106003108 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 364106003109 MukB N-terminal; Region: MukB; pfam04310 364106003110 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 364106003111 murein L,D-transpeptidase; Provisional; Region: PRK10594 364106003112 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 364106003113 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 364106003114 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 364106003115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 364106003116 Peptidase M15; Region: Peptidase_M15_3; cl01194 364106003117 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 364106003118 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 364106003119 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 364106003120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106003121 homodimer interface [polypeptide binding]; other site 364106003122 catalytic residue [active] 364106003123 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 364106003124 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 364106003125 trimer interface [polypeptide binding]; other site 364106003126 eyelet of channel; other site 364106003127 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 364106003128 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 364106003129 putative dimer interface [polypeptide binding]; other site 364106003130 putative anticodon binding site; other site 364106003131 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 364106003132 homodimer interface [polypeptide binding]; other site 364106003133 motif 1; other site 364106003134 motif 2; other site 364106003135 active site 364106003136 motif 3; other site 364106003137 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 364106003138 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 364106003139 active site 364106003140 aminopeptidase N; Provisional; Region: pepN; PRK14015 364106003141 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 364106003142 active site 364106003143 Zn binding site [ion binding]; other site 364106003144 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 364106003145 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 364106003146 Walker A/P-loop; other site 364106003147 ATP binding site [chemical binding]; other site 364106003148 Q-loop/lid; other site 364106003149 ABC transporter signature motif; other site 364106003150 Walker B; other site 364106003151 D-loop; other site 364106003152 H-loop/switch region; other site 364106003153 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 364106003154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106003155 dimer interface [polypeptide binding]; other site 364106003156 conserved gate region; other site 364106003157 putative PBP binding loops; other site 364106003158 ABC-ATPase subunit interface; other site 364106003159 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 364106003160 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 364106003161 active site 364106003162 dimer interface [polypeptide binding]; other site 364106003163 non-prolyl cis peptide bond; other site 364106003164 insertion regions; other site 364106003165 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 364106003166 substrate binding pocket [chemical binding]; other site 364106003167 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 364106003168 membrane-bound complex binding site; other site 364106003169 hinge residues; other site 364106003170 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 364106003171 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 364106003172 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 364106003173 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 364106003174 quinone interaction residues [chemical binding]; other site 364106003175 active site 364106003176 catalytic residues [active] 364106003177 FMN binding site [chemical binding]; other site 364106003178 substrate binding site [chemical binding]; other site 364106003179 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 364106003180 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 364106003181 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 364106003182 MOSC domain; Region: MOSC; pfam03473 364106003183 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 364106003184 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 364106003185 catalytic loop [active] 364106003186 iron binding site [ion binding]; other site 364106003187 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 364106003188 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 364106003189 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 364106003190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106003191 S-adenosylmethionine binding site [chemical binding]; other site 364106003192 ABC transporter ATPase component; Reviewed; Region: PRK11147 364106003193 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 364106003194 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 364106003195 Walker A/P-loop; other site 364106003196 Walker A/P-loop; other site 364106003197 ATP binding site [chemical binding]; other site 364106003198 ATP binding site [chemical binding]; other site 364106003199 Q-loop/lid; other site 364106003200 Q-loop/lid; other site 364106003201 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 364106003202 ABC transporter signature motif; other site 364106003203 Walker B; other site 364106003204 D-loop; other site 364106003205 ABC transporter; Region: ABC_tran_2; pfam12848 364106003206 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 364106003207 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 364106003208 Paraquat-inducible protein A; Region: PqiA; pfam04403 364106003209 Paraquat-inducible protein A; Region: PqiA; pfam04403 364106003210 paraquat-inducible protein B; Provisional; Region: PRK10807 364106003211 mce related protein; Region: MCE; pfam02470 364106003212 mce related protein; Region: MCE; pfam02470 364106003213 mce related protein; Region: MCE; pfam02470 364106003214 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 364106003215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 364106003216 Protein of unknown function (DUF330); Region: DUF330; pfam03886 364106003217 ribosome modulation factor; Provisional; Region: PRK14563 364106003218 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 364106003219 active site 1 [active] 364106003220 dimer interface [polypeptide binding]; other site 364106003221 active site 2 [active] 364106003222 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 364106003223 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 364106003224 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 364106003225 outer membrane protein A; Reviewed; Region: PRK10808 364106003226 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 364106003227 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 364106003228 ligand binding site [chemical binding]; other site 364106003229 cell division inhibitor SulA; Region: sula; TIGR00623 364106003230 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 364106003231 TfoX C-terminal domain; Region: TfoX_C; pfam04994 364106003232 TIGR01666 family membrane protein; Region: YCCS 364106003233 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 364106003234 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 364106003235 Predicted membrane protein [Function unknown]; Region: COG3304 364106003236 Domain of unknown function (DUF307); Region: DUF307; pfam03733 364106003237 Domain of unknown function (DUF307); Region: DUF307; pfam03733 364106003238 DNA helicase IV; Provisional; Region: helD; PRK11054 364106003239 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 364106003240 Part of AAA domain; Region: AAA_19; pfam13245 364106003241 Family description; Region: UvrD_C_2; pfam13538 364106003242 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 364106003243 active site 364106003244 dimer interfaces [polypeptide binding]; other site 364106003245 catalytic residues [active] 364106003246 hypothetical protein; Provisional; Region: PRK03641 364106003247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 364106003248 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 364106003249 heat shock protein HspQ; Provisional; Region: PRK14129 364106003250 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 364106003251 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 364106003252 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 364106003253 putative RNA binding site [nucleotide binding]; other site 364106003254 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106003255 S-adenosylmethionine binding site [chemical binding]; other site 364106003256 acylphosphatase; Provisional; Region: PRK14439 364106003257 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 364106003258 sulfur transfer protein TusE; Provisional; Region: PRK11508 364106003259 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 364106003260 YccA-like proteins; Region: YccA_like; cd10433 364106003261 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 364106003262 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 364106003263 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 364106003264 hydrogenase 1 large subunit; Provisional; Region: PRK10170 364106003265 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 364106003266 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 364106003267 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 364106003268 putative substrate-binding site; other site 364106003269 nickel binding site [ion binding]; other site 364106003270 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 364106003271 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 364106003272 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 364106003273 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 364106003274 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 364106003275 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 364106003276 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 364106003277 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 364106003278 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 364106003279 catalytic core [active] 364106003280 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 364106003281 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 364106003282 DNA-binding site [nucleotide binding]; DNA binding site 364106003283 RNA-binding motif; other site 364106003284 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 364106003285 DNA-binding site [nucleotide binding]; DNA binding site 364106003286 RNA-binding motif; other site 364106003287 cold shock gene; Provisional; Region: PRK09891 364106003288 GnsA/GnsB family; Region: GnsAB; pfam08178 364106003289 4Fe-4S binding domain; Region: Fer4_5; pfam12801 364106003290 4Fe-4S binding domain; Region: Fer4_5; pfam12801 364106003291 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 364106003292 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 364106003293 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 364106003294 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 364106003295 dimerization interface [polypeptide binding]; other site 364106003296 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 364106003297 dimer interface [polypeptide binding]; other site 364106003298 phosphorylation site [posttranslational modification] 364106003299 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106003300 ATP binding site [chemical binding]; other site 364106003301 Mg2+ binding site [ion binding]; other site 364106003302 G-X-G motif; other site 364106003303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106003304 active site 364106003305 phosphorylation site [posttranslational modification] 364106003306 intermolecular recognition site; other site 364106003307 dimerization interface [polypeptide binding]; other site 364106003308 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 364106003309 putative binding surface; other site 364106003310 active site 364106003311 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 364106003312 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 364106003313 putative ligand binding site [chemical binding]; other site 364106003314 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 364106003315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106003316 active site 364106003317 phosphorylation site [posttranslational modification] 364106003318 intermolecular recognition site; other site 364106003319 dimerization interface [polypeptide binding]; other site 364106003320 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 364106003321 DNA binding site [nucleotide binding] 364106003322 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 364106003323 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 364106003324 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 364106003325 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 364106003326 molybdopterin cofactor binding site [chemical binding]; other site 364106003327 substrate binding site [chemical binding]; other site 364106003328 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 364106003329 molybdopterin cofactor binding site; other site 364106003330 chaperone protein TorD; Validated; Region: torD; PRK04976 364106003331 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 364106003332 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 364106003333 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 364106003334 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 364106003335 HSP70 interaction site [polypeptide binding]; other site 364106003336 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 364106003337 substrate binding site [polypeptide binding]; other site 364106003338 dimer interface [polypeptide binding]; other site 364106003339 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 364106003340 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 364106003341 catalytic core [active] 364106003342 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 364106003343 hypothetical protein; Provisional; Region: PRK10174 364106003344 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 364106003345 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 364106003346 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 364106003347 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 364106003348 putative FMN binding site [chemical binding]; other site 364106003349 pyrimidine utilization protein D; Region: RutD; TIGR03611 364106003350 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 364106003351 homotrimer interaction site [polypeptide binding]; other site 364106003352 putative active site [active] 364106003353 Isochorismatase family; Region: Isochorismatase; pfam00857 364106003354 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 364106003355 catalytic triad [active] 364106003356 conserved cis-peptide bond; other site 364106003357 pyrimidine utilization protein A; Region: RutA; TIGR03612 364106003358 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 364106003359 active site 364106003360 dimer interface [polypeptide binding]; other site 364106003361 non-prolyl cis peptide bond; other site 364106003362 insertion regions; other site 364106003363 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 364106003364 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 364106003365 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 364106003366 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 364106003367 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 364106003368 Predicted transcriptional regulator [Transcription]; Region: COG3905 364106003369 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 364106003370 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 364106003371 Glutamate binding site [chemical binding]; other site 364106003372 NAD binding site [chemical binding]; other site 364106003373 catalytic residues [active] 364106003374 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 364106003375 Na binding site [ion binding]; other site 364106003376 FTR1 family protein; Region: TIGR00145 364106003377 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 364106003378 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 364106003379 Imelysin; Region: Peptidase_M75; pfam09375 364106003380 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 364106003381 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 364106003382 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 364106003383 hypothetical protein; Provisional; Region: PRK10536 364106003384 putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585 364106003385 N-glycosyltransferase; Provisional; Region: PRK11204 364106003386 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 364106003387 DXD motif; other site 364106003388 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 364106003389 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 364106003390 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 364106003391 putative active site [active] 364106003392 putative metal binding site [ion binding]; other site 364106003393 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 364106003394 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 364106003395 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 364106003396 metal binding site [ion binding]; metal-binding site 364106003397 active site 364106003398 I-site; other site 364106003399 integrase; Provisional; Region: PRK09692 364106003400 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 364106003401 active site 364106003402 Int/Topo IB signature motif; other site 364106003403 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 364106003404 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 364106003405 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 364106003406 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 364106003407 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 364106003408 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 364106003409 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 364106003410 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 364106003411 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 364106003412 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 364106003413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106003414 homodimer interface [polypeptide binding]; other site 364106003415 catalytic residue [active] 364106003416 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 364106003417 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 364106003418 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 364106003419 putative active site [active] 364106003420 FaeA-like protein; Region: FaeA; pfam04703 364106003421 Adhesin biosynthesis transcription regulatory protein; Region: PapB; pfam03333 364106003422 Fimbrial protein; Region: Fimbrial; cl01416 364106003423 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 364106003424 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 364106003425 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 364106003426 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 364106003427 outer membrane usher protein; Provisional; Region: PRK15193 364106003428 PapC N-terminal domain; Region: PapC_N; pfam13954 364106003429 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 364106003430 PapC C-terminal domain; Region: PapC_C; pfam13953 364106003431 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 364106003432 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 364106003433 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 364106003434 mannosyl binding site [chemical binding]; other site 364106003435 Fimbrial protein; Region: Fimbrial; pfam00419 364106003436 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 364106003437 MarR family; Region: MarR_2; cl17246 364106003438 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 364106003439 outer membrane receptor FepA; Provisional; Region: PRK13528 364106003440 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 364106003441 N-terminal plug; other site 364106003442 ligand-binding site [chemical binding]; other site 364106003443 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 364106003444 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 364106003445 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 364106003446 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 364106003447 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 364106003448 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 364106003449 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 364106003450 Walker A/P-loop; other site 364106003451 ATP binding site [chemical binding]; other site 364106003452 Q-loop/lid; other site 364106003453 ABC transporter signature motif; other site 364106003454 Walker B; other site 364106003455 D-loop; other site 364106003456 H-loop/switch region; other site 364106003457 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 364106003458 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 364106003459 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 364106003460 Walker A/P-loop; other site 364106003461 ATP binding site [chemical binding]; other site 364106003462 Q-loop/lid; other site 364106003463 ABC transporter signature motif; other site 364106003464 Walker B; other site 364106003465 D-loop; other site 364106003466 H-loop/switch region; other site 364106003467 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 364106003468 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 364106003469 homodimer interface [polypeptide binding]; other site 364106003470 active site 364106003471 TDP-binding site; other site 364106003472 acceptor substrate-binding pocket; other site 364106003473 Domain of unknown function (DUF4322); Region: DUF4322; cl17882 364106003474 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 364106003475 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 364106003476 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 364106003477 N-terminal plug; other site 364106003478 ligand-binding site [chemical binding]; other site 364106003479 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 364106003480 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 364106003481 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 364106003482 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 364106003483 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 364106003484 Sel1-like repeats; Region: SEL1; smart00671 364106003485 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 364106003486 Sel1-like repeats; Region: SEL1; smart00671 364106003487 Sel1-like repeats; Region: SEL1; smart00671 364106003488 Sel1-like repeats; Region: SEL1; smart00671 364106003489 Sel1-like repeats; Region: SEL1; smart00671 364106003490 Sel1-like repeats; Region: SEL1; smart00671 364106003491 Sel1-like repeats; Region: SEL1; smart00671 364106003492 Sel1-like repeats; Region: SEL1; smart00671 364106003493 Sel1-like repeats; Region: SEL1; smart00671 364106003494 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 364106003495 Predicted GTPase [General function prediction only]; Region: COG3596 364106003496 YfjP GTPase; Region: YfjP; cd11383 364106003497 G1 box; other site 364106003498 GTP/Mg2+ binding site [chemical binding]; other site 364106003499 Switch I region; other site 364106003500 G2 box; other site 364106003501 Switch II region; other site 364106003502 G3 box; other site 364106003503 G4 box; other site 364106003504 G5 box; other site 364106003505 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 364106003506 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 364106003507 hypothetical protein; Provisional; Region: PRK09945 364106003508 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 364106003509 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 364106003510 Autotransporter beta-domain; Region: Autotransporter; smart00869 364106003511 Domain of unknown function (DUF932); Region: DUF932; pfam06067 364106003512 Antirestriction protein; Region: Antirestrict; pfam03230 364106003513 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 364106003514 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 364106003515 MPN+ (JAMM) motif; other site 364106003516 Zinc-binding site [ion binding]; other site 364106003517 Protein of unknown function (DUF987); Region: DUF987; pfam06174 364106003518 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 364106003519 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 364106003520 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 364106003521 Methyltransferase domain; Region: Methyltransf_27; pfam13708 364106003522 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 364106003523 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 364106003524 putative ligand binding site [chemical binding]; other site 364106003525 NAD binding site [chemical binding]; other site 364106003526 dimerization interface [polypeptide binding]; other site 364106003527 catalytic site [active] 364106003528 putative hydrolase; Validated; Region: PRK09248 364106003529 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 364106003530 active site 364106003531 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 364106003532 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 364106003533 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 364106003534 curli assembly protein CsgF; Provisional; Region: PRK10050 364106003535 curli assembly protein CsgE; Provisional; Region: PRK10386 364106003536 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 364106003537 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 364106003538 DNA binding residues [nucleotide binding] 364106003539 dimerization interface [polypeptide binding]; other site 364106003540 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 364106003541 Curlin associated repeat; Region: Curlin_rpt; pfam07012 364106003542 Curlin associated repeat; Region: Curlin_rpt; pfam07012 364106003543 major curlin subunit; Provisional; Region: csgA; PRK10051 364106003544 Curlin associated repeat; Region: Curlin_rpt; pfam07012 364106003545 Curlin associated repeat; Region: Curlin_rpt; pfam07012 364106003546 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 364106003547 Fimbrial protein; Region: Fimbrial; cl01416 364106003548 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 364106003549 putative ADP-ribose binding site [chemical binding]; other site 364106003550 putative active site [active] 364106003551 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 364106003552 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 364106003553 putative active site [active] 364106003554 catalytic site [active] 364106003555 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 364106003556 putative active site [active] 364106003557 catalytic site [active] 364106003558 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 364106003559 Acyltransferase family; Region: Acyl_transf_3; pfam01757 364106003560 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 364106003561 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 364106003562 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 364106003563 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 364106003564 Ligand binding site; other site 364106003565 DXD motif; other site 364106003566 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 364106003567 lipoprotein; Provisional; Region: PRK10175 364106003568 secY/secA suppressor protein; Provisional; Region: PRK11467 364106003569 drug efflux system protein MdtG; Provisional; Region: PRK09874 364106003570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106003571 putative substrate translocation pore; other site 364106003572 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 364106003573 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 364106003574 putative acyl-acceptor binding pocket; other site 364106003575 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 364106003576 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 364106003577 active site residue [active] 364106003578 hypothetical protein; Provisional; Region: PRK03757 364106003579 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 364106003580 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 364106003581 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 364106003582 hydroxyglutarate oxidase; Provisional; Region: PRK11728 364106003583 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 364106003584 DNA damage-inducible protein I; Provisional; Region: PRK10597 364106003585 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 364106003586 active site 364106003587 substrate binding pocket [chemical binding]; other site 364106003588 dimer interface [polypeptide binding]; other site 364106003589 lipoprotein; Provisional; Region: PRK10598 364106003590 glutaredoxin 2; Provisional; Region: PRK10387 364106003591 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 364106003592 C-terminal domain interface [polypeptide binding]; other site 364106003593 GSH binding site (G-site) [chemical binding]; other site 364106003594 catalytic residues [active] 364106003595 putative dimer interface [polypeptide binding]; other site 364106003596 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 364106003597 N-terminal domain interface [polypeptide binding]; other site 364106003598 multidrug resistance protein MdtH; Provisional; Region: PRK11646 364106003599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106003600 putative substrate translocation pore; other site 364106003601 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 364106003602 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 364106003603 hypothetical protein; Provisional; Region: PRK11239 364106003604 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 364106003605 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 364106003606 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 364106003607 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 364106003608 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 364106003609 MviN-like protein; Region: MVIN; pfam03023 364106003610 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 364106003611 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 364106003612 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 364106003613 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 364106003614 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 364106003615 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 364106003616 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 364106003617 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 364106003618 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 364106003619 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 364106003620 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 364106003621 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 364106003622 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 364106003623 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 364106003624 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 364106003625 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 364106003626 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 364106003627 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 364106003628 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 364106003629 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 364106003630 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 364106003631 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 364106003632 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 364106003633 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 364106003634 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 364106003635 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 364106003636 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 364106003637 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 364106003638 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 364106003639 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 364106003640 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 364106003641 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 364106003642 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 364106003643 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 364106003644 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 364106003645 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 364106003646 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 364106003647 homodimer interface [polypeptide binding]; other site 364106003648 oligonucleotide binding site [chemical binding]; other site 364106003649 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 364106003650 Protein of unknown function (DUF2655); Region: DUF2655; pfam10848 364106003651 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 364106003652 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 364106003653 RNA binding surface [nucleotide binding]; other site 364106003654 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 364106003655 active site 364106003656 Maf-like protein; Region: Maf; pfam02545 364106003657 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 364106003658 active site 364106003659 dimer interface [polypeptide binding]; other site 364106003660 hypothetical protein; Provisional; Region: PRK11193 364106003661 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 364106003662 putative phosphate acyltransferase; Provisional; Region: PRK05331 364106003663 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 364106003664 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 364106003665 dimer interface [polypeptide binding]; other site 364106003666 active site 364106003667 CoA binding pocket [chemical binding]; other site 364106003668 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 364106003669 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 364106003670 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 364106003671 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 364106003672 NAD(P) binding site [chemical binding]; other site 364106003673 homotetramer interface [polypeptide binding]; other site 364106003674 homodimer interface [polypeptide binding]; other site 364106003675 active site 364106003676 acyl carrier protein; Provisional; Region: acpP; PRK00982 364106003677 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 364106003678 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 364106003679 dimer interface [polypeptide binding]; other site 364106003680 active site 364106003681 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 364106003682 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 364106003683 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106003684 catalytic residue [active] 364106003685 conserved hypothetical protein, YceG family; Region: TIGR00247 364106003686 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 364106003687 dimerization interface [polypeptide binding]; other site 364106003688 thymidylate kinase; Validated; Region: tmk; PRK00698 364106003689 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 364106003690 TMP-binding site; other site 364106003691 ATP-binding site [chemical binding]; other site 364106003692 DNA polymerase III subunit delta'; Validated; Region: PRK07993 364106003693 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 364106003694 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 364106003695 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 364106003696 active site 364106003697 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 364106003698 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 364106003699 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 364106003700 active site turn [active] 364106003701 phosphorylation site [posttranslational modification] 364106003702 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 364106003703 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 364106003704 N-terminal plug; other site 364106003705 ligand-binding site [chemical binding]; other site 364106003706 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 364106003707 nucleotide binding site/active site [active] 364106003708 HIT family signature motif; other site 364106003709 catalytic residue [active] 364106003710 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 364106003711 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 364106003712 putative dimer interface [polypeptide binding]; other site 364106003713 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 364106003714 thiamine kinase; Region: ycfN_thiK; TIGR02721 364106003715 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 364106003716 active site 364106003717 substrate binding site [chemical binding]; other site 364106003718 ATP binding site [chemical binding]; other site 364106003719 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 364106003720 beta-hexosaminidase; Provisional; Region: PRK05337 364106003721 hypothetical protein; Provisional; Region: PRK04940 364106003722 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 364106003723 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 364106003724 hypothetical protein; Provisional; Region: PRK11280 364106003725 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 364106003726 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 364106003727 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 364106003728 L,D-transpeptidase; Provisional; Region: PRK10260 364106003729 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 364106003730 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 364106003731 transcription-repair coupling factor; Provisional; Region: PRK10689 364106003732 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 364106003733 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 364106003734 ATP binding site [chemical binding]; other site 364106003735 putative Mg++ binding site [ion binding]; other site 364106003736 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 364106003737 nucleotide binding region [chemical binding]; other site 364106003738 ATP-binding site [chemical binding]; other site 364106003739 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 364106003740 Predicted membrane protein [Function unknown]; Region: COG4763 364106003741 Acyltransferase family; Region: Acyl_transf_3; pfam01757 364106003742 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 364106003743 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 364106003744 FtsX-like permease family; Region: FtsX; pfam02687 364106003745 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 364106003746 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 364106003747 Walker A/P-loop; other site 364106003748 ATP binding site [chemical binding]; other site 364106003749 Q-loop/lid; other site 364106003750 ABC transporter signature motif; other site 364106003751 Walker B; other site 364106003752 D-loop; other site 364106003753 H-loop/switch region; other site 364106003754 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 364106003755 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 364106003756 FtsX-like permease family; Region: FtsX; pfam02687 364106003757 fructokinase; Reviewed; Region: PRK09557 364106003758 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 364106003759 nucleotide binding site [chemical binding]; other site 364106003760 NAD-dependent deacetylase; Provisional; Region: PRK00481 364106003761 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 364106003762 NAD+ binding site [chemical binding]; other site 364106003763 substrate binding site [chemical binding]; other site 364106003764 Zn binding site [ion binding]; other site 364106003765 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 364106003766 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 364106003767 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 364106003768 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 364106003769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106003770 dimer interface [polypeptide binding]; other site 364106003771 conserved gate region; other site 364106003772 putative PBP binding loops; other site 364106003773 ABC-ATPase subunit interface; other site 364106003774 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 364106003775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106003776 dimer interface [polypeptide binding]; other site 364106003777 conserved gate region; other site 364106003778 putative PBP binding loops; other site 364106003779 ABC-ATPase subunit interface; other site 364106003780 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 364106003781 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 364106003782 Walker A/P-loop; other site 364106003783 ATP binding site [chemical binding]; other site 364106003784 Q-loop/lid; other site 364106003785 ABC transporter signature motif; other site 364106003786 Walker B; other site 364106003787 D-loop; other site 364106003788 H-loop/switch region; other site 364106003789 TOBE domain; Region: TOBE_2; pfam08402 364106003790 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 364106003791 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 364106003792 metal binding site [ion binding]; metal-binding site 364106003793 dimer interface [polypeptide binding]; other site 364106003794 Uncharacterized conserved protein [Function unknown]; Region: COG2850 364106003795 Cupin-like domain; Region: Cupin_8; pfam13621 364106003796 sensor protein PhoQ; Provisional; Region: PRK10815 364106003797 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 364106003798 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 364106003799 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 364106003800 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106003801 ATP binding site [chemical binding]; other site 364106003802 Mg2+ binding site [ion binding]; other site 364106003803 G-X-G motif; other site 364106003804 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 364106003805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106003806 active site 364106003807 phosphorylation site [posttranslational modification] 364106003808 intermolecular recognition site; other site 364106003809 dimerization interface [polypeptide binding]; other site 364106003810 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 364106003811 DNA binding site [nucleotide binding] 364106003812 adenylosuccinate lyase; Provisional; Region: PRK09285 364106003813 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 364106003814 tetramer interface [polypeptide binding]; other site 364106003815 active site 364106003816 putative lysogenization regulator; Reviewed; Region: PRK00218 364106003817 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 364106003818 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 364106003819 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 364106003820 nudix motif; other site 364106003821 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 364106003822 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 364106003823 probable active site [active] 364106003824 isocitrate dehydrogenase; Validated; Region: PRK07362 364106003825 isocitrate dehydrogenase; Reviewed; Region: PRK07006 364106003826 possible prophage 364106003827 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 364106003828 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 364106003829 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 364106003830 dimer interface [polypeptide binding]; other site 364106003831 active site 364106003832 Int/Topo IB signature motif; other site 364106003833 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 364106003834 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 364106003835 DksA-like zinc finger domain containing protein; Region: PHA00080 364106003836 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 364106003837 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 364106003838 phage recombination protein Bet; Region: bet_lambda; TIGR01913 364106003839 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 364106003840 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 364106003841 Lambda Phage CIII; Region: Lambda_CIII; pfam02061 364106003842 Protein of unknown function (DUF2528); Region: DUF2528; pfam10800 364106003843 Antirestriction protein Ral; Region: Ral; pfam11058 364106003844 Superinfection exclusion protein B; Region: SieB; pfam14163 364106003845 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 364106003846 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 364106003847 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 364106003848 non-specific DNA binding site [nucleotide binding]; other site 364106003849 salt bridge; other site 364106003850 sequence-specific DNA binding site [nucleotide binding]; other site 364106003851 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 364106003852 Catalytic site [active] 364106003853 Bacteriophage CII protein; Region: Phage_CII; pfam05269 364106003854 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 364106003855 Replication protein P; Region: Phage_lambda_P; pfam06992 364106003856 NinB protein; Region: NinB; pfam05772 364106003857 phage N-6-adenine-methyltransferase; Region: phage_N6A_met; TIGR01712 364106003858 NINE Protein; Region: NinE; pfam05322 364106003859 Protein of unknown function (DUF2591); Region: DUF2591; cl11584 364106003860 NinF protein; Region: NinF; pfam05810 364106003861 endodeoxyribonuclease RUS; Reviewed; Region: PRK09786 364106003862 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 364106003863 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 364106003864 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 364106003865 trimer interface [polypeptide binding]; other site 364106003866 eyelet of channel; other site 364106003867 Lysis protein S; Region: Lysis_S; pfam04971 364106003868 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 364106003869 catalytic residues [active] 364106003870 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 364106003871 Bor protein; Region: Lambda_Bor; pfam06291 364106003872 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 364106003873 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 364106003874 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 364106003875 gpW; Region: gpW; pfam02831 364106003876 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 364106003877 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 364106003878 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 364106003879 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 364106003880 tandem repeat interface [polypeptide binding]; other site 364106003881 oligomer interface [polypeptide binding]; other site 364106003882 active site residues [active] 364106003883 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 364106003884 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 364106003885 DNA packaging protein FI; Region: Packaging_FI; pfam14000 364106003886 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 364106003887 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 364106003888 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 364106003889 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 364106003890 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 364106003891 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 364106003892 Minor tail protein T; Region: Phage_tail_T; cl05636 364106003893 Phage-related minor tail protein [Function unknown]; Region: COG5281 364106003894 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 364106003895 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 364106003896 Phage-related protein [Function unknown]; Region: COG4718 364106003897 Phage-related protein [Function unknown]; Region: gp18; COG4672 364106003898 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 364106003899 MPN+ (JAMM) motif; other site 364106003900 Zinc-binding site [ion binding]; other site 364106003901 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 364106003902 NlpC/P60 family; Region: NLPC_P60; cl17555 364106003903 Phage-related protein, tail component [Function unknown]; Region: COG4723 364106003904 Phage-related protein, tail component [Function unknown]; Region: COG4733 364106003905 Putative phage tail protein; Region: Phage-tail_3; pfam13550 364106003906 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 364106003907 Fibronectin type III protein; Region: DUF3672; pfam12421 364106003908 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 364106003909 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 364106003910 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 364106003911 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 364106003912 ABC-ATPase subunit interface; other site 364106003913 dimer interface [polypeptide binding]; other site 364106003914 putative PBP binding regions; other site 364106003915 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 364106003916 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 364106003917 ABC-ATPase subunit interface; other site 364106003918 dimer interface [polypeptide binding]; other site 364106003919 putative PBP binding regions; other site 364106003920 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 364106003921 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 364106003922 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 364106003923 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 364106003924 metal binding site [ion binding]; metal-binding site 364106003925 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 364106003926 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 364106003927 transcriptional regulator MirA; Provisional; Region: PRK15043 364106003928 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 364106003929 DNA binding residues [nucleotide binding] 364106003930 Sensors of blue-light using FAD; Region: BLUF; smart01034 364106003931 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 364106003932 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 364106003933 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 364106003934 Autotransporter beta-domain; Region: Autotransporter; cl17461 364106003935 Autotransporter beta-domain; Region: Autotransporter; smart00869 364106003936 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 364106003937 cell division inhibitor MinD; Provisional; Region: PRK10818 364106003938 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 364106003939 Switch I; other site 364106003940 Switch II; other site 364106003941 septum formation inhibitor; Reviewed; Region: minC; PRK03511 364106003942 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 364106003943 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 364106003944 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 364106003945 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 364106003946 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 364106003947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 364106003948 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 364106003949 hypothetical protein; Provisional; Region: PRK10691 364106003950 hypothetical protein; Provisional; Region: PRK05170 364106003951 Haemolysin E (HlyE); Region: HlyE; cl11627 364106003952 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 364106003953 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 364106003954 Catalytic site [active] 364106003955 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 364106003956 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 364106003957 active site 364106003958 DNA binding site [nucleotide binding] 364106003959 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 364106003960 disulfide bond formation protein B; Provisional; Region: PRK01749 364106003961 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 364106003962 transmembrane helices; other site 364106003963 fatty acid metabolism regulator; Provisional; Region: PRK04984 364106003964 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 364106003965 DNA-binding site [nucleotide binding]; DNA binding site 364106003966 FadR C-terminal domain; Region: FadR_C; pfam07840 364106003967 SpoVR family protein; Provisional; Region: PRK11767 364106003968 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 364106003969 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 364106003970 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 364106003971 alanine racemase; Reviewed; Region: dadX; PRK03646 364106003972 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 364106003973 active site 364106003974 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 364106003975 substrate binding site [chemical binding]; other site 364106003976 catalytic residues [active] 364106003977 dimer interface [polypeptide binding]; other site 364106003978 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 364106003979 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 364106003980 TrkA-C domain; Region: TrkA_C; pfam02080 364106003981 Transporter associated domain; Region: CorC_HlyC; smart01091 364106003982 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 364106003983 dimer interface [polypeptide binding]; other site 364106003984 catalytic triad [active] 364106003985 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 364106003986 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 364106003987 N-acetyl-D-glucosamine binding site [chemical binding]; other site 364106003988 catalytic residue [active] 364106003989 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 364106003990 Flagellar regulator YcgR; Region: YcgR; pfam07317 364106003991 PilZ domain; Region: PilZ; pfam07238 364106003992 hypothetical protein; Provisional; Region: PRK10457 364106003993 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 364106003994 N-terminal plug; other site 364106003995 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 364106003996 ligand-binding site [chemical binding]; other site 364106003997 molybdenum transport protein ModD; Provisional; Region: PRK06096 364106003998 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 364106003999 dimerization interface [polypeptide binding]; other site 364106004000 active site 364106004001 Methyltransferase domain; Region: Methyltransf_31; pfam13847 364106004002 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106004003 S-adenosylmethionine binding site [chemical binding]; other site 364106004004 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 364106004005 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 364106004006 Walker A/P-loop; other site 364106004007 ATP binding site [chemical binding]; other site 364106004008 Q-loop/lid; other site 364106004009 ABC transporter signature motif; other site 364106004010 Walker B; other site 364106004011 D-loop; other site 364106004012 H-loop/switch region; other site 364106004013 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 364106004014 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 364106004015 ABC-ATPase subunit interface; other site 364106004016 dimer interface [polypeptide binding]; other site 364106004017 putative PBP binding regions; other site 364106004018 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 364106004019 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 364106004020 putative metal binding site [ion binding]; other site 364106004021 trehalase; Provisional; Region: treA; PRK13271 364106004022 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 364106004023 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 364106004024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 364106004025 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 364106004026 dimerization domain swap beta strand [polypeptide binding]; other site 364106004027 regulatory protein interface [polypeptide binding]; other site 364106004028 active site 364106004029 regulatory phosphorylation site [posttranslational modification]; other site 364106004030 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 364106004031 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 364106004032 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 364106004033 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 364106004034 Dak1 domain; Region: Dak1; pfam02733 364106004035 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 364106004036 PAS domain; Region: PAS; smart00091 364106004037 putative active site [active] 364106004038 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106004039 Walker A motif; other site 364106004040 ATP binding site [chemical binding]; other site 364106004041 Walker B motif; other site 364106004042 arginine finger; other site 364106004043 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 364106004044 Probable pectinesterase/pectinesterase inhibitor; Region: PLN02708 364106004045 GTP-binding protein YchF; Reviewed; Region: PRK09601 364106004046 YchF GTPase; Region: YchF; cd01900 364106004047 G1 box; other site 364106004048 GTP/Mg2+ binding site [chemical binding]; other site 364106004049 Switch I region; other site 364106004050 G2 box; other site 364106004051 Switch II region; other site 364106004052 G3 box; other site 364106004053 G4 box; other site 364106004054 G5 box; other site 364106004055 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 364106004056 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 364106004057 putative active site [active] 364106004058 catalytic residue [active] 364106004059 hypothetical protein; Provisional; Region: PRK10692 364106004060 putative transporter; Provisional; Region: PRK11660 364106004061 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 364106004062 Sulfate transporter family; Region: Sulfate_transp; pfam00916 364106004063 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 364106004064 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 364106004065 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 364106004066 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 364106004067 active site 364106004068 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 364106004069 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 364106004070 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 364106004071 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 364106004072 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 364106004073 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 364106004074 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 364106004075 tRNA; other site 364106004076 putative tRNA binding site [nucleotide binding]; other site 364106004077 putative NADP binding site [chemical binding]; other site 364106004078 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 364106004079 peptide chain release factor 1; Validated; Region: prfA; PRK00591 364106004080 This domain is found in peptide chain release factors; Region: PCRF; smart00937 364106004081 RF-1 domain; Region: RF-1; pfam00472 364106004082 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 364106004083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106004084 hypothetical protein; Provisional; Region: PRK10278 364106004085 hypothetical protein; Provisional; Region: PRK10941 364106004086 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 364106004087 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 364106004088 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 364106004089 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 364106004090 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 364106004091 cation transport regulator; Reviewed; Region: chaB; PRK09582 364106004092 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 364106004093 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 364106004094 putative active site pocket [active] 364106004095 dimerization interface [polypeptide binding]; other site 364106004096 putative catalytic residue [active] 364106004097 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 364106004098 putative invasin; Provisional; Region: PRK10177 364106004099 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 364106004100 transcriptional regulator NarL; Provisional; Region: PRK10651 364106004101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106004102 active site 364106004103 phosphorylation site [posttranslational modification] 364106004104 intermolecular recognition site; other site 364106004105 dimerization interface [polypeptide binding]; other site 364106004106 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 364106004107 DNA binding residues [nucleotide binding] 364106004108 dimerization interface [polypeptide binding]; other site 364106004109 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 364106004110 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 364106004111 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 364106004112 dimerization interface [polypeptide binding]; other site 364106004113 Histidine kinase; Region: HisKA_3; pfam07730 364106004114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106004115 ATP binding site [chemical binding]; other site 364106004116 Mg2+ binding site [ion binding]; other site 364106004117 G-X-G motif; other site 364106004118 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 364106004119 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 364106004120 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 364106004121 [4Fe-4S] binding site [ion binding]; other site 364106004122 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 364106004123 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 364106004124 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 364106004125 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 364106004126 molybdopterin cofactor binding site; other site 364106004127 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 364106004128 4Fe-4S binding domain; Region: Fer4; cl02805 364106004129 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 364106004130 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 364106004131 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 364106004132 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 364106004133 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 364106004134 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 364106004135 putative active site [active] 364106004136 putative substrate binding site [chemical binding]; other site 364106004137 putative cosubstrate binding site; other site 364106004138 catalytic site [active] 364106004139 SEC-C motif; Region: SEC-C; pfam02810 364106004140 hypothetical protein; Provisional; Region: PRK04233 364106004141 hypothetical protein; Provisional; Region: PRK10279 364106004142 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 364106004143 active site 364106004144 nucleophile elbow; other site 364106004145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106004146 active site 364106004147 response regulator of RpoS; Provisional; Region: PRK10693 364106004148 phosphorylation site [posttranslational modification] 364106004149 intermolecular recognition site; other site 364106004150 dimerization interface [polypeptide binding]; other site 364106004151 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 364106004152 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 364106004153 active site 364106004154 tetramer interface; other site 364106004155 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 364106004156 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 364106004157 thymidine kinase; Provisional; Region: PRK04296 364106004158 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 364106004159 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 364106004160 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 364106004161 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 364106004162 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 364106004163 putative catalytic cysteine [active] 364106004164 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 364106004165 putative active site [active] 364106004166 metal binding site [ion binding]; metal-binding site 364106004167 hypothetical protein; Provisional; Region: PRK11111 364106004168 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 364106004169 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 364106004170 peptide binding site [polypeptide binding]; other site 364106004171 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 364106004172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106004173 dimer interface [polypeptide binding]; other site 364106004174 conserved gate region; other site 364106004175 putative PBP binding loops; other site 364106004176 ABC-ATPase subunit interface; other site 364106004177 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 364106004178 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 364106004179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106004180 dimer interface [polypeptide binding]; other site 364106004181 conserved gate region; other site 364106004182 putative PBP binding loops; other site 364106004183 ABC-ATPase subunit interface; other site 364106004184 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 364106004185 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 364106004186 Walker A/P-loop; other site 364106004187 ATP binding site [chemical binding]; other site 364106004188 Q-loop/lid; other site 364106004189 ABC transporter signature motif; other site 364106004190 Walker B; other site 364106004191 D-loop; other site 364106004192 H-loop/switch region; other site 364106004193 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 364106004194 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 364106004195 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 364106004196 Walker A/P-loop; other site 364106004197 ATP binding site [chemical binding]; other site 364106004198 Q-loop/lid; other site 364106004199 ABC transporter signature motif; other site 364106004200 Walker B; other site 364106004201 D-loop; other site 364106004202 H-loop/switch region; other site 364106004203 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 364106004204 dsDNA-mimic protein; Reviewed; Region: PRK05094 364106004205 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 364106004206 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 364106004207 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 364106004208 putative active site [active] 364106004209 catalytic site [active] 364106004210 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 364106004211 putative active site [active] 364106004212 catalytic site [active] 364106004213 voltage-gated potassium channel; Provisional; Region: PRK10537 364106004214 Ion channel; Region: Ion_trans_2; pfam07885 364106004215 TrkA-N domain; Region: TrkA_N; pfam02254 364106004216 YciI-like protein; Reviewed; Region: PRK11370 364106004217 transport protein TonB; Provisional; Region: PRK10819 364106004218 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 364106004219 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 364106004220 intracellular septation protein A; Reviewed; Region: PRK00259 364106004221 hypothetical protein; Provisional; Region: PRK02868 364106004222 outer membrane protein W; Provisional; Region: PRK10959 364106004223 possible prophage 364106004224 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 364106004225 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 364106004226 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 364106004227 dimer interface [polypeptide binding]; other site 364106004228 active site 364106004229 Int/Topo IB signature motif; other site 364106004230 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 364106004231 active site 364106004232 catalytic site [active] 364106004233 substrate binding site [chemical binding]; other site 364106004234 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 364106004235 DicB protein; Region: DicB; pfam05358 364106004236 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 364106004237 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 364106004238 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 364106004239 non-specific DNA binding site [nucleotide binding]; other site 364106004240 salt bridge; other site 364106004241 sequence-specific DNA binding site [nucleotide binding]; other site 364106004242 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 364106004243 Catalytic site [active] 364106004244 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 364106004245 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 364106004246 primosomal protein DnaI; Provisional; Region: PRK02854 364106004247 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 364106004248 Hok/gef family; Region: HOK_GEF; pfam01848 364106004249 Protein of unknown function (DUF968); Region: DUF968; pfam06147 364106004250 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 364106004251 Antitermination protein; Region: Antiterm; pfam03589 364106004252 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 364106004253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106004254 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 364106004255 DNA methylase; Region: N6_N4_Mtase; pfam01555 364106004256 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 364106004257 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 364106004258 possible prophage 364106004259 Lysis protein S; Region: Lysis_S; pfam04971 364106004260 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 364106004261 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 364106004262 catalytic residues [active] 364106004263 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 364106004264 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 364106004265 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 364106004266 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 364106004267 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 364106004268 gpW; Region: gpW; pfam02831 364106004269 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 364106004270 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 364106004271 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 364106004272 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 364106004273 tandem repeat interface [polypeptide binding]; other site 364106004274 oligomer interface [polypeptide binding]; other site 364106004275 active site residues [active] 364106004276 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 364106004277 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 364106004278 DNA packaging protein FI; Region: Packaging_FI; pfam14000 364106004279 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 364106004280 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 364106004281 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 364106004282 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 364106004283 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 364106004284 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 364106004285 phage tail assembly protein T; Region: phage_lam_T; TIGR01715 364106004286 Phage-related minor tail protein [Function unknown]; Region: COG5281 364106004287 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 364106004288 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 364106004289 Phage-related protein [Function unknown]; Region: COG4718 364106004290 Phage-related protein [Function unknown]; Region: gp18; COG4672 364106004291 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 364106004292 MPN+ (JAMM) motif; other site 364106004293 Zinc-binding site [ion binding]; other site 364106004294 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 364106004295 NlpC/P60 family; Region: NLPC_P60; cl17555 364106004296 Phage-related protein, tail component [Function unknown]; Region: COG4723 364106004297 Phage-related protein, tail component [Function unknown]; Region: COG4733 364106004298 Putative phage tail protein; Region: Phage-tail_3; pfam13550 364106004299 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 364106004300 Fibronectin type III protein; Region: DUF3672; pfam12421 364106004301 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 364106004302 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 364106004303 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 364106004304 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 364106004305 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 364106004306 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 364106004307 Phage Tail Collar Domain; Region: Collar; pfam07484 364106004308 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 364106004309 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 364106004310 Methyltransferase domain; Region: Methyltransf_31; pfam13847 364106004311 Methyltransferase domain; Region: Methyltransf_12; pfam08242 364106004312 S-adenosylmethionine binding site [chemical binding]; other site 364106004313 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 364106004314 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 364106004315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 364106004316 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 364106004317 dimerization interface [polypeptide binding]; other site 364106004318 metal binding site [ion binding]; metal-binding site 364106004319 General stress protein [General function prediction only]; Region: GsiB; COG3729 364106004320 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 364106004321 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 364106004322 substrate binding site [chemical binding]; other site 364106004323 active site 364106004324 catalytic residues [active] 364106004325 heterodimer interface [polypeptide binding]; other site 364106004326 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 364106004327 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 364106004328 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106004329 catalytic residue [active] 364106004330 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 364106004331 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 364106004332 active site 364106004333 ribulose/triose binding site [chemical binding]; other site 364106004334 phosphate binding site [ion binding]; other site 364106004335 substrate (anthranilate) binding pocket [chemical binding]; other site 364106004336 product (indole) binding pocket [chemical binding]; other site 364106004337 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 364106004338 active site 364106004339 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 364106004340 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 364106004341 glutamine binding [chemical binding]; other site 364106004342 catalytic triad [active] 364106004343 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 364106004344 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 364106004345 anthranilate synthase component I; Provisional; Region: PRK13564 364106004346 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 364106004347 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 364106004348 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 364106004349 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 364106004350 active site 364106004351 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 364106004352 hypothetical protein; Provisional; Region: PRK11630 364106004353 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 364106004354 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 364106004355 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 364106004356 RNA binding surface [nucleotide binding]; other site 364106004357 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 364106004358 probable active site [active] 364106004359 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 364106004360 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 364106004361 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 364106004362 homodimer interface [polypeptide binding]; other site 364106004363 Walker A motif; other site 364106004364 ATP binding site [chemical binding]; other site 364106004365 hydroxycobalamin binding site [chemical binding]; other site 364106004366 Walker B motif; other site 364106004367 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 364106004368 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 364106004369 NADP binding site [chemical binding]; other site 364106004370 homodimer interface [polypeptide binding]; other site 364106004371 active site 364106004372 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 364106004373 putative inner membrane peptidase; Provisional; Region: PRK11778 364106004374 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 364106004375 tandem repeat interface [polypeptide binding]; other site 364106004376 oligomer interface [polypeptide binding]; other site 364106004377 active site residues [active] 364106004378 hypothetical protein; Provisional; Region: PRK11037 364106004379 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 364106004380 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 364106004381 active site 364106004382 interdomain interaction site; other site 364106004383 putative metal-binding site [ion binding]; other site 364106004384 nucleotide binding site [chemical binding]; other site 364106004385 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 364106004386 domain I; other site 364106004387 DNA binding groove [nucleotide binding] 364106004388 phosphate binding site [ion binding]; other site 364106004389 domain II; other site 364106004390 domain III; other site 364106004391 nucleotide binding site [chemical binding]; other site 364106004392 catalytic site [active] 364106004393 domain IV; other site 364106004394 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 364106004395 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 364106004396 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 364106004397 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 364106004398 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 364106004399 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106004400 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 364106004401 substrate binding site [chemical binding]; other site 364106004402 putative dimerization interface [polypeptide binding]; other site 364106004403 aconitate hydratase; Validated; Region: PRK09277 364106004404 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 364106004405 substrate binding site [chemical binding]; other site 364106004406 ligand binding site [chemical binding]; other site 364106004407 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 364106004408 substrate binding site [chemical binding]; other site 364106004409 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 364106004410 dimerization interface [polypeptide binding]; other site 364106004411 active site 364106004412 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 364106004413 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 364106004414 active site 364106004415 Predicted membrane protein [Function unknown]; Region: COG3771 364106004416 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 364106004417 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 364106004418 TPR motif; other site 364106004419 binding surface 364106004420 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 364106004421 binding surface 364106004422 TPR motif; other site 364106004423 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 364106004424 active site 364106004425 dimer interface [polypeptide binding]; other site 364106004426 translation initiation factor Sui1; Validated; Region: PRK06824 364106004427 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 364106004428 putative rRNA binding site [nucleotide binding]; other site 364106004429 lipoprotein; Provisional; Region: PRK10540 364106004430 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 364106004431 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 364106004432 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 364106004433 hypothetical protein; Provisional; Region: PRK13658 364106004434 RNase II stability modulator; Provisional; Region: PRK10060 364106004435 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 364106004436 putative active site [active] 364106004437 heme pocket [chemical binding]; other site 364106004438 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 364106004439 metal binding site [ion binding]; metal-binding site 364106004440 active site 364106004441 I-site; other site 364106004442 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 364106004443 exoribonuclease II; Provisional; Region: PRK05054 364106004444 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 364106004445 RNB domain; Region: RNB; pfam00773 364106004446 S1 RNA binding domain; Region: S1; pfam00575 364106004447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 364106004448 Uncharacterized conserved protein [Function unknown]; Region: COG2128 364106004449 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 364106004450 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 364106004451 NAD binding site [chemical binding]; other site 364106004452 homotetramer interface [polypeptide binding]; other site 364106004453 homodimer interface [polypeptide binding]; other site 364106004454 substrate binding site [chemical binding]; other site 364106004455 active site 364106004456 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 364106004457 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 364106004458 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 364106004459 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 364106004460 HlyD family secretion protein; Region: HlyD_3; pfam13437 364106004461 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 364106004462 Protein export membrane protein; Region: SecD_SecF; cl14618 364106004463 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 364106004464 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 364106004465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106004466 putative substrate translocation pore; other site 364106004467 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 364106004468 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 364106004469 Walker A/P-loop; other site 364106004470 ATP binding site [chemical binding]; other site 364106004471 Q-loop/lid; other site 364106004472 ABC transporter signature motif; other site 364106004473 Walker B; other site 364106004474 D-loop; other site 364106004475 H-loop/switch region; other site 364106004476 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 364106004477 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 364106004478 Walker A/P-loop; other site 364106004479 ATP binding site [chemical binding]; other site 364106004480 Q-loop/lid; other site 364106004481 ABC transporter signature motif; other site 364106004482 Walker B; other site 364106004483 D-loop; other site 364106004484 H-loop/switch region; other site 364106004485 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 364106004486 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 364106004487 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 364106004488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106004489 dimer interface [polypeptide binding]; other site 364106004490 conserved gate region; other site 364106004491 putative PBP binding loops; other site 364106004492 ABC-ATPase subunit interface; other site 364106004493 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 364106004494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106004495 dimer interface [polypeptide binding]; other site 364106004496 conserved gate region; other site 364106004497 putative PBP binding loops; other site 364106004498 ABC-ATPase subunit interface; other site 364106004499 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 364106004500 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 364106004501 peptide binding site [polypeptide binding]; other site 364106004502 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 364106004503 possible prophage 364106004504 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 364106004505 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106004506 Walker A motif; other site 364106004507 ATP binding site [chemical binding]; other site 364106004508 Walker B motif; other site 364106004509 arginine finger; other site 364106004510 phage shock protein PspA; Provisional; Region: PRK10698 364106004511 phage shock protein B; Provisional; Region: pspB; PRK09458 364106004512 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 364106004513 phage shock protein C; Region: phageshock_pspC; TIGR02978 364106004514 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 364106004515 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 364106004516 active site residue [active] 364106004517 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 364106004518 sucrose phosphorylase; Provisional; Region: PRK13840 364106004519 active site 364106004520 homodimer interface [polypeptide binding]; other site 364106004521 catalytic site [active] 364106004522 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 364106004523 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 364106004524 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 364106004525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106004526 dimer interface [polypeptide binding]; other site 364106004527 conserved gate region; other site 364106004528 putative PBP binding loops; other site 364106004529 ABC-ATPase subunit interface; other site 364106004530 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 364106004531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106004532 dimer interface [polypeptide binding]; other site 364106004533 conserved gate region; other site 364106004534 putative PBP binding loops; other site 364106004535 ABC-ATPase subunit interface; other site 364106004536 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 364106004537 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 364106004538 putative NAD(P) binding site [chemical binding]; other site 364106004539 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 364106004540 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 364106004541 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 364106004542 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 364106004543 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 364106004544 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 364106004545 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 364106004546 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 364106004547 beta-phosphoglucomutase; Region: bPGM; TIGR01990 364106004548 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 364106004549 motif II; other site 364106004550 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 364106004551 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 364106004552 Walker A/P-loop; other site 364106004553 ATP binding site [chemical binding]; other site 364106004554 Q-loop/lid; other site 364106004555 ABC transporter signature motif; other site 364106004556 Walker B; other site 364106004557 D-loop; other site 364106004558 H-loop/switch region; other site 364106004559 TOBE domain; Region: TOBE_2; pfam08402 364106004560 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 364106004561 Transcriptional regulators [Transcription]; Region: PurR; COG1609 364106004562 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 364106004563 DNA binding site [nucleotide binding] 364106004564 domain linker motif; other site 364106004565 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 364106004566 putative dimerization interface [polypeptide binding]; other site 364106004567 putative ligand binding site [chemical binding]; other site 364106004568 Predicted ATPase [General function prediction only]; Region: COG3106 364106004569 hypothetical protein; Provisional; Region: PRK05415 364106004570 TIGR01620 family protein; Region: hyp_HI0043 364106004571 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 364106004572 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 364106004573 putative aromatic amino acid binding site; other site 364106004574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106004575 Walker A motif; other site 364106004576 ATP binding site [chemical binding]; other site 364106004577 Walker B motif; other site 364106004578 arginine finger; other site 364106004579 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 364106004580 dimer interface [polypeptide binding]; other site 364106004581 catalytic triad [active] 364106004582 peroxidatic and resolving cysteines [active] 364106004583 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 364106004584 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 364106004585 active site 364106004586 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 364106004587 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 364106004588 putative active site [active] 364106004589 Zn binding site [ion binding]; other site 364106004590 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 364106004591 NADH(P)-binding; Region: NAD_binding_10; pfam13460 364106004592 putative NAD(P) binding site [chemical binding]; other site 364106004593 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 364106004594 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 364106004595 Transcriptional regulator [Transcription]; Region: LysR; COG0583 364106004596 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106004597 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 364106004598 putative effector binding pocket; other site 364106004599 putative dimerization interface [polypeptide binding]; other site 364106004600 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 364106004601 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 364106004602 peptide binding site [polypeptide binding]; other site 364106004603 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 364106004604 Mechanosensitive ion channel; Region: MS_channel; pfam00924 364106004605 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 364106004606 universal stress protein UspE; Provisional; Region: PRK11175 364106004607 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 364106004608 Ligand Binding Site [chemical binding]; other site 364106004609 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 364106004610 Ligand Binding Site [chemical binding]; other site 364106004611 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 364106004612 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 364106004613 ligand binding site [chemical binding]; other site 364106004614 flexible hinge region; other site 364106004615 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 364106004616 putative switch regulator; other site 364106004617 non-specific DNA interactions [nucleotide binding]; other site 364106004618 DNA binding site [nucleotide binding] 364106004619 sequence specific DNA binding site [nucleotide binding]; other site 364106004620 putative cAMP binding site [chemical binding]; other site 364106004621 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 364106004622 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 364106004623 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 364106004624 DNA binding site [nucleotide binding] 364106004625 active site 364106004626 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 364106004627 Helix-turn-helix domain; Region: HTH_18; pfam12833 364106004628 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 364106004629 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 364106004630 HlyD family secretion protein; Region: HlyD_3; pfam13437 364106004631 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 364106004632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106004633 putative substrate translocation pore; other site 364106004634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106004635 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 364106004636 Smr domain; Region: Smr; pfam01713 364106004637 PAS domain S-box; Region: sensory_box; TIGR00229 364106004638 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 364106004639 putative active site [active] 364106004640 heme pocket [chemical binding]; other site 364106004641 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 364106004642 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 364106004643 metal binding site [ion binding]; metal-binding site 364106004644 active site 364106004645 I-site; other site 364106004646 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 364106004647 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 364106004648 Cl binding site [ion binding]; other site 364106004649 oligomer interface [polypeptide binding]; other site 364106004650 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 364106004651 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 364106004652 ATP binding site [chemical binding]; other site 364106004653 Mg++ binding site [ion binding]; other site 364106004654 motif III; other site 364106004655 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 364106004656 nucleotide binding region [chemical binding]; other site 364106004657 ATP-binding site [chemical binding]; other site 364106004658 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 364106004659 putative RNA binding site [nucleotide binding]; other site 364106004660 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 364106004661 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 364106004662 Ligand Binding Site [chemical binding]; other site 364106004663 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 364106004664 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 364106004665 DNA binding site [nucleotide binding] 364106004666 active site 364106004667 Int/Topo IB signature motif; other site 364106004668 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 364106004669 Ligand Binding Site [chemical binding]; other site 364106004670 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 364106004671 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 364106004672 trimer interface [polypeptide binding]; other site 364106004673 eyelet of channel; other site 364106004674 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 364106004675 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 364106004676 dimer interface [polypeptide binding]; other site 364106004677 PYR/PP interface [polypeptide binding]; other site 364106004678 TPP binding site [chemical binding]; other site 364106004679 substrate binding site [chemical binding]; other site 364106004680 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 364106004681 Domain of unknown function; Region: EKR; smart00890 364106004682 4Fe-4S binding domain; Region: Fer4_6; pfam12837 364106004683 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 364106004684 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 364106004685 TPP-binding site [chemical binding]; other site 364106004686 dimer interface [polypeptide binding]; other site 364106004687 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 364106004688 Domain of unknown function (DUF333); Region: DUF333; pfam03891 364106004689 heat-inducible protein; Provisional; Region: PRK10449 364106004690 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 364106004691 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 364106004692 putative ligand binding site [chemical binding]; other site 364106004693 putative NAD binding site [chemical binding]; other site 364106004694 catalytic site [active] 364106004695 hypothetical protein; Provisional; Region: PRK10695 364106004696 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 364106004697 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 364106004698 Autotransporter beta-domain; Region: Autotransporter; pfam03797 364106004699 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 364106004700 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 364106004701 active site 364106004702 catalytic tetrad [active] 364106004703 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 364106004704 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 364106004705 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 364106004706 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 364106004707 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 364106004708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106004709 S-adenosylmethionine binding site [chemical binding]; other site 364106004710 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 364106004711 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 364106004712 active site 364106004713 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 364106004714 active site 364106004715 catalytic residues [active] 364106004716 azoreductase; Reviewed; Region: PRK00170 364106004717 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 364106004718 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 364106004719 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 364106004720 ATP binding site [chemical binding]; other site 364106004721 putative Mg++ binding site [ion binding]; other site 364106004722 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 364106004723 nucleotide binding region [chemical binding]; other site 364106004724 ATP-binding site [chemical binding]; other site 364106004725 Helicase associated domain (HA2); Region: HA2; pfam04408 364106004726 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 364106004727 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 364106004728 Uncharacterized conserved protein [Function unknown]; Region: COG1434 364106004729 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 364106004730 putative active site [active] 364106004731 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 364106004732 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 364106004733 NAD binding site [chemical binding]; other site 364106004734 catalytic residues [active] 364106004735 substrate binding site [chemical binding]; other site 364106004736 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 364106004737 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 364106004738 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 364106004739 cytochrome b561; Provisional; Region: PRK11513 364106004740 hypothetical protein; Provisional; Region: PRK10040 364106004741 small toxic polypeptide; Provisional; Region: PRK09738 364106004742 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 364106004743 dimer interface [polypeptide binding]; other site 364106004744 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 364106004745 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106004746 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 364106004747 dimerization interface [polypeptide binding]; other site 364106004748 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 364106004749 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 364106004750 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 364106004751 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 364106004752 hypothetical protein; Provisional; Region: PRK11415 364106004753 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 364106004754 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 364106004755 Coenzyme A binding pocket [chemical binding]; other site 364106004756 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 364106004757 putative trimer interface [polypeptide binding]; other site 364106004758 putative CoA binding site [chemical binding]; other site 364106004759 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 364106004760 putative trimer interface [polypeptide binding]; other site 364106004761 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 364106004762 putative CoA binding site [chemical binding]; other site 364106004763 putative trimer interface [polypeptide binding]; other site 364106004764 putative CoA binding site [chemical binding]; other site 364106004765 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 364106004766 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 364106004767 gating phenylalanine in ion channel; other site 364106004768 tellurite resistance protein TehB; Provisional; Region: PRK11207 364106004769 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106004770 S-adenosylmethionine binding site [chemical binding]; other site 364106004771 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 364106004772 benzoate transporter; Region: benE; TIGR00843 364106004773 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 364106004774 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 364106004775 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 364106004776 non-specific DNA binding site [nucleotide binding]; other site 364106004777 salt bridge; other site 364106004778 sequence-specific DNA binding site [nucleotide binding]; other site 364106004779 Cupin domain; Region: Cupin_2; pfam07883 364106004780 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 364106004781 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 364106004782 Peptidase family U32; Region: Peptidase_U32; pfam01136 364106004783 Collagenase; Region: DUF3656; pfam12392 364106004784 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 364106004785 Helix-turn-helix; Region: HTH_3; pfam01381 364106004786 sequence-specific DNA binding site [nucleotide binding]; other site 364106004787 salt bridge; other site 364106004788 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 364106004789 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 364106004790 DNA-binding site [nucleotide binding]; DNA binding site 364106004791 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 364106004792 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106004793 homodimer interface [polypeptide binding]; other site 364106004794 catalytic residue [active] 364106004795 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 364106004796 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 364106004797 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 364106004798 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 364106004799 Walker A/P-loop; other site 364106004800 ATP binding site [chemical binding]; other site 364106004801 Q-loop/lid; other site 364106004802 ABC transporter signature motif; other site 364106004803 Walker B; other site 364106004804 D-loop; other site 364106004805 H-loop/switch region; other site 364106004806 TOBE domain; Region: TOBE_2; pfam08402 364106004807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106004808 dimer interface [polypeptide binding]; other site 364106004809 conserved gate region; other site 364106004810 putative PBP binding loops; other site 364106004811 ABC-ATPase subunit interface; other site 364106004812 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 364106004813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106004814 ABC-ATPase subunit interface; other site 364106004815 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 364106004816 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 364106004817 tetrameric interface [polypeptide binding]; other site 364106004818 NAD binding site [chemical binding]; other site 364106004819 catalytic residues [active] 364106004820 substrate binding site [chemical binding]; other site 364106004821 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 364106004822 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 364106004823 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 364106004824 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 364106004825 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 364106004826 Coenzyme A binding pocket [chemical binding]; other site 364106004827 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 364106004828 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 364106004829 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 364106004830 N-terminal plug; other site 364106004831 ligand-binding site [chemical binding]; other site 364106004832 PQQ-like domain; Region: PQQ_2; pfam13360 364106004833 L-asparagine permease; Provisional; Region: PRK15049 364106004834 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 364106004835 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 364106004836 dimer interface [polypeptide binding]; other site 364106004837 N-terminal domain interface [polypeptide binding]; other site 364106004838 substrate binding pocket (H-site) [chemical binding]; other site 364106004839 PAAR motif; Region: PAAR_motif; pfam05488 364106004840 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 364106004841 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 364106004842 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 364106004843 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 364106004844 Peptidase M35-like domain of uncharacterized proteins; Region: M35_like_1; cd11007 364106004845 putative active site [active] 364106004846 putative Zn binding site [ion binding]; other site 364106004847 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 364106004848 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 364106004849 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 364106004850 hypothetical protein; Provisional; Region: PRK10281 364106004851 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 364106004852 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 364106004853 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 364106004854 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 364106004855 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 364106004856 [4Fe-4S] binding site [ion binding]; other site 364106004857 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 364106004858 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 364106004859 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 364106004860 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 364106004861 molybdopterin cofactor binding site; other site 364106004862 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 364106004863 aromatic amino acid exporter; Provisional; Region: PRK11689 364106004864 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 364106004865 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 364106004866 [4Fe-4S] binding site [ion binding]; other site 364106004867 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 364106004868 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 364106004869 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 364106004870 molybdopterin cofactor binding site; other site 364106004871 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 364106004872 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 364106004873 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 364106004874 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 364106004875 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 364106004876 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 364106004877 non-specific DNA binding site [nucleotide binding]; other site 364106004878 salt bridge; other site 364106004879 sequence-specific DNA binding site [nucleotide binding]; other site 364106004880 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 364106004881 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 364106004882 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 364106004883 NAD binding site [chemical binding]; other site 364106004884 substrate binding site [chemical binding]; other site 364106004885 catalytic Zn binding site [ion binding]; other site 364106004886 tetramer interface [polypeptide binding]; other site 364106004887 structural Zn binding site [ion binding]; other site 364106004888 malate dehydrogenase; Provisional; Region: PRK13529 364106004889 Malic enzyme, N-terminal domain; Region: malic; pfam00390 364106004890 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 364106004891 NAD(P) binding site [chemical binding]; other site 364106004892 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 364106004893 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 364106004894 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 364106004895 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 364106004896 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 364106004897 putative active site [active] 364106004898 heme pocket [chemical binding]; other site 364106004899 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 364106004900 putative active site [active] 364106004901 heme pocket [chemical binding]; other site 364106004902 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 364106004903 metal binding site [ion binding]; metal-binding site 364106004904 active site 364106004905 I-site; other site 364106004906 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 364106004907 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 364106004908 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 364106004909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 364106004910 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 364106004911 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 364106004912 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 364106004913 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106004914 catalytic residue [active] 364106004915 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 364106004916 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 364106004917 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 364106004918 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 364106004919 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 364106004920 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 364106004921 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 364106004922 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 364106004923 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 364106004924 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 364106004925 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 364106004926 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 364106004927 FeS/SAM binding site; other site 364106004928 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 364106004929 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 364106004930 Sulfatase; Region: Sulfatase; pfam00884 364106004931 transcriptional regulator YdeO; Provisional; Region: PRK09940 364106004932 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106004933 putative oxidoreductase; Provisional; Region: PRK09939 364106004934 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 364106004935 putative molybdopterin cofactor binding site [chemical binding]; other site 364106004936 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 364106004937 putative molybdopterin cofactor binding site; other site 364106004938 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 364106004939 mannosyl binding site [chemical binding]; other site 364106004940 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 364106004941 PapC N-terminal domain; Region: PapC_N; pfam13954 364106004942 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 364106004943 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 364106004944 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 364106004945 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 364106004946 Fimbrial protein; Region: Fimbrial; cl01416 364106004947 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 364106004948 NADH(P)-binding; Region: NAD_binding_10; pfam13460 364106004949 NAD(P) binding site [chemical binding]; other site 364106004950 putative active site [active] 364106004951 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 364106004952 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 364106004953 Zonular occludens toxin (Zot); Region: Zot; cl17485 364106004954 Phage replication protein CRI; Region: Phage_CRI; pfam05144 364106004955 phage/plasmid replication protein, gene II/X family; Region: rep_II_X; TIGR01629 364106004956 Phage X family; Region: Phage_X; pfam05155 364106004957 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 364106004958 non-specific DNA binding site [nucleotide binding]; other site 364106004959 salt bridge; other site 364106004960 sequence-specific DNA binding site [nucleotide binding]; other site 364106004961 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 364106004962 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 364106004963 non-specific DNA binding site [nucleotide binding]; other site 364106004964 salt bridge; other site 364106004965 sequence-specific DNA binding site [nucleotide binding]; other site 364106004966 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 364106004967 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106004968 S-adenosylmethionine binding site [chemical binding]; other site 364106004969 Predicted membrane protein [Function unknown]; Region: COG3781 364106004970 altronate oxidoreductase; Provisional; Region: PRK03643 364106004971 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 364106004972 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 364106004973 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 364106004974 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 364106004975 metal binding site [ion binding]; metal-binding site 364106004976 active site 364106004977 I-site; other site 364106004978 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 364106004979 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 364106004980 glutaminase; Provisional; Region: PRK00971 364106004981 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 364106004982 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 364106004983 NAD(P) binding site [chemical binding]; other site 364106004984 catalytic residues [active] 364106004985 Transcriptional regulator [Transcription]; Region: LysR; COG0583 364106004986 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106004987 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 364106004988 putative dimerization interface [polypeptide binding]; other site 364106004989 putative arabinose transporter; Provisional; Region: PRK03545 364106004990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106004991 putative substrate translocation pore; other site 364106004992 inner membrane protein; Provisional; Region: PRK10995 364106004993 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 364106004994 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 364106004995 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 364106004996 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106004997 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106004998 hypothetical protein; Provisional; Region: PRK10106 364106004999 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 364106005000 beta-galactosidase; Region: BGL; TIGR03356 364106005001 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 364106005002 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 364106005003 trimer interface; other site 364106005004 sugar binding site [chemical binding]; other site 364106005005 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 364106005006 active site 364106005007 methionine cluster; other site 364106005008 phosphorylation site [posttranslational modification] 364106005009 metal binding site [ion binding]; metal-binding site 364106005010 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 364106005011 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 364106005012 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 364106005013 active site 364106005014 P-loop; other site 364106005015 phosphorylation site [posttranslational modification] 364106005016 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 364106005017 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 364106005018 DNA-binding site [nucleotide binding]; DNA binding site 364106005019 UTRA domain; Region: UTRA; pfam07702 364106005020 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 364106005021 EamA-like transporter family; Region: EamA; pfam00892 364106005022 EamA-like transporter family; Region: EamA; pfam00892 364106005023 putative transporter; Provisional; Region: PRK10054 364106005024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106005025 putative substrate translocation pore; other site 364106005026 diguanylate cyclase; Provisional; Region: PRK09894 364106005027 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 364106005028 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 364106005029 metal binding site [ion binding]; metal-binding site 364106005030 active site 364106005031 I-site; other site 364106005032 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 364106005033 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 364106005034 active site 364106005035 Zn binding site [ion binding]; other site 364106005036 malonic semialdehyde reductase; Provisional; Region: PRK10538 364106005037 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 364106005038 putative NAD(P) binding site [chemical binding]; other site 364106005039 homodimer interface [polypeptide binding]; other site 364106005040 homotetramer interface [polypeptide binding]; other site 364106005041 active site 364106005042 Transcriptional regulators [Transcription]; Region: GntR; COG1802 364106005043 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 364106005044 DNA-binding site [nucleotide binding]; DNA binding site 364106005045 FCD domain; Region: FCD; pfam07729 364106005046 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 364106005047 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 364106005048 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 364106005049 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 364106005050 putative oxidoreductase; Provisional; Region: PRK10083 364106005051 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 364106005052 putative NAD(P) binding site [chemical binding]; other site 364106005053 catalytic Zn binding site [ion binding]; other site 364106005054 structural Zn binding site [ion binding]; other site 364106005055 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 364106005056 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 364106005057 putative active site pocket [active] 364106005058 putative metal binding site [ion binding]; other site 364106005059 hypothetical protein; Provisional; Region: PRK02237 364106005060 hypothetical protein; Provisional; Region: PRK13659 364106005061 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 364106005062 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 364106005063 Coenzyme A binding pocket [chemical binding]; other site 364106005064 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 364106005065 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 364106005066 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 364106005067 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 364106005068 putative [Fe4-S4] binding site [ion binding]; other site 364106005069 putative molybdopterin cofactor binding site [chemical binding]; other site 364106005070 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 364106005071 putative molybdopterin cofactor binding site; other site 364106005072 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 364106005073 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 364106005074 putative [Fe4-S4] binding site [ion binding]; other site 364106005075 putative molybdopterin cofactor binding site [chemical binding]; other site 364106005076 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 364106005077 putative molybdopterin cofactor binding site; other site 364106005078 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 364106005079 4Fe-4S binding domain; Region: Fer4; cl02805 364106005080 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 364106005081 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 364106005082 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 364106005083 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 364106005084 Cl- selectivity filter; other site 364106005085 Cl- binding residues [ion binding]; other site 364106005086 pore gating glutamate residue; other site 364106005087 dimer interface [polypeptide binding]; other site 364106005088 putative dithiobiotin synthetase; Provisional; Region: PRK12374 364106005089 AAA domain; Region: AAA_26; pfam13500 364106005090 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 364106005091 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 364106005092 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 364106005093 nucleotide binding site [chemical binding]; other site 364106005094 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 364106005095 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106005096 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 364106005097 dimerization interface [polypeptide binding]; other site 364106005098 substrate binding pocket [chemical binding]; other site 364106005099 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 364106005100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106005101 putative substrate translocation pore; other site 364106005102 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 364106005103 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 364106005104 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 364106005105 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 364106005106 Domain of unknown function DUF20; Region: UPF0118; pfam01594 364106005107 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 364106005108 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 364106005109 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 364106005110 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 364106005111 ligand binding site [chemical binding]; other site 364106005112 homodimer interface [polypeptide binding]; other site 364106005113 NAD(P) binding site [chemical binding]; other site 364106005114 trimer interface B [polypeptide binding]; other site 364106005115 trimer interface A [polypeptide binding]; other site 364106005116 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 364106005117 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 364106005118 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 364106005119 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 364106005120 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 364106005121 Spore germination protein; Region: Spore_permease; cl17796 364106005122 dihydromonapterin reductase; Provisional; Region: PRK06483 364106005123 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 364106005124 NADP binding site [chemical binding]; other site 364106005125 substrate binding pocket [chemical binding]; other site 364106005126 active site 364106005127 GlpM protein; Region: GlpM; pfam06942 364106005128 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 364106005129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106005130 active site 364106005131 phosphorylation site [posttranslational modification] 364106005132 intermolecular recognition site; other site 364106005133 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 364106005134 DNA binding site [nucleotide binding] 364106005135 sensor protein RstB; Provisional; Region: PRK10604 364106005136 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 364106005137 dimerization interface [polypeptide binding]; other site 364106005138 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 364106005139 dimer interface [polypeptide binding]; other site 364106005140 phosphorylation site [posttranslational modification] 364106005141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106005142 ATP binding site [chemical binding]; other site 364106005143 Mg2+ binding site [ion binding]; other site 364106005144 G-X-G motif; other site 364106005145 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 364106005146 fumarate hydratase; Reviewed; Region: fumC; PRK00485 364106005147 Class II fumarases; Region: Fumarase_classII; cd01362 364106005148 active site 364106005149 tetramer interface [polypeptide binding]; other site 364106005150 fumarate hydratase; Provisional; Region: PRK15389 364106005151 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 364106005152 Fumarase C-terminus; Region: Fumerase_C; pfam05683 364106005153 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 364106005154 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 364106005155 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 364106005156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 364106005157 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 364106005158 putative outer membrane porin protein; Provisional; Region: PRK11379 364106005159 glucuronide transporter; Provisional; Region: PRK09848 364106005160 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 364106005161 beta-D-glucuronidase; Provisional; Region: PRK10150 364106005162 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 364106005163 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 364106005164 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 364106005165 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 364106005166 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 364106005167 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 364106005168 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 364106005169 NAD binding site [chemical binding]; other site 364106005170 substrate binding site [chemical binding]; other site 364106005171 homotetramer interface [polypeptide binding]; other site 364106005172 homodimer interface [polypeptide binding]; other site 364106005173 active site 364106005174 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 364106005175 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 364106005176 DNA binding site [nucleotide binding] 364106005177 domain linker motif; other site 364106005178 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 364106005179 putative dimerization interface [polypeptide binding]; other site 364106005180 putative ligand binding site [chemical binding]; other site 364106005181 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 364106005182 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 364106005183 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 364106005184 active site turn [active] 364106005185 phosphorylation site [posttranslational modification] 364106005186 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 364106005187 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 364106005188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106005189 homodimer interface [polypeptide binding]; other site 364106005190 catalytic residue [active] 364106005191 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 364106005192 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 364106005193 active site 364106005194 purine riboside binding site [chemical binding]; other site 364106005195 putative oxidoreductase; Provisional; Region: PRK11579 364106005196 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 364106005197 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 364106005198 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 364106005199 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 364106005200 electron transport complex protein RsxA; Provisional; Region: PRK05151 364106005201 electron transport complex protein RnfB; Provisional; Region: PRK05113 364106005202 Putative Fe-S cluster; Region: FeS; pfam04060 364106005203 4Fe-4S binding domain; Region: Fer4; pfam00037 364106005204 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 364106005205 SLBB domain; Region: SLBB; pfam10531 364106005206 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 364106005207 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 364106005208 electron transport complex protein RnfG; Validated; Region: PRK01908 364106005209 electron transport complex RsxE subunit; Provisional; Region: PRK12405 364106005210 endonuclease III; Provisional; Region: PRK10702 364106005211 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 364106005212 minor groove reading motif; other site 364106005213 helix-hairpin-helix signature motif; other site 364106005214 substrate binding pocket [chemical binding]; other site 364106005215 active site 364106005216 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 364106005217 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 364106005218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106005219 putative substrate translocation pore; other site 364106005220 POT family; Region: PTR2; pfam00854 364106005221 glutathionine S-transferase; Provisional; Region: PRK10542 364106005222 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 364106005223 C-terminal domain interface [polypeptide binding]; other site 364106005224 GSH binding site (G-site) [chemical binding]; other site 364106005225 dimer interface [polypeptide binding]; other site 364106005226 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 364106005227 N-terminal domain interface [polypeptide binding]; other site 364106005228 dimer interface [polypeptide binding]; other site 364106005229 substrate binding pocket (H-site) [chemical binding]; other site 364106005230 pyridoxamine kinase; Validated; Region: PRK05756 364106005231 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 364106005232 dimer interface [polypeptide binding]; other site 364106005233 pyridoxal binding site [chemical binding]; other site 364106005234 ATP binding site [chemical binding]; other site 364106005235 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 364106005236 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 364106005237 active site 364106005238 HIGH motif; other site 364106005239 dimer interface [polypeptide binding]; other site 364106005240 KMSKS motif; other site 364106005241 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 364106005242 RNA binding surface [nucleotide binding]; other site 364106005243 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 364106005244 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 364106005245 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 364106005246 lysozyme inhibitor; Provisional; Region: PRK11372 364106005247 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 364106005248 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 364106005249 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 364106005250 transcriptional regulator SlyA; Provisional; Region: PRK03573 364106005251 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 364106005252 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 364106005253 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 364106005254 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 364106005255 HlyD family secretion protein; Region: HlyD_3; pfam13437 364106005256 Fusaric acid resistance protein family; Region: FUSC; pfam04632 364106005257 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 364106005258 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 364106005259 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 364106005260 E-class dimer interface [polypeptide binding]; other site 364106005261 P-class dimer interface [polypeptide binding]; other site 364106005262 active site 364106005263 Cu2+ binding site [ion binding]; other site 364106005264 Zn2+ binding site [ion binding]; other site 364106005265 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 364106005266 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 364106005267 active site 364106005268 catalytic tetrad [active] 364106005269 Predicted Fe-S protein [General function prediction only]; Region: COG3313 364106005270 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 364106005271 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 364106005272 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 364106005273 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 364106005274 FMN binding site [chemical binding]; other site 364106005275 active site 364106005276 substrate binding site [chemical binding]; other site 364106005277 catalytic residue [active] 364106005278 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 364106005279 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 364106005280 dimer interface [polypeptide binding]; other site 364106005281 active site 364106005282 metal binding site [ion binding]; metal-binding site 364106005283 glutathione binding site [chemical binding]; other site 364106005284 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 364106005285 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 364106005286 dimer interface [polypeptide binding]; other site 364106005287 catalytic site [active] 364106005288 putative active site [active] 364106005289 putative substrate binding site [chemical binding]; other site 364106005290 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 364106005291 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 364106005292 putative GSH binding site [chemical binding]; other site 364106005293 catalytic residues [active] 364106005294 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 364106005295 NlpC/P60 family; Region: NLPC_P60; pfam00877 364106005296 superoxide dismutase; Provisional; Region: PRK10543 364106005297 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 364106005298 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 364106005299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106005300 Major Facilitator Superfamily; Region: MFS_1; pfam07690 364106005301 putative substrate translocation pore; other site 364106005302 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 364106005303 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 364106005304 DNA binding site [nucleotide binding] 364106005305 domain linker motif; other site 364106005306 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 364106005307 dimerization interface [polypeptide binding]; other site 364106005308 ligand binding site [chemical binding]; other site 364106005309 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 364106005310 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106005311 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 364106005312 dimerization interface [polypeptide binding]; other site 364106005313 putative transporter; Provisional; Region: PRK11043 364106005314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106005315 putative substrate translocation pore; other site 364106005316 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 364106005317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 364106005318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106005319 S-adenosylmethionine binding site [chemical binding]; other site 364106005320 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 364106005321 Lumazine binding domain; Region: Lum_binding; pfam00677 364106005322 Lumazine binding domain; Region: Lum_binding; pfam00677 364106005323 multidrug efflux protein; Reviewed; Region: PRK01766 364106005324 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 364106005325 cation binding site [ion binding]; other site 364106005326 hypothetical protein; Provisional; Region: PRK09945 364106005327 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 364106005328 putative monooxygenase; Provisional; Region: PRK11118 364106005329 hypothetical protein; Provisional; Region: PRK09897 364106005330 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 364106005331 hypothetical protein; Provisional; Region: PRK09946 364106005332 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 364106005333 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 364106005334 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 364106005335 hypothetical protein; Provisional; Region: PRK09947 364106005336 putative oxidoreductase; Provisional; Region: PRK09849 364106005337 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 364106005338 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 364106005339 hypothetical protein; Provisional; Region: PRK09898 364106005340 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 364106005341 hypothetical protein; Provisional; Region: PRK10292 364106005342 pyruvate kinase; Provisional; Region: PRK09206 364106005343 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 364106005344 active site 364106005345 domain interfaces; other site 364106005346 murein lipoprotein; Provisional; Region: PRK15396 364106005347 L,D-transpeptidase; Provisional; Region: PRK10190 364106005348 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 364106005349 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 364106005350 cysteine desufuration protein SufE; Provisional; Region: PRK09296 364106005351 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 364106005352 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 364106005353 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 364106005354 catalytic residue [active] 364106005355 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 364106005356 FeS assembly protein SufD; Region: sufD; TIGR01981 364106005357 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 364106005358 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 364106005359 Walker A/P-loop; other site 364106005360 ATP binding site [chemical binding]; other site 364106005361 Q-loop/lid; other site 364106005362 ABC transporter signature motif; other site 364106005363 Walker B; other site 364106005364 D-loop; other site 364106005365 H-loop/switch region; other site 364106005366 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 364106005367 putative ABC transporter; Region: ycf24; CHL00085 364106005368 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 364106005369 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 364106005370 CoenzymeA binding site [chemical binding]; other site 364106005371 subunit interaction site [polypeptide binding]; other site 364106005372 PHB binding site; other site 364106005373 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 364106005374 FAD binding domain; Region: FAD_binding_4; pfam01565 364106005375 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 364106005376 putative inner membrane protein; Provisional; Region: PRK10983 364106005377 Domain of unknown function DUF20; Region: UPF0118; pfam01594 364106005378 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 364106005379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106005380 Major Facilitator Superfamily; Region: MFS_1; pfam07690 364106005381 putative substrate translocation pore; other site 364106005382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106005383 putative substrate translocation pore; other site 364106005384 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 364106005385 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 364106005386 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 364106005387 shikimate binding site; other site 364106005388 NAD(P) binding site [chemical binding]; other site 364106005389 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 364106005390 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 364106005391 active site 364106005392 catalytic residue [active] 364106005393 dimer interface [polypeptide binding]; other site 364106005394 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 364106005395 Coenzyme A transferase; Region: CoA_trans; smart00882 364106005396 Coenzyme A transferase; Region: CoA_trans; cl17247 364106005397 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 364106005398 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 364106005399 active site 364106005400 Cupin domain; Region: Cupin_2; pfam07883 364106005401 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 364106005402 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 364106005403 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106005404 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 364106005405 Ligand binding site [chemical binding]; other site 364106005406 Electron transfer flavoprotein domain; Region: ETF; pfam01012 364106005407 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 364106005408 Electron transfer flavoprotein domain; Region: ETF; smart00893 364106005409 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 364106005410 oxidoreductase; Provisional; Region: PRK10015 364106005411 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 364106005412 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 364106005413 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 364106005414 acyl-activating enzyme (AAE) consensus motif; other site 364106005415 putative AMP binding site [chemical binding]; other site 364106005416 putative active site [active] 364106005417 putative CoA binding site [chemical binding]; other site 364106005418 phosphoenolpyruvate synthase; Validated; Region: PRK06464 364106005419 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 364106005420 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 364106005421 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 364106005422 PEP synthetase regulatory protein; Provisional; Region: PRK05339 364106005423 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 364106005424 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 364106005425 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 364106005426 Uncharacterized conserved protein [Function unknown]; Region: COG0397 364106005427 hypothetical protein; Validated; Region: PRK00029 364106005428 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 364106005429 NlpC/P60 family; Region: NLPC_P60; pfam00877 364106005430 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 364106005431 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 364106005432 Walker A/P-loop; other site 364106005433 ATP binding site [chemical binding]; other site 364106005434 Q-loop/lid; other site 364106005435 ABC transporter signature motif; other site 364106005436 Walker B; other site 364106005437 D-loop; other site 364106005438 H-loop/switch region; other site 364106005439 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 364106005440 catalytic residues [active] 364106005441 dimer interface [polypeptide binding]; other site 364106005442 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 364106005443 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 364106005444 ABC-ATPase subunit interface; other site 364106005445 dimer interface [polypeptide binding]; other site 364106005446 putative PBP binding regions; other site 364106005447 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 364106005448 IHF dimer interface [polypeptide binding]; other site 364106005449 IHF - DNA interface [nucleotide binding]; other site 364106005450 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 364106005451 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 364106005452 putative tRNA-binding site [nucleotide binding]; other site 364106005453 B3/4 domain; Region: B3_4; pfam03483 364106005454 tRNA synthetase B5 domain; Region: B5; smart00874 364106005455 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 364106005456 dimer interface [polypeptide binding]; other site 364106005457 motif 1; other site 364106005458 motif 3; other site 364106005459 motif 2; other site 364106005460 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 364106005461 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 364106005462 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 364106005463 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 364106005464 dimer interface [polypeptide binding]; other site 364106005465 motif 1; other site 364106005466 active site 364106005467 motif 2; other site 364106005468 motif 3; other site 364106005469 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 364106005470 23S rRNA binding site [nucleotide binding]; other site 364106005471 L21 binding site [polypeptide binding]; other site 364106005472 L13 binding site [polypeptide binding]; other site 364106005473 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 364106005474 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 364106005475 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 364106005476 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 364106005477 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 364106005478 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 364106005479 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 364106005480 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 364106005481 active site 364106005482 dimer interface [polypeptide binding]; other site 364106005483 motif 1; other site 364106005484 motif 2; other site 364106005485 motif 3; other site 364106005486 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 364106005487 anticodon binding site; other site 364106005488 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 364106005489 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 364106005490 6-phosphofructokinase 2; Provisional; Region: PRK10294 364106005491 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 364106005492 putative substrate binding site [chemical binding]; other site 364106005493 putative ATP binding site [chemical binding]; other site 364106005494 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 364106005495 Phosphotransferase enzyme family; Region: APH; pfam01636 364106005496 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 364106005497 active site 364106005498 ATP binding site [chemical binding]; other site 364106005499 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 364106005500 YniB-like protein; Region: YniB; pfam14002 364106005501 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 364106005502 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 364106005503 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 364106005504 motif II; other site 364106005505 inner membrane protein; Provisional; Region: PRK11648 364106005506 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 364106005507 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 364106005508 cell division modulator; Provisional; Region: PRK10113 364106005509 hydroperoxidase II; Provisional; Region: katE; PRK11249 364106005510 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 364106005511 tetramer interface [polypeptide binding]; other site 364106005512 heme binding pocket [chemical binding]; other site 364106005513 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 364106005514 domain interactions; other site 364106005515 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 364106005516 putative active site [active] 364106005517 YdjC motif; other site 364106005518 Mg binding site [ion binding]; other site 364106005519 putative homodimer interface [polypeptide binding]; other site 364106005520 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 364106005521 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 364106005522 NAD binding site [chemical binding]; other site 364106005523 sugar binding site [chemical binding]; other site 364106005524 divalent metal binding site [ion binding]; other site 364106005525 tetramer (dimer of dimers) interface [polypeptide binding]; other site 364106005526 dimer interface [polypeptide binding]; other site 364106005527 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 364106005528 Cupin domain; Region: Cupin_2; pfam07883 364106005529 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106005530 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 364106005531 methionine cluster; other site 364106005532 active site 364106005533 phosphorylation site [posttranslational modification] 364106005534 metal binding site [ion binding]; metal-binding site 364106005535 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 364106005536 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 364106005537 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 364106005538 active site 364106005539 P-loop; other site 364106005540 phosphorylation site [posttranslational modification] 364106005541 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 364106005542 NAD+ synthetase; Region: nadE; TIGR00552 364106005543 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 364106005544 homodimer interface [polypeptide binding]; other site 364106005545 NAD binding pocket [chemical binding]; other site 364106005546 ATP binding pocket [chemical binding]; other site 364106005547 Mg binding site [ion binding]; other site 364106005548 active-site loop [active] 364106005549 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 364106005550 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 364106005551 GIY-YIG motif/motif A; other site 364106005552 active site 364106005553 catalytic site [active] 364106005554 putative DNA binding site [nucleotide binding]; other site 364106005555 metal binding site [ion binding]; metal-binding site 364106005556 hypothetical protein; Provisional; Region: PRK11396 364106005557 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 364106005558 dimer interface [polypeptide binding]; other site 364106005559 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 364106005560 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 364106005561 putative active site [active] 364106005562 Zn binding site [ion binding]; other site 364106005563 succinylarginine dihydrolase; Provisional; Region: PRK13281 364106005564 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 364106005565 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 364106005566 NAD(P) binding site [chemical binding]; other site 364106005567 catalytic residues [active] 364106005568 arginine succinyltransferase; Provisional; Region: PRK10456 364106005569 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 364106005570 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 364106005571 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 364106005572 inhibitor-cofactor binding pocket; inhibition site 364106005573 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106005574 catalytic residue [active] 364106005575 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 364106005576 putative catalytic site [active] 364106005577 putative phosphate binding site [ion binding]; other site 364106005578 active site 364106005579 metal binding site A [ion binding]; metal-binding site 364106005580 DNA binding site [nucleotide binding] 364106005581 putative AP binding site [nucleotide binding]; other site 364106005582 putative metal binding site B [ion binding]; other site 364106005583 Uncharacterized conserved protein [Function unknown]; Region: COG0398 364106005584 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 364106005585 Uncharacterized conserved protein [Function unknown]; Region: COG0398 364106005586 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 364106005587 Uncharacterized conserved protein [Function unknown]; Region: COG2128 364106005588 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 364106005589 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 364106005590 hypothetical protein; Provisional; Region: PRK11622 364106005591 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 364106005592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106005593 dimer interface [polypeptide binding]; other site 364106005594 conserved gate region; other site 364106005595 putative PBP binding loops; other site 364106005596 ABC-ATPase subunit interface; other site 364106005597 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 364106005598 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 364106005599 Walker A/P-loop; other site 364106005600 ATP binding site [chemical binding]; other site 364106005601 Q-loop/lid; other site 364106005602 ABC transporter signature motif; other site 364106005603 Walker B; other site 364106005604 D-loop; other site 364106005605 H-loop/switch region; other site 364106005606 Rhodanese Homology Domain; Region: RHOD; smart00450 364106005607 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 364106005608 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 364106005609 active site residue [active] 364106005610 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 364106005611 active site residue [active] 364106005612 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 364106005613 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 364106005614 active site 364106005615 8-oxo-dGMP binding site [chemical binding]; other site 364106005616 nudix motif; other site 364106005617 metal binding site [ion binding]; metal-binding site 364106005618 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 364106005619 glutamate dehydrogenase; Provisional; Region: PRK09414 364106005620 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 364106005621 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 364106005622 NAD(P) binding site [chemical binding]; other site 364106005623 DNA topoisomerase III; Provisional; Region: PRK07726 364106005624 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 364106005625 active site 364106005626 putative interdomain interaction site [polypeptide binding]; other site 364106005627 putative metal-binding site [ion binding]; other site 364106005628 putative nucleotide binding site [chemical binding]; other site 364106005629 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 364106005630 domain I; other site 364106005631 DNA binding groove [nucleotide binding] 364106005632 phosphate binding site [ion binding]; other site 364106005633 domain II; other site 364106005634 domain III; other site 364106005635 nucleotide binding site [chemical binding]; other site 364106005636 catalytic site [active] 364106005637 domain IV; other site 364106005638 selenophosphate synthetase; Provisional; Region: PRK00943 364106005639 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 364106005640 dimerization interface [polypeptide binding]; other site 364106005641 putative ATP binding site [chemical binding]; other site 364106005642 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 364106005643 putative FMN binding site [chemical binding]; other site 364106005644 protease 4; Provisional; Region: PRK10949 364106005645 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 364106005646 tandem repeat interface [polypeptide binding]; other site 364106005647 oligomer interface [polypeptide binding]; other site 364106005648 active site residues [active] 364106005649 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 364106005650 tandem repeat interface [polypeptide binding]; other site 364106005651 oligomer interface [polypeptide binding]; other site 364106005652 active site residues [active] 364106005653 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 364106005654 active site 364106005655 homodimer interface [polypeptide binding]; other site 364106005656 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 364106005657 Isochorismatase family; Region: Isochorismatase; pfam00857 364106005658 catalytic triad [active] 364106005659 metal binding site [ion binding]; metal-binding site 364106005660 conserved cis-peptide bond; other site 364106005661 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 364106005662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106005663 putative substrate translocation pore; other site 364106005664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106005665 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 364106005666 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 364106005667 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 364106005668 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 364106005669 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 364106005670 active site 364106005671 catalytic tetrad [active] 364106005672 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 364106005673 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 364106005674 substrate binding site [chemical binding]; other site 364106005675 ATP binding site [chemical binding]; other site 364106005676 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 364106005677 intersubunit interface [polypeptide binding]; other site 364106005678 active site 364106005679 zinc binding site [ion binding]; other site 364106005680 Na+ binding site [ion binding]; other site 364106005681 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 364106005682 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 364106005683 inhibitor binding site; inhibition site 364106005684 catalytic Zn binding site [ion binding]; other site 364106005685 structural Zn binding site [ion binding]; other site 364106005686 NADP binding site [chemical binding]; other site 364106005687 tetramer interface [polypeptide binding]; other site 364106005688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106005689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106005690 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 364106005691 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 364106005692 putative NAD(P) binding site [chemical binding]; other site 364106005693 catalytic Zn binding site [ion binding]; other site 364106005694 structural Zn binding site [ion binding]; other site 364106005695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 364106005696 methionine sulfoxide reductase B; Provisional; Region: PRK00222 364106005697 SelR domain; Region: SelR; pfam01641 364106005698 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 364106005699 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 364106005700 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 364106005701 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 364106005702 active site 364106005703 phosphate binding residues; other site 364106005704 catalytic residues [active] 364106005705 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 364106005706 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 364106005707 active site 364106005708 catalytic tetrad [active] 364106005709 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 364106005710 PrkA family serine protein kinase; Provisional; Region: PRK15455 364106005711 AAA ATPase domain; Region: AAA_16; pfam13191 364106005712 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 364106005713 hypothetical protein; Provisional; Region: PRK05325 364106005714 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 364106005715 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 364106005716 metal binding site [ion binding]; metal-binding site 364106005717 active site 364106005718 I-site; other site 364106005719 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 364106005720 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 364106005721 metal binding site [ion binding]; metal-binding site 364106005722 active site 364106005723 I-site; other site 364106005724 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 364106005725 putative deacylase active site [active] 364106005726 Predicted membrane protein [Function unknown]; Region: COG2707 364106005727 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 364106005728 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106005729 cyanate transporter; Region: CynX; TIGR00896 364106005730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106005731 Uncharacterized conserved protein [Function unknown]; Region: COG3189 364106005732 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 364106005733 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 364106005734 Domain of unknown function (DUF333); Region: DUF333; pfam03891 364106005735 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 364106005736 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 364106005737 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 364106005738 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 364106005739 metal binding site [ion binding]; metal-binding site 364106005740 active site 364106005741 I-site; other site 364106005742 hypothetical protein; Provisional; Region: PRK10457 364106005743 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 364106005744 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 364106005745 leucine export protein LeuE; Provisional; Region: PRK10958 364106005746 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 364106005747 ribonuclease D; Provisional; Region: PRK10829 364106005748 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 364106005749 catalytic site [active] 364106005750 putative active site [active] 364106005751 putative substrate binding site [chemical binding]; other site 364106005752 Helicase and RNase D C-terminal; Region: HRDC; smart00341 364106005753 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 364106005754 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 364106005755 acyl-activating enzyme (AAE) consensus motif; other site 364106005756 putative AMP binding site [chemical binding]; other site 364106005757 putative active site [active] 364106005758 putative CoA binding site [chemical binding]; other site 364106005759 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 364106005760 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 364106005761 Glycoprotease family; Region: Peptidase_M22; pfam00814 364106005762 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 364106005763 DEAD/DEAH box helicase; Region: DEAD; pfam00270 364106005764 DEAD_2; Region: DEAD_2; pfam06733 364106005765 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 364106005766 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 364106005767 homotrimer interaction site [polypeptide binding]; other site 364106005768 putative active site [active] 364106005769 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 364106005770 hypothetical protein; Provisional; Region: PRK05114 364106005771 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 364106005772 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 364106005773 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 364106005774 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 364106005775 putative active site [active] 364106005776 putative CoA binding site [chemical binding]; other site 364106005777 nudix motif; other site 364106005778 metal binding site [ion binding]; metal-binding site 364106005779 L-serine deaminase; Provisional; Region: PRK15023 364106005780 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 364106005781 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 364106005782 phage resistance protein; Provisional; Region: PRK10551 364106005783 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 364106005784 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 364106005785 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 364106005786 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 364106005787 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 364106005788 Transporter associated domain; Region: CorC_HlyC; smart01091 364106005789 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 364106005790 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 364106005791 active pocket/dimerization site; other site 364106005792 active site 364106005793 phosphorylation site [posttranslational modification] 364106005794 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 364106005795 active site 364106005796 phosphorylation site [posttranslational modification] 364106005797 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 364106005798 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 364106005799 Predicted membrane protein [Function unknown]; Region: COG4811 364106005800 hypothetical protein; Provisional; Region: PRK11469 364106005801 Domain of unknown function DUF; Region: DUF204; pfam02659 364106005802 Domain of unknown function DUF; Region: DUF204; pfam02659 364106005803 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 364106005804 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106005805 S-adenosylmethionine binding site [chemical binding]; other site 364106005806 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 364106005807 DNA-binding site [nucleotide binding]; DNA binding site 364106005808 RNA-binding motif; other site 364106005809 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 364106005810 YebO-like protein; Region: YebO; pfam13974 364106005811 PhoPQ regulatory protein; Provisional; Region: PRK10299 364106005812 YobH-like protein; Region: YobH; pfam13996 364106005813 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 364106005814 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 364106005815 dimerization interface [polypeptide binding]; other site 364106005816 putative Zn2+ binding site [ion binding]; other site 364106005817 putative DNA binding site [nucleotide binding]; other site 364106005818 Bacterial transcriptional regulator; Region: IclR; pfam01614 364106005819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106005820 Major Facilitator Superfamily; Region: MFS_1; pfam07690 364106005821 putative substrate translocation pore; other site 364106005822 Predicted integral membrane protein [Function unknown]; Region: COG5521 364106005823 heat shock protein HtpX; Provisional; Region: PRK05457 364106005824 carboxy-terminal protease; Provisional; Region: PRK11186 364106005825 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 364106005826 protein binding site [polypeptide binding]; other site 364106005827 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 364106005828 Catalytic dyad [active] 364106005829 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 364106005830 ProP expression regulator; Provisional; Region: PRK04950 364106005831 ProQ/FINO family; Region: ProQ; pfam04352 364106005832 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 364106005833 GAF domain; Region: GAF_2; pfam13185 364106005834 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 364106005835 Paraquat-inducible protein A; Region: PqiA; pfam04403 364106005836 Paraquat-inducible protein A; Region: PqiA; pfam04403 364106005837 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 364106005838 mce related protein; Region: MCE; pfam02470 364106005839 mce related protein; Region: MCE; pfam02470 364106005840 mce related protein; Region: MCE; pfam02470 364106005841 mce related protein; Region: MCE; pfam02470 364106005842 mce related protein; Region: MCE; pfam02470 364106005843 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 364106005844 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 364106005845 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 364106005846 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 364106005847 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 364106005848 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 364106005849 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 364106005850 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 364106005851 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 364106005852 hypothetical protein; Provisional; Region: PRK10301 364106005853 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 364106005854 Predicted amidohydrolase [General function prediction only]; Region: COG0388 364106005855 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 364106005856 exodeoxyribonuclease X; Provisional; Region: PRK07983 364106005857 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 364106005858 active site 364106005859 catalytic site [active] 364106005860 substrate binding site [chemical binding]; other site 364106005861 protease 2; Provisional; Region: PRK10115 364106005862 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 364106005863 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 364106005864 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 364106005865 putative metal binding site [ion binding]; other site 364106005866 hypothetical protein; Provisional; Region: PRK13680 364106005867 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 364106005868 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 364106005869 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 364106005870 ATP-grasp domain; Region: ATP-grasp; pfam02222 364106005871 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 364106005872 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 364106005873 active site 364106005874 intersubunit interface [polypeptide binding]; other site 364106005875 catalytic residue [active] 364106005876 phosphogluconate dehydratase; Validated; Region: PRK09054 364106005877 6-phosphogluconate dehydratase; Region: edd; TIGR01196 364106005878 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 364106005879 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 364106005880 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 364106005881 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 364106005882 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 364106005883 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 364106005884 putative active site [active] 364106005885 pyruvate kinase; Provisional; Region: PRK05826 364106005886 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 364106005887 domain interfaces; other site 364106005888 active site 364106005889 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 364106005890 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 364106005891 putative acyl-acceptor binding pocket; other site 364106005892 putative peptidase; Provisional; Region: PRK11649 364106005893 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 364106005894 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 364106005895 Peptidase family M23; Region: Peptidase_M23; pfam01551 364106005896 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 364106005897 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 364106005898 metal binding site [ion binding]; metal-binding site 364106005899 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 364106005900 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 364106005901 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 364106005902 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 364106005903 ABC-ATPase subunit interface; other site 364106005904 dimer interface [polypeptide binding]; other site 364106005905 putative PBP binding regions; other site 364106005906 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 364106005907 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106005908 Walker A motif; other site 364106005909 ATP binding site [chemical binding]; other site 364106005910 Walker B motif; other site 364106005911 arginine finger; other site 364106005912 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 364106005913 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 364106005914 RuvA N terminal domain; Region: RuvA_N; pfam01330 364106005915 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 364106005916 hypothetical protein; Provisional; Region: PRK11470 364106005917 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 364106005918 active site 364106005919 putative DNA-binding cleft [nucleotide binding]; other site 364106005920 dimer interface [polypeptide binding]; other site 364106005921 hypothetical protein; Validated; Region: PRK00110 364106005922 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 364106005923 nudix motif; other site 364106005924 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 364106005925 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 364106005926 dimer interface [polypeptide binding]; other site 364106005927 anticodon binding site; other site 364106005928 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 364106005929 homodimer interface [polypeptide binding]; other site 364106005930 motif 1; other site 364106005931 active site 364106005932 motif 2; other site 364106005933 GAD domain; Region: GAD; pfam02938 364106005934 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 364106005935 motif 3; other site 364106005936 Isochorismatase family; Region: Isochorismatase; pfam00857 364106005937 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 364106005938 catalytic triad [active] 364106005939 conserved cis-peptide bond; other site 364106005940 hypothetical protein; Provisional; Region: PRK10302 364106005941 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 364106005942 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106005943 S-adenosylmethionine binding site [chemical binding]; other site 364106005944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106005945 S-adenosylmethionine binding site [chemical binding]; other site 364106005946 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 364106005947 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 364106005948 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 364106005949 molybdopterin cofactor binding site [chemical binding]; other site 364106005950 substrate binding site [chemical binding]; other site 364106005951 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 364106005952 molybdopterin cofactor binding site; other site 364106005953 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 364106005954 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 364106005955 copper homeostasis protein CutC; Provisional; Region: PRK11572 364106005956 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 364106005957 putative metal binding site [ion binding]; other site 364106005958 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 364106005959 arginyl-tRNA synthetase; Region: argS; TIGR00456 364106005960 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 364106005961 active site 364106005962 HIGH motif; other site 364106005963 KMSK motif region; other site 364106005964 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 364106005965 tRNA binding surface [nucleotide binding]; other site 364106005966 anticodon binding site; other site 364106005967 Flagellar protein FlhE; Region: FlhE; pfam06366 364106005968 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 364106005969 FHIPEP family; Region: FHIPEP; pfam00771 364106005970 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 364106005971 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 364106005972 chemotaxis regulator CheZ; Provisional; Region: PRK11166 364106005973 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 364106005974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106005975 active site 364106005976 phosphorylation site [posttranslational modification] 364106005977 intermolecular recognition site; other site 364106005978 dimerization interface [polypeptide binding]; other site 364106005979 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 364106005980 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106005981 active site 364106005982 phosphorylation site [posttranslational modification] 364106005983 intermolecular recognition site; other site 364106005984 dimerization interface [polypeptide binding]; other site 364106005985 CheB methylesterase; Region: CheB_methylest; pfam01339 364106005986 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 364106005987 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 364106005988 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106005989 S-adenosylmethionine binding site [chemical binding]; other site 364106005990 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 364106005991 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 364106005992 dimer interface [polypeptide binding]; other site 364106005993 ligand binding site [chemical binding]; other site 364106005994 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 364106005995 dimerization interface [polypeptide binding]; other site 364106005996 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 364106005997 dimer interface [polypeptide binding]; other site 364106005998 putative CheW interface [polypeptide binding]; other site 364106005999 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 364106006000 putative CheA interaction surface; other site 364106006001 chemotaxis protein CheA; Provisional; Region: PRK10547 364106006002 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 364106006003 putative binding surface; other site 364106006004 active site 364106006005 CheY binding; Region: CheY-binding; pfam09078 364106006006 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 364106006007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106006008 ATP binding site [chemical binding]; other site 364106006009 Mg2+ binding site [ion binding]; other site 364106006010 G-X-G motif; other site 364106006011 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 364106006012 flagellar motor protein MotB; Validated; Region: motB; PRK09041 364106006013 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 364106006014 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 364106006015 ligand binding site [chemical binding]; other site 364106006016 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 364106006017 flagellar motor protein MotA; Validated; Region: PRK09110 364106006018 transcriptional activator FlhC; Provisional; Region: PRK12722 364106006019 transcriptional activator FlhD; Provisional; Region: PRK02909 364106006020 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 364106006021 Ligand Binding Site [chemical binding]; other site 364106006022 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 364106006023 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 364106006024 active site 364106006025 homotetramer interface [polypeptide binding]; other site 364106006026 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 364106006027 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 364106006028 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 364106006029 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 364106006030 TM-ABC transporter signature motif; other site 364106006031 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 364106006032 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 364106006033 Walker A/P-loop; other site 364106006034 ATP binding site [chemical binding]; other site 364106006035 Q-loop/lid; other site 364106006036 ABC transporter signature motif; other site 364106006037 Walker B; other site 364106006038 D-loop; other site 364106006039 H-loop/switch region; other site 364106006040 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 364106006041 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 364106006042 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 364106006043 ligand binding site [chemical binding]; other site 364106006044 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 364106006045 Ferritin-like domain; Region: Ferritin; pfam00210 364106006046 ferroxidase diiron center [ion binding]; other site 364106006047 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 364106006048 YecR-like lipoprotein; Region: YecR; pfam13992 364106006049 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 364106006050 Ferritin-like domain; Region: Ferritin; pfam00210 364106006051 ferroxidase diiron center [ion binding]; other site 364106006052 probable metal-binding protein; Region: matur_matur; TIGR03853 364106006053 tyrosine transporter TyrP; Provisional; Region: PRK15132 364106006054 aromatic amino acid transport protein; Region: araaP; TIGR00837 364106006055 hypothetical protein; Provisional; Region: PRK10396 364106006056 yecA family protein; Region: ygfB_yecA; TIGR02292 364106006057 SEC-C motif; Region: SEC-C; pfam02810 364106006058 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 364106006059 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 364106006060 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 364106006061 GIY-YIG motif/motif A; other site 364106006062 active site 364106006063 catalytic site [active] 364106006064 putative DNA binding site [nucleotide binding]; other site 364106006065 metal binding site [ion binding]; metal-binding site 364106006066 UvrB/uvrC motif; Region: UVR; pfam02151 364106006067 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 364106006068 Helix-hairpin-helix motif; Region: HHH; pfam00633 364106006069 response regulator; Provisional; Region: PRK09483 364106006070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106006071 active site 364106006072 phosphorylation site [posttranslational modification] 364106006073 intermolecular recognition site; other site 364106006074 dimerization interface [polypeptide binding]; other site 364106006075 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 364106006076 DNA binding residues [nucleotide binding] 364106006077 dimerization interface [polypeptide binding]; other site 364106006078 hypothetical protein; Provisional; Region: PRK10613 364106006079 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 364106006080 Autoinducer binding domain; Region: Autoind_bind; pfam03472 364106006081 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 364106006082 DNA binding residues [nucleotide binding] 364106006083 dimerization interface [polypeptide binding]; other site 364106006084 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 364106006085 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 364106006086 Walker A/P-loop; other site 364106006087 ATP binding site [chemical binding]; other site 364106006088 Q-loop/lid; other site 364106006089 ABC transporter signature motif; other site 364106006090 Walker B; other site 364106006091 D-loop; other site 364106006092 H-loop/switch region; other site 364106006093 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 364106006094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106006095 dimer interface [polypeptide binding]; other site 364106006096 conserved gate region; other site 364106006097 putative PBP binding loops; other site 364106006098 ABC-ATPase subunit interface; other site 364106006099 D-cysteine desulfhydrase; Validated; Region: PRK03910 364106006100 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 364106006101 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106006102 catalytic residue [active] 364106006103 cystine transporter subunit; Provisional; Region: PRK11260 364106006104 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 364106006105 substrate binding pocket [chemical binding]; other site 364106006106 membrane-bound complex binding site; other site 364106006107 hinge residues; other site 364106006108 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 364106006109 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 364106006110 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 364106006111 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 364106006112 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 364106006113 DNA binding residues [nucleotide binding] 364106006114 flagellin; Validated; Region: PRK08026 364106006115 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 364106006116 Flagellin protein; Region: FliC; pfam12445 364106006117 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 364106006118 flagellar capping protein; Reviewed; Region: fliD; PRK08032 364106006119 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 364106006120 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 364106006121 Flagellar protein FliS; Region: FliS; cl00654 364106006122 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 364106006123 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 364106006124 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 364106006125 active site 364106006126 Na/Ca binding site [ion binding]; other site 364106006127 catalytic site [active] 364106006128 lipoprotein; Provisional; Region: PRK10397 364106006129 putative inner membrane protein; Provisional; Region: PRK11099 364106006130 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 364106006131 CPxP motif; other site 364106006132 hypothetical protein; Provisional; Region: PRK09951 364106006133 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 364106006134 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 364106006135 trimer interface [polypeptide binding]; other site 364106006136 eyelet of channel; other site 364106006137 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 364106006138 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 364106006139 substrate binding site [chemical binding]; other site 364106006140 multidrug efflux protein; Reviewed; Region: emrE; PRK09541 364106006141 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 364106006142 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 364106006143 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 364106006144 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 364106006145 flagellar motor switch protein FliG; Region: fliG; TIGR00207 364106006146 FliG C-terminal domain; Region: FliG_C; pfam01706 364106006147 flagellar assembly protein H; Validated; Region: fliH; PRK05687 364106006148 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 364106006149 Flagellar assembly protein FliH; Region: FliH; pfam02108 364106006150 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 364106006151 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 364106006152 Walker A motif/ATP binding site; other site 364106006153 Walker B motif; other site 364106006154 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 364106006155 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 364106006156 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 364106006157 flagellar hook-length control protein; Provisional; Region: PRK10118 364106006158 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 364106006159 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 364106006160 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 364106006161 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 364106006162 flagellar motor switch protein; Validated; Region: fliN; PRK05698 364106006163 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 364106006164 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 364106006165 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 364106006166 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 364106006167 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 364106006168 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 364106006169 DNA binding residues [nucleotide binding] 364106006170 dimerization interface [polypeptide binding]; other site 364106006171 hypothetical protein; Provisional; Region: PRK10708 364106006172 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 364106006173 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 364106006174 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 364106006175 active site 364106006176 motif I; other site 364106006177 motif II; other site 364106006178 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 364106006179 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 364106006180 metal binding site [ion binding]; metal-binding site 364106006181 active site 364106006182 I-site; other site 364106006183 hypothetical protein; Provisional; Region: PRK10062 364106006184 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 364106006185 EamA-like transporter family; Region: EamA; pfam00892 364106006186 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 364106006187 additional DNA contacts [nucleotide binding]; other site 364106006188 mismatch recognition site; other site 364106006189 active site 364106006190 zinc binding site [ion binding]; other site 364106006191 DNA intercalation site [nucleotide binding]; other site 364106006192 DNA cytosine methylase; Provisional; Region: PRK10458 364106006193 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 364106006194 cofactor binding site; other site 364106006195 DNA binding site [nucleotide binding] 364106006196 substrate interaction site [chemical binding]; other site 364106006197 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 364106006198 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 364106006199 Zn2+ binding site [ion binding]; other site 364106006200 Mg2+ binding site [ion binding]; other site 364106006201 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 364106006202 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 364106006203 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 364106006204 eyelet of channel; other site 364106006205 trimer interface [polypeptide binding]; other site 364106006206 chaperone protein HchA; Provisional; Region: PRK04155 364106006207 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 364106006208 dimer interface [polypeptide binding]; other site 364106006209 metal binding site [ion binding]; metal-binding site 364106006210 potential oxyanion hole; other site 364106006211 potential catalytic triad [active] 364106006212 conserved cys residue [active] 364106006213 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 364106006214 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 364106006215 dimer interface [polypeptide binding]; other site 364106006216 phosphorylation site [posttranslational modification] 364106006217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106006218 ATP binding site [chemical binding]; other site 364106006219 Mg2+ binding site [ion binding]; other site 364106006220 G-X-G motif; other site 364106006221 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 364106006222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106006223 active site 364106006224 phosphorylation site [posttranslational modification] 364106006225 intermolecular recognition site; other site 364106006226 dimerization interface [polypeptide binding]; other site 364106006227 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 364106006228 DNA binding site [nucleotide binding] 364106006229 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 364106006230 active site 364106006231 homotetramer interface [polypeptide binding]; other site 364106006232 TMAO/DMSO reductase; Reviewed; Region: PRK05363 364106006233 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 364106006234 Moco binding site; other site 364106006235 metal coordination site [ion binding]; other site 364106006236 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 364106006237 zinc/cadmium-binding protein; Provisional; Region: PRK10306 364106006238 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 364106006239 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 364106006240 active site 364106006241 Int/Topo IB signature motif; other site 364106006242 salicylate synthase Irp9; Reviewed; Region: PRK06772 364106006243 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 364106006244 muropeptide transporter; Validated; Region: ampG; cl17669 364106006245 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 364106006246 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 364106006247 Walker A/P-loop; other site 364106006248 ATP binding site [chemical binding]; other site 364106006249 Q-loop/lid; other site 364106006250 ABC transporter signature motif; other site 364106006251 Walker B; other site 364106006252 D-loop; other site 364106006253 H-loop/switch region; other site 364106006254 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 364106006255 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 364106006256 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 364106006257 Walker A/P-loop; other site 364106006258 ATP binding site [chemical binding]; other site 364106006259 Q-loop/lid; other site 364106006260 ABC transporter signature motif; other site 364106006261 Walker B; other site 364106006262 D-loop; other site 364106006263 H-loop/switch region; other site 364106006264 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 364106006265 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106006266 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 364106006267 Condensation domain; Region: Condensation; pfam00668 364106006268 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 364106006269 Nonribosomal peptide synthase; Region: NRPS; pfam08415 364106006270 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 364106006271 acyl-activating enzyme (AAE) consensus motif; other site 364106006272 AMP binding site [chemical binding]; other site 364106006273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106006274 S-adenosylmethionine binding site [chemical binding]; other site 364106006275 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 364106006276 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 364106006277 Condensation domain; Region: Condensation; pfam00668 364106006278 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 364106006279 Nonribosomal peptide synthase; Region: NRPS; pfam08415 364106006280 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 364106006281 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 364106006282 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 364106006283 active site 364106006284 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 364106006285 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 364106006286 Methyltransferase domain; Region: Methyltransf_12; pfam08242 364106006287 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 364106006288 KR domain; Region: KR; pfam08659 364106006289 NADP binding site [chemical binding]; other site 364106006290 active site 364106006291 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 364106006292 Condensation domain; Region: Condensation; pfam00668 364106006293 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 364106006294 Nonribosomal peptide synthase; Region: NRPS; pfam08415 364106006295 Methyltransferase domain; Region: Methyltransf_12; pfam08242 364106006296 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 364106006297 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 364106006298 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 364106006299 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 364106006300 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 364106006301 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 364106006302 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 364106006303 acyl-activating enzyme (AAE) consensus motif; other site 364106006304 active site 364106006305 AMP binding site [chemical binding]; other site 364106006306 substrate binding site [chemical binding]; other site 364106006307 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 364106006308 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 364106006309 N-terminal plug; other site 364106006310 ligand-binding site [chemical binding]; other site 364106006311 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 364106006312 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 364106006313 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 364106006314 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 364106006315 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 364106006316 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 364106006317 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 364106006318 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 364106006319 shikimate transporter; Provisional; Region: PRK09952 364106006320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106006321 putative substrate translocation pore; other site 364106006322 AMP nucleosidase; Provisional; Region: PRK08292 364106006323 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 364106006324 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 364106006325 hypothetical protein; Provisional; Region: PRK12378 364106006326 MATE family multidrug exporter; Provisional; Region: PRK10189 364106006327 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 364106006328 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 364106006329 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106006330 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 364106006331 putative substrate binding site [chemical binding]; other site 364106006332 dimerization interface [polypeptide binding]; other site 364106006333 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 364106006334 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106006335 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 364106006336 putative dimerization interface [polypeptide binding]; other site 364106006337 integrase; Provisional; Region: PRK09692 364106006338 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 364106006339 active site 364106006340 Int/Topo IB signature motif; other site 364106006341 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 364106006342 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 364106006343 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 364106006344 Beta-lactamase; Region: Beta-lactamase; pfam00144 364106006345 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 364106006346 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 364106006347 active site 364106006348 Condensation domain; Region: Condensation; pfam00668 364106006349 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 364106006350 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 364106006351 acyl-activating enzyme (AAE) consensus motif; other site 364106006352 AMP binding site [chemical binding]; other site 364106006353 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 364106006354 Condensation domain; Region: Condensation; pfam00668 364106006355 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 364106006356 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_6; cd13146 364106006357 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 364106006358 amidase; Provisional; Region: PRK06170 364106006359 Amidase; Region: Amidase; cl11426 364106006360 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 364106006361 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 364106006362 active site 364106006363 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 364106006364 Condensation domain; Region: Condensation; pfam00668 364106006365 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 364106006366 Nonribosomal peptide synthase; Region: NRPS; pfam08415 364106006367 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 364106006368 acyl-activating enzyme (AAE) consensus motif; other site 364106006369 AMP binding site [chemical binding]; other site 364106006370 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 364106006371 putative FMN binding site [chemical binding]; other site 364106006372 NADPH bind site [chemical binding]; other site 364106006373 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 364106006374 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 364106006375 Condensation domain; Region: Condensation; pfam00668 364106006376 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 364106006377 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 364106006378 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 364106006379 acyl-activating enzyme (AAE) consensus motif; other site 364106006380 AMP binding site [chemical binding]; other site 364106006381 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 364106006382 Condensation domain; Region: Condensation; pfam00668 364106006383 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 364106006384 Nonribosomal peptide synthase; Region: NRPS; pfam08415 364106006385 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 364106006386 acyl-activating enzyme (AAE) consensus motif; other site 364106006387 AMP binding site [chemical binding]; other site 364106006388 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 364106006389 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 364106006390 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 364106006391 active site 364106006392 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 364106006393 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 364106006394 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 364106006395 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 364106006396 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 364106006397 acyl-activating enzyme (AAE) consensus motif; other site 364106006398 AMP binding site [chemical binding]; other site 364106006399 Condensation domain; Region: Condensation; pfam00668 364106006400 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 364106006401 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 364106006402 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 364106006403 acyl-activating enzyme (AAE) consensus motif; other site 364106006404 AMP binding site [chemical binding]; other site 364106006405 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 364106006406 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 364106006407 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 364106006408 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 364106006409 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 364106006410 active site 364106006411 acyl carrier protein; Provisional; Region: PRK07081 364106006412 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 364106006413 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 364106006414 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 364106006415 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 364106006416 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 364106006417 active site 364106006418 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 364106006419 Condensation domain; Region: Condensation; pfam00668 364106006420 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 364106006421 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 364106006422 acyl-activating enzyme (AAE) consensus motif; other site 364106006423 AMP binding site [chemical binding]; other site 364106006424 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 364106006425 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 364106006426 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 364106006427 active site 364106006428 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 364106006429 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 364106006430 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 364106006431 KR domain; Region: KR; pfam08659 364106006432 putative NADP binding site [chemical binding]; other site 364106006433 active site 364106006434 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 364106006435 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 364106006436 Enoylreductase; Region: PKS_ER; smart00829 364106006437 NAD(P) binding site [chemical binding]; other site 364106006438 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 364106006439 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 364106006440 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 364106006441 DNA-binding interface [nucleotide binding]; DNA binding site 364106006442 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 364106006443 Integrase core domain; Region: rve; pfam00665 364106006444 Integrase core domain; Region: rve_3; pfam13683 364106006445 Integrase core domain; Region: rve_2; pfam13333 364106006446 L,D-transpeptidase; Provisional; Region: PRK10190 364106006447 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 364106006448 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 364106006449 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 364106006450 putative dimer interface [polypeptide binding]; other site 364106006451 active site pocket [active] 364106006452 putative cataytic base [active] 364106006453 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 364106006454 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 364106006455 homotrimer interface [polypeptide binding]; other site 364106006456 Walker A motif; other site 364106006457 GTP binding site [chemical binding]; other site 364106006458 Walker B motif; other site 364106006459 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 364106006460 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 364106006461 N-terminal plug; other site 364106006462 ligand-binding site [chemical binding]; other site 364106006463 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 364106006464 ParB-like nuclease domain; Region: ParBc; cl02129 364106006465 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 364106006466 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 364106006467 Active Sites [active] 364106006468 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 364106006469 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 364106006470 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 364106006471 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 364106006472 DXD motif; other site 364106006473 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 364106006474 putative trimer interface [polypeptide binding]; other site 364106006475 putative CoA binding site [chemical binding]; other site 364106006476 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 364106006477 Transposase; Region: DEDD_Tnp_IS110; pfam01548 364106006478 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 364106006479 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 364106006480 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 364106006481 active site 364106006482 substrate binding pocket [chemical binding]; other site 364106006483 homodimer interaction site [polypeptide binding]; other site 364106006484 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 364106006485 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 364106006486 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 364106006487 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 364106006488 Haemolysin expression modulating protein; Region: HHA; cl11501 364106006489 Transposase; Region: DEDD_Tnp_IS110; pfam01548 364106006490 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 364106006491 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 364106006492 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 364106006493 transposase/IS protein; Provisional; Region: PRK09183 364106006494 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106006495 Walker A motif; other site 364106006496 ATP binding site [chemical binding]; other site 364106006497 Walker B motif; other site 364106006498 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 364106006499 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 364106006500 DNA-binding interface [nucleotide binding]; DNA binding site 364106006501 Integrase core domain; Region: rve; pfam00665 364106006502 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 364106006503 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 364106006504 Walker A/P-loop; other site 364106006505 ATP binding site [chemical binding]; other site 364106006506 Q-loop/lid; other site 364106006507 ABC transporter signature motif; other site 364106006508 Walker B; other site 364106006509 D-loop; other site 364106006510 H-loop/switch region; other site 364106006511 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 364106006512 dimer interface [polypeptide binding]; other site 364106006513 putative PBP binding regions; other site 364106006514 ABC-ATPase subunit interface; other site 364106006515 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 364106006516 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 364106006517 putative ligand binding residues [chemical binding]; other site 364106006518 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 364106006519 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 364106006520 N-terminal plug; other site 364106006521 ligand-binding site [chemical binding]; other site 364106006522 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 364106006523 G1 box; other site 364106006524 GTP/Mg2+ binding site [chemical binding]; other site 364106006525 G2 box; other site 364106006526 Switch I region; other site 364106006527 Switch II region; other site 364106006528 hypothetical protein; Provisional; Region: PRK09866 364106006529 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 364106006530 G1 box; other site 364106006531 GTP/Mg2+ binding site [chemical binding]; other site 364106006532 G2 box; other site 364106006533 Switch I region; other site 364106006534 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 364106006535 G3 box; other site 364106006536 Switch II region; other site 364106006537 GTP/Mg2+ binding site [chemical binding]; other site 364106006538 G4 box; other site 364106006539 G5 box; other site 364106006540 YjcZ-like protein; Region: YjcZ; pfam13990 364106006541 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 364106006542 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 364106006543 nucleophile elbow; other site 364106006544 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 364106006545 Domain of unknown function (DUF932); Region: DUF932; pfam06067 364106006546 Antirestriction protein; Region: Antirestrict; pfam03230 364106006547 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 364106006548 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 364106006549 MPN+ (JAMM) motif; other site 364106006550 Zinc-binding site [ion binding]; other site 364106006551 Protein of unknown function (DUF987); Region: DUF987; pfam06174 364106006552 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 364106006553 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 364106006554 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 364106006555 Switch II region; other site 364106006556 G4 box; other site 364106006557 G5 box; other site 364106006558 hypothetical protein; Provisional; Region: PRK05423 364106006559 Predicted membrane protein [Function unknown]; Region: COG1289 364106006560 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 364106006561 DNA gyrase inhibitor; Provisional; Region: PRK10016 364106006562 exonuclease I; Provisional; Region: sbcB; PRK11779 364106006563 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 364106006564 active site 364106006565 catalytic site [active] 364106006566 substrate binding site [chemical binding]; other site 364106006567 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 364106006568 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 364106006569 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106006570 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 364106006571 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 364106006572 dimerization interface [polypeptide binding]; other site 364106006573 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 364106006574 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 364106006575 putative NAD(P) binding site [chemical binding]; other site 364106006576 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 364106006577 antitoxin YefM; Provisional; Region: PRK11409 364106006578 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 364106006579 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 364106006580 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 364106006581 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 364106006582 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 364106006583 NAD binding site [chemical binding]; other site 364106006584 dimerization interface [polypeptide binding]; other site 364106006585 product binding site; other site 364106006586 substrate binding site [chemical binding]; other site 364106006587 zinc binding site [ion binding]; other site 364106006588 catalytic residues [active] 364106006589 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 364106006590 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 364106006591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106006592 homodimer interface [polypeptide binding]; other site 364106006593 catalytic residue [active] 364106006594 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 364106006595 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 364106006596 active site 364106006597 motif I; other site 364106006598 motif II; other site 364106006599 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 364106006600 putative active site pocket [active] 364106006601 4-fold oligomerization interface [polypeptide binding]; other site 364106006602 metal binding residues [ion binding]; metal-binding site 364106006603 3-fold/trimer interface [polypeptide binding]; other site 364106006604 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 364106006605 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 364106006606 putative active site [active] 364106006607 oxyanion strand; other site 364106006608 catalytic triad [active] 364106006609 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 364106006610 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 364106006611 catalytic residues [active] 364106006612 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 364106006613 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 364106006614 substrate binding site [chemical binding]; other site 364106006615 glutamase interaction surface [polypeptide binding]; other site 364106006616 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 364106006617 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 364106006618 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 364106006619 metal binding site [ion binding]; metal-binding site 364106006620 chain length determinant protein WzzB; Provisional; Region: PRK15471 364106006621 Chain length determinant protein; Region: Wzz; pfam02706 364106006622 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 364106006623 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 364106006624 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 364106006625 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 364106006626 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 364106006627 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 364106006628 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 364106006629 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 364106006630 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 364106006631 putative ADP-binding pocket [chemical binding]; other site 364106006632 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 364106006633 This family is most closely related to the GT1 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor...; Region: GT1_WbdM_like; cd04951 364106006634 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 364106006635 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 364106006636 active site 364106006637 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 364106006638 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 364106006639 Probable Catalytic site; other site 364106006640 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 364106006641 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 364106006642 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 364106006643 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 364106006644 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 364106006645 substrate binding site; other site 364106006646 tetramer interface; other site 364106006647 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 364106006648 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 364106006649 NADP binding site [chemical binding]; other site 364106006650 active site 364106006651 putative substrate binding site [chemical binding]; other site 364106006652 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 364106006653 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 364106006654 NAD binding site [chemical binding]; other site 364106006655 substrate binding site [chemical binding]; other site 364106006656 homodimer interface [polypeptide binding]; other site 364106006657 active site 364106006658 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 364106006659 active site 364106006660 tetramer interface; other site 364106006661 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 364106006662 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 364106006663 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 364106006664 putative ADP-binding pocket [chemical binding]; other site 364106006665 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 364106006666 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 364106006667 colanic acid exporter; Provisional; Region: PRK10459 364106006668 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 364106006669 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 364106006670 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 364106006671 phosphomannomutase CpsG; Provisional; Region: PRK15414 364106006672 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 364106006673 active site 364106006674 substrate binding site [chemical binding]; other site 364106006675 metal binding site [ion binding]; metal-binding site 364106006676 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 364106006677 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 364106006678 Substrate binding site; other site 364106006679 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 364106006680 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 364106006681 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 364106006682 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 364106006683 active site 364106006684 GDP-Mannose binding site [chemical binding]; other site 364106006685 dimer interface [polypeptide binding]; other site 364106006686 modified nudix motif 364106006687 metal binding site [ion binding]; metal-binding site 364106006688 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 364106006689 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 364106006690 NADP binding site [chemical binding]; other site 364106006691 active site 364106006692 putative substrate binding site [chemical binding]; other site 364106006693 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 364106006694 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 364106006695 NADP-binding site; other site 364106006696 homotetramer interface [polypeptide binding]; other site 364106006697 substrate binding site [chemical binding]; other site 364106006698 homodimer interface [polypeptide binding]; other site 364106006699 active site 364106006700 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 364106006701 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 364106006702 putative trimer interface [polypeptide binding]; other site 364106006703 putative active site [active] 364106006704 putative substrate binding site [chemical binding]; other site 364106006705 putative CoA binding site [chemical binding]; other site 364106006706 putative glycosyl transferase; Provisional; Region: PRK10063 364106006707 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 364106006708 metal-binding site 364106006709 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 364106006710 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 364106006711 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 364106006712 putative acyl transferase; Provisional; Region: PRK10191 364106006713 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 364106006714 trimer interface [polypeptide binding]; other site 364106006715 active site 364106006716 substrate binding site [chemical binding]; other site 364106006717 CoA binding site [chemical binding]; other site 364106006718 putative glycosyl transferase; Provisional; Region: PRK10018 364106006719 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 364106006720 active site 364106006721 tyrosine kinase; Provisional; Region: PRK11519 364106006722 Chain length determinant protein; Region: Wzz; pfam02706 364106006723 Chain length determinant protein; Region: Wzz; cl15801 364106006724 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 364106006725 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 364106006726 Low molecular weight phosphatase family; Region: LMWPc; cd00115 364106006727 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 364106006728 active site 364106006729 polysaccharide export protein Wza; Provisional; Region: PRK15078 364106006730 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 364106006731 SLBB domain; Region: SLBB; pfam10531 364106006732 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 364106006733 FOG: CBS domain [General function prediction only]; Region: COG0517 364106006734 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 364106006735 Transporter associated domain; Region: CorC_HlyC; smart01091 364106006736 Phage-related protein [Function unknown]; Region: COG4679 364106006737 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 364106006738 putative assembly protein; Provisional; Region: PRK10833 364106006739 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 364106006740 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 364106006741 trimer interface [polypeptide binding]; other site 364106006742 active site 364106006743 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 364106006744 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 364106006745 ATP-binding site [chemical binding]; other site 364106006746 Sugar specificity; other site 364106006747 Pyrimidine base specificity; other site 364106006748 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 364106006749 putative diguanylate cyclase; Provisional; Region: PRK09776 364106006750 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 364106006751 putative active site [active] 364106006752 heme pocket [chemical binding]; other site 364106006753 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 364106006754 putative active site [active] 364106006755 heme pocket [chemical binding]; other site 364106006756 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 364106006757 putative active site [active] 364106006758 heme pocket [chemical binding]; other site 364106006759 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 364106006760 metal binding site [ion binding]; metal-binding site 364106006761 active site 364106006762 I-site; other site 364106006763 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 364106006764 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 364106006765 AlkA N-terminal domain; Region: AlkA_N; smart01009 364106006766 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 364106006767 minor groove reading motif; other site 364106006768 helix-hairpin-helix signature motif; other site 364106006769 substrate binding pocket [chemical binding]; other site 364106006770 active site 364106006771 putative chaperone; Provisional; Region: PRK11678 364106006772 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 364106006773 nucleotide binding site [chemical binding]; other site 364106006774 putative NEF/HSP70 interaction site [polypeptide binding]; other site 364106006775 SBD interface [polypeptide binding]; other site 364106006776 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 364106006777 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 364106006778 substrate binding site [chemical binding]; other site 364106006779 activation loop (A-loop); other site 364106006780 Y-family of DNA polymerases; Region: PolY; cl12025 364106006781 Protein phosphatase 2C; Region: PP2C_2; pfam13672 364106006782 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 364106006783 metal ion-dependent adhesion site (MIDAS); other site 364106006784 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 364106006785 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 364106006786 HlyD family secretion protein; Region: HlyD_3; pfam13437 364106006787 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 364106006788 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 364106006789 Protein export membrane protein; Region: SecD_SecF; cl14618 364106006790 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 364106006791 putative transporter; Provisional; Region: PRK10504 364106006792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106006793 putative substrate translocation pore; other site 364106006794 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 364106006795 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 364106006796 dimerization interface [polypeptide binding]; other site 364106006797 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 364106006798 dimer interface [polypeptide binding]; other site 364106006799 phosphorylation site [posttranslational modification] 364106006800 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106006801 ATP binding site [chemical binding]; other site 364106006802 Mg2+ binding site [ion binding]; other site 364106006803 G-X-G motif; other site 364106006804 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 364106006805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106006806 active site 364106006807 phosphorylation site [posttranslational modification] 364106006808 intermolecular recognition site; other site 364106006809 dimerization interface [polypeptide binding]; other site 364106006810 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 364106006811 DNA binding site [nucleotide binding] 364106006812 Uncharacterized conserved protein [Function unknown]; Region: COG3422 364106006813 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 364106006814 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 364106006815 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 364106006816 PcfJ-like protein; Region: PcfJ; pfam14284 364106006817 putative protease; Provisional; Region: PRK15452 364106006818 Peptidase family U32; Region: Peptidase_U32; pfam01136 364106006819 lipid kinase; Reviewed; Region: PRK13054 364106006820 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 364106006821 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 364106006822 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 364106006823 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 364106006824 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 364106006825 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 364106006826 putative NAD(P) binding site [chemical binding]; other site 364106006827 catalytic Zn binding site [ion binding]; other site 364106006828 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 364106006829 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 364106006830 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 364106006831 active site 364106006832 P-loop; other site 364106006833 phosphorylation site [posttranslational modification] 364106006834 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 364106006835 active site 364106006836 phosphorylation site [posttranslational modification] 364106006837 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 364106006838 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 364106006839 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 364106006840 intersubunit interface [polypeptide binding]; other site 364106006841 active site 364106006842 zinc binding site [ion binding]; other site 364106006843 Na+ binding site [ion binding]; other site 364106006844 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 364106006845 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 364106006846 putative active site; other site 364106006847 catalytic residue [active] 364106006848 nucleoside transporter; Region: 2A0110; TIGR00889 364106006849 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106006850 putative substrate translocation pore; other site 364106006851 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 364106006852 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 364106006853 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 364106006854 substrate binding site [chemical binding]; other site 364106006855 ATP binding site [chemical binding]; other site 364106006856 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 364106006857 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 364106006858 DNA-binding site [nucleotide binding]; DNA binding site 364106006859 UTRA domain; Region: UTRA; pfam07702 364106006860 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 364106006861 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 364106006862 active site 364106006863 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 364106006864 dimer interface [polypeptide binding]; other site 364106006865 substrate binding site [chemical binding]; other site 364106006866 ATP binding site [chemical binding]; other site 364106006867 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 364106006868 substrate binding site [chemical binding]; other site 364106006869 multimerization interface [polypeptide binding]; other site 364106006870 ATP binding site [chemical binding]; other site 364106006871 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 364106006872 putative metal binding site [ion binding]; other site 364106006873 putative homodimer interface [polypeptide binding]; other site 364106006874 putative homotetramer interface [polypeptide binding]; other site 364106006875 putative homodimer-homodimer interface [polypeptide binding]; other site 364106006876 putative allosteric switch controlling residues; other site 364106006877 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 364106006878 Predicted integral membrane protein [Function unknown]; Region: COG5455 364106006879 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 364106006880 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 364106006881 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 364106006882 PapC N-terminal domain; Region: PapC_N; pfam13954 364106006883 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 364106006884 PapC C-terminal domain; Region: PapC_C; pfam13953 364106006885 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 364106006886 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 364106006887 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 364106006888 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 364106006889 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 364106006890 antiporter inner membrane protein; Provisional; Region: PRK11670 364106006891 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 364106006892 Walker A motif; other site 364106006893 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 364106006894 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 364106006895 active site 364106006896 HIGH motif; other site 364106006897 KMSKS motif; other site 364106006898 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 364106006899 tRNA binding surface [nucleotide binding]; other site 364106006900 anticodon binding site; other site 364106006901 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 364106006902 dimer interface [polypeptide binding]; other site 364106006903 putative tRNA-binding site [nucleotide binding]; other site 364106006904 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 364106006905 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 364106006906 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 364106006907 MoxR-like ATPases [General function prediction only]; Region: COG0714 364106006908 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 364106006909 Walker A motif; other site 364106006910 ATP binding site [chemical binding]; other site 364106006911 Walker B motif; other site 364106006912 arginine finger; other site 364106006913 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 364106006914 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 364106006915 metal ion-dependent adhesion site (MIDAS); other site 364106006916 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 364106006917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 364106006918 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 364106006919 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 364106006920 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 364106006921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106006922 active site 364106006923 phosphorylation site [posttranslational modification] 364106006924 intermolecular recognition site; other site 364106006925 dimerization interface [polypeptide binding]; other site 364106006926 LytTr DNA-binding domain; Region: LytTR; pfam04397 364106006927 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 364106006928 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 364106006929 GAF domain; Region: GAF; pfam01590 364106006930 Histidine kinase; Region: His_kinase; pfam06580 364106006931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106006932 ATP binding site [chemical binding]; other site 364106006933 Mg2+ binding site [ion binding]; other site 364106006934 G-X-G motif; other site 364106006935 transcriptional regulator MirA; Provisional; Region: PRK15043 364106006936 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 364106006937 DNA binding residues [nucleotide binding] 364106006938 hypothetical protein; Provisional; Region: PRK13681 364106006939 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 364106006940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106006941 dimer interface [polypeptide binding]; other site 364106006942 conserved gate region; other site 364106006943 putative PBP binding loops; other site 364106006944 ABC-ATPase subunit interface; other site 364106006945 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 364106006946 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 364106006947 Walker A/P-loop; other site 364106006948 ATP binding site [chemical binding]; other site 364106006949 Q-loop/lid; other site 364106006950 ABC transporter signature motif; other site 364106006951 Walker B; other site 364106006952 D-loop; other site 364106006953 H-loop/switch region; other site 364106006954 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 364106006955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106006956 dimer interface [polypeptide binding]; other site 364106006957 conserved gate region; other site 364106006958 ABC-ATPase subunit interface; other site 364106006959 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 364106006960 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 364106006961 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 364106006962 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 364106006963 D-lactate dehydrogenase; Provisional; Region: PRK11183 364106006964 FAD binding domain; Region: FAD_binding_4; pfam01565 364106006965 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 364106006966 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 364106006967 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 364106006968 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 364106006969 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 364106006970 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 364106006971 oxidoreductase; Provisional; Region: PRK12743 364106006972 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 364106006973 NAD(P) binding site [chemical binding]; other site 364106006974 active site 364106006975 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 364106006976 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 364106006977 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 364106006978 FMN binding site [chemical binding]; other site 364106006979 active site 364106006980 catalytic residues [active] 364106006981 substrate binding site [chemical binding]; other site 364106006982 hypothetical protein; Provisional; Region: PRK01821 364106006983 hypothetical protein; Provisional; Region: PRK10711 364106006984 cytidine deaminase; Provisional; Region: PRK09027 364106006985 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 364106006986 active site 364106006987 catalytic motif [active] 364106006988 Zn binding site [ion binding]; other site 364106006989 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 364106006990 active site 364106006991 catalytic motif [active] 364106006992 Zn binding site [ion binding]; other site 364106006993 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 364106006994 putative active site [active] 364106006995 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 364106006996 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 364106006997 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 364106006998 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 364106006999 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 364106007000 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 364106007001 homodimer interface [polypeptide binding]; other site 364106007002 active site 364106007003 FMN binding site [chemical binding]; other site 364106007004 substrate binding site [chemical binding]; other site 364106007005 4Fe-4S binding domain; Region: Fer4; pfam00037 364106007006 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 364106007007 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 364106007008 TM-ABC transporter signature motif; other site 364106007009 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 364106007010 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 364106007011 Walker A/P-loop; other site 364106007012 ATP binding site [chemical binding]; other site 364106007013 Q-loop/lid; other site 364106007014 ABC transporter signature motif; other site 364106007015 Walker B; other site 364106007016 D-loop; other site 364106007017 H-loop/switch region; other site 364106007018 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 364106007019 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 364106007020 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 364106007021 ligand binding site [chemical binding]; other site 364106007022 calcium binding site [ion binding]; other site 364106007023 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 364106007024 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 364106007025 DNA binding site [nucleotide binding] 364106007026 domain linker motif; other site 364106007027 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 364106007028 dimerization interface (closed form) [polypeptide binding]; other site 364106007029 ligand binding site [chemical binding]; other site 364106007030 Predicted membrane protein [Function unknown]; Region: COG2311 364106007031 hypothetical protein; Provisional; Region: PRK10835 364106007032 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 364106007033 homodecamer interface [polypeptide binding]; other site 364106007034 GTP cyclohydrolase I; Provisional; Region: PLN03044 364106007035 active site 364106007036 putative catalytic site residues [active] 364106007037 zinc binding site [ion binding]; other site 364106007038 GTP-CH-I/GFRP interaction surface; other site 364106007039 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 364106007040 S-formylglutathione hydrolase; Region: PLN02442 364106007041 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 364106007042 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 364106007043 N-terminal plug; other site 364106007044 ligand-binding site [chemical binding]; other site 364106007045 lysine transporter; Provisional; Region: PRK10836 364106007046 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 364106007047 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106007048 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 364106007049 putative dimerization interface [polypeptide binding]; other site 364106007050 conserved hypothetical integral membrane protein; Region: TIGR00698 364106007051 endonuclease IV; Provisional; Region: PRK01060 364106007052 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 364106007053 AP (apurinic/apyrimidinic) site pocket; other site 364106007054 DNA interaction; other site 364106007055 Metal-binding active site; metal-binding site 364106007056 putative kinase; Provisional; Region: PRK09954 364106007057 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 364106007058 putative DNA binding site [nucleotide binding]; other site 364106007059 putative Zn2+ binding site [ion binding]; other site 364106007060 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 364106007061 substrate binding site [chemical binding]; other site 364106007062 ATP binding site [chemical binding]; other site 364106007063 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 364106007064 active site 364106007065 tetramer interface [polypeptide binding]; other site 364106007066 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 364106007067 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 364106007068 ligand binding site [chemical binding]; other site 364106007069 flexible hinge region; other site 364106007070 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 364106007071 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 364106007072 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 364106007073 Nucleoside recognition; Region: Gate; pfam07670 364106007074 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 364106007075 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 364106007076 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 364106007077 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 364106007078 substrate binding site [chemical binding]; other site 364106007079 ATP binding site [chemical binding]; other site 364106007080 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 364106007081 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 364106007082 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 364106007083 active site 364106007084 P-loop; other site 364106007085 phosphorylation site [posttranslational modification] 364106007086 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 364106007087 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 364106007088 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 364106007089 putative substrate binding site [chemical binding]; other site 364106007090 putative ATP binding site [chemical binding]; other site 364106007091 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 364106007092 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 364106007093 active site 364106007094 phosphorylation site [posttranslational modification] 364106007095 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 364106007096 dimerization domain swap beta strand [polypeptide binding]; other site 364106007097 regulatory protein interface [polypeptide binding]; other site 364106007098 active site 364106007099 regulatory phosphorylation site [posttranslational modification]; other site 364106007100 sugar efflux transporter B; Provisional; Region: PRK15011 364106007101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106007102 putative substrate translocation pore; other site 364106007103 elongation factor P; Provisional; Region: PRK04542 364106007104 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 364106007105 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 364106007106 RNA binding site [nucleotide binding]; other site 364106007107 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 364106007108 RNA binding site [nucleotide binding]; other site 364106007109 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 364106007110 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 364106007111 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 364106007112 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 364106007113 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 364106007114 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 364106007115 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 364106007116 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 364106007117 active site 364106007118 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 364106007119 NlpC/P60 family; Region: NLPC_P60; pfam00877 364106007120 phage resistance protein; Provisional; Region: PRK10551 364106007121 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 364106007122 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 364106007123 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 364106007124 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 364106007125 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 364106007126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106007127 dimer interface [polypeptide binding]; other site 364106007128 conserved gate region; other site 364106007129 putative PBP binding loops; other site 364106007130 ABC-ATPase subunit interface; other site 364106007131 microcin C ABC transporter permease; Provisional; Region: PRK15021 364106007132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106007133 dimer interface [polypeptide binding]; other site 364106007134 conserved gate region; other site 364106007135 ABC-ATPase subunit interface; other site 364106007136 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 364106007137 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 364106007138 Walker A/P-loop; other site 364106007139 ATP binding site [chemical binding]; other site 364106007140 Q-loop/lid; other site 364106007141 ABC transporter signature motif; other site 364106007142 Walker B; other site 364106007143 D-loop; other site 364106007144 H-loop/switch region; other site 364106007145 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 364106007146 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 364106007147 Walker A/P-loop; other site 364106007148 ATP binding site [chemical binding]; other site 364106007149 Q-loop/lid; other site 364106007150 ABC transporter signature motif; other site 364106007151 Walker B; other site 364106007152 D-loop; other site 364106007153 H-loop/switch region; other site 364106007154 hypothetical protein; Provisional; Region: PRK11835 364106007155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106007156 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 364106007157 putative substrate translocation pore; other site 364106007158 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 364106007159 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 364106007160 RNA binding surface [nucleotide binding]; other site 364106007161 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 364106007162 active site 364106007163 uracil binding [chemical binding]; other site 364106007164 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 364106007165 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 364106007166 ATP binding site [chemical binding]; other site 364106007167 putative Mg++ binding site [ion binding]; other site 364106007168 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 364106007169 nucleotide binding region [chemical binding]; other site 364106007170 ATP-binding site [chemical binding]; other site 364106007171 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 364106007172 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 364106007173 5S rRNA interface [nucleotide binding]; other site 364106007174 CTC domain interface [polypeptide binding]; other site 364106007175 L16 interface [polypeptide binding]; other site 364106007176 Nucleoid-associated protein [General function prediction only]; Region: COG3081 364106007177 nucleoid-associated protein NdpA; Validated; Region: PRK00378 364106007178 hypothetical protein; Provisional; Region: PRK13689 364106007179 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 364106007180 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 364106007181 Sulfatase; Region: Sulfatase; pfam00884 364106007182 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 364106007183 transcriptional regulator NarP; Provisional; Region: PRK10403 364106007184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106007185 active site 364106007186 phosphorylation site [posttranslational modification] 364106007187 intermolecular recognition site; other site 364106007188 dimerization interface [polypeptide binding]; other site 364106007189 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 364106007190 DNA binding residues [nucleotide binding] 364106007191 dimerization interface [polypeptide binding]; other site 364106007192 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 364106007193 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 364106007194 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 364106007195 binding surface 364106007196 TPR motif; other site 364106007197 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 364106007198 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 364106007199 catalytic residues [active] 364106007200 central insert; other site 364106007201 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 364106007202 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 364106007203 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 364106007204 heme exporter protein CcmC; Region: ccmC; TIGR01191 364106007205 heme exporter protein CcmB; Region: ccmB; TIGR01190 364106007206 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 364106007207 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 364106007208 Walker A/P-loop; other site 364106007209 ATP binding site [chemical binding]; other site 364106007210 Q-loop/lid; other site 364106007211 ABC transporter signature motif; other site 364106007212 Walker B; other site 364106007213 D-loop; other site 364106007214 H-loop/switch region; other site 364106007215 cytochrome c-type protein NapC; Provisional; Region: PRK10617 364106007216 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 364106007217 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 364106007218 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 364106007219 4Fe-4S binding domain; Region: Fer4_5; pfam12801 364106007220 4Fe-4S binding domain; Region: Fer4_6; pfam12837 364106007221 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 364106007222 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 364106007223 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 364106007224 [4Fe-4S] binding site [ion binding]; other site 364106007225 molybdopterin cofactor binding site; other site 364106007226 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 364106007227 molybdopterin cofactor binding site; other site 364106007228 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 364106007229 ferredoxin-type protein; Provisional; Region: PRK10194 364106007230 tRNA synthetases class I (R); Region: tRNA-synt_1d; pfam00750 364106007231 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 364106007232 secondary substrate binding site; other site 364106007233 primary substrate binding site; other site 364106007234 inhibition loop; other site 364106007235 dimerization interface [polypeptide binding]; other site 364106007236 malate:quinone oxidoreductase; Validated; Region: PRK05257 364106007237 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 364106007238 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 364106007239 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 364106007240 Walker A/P-loop; other site 364106007241 ATP binding site [chemical binding]; other site 364106007242 Q-loop/lid; other site 364106007243 ABC transporter signature motif; other site 364106007244 Walker B; other site 364106007245 D-loop; other site 364106007246 H-loop/switch region; other site 364106007247 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 364106007248 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 364106007249 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 364106007250 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106007251 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 364106007252 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 364106007253 DNA binding site [nucleotide binding] 364106007254 active site 364106007255 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 364106007256 ApbE family; Region: ApbE; pfam02424 364106007257 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 364106007258 outer membrane porin protein C; Provisional; Region: PRK10554 364106007259 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 364106007260 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106007261 ATP binding site [chemical binding]; other site 364106007262 G-X-G motif; other site 364106007263 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 364106007264 putative binding surface; other site 364106007265 active site 364106007266 transcriptional regulator RcsB; Provisional; Region: PRK10840 364106007267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106007268 active site 364106007269 phosphorylation site [posttranslational modification] 364106007270 intermolecular recognition site; other site 364106007271 dimerization interface [polypeptide binding]; other site 364106007272 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 364106007273 DNA binding residues [nucleotide binding] 364106007274 dimerization interface [polypeptide binding]; other site 364106007275 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 364106007276 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 364106007277 dimer interface [polypeptide binding]; other site 364106007278 phosphorylation site [posttranslational modification] 364106007279 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106007280 ATP binding site [chemical binding]; other site 364106007281 Mg2+ binding site [ion binding]; other site 364106007282 G-X-G motif; other site 364106007283 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 364106007284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106007285 active site 364106007286 phosphorylation site [posttranslational modification] 364106007287 intermolecular recognition site; other site 364106007288 dimerization interface [polypeptide binding]; other site 364106007289 sensory histidine kinase AtoS; Provisional; Region: PRK11360 364106007290 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 364106007291 putative active site [active] 364106007292 heme pocket [chemical binding]; other site 364106007293 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 364106007294 dimer interface [polypeptide binding]; other site 364106007295 phosphorylation site [posttranslational modification] 364106007296 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106007297 ATP binding site [chemical binding]; other site 364106007298 Mg2+ binding site [ion binding]; other site 364106007299 G-X-G motif; other site 364106007300 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 364106007301 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106007302 active site 364106007303 phosphorylation site [posttranslational modification] 364106007304 intermolecular recognition site; other site 364106007305 dimerization interface [polypeptide binding]; other site 364106007306 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106007307 Walker A motif; other site 364106007308 ATP binding site [chemical binding]; other site 364106007309 Walker B motif; other site 364106007310 arginine finger; other site 364106007311 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 364106007312 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920 364106007313 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 364106007314 Short chain fatty acid transporter; Region: SCFA_trans; pfam02667 364106007315 putative acyltransferase; Provisional; Region: PRK05790 364106007316 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 364106007317 dimer interface [polypeptide binding]; other site 364106007318 active site 364106007319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 364106007320 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 364106007321 Predicted secreted protein [Function unknown]; Region: COG5445 364106007322 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 364106007323 Predicted secreted protein [Function unknown]; Region: COG5445 364106007324 Stage II sporulation protein; Region: SpoIID; pfam08486 364106007325 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 364106007326 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 364106007327 MG2 domain; Region: A2M_N; pfam01835 364106007328 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 364106007329 Alpha-2-macroglobulin family; Region: A2M; pfam00207 364106007330 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 364106007331 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 364106007332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 364106007333 DNA gyrase subunit A; Validated; Region: PRK05560 364106007334 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 364106007335 CAP-like domain; other site 364106007336 active site 364106007337 primary dimer interface [polypeptide binding]; other site 364106007338 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 364106007339 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 364106007340 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 364106007341 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 364106007342 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 364106007343 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 364106007344 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 364106007345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106007346 S-adenosylmethionine binding site [chemical binding]; other site 364106007347 adhesin; Provisional; Region: PRK09752 364106007348 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 364106007349 Autotransporter beta-domain; Region: Autotransporter; pfam03797 364106007350 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 364106007351 ATP cone domain; Region: ATP-cone; pfam03477 364106007352 Class I ribonucleotide reductase; Region: RNR_I; cd01679 364106007353 active site 364106007354 dimer interface [polypeptide binding]; other site 364106007355 catalytic residues [active] 364106007356 effector binding site; other site 364106007357 R2 peptide binding site; other site 364106007358 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 364106007359 dimer interface [polypeptide binding]; other site 364106007360 putative radical transfer pathway; other site 364106007361 diiron center [ion binding]; other site 364106007362 tyrosyl radical; other site 364106007363 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 364106007364 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 364106007365 catalytic loop [active] 364106007366 iron binding site [ion binding]; other site 364106007367 hypothetical protein; Provisional; Region: PRK09902 364106007368 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 364106007369 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 364106007370 active site 364106007371 catalytic site [active] 364106007372 metal binding site [ion binding]; metal-binding site 364106007373 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 364106007374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106007375 putative substrate translocation pore; other site 364106007376 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 364106007377 hydroxyglutarate oxidase; Provisional; Region: PRK11728 364106007378 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 364106007379 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 364106007380 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 364106007381 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 364106007382 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 364106007383 Cysteine-rich domain; Region: CCG; pfam02754 364106007384 Cysteine-rich domain; Region: CCG; pfam02754 364106007385 hypothetical protein; Provisional; Region: PRK09956 364106007386 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 364106007387 hypothetical protein; Provisional; Region: PRK09956 364106007388 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 364106007389 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 364106007390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106007391 putative substrate translocation pore; other site 364106007392 L-rhamnonate dehydratase; Provisional; Region: PRK15440 364106007393 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 364106007394 putative active site pocket [active] 364106007395 putative metal binding site [ion binding]; other site 364106007396 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 364106007397 Transcriptional regulator [Transcription]; Region: IclR; COG1414 364106007398 Bacterial transcriptional regulator; Region: IclR; pfam01614 364106007399 hypothetical protein; Provisional; Region: PRK03673 364106007400 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 364106007401 putative MPT binding site; other site 364106007402 Competence-damaged protein; Region: CinA; cl00666 364106007403 YfaZ precursor; Region: YfaZ; pfam07437 364106007404 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 364106007405 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 364106007406 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 364106007407 catalytic core [active] 364106007408 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 364106007409 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 364106007410 inhibitor-cofactor binding pocket; inhibition site 364106007411 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106007412 catalytic residue [active] 364106007413 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 364106007414 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 364106007415 Ligand binding site; other site 364106007416 Putative Catalytic site; other site 364106007417 DXD motif; other site 364106007418 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 364106007419 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 364106007420 substrate binding site [chemical binding]; other site 364106007421 cosubstrate binding site; other site 364106007422 catalytic site [active] 364106007423 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 364106007424 active site 364106007425 hexamer interface [polypeptide binding]; other site 364106007426 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 364106007427 NAD binding site [chemical binding]; other site 364106007428 substrate binding site [chemical binding]; other site 364106007429 active site 364106007430 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 364106007431 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 364106007432 putative active site [active] 364106007433 putative catalytic site [active] 364106007434 putative Zn binding site [ion binding]; other site 364106007435 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 364106007436 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 364106007437 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 364106007438 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 364106007439 signal transduction protein PmrD; Provisional; Region: PRK15450 364106007440 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 364106007441 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 364106007442 acyl-activating enzyme (AAE) consensus motif; other site 364106007443 putative AMP binding site [chemical binding]; other site 364106007444 putative active site [active] 364106007445 putative CoA binding site [chemical binding]; other site 364106007446 O-succinylbenzoate synthase; Provisional; Region: PRK05105 364106007447 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 364106007448 active site 364106007449 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 364106007450 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 364106007451 substrate binding site [chemical binding]; other site 364106007452 oxyanion hole (OAH) forming residues; other site 364106007453 trimer interface [polypeptide binding]; other site 364106007454 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 364106007455 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 364106007456 catalytic site [active] 364106007457 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 364106007458 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 364106007459 dimer interface [polypeptide binding]; other site 364106007460 tetramer interface [polypeptide binding]; other site 364106007461 PYR/PP interface [polypeptide binding]; other site 364106007462 TPP binding site [chemical binding]; other site 364106007463 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 364106007464 TPP-binding site; other site 364106007465 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 364106007466 isochorismate synthases; Region: isochor_syn; TIGR00543 364106007467 hypothetical protein; Provisional; Region: PRK10404 364106007468 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 364106007469 Coenzyme A binding pocket [chemical binding]; other site 364106007470 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 364106007471 von Willebrand factor; Region: vWF_A; pfam12450 364106007472 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 364106007473 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 364106007474 metal ion-dependent adhesion site (MIDAS); other site 364106007475 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 364106007476 M28 Zn-Peptidases; Region: M28_like_1; cd05640 364106007477 Peptidase family M28; Region: Peptidase_M28; pfam04389 364106007478 metal binding site [ion binding]; metal-binding site 364106007479 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 364106007480 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 364106007481 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 364106007482 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 364106007483 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 364106007484 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 364106007485 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 364106007486 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 364106007487 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 364106007488 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 364106007489 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 364106007490 4Fe-4S binding domain; Region: Fer4; pfam00037 364106007491 4Fe-4S binding domain; Region: Fer4; pfam00037 364106007492 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 364106007493 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 364106007494 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 364106007495 catalytic loop [active] 364106007496 iron binding site [ion binding]; other site 364106007497 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 364106007498 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 364106007499 [4Fe-4S] binding site [ion binding]; other site 364106007500 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 364106007501 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 364106007502 SLBB domain; Region: SLBB; pfam10531 364106007503 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 364106007504 NADH dehydrogenase subunit E; Validated; Region: PRK07539 364106007505 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 364106007506 putative dimer interface [polypeptide binding]; other site 364106007507 [2Fe-2S] cluster binding site [ion binding]; other site 364106007508 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 364106007509 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 364106007510 NADH dehydrogenase subunit D; Validated; Region: PRK06075 364106007511 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 364106007512 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 364106007513 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 364106007514 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106007515 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 364106007516 putative dimerization interface [polypeptide binding]; other site 364106007517 aminotransferase AlaT; Validated; Region: PRK09265 364106007518 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 364106007519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106007520 homodimer interface [polypeptide binding]; other site 364106007521 catalytic residue [active] 364106007522 5'-nucleotidase; Provisional; Region: PRK03826 364106007523 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 364106007524 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 364106007525 TrkA-C domain; Region: TrkA_C; pfam02080 364106007526 TrkA-C domain; Region: TrkA_C; pfam02080 364106007527 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 364106007528 putative phosphatase; Provisional; Region: PRK11587 364106007529 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 364106007530 motif II; other site 364106007531 hypothetical protein; Validated; Region: PRK05445 364106007532 hypothetical protein; Provisional; Region: PRK01816 364106007533 propionate/acetate kinase; Provisional; Region: PRK12379 364106007534 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 364106007535 phosphate acetyltransferase; Reviewed; Region: PRK05632 364106007536 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 364106007537 DRTGG domain; Region: DRTGG; pfam07085 364106007538 phosphate acetyltransferase; Region: pta; TIGR00651 364106007539 hypothetical protein; Provisional; Region: PRK11588 364106007540 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 364106007541 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 364106007542 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 364106007543 nudix motif; other site 364106007544 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 364106007545 active site 364106007546 metal binding site [ion binding]; metal-binding site 364106007547 homotetramer interface [polypeptide binding]; other site 364106007548 glutathione S-transferase; Provisional; Region: PRK15113 364106007549 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 364106007550 C-terminal domain interface [polypeptide binding]; other site 364106007551 GSH binding site (G-site) [chemical binding]; other site 364106007552 dimer interface [polypeptide binding]; other site 364106007553 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 364106007554 N-terminal domain interface [polypeptide binding]; other site 364106007555 putative dimer interface [polypeptide binding]; other site 364106007556 putative substrate binding pocket (H-site) [chemical binding]; other site 364106007557 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 364106007558 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 364106007559 C-terminal domain interface [polypeptide binding]; other site 364106007560 GSH binding site (G-site) [chemical binding]; other site 364106007561 dimer interface [polypeptide binding]; other site 364106007562 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 364106007563 N-terminal domain interface [polypeptide binding]; other site 364106007564 putative dimer interface [polypeptide binding]; other site 364106007565 active site 364106007566 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 364106007567 homooctamer interface [polypeptide binding]; other site 364106007568 active site 364106007569 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 364106007570 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 364106007571 putative NAD(P) binding site [chemical binding]; other site 364106007572 putative active site [active] 364106007573 putative transposase; Provisional; Region: PRK09857 364106007574 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 364106007575 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 364106007576 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 364106007577 Walker A/P-loop; other site 364106007578 ATP binding site [chemical binding]; other site 364106007579 Q-loop/lid; other site 364106007580 ABC transporter signature motif; other site 364106007581 Walker B; other site 364106007582 D-loop; other site 364106007583 H-loop/switch region; other site 364106007584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106007585 dimer interface [polypeptide binding]; other site 364106007586 conserved gate region; other site 364106007587 putative PBP binding loops; other site 364106007588 ABC-ATPase subunit interface; other site 364106007589 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 364106007590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106007591 dimer interface [polypeptide binding]; other site 364106007592 conserved gate region; other site 364106007593 putative PBP binding loops; other site 364106007594 ABC-ATPase subunit interface; other site 364106007595 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 364106007596 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 364106007597 substrate binding pocket [chemical binding]; other site 364106007598 membrane-bound complex binding site; other site 364106007599 hinge residues; other site 364106007600 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 364106007601 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 364106007602 substrate binding pocket [chemical binding]; other site 364106007603 membrane-bound complex binding site; other site 364106007604 hinge residues; other site 364106007605 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 364106007606 Flavoprotein; Region: Flavoprotein; pfam02441 364106007607 amidophosphoribosyltransferase; Provisional; Region: PRK09246 364106007608 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 364106007609 active site 364106007610 tetramer interface [polypeptide binding]; other site 364106007611 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 364106007612 active site 364106007613 colicin V production protein; Provisional; Region: PRK10845 364106007614 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 364106007615 cell division protein DedD; Provisional; Region: PRK11633 364106007616 Sporulation related domain; Region: SPOR; pfam05036 364106007617 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 364106007618 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 364106007619 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 364106007620 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 364106007621 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 364106007622 hypothetical protein; Provisional; Region: PRK10847 364106007623 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 364106007624 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 364106007625 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 364106007626 dimerization interface 3.5A [polypeptide binding]; other site 364106007627 active site 364106007628 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 364106007629 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 364106007630 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 364106007631 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 364106007632 ligand binding site [chemical binding]; other site 364106007633 NAD binding site [chemical binding]; other site 364106007634 catalytic site [active] 364106007635 homodimer interface [polypeptide binding]; other site 364106007636 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 364106007637 putative transporter; Provisional; Region: PRK12382 364106007638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106007639 putative substrate translocation pore; other site 364106007640 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 364106007641 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 364106007642 dimer interface [polypeptide binding]; other site 364106007643 active site 364106007644 Uncharacterized conserved protein [Function unknown]; Region: COG4121 364106007645 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 364106007646 YfcL protein; Region: YfcL; pfam08891 364106007647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 364106007648 hypothetical protein; Provisional; Region: PRK10621 364106007649 Predicted permeases [General function prediction only]; Region: COG0730 364106007650 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 364106007651 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 364106007652 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 364106007653 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 364106007654 Tetramer interface [polypeptide binding]; other site 364106007655 active site 364106007656 FMN-binding site [chemical binding]; other site 364106007657 HemK family putative methylases; Region: hemK_fam; TIGR00536 364106007658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106007659 S-adenosylmethionine binding site [chemical binding]; other site 364106007660 hypothetical protein; Provisional; Region: PRK04946 364106007661 Smr domain; Region: Smr; pfam01713 364106007662 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 364106007663 Fimbrial protein; Region: Fimbrial; cl01416 364106007664 Fimbrial protein; Region: Fimbrial; cl01416 364106007665 Fimbrial protein; Region: Fimbrial; cl01416 364106007666 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 364106007667 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 364106007668 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 364106007669 PapC N-terminal domain; Region: PapC_N; pfam13954 364106007670 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 364106007671 PapC C-terminal domain; Region: PapC_C; pfam13953 364106007672 Fimbrial protein; Region: Fimbrial; cl01416 364106007673 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 364106007674 catalytic core [active] 364106007675 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 364106007676 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 364106007677 substrate binding site [chemical binding]; other site 364106007678 oxyanion hole (OAH) forming residues; other site 364106007679 trimer interface [polypeptide binding]; other site 364106007680 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 364106007681 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 364106007682 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 364106007683 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 364106007684 dimer interface [polypeptide binding]; other site 364106007685 active site 364106007686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 364106007687 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 364106007688 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 364106007689 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 364106007690 possible prophage 364106007691 integrase; Provisional; Region: PRK09692 364106007692 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 364106007693 active site 364106007694 Int/Topo IB signature motif; other site 364106007695 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 364106007696 putative trimer interface [polypeptide binding]; other site 364106007697 putative CoA binding site [chemical binding]; other site 364106007698 Head binding; Region: Head_binding; pfam09008 364106007699 N terminal extension of bacteriophage endosialidase; Region: End_N_terminal; pfam12218 364106007700 Beta barrel domain of bacteriophage endosialidase; Region: End_beta_barrel; pfam12195 364106007701 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 364106007702 Asp-box motif; other site 364106007703 catalytic site [active] 364106007704 Catalytic domain of bacteriophage endosialidase; Region: End_tail_spike; pfam12219 364106007705 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 364106007706 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 364106007707 Prophage antirepressor [Transcription]; Region: COG3617 364106007708 Phage anti-repressor protein [Transcription]; Region: COG3561 364106007709 Arc-like DNA binding domain; Region: Arc; pfam03869 364106007710 Mnt; Region: mnt; PHA01513 364106007711 Mnt; Region: mnt; PHA01513 364106007712 Arc-like DNA binding domain; Region: Arc; pfam03869 364106007713 Regulatory protein Mnt; Region: Repressor_Mnt; pfam11423 364106007714 Toxin YafO, type II toxin-antitoxin system; Region: YafO_toxin; pfam13957 364106007715 Protein of unknown function (DUF2824); Region: DUF2824; pfam11039 364106007716 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 364106007717 P22 tail accessory factor; Region: P22_Tail-4; pfam11650 364106007718 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 364106007719 Phage terminase large subunit; Region: Terminase_3; pfam04466 364106007720 Protein of unknown function (DUF2560); Region: DUF2560; pfam10834 364106007721 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 364106007722 ORF11CD3 domain; Region: ORF11CD3; pfam10549 364106007723 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 364106007724 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 364106007725 N-acetyl-D-glucosamine binding site [chemical binding]; other site 364106007726 catalytic residue [active] 364106007727 phage holin, lambda family; Region: holin_lambda; TIGR01594 364106007728 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 364106007729 Phage NinH protein; Region: Phage_NinH; pfam06322 364106007730 Endodeoxyribonuclease RusA; Region: RusA; cl01885 364106007731 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 364106007732 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 364106007733 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 364106007734 Protein of unknown function (DUF2591); Region: DUF2591; pfam10765 364106007735 NINE Protein; Region: NinE; pfam05322 364106007736 NinB protein; Region: NinB; pfam05772 364106007737 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 364106007738 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 364106007739 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 364106007740 Walker A motif; other site 364106007741 ATP binding site [chemical binding]; other site 364106007742 Walker B motif; other site 364106007743 DNA binding loops [nucleotide binding] 364106007744 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 364106007745 Bacteriophage CII protein; Region: Phage_CII; pfam05269 364106007746 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 364106007747 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 364106007748 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 364106007749 non-specific DNA binding site [nucleotide binding]; other site 364106007750 salt bridge; other site 364106007751 sequence-specific DNA binding site [nucleotide binding]; other site 364106007752 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 364106007753 Catalytic site [active] 364106007754 Antirestriction protein Ral; Region: Ral; pfam11058 364106007755 Lambda Phage CIII; Region: Lambda_CIII; pfam02061 364106007756 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 364106007757 ERF superfamily; Region: ERF; pfam04404 364106007758 Protein of unknown function (DUF2856); Region: DUF2856; pfam11043 364106007759 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 364106007760 Protein of unknown function (DUF551); Region: DUF551; pfam04448 364106007761 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 364106007762 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 364106007763 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 364106007764 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106007765 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 364106007766 dimerization interface [polypeptide binding]; other site 364106007767 substrate binding pocket [chemical binding]; other site 364106007768 permease DsdX; Provisional; Region: PRK09921 364106007769 gluconate transporter; Region: gntP; TIGR00791 364106007770 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 364106007771 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 364106007772 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 364106007773 catalytic residue [active] 364106007774 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 364106007775 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106007776 putative substrate translocation pore; other site 364106007777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106007778 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 364106007779 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 364106007780 HlyD family secretion protein; Region: HlyD_3; pfam13437 364106007781 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 364106007782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106007783 active site 364106007784 phosphorylation site [posttranslational modification] 364106007785 intermolecular recognition site; other site 364106007786 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 364106007787 DNA binding residues [nucleotide binding] 364106007788 dimerization interface [polypeptide binding]; other site 364106007789 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 364106007790 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 364106007791 substrate binding pocket [chemical binding]; other site 364106007792 membrane-bound complex binding site; other site 364106007793 hinge residues; other site 364106007794 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 364106007795 substrate binding pocket [chemical binding]; other site 364106007796 membrane-bound complex binding site; other site 364106007797 hinge residues; other site 364106007798 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 364106007799 dimer interface [polypeptide binding]; other site 364106007800 phosphorylation site [posttranslational modification] 364106007801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106007802 ATP binding site [chemical binding]; other site 364106007803 Mg2+ binding site [ion binding]; other site 364106007804 G-X-G motif; other site 364106007805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106007806 active site 364106007807 phosphorylation site [posttranslational modification] 364106007808 intermolecular recognition site; other site 364106007809 dimerization interface [polypeptide binding]; other site 364106007810 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 364106007811 putative binding surface; other site 364106007812 active site 364106007813 putative CoA-transferase; Provisional; Region: PRK11430 364106007814 CoA-transferase family III; Region: CoA_transf_3; pfam02515 364106007815 putative transporter YfdV; Provisional; Region: PRK09903 364106007816 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 364106007817 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 364106007818 PYR/PP interface [polypeptide binding]; other site 364106007819 dimer interface [polypeptide binding]; other site 364106007820 TPP binding site [chemical binding]; other site 364106007821 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 364106007822 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 364106007823 TPP-binding site; other site 364106007824 dimer interface [polypeptide binding]; other site 364106007825 formyl-coenzyme A transferase; Provisional; Region: PRK05398 364106007826 CoA-transferase family III; Region: CoA_transf_3; pfam02515 364106007827 hypothetical protein; Provisional; Region: PRK10316 364106007828 YfdX protein; Region: YfdX; pfam10938 364106007829 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 364106007830 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 364106007831 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 364106007832 putative acyl-acceptor binding pocket; other site 364106007833 aminotransferase; Validated; Region: PRK08175 364106007834 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 364106007835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106007836 homodimer interface [polypeptide binding]; other site 364106007837 catalytic residue [active] 364106007838 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 364106007839 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 364106007840 GAF domain; Region: GAF; cl17456 364106007841 Histidine kinase; Region: His_kinase; pfam06580 364106007842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106007843 ATP binding site [chemical binding]; other site 364106007844 Mg2+ binding site [ion binding]; other site 364106007845 G-X-G motif; other site 364106007846 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 364106007847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106007848 active site 364106007849 phosphorylation site [posttranslational modification] 364106007850 intermolecular recognition site; other site 364106007851 dimerization interface [polypeptide binding]; other site 364106007852 LytTr DNA-binding domain; Region: LytTR; pfam04397 364106007853 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 364106007854 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106007855 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 364106007856 dimerization domain swap beta strand [polypeptide binding]; other site 364106007857 regulatory protein interface [polypeptide binding]; other site 364106007858 active site 364106007859 regulatory phosphorylation site [posttranslational modification]; other site 364106007860 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 364106007861 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 364106007862 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 364106007863 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 364106007864 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 364106007865 active site 364106007866 phosphorylation site [posttranslational modification] 364106007867 exoaminopeptidase; Provisional; Region: PRK09961 364106007868 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 364106007869 oligomer interface [polypeptide binding]; other site 364106007870 active site 364106007871 metal binding site [ion binding]; metal-binding site 364106007872 aminopeptidase; Provisional; Region: PRK09795 364106007873 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 364106007874 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 364106007875 active site 364106007876 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 364106007877 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 364106007878 active site 364106007879 P-loop; other site 364106007880 phosphorylation site [posttranslational modification] 364106007881 glucokinase, proteobacterial type; Region: glk; TIGR00749 364106007882 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 364106007883 nucleotide binding site [chemical binding]; other site 364106007884 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 364106007885 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 364106007886 Cl- selectivity filter; other site 364106007887 Cl- binding residues [ion binding]; other site 364106007888 pore gating glutamate residue; other site 364106007889 dimer interface [polypeptide binding]; other site 364106007890 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 364106007891 manganese transport protein MntH; Reviewed; Region: PRK00701 364106007892 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 364106007893 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 364106007894 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 364106007895 Nucleoside recognition; Region: Gate; pfam07670 364106007896 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 364106007897 MASE1; Region: MASE1; pfam05231 364106007898 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 364106007899 diguanylate cyclase; Region: GGDEF; smart00267 364106007900 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 364106007901 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 364106007902 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 364106007903 salt bridge; other site 364106007904 non-specific DNA binding site [nucleotide binding]; other site 364106007905 sequence-specific DNA binding site [nucleotide binding]; other site 364106007906 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 364106007907 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 364106007908 active site 364106007909 HIGH motif; other site 364106007910 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 364106007911 active site 364106007912 KMSKS motif; other site 364106007913 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 364106007914 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106007915 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 364106007916 putative dimerization interface [polypeptide binding]; other site 364106007917 putative substrate binding pocket [chemical binding]; other site 364106007918 XapX domain; Region: XapX; TIGR03510 364106007919 nucleoside transporter; Region: 2A0110; TIGR00889 364106007920 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106007921 putative substrate translocation pore; other site 364106007922 purine nucleoside phosphorylase; Provisional; Region: PRK08202 364106007923 Transcriptional regulator [Transcription]; Region: LysR; COG0583 364106007924 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106007925 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 364106007926 putative dimerization interface [polypeptide binding]; other site 364106007927 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 364106007928 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 364106007929 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 364106007930 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 364106007931 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 364106007932 nucleotide binding pocket [chemical binding]; other site 364106007933 K-X-D-G motif; other site 364106007934 catalytic site [active] 364106007935 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 364106007936 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 364106007937 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 364106007938 Dimer interface [polypeptide binding]; other site 364106007939 BRCT sequence motif; other site 364106007940 cell division protein ZipA; Provisional; Region: PRK03427 364106007941 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 364106007942 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 364106007943 FtsZ protein binding site [polypeptide binding]; other site 364106007944 putative sulfate transport protein CysZ; Validated; Region: PRK04949 364106007945 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 364106007946 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 364106007947 dimer interface [polypeptide binding]; other site 364106007948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106007949 catalytic residue [active] 364106007950 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 364106007951 dimerization domain swap beta strand [polypeptide binding]; other site 364106007952 regulatory protein interface [polypeptide binding]; other site 364106007953 active site 364106007954 regulatory phosphorylation site [posttranslational modification]; other site 364106007955 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 364106007956 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 364106007957 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 364106007958 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 364106007959 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 364106007960 HPr interaction site; other site 364106007961 glycerol kinase (GK) interaction site [polypeptide binding]; other site 364106007962 active site 364106007963 phosphorylation site [posttranslational modification] 364106007964 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 364106007965 dimer interface [polypeptide binding]; other site 364106007966 pyridoxamine kinase; Validated; Region: PRK05756 364106007967 pyridoxal binding site [chemical binding]; other site 364106007968 ATP binding site [chemical binding]; other site 364106007969 hypothetical protein; Provisional; Region: PRK10318 364106007970 cysteine synthase B; Region: cysM; TIGR01138 364106007971 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 364106007972 dimer interface [polypeptide binding]; other site 364106007973 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106007974 catalytic residue [active] 364106007975 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 364106007976 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 364106007977 Walker A/P-loop; other site 364106007978 ATP binding site [chemical binding]; other site 364106007979 Q-loop/lid; other site 364106007980 ABC transporter signature motif; other site 364106007981 Walker B; other site 364106007982 D-loop; other site 364106007983 H-loop/switch region; other site 364106007984 TOBE-like domain; Region: TOBE_3; pfam12857 364106007985 sulfate transport protein; Provisional; Region: cysT; CHL00187 364106007986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106007987 dimer interface [polypeptide binding]; other site 364106007988 conserved gate region; other site 364106007989 putative PBP binding loops; other site 364106007990 ABC-ATPase subunit interface; other site 364106007991 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 364106007992 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106007993 dimer interface [polypeptide binding]; other site 364106007994 conserved gate region; other site 364106007995 putative PBP binding loops; other site 364106007996 ABC-ATPase subunit interface; other site 364106007997 thiosulfate transporter subunit; Provisional; Region: PRK10852 364106007998 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 364106007999 short chain dehydrogenase; Provisional; Region: PRK08226 364106008000 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 364106008001 NAD binding site [chemical binding]; other site 364106008002 homotetramer interface [polypeptide binding]; other site 364106008003 homodimer interface [polypeptide binding]; other site 364106008004 active site 364106008005 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 364106008006 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 364106008007 putative active site [active] 364106008008 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 364106008009 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 364106008010 active site turn [active] 364106008011 phosphorylation site [posttranslational modification] 364106008012 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 364106008013 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 364106008014 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 364106008015 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 364106008016 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 364106008017 putative acetyltransferase; Provisional; Region: PRK03624 364106008018 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 364106008019 Coenzyme A binding pocket [chemical binding]; other site 364106008020 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 364106008021 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 364106008022 active site 364106008023 metal binding site [ion binding]; metal-binding site 364106008024 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 364106008025 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 364106008026 transcriptional regulator EutR; Provisional; Region: PRK10130 364106008027 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106008028 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106008029 carboxysome structural protein EutK; Provisional; Region: PRK15466 364106008030 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 364106008031 Hexamer interface [polypeptide binding]; other site 364106008032 Hexagonal pore residue; other site 364106008033 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 364106008034 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 364106008035 putative hexamer interface [polypeptide binding]; other site 364106008036 putative hexagonal pore; other site 364106008037 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 364106008038 putative hexamer interface [polypeptide binding]; other site 364106008039 putative hexagonal pore; other site 364106008040 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 364106008041 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 364106008042 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 364106008043 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 364106008044 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 364106008045 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 364106008046 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 364106008047 active site 364106008048 metal binding site [ion binding]; metal-binding site 364106008049 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 364106008050 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 364106008051 nucleotide binding site [chemical binding]; other site 364106008052 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 364106008053 putative catalytic cysteine [active] 364106008054 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 364106008055 Hexamer/Pentamer interface [polypeptide binding]; other site 364106008056 central pore; other site 364106008057 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 364106008058 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 364106008059 Hexamer interface [polypeptide binding]; other site 364106008060 Hexagonal pore residue; other site 364106008061 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 364106008062 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 364106008063 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 364106008064 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 364106008065 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 364106008066 G1 box; other site 364106008067 GTP/Mg2+ binding site [chemical binding]; other site 364106008068 G2 box; other site 364106008069 Switch I region; other site 364106008070 G3 box; other site 364106008071 Switch II region; other site 364106008072 G4 box; other site 364106008073 G5 box; other site 364106008074 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 364106008075 putative hexamer interface [polypeptide binding]; other site 364106008076 putative hexagonal pore; other site 364106008077 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 364106008078 Malic enzyme, N-terminal domain; Region: malic; pfam00390 364106008079 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 364106008080 putative NAD(P) binding site [chemical binding]; other site 364106008081 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 364106008082 transaldolase-like protein; Provisional; Region: PTZ00411 364106008083 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 364106008084 active site 364106008085 dimer interface [polypeptide binding]; other site 364106008086 catalytic residue [active] 364106008087 transketolase; Reviewed; Region: PRK12753 364106008088 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 364106008089 TPP-binding site [chemical binding]; other site 364106008090 dimer interface [polypeptide binding]; other site 364106008091 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 364106008092 PYR/PP interface [polypeptide binding]; other site 364106008093 dimer interface [polypeptide binding]; other site 364106008094 TPP binding site [chemical binding]; other site 364106008095 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 364106008096 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 364106008097 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 364106008098 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 364106008099 dimer interface [polypeptide binding]; other site 364106008100 ADP-ribose binding site [chemical binding]; other site 364106008101 active site 364106008102 nudix motif; other site 364106008103 metal binding site [ion binding]; metal-binding site 364106008104 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 364106008105 4Fe-4S binding domain; Region: Fer4; pfam00037 364106008106 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 364106008107 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 364106008108 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 364106008109 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 364106008110 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 364106008111 dimerization interface [polypeptide binding]; other site 364106008112 Histidine kinase; Region: HisKA_3; pfam07730 364106008113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106008114 ATP binding site [chemical binding]; other site 364106008115 Mg2+ binding site [ion binding]; other site 364106008116 G-X-G motif; other site 364106008117 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 364106008118 Protein export membrane protein; Region: SecD_SecF; cl14618 364106008119 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 364106008120 ArsC family; Region: ArsC; pfam03960 364106008121 putative catalytic residues [active] 364106008122 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 364106008123 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 364106008124 metal binding site [ion binding]; metal-binding site 364106008125 dimer interface [polypeptide binding]; other site 364106008126 hypothetical protein; Provisional; Region: PRK13664 364106008127 putative hydrolase; Provisional; Region: PRK11460 364106008128 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 364106008129 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 364106008130 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 364106008131 Helicase; Region: Helicase_RecD; pfam05127 364106008132 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 364106008133 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 364106008134 Predicted metalloprotease [General function prediction only]; Region: COG2321 364106008135 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 364106008136 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 364106008137 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 364106008138 ATP binding site [chemical binding]; other site 364106008139 active site 364106008140 substrate binding site [chemical binding]; other site 364106008141 lipoprotein; Provisional; Region: PRK11679 364106008142 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 364106008143 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 364106008144 dihydrodipicolinate synthase; Region: dapA; TIGR00674 364106008145 dimer interface [polypeptide binding]; other site 364106008146 active site 364106008147 catalytic residue [active] 364106008148 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 364106008149 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 364106008150 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 364106008151 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 364106008152 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 364106008153 catalytic triad [active] 364106008154 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 364106008155 Domain of unknown function DUF20; Region: UPF0118; pfam01594 364106008156 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 364106008157 Peptidase family M48; Region: Peptidase_M48; cl12018 364106008158 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 364106008159 ArsC family; Region: ArsC; pfam03960 364106008160 catalytic residues [active] 364106008161 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 364106008162 DNA replication initiation factor; Provisional; Region: PRK08084 364106008163 uracil transporter; Provisional; Region: PRK10720 364106008164 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 364106008165 active site 364106008166 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 364106008167 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 364106008168 dimerization interface [polypeptide binding]; other site 364106008169 putative ATP binding site [chemical binding]; other site 364106008170 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 364106008171 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 364106008172 active site 364106008173 substrate binding site [chemical binding]; other site 364106008174 cosubstrate binding site; other site 364106008175 catalytic site [active] 364106008176 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 364106008177 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 364106008178 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 364106008179 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 364106008180 domain interface [polypeptide binding]; other site 364106008181 active site 364106008182 catalytic site [active] 364106008183 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 364106008184 putative active site [active] 364106008185 catalytic site [active] 364106008186 exopolyphosphatase; Provisional; Region: PRK10854 364106008187 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 364106008188 MASE1; Region: MASE1; pfam05231 364106008189 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 364106008190 diguanylate cyclase; Region: GGDEF; smart00267 364106008191 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 364106008192 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 364106008193 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 364106008194 GMP synthase; Reviewed; Region: guaA; PRK00074 364106008195 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 364106008196 AMP/PPi binding site [chemical binding]; other site 364106008197 candidate oxyanion hole; other site 364106008198 catalytic triad [active] 364106008199 potential glutamine specificity residues [chemical binding]; other site 364106008200 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 364106008201 ATP Binding subdomain [chemical binding]; other site 364106008202 Ligand Binding sites [chemical binding]; other site 364106008203 Dimerization subdomain; other site 364106008204 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 364106008205 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 364106008206 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 364106008207 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 364106008208 active site 364106008209 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 364106008210 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 364106008211 generic binding surface II; other site 364106008212 generic binding surface I; other site 364106008213 RatA-like protein; Provisional; Region: PRK15316 364106008214 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 364106008215 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 364106008216 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 364106008217 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 364106008218 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 364106008219 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 364106008220 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 364106008221 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 364106008222 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 364106008223 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 364106008224 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 364106008225 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 364106008226 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 364106008227 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 364106008228 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 364106008229 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 364106008230 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 364106008231 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 364106008232 intimin-like protein SinH; Provisional; Region: PRK15318 364106008233 intimin-like protein SinH; Provisional; Region: PRK15318 364106008234 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 364106008235 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 364106008236 GTP-binding protein Der; Reviewed; Region: PRK00093 364106008237 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 364106008238 G1 box; other site 364106008239 GTP/Mg2+ binding site [chemical binding]; other site 364106008240 Switch I region; other site 364106008241 G2 box; other site 364106008242 Switch II region; other site 364106008243 G3 box; other site 364106008244 G4 box; other site 364106008245 G5 box; other site 364106008246 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 364106008247 G1 box; other site 364106008248 GTP/Mg2+ binding site [chemical binding]; other site 364106008249 Switch I region; other site 364106008250 G2 box; other site 364106008251 G3 box; other site 364106008252 Switch II region; other site 364106008253 G4 box; other site 364106008254 G5 box; other site 364106008255 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 364106008256 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 364106008257 Trp docking motif [polypeptide binding]; other site 364106008258 active site 364106008259 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 364106008260 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 364106008261 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 364106008262 dimer interface [polypeptide binding]; other site 364106008263 motif 1; other site 364106008264 active site 364106008265 motif 2; other site 364106008266 motif 3; other site 364106008267 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 364106008268 anticodon binding site; other site 364106008269 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 364106008270 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 364106008271 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 364106008272 cytoskeletal protein RodZ; Provisional; Region: PRK10856 364106008273 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 364106008274 non-specific DNA binding site [nucleotide binding]; other site 364106008275 salt bridge; other site 364106008276 sequence-specific DNA binding site [nucleotide binding]; other site 364106008277 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 364106008278 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 364106008279 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 364106008280 FeS/SAM binding site; other site 364106008281 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 364106008282 active site 364106008283 multimer interface [polypeptide binding]; other site 364106008284 penicillin-binding protein 1C; Provisional; Region: PRK11240 364106008285 Transglycosylase; Region: Transgly; pfam00912 364106008286 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 364106008287 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 364106008288 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 364106008289 MG2 domain; Region: A2M_N; pfam01835 364106008290 Alpha-2-macroglobulin family; Region: A2M; pfam00207 364106008291 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 364106008292 surface patch; other site 364106008293 thioester region; other site 364106008294 specificity defining residues; other site 364106008295 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 364106008296 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 364106008297 active site residue [active] 364106008298 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 364106008299 active site residue [active] 364106008300 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 364106008301 aminopeptidase B; Provisional; Region: PRK05015 364106008302 Peptidase; Region: DUF3663; pfam12404 364106008303 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 364106008304 interface (dimer of trimers) [polypeptide binding]; other site 364106008305 Substrate-binding/catalytic site; other site 364106008306 Zn-binding sites [ion binding]; other site 364106008307 hypothetical protein; Provisional; Region: PRK10721 364106008308 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 364106008309 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 364106008310 catalytic loop [active] 364106008311 iron binding site [ion binding]; other site 364106008312 chaperone protein HscA; Provisional; Region: hscA; PRK05183 364106008313 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 364106008314 nucleotide binding site [chemical binding]; other site 364106008315 putative NEF/HSP70 interaction site [polypeptide binding]; other site 364106008316 SBD interface [polypeptide binding]; other site 364106008317 co-chaperone HscB; Provisional; Region: hscB; PRK05014 364106008318 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 364106008319 HSP70 interaction site [polypeptide binding]; other site 364106008320 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 364106008321 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 364106008322 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 364106008323 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 364106008324 trimerization site [polypeptide binding]; other site 364106008325 active site 364106008326 cysteine desulfurase; Provisional; Region: PRK14012 364106008327 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 364106008328 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 364106008329 catalytic residue [active] 364106008330 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 364106008331 Rrf2 family protein; Region: rrf2_super; TIGR00738 364106008332 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 364106008333 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 364106008334 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 364106008335 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 364106008336 active site 364106008337 dimerization interface [polypeptide binding]; other site 364106008338 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 364106008339 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 364106008340 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 364106008341 PRD domain; Region: PRD; pfam00874 364106008342 PRD domain; Region: PRD; pfam00874 364106008343 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 364106008344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106008345 putative substrate translocation pore; other site 364106008346 Predicted membrane protein [Function unknown]; Region: COG2259 364106008347 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 364106008348 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 364106008349 active site 364106008350 catalytic residues [active] 364106008351 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 364106008352 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 364106008353 putative NAD(P) binding site [chemical binding]; other site 364106008354 catalytic Zn binding site [ion binding]; other site 364106008355 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 364106008356 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 364106008357 TM-ABC transporter signature motif; other site 364106008358 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 364106008359 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 364106008360 Walker A/P-loop; other site 364106008361 ATP binding site [chemical binding]; other site 364106008362 Q-loop/lid; other site 364106008363 ABC transporter signature motif; other site 364106008364 Walker B; other site 364106008365 D-loop; other site 364106008366 H-loop/switch region; other site 364106008367 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 364106008368 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 364106008369 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 364106008370 ligand binding site [chemical binding]; other site 364106008371 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 364106008372 TPR motif; other site 364106008373 Tetratricopeptide repeat; Region: TPR_16; pfam13432 364106008374 binding surface 364106008375 TPR repeat; Region: TPR_11; pfam13414 364106008376 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 364106008377 TPR motif; other site 364106008378 binding surface 364106008379 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 364106008380 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 364106008381 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 364106008382 nucleotide binding site [chemical binding]; other site 364106008383 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 364106008384 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 364106008385 dimer interface [polypeptide binding]; other site 364106008386 active site 364106008387 glycine-pyridoxal phosphate binding site [chemical binding]; other site 364106008388 folate binding site [chemical binding]; other site 364106008389 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 364106008390 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 364106008391 heme-binding site [chemical binding]; other site 364106008392 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 364106008393 FAD binding pocket [chemical binding]; other site 364106008394 FAD binding motif [chemical binding]; other site 364106008395 phosphate binding motif [ion binding]; other site 364106008396 beta-alpha-beta structure motif; other site 364106008397 NAD binding pocket [chemical binding]; other site 364106008398 Heme binding pocket [chemical binding]; other site 364106008399 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 364106008400 Nitrogen regulatory protein P-II; Region: P-II; smart00938 364106008401 response regulator GlrR; Provisional; Region: PRK15115 364106008402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106008403 active site 364106008404 phosphorylation site [posttranslational modification] 364106008405 intermolecular recognition site; other site 364106008406 dimerization interface [polypeptide binding]; other site 364106008407 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106008408 Walker A motif; other site 364106008409 ATP binding site [chemical binding]; other site 364106008410 Walker B motif; other site 364106008411 arginine finger; other site 364106008412 hypothetical protein; Provisional; Region: PRK10722 364106008413 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 364106008414 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 364106008415 dimer interface [polypeptide binding]; other site 364106008416 phosphorylation site [posttranslational modification] 364106008417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106008418 ATP binding site [chemical binding]; other site 364106008419 Mg2+ binding site [ion binding]; other site 364106008420 G-X-G motif; other site 364106008421 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 364106008422 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 364106008423 dimerization interface [polypeptide binding]; other site 364106008424 ATP binding site [chemical binding]; other site 364106008425 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 364106008426 dimerization interface [polypeptide binding]; other site 364106008427 ATP binding site [chemical binding]; other site 364106008428 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 364106008429 putative active site [active] 364106008430 catalytic triad [active] 364106008431 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 364106008432 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 364106008433 substrate binding pocket [chemical binding]; other site 364106008434 membrane-bound complex binding site; other site 364106008435 hinge residues; other site 364106008436 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 364106008437 N-acetyl-D-glucosamine binding site [chemical binding]; other site 364106008438 catalytic residue [active] 364106008439 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 364106008440 nucleoside/Zn binding site; other site 364106008441 dimer interface [polypeptide binding]; other site 364106008442 catalytic motif [active] 364106008443 hypothetical protein; Provisional; Region: PRK11590 364106008444 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 364106008445 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 364106008446 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 364106008447 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 364106008448 putative active site [active] 364106008449 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 364106008450 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 364106008451 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 364106008452 active site 364106008453 hydrophilic channel; other site 364106008454 dimerization interface [polypeptide binding]; other site 364106008455 catalytic residues [active] 364106008456 active site lid [active] 364106008457 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 364106008458 Recombination protein O N terminal; Region: RecO_N; pfam11967 364106008459 Recombination protein O C terminal; Region: RecO_C; pfam02565 364106008460 GTPase Era; Reviewed; Region: era; PRK00089 364106008461 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 364106008462 G1 box; other site 364106008463 GTP/Mg2+ binding site [chemical binding]; other site 364106008464 Switch I region; other site 364106008465 G2 box; other site 364106008466 Switch II region; other site 364106008467 G3 box; other site 364106008468 G4 box; other site 364106008469 G5 box; other site 364106008470 KH domain; Region: KH_2; pfam07650 364106008471 ribonuclease III; Reviewed; Region: rnc; PRK00102 364106008472 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 364106008473 dimerization interface [polypeptide binding]; other site 364106008474 active site 364106008475 metal binding site [ion binding]; metal-binding site 364106008476 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 364106008477 dsRNA binding site [nucleotide binding]; other site 364106008478 signal peptidase I; Provisional; Region: PRK10861 364106008479 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 364106008480 Catalytic site [active] 364106008481 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 364106008482 GTP-binding protein LepA; Provisional; Region: PRK05433 364106008483 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 364106008484 G1 box; other site 364106008485 putative GEF interaction site [polypeptide binding]; other site 364106008486 GTP/Mg2+ binding site [chemical binding]; other site 364106008487 Switch I region; other site 364106008488 G2 box; other site 364106008489 G3 box; other site 364106008490 Switch II region; other site 364106008491 G4 box; other site 364106008492 G5 box; other site 364106008493 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 364106008494 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 364106008495 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 364106008496 SoxR reducing system protein RseC; Provisional; Region: PRK10862 364106008497 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 364106008498 anti-sigma E factor; Provisional; Region: rseB; PRK09455 364106008499 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 364106008500 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 364106008501 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 364106008502 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 364106008503 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 364106008504 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 364106008505 DNA binding residues [nucleotide binding] 364106008506 L-aspartate oxidase; Provisional; Region: PRK09077 364106008507 L-aspartate oxidase; Provisional; Region: PRK06175 364106008508 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 364106008509 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 364106008510 Methyltransferase domain; Region: Methyltransf_26; pfam13659 364106008511 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 364106008512 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 364106008513 ATP binding site [chemical binding]; other site 364106008514 Mg++ binding site [ion binding]; other site 364106008515 motif III; other site 364106008516 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 364106008517 nucleotide binding region [chemical binding]; other site 364106008518 ATP-binding site [chemical binding]; other site 364106008519 Transcriptional regulator [Transcription]; Region: LysR; COG0583 364106008520 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106008521 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 364106008522 dimerization interface [polypeptide binding]; other site 364106008523 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 364106008524 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 364106008525 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 364106008526 ligand binding site [chemical binding]; other site 364106008527 active site 364106008528 UGI interface [polypeptide binding]; other site 364106008529 catalytic site [active] 364106008530 putative methyltransferase; Provisional; Region: PRK10864 364106008531 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 364106008532 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 364106008533 thioredoxin 2; Provisional; Region: PRK10996 364106008534 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 364106008535 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 364106008536 catalytic residues [active] 364106008537 Uncharacterized conserved protein [Function unknown]; Region: COG3148 364106008538 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 364106008539 CoA binding domain; Region: CoA_binding_2; pfam13380 364106008540 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 364106008541 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 364106008542 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 364106008543 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 364106008544 Coenzyme A binding pocket [chemical binding]; other site 364106008545 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 364106008546 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 364106008547 domain interface [polypeptide binding]; other site 364106008548 putative active site [active] 364106008549 catalytic site [active] 364106008550 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 364106008551 domain interface [polypeptide binding]; other site 364106008552 putative active site [active] 364106008553 catalytic site [active] 364106008554 lipoprotein; Provisional; Region: PRK10759 364106008555 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 364106008556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106008557 putative substrate translocation pore; other site 364106008558 Transposase; Region: DEDD_Tnp_IS110; pfam01548 364106008559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 364106008560 HTH-like domain; Region: HTH_21; pfam13276 364106008561 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 364106008562 Integrase core domain; Region: rve; pfam00665 364106008563 Integrase core domain; Region: rve_2; pfam13333 364106008564 protein disaggregation chaperone; Provisional; Region: PRK10865 364106008565 Clp amino terminal domain; Region: Clp_N; pfam02861 364106008566 Clp amino terminal domain; Region: Clp_N; pfam02861 364106008567 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106008568 Walker A motif; other site 364106008569 ATP binding site [chemical binding]; other site 364106008570 Walker B motif; other site 364106008571 arginine finger; other site 364106008572 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106008573 Walker A motif; other site 364106008574 ATP binding site [chemical binding]; other site 364106008575 Walker B motif; other site 364106008576 arginine finger; other site 364106008577 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 364106008578 hypothetical protein; Provisional; Region: PRK10723 364106008579 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 364106008580 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 364106008581 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 364106008582 RNA binding surface [nucleotide binding]; other site 364106008583 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 364106008584 active site 364106008585 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 364106008586 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 364106008587 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 364106008588 30S subunit binding site; other site 364106008589 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 364106008590 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 364106008591 Prephenate dehydratase; Region: PDT; pfam00800 364106008592 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 364106008593 putative L-Phe binding site [chemical binding]; other site 364106008594 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 364106008595 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 364106008596 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 364106008597 prephenate dehydrogenase; Validated; Region: PRK08507 364106008598 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 364106008599 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 364106008600 lipoprotein; Provisional; Region: PRK11443 364106008601 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 364106008602 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 364106008603 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 364106008604 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 364106008605 metal binding site [ion binding]; metal-binding site 364106008606 active site 364106008607 I-site; other site 364106008608 putative outer membrane lipoprotein; Provisional; Region: PRK09967 364106008609 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 364106008610 ligand binding site [chemical binding]; other site 364106008611 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 364106008612 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 364106008613 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 364106008614 RimM N-terminal domain; Region: RimM; pfam01782 364106008615 PRC-barrel domain; Region: PRC; pfam05239 364106008616 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 364106008617 signal recognition particle protein; Provisional; Region: PRK10867 364106008618 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 364106008619 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 364106008620 P loop; other site 364106008621 GTP binding site [chemical binding]; other site 364106008622 Signal peptide binding domain; Region: SRP_SPB; pfam02978 364106008623 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 364106008624 hypothetical protein; Provisional; Region: PRK11573 364106008625 Domain of unknown function DUF21; Region: DUF21; pfam01595 364106008626 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 364106008627 Transporter associated domain; Region: CorC_HlyC; smart01091 364106008628 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 364106008629 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 364106008630 dimer interface [polypeptide binding]; other site 364106008631 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 364106008632 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 364106008633 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 364106008634 recombination and repair protein; Provisional; Region: PRK10869 364106008635 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 364106008636 Walker A/P-loop; other site 364106008637 ATP binding site [chemical binding]; other site 364106008638 Q-loop/lid; other site 364106008639 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 364106008640 Q-loop/lid; other site 364106008641 ABC transporter signature motif; other site 364106008642 Walker B; other site 364106008643 D-loop; other site 364106008644 H-loop/switch region; other site 364106008645 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 364106008646 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 364106008647 hypothetical protein; Validated; Region: PRK01777 364106008648 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 364106008649 putative coenzyme Q binding site [chemical binding]; other site 364106008650 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 364106008651 SmpB-tmRNA interface; other site 364106008652 possible prophage 364106008653 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 364106008654 GIY-YIG motif/motif A; other site 364106008655 putative active site [active] 364106008656 putative metal binding site [ion binding]; other site 364106008657 Uncharacterized conserved protein [Function unknown]; Region: COG1479 364106008658 Protein of unknown function DUF262; Region: DUF262; pfam03235 364106008659 Protein of unknown function DUF262; Region: DUF262; pfam03235 364106008660 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 364106008661 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 364106008662 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 364106008663 Phage Tail Collar Domain; Region: Collar; pfam07484 364106008664 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3778 364106008665 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 364106008666 Phage protein GP46; Region: GP46; pfam07409 364106008667 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 364106008668 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; pfam06890 364106008669 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 364106008670 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 364106008671 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 364106008672 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 364106008673 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 364106008674 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 364106008675 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 364106008676 Phage tail tube protein; Region: Tail_tube; pfam10618 364106008677 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 364106008678 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 364106008679 Protein of unknown function (DUF2635); Region: DUF2635; pfam10948 364106008680 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 364106008681 [benzylsuccinate synthase]-activating enzyme; Region: rSAM_BssD; TIGR04003 364106008682 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 364106008683 oligomerization interface [polypeptide binding]; other site 364106008684 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 364106008685 Phage capsid family; Region: Phage_capsid; pfam05065 364106008686 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 364106008687 Phage-related protein [Function unknown]; Region: COG4695 364106008688 Phage portal protein; Region: Phage_portal; pfam04860 364106008689 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 364106008690 Phage terminase, small subunit; Region: Terminase_4; pfam05119 364106008691 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 364106008692 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 364106008693 active site 364106008694 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 364106008695 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 364106008696 N-acetyl-D-glucosamine binding site [chemical binding]; other site 364106008697 catalytic residue [active] 364106008698 Antitermination protein; Region: Antiterm; pfam03589 364106008699 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 364106008700 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 364106008701 Zn binding sites [ion binding]; other site 364106008702 Antitermination protein; Region: Antiterm; pfam03589 364106008703 Protein of unknown function (DUF968); Region: DUF968; pfam06147 364106008704 KilA-N domain; Region: KilA-N; pfam04383 364106008705 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 364106008706 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 364106008707 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 364106008708 PerC transcriptional activator; Region: PerC; pfam06069 364106008709 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 364106008710 DNA-binding site [nucleotide binding]; DNA binding site 364106008711 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 364106008712 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 364106008713 Catalytic site [active] 364106008714 Uncharacterized conserved protein [Function unknown]; Region: COG5532 364106008715 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 364106008716 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 364106008717 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 364106008718 Int/Topo IB signature motif; other site 364106008719 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 364106008720 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 364106008721 substrate binding pocket [chemical binding]; other site 364106008722 active site 364106008723 iron coordination sites [ion binding]; other site 364106008724 Predicted dehydrogenase [General function prediction only]; Region: COG0579 364106008725 hydroxyglutarate oxidase; Provisional; Region: PRK11728 364106008726 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 364106008727 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 364106008728 tetramerization interface [polypeptide binding]; other site 364106008729 NAD(P) binding site [chemical binding]; other site 364106008730 catalytic residues [active] 364106008731 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 364106008732 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 364106008733 inhibitor-cofactor binding pocket; inhibition site 364106008734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106008735 catalytic residue [active] 364106008736 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 364106008737 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 364106008738 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 364106008739 DNA-binding site [nucleotide binding]; DNA binding site 364106008740 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 364106008741 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 364106008742 bacterial OsmY and nodulation domain; Region: BON; smart00749 364106008743 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 364106008744 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 364106008745 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 364106008746 dimerization interface [polypeptide binding]; other site 364106008747 putative DNA binding site [nucleotide binding]; other site 364106008748 Transcriptional regulators [Transcription]; Region: MarR; COG1846 364106008749 putative Zn2+ binding site [ion binding]; other site 364106008750 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 364106008751 active site residue [active] 364106008752 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 364106008753 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 364106008754 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 364106008755 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 364106008756 hypothetical protein; Provisional; Region: PRK10556 364106008757 hypothetical protein; Provisional; Region: PRK10132 364106008758 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 364106008759 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 364106008760 DNA-binding site [nucleotide binding]; DNA binding site 364106008761 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 364106008762 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106008763 homodimer interface [polypeptide binding]; other site 364106008764 catalytic residue [active] 364106008765 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 364106008766 Uncharacterized conserved protein [Function unknown]; Region: COG2128 364106008767 DNA-directed RNA polymerase II subunit 7; Provisional; Region: PTZ00162 364106008768 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 364106008769 catalytic residues [active] 364106008770 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 364106008771 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 364106008772 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 364106008773 Class I ribonucleotide reductase; Region: RNR_I; cd01679 364106008774 active site 364106008775 dimer interface [polypeptide binding]; other site 364106008776 catalytic residues [active] 364106008777 effector binding site; other site 364106008778 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 364106008779 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 364106008780 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 364106008781 dimer interface [polypeptide binding]; other site 364106008782 putative radical transfer pathway; other site 364106008783 diiron center [ion binding]; other site 364106008784 tyrosyl radical; other site 364106008785 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 364106008786 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 364106008787 Walker A/P-loop; other site 364106008788 ATP binding site [chemical binding]; other site 364106008789 Q-loop/lid; other site 364106008790 ABC transporter signature motif; other site 364106008791 Walker B; other site 364106008792 D-loop; other site 364106008793 H-loop/switch region; other site 364106008794 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 364106008795 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 364106008796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106008797 dimer interface [polypeptide binding]; other site 364106008798 conserved gate region; other site 364106008799 putative PBP binding loops; other site 364106008800 ABC-ATPase subunit interface; other site 364106008801 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 364106008802 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 364106008803 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 364106008804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106008805 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 364106008806 putative L-valine exporter; Provisional; Region: PRK10408 364106008807 transcriptional repressor MprA; Provisional; Region: PRK10870 364106008808 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 364106008809 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 364106008810 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 364106008811 HlyD family secretion protein; Region: HlyD_3; pfam13437 364106008812 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 364106008813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106008814 putative substrate translocation pore; other site 364106008815 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106008816 RNA ligase; Region: RNA_ligase; pfam09414 364106008817 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 364106008818 Zn2+ binding site [ion binding]; other site 364106008819 Mg2+ binding site [ion binding]; other site 364106008820 AAA domain; Region: AAA_33; pfam13671 364106008821 S-ribosylhomocysteinase; Provisional; Region: PRK02260 364106008822 glutamate--cysteine ligase; Provisional; Region: PRK02107 364106008823 Predicted membrane protein [Function unknown]; Region: COG1238 364106008824 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 364106008825 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 364106008826 motif II; other site 364106008827 carbon storage regulator; Provisional; Region: PRK01712 364106008828 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 364106008829 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 364106008830 motif 1; other site 364106008831 active site 364106008832 motif 2; other site 364106008833 motif 3; other site 364106008834 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 364106008835 DHHA1 domain; Region: DHHA1; pfam02272 364106008836 recombination regulator RecX; Reviewed; Region: recX; PRK00117 364106008837 recombinase A; Provisional; Region: recA; PRK09354 364106008838 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 364106008839 hexamer interface [polypeptide binding]; other site 364106008840 Walker A motif; other site 364106008841 ATP binding site [chemical binding]; other site 364106008842 Walker B motif; other site 364106008843 hypothetical protein; Validated; Region: PRK03661 364106008844 Transglycosylase SLT domain; Region: SLT_2; pfam13406 364106008845 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 364106008846 N-acetyl-D-glucosamine binding site [chemical binding]; other site 364106008847 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 364106008848 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 364106008849 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 364106008850 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 364106008851 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 364106008852 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 364106008853 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 364106008854 putative NAD(P) binding site [chemical binding]; other site 364106008855 active site 364106008856 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 364106008857 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 364106008858 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 364106008859 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 364106008860 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 364106008861 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 364106008862 putative active site [active] 364106008863 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 364106008864 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 364106008865 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 364106008866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106008867 Walker A motif; other site 364106008868 ATP binding site [chemical binding]; other site 364106008869 Walker B motif; other site 364106008870 arginine finger; other site 364106008871 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 364106008872 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 364106008873 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 364106008874 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 364106008875 iron binding site [ion binding]; other site 364106008876 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 364106008877 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 364106008878 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 364106008879 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 364106008880 Acylphosphatase; Region: Acylphosphatase; pfam00708 364106008881 HypF finger; Region: zf-HYPF; pfam07503 364106008882 HypF finger; Region: zf-HYPF; pfam07503 364106008883 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 364106008884 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 364106008885 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 364106008886 Transcriptional regulators [Transcription]; Region: PurR; COG1609 364106008887 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 364106008888 DNA binding site [nucleotide binding] 364106008889 domain linker motif; other site 364106008890 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 364106008891 dimerization interface (closed form) [polypeptide binding]; other site 364106008892 ligand binding site [chemical binding]; other site 364106008893 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 364106008894 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 364106008895 active site turn [active] 364106008896 phosphorylation site [posttranslational modification] 364106008897 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 364106008898 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 364106008899 beta-galactosidase; Region: BGL; TIGR03356 364106008900 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 364106008901 non-specific DNA binding site [nucleotide binding]; other site 364106008902 salt bridge; other site 364106008903 sequence-specific DNA binding site [nucleotide binding]; other site 364106008904 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 364106008905 nickel binding site [ion binding]; other site 364106008906 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 364106008907 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 364106008908 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 364106008909 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 364106008910 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 364106008911 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 364106008912 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 364106008913 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 364106008914 NADH dehydrogenase; Region: NADHdh; cl00469 364106008915 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 364106008916 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 364106008917 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 364106008918 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 364106008919 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 364106008920 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 364106008921 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 364106008922 hydrogenase assembly chaperone; Provisional; Region: PRK10409 364106008923 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 364106008924 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 364106008925 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 364106008926 dimerization interface [polypeptide binding]; other site 364106008927 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 364106008928 ATP binding site [chemical binding]; other site 364106008929 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 364106008930 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 364106008931 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 364106008932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106008933 Walker A motif; other site 364106008934 ATP binding site [chemical binding]; other site 364106008935 Walker B motif; other site 364106008936 arginine finger; other site 364106008937 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 364106008938 molybdenum-pterin binding domain; Region: Mop; TIGR00638 364106008939 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 364106008940 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 364106008941 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 364106008942 MutS domain I; Region: MutS_I; pfam01624 364106008943 MutS domain II; Region: MutS_II; pfam05188 364106008944 MutS domain III; Region: MutS_III; pfam05192 364106008945 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 364106008946 Walker A/P-loop; other site 364106008947 ATP binding site [chemical binding]; other site 364106008948 Q-loop/lid; other site 364106008949 ABC transporter signature motif; other site 364106008950 Walker B; other site 364106008951 D-loop; other site 364106008952 H-loop/switch region; other site 364106008953 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 364106008954 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 364106008955 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 364106008956 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 364106008957 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 364106008958 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 364106008959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 364106008960 putative aldolase; Validated; Region: PRK08130 364106008961 active site 364106008962 intersubunit interface [polypeptide binding]; other site 364106008963 Zn2+ binding site [ion binding]; other site 364106008964 hypothetical protein; Provisional; Region: PRK09989 364106008965 putative transporter; Provisional; Region: PRK09821 364106008966 GntP family permease; Region: GntP_permease; pfam02447 364106008967 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 364106008968 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 364106008969 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 364106008970 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 364106008971 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 364106008972 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 364106008973 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 364106008974 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 364106008975 DNA binding residues [nucleotide binding] 364106008976 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 364106008977 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 364106008978 Peptidase family M23; Region: Peptidase_M23; pfam01551 364106008979 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 364106008980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106008981 S-adenosylmethionine binding site [chemical binding]; other site 364106008982 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 364106008983 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 364106008984 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 364106008985 Permutation of conserved domain; other site 364106008986 active site 364106008987 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 364106008988 homotrimer interaction site [polypeptide binding]; other site 364106008989 zinc binding site [ion binding]; other site 364106008990 CDP-binding sites; other site 364106008991 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 364106008992 substrate binding site; other site 364106008993 dimer interface; other site 364106008994 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 364106008995 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 364106008996 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 364106008997 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 364106008998 ligand-binding site [chemical binding]; other site 364106008999 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 364106009000 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 364106009001 CysD dimerization site [polypeptide binding]; other site 364106009002 G1 box; other site 364106009003 putative GEF interaction site [polypeptide binding]; other site 364106009004 GTP/Mg2+ binding site [chemical binding]; other site 364106009005 Switch I region; other site 364106009006 G2 box; other site 364106009007 G3 box; other site 364106009008 Switch II region; other site 364106009009 G4 box; other site 364106009010 G5 box; other site 364106009011 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 364106009012 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 364106009013 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 364106009014 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 364106009015 Active Sites [active] 364106009016 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 364106009017 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 364106009018 metal binding site [ion binding]; metal-binding site 364106009019 Hok/gef family; Region: HOK_GEF; pfam01848 364106009020 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 364106009021 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 364106009022 Active Sites [active] 364106009023 sulfite reductase subunit beta; Provisional; Region: PRK13504 364106009024 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 364106009025 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 364106009026 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 364106009027 Flavodoxin; Region: Flavodoxin_1; pfam00258 364106009028 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 364106009029 FAD binding pocket [chemical binding]; other site 364106009030 FAD binding motif [chemical binding]; other site 364106009031 catalytic residues [active] 364106009032 NAD binding pocket [chemical binding]; other site 364106009033 phosphate binding motif [ion binding]; other site 364106009034 beta-alpha-beta structure motif; other site 364106009035 6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470 364106009036 homohexamer interface [polypeptide binding]; other site 364106009037 putative substrate stabilizing pore; other site 364106009038 pterin binding site; other site 364106009039 putative oxidoreductase FixC; Provisional; Region: PRK10157 364106009040 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 364106009041 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 364106009042 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 364106009043 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 364106009044 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 364106009045 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 364106009046 Ligand binding site [chemical binding]; other site 364106009047 Electron transfer flavoprotein domain; Region: ETF; pfam01012 364106009048 benzoate transport; Region: 2A0115; TIGR00895 364106009049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106009050 putative substrate translocation pore; other site 364106009051 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 364106009052 FAD binding domain; Region: FAD_binding_4; pfam01565 364106009053 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 364106009054 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 364106009055 NADP binding site [chemical binding]; other site 364106009056 homodimer interface [polypeptide binding]; other site 364106009057 active site 364106009058 Major Facilitator Superfamily; Region: MFS_1; pfam07690 364106009059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106009060 putative substrate translocation pore; other site 364106009061 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 364106009062 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 364106009063 nucleotide binding site [chemical binding]; other site 364106009064 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 364106009065 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 364106009066 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 364106009067 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 364106009068 Repair protein; Region: Repair_PSII; pfam04536 364106009069 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 364106009070 Repair protein; Region: Repair_PSII; pfam04536 364106009071 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 364106009072 Repair protein; Region: Repair_PSII; pfam04536 364106009073 enolase; Provisional; Region: eno; PRK00077 364106009074 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 364106009075 dimer interface [polypeptide binding]; other site 364106009076 metal binding site [ion binding]; metal-binding site 364106009077 substrate binding pocket [chemical binding]; other site 364106009078 CTP synthetase; Validated; Region: pyrG; PRK05380 364106009079 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 364106009080 Catalytic site [active] 364106009081 active site 364106009082 UTP binding site [chemical binding]; other site 364106009083 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 364106009084 active site 364106009085 putative oxyanion hole; other site 364106009086 catalytic triad [active] 364106009087 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 364106009088 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 364106009089 homodimer interface [polypeptide binding]; other site 364106009090 metal binding site [ion binding]; metal-binding site 364106009091 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 364106009092 homodimer interface [polypeptide binding]; other site 364106009093 active site 364106009094 putative chemical substrate binding site [chemical binding]; other site 364106009095 metal binding site [ion binding]; metal-binding site 364106009096 toxin MazF; Provisional; Region: PRK09907 364106009097 antitoxin MazE; Provisional; Region: PRK09798 364106009098 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 364106009099 HD domain; Region: HD_4; pfam13328 364106009100 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 364106009101 synthetase active site [active] 364106009102 NTP binding site [chemical binding]; other site 364106009103 metal binding site [ion binding]; metal-binding site 364106009104 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 364106009105 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 364106009106 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 364106009107 TRAM domain; Region: TRAM; pfam01938 364106009108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106009109 S-adenosylmethionine binding site [chemical binding]; other site 364106009110 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 364106009111 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 364106009112 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 364106009113 dimerization interface [polypeptide binding]; other site 364106009114 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 364106009115 dimer interface [polypeptide binding]; other site 364106009116 phosphorylation site [posttranslational modification] 364106009117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106009118 ATP binding site [chemical binding]; other site 364106009119 Mg2+ binding site [ion binding]; other site 364106009120 G-X-G motif; other site 364106009121 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 364106009122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106009123 active site 364106009124 phosphorylation site [posttranslational modification] 364106009125 intermolecular recognition site; other site 364106009126 dimerization interface [polypeptide binding]; other site 364106009127 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 364106009128 putative binding surface; other site 364106009129 active site 364106009130 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 364106009131 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 364106009132 active site 364106009133 tetramer interface [polypeptide binding]; other site 364106009134 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 364106009135 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 364106009136 active site 364106009137 tetramer interface [polypeptide binding]; other site 364106009138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106009139 D-galactonate transporter; Region: 2A0114; TIGR00893 364106009140 putative substrate translocation pore; other site 364106009141 flavodoxin; Provisional; Region: PRK08105 364106009142 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 364106009143 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 364106009144 probable active site [active] 364106009145 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 364106009146 SecY interacting protein Syd; Provisional; Region: PRK04968 364106009147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 364106009148 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 364106009149 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 364106009150 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 364106009151 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 364106009152 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 364106009153 serine transporter; Region: stp; TIGR00814 364106009154 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 364106009155 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 364106009156 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 364106009157 flap endonuclease-like protein; Provisional; Region: PRK09482 364106009158 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 364106009159 active site 364106009160 metal binding site 1 [ion binding]; metal-binding site 364106009161 putative 5' ssDNA interaction site; other site 364106009162 metal binding site 3; metal-binding site 364106009163 metal binding site 2 [ion binding]; metal-binding site 364106009164 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 364106009165 putative DNA binding site [nucleotide binding]; other site 364106009166 putative metal binding site [ion binding]; other site 364106009167 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 364106009168 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 364106009169 dimer interface [polypeptide binding]; other site 364106009170 active site 364106009171 metal binding site [ion binding]; metal-binding site 364106009172 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 364106009173 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 364106009174 intersubunit interface [polypeptide binding]; other site 364106009175 active site 364106009176 Zn2+ binding site [ion binding]; other site 364106009177 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 364106009178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106009179 putative substrate translocation pore; other site 364106009180 L-fucose isomerase; Provisional; Region: fucI; PRK10991 364106009181 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 364106009182 hexamer (dimer of trimers) interface [polypeptide binding]; other site 364106009183 trimer interface [polypeptide binding]; other site 364106009184 substrate binding site [chemical binding]; other site 364106009185 Mn binding site [ion binding]; other site 364106009186 L-fuculokinase; Provisional; Region: PRK10331 364106009187 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 364106009188 nucleotide binding site [chemical binding]; other site 364106009189 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 364106009190 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 364106009191 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 364106009192 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 364106009193 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 364106009194 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 364106009195 hypothetical protein; Provisional; Region: PRK10873 364106009196 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 364106009197 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106009198 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 364106009199 dimerization interface [polypeptide binding]; other site 364106009200 substrate binding pocket [chemical binding]; other site 364106009201 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 364106009202 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 364106009203 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 364106009204 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 364106009205 catalytic residue [active] 364106009206 CsdA-binding activator; Provisional; Region: PRK15019 364106009207 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 364106009208 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 364106009209 putative ATP binding site [chemical binding]; other site 364106009210 putative substrate interface [chemical binding]; other site 364106009211 murein transglycosylase A; Provisional; Region: mltA; PRK11162 364106009212 MltA specific insert domain; Region: MltA; pfam03562 364106009213 3D domain; Region: 3D; pfam06725 364106009214 Protein of unknown function (DUF770); Region: DUF770; pfam05591 364106009215 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 364106009216 Protein of unknown function (DUF877); Region: DUF877; pfam05943 364106009217 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 364106009218 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 364106009219 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 364106009220 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 364106009221 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 364106009222 ligand binding site [chemical binding]; other site 364106009223 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 364106009224 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 364106009225 Clp amino terminal domain; Region: Clp_N; pfam02861 364106009226 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106009227 Walker A motif; other site 364106009228 ATP binding site [chemical binding]; other site 364106009229 Walker B motif; other site 364106009230 arginine finger; other site 364106009231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106009232 Walker A motif; other site 364106009233 ATP binding site [chemical binding]; other site 364106009234 Walker B motif; other site 364106009235 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 364106009236 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 364106009237 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 364106009238 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 364106009239 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 364106009240 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 364106009241 PGAP1-like protein; Region: PGAP1; pfam07819 364106009242 PAAR motif; Region: PAAR_motif; pfam05488 364106009243 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 364106009244 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 364106009245 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 364106009246 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 364106009247 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 364106009248 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 364106009249 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 364106009250 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 364106009251 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 364106009252 ImpA domain protein; Region: DUF3702; pfam12486 364106009253 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 364106009254 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 364106009255 putative ligand binding site [chemical binding]; other site 364106009256 putative NAD binding site [chemical binding]; other site 364106009257 catalytic site [active] 364106009258 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 364106009259 putative active site [active] 364106009260 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 364106009261 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 364106009262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106009263 homodimer interface [polypeptide binding]; other site 364106009264 catalytic residue [active] 364106009265 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 364106009266 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 364106009267 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 364106009268 active site turn [active] 364106009269 phosphorylation site [posttranslational modification] 364106009270 CAT RNA binding domain; Region: CAT_RBD; pfam03123 364106009271 PRD domain; Region: PRD; pfam00874 364106009272 PRD domain; Region: PRD; pfam00874 364106009273 AMIN domain; Region: AMIN; pfam11741 364106009274 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 364106009275 active site 364106009276 metal binding site [ion binding]; metal-binding site 364106009277 N-acetylglutamate synthase; Validated; Region: PRK05279 364106009278 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 364106009279 putative feedback inhibition sensing region; other site 364106009280 putative nucleotide binding site [chemical binding]; other site 364106009281 putative substrate binding site [chemical binding]; other site 364106009282 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 364106009283 Coenzyme A binding pocket [chemical binding]; other site 364106009284 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 364106009285 AAA domain; Region: AAA_30; pfam13604 364106009286 Family description; Region: UvrD_C_2; pfam13538 364106009287 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 364106009288 protease3; Provisional; Region: PRK15101 364106009289 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 364106009290 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 364106009291 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 364106009292 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 364106009293 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 364106009294 hypothetical protein; Provisional; Region: PRK10332 364106009295 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 364106009296 hypothetical protein; Provisional; Region: PRK11521 364106009297 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 364106009298 hypothetical protein; Provisional; Region: PRK10557 364106009299 hypothetical protein; Provisional; Region: PRK10506 364106009300 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 364106009301 thymidylate synthase; Reviewed; Region: thyA; PRK01827 364106009302 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 364106009303 dimerization interface [polypeptide binding]; other site 364106009304 active site 364106009305 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 364106009306 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 364106009307 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 364106009308 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 364106009309 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 364106009310 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 364106009311 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 364106009312 putative active site [active] 364106009313 Ap4A binding site [chemical binding]; other site 364106009314 nudix motif; other site 364106009315 putative metal binding site [ion binding]; other site 364106009316 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 364106009317 putative DNA-binding cleft [nucleotide binding]; other site 364106009318 putative DNA clevage site; other site 364106009319 molecular lever; other site 364106009320 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 364106009321 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 364106009322 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 364106009323 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 364106009324 active site 364106009325 catalytic tetrad [active] 364106009326 lysophospholipid transporter LplT; Provisional; Region: PRK11195 364106009327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106009328 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 364106009329 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 364106009330 putative acyl-acceptor binding pocket; other site 364106009331 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 364106009332 acyl-activating enzyme (AAE) consensus motif; other site 364106009333 putative AMP binding site [chemical binding]; other site 364106009334 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 364106009335 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 364106009336 DNA binding site [nucleotide binding] 364106009337 domain linker motif; other site 364106009338 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 364106009339 dimerization interface (closed form) [polypeptide binding]; other site 364106009340 ligand binding site [chemical binding]; other site 364106009341 diaminopimelate decarboxylase; Provisional; Region: PRK11165 364106009342 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 364106009343 active site 364106009344 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 364106009345 substrate binding site [chemical binding]; other site 364106009346 catalytic residues [active] 364106009347 dimer interface [polypeptide binding]; other site 364106009348 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 364106009349 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106009350 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 364106009351 dimerization interface [polypeptide binding]; other site 364106009352 putative racemase; Provisional; Region: PRK10200 364106009353 aspartate racemase; Region: asp_race; TIGR00035 364106009354 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 364106009355 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 364106009356 NADP binding site [chemical binding]; other site 364106009357 homodimer interface [polypeptide binding]; other site 364106009358 active site 364106009359 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 364106009360 putative acyltransferase; Provisional; Region: PRK05790 364106009361 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 364106009362 dimer interface [polypeptide binding]; other site 364106009363 active site 364106009364 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 364106009365 serine transporter; Region: stp; TIGR00814 364106009366 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 364106009367 Peptidase family M23; Region: Peptidase_M23; pfam01551 364106009368 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 364106009369 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 364106009370 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 364106009371 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 364106009372 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 364106009373 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 364106009374 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 364106009375 catalytic loop [active] 364106009376 iron binding site [ion binding]; other site 364106009377 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 364106009378 GAF domain; Region: GAF; cl17456 364106009379 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 364106009380 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 364106009381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106009382 Walker A motif; other site 364106009383 ATP binding site [chemical binding]; other site 364106009384 Walker B motif; other site 364106009385 arginine finger; other site 364106009386 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 364106009387 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 364106009388 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 364106009389 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 364106009390 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 364106009391 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 364106009392 catalytic residue [active] 364106009393 peptidase; Reviewed; Region: PRK13004 364106009394 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 364106009395 putative metal binding site [ion binding]; other site 364106009396 putative dimer interface [polypeptide binding]; other site 364106009397 D-hydantoinase; Region: D-hydantoinase; TIGR02033 364106009398 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 364106009399 tetramer interface [polypeptide binding]; other site 364106009400 active site 364106009401 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 364106009402 carbamate kinase; Reviewed; Region: PRK12686 364106009403 putative substrate binding site [chemical binding]; other site 364106009404 homodimer interface [polypeptide binding]; other site 364106009405 nucleotide binding site [chemical binding]; other site 364106009406 nucleotide binding site [chemical binding]; other site 364106009407 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 364106009408 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 364106009409 XdhC Rossmann domain; Region: XdhC_C; pfam13478 364106009410 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 364106009411 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 364106009412 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 364106009413 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 364106009414 Ligand binding site; other site 364106009415 metal-binding site 364106009416 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 364106009417 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 364106009418 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 364106009419 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 364106009420 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 364106009421 active site 364106009422 putative substrate binding pocket [chemical binding]; other site 364106009423 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 364106009424 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 364106009425 putative hypoxanthine oxidase; Provisional; Region: PRK09800 364106009426 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 364106009427 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 364106009428 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 364106009429 uracil-xanthine permease; Region: ncs2; TIGR00801 364106009430 guanine deaminase; Provisional; Region: PRK09228 364106009431 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 364106009432 active site 364106009433 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 364106009434 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 364106009435 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 364106009436 4Fe-4S binding domain; Region: Fer4; pfam00037 364106009437 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 364106009438 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 364106009439 xanthine permease; Region: pbuX; TIGR03173 364106009440 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 364106009441 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 364106009442 active site 364106009443 metal binding site [ion binding]; metal-binding site 364106009444 nudix motif; other site 364106009445 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 364106009446 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 364106009447 dimer interface [polypeptide binding]; other site 364106009448 putative anticodon binding site; other site 364106009449 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 364106009450 motif 1; other site 364106009451 active site 364106009452 motif 2; other site 364106009453 motif 3; other site 364106009454 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 364106009455 DHH family; Region: DHH; pfam01368 364106009456 DHHA1 domain; Region: DHHA1; pfam02272 364106009457 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 364106009458 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 364106009459 dimerization domain [polypeptide binding]; other site 364106009460 dimer interface [polypeptide binding]; other site 364106009461 catalytic residues [active] 364106009462 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 364106009463 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 364106009464 active site 364106009465 Int/Topo IB signature motif; other site 364106009466 flavodoxin FldB; Provisional; Region: PRK12359 364106009467 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 364106009468 hypothetical protein; Provisional; Region: PRK10878 364106009469 putative global regulator; Reviewed; Region: PRK09559 364106009470 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 364106009471 hemolysin; Provisional; Region: PRK15087 364106009472 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 364106009473 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 364106009474 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 364106009475 beta-galactosidase; Region: BGL; TIGR03356 364106009476 glycine dehydrogenase; Provisional; Region: PRK05367 364106009477 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 364106009478 tetramer interface [polypeptide binding]; other site 364106009479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106009480 catalytic residue [active] 364106009481 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 364106009482 tetramer interface [polypeptide binding]; other site 364106009483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106009484 catalytic residue [active] 364106009485 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 364106009486 lipoyl attachment site [posttranslational modification]; other site 364106009487 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 364106009488 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 364106009489 oxidoreductase; Provisional; Region: PRK08013 364106009490 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 364106009491 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 364106009492 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 364106009493 proline aminopeptidase P II; Provisional; Region: PRK10879 364106009494 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 364106009495 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 364106009496 active site 364106009497 hypothetical protein; Reviewed; Region: PRK01736 364106009498 Z-ring-associated protein; Provisional; Region: PRK10972 364106009499 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 364106009500 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 364106009501 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 364106009502 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 364106009503 ligand binding site [chemical binding]; other site 364106009504 NAD binding site [chemical binding]; other site 364106009505 tetramer interface [polypeptide binding]; other site 364106009506 catalytic site [active] 364106009507 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 364106009508 L-serine binding site [chemical binding]; other site 364106009509 ACT domain interface; other site 364106009510 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 364106009511 tetramer (dimer of dimers) interface [polypeptide binding]; other site 364106009512 active site 364106009513 dimer interface [polypeptide binding]; other site 364106009514 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 364106009515 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 364106009516 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106009517 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 364106009518 putative dimerization interface [polypeptide binding]; other site 364106009519 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 364106009520 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106009521 Transcriptional regulator [Transcription]; Region: LysR; COG0583 364106009522 Uncharacterized conserved protein [Function unknown]; Region: COG2968 364106009523 oxidative stress defense protein; Provisional; Region: PRK11087 364106009524 arginine exporter protein; Provisional; Region: PRK09304 364106009525 mechanosensitive channel MscS; Provisional; Region: PRK10334 364106009526 Mechanosensitive ion channel; Region: MS_channel; pfam00924 364106009527 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 364106009528 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 364106009529 active site 364106009530 intersubunit interface [polypeptide binding]; other site 364106009531 zinc binding site [ion binding]; other site 364106009532 Na+ binding site [ion binding]; other site 364106009533 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 364106009534 Phosphoglycerate kinase; Region: PGK; pfam00162 364106009535 substrate binding site [chemical binding]; other site 364106009536 hinge regions; other site 364106009537 ADP binding site [chemical binding]; other site 364106009538 catalytic site [active] 364106009539 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 364106009540 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 364106009541 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 364106009542 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 364106009543 trimer interface [polypeptide binding]; other site 364106009544 putative Zn binding site [ion binding]; other site 364106009545 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 364106009546 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 364106009547 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 364106009548 Q-loop/lid; other site 364106009549 ABC transporter signature motif; other site 364106009550 Walker B; other site 364106009551 D-loop; other site 364106009552 H-loop/switch region; other site 364106009553 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 364106009554 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 364106009555 Walker A/P-loop; other site 364106009556 ATP binding site [chemical binding]; other site 364106009557 Q-loop/lid; other site 364106009558 ABC transporter signature motif; other site 364106009559 Walker B; other site 364106009560 D-loop; other site 364106009561 H-loop/switch region; other site 364106009562 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 364106009563 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 364106009564 active site 364106009565 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 364106009566 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 364106009567 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 364106009568 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 364106009569 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 364106009570 putative NAD(P) binding site [chemical binding]; other site 364106009571 catalytic Zn binding site [ion binding]; other site 364106009572 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 364106009573 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 364106009574 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 364106009575 active site 364106009576 P-loop; other site 364106009577 phosphorylation site [posttranslational modification] 364106009578 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 364106009579 active site 364106009580 phosphorylation site [posttranslational modification] 364106009581 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 364106009582 SPFH domain / Band 7 family; Region: Band_7; pfam01145 364106009583 transketolase; Reviewed; Region: PRK12753 364106009584 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 364106009585 TPP-binding site [chemical binding]; other site 364106009586 dimer interface [polypeptide binding]; other site 364106009587 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 364106009588 PYR/PP interface [polypeptide binding]; other site 364106009589 dimer interface [polypeptide binding]; other site 364106009590 TPP binding site [chemical binding]; other site 364106009591 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 364106009592 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 364106009593 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 364106009594 agmatinase; Region: agmatinase; TIGR01230 364106009595 oligomer interface [polypeptide binding]; other site 364106009596 putative active site [active] 364106009597 Mn binding site [ion binding]; other site 364106009598 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 364106009599 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 364106009600 dimer interface [polypeptide binding]; other site 364106009601 active site 364106009602 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 364106009603 catalytic residues [active] 364106009604 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 364106009605 Virulence promoting factor; Region: YqgB; pfam11036 364106009606 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 364106009607 S-adenosylmethionine synthetase; Validated; Region: PRK05250 364106009608 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 364106009609 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 364106009610 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 364106009611 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 364106009612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106009613 putative substrate translocation pore; other site 364106009614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106009615 hypothetical protein; Provisional; Region: PRK04860 364106009616 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 364106009617 DNA-specific endonuclease I; Provisional; Region: PRK15137 364106009618 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 364106009619 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 364106009620 RNA methyltransferase, RsmE family; Region: TIGR00046 364106009621 glutathione synthetase; Provisional; Region: PRK05246 364106009622 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 364106009623 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 364106009624 hypothetical protein; Validated; Region: PRK00228 364106009625 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 364106009626 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 364106009627 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 364106009628 Walker A motif; other site 364106009629 ATP binding site [chemical binding]; other site 364106009630 Walker B motif; other site 364106009631 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 364106009632 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 364106009633 catalytic residue [active] 364106009634 YGGT family; Region: YGGT; pfam02325 364106009635 YGGT family; Region: YGGT; pfam02325 364106009636 hypothetical protein; Validated; Region: PRK05090 364106009637 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 364106009638 active site 364106009639 dimerization interface [polypeptide binding]; other site 364106009640 HemN family oxidoreductase; Provisional; Region: PRK05660 364106009641 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 364106009642 FeS/SAM binding site; other site 364106009643 HemN C-terminal domain; Region: HemN_C; pfam06969 364106009644 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 364106009645 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 364106009646 homodimer interface [polypeptide binding]; other site 364106009647 active site 364106009648 hypothetical protein; Provisional; Region: PRK10626 364106009649 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 364106009650 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 364106009651 hypothetical protein; Provisional; Region: PRK11702 364106009652 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 364106009653 adenine DNA glycosylase; Provisional; Region: PRK10880 364106009654 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 364106009655 minor groove reading motif; other site 364106009656 helix-hairpin-helix signature motif; other site 364106009657 substrate binding pocket [chemical binding]; other site 364106009658 active site 364106009659 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 364106009660 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 364106009661 DNA binding and oxoG recognition site [nucleotide binding] 364106009662 oxidative damage protection protein; Provisional; Region: PRK05408 364106009663 murein transglycosylase C; Provisional; Region: mltC; PRK11671 364106009664 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 364106009665 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 364106009666 N-acetyl-D-glucosamine binding site [chemical binding]; other site 364106009667 catalytic residue [active] 364106009668 nucleoside transporter; Region: 2A0110; TIGR00889 364106009669 ornithine decarboxylase; Provisional; Region: PRK13578 364106009670 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 364106009671 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 364106009672 homodimer interface [polypeptide binding]; other site 364106009673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106009674 catalytic residue [active] 364106009675 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 364106009676 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 364106009677 KpsF/GutQ family protein; Region: kpsF; TIGR00393 364106009678 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 364106009679 putative active site [active] 364106009680 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 364106009681 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 364106009682 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 364106009683 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 364106009684 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 364106009685 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 364106009686 Ligand binding site; other site 364106009687 oligomer interface; other site 364106009688 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 364106009689 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 364106009690 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 364106009691 Alpha-2,8-polysialyltransferase (POLYST); Region: A-2_8-polyST; pfam07388 364106009692 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 364106009693 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 364106009694 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 364106009695 active site 364106009696 homodimer interface [polypeptide binding]; other site 364106009697 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 364106009698 ligand binding site; other site 364106009699 tetramer interface; other site 364106009700 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 364106009701 active site 364106009702 catalytic triad [active] 364106009703 oxyanion hole [active] 364106009704 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 364106009705 NeuB family; Region: NeuB; pfam03102 364106009706 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 364106009707 NeuB binding interface [polypeptide binding]; other site 364106009708 putative substrate binding site [chemical binding]; other site 364106009709 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 364106009710 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 364106009711 putative trimer interface [polypeptide binding]; other site 364106009712 putative CoA binding site [chemical binding]; other site 364106009713 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 364106009714 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 364106009715 Walker A/P-loop; other site 364106009716 ATP binding site [chemical binding]; other site 364106009717 Q-loop/lid; other site 364106009718 ABC transporter signature motif; other site 364106009719 Walker B; other site 364106009720 D-loop; other site 364106009721 H-loop/switch region; other site 364106009722 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 364106009723 putative general secretion pathway protein YghD; Provisional; Region: PRK09731 364106009724 GspL-like protein; Provisional; Region: PRK09662 364106009725 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 364106009726 type II secretion system protein J; Region: gspJ; TIGR01711 364106009727 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 364106009728 type II secretion system protein I; Region: gspI; TIGR01707 364106009729 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 364106009730 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 364106009731 Type II transport protein GspH; Region: GspH; pfam12019 364106009732 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 364106009733 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 364106009734 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 364106009735 type II secretion system protein F; Region: GspF; TIGR02120 364106009736 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 364106009737 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 364106009738 type II secretion system protein E; Region: type_II_gspE; TIGR02533 364106009739 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 364106009740 Walker A motif; other site 364106009741 ATP binding site [chemical binding]; other site 364106009742 Walker B motif; other site 364106009743 type II secretion system protein D; Region: type_II_gspD; TIGR02517 364106009744 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 364106009745 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 364106009746 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 364106009747 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 364106009748 putative type II secretion protein GspC; Provisional; Region: PRK09681 364106009749 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 364106009750 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 364106009751 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 364106009752 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 364106009753 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 364106009754 Domain of unknown function (DUF4092); Region: DUF4092; pfam13322 364106009755 Peptidase M60-like family; Region: M60-like; pfam13402 364106009756 glycolate transporter; Provisional; Region: PRK09695 364106009757 L-lactate permease; Region: Lactate_perm; cl00701 364106009758 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 364106009759 active site 364106009760 hypothetical protein; Provisional; Region: PRK09732 364106009761 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 364106009762 FAD binding domain; Region: FAD_binding_4; pfam01565 364106009763 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 364106009764 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 364106009765 DNA-binding site [nucleotide binding]; DNA binding site 364106009766 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 364106009767 acyl-CoA synthetase; Validated; Region: PRK09192 364106009768 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 364106009769 acyl-activating enzyme (AAE) consensus motif; other site 364106009770 active site 364106009771 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 364106009772 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 364106009773 NAD(P) binding site [chemical binding]; other site 364106009774 active site 364106009775 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 364106009776 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 364106009777 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 364106009778 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 364106009779 catalytic residue [active] 364106009780 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 364106009781 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 364106009782 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 364106009783 Predicted permeases [General function prediction only]; Region: COG0795 364106009784 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 364106009785 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 364106009786 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 364106009787 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 364106009788 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 364106009789 active site 364106009790 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 364106009791 TMP-binding site; other site 364106009792 ATP-binding site [chemical binding]; other site 364106009793 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 364106009794 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 364106009795 TMP-binding site; other site 364106009796 ATP-binding site [chemical binding]; other site 364106009797 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 364106009798 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 364106009799 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 364106009800 CHAP domain; Region: CHAP; pfam05257 364106009801 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 364106009802 putative S-transferase; Provisional; Region: PRK11752 364106009803 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 364106009804 C-terminal domain interface [polypeptide binding]; other site 364106009805 GSH binding site (G-site) [chemical binding]; other site 364106009806 dimer interface [polypeptide binding]; other site 364106009807 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 364106009808 dimer interface [polypeptide binding]; other site 364106009809 N-terminal domain interface [polypeptide binding]; other site 364106009810 active site 364106009811 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 364106009812 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 364106009813 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 364106009814 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 364106009815 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 364106009816 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 364106009817 putative substrate-binding site; other site 364106009818 nickel binding site [ion binding]; other site 364106009819 hydrogenase 2 large subunit; Provisional; Region: PRK10467 364106009820 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 364106009821 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 364106009822 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 364106009823 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 364106009824 4Fe-4S binding domain; Region: Fer4_6; pfam12837 364106009825 hydrogenase 2 small subunit; Provisional; Region: PRK10468 364106009826 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 364106009827 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 364106009828 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 364106009829 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 364106009830 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 364106009831 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 364106009832 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 364106009833 active site 364106009834 catalytic tetrad [active] 364106009835 hypothetical protein; Provisional; Region: PRK05208 364106009836 oxidoreductase; Provisional; Region: PRK07985 364106009837 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 364106009838 NAD binding site [chemical binding]; other site 364106009839 metal binding site [ion binding]; metal-binding site 364106009840 active site 364106009841 biopolymer transport protein ExbD; Provisional; Region: PRK11267 364106009842 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 364106009843 biopolymer transport protein ExbB; Provisional; Region: PRK10414 364106009844 cystathionine beta-lyase; Provisional; Region: PRK08114 364106009845 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 364106009846 homodimer interface [polypeptide binding]; other site 364106009847 substrate-cofactor binding pocket; other site 364106009848 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106009849 catalytic residue [active] 364106009850 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 364106009851 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 364106009852 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 364106009853 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 364106009854 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106009855 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106009856 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 364106009857 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 364106009858 dimer interface [polypeptide binding]; other site 364106009859 active site 364106009860 metal binding site [ion binding]; metal-binding site 364106009861 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 364106009862 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 364106009863 active site 364106009864 catalytic tetrad [active] 364106009865 putative outer membrane lipoprotein; Provisional; Region: PRK09973 364106009866 hypothetical protein; Provisional; Region: PRK01254 364106009867 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 364106009868 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 364106009869 Transcriptional regulators [Transcription]; Region: FadR; COG2186 364106009870 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 364106009871 DNA-binding site [nucleotide binding]; DNA binding site 364106009872 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 364106009873 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 364106009874 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 364106009875 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 364106009876 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 364106009877 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 364106009878 putative NAD(P) binding site [chemical binding]; other site 364106009879 catalytic Zn binding site [ion binding]; other site 364106009880 structural Zn binding site [ion binding]; other site 364106009881 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 364106009882 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 364106009883 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 364106009884 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 364106009885 DctM-like transporters; Region: DctM; pfam06808 364106009886 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 364106009887 FtsI repressor; Provisional; Region: PRK10883 364106009888 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 364106009889 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 364106009890 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 364106009891 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 364106009892 putative acyl-acceptor binding pocket; other site 364106009893 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 364106009894 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 364106009895 CAP-like domain; other site 364106009896 active site 364106009897 primary dimer interface [polypeptide binding]; other site 364106009898 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 364106009899 putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755 364106009900 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 364106009901 peptide binding site [polypeptide binding]; other site 364106009902 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 364106009903 TIGR00156 family protein; Region: TIGR00156 364106009904 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 364106009905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106009906 active site 364106009907 phosphorylation site [posttranslational modification] 364106009908 intermolecular recognition site; other site 364106009909 dimerization interface [polypeptide binding]; other site 364106009910 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 364106009911 DNA binding site [nucleotide binding] 364106009912 sensor protein QseC; Provisional; Region: PRK10337 364106009913 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 364106009914 dimer interface [polypeptide binding]; other site 364106009915 phosphorylation site [posttranslational modification] 364106009916 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106009917 ATP binding site [chemical binding]; other site 364106009918 Mg2+ binding site [ion binding]; other site 364106009919 G-X-G motif; other site 364106009920 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 364106009921 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 364106009922 Uncharacterized conserved protein [Function unknown]; Region: COG1359 364106009923 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 364106009924 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 364106009925 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cd04795 364106009926 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 364106009927 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 364106009928 siderophore binding site; other site 364106009929 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 364106009930 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 364106009931 ABC-ATPase subunit interface; other site 364106009932 dimer interface [polypeptide binding]; other site 364106009933 putative PBP binding regions; other site 364106009934 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 364106009935 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 364106009936 dimer interface [polypeptide binding]; other site 364106009937 putative PBP binding regions; other site 364106009938 ABC-ATPase subunit interface; other site 364106009939 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 364106009940 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 364106009941 Walker A/P-loop; other site 364106009942 ATP binding site [chemical binding]; other site 364106009943 Q-loop/lid; other site 364106009944 ABC transporter signature motif; other site 364106009945 Walker B; other site 364106009946 D-loop; other site 364106009947 H-loop/switch region; other site 364106009948 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 364106009949 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 364106009950 N-terminal plug; other site 364106009951 ligand-binding site [chemical binding]; other site 364106009952 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 364106009953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106009954 ATP binding site [chemical binding]; other site 364106009955 Mg2+ binding site [ion binding]; other site 364106009956 G-X-G motif; other site 364106009957 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 364106009958 anchoring element; other site 364106009959 dimer interface [polypeptide binding]; other site 364106009960 ATP binding site [chemical binding]; other site 364106009961 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 364106009962 active site 364106009963 metal binding site [ion binding]; metal-binding site 364106009964 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 364106009965 esterase YqiA; Provisional; Region: PRK11071 364106009966 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 364106009967 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 364106009968 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 364106009969 active site 364106009970 metal binding site [ion binding]; metal-binding site 364106009971 hexamer interface [polypeptide binding]; other site 364106009972 putative dehydrogenase; Provisional; Region: PRK11039 364106009973 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 364106009974 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 364106009975 dimer interface [polypeptide binding]; other site 364106009976 ADP-ribose binding site [chemical binding]; other site 364106009977 active site 364106009978 nudix motif; other site 364106009979 metal binding site [ion binding]; metal-binding site 364106009980 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 364106009981 hypothetical protein; Provisional; Region: PRK11653 364106009982 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 364106009983 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 364106009984 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 364106009985 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 364106009986 catalytic residues [active] 364106009987 hinge region; other site 364106009988 alpha helical domain; other site 364106009989 putative disulfide oxidoreductase; Provisional; Region: PRK04307 364106009990 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 364106009991 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 364106009992 putative active site [active] 364106009993 metal binding site [ion binding]; metal-binding site 364106009994 zinc transporter ZupT; Provisional; Region: PRK04201 364106009995 ZIP Zinc transporter; Region: Zip; pfam02535 364106009996 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 364106009997 putative fimbrial protein; Provisional; Region: PRK09733 364106009998 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 364106009999 PapC N-terminal domain; Region: PapC_N; pfam13954 364106010000 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 364106010001 PapC C-terminal domain; Region: PapC_C; pfam13953 364106010002 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 364106010003 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 364106010004 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 364106010005 Fimbrial protein; Region: Fimbrial; pfam00419 364106010006 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 364106010007 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 364106010008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 364106010009 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 364106010010 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 364106010011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 364106010012 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 364106010013 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 364106010014 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 364106010015 putative ribose interaction site [chemical binding]; other site 364106010016 putative ADP binding site [chemical binding]; other site 364106010017 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 364106010018 active site 364106010019 nucleotide binding site [chemical binding]; other site 364106010020 HIGH motif; other site 364106010021 KMSKS motif; other site 364106010022 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 364106010023 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 364106010024 metal binding triad; other site 364106010025 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 364106010026 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 364106010027 metal binding triad; other site 364106010028 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 364106010029 Uncharacterized conserved protein [Function unknown]; Region: COG3025 364106010030 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 364106010031 putative active site [active] 364106010032 putative metal binding residues [ion binding]; other site 364106010033 signature motif; other site 364106010034 putative triphosphate binding site [ion binding]; other site 364106010035 CHAD domain; Region: CHAD; pfam05235 364106010036 SH3 domain-containing protein; Provisional; Region: PRK10884 364106010037 Bacterial SH3 domain homologues; Region: SH3b; smart00287 364106010038 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 364106010039 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 364106010040 active site 364106010041 NTP binding site [chemical binding]; other site 364106010042 metal binding triad [ion binding]; metal-binding site 364106010043 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 364106010044 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 364106010045 Zn2+ binding site [ion binding]; other site 364106010046 Mg2+ binding site [ion binding]; other site 364106010047 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 364106010048 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 364106010049 homooctamer interface [polypeptide binding]; other site 364106010050 active site 364106010051 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 364106010052 transcriptional activator TtdR; Provisional; Region: PRK09801 364106010053 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106010054 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 364106010055 putative effector binding pocket; other site 364106010056 putative dimerization interface [polypeptide binding]; other site 364106010057 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 364106010058 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 364106010059 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 364106010060 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 364106010061 transmembrane helices; other site 364106010062 UGMP family protein; Validated; Region: PRK09604 364106010063 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 364106010064 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 364106010065 DNA primase; Validated; Region: dnaG; PRK05667 364106010066 CHC2 zinc finger; Region: zf-CHC2; pfam01807 364106010067 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 364106010068 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 364106010069 active site 364106010070 metal binding site [ion binding]; metal-binding site 364106010071 interdomain interaction site; other site 364106010072 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 364106010073 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 364106010074 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 364106010075 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 364106010076 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 364106010077 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 364106010078 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 364106010079 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 364106010080 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 364106010081 DNA binding residues [nucleotide binding] 364106010082 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 364106010083 active site 364106010084 SUMO-1 interface [polypeptide binding]; other site 364106010085 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 364106010086 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 364106010087 FAD binding pocket [chemical binding]; other site 364106010088 FAD binding motif [chemical binding]; other site 364106010089 phosphate binding motif [ion binding]; other site 364106010090 NAD binding pocket [chemical binding]; other site 364106010091 Predicted transcriptional regulators [Transcription]; Region: COG1695 364106010092 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 364106010093 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 364106010094 PAS fold; Region: PAS_3; pfam08447 364106010095 putative active site [active] 364106010096 heme pocket [chemical binding]; other site 364106010097 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 364106010098 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 364106010099 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 364106010100 dimer interface [polypeptide binding]; other site 364106010101 putative CheW interface [polypeptide binding]; other site 364106010102 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 364106010103 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 364106010104 inhibitor-cofactor binding pocket; inhibition site 364106010105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106010106 catalytic residue [active] 364106010107 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 364106010108 dimer interface [polypeptide binding]; other site 364106010109 putative tRNA-binding site [nucleotide binding]; other site 364106010110 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 364106010111 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 364106010112 DNA binding site [nucleotide binding] 364106010113 domain linker motif; other site 364106010114 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 364106010115 putative dimerization interface [polypeptide binding]; other site 364106010116 putative ligand binding site [chemical binding]; other site 364106010117 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 364106010118 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 364106010119 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 364106010120 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 364106010121 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 364106010122 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 364106010123 inner membrane transporter YjeM; Provisional; Region: PRK15238 364106010124 alpha-glucosidase; Provisional; Region: PRK10137 364106010125 Protein of unknown function, DUF608; Region: DUF608; pfam04685 364106010126 Trehalase; Region: Trehalase; cl17346 364106010127 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 364106010128 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 364106010129 active site 364106010130 FMN binding site [chemical binding]; other site 364106010131 2,4-decadienoyl-CoA binding site; other site 364106010132 catalytic residue [active] 364106010133 4Fe-4S cluster binding site [ion binding]; other site 364106010134 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 364106010135 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 364106010136 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106010137 S-adenosylmethionine binding site [chemical binding]; other site 364106010138 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 364106010139 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 364106010140 putative active site [active] 364106010141 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 364106010142 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 364106010143 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 364106010144 serine/threonine transporter SstT; Provisional; Region: PRK13628 364106010145 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 364106010146 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 364106010147 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 364106010148 galactarate dehydratase; Region: galactar-dH20; TIGR03248 364106010149 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 364106010150 Glucuronate isomerase; Region: UxaC; pfam02614 364106010151 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 364106010152 D-galactonate transporter; Region: 2A0114; TIGR00893 364106010153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106010154 putative substrate translocation pore; other site 364106010155 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 364106010156 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 364106010157 DNA-binding site [nucleotide binding]; DNA binding site 364106010158 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 364106010159 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 364106010160 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 364106010161 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 364106010162 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 364106010163 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 364106010164 Predicted membrane protein [Function unknown]; Region: COG5393 364106010165 YqjK-like protein; Region: YqjK; pfam13997 364106010166 Predicted membrane protein [Function unknown]; Region: COG2259 364106010167 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 364106010168 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 364106010169 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 364106010170 putative dimer interface [polypeptide binding]; other site 364106010171 N-terminal domain interface [polypeptide binding]; other site 364106010172 putative substrate binding pocket (H-site) [chemical binding]; other site 364106010173 Predicted membrane protein [Function unknown]; Region: COG3152 364106010174 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106010175 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 364106010176 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 364106010177 dimerization interface [polypeptide binding]; other site 364106010178 Pirin-related protein [General function prediction only]; Region: COG1741 364106010179 Pirin; Region: Pirin; pfam02678 364106010180 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 364106010181 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 364106010182 serine transporter; Region: stp; TIGR00814 364106010183 L-serine dehydratase TdcG; Provisional; Region: PRK15040 364106010184 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 364106010185 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 364106010186 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 364106010187 homotrimer interaction site [polypeptide binding]; other site 364106010188 putative active site [active] 364106010189 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 364106010190 Pyruvate formate lyase 1; Region: PFL1; cd01678 364106010191 coenzyme A binding site [chemical binding]; other site 364106010192 active site 364106010193 catalytic residues [active] 364106010194 glycine loop; other site 364106010195 propionate/acetate kinase; Provisional; Region: PRK12379 364106010196 Acetokinase family; Region: Acetate_kinase; cl17229 364106010197 threonine/serine transporter TdcC; Provisional; Region: PRK13629 364106010198 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 364106010199 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 364106010200 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 364106010201 tetramer interface [polypeptide binding]; other site 364106010202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106010203 catalytic residue [active] 364106010204 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 364106010205 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106010206 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 364106010207 putative substrate binding pocket [chemical binding]; other site 364106010208 putative dimerization interface [polypeptide binding]; other site 364106010209 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 364106010210 glycerate kinase I; Provisional; Region: PRK10342 364106010211 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 364106010212 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 364106010213 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 364106010214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106010215 D-galactonate transporter; Region: 2A0114; TIGR00893 364106010216 putative substrate translocation pore; other site 364106010217 galactarate dehydratase; Region: galactar-dH20; TIGR03248 364106010218 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 364106010219 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 364106010220 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 364106010221 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 364106010222 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 364106010223 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 364106010224 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 364106010225 active site 364106010226 phosphorylation site [posttranslational modification] 364106010227 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 364106010228 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 364106010229 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 364106010230 active pocket/dimerization site; other site 364106010231 active site 364106010232 phosphorylation site [posttranslational modification] 364106010233 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 364106010234 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 364106010235 active site 364106010236 dimer interface [polypeptide binding]; other site 364106010237 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 364106010238 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 364106010239 dimer interface [polypeptide binding]; other site 364106010240 active site 364106010241 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 364106010242 putative active site [active] 364106010243 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453 364106010244 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 364106010245 active site 364106010246 intersubunit interface [polypeptide binding]; other site 364106010247 zinc binding site [ion binding]; other site 364106010248 Na+ binding site [ion binding]; other site 364106010249 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 364106010250 active site 364106010251 phosphorylation site [posttranslational modification] 364106010252 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 364106010253 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 364106010254 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 364106010255 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 364106010256 active site 364106010257 trimer interface [polypeptide binding]; other site 364106010258 allosteric site; other site 364106010259 active site lid [active] 364106010260 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 364106010261 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 364106010262 putative SAM binding site [chemical binding]; other site 364106010263 putative homodimer interface [polypeptide binding]; other site 364106010264 TIGR00252 family protein; Region: TIGR00252 364106010265 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 364106010266 dimer interface [polypeptide binding]; other site 364106010267 active site 364106010268 outer membrane lipoprotein; Provisional; Region: PRK11023 364106010269 BON domain; Region: BON; pfam04972 364106010270 BON domain; Region: BON; pfam04972 364106010271 Predicted permease; Region: DUF318; pfam03773 364106010272 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 364106010273 NADH(P)-binding; Region: NAD_binding_10; pfam13460 364106010274 NAD binding site [chemical binding]; other site 364106010275 active site 364106010276 intracellular protease, PfpI family; Region: PfpI; TIGR01382 364106010277 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 364106010278 proposed catalytic triad [active] 364106010279 conserved cys residue [active] 364106010280 hypothetical protein; Provisional; Region: PRK03467 364106010281 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 364106010282 GIY-YIG motif/motif A; other site 364106010283 putative active site [active] 364106010284 putative metal binding site [ion binding]; other site 364106010285 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 364106010286 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 364106010287 Coenzyme A binding pocket [chemical binding]; other site 364106010288 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 364106010289 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 364106010290 Peptidase family U32; Region: Peptidase_U32; pfam01136 364106010291 putative protease; Provisional; Region: PRK15447 364106010292 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 364106010293 hypothetical protein; Provisional; Region: PRK10508 364106010294 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 364106010295 tryptophan permease; Provisional; Region: PRK10483 364106010296 aromatic amino acid transport protein; Region: araaP; TIGR00837 364106010297 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 364106010298 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 364106010299 ATP binding site [chemical binding]; other site 364106010300 Mg++ binding site [ion binding]; other site 364106010301 motif III; other site 364106010302 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 364106010303 nucleotide binding region [chemical binding]; other site 364106010304 ATP-binding site [chemical binding]; other site 364106010305 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 364106010306 putative RNA binding site [nucleotide binding]; other site 364106010307 lipoprotein NlpI; Provisional; Region: PRK11189 364106010308 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 364106010309 binding surface 364106010310 TPR motif; other site 364106010311 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 364106010312 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 364106010313 RNase E interface [polypeptide binding]; other site 364106010314 trimer interface [polypeptide binding]; other site 364106010315 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 364106010316 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 364106010317 RNase E interface [polypeptide binding]; other site 364106010318 trimer interface [polypeptide binding]; other site 364106010319 active site 364106010320 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 364106010321 putative nucleic acid binding region [nucleotide binding]; other site 364106010322 G-X-X-G motif; other site 364106010323 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 364106010324 RNA binding site [nucleotide binding]; other site 364106010325 domain interface; other site 364106010326 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 364106010327 16S/18S rRNA binding site [nucleotide binding]; other site 364106010328 S13e-L30e interaction site [polypeptide binding]; other site 364106010329 25S rRNA binding site [nucleotide binding]; other site 364106010330 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 364106010331 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 364106010332 RNA binding site [nucleotide binding]; other site 364106010333 active site 364106010334 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 364106010335 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 364106010336 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 364106010337 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 364106010338 translation initiation factor IF-2; Region: IF-2; TIGR00487 364106010339 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 364106010340 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 364106010341 G1 box; other site 364106010342 putative GEF interaction site [polypeptide binding]; other site 364106010343 GTP/Mg2+ binding site [chemical binding]; other site 364106010344 Switch I region; other site 364106010345 G2 box; other site 364106010346 G3 box; other site 364106010347 Switch II region; other site 364106010348 G4 box; other site 364106010349 G5 box; other site 364106010350 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 364106010351 Translation-initiation factor 2; Region: IF-2; pfam11987 364106010352 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 364106010353 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 364106010354 NusA N-terminal domain; Region: NusA_N; pfam08529 364106010355 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 364106010356 RNA binding site [nucleotide binding]; other site 364106010357 homodimer interface [polypeptide binding]; other site 364106010358 NusA-like KH domain; Region: KH_5; pfam13184 364106010359 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 364106010360 G-X-X-G motif; other site 364106010361 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 364106010362 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 364106010363 ribosome maturation protein RimP; Reviewed; Region: PRK00092 364106010364 Sm and related proteins; Region: Sm_like; cl00259 364106010365 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 364106010366 putative oligomer interface [polypeptide binding]; other site 364106010367 putative RNA binding site [nucleotide binding]; other site 364106010368 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 364106010369 ANP binding site [chemical binding]; other site 364106010370 Substrate Binding Site II [chemical binding]; other site 364106010371 Substrate Binding Site I [chemical binding]; other site 364106010372 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 364106010373 Sulfatase; Region: Sulfatase; pfam00884 364106010374 Preprotein translocase SecG subunit; Region: SecG; pfam03840 364106010375 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 364106010376 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 364106010377 active site 364106010378 substrate binding site [chemical binding]; other site 364106010379 metal binding site [ion binding]; metal-binding site 364106010380 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 364106010381 dihydropteroate synthase; Region: DHPS; TIGR01496 364106010382 substrate binding pocket [chemical binding]; other site 364106010383 dimer interface [polypeptide binding]; other site 364106010384 inhibitor binding site; inhibition site 364106010385 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 364106010386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106010387 Walker A motif; other site 364106010388 ATP binding site [chemical binding]; other site 364106010389 Walker B motif; other site 364106010390 arginine finger; other site 364106010391 Peptidase family M41; Region: Peptidase_M41; pfam01434 364106010392 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 364106010393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106010394 S-adenosylmethionine binding site [chemical binding]; other site 364106010395 RNA-binding protein YhbY; Provisional; Region: PRK10343 364106010396 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 364106010397 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 364106010398 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 364106010399 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 364106010400 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 364106010401 GTPase CgtA; Reviewed; Region: obgE; PRK12298 364106010402 GTP1/OBG; Region: GTP1_OBG; pfam01018 364106010403 Obg GTPase; Region: Obg; cd01898 364106010404 G1 box; other site 364106010405 GTP/Mg2+ binding site [chemical binding]; other site 364106010406 Switch I region; other site 364106010407 G2 box; other site 364106010408 G3 box; other site 364106010409 Switch II region; other site 364106010410 G4 box; other site 364106010411 G5 box; other site 364106010412 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 364106010413 EamA-like transporter family; Region: EamA; pfam00892 364106010414 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 364106010415 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 364106010416 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 364106010417 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 364106010418 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 364106010419 substrate binding pocket [chemical binding]; other site 364106010420 chain length determination region; other site 364106010421 substrate-Mg2+ binding site; other site 364106010422 catalytic residues [active] 364106010423 aspartate-rich region 1; other site 364106010424 active site lid residues [active] 364106010425 aspartate-rich region 2; other site 364106010426 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 364106010427 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 364106010428 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 364106010429 hinge; other site 364106010430 active site 364106010431 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 364106010432 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 364106010433 anti sigma factor interaction site; other site 364106010434 regulatory phosphorylation site [posttranslational modification]; other site 364106010435 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 364106010436 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 364106010437 mce related protein; Region: MCE; pfam02470 364106010438 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 364106010439 conserved hypothetical integral membrane protein; Region: TIGR00056 364106010440 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 364106010441 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 364106010442 Walker A/P-loop; other site 364106010443 ATP binding site [chemical binding]; other site 364106010444 Q-loop/lid; other site 364106010445 ABC transporter signature motif; other site 364106010446 Walker B; other site 364106010447 D-loop; other site 364106010448 H-loop/switch region; other site 364106010449 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 364106010450 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 364106010451 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 364106010452 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 364106010453 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 364106010454 putative active site [active] 364106010455 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 364106010456 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 364106010457 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 364106010458 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 364106010459 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 364106010460 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 364106010461 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 364106010462 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 364106010463 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 364106010464 Walker A/P-loop; other site 364106010465 ATP binding site [chemical binding]; other site 364106010466 Q-loop/lid; other site 364106010467 ABC transporter signature motif; other site 364106010468 Walker B; other site 364106010469 D-loop; other site 364106010470 H-loop/switch region; other site 364106010471 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 364106010472 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 364106010473 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 364106010474 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 364106010475 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 364106010476 30S subunit binding site; other site 364106010477 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 364106010478 active site 364106010479 phosphorylation site [posttranslational modification] 364106010480 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 364106010481 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 364106010482 dimerization domain swap beta strand [polypeptide binding]; other site 364106010483 regulatory protein interface [polypeptide binding]; other site 364106010484 active site 364106010485 regulatory phosphorylation site [posttranslational modification]; other site 364106010486 hypothetical protein; Provisional; Region: PRK10345 364106010487 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 364106010488 Transglycosylase; Region: Transgly; cl17702 364106010489 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 364106010490 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 364106010491 conserved cys residue [active] 364106010492 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 364106010493 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 364106010494 putative active site [active] 364106010495 heme pocket [chemical binding]; other site 364106010496 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 364106010497 dimer interface [polypeptide binding]; other site 364106010498 phosphorylation site [posttranslational modification] 364106010499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106010500 ATP binding site [chemical binding]; other site 364106010501 Mg2+ binding site [ion binding]; other site 364106010502 G-X-G motif; other site 364106010503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106010504 active site 364106010505 phosphorylation site [posttranslational modification] 364106010506 intermolecular recognition site; other site 364106010507 dimerization interface [polypeptide binding]; other site 364106010508 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 364106010509 putative binding surface; other site 364106010510 active site 364106010511 radical SAM protein, TIGR01212 family; Region: TIGR01212 364106010512 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 364106010513 FeS/SAM binding site; other site 364106010514 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 364106010515 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 364106010516 active site 364106010517 dimer interface [polypeptide binding]; other site 364106010518 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 364106010519 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 364106010520 active site 364106010521 FMN binding site [chemical binding]; other site 364106010522 substrate binding site [chemical binding]; other site 364106010523 3Fe-4S cluster binding site [ion binding]; other site 364106010524 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 364106010525 domain interface; other site 364106010526 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 364106010527 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 364106010528 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 364106010529 Domain of unknown function (DUF386); Region: DUF386; cl01047 364106010530 N-acetylmannosamine kinase; Provisional; Region: PRK05082 364106010531 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 364106010532 nucleotide binding site [chemical binding]; other site 364106010533 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 364106010534 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 364106010535 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 364106010536 putative active site cavity [active] 364106010537 putative sialic acid transporter; Provisional; Region: PRK03893 364106010538 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106010539 putative substrate translocation pore; other site 364106010540 N-acetylneuraminate lyase; Region: nanA; TIGR00683 364106010541 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 364106010542 inhibitor site; inhibition site 364106010543 active site 364106010544 dimer interface [polypeptide binding]; other site 364106010545 catalytic residue [active] 364106010546 transcriptional regulator NanR; Provisional; Region: PRK03837 364106010547 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 364106010548 DNA-binding site [nucleotide binding]; DNA binding site 364106010549 FCD domain; Region: FCD; pfam07729 364106010550 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 364106010551 stringent starvation protein A; Provisional; Region: sspA; PRK09481 364106010552 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 364106010553 C-terminal domain interface [polypeptide binding]; other site 364106010554 putative GSH binding site (G-site) [chemical binding]; other site 364106010555 dimer interface [polypeptide binding]; other site 364106010556 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 364106010557 dimer interface [polypeptide binding]; other site 364106010558 N-terminal domain interface [polypeptide binding]; other site 364106010559 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 364106010560 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 364106010561 23S rRNA interface [nucleotide binding]; other site 364106010562 L3 interface [polypeptide binding]; other site 364106010563 Predicted ATPase [General function prediction only]; Region: COG1485 364106010564 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 364106010565 hypothetical protein; Provisional; Region: PRK11677 364106010566 serine endoprotease; Provisional; Region: PRK10139 364106010567 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 364106010568 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 364106010569 protein binding site [polypeptide binding]; other site 364106010570 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 364106010571 serine endoprotease; Provisional; Region: PRK10898 364106010572 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 364106010573 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 364106010574 malate dehydrogenase; Provisional; Region: PRK05086 364106010575 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 364106010576 NAD binding site [chemical binding]; other site 364106010577 dimerization interface [polypeptide binding]; other site 364106010578 Substrate binding site [chemical binding]; other site 364106010579 arginine repressor; Provisional; Region: PRK05066 364106010580 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 364106010581 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 364106010582 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 364106010583 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 364106010584 RNAase interaction site [polypeptide binding]; other site 364106010585 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 364106010586 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 364106010587 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 364106010588 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 364106010589 HlyD family secretion protein; Region: HlyD_3; pfam13437 364106010590 efflux system membrane protein; Provisional; Region: PRK11594 364106010591 transcriptional regulator; Provisional; Region: PRK10632 364106010592 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106010593 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 364106010594 putative effector binding pocket; other site 364106010595 dimerization interface [polypeptide binding]; other site 364106010596 protease TldD; Provisional; Region: tldD; PRK10735 364106010597 hypothetical protein; Provisional; Region: PRK10899 364106010598 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 364106010599 ribonuclease G; Provisional; Region: PRK11712 364106010600 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 364106010601 homodimer interface [polypeptide binding]; other site 364106010602 oligonucleotide binding site [chemical binding]; other site 364106010603 Maf-like protein; Region: Maf; pfam02545 364106010604 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 364106010605 active site 364106010606 dimer interface [polypeptide binding]; other site 364106010607 rod shape-determining protein MreD; Provisional; Region: PRK11060 364106010608 rod shape-determining protein MreC; Region: mreC; TIGR00219 364106010609 rod shape-determining protein MreC; Region: MreC; pfam04085 364106010610 rod shape-determining protein MreB; Provisional; Region: PRK13927 364106010611 MreB and similar proteins; Region: MreB_like; cd10225 364106010612 nucleotide binding site [chemical binding]; other site 364106010613 Mg binding site [ion binding]; other site 364106010614 putative protofilament interaction site [polypeptide binding]; other site 364106010615 RodZ interaction site [polypeptide binding]; other site 364106010616 regulatory protein CsrD; Provisional; Region: PRK11059 364106010617 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 364106010618 metal binding site [ion binding]; metal-binding site 364106010619 active site 364106010620 I-site; other site 364106010621 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 364106010622 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 364106010623 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 364106010624 NADP binding site [chemical binding]; other site 364106010625 dimer interface [polypeptide binding]; other site 364106010626 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 364106010627 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 364106010628 carboxyltransferase (CT) interaction site; other site 364106010629 biotinylation site [posttranslational modification]; other site 364106010630 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 364106010631 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 364106010632 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 364106010633 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 364106010634 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 364106010635 active site 364106010636 catalytic residues [active] 364106010637 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 364106010638 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 364106010639 substrate binding site [chemical binding]; other site 364106010640 ATP binding site [chemical binding]; other site 364106010641 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 364106010642 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 364106010643 TM-ABC transporter signature motif; other site 364106010644 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 364106010645 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 364106010646 Walker A/P-loop; other site 364106010647 ATP binding site [chemical binding]; other site 364106010648 Q-loop/lid; other site 364106010649 ABC transporter signature motif; other site 364106010650 Walker B; other site 364106010651 D-loop; other site 364106010652 H-loop/switch region; other site 364106010653 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 364106010654 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 364106010655 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_12; cd06322 364106010656 putative ligand binding site [chemical binding]; other site 364106010657 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 364106010658 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 364106010659 intersubunit interface [polypeptide binding]; other site 364106010660 active site 364106010661 zinc binding site [ion binding]; other site 364106010662 Na+ binding site [ion binding]; other site 364106010663 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 364106010664 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 364106010665 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 364106010666 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 364106010667 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 364106010668 substrate binding site [chemical binding]; other site 364106010669 ATP binding site [chemical binding]; other site 364106010670 hypothetical protein; Provisional; Region: PRK10633 364106010671 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 364106010672 Na binding site [ion binding]; other site 364106010673 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 364106010674 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 364106010675 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 364106010676 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 364106010677 FMN binding site [chemical binding]; other site 364106010678 active site 364106010679 catalytic residues [active] 364106010680 substrate binding site [chemical binding]; other site 364106010681 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 364106010682 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 364106010683 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 364106010684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106010685 DNA methylase; Region: N6_N4_Mtase; pfam01555 364106010686 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 364106010687 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 364106010688 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 364106010689 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 364106010690 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 364106010691 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 364106010692 HlyD family secretion protein; Region: HlyD_3; pfam13437 364106010693 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 364106010694 Protein export membrane protein; Region: SecD_SecF; cl14618 364106010695 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 364106010696 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 364106010697 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 364106010698 substrate binding pocket [chemical binding]; other site 364106010699 membrane-bound complex binding site; other site 364106010700 hinge residues; other site 364106010701 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 364106010702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106010703 conserved gate region; other site 364106010704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106010705 dimer interface [polypeptide binding]; other site 364106010706 conserved gate region; other site 364106010707 putative PBP binding loops; other site 364106010708 ABC-ATPase subunit interface; other site 364106010709 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 364106010710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106010711 dimer interface [polypeptide binding]; other site 364106010712 conserved gate region; other site 364106010713 putative PBP binding loops; other site 364106010714 ABC-ATPase subunit interface; other site 364106010715 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 364106010716 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 364106010717 Walker A/P-loop; other site 364106010718 ATP binding site [chemical binding]; other site 364106010719 Q-loop/lid; other site 364106010720 ABC transporter signature motif; other site 364106010721 Walker B; other site 364106010722 D-loop; other site 364106010723 H-loop/switch region; other site 364106010724 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 364106010725 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 364106010726 trimer interface [polypeptide binding]; other site 364106010727 putative metal binding site [ion binding]; other site 364106010728 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 364106010729 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 364106010730 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 364106010731 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 364106010732 shikimate binding site; other site 364106010733 NAD(P) binding site [chemical binding]; other site 364106010734 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 364106010735 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 364106010736 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 364106010737 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 364106010738 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 364106010739 hypothetical protein; Validated; Region: PRK03430 364106010740 hypothetical protein; Provisional; Region: PRK10736 364106010741 DNA protecting protein DprA; Region: dprA; TIGR00732 364106010742 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 364106010743 active site 364106010744 catalytic residues [active] 364106010745 metal binding site [ion binding]; metal-binding site 364106010746 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 364106010747 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 364106010748 putative active site [active] 364106010749 substrate binding site [chemical binding]; other site 364106010750 putative cosubstrate binding site; other site 364106010751 catalytic site [active] 364106010752 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 364106010753 substrate binding site [chemical binding]; other site 364106010754 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 364106010755 putative RNA binding site [nucleotide binding]; other site 364106010756 16S rRNA methyltransferase B; Provisional; Region: PRK10901 364106010757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106010758 S-adenosylmethionine binding site [chemical binding]; other site 364106010759 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 364106010760 TrkA-N domain; Region: TrkA_N; pfam02254 364106010761 TrkA-C domain; Region: TrkA_C; pfam02080 364106010762 TrkA-N domain; Region: TrkA_N; pfam02254 364106010763 TrkA-C domain; Region: TrkA_C; pfam02080 364106010764 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 364106010765 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 364106010766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 364106010767 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 364106010768 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 364106010769 DNA binding residues [nucleotide binding] 364106010770 dimer interface [polypeptide binding]; other site 364106010771 metal binding site [ion binding]; metal-binding site 364106010772 hypothetical protein; Provisional; Region: PRK10203 364106010773 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 364106010774 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 364106010775 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 364106010776 alphaNTD homodimer interface [polypeptide binding]; other site 364106010777 alphaNTD - beta interaction site [polypeptide binding]; other site 364106010778 alphaNTD - beta' interaction site [polypeptide binding]; other site 364106010779 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 364106010780 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 364106010781 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 364106010782 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 364106010783 RNA binding surface [nucleotide binding]; other site 364106010784 30S ribosomal protein S11; Validated; Region: PRK05309 364106010785 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 364106010786 30S ribosomal protein S13; Region: bact_S13; TIGR03631 364106010787 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 364106010788 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 364106010789 SecY translocase; Region: SecY; pfam00344 364106010790 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 364106010791 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 364106010792 23S rRNA binding site [nucleotide binding]; other site 364106010793 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 364106010794 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 364106010795 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 364106010796 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 364106010797 23S rRNA interface [nucleotide binding]; other site 364106010798 5S rRNA interface [nucleotide binding]; other site 364106010799 L27 interface [polypeptide binding]; other site 364106010800 L5 interface [polypeptide binding]; other site 364106010801 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 364106010802 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 364106010803 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 364106010804 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 364106010805 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 364106010806 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 364106010807 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 364106010808 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 364106010809 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 364106010810 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 364106010811 RNA binding site [nucleotide binding]; other site 364106010812 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 364106010813 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 364106010814 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 364106010815 23S rRNA interface [nucleotide binding]; other site 364106010816 putative translocon interaction site; other site 364106010817 signal recognition particle (SRP54) interaction site; other site 364106010818 L23 interface [polypeptide binding]; other site 364106010819 trigger factor interaction site; other site 364106010820 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 364106010821 23S rRNA interface [nucleotide binding]; other site 364106010822 5S rRNA interface [nucleotide binding]; other site 364106010823 putative antibiotic binding site [chemical binding]; other site 364106010824 L25 interface [polypeptide binding]; other site 364106010825 L27 interface [polypeptide binding]; other site 364106010826 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 364106010827 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 364106010828 G-X-X-G motif; other site 364106010829 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 364106010830 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 364106010831 protein-rRNA interface [nucleotide binding]; other site 364106010832 putative translocon binding site; other site 364106010833 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 364106010834 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 364106010835 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 364106010836 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 364106010837 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 364106010838 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 364106010839 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 364106010840 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 364106010841 protein secretion protein GspB; Provisional; Region: PRK09697 364106010842 AAA domain; Region: AAA_22; pfam13401 364106010843 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 364106010844 Type II secretory pathway, component PulC [Intracellular trafficking and secretion]; Region: PulC; COG3031 364106010845 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 364106010846 type II secretion system protein D; Region: type_II_gspD; TIGR02517 364106010847 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 364106010848 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 364106010849 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 364106010850 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 364106010851 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 364106010852 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 364106010853 Walker A motif; other site 364106010854 ATP binding site [chemical binding]; other site 364106010855 Walker B motif; other site 364106010856 type II secretion system protein F; Region: GspF; TIGR02120 364106010857 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 364106010858 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 364106010859 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 364106010860 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 364106010861 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 364106010862 Type II transport protein GspH; Region: GspH; pfam12019 364106010863 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 364106010864 type II secretion system protein I; Region: gspI; TIGR01707 364106010865 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 364106010866 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 364106010867 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 364106010868 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 364106010869 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 364106010870 Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297 364106010871 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 364106010872 GspL periplasmic domain; Region: GspL_C; pfam12693 364106010873 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 364106010874 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 364106010875 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 364106010876 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 364106010877 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 364106010878 heme binding site [chemical binding]; other site 364106010879 ferroxidase pore; other site 364106010880 ferroxidase diiron center [ion binding]; other site 364106010881 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 364106010882 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 364106010883 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 364106010884 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 364106010885 aromatic chitin/cellulose binding site residues [chemical binding]; other site 364106010886 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 364106010887 active site 364106010888 elongation factor Tu; Reviewed; Region: PRK00049 364106010889 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 364106010890 G1 box; other site 364106010891 GEF interaction site [polypeptide binding]; other site 364106010892 GTP/Mg2+ binding site [chemical binding]; other site 364106010893 Switch I region; other site 364106010894 G2 box; other site 364106010895 G3 box; other site 364106010896 Switch II region; other site 364106010897 G4 box; other site 364106010898 G5 box; other site 364106010899 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 364106010900 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 364106010901 Antibiotic Binding Site [chemical binding]; other site 364106010902 pantothenate kinase; Provisional; Region: PRK05439 364106010903 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 364106010904 ATP-binding site [chemical binding]; other site 364106010905 CoA-binding site [chemical binding]; other site 364106010906 Mg2+-binding site [ion binding]; other site 364106010907 Biotin operon repressor [Transcription]; Region: BirA; COG1654 364106010908 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 364106010909 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 364106010910 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 364106010911 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 364106010912 FAD binding domain; Region: FAD_binding_4; pfam01565 364106010913 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 364106010914 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 364106010915 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 364106010916 purine monophosphate binding site [chemical binding]; other site 364106010917 dimer interface [polypeptide binding]; other site 364106010918 putative catalytic residues [active] 364106010919 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 364106010920 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 364106010921 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 364106010922 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 364106010923 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 364106010924 sensor protein ZraS; Provisional; Region: PRK10364 364106010925 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 364106010926 dimer interface [polypeptide binding]; other site 364106010927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106010928 ATP binding site [chemical binding]; other site 364106010929 Mg2+ binding site [ion binding]; other site 364106010930 G-X-G motif; other site 364106010931 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 364106010932 dimer interface [polypeptide binding]; other site 364106010933 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 364106010934 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 364106010935 IHF dimer interface [polypeptide binding]; other site 364106010936 IHF - DNA interface [nucleotide binding]; other site 364106010937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 364106010938 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 364106010939 Active_site [active] 364106010940 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 364106010941 substrate binding site [chemical binding]; other site 364106010942 active site 364106010943 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 364106010944 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 364106010945 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 364106010946 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 364106010947 putative NADH binding site [chemical binding]; other site 364106010948 putative active site [active] 364106010949 nudix motif; other site 364106010950 putative metal binding site [ion binding]; other site 364106010951 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 364106010952 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 364106010953 ThiC-associated domain; Region: ThiC-associated; pfam13667 364106010954 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 364106010955 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 364106010956 thiamine phosphate binding site [chemical binding]; other site 364106010957 active site 364106010958 pyrophosphate binding site [ion binding]; other site 364106010959 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 364106010960 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 364106010961 ATP binding site [chemical binding]; other site 364106010962 substrate interface [chemical binding]; other site 364106010963 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 364106010964 thiS-thiF/thiG interaction site; other site 364106010965 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 364106010966 ThiS interaction site; other site 364106010967 putative active site [active] 364106010968 tetramer interface [polypeptide binding]; other site 364106010969 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 364106010970 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 364106010971 FeS/SAM binding site; other site 364106010972 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 364106010973 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 364106010974 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 364106010975 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 364106010976 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 364106010977 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 364106010978 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 364106010979 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 364106010980 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 364106010981 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 364106010982 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 364106010983 DNA binding site [nucleotide binding] 364106010984 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 364106010985 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 364106010986 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 364106010987 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 364106010988 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 364106010989 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 364106010990 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 364106010991 RPB3 interaction site [polypeptide binding]; other site 364106010992 RPB1 interaction site [polypeptide binding]; other site 364106010993 RPB11 interaction site [polypeptide binding]; other site 364106010994 RPB10 interaction site [polypeptide binding]; other site 364106010995 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 364106010996 core dimer interface [polypeptide binding]; other site 364106010997 peripheral dimer interface [polypeptide binding]; other site 364106010998 L10 interface [polypeptide binding]; other site 364106010999 L11 interface [polypeptide binding]; other site 364106011000 putative EF-Tu interaction site [polypeptide binding]; other site 364106011001 putative EF-G interaction site [polypeptide binding]; other site 364106011002 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 364106011003 23S rRNA interface [nucleotide binding]; other site 364106011004 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 364106011005 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 364106011006 mRNA/rRNA interface [nucleotide binding]; other site 364106011007 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 364106011008 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 364106011009 23S rRNA interface [nucleotide binding]; other site 364106011010 L7/L12 interface [polypeptide binding]; other site 364106011011 putative thiostrepton binding site; other site 364106011012 L25 interface [polypeptide binding]; other site 364106011013 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 364106011014 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 364106011015 putative homodimer interface [polypeptide binding]; other site 364106011016 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 364106011017 heterodimer interface [polypeptide binding]; other site 364106011018 homodimer interface [polypeptide binding]; other site 364106011019 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 364106011020 elongation factor Tu; Reviewed; Region: PRK00049 364106011021 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 364106011022 G1 box; other site 364106011023 GEF interaction site [polypeptide binding]; other site 364106011024 GTP/Mg2+ binding site [chemical binding]; other site 364106011025 Switch I region; other site 364106011026 G2 box; other site 364106011027 G3 box; other site 364106011028 Switch II region; other site 364106011029 G4 box; other site 364106011030 G5 box; other site 364106011031 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 364106011032 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 364106011033 Antibiotic Binding Site [chemical binding]; other site 364106011034 elongation factor G; Reviewed; Region: PRK00007 364106011035 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 364106011036 G1 box; other site 364106011037 putative GEF interaction site [polypeptide binding]; other site 364106011038 GTP/Mg2+ binding site [chemical binding]; other site 364106011039 Switch I region; other site 364106011040 G2 box; other site 364106011041 G3 box; other site 364106011042 Switch II region; other site 364106011043 G4 box; other site 364106011044 G5 box; other site 364106011045 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 364106011046 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 364106011047 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 364106011048 30S ribosomal protein S7; Validated; Region: PRK05302 364106011049 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 364106011050 S17 interaction site [polypeptide binding]; other site 364106011051 S8 interaction site; other site 364106011052 16S rRNA interaction site [nucleotide binding]; other site 364106011053 streptomycin interaction site [chemical binding]; other site 364106011054 23S rRNA interaction site [nucleotide binding]; other site 364106011055 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 364106011056 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 364106011057 sulfur relay protein TusC; Validated; Region: PRK00211 364106011058 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 364106011059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 364106011060 YheO-like PAS domain; Region: PAS_6; pfam08348 364106011061 HTH domain; Region: HTH_22; pfam13309 364106011062 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 364106011063 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 364106011064 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 364106011065 phi X174 lysis protein; Provisional; Region: PRK02793 364106011066 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 364106011067 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 364106011068 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 364106011069 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 364106011070 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 364106011071 TrkA-N domain; Region: TrkA_N; pfam02254 364106011072 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 364106011073 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 364106011074 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 364106011075 Walker A/P-loop; other site 364106011076 ATP binding site [chemical binding]; other site 364106011077 Q-loop/lid; other site 364106011078 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 364106011079 ABC transporter signature motif; other site 364106011080 Walker B; other site 364106011081 D-loop; other site 364106011082 ABC transporter; Region: ABC_tran_2; pfam12848 364106011083 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 364106011084 putative hydrolase; Provisional; Region: PRK10985 364106011085 hypothetical protein; Provisional; Region: PRK04966 364106011086 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 364106011087 active site 364106011088 hypothetical protein; Provisional; Region: PRK10738 364106011089 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 364106011090 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 364106011091 ligand binding site [chemical binding]; other site 364106011092 flexible hinge region; other site 364106011093 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 364106011094 putative switch regulator; other site 364106011095 non-specific DNA interactions [nucleotide binding]; other site 364106011096 DNA binding site [nucleotide binding] 364106011097 sequence specific DNA binding site [nucleotide binding]; other site 364106011098 putative cAMP binding site [chemical binding]; other site 364106011099 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 364106011100 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 364106011101 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 364106011102 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 364106011103 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 364106011104 inhibitor-cofactor binding pocket; inhibition site 364106011105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106011106 catalytic residue [active] 364106011107 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 364106011108 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 364106011109 glutamine binding [chemical binding]; other site 364106011110 catalytic triad [active] 364106011111 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 364106011112 cell filamentation protein Fic; Provisional; Region: PRK10347 364106011113 hypothetical protein; Provisional; Region: PRK10204 364106011114 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 364106011115 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 364106011116 substrate binding site [chemical binding]; other site 364106011117 putative transporter; Provisional; Region: PRK03699 364106011118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106011119 putative substrate translocation pore; other site 364106011120 nitrite reductase subunit NirD; Provisional; Region: PRK14989 364106011121 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 364106011122 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 364106011123 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 364106011124 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 364106011125 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 364106011126 nitrite transporter NirC; Provisional; Region: PRK11562 364106011127 siroheme synthase; Provisional; Region: cysG; PRK10637 364106011128 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 364106011129 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 364106011130 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 364106011131 active site 364106011132 SAM binding site [chemical binding]; other site 364106011133 homodimer interface [polypeptide binding]; other site 364106011134 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 364106011135 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 364106011136 Protein of unknown function; Region: YhfT; pfam10797 364106011137 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 364106011138 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 364106011139 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 364106011140 active site 364106011141 substrate binding pocket [chemical binding]; other site 364106011142 homodimer interaction site [polypeptide binding]; other site 364106011143 putative mutase; Provisional; Region: PRK12383 364106011144 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015 364106011145 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 364106011146 dimer interface [polypeptide binding]; other site 364106011147 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 364106011148 active site 364106011149 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 364106011150 substrate binding site [chemical binding]; other site 364106011151 catalytic residue [active] 364106011152 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 364106011153 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 364106011154 active site 364106011155 HIGH motif; other site 364106011156 dimer interface [polypeptide binding]; other site 364106011157 KMSKS motif; other site 364106011158 phosphoglycolate phosphatase; Provisional; Region: PRK13222 364106011159 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 364106011160 motif II; other site 364106011161 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 364106011162 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 364106011163 substrate binding site [chemical binding]; other site 364106011164 hexamer interface [polypeptide binding]; other site 364106011165 metal binding site [ion binding]; metal-binding site 364106011166 DNA adenine methylase; Provisional; Region: PRK10904 364106011167 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 364106011168 cell division protein DamX; Validated; Region: PRK10905 364106011169 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 364106011170 active site 364106011171 dimer interface [polypeptide binding]; other site 364106011172 metal binding site [ion binding]; metal-binding site 364106011173 shikimate kinase; Reviewed; Region: aroK; PRK00131 364106011174 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 364106011175 ADP binding site [chemical binding]; other site 364106011176 magnesium binding site [ion binding]; other site 364106011177 putative shikimate binding site; other site 364106011178 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 364106011179 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 364106011180 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 364106011181 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 364106011182 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 364106011183 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 364106011184 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 364106011185 Transglycosylase; Region: Transgly; pfam00912 364106011186 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 364106011187 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 364106011188 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 364106011189 ADP-ribose binding site [chemical binding]; other site 364106011190 dimer interface [polypeptide binding]; other site 364106011191 active site 364106011192 nudix motif; other site 364106011193 metal binding site [ion binding]; metal-binding site 364106011194 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 364106011195 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 364106011196 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 364106011197 motif II; other site 364106011198 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 364106011199 RNA binding surface [nucleotide binding]; other site 364106011200 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 364106011201 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 364106011202 dimerization interface [polypeptide binding]; other site 364106011203 domain crossover interface; other site 364106011204 redox-dependent activation switch; other site 364106011205 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 364106011206 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 364106011207 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 364106011208 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 364106011209 active site 364106011210 substrate-binding site [chemical binding]; other site 364106011211 metal-binding site [ion binding] 364106011212 ATP binding site [chemical binding]; other site 364106011213 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 364106011214 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 364106011215 dimerization interface [polypeptide binding]; other site 364106011216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 364106011217 dimer interface [polypeptide binding]; other site 364106011218 phosphorylation site [posttranslational modification] 364106011219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106011220 ATP binding site [chemical binding]; other site 364106011221 G-X-G motif; other site 364106011222 osmolarity response regulator; Provisional; Region: ompR; PRK09468 364106011223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106011224 active site 364106011225 phosphorylation site [posttranslational modification] 364106011226 intermolecular recognition site; other site 364106011227 dimerization interface [polypeptide binding]; other site 364106011228 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 364106011229 DNA binding site [nucleotide binding] 364106011230 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 364106011231 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 364106011232 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 364106011233 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 364106011234 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 364106011235 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 364106011236 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 364106011237 RNA binding site [nucleotide binding]; other site 364106011238 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 364106011239 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 364106011240 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 364106011241 G1 box; other site 364106011242 GTP/Mg2+ binding site [chemical binding]; other site 364106011243 Switch I region; other site 364106011244 G2 box; other site 364106011245 G3 box; other site 364106011246 Switch II region; other site 364106011247 G4 box; other site 364106011248 G5 box; other site 364106011249 Nucleoside recognition; Region: Gate; pfam07670 364106011250 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 364106011251 Nucleoside recognition; Region: Gate; pfam07670 364106011252 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 364106011253 putative transposase; Provisional; Region: PRK09857 364106011254 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 364106011255 carboxylesterase BioH; Provisional; Region: PRK10349 364106011256 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 364106011257 DNA utilization protein GntX; Provisional; Region: PRK11595 364106011258 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 364106011259 active site 364106011260 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 364106011261 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 364106011262 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 364106011263 high-affinity gluconate transporter; Provisional; Region: PRK14984 364106011264 gluconate transporter; Region: gntP; TIGR00791 364106011265 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 364106011266 4-alpha-glucanotransferase; Region: malQ; TIGR00217 364106011267 maltodextrin phosphorylase; Provisional; Region: PRK14985 364106011268 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 364106011269 homodimer interface [polypeptide binding]; other site 364106011270 active site pocket [active] 364106011271 transcriptional regulator MalT; Provisional; Region: PRK04841 364106011272 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 364106011273 DNA binding residues [nucleotide binding] 364106011274 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 364106011275 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 364106011276 putative active site [active] 364106011277 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 364106011278 hypothetical protein; Reviewed; Region: PRK09588 364106011279 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 364106011280 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 364106011281 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106011282 Walker A motif; other site 364106011283 ATP binding site [chemical binding]; other site 364106011284 Walker B motif; other site 364106011285 arginine finger; other site 364106011286 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 364106011287 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 364106011288 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 364106011289 intramembrane serine protease GlpG; Provisional; Region: PRK10907 364106011290 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 364106011291 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 364106011292 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 364106011293 active site residue [active] 364106011294 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 364106011295 hypothetical protein; Provisional; Region: PRK09781; cl08057 364106011296 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 364106011297 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 364106011298 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 364106011299 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 364106011300 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 364106011301 outer membrane usher protein; Provisional; Region: PRK15193 364106011302 PapC N-terminal domain; Region: PapC_N; pfam13954 364106011303 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 364106011304 PapC C-terminal domain; Region: PapC_C; pfam13953 364106011305 fimbrial chaperone protein StiB; Provisional; Region: PRK15299 364106011306 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 364106011307 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 364106011308 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 364106011309 glycogen phosphorylase; Provisional; Region: PRK14986 364106011310 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 364106011311 homodimer interface [polypeptide binding]; other site 364106011312 active site pocket [active] 364106011313 glycogen synthase; Provisional; Region: glgA; PRK00654 364106011314 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 364106011315 ADP-binding pocket [chemical binding]; other site 364106011316 homodimer interface [polypeptide binding]; other site 364106011317 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 364106011318 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 364106011319 ligand binding site; other site 364106011320 oligomer interface; other site 364106011321 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 364106011322 sulfate 1 binding site; other site 364106011323 glycogen debranching enzyme; Provisional; Region: PRK03705 364106011324 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 364106011325 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 364106011326 active site 364106011327 catalytic site [active] 364106011328 glycogen branching enzyme; Provisional; Region: PRK05402 364106011329 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 364106011330 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 364106011331 active site 364106011332 catalytic site [active] 364106011333 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 364106011334 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 364106011335 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 364106011336 putative antibiotic transporter; Provisional; Region: PRK10739 364106011337 low affinity gluconate transporter; Provisional; Region: PRK10472 364106011338 gluconate transporter; Region: gntP; TIGR00791 364106011339 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 364106011340 ATP-binding site [chemical binding]; other site 364106011341 Gluconate-6-phosphate binding site [chemical binding]; other site 364106011342 Shikimate kinase; Region: SKI; pfam01202 364106011343 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 364106011344 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 364106011345 DNA binding site [nucleotide binding] 364106011346 domain linker motif; other site 364106011347 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 364106011348 putative ligand binding site [chemical binding]; other site 364106011349 putative dimerization interface [polypeptide binding]; other site 364106011350 Pirin-related protein [General function prediction only]; Region: COG1741 364106011351 Pirin; Region: Pirin; pfam02678 364106011352 putative oxidoreductase; Provisional; Region: PRK10206 364106011353 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 364106011354 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 364106011355 putative acetyltransferase YhhY; Provisional; Region: PRK10140 364106011356 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 364106011357 Coenzyme A binding pocket [chemical binding]; other site 364106011358 YopJ Serine/Threonine acetyltransferase; Region: YopJ; cl07849 364106011359 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 364106011360 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 364106011361 hypothetical protein; Provisional; Region: PRK10350 364106011362 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 364106011363 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 364106011364 putative active site [active] 364106011365 catalytic site [active] 364106011366 putative metal binding site [ion binding]; other site 364106011367 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 364106011368 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 364106011369 Walker A/P-loop; other site 364106011370 ATP binding site [chemical binding]; other site 364106011371 Q-loop/lid; other site 364106011372 ABC transporter signature motif; other site 364106011373 Walker B; other site 364106011374 D-loop; other site 364106011375 H-loop/switch region; other site 364106011376 TOBE domain; Region: TOBE_2; pfam08402 364106011377 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 364106011378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106011379 dimer interface [polypeptide binding]; other site 364106011380 conserved gate region; other site 364106011381 putative PBP binding loops; other site 364106011382 ABC-ATPase subunit interface; other site 364106011383 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 364106011384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106011385 dimer interface [polypeptide binding]; other site 364106011386 conserved gate region; other site 364106011387 putative PBP binding loops; other site 364106011388 ABC-ATPase subunit interface; other site 364106011389 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 364106011390 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 364106011391 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 364106011392 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 364106011393 Walker A/P-loop; other site 364106011394 ATP binding site [chemical binding]; other site 364106011395 Q-loop/lid; other site 364106011396 ABC transporter signature motif; other site 364106011397 Walker B; other site 364106011398 D-loop; other site 364106011399 H-loop/switch region; other site 364106011400 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 364106011401 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 364106011402 Walker A/P-loop; other site 364106011403 ATP binding site [chemical binding]; other site 364106011404 Q-loop/lid; other site 364106011405 ABC transporter signature motif; other site 364106011406 Walker B; other site 364106011407 D-loop; other site 364106011408 H-loop/switch region; other site 364106011409 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 364106011410 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 364106011411 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 364106011412 TM-ABC transporter signature motif; other site 364106011413 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 364106011414 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 364106011415 TM-ABC transporter signature motif; other site 364106011416 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 364106011417 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 364106011418 dimerization interface [polypeptide binding]; other site 364106011419 ligand binding site [chemical binding]; other site 364106011420 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 364106011421 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 364106011422 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 364106011423 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 364106011424 dimerization interface [polypeptide binding]; other site 364106011425 ligand binding site [chemical binding]; other site 364106011426 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 364106011427 active pocket/dimerization site; other site 364106011428 active site 364106011429 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 364106011430 active site 364106011431 phosphorylation site [posttranslational modification] 364106011432 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 364106011433 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 364106011434 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 364106011435 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 364106011436 putative ligand binding site [chemical binding]; other site 364106011437 putative NAD binding site [chemical binding]; other site 364106011438 catalytic site [active] 364106011439 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 364106011440 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 364106011441 inhibitor site; inhibition site 364106011442 active site 364106011443 dimer interface [polypeptide binding]; other site 364106011444 catalytic residue [active] 364106011445 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 364106011446 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 364106011447 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 364106011448 DNA binding residues [nucleotide binding] 364106011449 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 364106011450 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 364106011451 cell division protein FtsE; Provisional; Region: PRK10908 364106011452 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 364106011453 Walker A/P-loop; other site 364106011454 ATP binding site [chemical binding]; other site 364106011455 Q-loop/lid; other site 364106011456 ABC transporter signature motif; other site 364106011457 Walker B; other site 364106011458 D-loop; other site 364106011459 H-loop/switch region; other site 364106011460 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 364106011461 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 364106011462 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 364106011463 P loop; other site 364106011464 GTP binding site [chemical binding]; other site 364106011465 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 364106011466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106011467 S-adenosylmethionine binding site [chemical binding]; other site 364106011468 hypothetical protein; Provisional; Region: PRK10910 364106011469 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 364106011470 Predicted membrane protein [Function unknown]; Region: COG3714 364106011471 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 364106011472 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 364106011473 metal-binding site [ion binding] 364106011474 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 364106011475 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 364106011476 CPxP motif; other site 364106011477 hypothetical protein; Provisional; Region: PRK11212 364106011478 hypothetical protein; Provisional; Region: PRK11615 364106011479 major facilitator superfamily transporter; Provisional; Region: PRK05122 364106011480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106011481 putative substrate translocation pore; other site 364106011482 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 364106011483 Domain of unknown function DUF20; Region: UPF0118; pfam01594 364106011484 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 364106011485 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 364106011486 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 364106011487 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 364106011488 substrate binding site [chemical binding]; other site 364106011489 nickel transporter permease NikB; Provisional; Region: PRK10352 364106011490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106011491 dimer interface [polypeptide binding]; other site 364106011492 conserved gate region; other site 364106011493 putative PBP binding loops; other site 364106011494 ABC-ATPase subunit interface; other site 364106011495 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 364106011496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106011497 dimer interface [polypeptide binding]; other site 364106011498 conserved gate region; other site 364106011499 putative PBP binding loops; other site 364106011500 ABC-ATPase subunit interface; other site 364106011501 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 364106011502 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 364106011503 Walker A/P-loop; other site 364106011504 ATP binding site [chemical binding]; other site 364106011505 Q-loop/lid; other site 364106011506 ABC transporter signature motif; other site 364106011507 Walker B; other site 364106011508 D-loop; other site 364106011509 H-loop/switch region; other site 364106011510 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 364106011511 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 364106011512 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 364106011513 Walker A/P-loop; other site 364106011514 ATP binding site [chemical binding]; other site 364106011515 Q-loop/lid; other site 364106011516 ABC transporter signature motif; other site 364106011517 Walker B; other site 364106011518 D-loop; other site 364106011519 H-loop/switch region; other site 364106011520 nickel responsive regulator; Provisional; Region: PRK02967 364106011521 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 364106011522 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 364106011523 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 364106011524 DNA-binding site [nucleotide binding]; DNA binding site 364106011525 UTRA domain; Region: UTRA; pfam07702 364106011526 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 364106011527 active site 364106011528 phosphorylation site [posttranslational modification] 364106011529 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 364106011530 active site 364106011531 P-loop; other site 364106011532 phosphorylation site [posttranslational modification] 364106011533 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 364106011534 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 364106011535 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 364106011536 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 364106011537 putative N- and C-terminal domain interface [polypeptide binding]; other site 364106011538 putative active site [active] 364106011539 putative MgATP binding site [chemical binding]; other site 364106011540 catalytic site [active] 364106011541 metal binding site [ion binding]; metal-binding site 364106011542 putative carbohydrate binding site [chemical binding]; other site 364106011543 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 364106011544 dimerization domain swap beta strand [polypeptide binding]; other site 364106011545 regulatory protein interface [polypeptide binding]; other site 364106011546 active site 364106011547 regulatory phosphorylation site [posttranslational modification]; other site 364106011548 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 364106011549 intersubunit interface [polypeptide binding]; other site 364106011550 active site 364106011551 zinc binding site [ion binding]; other site 364106011552 Na+ binding site [ion binding]; other site 364106011553 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 364106011554 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 364106011555 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 364106011556 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 364106011557 Walker A/P-loop; other site 364106011558 ATP binding site [chemical binding]; other site 364106011559 Q-loop/lid; other site 364106011560 ABC transporter signature motif; other site 364106011561 Walker B; other site 364106011562 D-loop; other site 364106011563 H-loop/switch region; other site 364106011564 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 364106011565 Walker A/P-loop; other site 364106011566 ATP binding site [chemical binding]; other site 364106011567 Q-loop/lid; other site 364106011568 ABC transporter signature motif; other site 364106011569 Walker B; other site 364106011570 D-loop; other site 364106011571 H-loop/switch region; other site 364106011572 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 364106011573 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 364106011574 HlyD family secretion protein; Region: HlyD; pfam00529 364106011575 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 364106011576 HlyD family secretion protein; Region: HlyD_3; pfam13437 364106011577 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 364106011578 Predicted flavoproteins [General function prediction only]; Region: COG2081 364106011579 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 364106011580 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 364106011581 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 364106011582 universal stress protein UspB; Provisional; Region: PRK04960 364106011583 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 364106011584 Ligand Binding Site [chemical binding]; other site 364106011585 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 364106011586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106011587 POT family; Region: PTR2; pfam00854 364106011588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106011589 S-adenosylmethionine binding site [chemical binding]; other site 364106011590 oligopeptidase A; Provisional; Region: PRK10911 364106011591 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 364106011592 active site 364106011593 Zn binding site [ion binding]; other site 364106011594 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 364106011595 glutathione reductase; Validated; Region: PRK06116 364106011596 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 364106011597 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 364106011598 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 364106011599 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 364106011600 ArsC family; Region: ArsC; pfam03960 364106011601 catalytic residues [active] 364106011602 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 364106011603 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 364106011604 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 364106011605 DNA binding residues [nucleotide binding] 364106011606 dimerization interface [polypeptide binding]; other site 364106011607 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 364106011608 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 364106011609 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 364106011610 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 364106011611 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 364106011612 N-terminal plug; other site 364106011613 ligand-binding site [chemical binding]; other site 364106011614 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 364106011615 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 364106011616 putative hemin binding site; other site 364106011617 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 364106011618 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 364106011619 FeS/SAM binding site; other site 364106011620 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721 364106011621 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 364106011622 NADH(P)-binding; Region: NAD_binding_10; pfam13460 364106011623 NAD(P) binding site [chemical binding]; other site 364106011624 putative active site [active] 364106011625 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 364106011626 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 364106011627 ABC-ATPase subunit interface; other site 364106011628 dimer interface [polypeptide binding]; other site 364106011629 putative PBP binding regions; other site 364106011630 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 364106011631 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 364106011632 Walker A/P-loop; other site 364106011633 ATP binding site [chemical binding]; other site 364106011634 Q-loop/lid; other site 364106011635 ABC transporter signature motif; other site 364106011636 Walker B; other site 364106011637 D-loop; other site 364106011638 H-loop/switch region; other site 364106011639 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 364106011640 MgtC family; Region: MgtC; pfam02308 364106011641 acid-resistance protein; Provisional; Region: hdeB; PRK11566 364106011642 acid-resistance protein; Provisional; Region: PRK10208 364106011643 acid-resistance membrane protein; Provisional; Region: PRK10209 364106011644 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 364106011645 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 364106011646 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 364106011647 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 364106011648 HlyD family secretion protein; Region: HlyD_3; pfam13437 364106011649 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 364106011650 Protein export membrane protein; Region: SecD_SecF; cl14618 364106011651 transcriptional regulator YdeO; Provisional; Region: PRK09940 364106011652 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106011653 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 364106011654 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106011655 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 364106011656 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106011657 catalytic residue [active] 364106011658 Haem-binding domain; Region: Haem_bd; pfam14376 364106011659 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 364106011660 trehalase; Provisional; Region: treF; PRK13270 364106011661 Trehalase; Region: Trehalase; pfam01204 364106011662 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 364106011663 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 364106011664 DNA binding residues [nucleotide binding] 364106011665 dimerization interface [polypeptide binding]; other site 364106011666 Transcriptional regulator [Transcription]; Region: LysR; COG0583 364106011667 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106011668 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 364106011669 putative effector binding pocket; other site 364106011670 putative dimerization interface [polypeptide binding]; other site 364106011671 inner membrane protein YhjD; Region: TIGR00766 364106011672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106011673 metabolite-proton symporter; Region: 2A0106; TIGR00883 364106011674 putative substrate translocation pore; other site 364106011675 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 364106011676 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 364106011677 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 364106011678 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 364106011679 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 364106011680 substrate binding site [chemical binding]; other site 364106011681 ATP binding site [chemical binding]; other site 364106011682 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 364106011683 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 364106011684 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 364106011685 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 364106011686 putative diguanylate cyclase; Provisional; Region: PRK13561 364106011687 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 364106011688 metal binding site [ion binding]; metal-binding site 364106011689 active site 364106011690 I-site; other site 364106011691 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 364106011692 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 364106011693 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 364106011694 binding surface 364106011695 TPR motif; other site 364106011696 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 364106011697 binding surface 364106011698 TPR motif; other site 364106011699 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 364106011700 TPR motif; other site 364106011701 binding surface 364106011702 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 364106011703 endo-1,4-D-glucanase; Provisional; Region: PRK11097 364106011704 cellulose synthase regulator protein; Provisional; Region: PRK11114 364106011705 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 364106011706 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 364106011707 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 364106011708 DXD motif; other site 364106011709 PilZ domain; Region: PilZ; pfam07238 364106011710 cell division protein; Provisional; Region: PRK10037 364106011711 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 364106011712 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 364106011713 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 364106011714 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 364106011715 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 364106011716 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 364106011717 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 364106011718 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 364106011719 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 364106011720 serine transporter; Region: stp; TIGR00814 364106011721 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 364106011722 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 364106011723 Walker A/P-loop; other site 364106011724 ATP binding site [chemical binding]; other site 364106011725 Q-loop/lid; other site 364106011726 ABC transporter signature motif; other site 364106011727 Walker B; other site 364106011728 D-loop; other site 364106011729 H-loop/switch region; other site 364106011730 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 364106011731 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 364106011732 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 364106011733 Walker A/P-loop; other site 364106011734 ATP binding site [chemical binding]; other site 364106011735 Q-loop/lid; other site 364106011736 ABC transporter signature motif; other site 364106011737 Walker B; other site 364106011738 D-loop; other site 364106011739 H-loop/switch region; other site 364106011740 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 364106011741 dipeptide transporter; Provisional; Region: PRK10913 364106011742 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 364106011743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106011744 dimer interface [polypeptide binding]; other site 364106011745 conserved gate region; other site 364106011746 putative PBP binding loops; other site 364106011747 ABC-ATPase subunit interface; other site 364106011748 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 364106011749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106011750 dimer interface [polypeptide binding]; other site 364106011751 conserved gate region; other site 364106011752 putative PBP binding loops; other site 364106011753 ABC-ATPase subunit interface; other site 364106011754 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 364106011755 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 364106011756 peptide binding site [polypeptide binding]; other site 364106011757 phosphoethanolamine transferase; Provisional; Region: PRK11560 364106011758 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 364106011759 Sulfatase; Region: Sulfatase; pfam00884 364106011760 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 364106011761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106011762 putative substrate translocation pore; other site 364106011763 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 364106011764 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 364106011765 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 364106011766 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 364106011767 Coenzyme A binding pocket [chemical binding]; other site 364106011768 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 364106011769 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 364106011770 molybdopterin cofactor binding site [chemical binding]; other site 364106011771 substrate binding site [chemical binding]; other site 364106011772 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 364106011773 molybdopterin cofactor binding site; other site 364106011774 putative outer membrane lipoprotein; Provisional; Region: PRK10510 364106011775 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 364106011776 ligand binding site [chemical binding]; other site 364106011777 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 364106011778 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 364106011779 dimerization interface [polypeptide binding]; other site 364106011780 ligand binding site [chemical binding]; other site 364106011781 NADP binding site [chemical binding]; other site 364106011782 catalytic site [active] 364106011783 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 364106011784 Predicted transcriptional regulator [Transcription]; Region: COG2944 364106011785 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 364106011786 non-specific DNA binding site [nucleotide binding]; other site 364106011787 salt bridge; other site 364106011788 sequence-specific DNA binding site [nucleotide binding]; other site 364106011789 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 364106011790 DNA-binding site [nucleotide binding]; DNA binding site 364106011791 RNA-binding motif; other site 364106011792 small toxic polypeptide; Provisional; Region: PRK09759 364106011793 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 364106011794 DALR anticodon binding domain; Region: DALR_1; pfam05746 364106011795 anticodon binding site; other site 364106011796 tRNA binding surface [nucleotide binding]; other site 364106011797 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 364106011798 dimer interface [polypeptide binding]; other site 364106011799 motif 1; other site 364106011800 active site 364106011801 motif 2; other site 364106011802 motif 3; other site 364106011803 YsaB-like lipoprotein; Region: YsaB; pfam13983 364106011804 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 364106011805 Acyltransferase family; Region: Acyl_transf_3; pfam01757 364106011806 hypothetical protein; Provisional; Region: PRK11383 364106011807 yiaA/B two helix domain; Region: YiaAB; pfam05360 364106011808 yiaA/B two helix domain; Region: YiaAB; pfam05360 364106011809 hypothetical protein; Provisional; Region: PRK11403 364106011810 yiaA/B two helix domain; Region: YiaAB; pfam05360 364106011811 xylulokinase; Provisional; Region: PRK15027 364106011812 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 364106011813 N- and C-terminal domain interface [polypeptide binding]; other site 364106011814 active site 364106011815 MgATP binding site [chemical binding]; other site 364106011816 catalytic site [active] 364106011817 metal binding site [ion binding]; metal-binding site 364106011818 xylulose binding site [chemical binding]; other site 364106011819 homodimer interface [polypeptide binding]; other site 364106011820 xylose isomerase; Provisional; Region: PRK05474 364106011821 xylose isomerase; Region: xylose_isom_A; TIGR02630 364106011822 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 364106011823 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 364106011824 putative ligand binding site [chemical binding]; other site 364106011825 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 364106011826 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 364106011827 Walker A/P-loop; other site 364106011828 ATP binding site [chemical binding]; other site 364106011829 Q-loop/lid; other site 364106011830 ABC transporter signature motif; other site 364106011831 Walker B; other site 364106011832 D-loop; other site 364106011833 H-loop/switch region; other site 364106011834 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 364106011835 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 364106011836 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 364106011837 TM-ABC transporter signature motif; other site 364106011838 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 364106011839 putative dimerization interface [polypeptide binding]; other site 364106011840 Transcriptional regulators [Transcription]; Region: PurR; COG1609 364106011841 putative ligand binding site [chemical binding]; other site 364106011842 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106011843 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 364106011844 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106011845 hypothetical protein; Provisional; Region: PRK10356 364106011846 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 364106011847 alpha-amylase; Reviewed; Region: malS; PRK09505 364106011848 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 364106011849 active site 364106011850 catalytic site [active] 364106011851 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 364106011852 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 364106011853 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106011854 homodimer interface [polypeptide binding]; other site 364106011855 catalytic residue [active] 364106011856 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 364106011857 Transcriptional regulator [Transcription]; Region: IclR; COG1414 364106011858 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 364106011859 Bacterial transcriptional regulator; Region: IclR; pfam01614 364106011860 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 364106011861 Domain of unknown function (DUF386); Region: DUF386; pfam04074 364106011862 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 364106011863 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 364106011864 DctM-like transporters; Region: DctM; pfam06808 364106011865 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 364106011866 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 364106011867 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 364106011868 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 364106011869 putative N- and C-terminal domain interface [polypeptide binding]; other site 364106011870 putative active site [active] 364106011871 MgATP binding site [chemical binding]; other site 364106011872 catalytic site [active] 364106011873 metal binding site [ion binding]; metal-binding site 364106011874 putative xylulose binding site [chemical binding]; other site 364106011875 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 364106011876 active site 364106011877 dimer interface [polypeptide binding]; other site 364106011878 magnesium binding site [ion binding]; other site 364106011879 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 364106011880 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 364106011881 AP (apurinic/apyrimidinic) site pocket; other site 364106011882 DNA interaction; other site 364106011883 Metal-binding active site; metal-binding site 364106011884 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 364106011885 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 364106011886 intersubunit interface [polypeptide binding]; other site 364106011887 active site 364106011888 Zn2+ binding site [ion binding]; other site 364106011889 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 364106011890 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 364106011891 NAD(P) binding site [chemical binding]; other site 364106011892 catalytic residues [active] 364106011893 Fic family protein [Function unknown]; Region: COG3177 364106011894 Fic/DOC family; Region: Fic; pfam02661 364106011895 putative alcohol dehydrogenase; Provisional; Region: PRK09860 364106011896 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 364106011897 dimer interface [polypeptide binding]; other site 364106011898 active site 364106011899 metal binding site [ion binding]; metal-binding site 364106011900 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 364106011901 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 364106011902 G1 box; other site 364106011903 putative GEF interaction site [polypeptide binding]; other site 364106011904 GTP/Mg2+ binding site [chemical binding]; other site 364106011905 Switch I region; other site 364106011906 G2 box; other site 364106011907 G3 box; other site 364106011908 Switch II region; other site 364106011909 G4 box; other site 364106011910 G5 box; other site 364106011911 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 364106011912 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 364106011913 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 364106011914 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 364106011915 selenocysteine synthase; Provisional; Region: PRK04311 364106011916 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 364106011917 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 364106011918 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 364106011919 catalytic residue [active] 364106011920 putative glutathione S-transferase; Provisional; Region: PRK10357 364106011921 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 364106011922 putative C-terminal domain interface [polypeptide binding]; other site 364106011923 putative GSH binding site (G-site) [chemical binding]; other site 364106011924 putative dimer interface [polypeptide binding]; other site 364106011925 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 364106011926 dimer interface [polypeptide binding]; other site 364106011927 N-terminal domain interface [polypeptide binding]; other site 364106011928 putative substrate binding pocket (H-site) [chemical binding]; other site 364106011929 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 364106011930 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 364106011931 HlyD family secretion protein; Region: HlyD_3; pfam13437 364106011932 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 364106011933 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 364106011934 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 364106011935 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 364106011936 active site 364106011937 P-loop; other site 364106011938 phosphorylation site [posttranslational modification] 364106011939 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 364106011940 active site 364106011941 phosphorylation site [posttranslational modification] 364106011942 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 364106011943 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 364106011944 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 364106011945 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 364106011946 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 364106011947 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 364106011948 hypothetical protein; Provisional; Region: PRK11020 364106011949 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 364106011950 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 364106011951 trimer interface [polypeptide binding]; other site 364106011952 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 364106011953 trimer interface [polypeptide binding]; other site 364106011954 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 364106011955 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 364106011956 Haemagglutinin; Region: HIM; pfam05662 364106011957 Haemagglutinin; Region: HIM; pfam05662 364106011958 YadA-like C-terminal region; Region: YadA; pfam03895 364106011959 L-lactate permease; Provisional; Region: PRK10420 364106011960 glycolate transporter; Provisional; Region: PRK09695 364106011961 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 364106011962 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 364106011963 DNA-binding site [nucleotide binding]; DNA binding site 364106011964 FCD domain; Region: FCD; pfam07729 364106011965 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 364106011966 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 364106011967 active site 364106011968 substrate binding site [chemical binding]; other site 364106011969 FMN binding site [chemical binding]; other site 364106011970 putative catalytic residues [active] 364106011971 putative rRNA methylase; Provisional; Region: PRK10358 364106011972 serine acetyltransferase; Provisional; Region: cysE; PRK11132 364106011973 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 364106011974 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 364106011975 trimer interface [polypeptide binding]; other site 364106011976 active site 364106011977 substrate binding site [chemical binding]; other site 364106011978 CoA binding site [chemical binding]; other site 364106011979 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 364106011980 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 364106011981 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 364106011982 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 364106011983 SecA binding site; other site 364106011984 Preprotein binding site; other site 364106011985 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 364106011986 GSH binding site [chemical binding]; other site 364106011987 catalytic residues [active] 364106011988 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 364106011989 active site residue [active] 364106011990 phosphoglyceromutase; Provisional; Region: PRK05434 364106011991 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 364106011992 AmiB activator; Provisional; Region: PRK11637 364106011993 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 364106011994 Peptidase family M23; Region: Peptidase_M23; pfam01551 364106011995 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 364106011996 NodB motif; other site 364106011997 putative active site [active] 364106011998 putative catalytic site [active] 364106011999 Zn binding site [ion binding]; other site 364106012000 putative glycosyl transferase; Provisional; Region: PRK10073 364106012001 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 364106012002 active site 364106012003 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 364106012004 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 364106012005 NAD(P) binding site [chemical binding]; other site 364106012006 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 364106012007 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 364106012008 substrate-cofactor binding pocket; other site 364106012009 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106012010 catalytic residue [active] 364106012011 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 364106012012 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 364106012013 NADP binding site [chemical binding]; other site 364106012014 homopentamer interface [polypeptide binding]; other site 364106012015 substrate binding site [chemical binding]; other site 364106012016 active site 364106012017 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 364106012018 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 364106012019 putative active site [active] 364106012020 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 364106012021 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 364106012022 putative active site [active] 364106012023 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 364106012024 O-Antigen ligase; Region: Wzy_C; pfam04932 364106012025 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 364106012026 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 364106012027 active site 364106012028 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 364106012029 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 364106012030 Ligand binding site; other site 364106012031 metal-binding site 364106012032 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 364106012033 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 364106012034 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 364106012035 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 364106012036 Ligand binding site; other site 364106012037 metal-binding site 364106012038 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 364106012039 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 364106012040 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 364106012041 Ligand binding site; other site 364106012042 metal-binding site 364106012043 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 364106012044 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 364106012045 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 364106012046 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 364106012047 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 364106012048 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 364106012049 putative active site [active] 364106012050 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 364106012051 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 364106012052 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 364106012053 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 364106012054 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 364106012055 active site 364106012056 (T/H)XGH motif; other site 364106012057 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 364106012058 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 364106012059 DNA binding site [nucleotide binding] 364106012060 catalytic residue [active] 364106012061 H2TH interface [polypeptide binding]; other site 364106012062 putative catalytic residues [active] 364106012063 turnover-facilitating residue; other site 364106012064 intercalation triad [nucleotide binding]; other site 364106012065 8OG recognition residue [nucleotide binding]; other site 364106012066 putative reading head residues; other site 364106012067 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 364106012068 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 364106012069 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 364106012070 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 364106012071 hypothetical protein; Reviewed; Region: PRK00024 364106012072 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 364106012073 MPN+ (JAMM) motif; other site 364106012074 Zinc-binding site [ion binding]; other site 364106012075 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 364106012076 Flavoprotein; Region: Flavoprotein; pfam02441 364106012077 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 364106012078 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 364106012079 trimer interface [polypeptide binding]; other site 364106012080 active site 364106012081 division inhibitor protein; Provisional; Region: slmA; PRK09480 364106012082 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 364106012083 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 364106012084 active site 364106012085 ribonuclease PH; Reviewed; Region: rph; PRK00173 364106012086 Ribonuclease PH; Region: RNase_PH_bact; cd11362 364106012087 hexamer interface [polypeptide binding]; other site 364106012088 active site 364106012089 hypothetical protein; Provisional; Region: PRK11820 364106012090 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 364106012091 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 364106012092 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 364106012093 BRO family, N-terminal domain; Region: Bro-N; pfam02498 364106012094 Predicted membrane protein [Function unknown]; Region: COG2860 364106012095 UPF0126 domain; Region: UPF0126; pfam03458 364106012096 UPF0126 domain; Region: UPF0126; pfam03458 364106012097 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 364106012098 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 364106012099 nucleotide binding pocket [chemical binding]; other site 364106012100 K-X-D-G motif; other site 364106012101 catalytic site [active] 364106012102 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 364106012103 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 364106012104 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 364106012105 catalytic site [active] 364106012106 G-X2-G-X-G-K; other site 364106012107 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 364106012108 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 364106012109 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 364106012110 Zn2+ binding site [ion binding]; other site 364106012111 Mg2+ binding site [ion binding]; other site 364106012112 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 364106012113 synthetase active site [active] 364106012114 NTP binding site [chemical binding]; other site 364106012115 metal binding site [ion binding]; metal-binding site 364106012116 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 364106012117 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 364106012118 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 364106012119 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 364106012120 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 364106012121 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 364106012122 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 364106012123 generic binding surface II; other site 364106012124 ssDNA binding site; other site 364106012125 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 364106012126 ATP binding site [chemical binding]; other site 364106012127 putative Mg++ binding site [ion binding]; other site 364106012128 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 364106012129 nucleotide binding region [chemical binding]; other site 364106012130 ATP-binding site [chemical binding]; other site 364106012131 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 364106012132 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 364106012133 AsmA family; Region: AsmA; pfam05170 364106012134 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 364106012135 Protein of unknown function (DUF1498); Region: DUF1498; pfam07385 364106012136 fructokinase; Reviewed; Region: PRK09557 364106012137 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 364106012138 nucleotide binding site [chemical binding]; other site 364106012139 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 364106012140 intersubunit interface [polypeptide binding]; other site 364106012141 active site 364106012142 zinc binding site [ion binding]; other site 364106012143 Na+ binding site [ion binding]; other site 364106012144 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 364106012145 intersubunit interface [polypeptide binding]; other site 364106012146 active site 364106012147 zinc binding site [ion binding]; other site 364106012148 Na+ binding site [ion binding]; other site 364106012149 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 364106012150 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 364106012151 active site 364106012152 P-loop; other site 364106012153 phosphorylation site [posttranslational modification] 364106012154 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 364106012155 active site 364106012156 phosphorylation site [posttranslational modification] 364106012157 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 364106012158 HTH domain; Region: HTH_11; pfam08279 364106012159 Mga helix-turn-helix domain; Region: Mga; pfam05043 364106012160 PRD domain; Region: PRD; pfam00874 364106012161 PRD domain; Region: PRD; pfam00874 364106012162 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 364106012163 active site 364106012164 P-loop; other site 364106012165 phosphorylation site [posttranslational modification] 364106012166 putative alpha-glucosidase; Provisional; Region: PRK10658 364106012167 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 364106012168 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 364106012169 active site 364106012170 homotrimer interface [polypeptide binding]; other site 364106012171 catalytic site [active] 364106012172 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 364106012173 putative transporter; Provisional; Region: PRK11462 364106012174 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 364106012175 Virulence protein [General function prediction only]; Region: COG3943 364106012176 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 364106012177 Virulence protein [General function prediction only]; Region: COG3943 364106012178 EamA-like transporter family; Region: EamA; pfam00892 364106012179 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 364106012180 EamA-like transporter family; Region: EamA; pfam00892 364106012181 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 364106012182 lipoprotein, YaeC family; Region: TIGR00363 364106012183 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 364106012184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106012185 putative substrate translocation pore; other site 364106012186 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 364106012187 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 364106012188 cryptic adenine deaminase; Provisional; Region: PRK10027 364106012189 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 364106012190 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 364106012191 active site 364106012192 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 364106012193 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 364106012194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106012195 putative substrate translocation pore; other site 364106012196 regulatory protein UhpC; Provisional; Region: PRK11663 364106012197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106012198 putative substrate translocation pore; other site 364106012199 sensory histidine kinase UhpB; Provisional; Region: PRK11644 364106012200 MASE1; Region: MASE1; pfam05231 364106012201 Histidine kinase; Region: HisKA_3; pfam07730 364106012202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106012203 ATP binding site [chemical binding]; other site 364106012204 Mg2+ binding site [ion binding]; other site 364106012205 G-X-G motif; other site 364106012206 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 364106012207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106012208 active site 364106012209 phosphorylation site [posttranslational modification] 364106012210 intermolecular recognition site; other site 364106012211 dimerization interface [polypeptide binding]; other site 364106012212 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 364106012213 DNA binding residues [nucleotide binding] 364106012214 dimerization interface [polypeptide binding]; other site 364106012215 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 364106012216 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 364106012217 putative valine binding site [chemical binding]; other site 364106012218 dimer interface [polypeptide binding]; other site 364106012219 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 364106012220 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 364106012221 PYR/PP interface [polypeptide binding]; other site 364106012222 dimer interface [polypeptide binding]; other site 364106012223 TPP binding site [chemical binding]; other site 364106012224 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 364106012225 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 364106012226 TPP-binding site [chemical binding]; other site 364106012227 dimer interface [polypeptide binding]; other site 364106012228 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 364106012229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106012230 putative substrate translocation pore; other site 364106012231 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 364106012232 Domain of unknown function (DUF202); Region: DUF202; pfam02656 364106012233 Predicted membrane protein [Function unknown]; Region: COG2149 364106012234 putative transporter; Provisional; Region: PRK10484 364106012235 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 364106012236 Na binding site [ion binding]; other site 364106012237 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 364106012238 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106012239 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 364106012240 putative transporter; Validated; Region: PRK03818 364106012241 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 364106012242 TrkA-C domain; Region: TrkA_C; pfam02080 364106012243 TrkA-C domain; Region: TrkA_C; pfam02080 364106012244 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 364106012245 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 364106012246 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 364106012247 putative dimer interface [polypeptide binding]; other site 364106012248 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 364106012249 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 364106012250 putative dimer interface [polypeptide binding]; other site 364106012251 hypothetical protein; Provisional; Region: PRK11616 364106012252 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 364106012253 putative oxidoreductase; Provisional; Region: PRK11445 364106012254 hypothetical protein; Provisional; Region: PRK07236 364106012255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106012256 D-galactonate transporter; Region: 2A0114; TIGR00893 364106012257 putative substrate translocation pore; other site 364106012258 galactonate dehydratase; Provisional; Region: PRK14017 364106012259 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 364106012260 putative active site pocket [active] 364106012261 putative metal binding site [ion binding]; other site 364106012262 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 364106012263 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 364106012264 active site 364106012265 intersubunit interface [polypeptide binding]; other site 364106012266 catalytic residue [active] 364106012267 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 364106012268 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 364106012269 Transcriptional regulators [Transcription]; Region: FadR; COG2186 364106012270 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 364106012271 DNA-binding site [nucleotide binding]; DNA binding site 364106012272 FCD domain; Region: FCD; pfam07729 364106012273 sugar phosphate phosphatase; Provisional; Region: PRK10513 364106012274 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 364106012275 active site 364106012276 motif I; other site 364106012277 motif II; other site 364106012278 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 364106012279 hypothetical protein; Provisional; Region: PRK11426 364106012280 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 364106012281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106012282 Mg2+ binding site [ion binding]; other site 364106012283 G-X-G motif; other site 364106012284 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 364106012285 anchoring element; other site 364106012286 dimer interface [polypeptide binding]; other site 364106012287 ATP binding site [chemical binding]; other site 364106012288 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 364106012289 active site 364106012290 putative metal-binding site [ion binding]; other site 364106012291 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 364106012292 recF protein; Region: recf; TIGR00611 364106012293 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 364106012294 Walker A/P-loop; other site 364106012295 ATP binding site [chemical binding]; other site 364106012296 Q-loop/lid; other site 364106012297 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 364106012298 ABC transporter signature motif; other site 364106012299 Walker B; other site 364106012300 D-loop; other site 364106012301 H-loop/switch region; other site 364106012302 DNA polymerase III subunit beta; Validated; Region: PRK05643 364106012303 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 364106012304 putative DNA binding surface [nucleotide binding]; other site 364106012305 dimer interface [polypeptide binding]; other site 364106012306 beta-clamp/clamp loader binding surface; other site 364106012307 beta-clamp/translesion DNA polymerase binding surface; other site 364106012308 DnaA N-terminal domain; Region: DnaA_N; pfam11638 364106012309 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 364106012310 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106012311 Walker A motif; other site 364106012312 ATP binding site [chemical binding]; other site 364106012313 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 364106012314 Walker B motif; other site 364106012315 arginine finger; other site 364106012316 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 364106012317 DnaA box-binding interface [nucleotide binding]; other site 364106012318 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 364106012319 ribonuclease P; Reviewed; Region: rnpA; PRK01732 364106012320 hypothetical protein; Validated; Region: PRK00041 364106012321 membrane protein insertase; Provisional; Region: PRK01318 364106012322 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 364106012323 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 364106012324 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 364106012325 trmE is a tRNA modification GTPase; Region: trmE; cd04164 364106012326 G1 box; other site 364106012327 GTP/Mg2+ binding site [chemical binding]; other site 364106012328 Switch I region; other site 364106012329 G2 box; other site 364106012330 Switch II region; other site 364106012331 G3 box; other site 364106012332 G4 box; other site 364106012333 G5 box; other site 364106012334 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 364106012335 Tryptophanese operon leader peptide; Region: Tna_leader; pfam08053 364106012336 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 364106012337 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 364106012338 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 364106012339 catalytic residue [active] 364106012340 tryptophan permease TnaB; Provisional; Region: PRK09664 364106012341 aromatic amino acid transport protein; Region: araaP; TIGR00837 364106012342 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 364106012343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106012344 putative substrate translocation pore; other site 364106012345 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 364106012346 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106012347 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 364106012348 substrate binding pocket [chemical binding]; other site 364106012349 dimerization interface [polypeptide binding]; other site 364106012350 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 364106012351 Predicted flavoprotein [General function prediction only]; Region: COG0431 364106012352 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 364106012353 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 364106012354 putative inner membrane protein; Provisional; Region: PRK09823 364106012355 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 364106012356 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 364106012357 active site 364106012358 trimer interface [polypeptide binding]; other site 364106012359 allosteric site; other site 364106012360 active site lid [active] 364106012361 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 364106012362 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 364106012363 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 364106012364 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 364106012365 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 364106012366 trimer interface; other site 364106012367 sugar binding site [chemical binding]; other site 364106012368 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 364106012369 beta-galactosidase; Region: BGL; TIGR03356 364106012370 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 364106012371 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 364106012372 active site turn [active] 364106012373 phosphorylation site [posttranslational modification] 364106012374 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 364106012375 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 364106012376 HPr interaction site; other site 364106012377 glycerol kinase (GK) interaction site [polypeptide binding]; other site 364106012378 active site 364106012379 phosphorylation site [posttranslational modification] 364106012380 transcriptional antiterminator BglG; Provisional; Region: PRK09772 364106012381 CAT RNA binding domain; Region: CAT_RBD; pfam03123 364106012382 PRD domain; Region: PRD; pfam00874 364106012383 PRD domain; Region: PRD; pfam00874 364106012384 transcriptional regulator PhoU; Provisional; Region: PRK11115 364106012385 PhoU domain; Region: PhoU; pfam01895 364106012386 PhoU domain; Region: PhoU; pfam01895 364106012387 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 364106012388 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 364106012389 Walker A/P-loop; other site 364106012390 ATP binding site [chemical binding]; other site 364106012391 Q-loop/lid; other site 364106012392 ABC transporter signature motif; other site 364106012393 Walker B; other site 364106012394 D-loop; other site 364106012395 H-loop/switch region; other site 364106012396 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 364106012397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106012398 dimer interface [polypeptide binding]; other site 364106012399 conserved gate region; other site 364106012400 putative PBP binding loops; other site 364106012401 ABC-ATPase subunit interface; other site 364106012402 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 364106012403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106012404 dimer interface [polypeptide binding]; other site 364106012405 conserved gate region; other site 364106012406 putative PBP binding loops; other site 364106012407 ABC-ATPase subunit interface; other site 364106012408 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 364106012409 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 364106012410 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 364106012411 glutaminase active site [active] 364106012412 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 364106012413 dimer interface [polypeptide binding]; other site 364106012414 active site 364106012415 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 364106012416 dimer interface [polypeptide binding]; other site 364106012417 active site 364106012418 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 364106012419 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 364106012420 Substrate binding site; other site 364106012421 Mg++ binding site; other site 364106012422 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 364106012423 active site 364106012424 substrate binding site [chemical binding]; other site 364106012425 CoA binding site [chemical binding]; other site 364106012426 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 364106012427 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 364106012428 gamma subunit interface [polypeptide binding]; other site 364106012429 epsilon subunit interface [polypeptide binding]; other site 364106012430 LBP interface [polypeptide binding]; other site 364106012431 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 364106012432 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 364106012433 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 364106012434 alpha subunit interaction interface [polypeptide binding]; other site 364106012435 Walker A motif; other site 364106012436 ATP binding site [chemical binding]; other site 364106012437 Walker B motif; other site 364106012438 inhibitor binding site; inhibition site 364106012439 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 364106012440 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 364106012441 core domain interface [polypeptide binding]; other site 364106012442 delta subunit interface [polypeptide binding]; other site 364106012443 epsilon subunit interface [polypeptide binding]; other site 364106012444 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 364106012445 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 364106012446 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 364106012447 beta subunit interaction interface [polypeptide binding]; other site 364106012448 Walker A motif; other site 364106012449 ATP binding site [chemical binding]; other site 364106012450 Walker B motif; other site 364106012451 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 364106012452 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 364106012453 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 364106012454 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 364106012455 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 364106012456 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 364106012457 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 364106012458 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 364106012459 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 364106012460 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 364106012461 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106012462 S-adenosylmethionine binding site [chemical binding]; other site 364106012463 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 364106012464 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 364106012465 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 364106012466 FMN-binding protein MioC; Provisional; Region: PRK09004 364106012467 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 364106012468 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 364106012469 putative DNA binding site [nucleotide binding]; other site 364106012470 putative Zn2+ binding site [ion binding]; other site 364106012471 AsnC family; Region: AsnC_trans_reg; pfam01037 364106012472 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 364106012473 dimer interface [polypeptide binding]; other site 364106012474 active site 364106012475 hypothetical protein; Provisional; Region: yieM; PRK10997 364106012476 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 364106012477 metal ion-dependent adhesion site (MIDAS); other site 364106012478 regulatory ATPase RavA; Provisional; Region: PRK13531 364106012479 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106012480 Walker A motif; other site 364106012481 ATP binding site [chemical binding]; other site 364106012482 Walker B motif; other site 364106012483 arginine finger; other site 364106012484 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 364106012485 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 364106012486 potassium uptake protein; Region: kup; TIGR00794 364106012487 D-ribose pyranase; Provisional; Region: PRK11797 364106012488 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 364106012489 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 364106012490 Walker A/P-loop; other site 364106012491 ATP binding site [chemical binding]; other site 364106012492 Q-loop/lid; other site 364106012493 ABC transporter signature motif; other site 364106012494 Walker B; other site 364106012495 D-loop; other site 364106012496 H-loop/switch region; other site 364106012497 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 364106012498 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 364106012499 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 364106012500 TM-ABC transporter signature motif; other site 364106012501 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 364106012502 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 364106012503 ligand binding site [chemical binding]; other site 364106012504 dimerization interface [polypeptide binding]; other site 364106012505 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 364106012506 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 364106012507 substrate binding site [chemical binding]; other site 364106012508 dimer interface [polypeptide binding]; other site 364106012509 ATP binding site [chemical binding]; other site 364106012510 transcriptional repressor RbsR; Provisional; Region: PRK10423 364106012511 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 364106012512 DNA binding site [nucleotide binding] 364106012513 domain linker motif; other site 364106012514 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 364106012515 dimerization interface [polypeptide binding]; other site 364106012516 ligand binding site [chemical binding]; other site 364106012517 putative transporter; Provisional; Region: PRK10504 364106012518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106012519 putative substrate translocation pore; other site 364106012520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106012521 Transcriptional regulators [Transcription]; Region: FadR; COG2186 364106012522 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 364106012523 DNA-binding site [nucleotide binding]; DNA binding site 364106012524 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 364106012525 transcriptional regulator HdfR; Provisional; Region: PRK03601 364106012526 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106012527 LysR substrate binding domain; Region: LysR_substrate; pfam03466 364106012528 dimerization interface [polypeptide binding]; other site 364106012529 hypothetical protein; Provisional; Region: PRK11027 364106012530 putative ATP-dependent protease; Provisional; Region: PRK09862 364106012531 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 364106012532 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106012533 Walker A motif; other site 364106012534 ATP binding site [chemical binding]; other site 364106012535 Walker B motif; other site 364106012536 arginine finger; other site 364106012537 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 364106012538 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 364106012539 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 364106012540 PYR/PP interface [polypeptide binding]; other site 364106012541 dimer interface [polypeptide binding]; other site 364106012542 TPP binding site [chemical binding]; other site 364106012543 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 364106012544 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 364106012545 TPP-binding site [chemical binding]; other site 364106012546 dimer interface [polypeptide binding]; other site 364106012547 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 364106012548 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 364106012549 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 364106012550 homodimer interface [polypeptide binding]; other site 364106012551 substrate-cofactor binding pocket; other site 364106012552 catalytic residue [active] 364106012553 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 364106012554 threonine dehydratase; Reviewed; Region: PRK09224 364106012555 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 364106012556 tetramer interface [polypeptide binding]; other site 364106012557 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106012558 catalytic residue [active] 364106012559 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 364106012560 putative Ile/Val binding site [chemical binding]; other site 364106012561 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 364106012562 putative Ile/Val binding site [chemical binding]; other site 364106012563 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106012564 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 364106012565 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 364106012566 putative dimerization interface [polypeptide binding]; other site 364106012567 ketol-acid reductoisomerase; Validated; Region: PRK05225 364106012568 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 364106012569 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 364106012570 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 364106012571 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 364106012572 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 364106012573 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 364106012574 Part of AAA domain; Region: AAA_19; pfam13245 364106012575 Family description; Region: UvrD_C_2; pfam13538 364106012576 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 364106012577 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 364106012578 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 364106012579 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 364106012580 ATP binding site [chemical binding]; other site 364106012581 Mg++ binding site [ion binding]; other site 364106012582 motif III; other site 364106012583 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 364106012584 nucleotide binding region [chemical binding]; other site 364106012585 ATP-binding site [chemical binding]; other site 364106012586 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 364106012587 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 364106012588 catalytic residues [active] 364106012589 putative rho operon leader peptide; Provisional; Region: PRK09979 364106012590 transcription termination factor Rho; Provisional; Region: rho; PRK09376 364106012591 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 364106012592 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 364106012593 RNA binding site [nucleotide binding]; other site 364106012594 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 364106012595 multimer interface [polypeptide binding]; other site 364106012596 Walker A motif; other site 364106012597 ATP binding site [chemical binding]; other site 364106012598 Walker B motif; other site 364106012599 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 364106012600 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 364106012601 Mg++ binding site [ion binding]; other site 364106012602 putative catalytic motif [active] 364106012603 substrate binding site [chemical binding]; other site 364106012604 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 364106012605 Chain length determinant protein; Region: Wzz; pfam02706 364106012606 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 364106012607 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 364106012608 active site 364106012609 homodimer interface [polypeptide binding]; other site 364106012610 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 364106012611 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 364106012612 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 364106012613 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 364106012614 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 364106012615 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 364106012616 NAD binding site [chemical binding]; other site 364106012617 substrate binding site [chemical binding]; other site 364106012618 homodimer interface [polypeptide binding]; other site 364106012619 active site 364106012620 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 364106012621 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 364106012622 substrate binding site; other site 364106012623 tetramer interface; other site 364106012624 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 364106012625 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 364106012626 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 364106012627 inhibitor-cofactor binding pocket; inhibition site 364106012628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106012629 catalytic residue [active] 364106012630 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 364106012631 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 364106012632 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 364106012633 putative common antigen polymerase; Provisional; Region: PRK02975 364106012634 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 364106012635 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 364106012636 putative transport protein YifK; Provisional; Region: PRK10746 364106012637 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 364106012638 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 364106012639 FeS/SAM binding site; other site 364106012640 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 364106012641 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 364106012642 Sulfatase; Region: Sulfatase; pfam00884 364106012643 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 364106012644 HemY protein N-terminus; Region: HemY_N; pfam07219 364106012645 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 364106012646 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 364106012647 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 364106012648 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 364106012649 active site 364106012650 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 364106012651 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 364106012652 domain interfaces; other site 364106012653 active site 364106012654 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 364106012655 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 364106012656 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 364106012657 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 364106012658 putative iron binding site [ion binding]; other site 364106012659 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 364106012660 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 364106012661 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 364106012662 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 364106012663 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 364106012664 hypothetical protein; Provisional; Region: PRK10963 364106012665 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 364106012666 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 364106012667 active site 364106012668 DNA binding site [nucleotide binding] 364106012669 Int/Topo IB signature motif; other site 364106012670 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 364106012671 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 364106012672 motif II; other site 364106012673 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 364106012674 Part of AAA domain; Region: AAA_19; pfam13245 364106012675 Family description; Region: UvrD_C_2; pfam13538 364106012676 Uncharacterized conserved protein [Function unknown]; Region: COG1912 364106012677 Predicted periplasmic protein [Function unknown]; Region: COG3698 364106012678 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 364106012679 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 364106012680 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 364106012681 Cl binding site [ion binding]; other site 364106012682 oligomer interface [polypeptide binding]; other site 364106012683 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 364106012684 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 364106012685 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 364106012686 EamA-like transporter family; Region: EamA; cl17759 364106012687 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 364106012688 CoenzymeA binding site [chemical binding]; other site 364106012689 subunit interaction site [polypeptide binding]; other site 364106012690 PHB binding site; other site 364106012691 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 364106012692 dimerization interface [polypeptide binding]; other site 364106012693 substrate binding site [chemical binding]; other site 364106012694 active site 364106012695 calcium binding site [ion binding]; other site 364106012696 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 364106012697 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 364106012698 ATP binding site [chemical binding]; other site 364106012699 putative Mg++ binding site [ion binding]; other site 364106012700 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 364106012701 nucleotide binding region [chemical binding]; other site 364106012702 ATP-binding site [chemical binding]; other site 364106012703 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 364106012704 Helicase and RNase D C-terminal; Region: HRDC; smart00341 364106012705 threonine efflux system; Provisional; Region: PRK10229 364106012706 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 364106012707 lysophospholipase L2; Provisional; Region: PRK10749 364106012708 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 364106012709 putative hydrolase; Provisional; Region: PRK10976 364106012710 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 364106012711 active site 364106012712 motif I; other site 364106012713 motif II; other site 364106012714 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 364106012715 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 364106012716 EamA-like transporter family; Region: EamA; pfam00892 364106012717 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 364106012718 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106012719 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 364106012720 putative dimerization interface [polypeptide binding]; other site 364106012721 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 364106012722 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 364106012723 THF binding site; other site 364106012724 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 364106012725 substrate binding site [chemical binding]; other site 364106012726 THF binding site; other site 364106012727 zinc-binding site [ion binding]; other site 364106012728 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 364106012729 tetramer interface [polypeptide binding]; other site 364106012730 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 364106012731 active site 364106012732 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 364106012733 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 364106012734 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 364106012735 active site turn [active] 364106012736 phosphorylation site [posttranslational modification] 364106012737 transketolase; Reviewed; Region: PRK12753 364106012738 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 364106012739 TPP-binding site [chemical binding]; other site 364106012740 dimer interface [polypeptide binding]; other site 364106012741 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 364106012742 PYR/PP interface [polypeptide binding]; other site 364106012743 dimer interface [polypeptide binding]; other site 364106012744 TPP binding site [chemical binding]; other site 364106012745 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 364106012746 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 364106012747 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 364106012748 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 364106012749 putative active site [active] 364106012750 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 364106012751 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106012752 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 364106012753 dimerization interface [polypeptide binding]; other site 364106012754 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 364106012755 Na binding site [ion binding]; other site 364106012756 allophanate hydrolase; Provisional; Region: PRK08186 364106012757 carbamate kinase; Reviewed; Region: PRK12686 364106012758 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 364106012759 putative substrate binding site [chemical binding]; other site 364106012760 nucleotide binding site [chemical binding]; other site 364106012761 nucleotide binding site [chemical binding]; other site 364106012762 homodimer interface [polypeptide binding]; other site 364106012763 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 364106012764 CoA binding domain; Region: CoA_binding; pfam02629 364106012765 CoA-ligase; Region: Ligase_CoA; pfam00549 364106012766 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 364106012767 Isochorismatase family; Region: Isochorismatase; pfam00857 364106012768 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 364106012769 catalytic triad [active] 364106012770 conserved cis-peptide bond; other site 364106012771 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 364106012772 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 364106012773 uridine phosphorylase; Provisional; Region: PRK11178 364106012774 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 364106012775 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 364106012776 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 364106012777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 364106012778 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 364106012779 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 364106012780 active site 364106012781 intersubunit interface [polypeptide binding]; other site 364106012782 catalytic residue [active] 364106012783 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 364106012784 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 364106012785 Transcriptional regulator [Transcription]; Region: IclR; COG1414 364106012786 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 364106012787 Bacterial transcriptional regulator; Region: IclR; pfam01614 364106012788 DNA recombination protein RmuC; Provisional; Region: PRK10361 364106012789 RmuC family; Region: RmuC; pfam02646 364106012790 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 364106012791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106012792 S-adenosylmethionine binding site [chemical binding]; other site 364106012793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 364106012794 SCP-2 sterol transfer family; Region: SCP2; pfam02036 364106012795 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 364106012796 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 364106012797 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 364106012798 sec-independent translocase; Provisional; Region: PRK01770 364106012799 sec-independent translocase; Provisional; Region: tatB; PRK00404 364106012800 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 364106012801 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 364106012802 active site 364106012803 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 364106012804 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 364106012805 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 364106012806 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 364106012807 FMN reductase; Validated; Region: fre; PRK08051 364106012808 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 364106012809 FAD binding pocket [chemical binding]; other site 364106012810 FAD binding motif [chemical binding]; other site 364106012811 phosphate binding motif [ion binding]; other site 364106012812 beta-alpha-beta structure motif; other site 364106012813 NAD binding pocket [chemical binding]; other site 364106012814 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 364106012815 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 364106012816 dimer interface [polypeptide binding]; other site 364106012817 active site 364106012818 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 364106012819 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 364106012820 substrate binding site [chemical binding]; other site 364106012821 oxyanion hole (OAH) forming residues; other site 364106012822 trimer interface [polypeptide binding]; other site 364106012823 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 364106012824 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 364106012825 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 364106012826 proline dipeptidase; Provisional; Region: PRK13607 364106012827 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 364106012828 active site 364106012829 hypothetical protein; Provisional; Region: PRK11568 364106012830 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 364106012831 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 364106012832 potassium transporter; Provisional; Region: PRK10750 364106012833 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 364106012834 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 364106012835 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 364106012836 Walker A motif; other site 364106012837 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 364106012838 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 364106012839 GTP binding site; other site 364106012840 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 364106012841 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 364106012842 serine/threonine protein kinase; Provisional; Region: PRK11768 364106012843 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 364106012844 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 364106012845 catalytic residues [active] 364106012846 hinge region; other site 364106012847 alpha helical domain; other site 364106012848 hypothetical protein; Provisional; Region: PRK11367 364106012849 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 364106012850 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 364106012851 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 364106012852 putative acyl-acceptor binding pocket; other site 364106012853 DNA polymerase I; Provisional; Region: PRK05755 364106012854 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 364106012855 active site 364106012856 metal binding site 1 [ion binding]; metal-binding site 364106012857 putative 5' ssDNA interaction site; other site 364106012858 metal binding site 3; metal-binding site 364106012859 metal binding site 2 [ion binding]; metal-binding site 364106012860 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 364106012861 putative DNA binding site [nucleotide binding]; other site 364106012862 putative metal binding site [ion binding]; other site 364106012863 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 364106012864 active site 364106012865 catalytic site [active] 364106012866 substrate binding site [chemical binding]; other site 364106012867 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 364106012868 active site 364106012869 DNA binding site [nucleotide binding] 364106012870 catalytic site [active] 364106012871 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 364106012872 G1 box; other site 364106012873 GTP/Mg2+ binding site [chemical binding]; other site 364106012874 Switch I region; other site 364106012875 G2 box; other site 364106012876 G3 box; other site 364106012877 Switch II region; other site 364106012878 G4 box; other site 364106012879 G5 box; other site 364106012880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 364106012881 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 364106012882 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 364106012883 FeS/SAM binding site; other site 364106012884 HemN C-terminal domain; Region: HemN_C; pfam06969 364106012885 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 364106012886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106012887 active site 364106012888 phosphorylation site [posttranslational modification] 364106012889 intermolecular recognition site; other site 364106012890 dimerization interface [polypeptide binding]; other site 364106012891 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106012892 Walker A motif; other site 364106012893 ATP binding site [chemical binding]; other site 364106012894 Walker B motif; other site 364106012895 arginine finger; other site 364106012896 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 364106012897 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 364106012898 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 364106012899 putative active site [active] 364106012900 heme pocket [chemical binding]; other site 364106012901 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 364106012902 dimer interface [polypeptide binding]; other site 364106012903 phosphorylation site [posttranslational modification] 364106012904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106012905 ATP binding site [chemical binding]; other site 364106012906 Mg2+ binding site [ion binding]; other site 364106012907 G-X-G motif; other site 364106012908 glutamine synthetase; Provisional; Region: glnA; PRK09469 364106012909 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 364106012910 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 364106012911 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 364106012912 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 364106012913 G1 box; other site 364106012914 putative GEF interaction site [polypeptide binding]; other site 364106012915 GTP/Mg2+ binding site [chemical binding]; other site 364106012916 Switch I region; other site 364106012917 G2 box; other site 364106012918 G3 box; other site 364106012919 Switch II region; other site 364106012920 G4 box; other site 364106012921 G5 box; other site 364106012922 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 364106012923 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 364106012924 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 364106012925 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 364106012926 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 364106012927 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 364106012928 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 364106012929 substrate binding site [chemical binding]; other site 364106012930 ATP binding site [chemical binding]; other site 364106012931 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 364106012932 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 364106012933 Class I aldolases; Region: Aldolase_Class_I; cl17187 364106012934 catalytic residue [active] 364106012935 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 364106012936 putative oxidoreductase; Provisional; Region: PRK10083 364106012937 NAD(P) binding site [chemical binding]; other site 364106012938 benzoate transport; Region: 2A0115; TIGR00895 364106012939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106012940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106012941 shikimate transporter; Provisional; Region: PRK09952 364106012942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106012943 putative substrate translocation pore; other site 364106012944 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 364106012945 active site 364106012946 catalytic residues [active] 364106012947 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 364106012948 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 364106012949 motif II; other site 364106012950 hypothetical protein; Reviewed; Region: PRK01637 364106012951 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 364106012952 putative active site [active] 364106012953 dimerization interface [polypeptide binding]; other site 364106012954 putative tRNAtyr binding site [nucleotide binding]; other site 364106012955 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 364106012956 Coenzyme A binding pocket [chemical binding]; other site 364106012957 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 364106012958 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 364106012959 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 364106012960 substrate binding pocket [chemical binding]; other site 364106012961 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 364106012962 non-specific DNA binding site [nucleotide binding]; other site 364106012963 salt bridge; other site 364106012964 sequence-specific DNA binding site [nucleotide binding]; other site 364106012965 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 364106012966 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 364106012967 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 364106012968 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 364106012969 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 364106012970 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 364106012971 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 364106012972 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 364106012973 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 364106012974 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 364106012975 intersubunit interface [polypeptide binding]; other site 364106012976 active site 364106012977 Zn2+ binding site [ion binding]; other site 364106012978 L-rhamnose isomerase; Provisional; Region: PRK01076 364106012979 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 364106012980 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 364106012981 N- and C-terminal domain interface [polypeptide binding]; other site 364106012982 active site 364106012983 putative catalytic site [active] 364106012984 metal binding site [ion binding]; metal-binding site 364106012985 ATP binding site [chemical binding]; other site 364106012986 rhamnulokinase; Provisional; Region: rhaB; PRK10640 364106012987 carbohydrate binding site [chemical binding]; other site 364106012988 transcriptional activator RhaS; Provisional; Region: PRK13503 364106012989 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 364106012990 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106012991 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106012992 transcriptional activator RhaR; Provisional; Region: PRK13500 364106012993 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 364106012994 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106012995 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106012996 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 364106012997 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 364106012998 superoxide dismutase; Provisional; Region: PRK10925 364106012999 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 364106013000 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 364106013001 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 364106013002 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 364106013003 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 364106013004 MOSC domain; Region: MOSC; pfam03473 364106013005 3-alpha domain; Region: 3-alpha; pfam03475 364106013006 two-component sensor protein; Provisional; Region: cpxA; PRK09470 364106013007 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 364106013008 dimerization interface [polypeptide binding]; other site 364106013009 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 364106013010 dimer interface [polypeptide binding]; other site 364106013011 phosphorylation site [posttranslational modification] 364106013012 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106013013 ATP binding site [chemical binding]; other site 364106013014 Mg2+ binding site [ion binding]; other site 364106013015 G-X-G motif; other site 364106013016 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 364106013017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106013018 active site 364106013019 intermolecular recognition site; other site 364106013020 dimerization interface [polypeptide binding]; other site 364106013021 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 364106013022 DNA binding site [nucleotide binding] 364106013023 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 364106013024 dimer interface [polypeptide binding]; other site 364106013025 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 364106013026 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 364106013027 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 364106013028 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 364106013029 active site 364106013030 ADP/pyrophosphate binding site [chemical binding]; other site 364106013031 dimerization interface [polypeptide binding]; other site 364106013032 allosteric effector site; other site 364106013033 fructose-1,6-bisphosphate binding site; other site 364106013034 sulfate transporter subunit; Provisional; Region: PRK10752 364106013035 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 364106013036 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 364106013037 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 364106013038 triosephosphate isomerase; Provisional; Region: PRK14567 364106013039 substrate binding site [chemical binding]; other site 364106013040 dimer interface [polypeptide binding]; other site 364106013041 catalytic triad [active] 364106013042 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 364106013043 Predicted membrane protein [Function unknown]; Region: COG3152 364106013044 hypothetical protein; Provisional; Region: PRK09981 364106013045 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 364106013046 Ligand Binding Site [chemical binding]; other site 364106013047 ferredoxin-NADP reductase; Provisional; Region: PRK10926 364106013048 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 364106013049 FAD binding pocket [chemical binding]; other site 364106013050 FAD binding motif [chemical binding]; other site 364106013051 phosphate binding motif [ion binding]; other site 364106013052 beta-alpha-beta structure motif; other site 364106013053 NAD binding pocket [chemical binding]; other site 364106013054 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 364106013055 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 364106013056 putative active site [active] 364106013057 glycerol kinase; Provisional; Region: glpK; PRK00047 364106013058 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 364106013059 N- and C-terminal domain interface [polypeptide binding]; other site 364106013060 active site 364106013061 MgATP binding site [chemical binding]; other site 364106013062 catalytic site [active] 364106013063 metal binding site [ion binding]; metal-binding site 364106013064 glycerol binding site [chemical binding]; other site 364106013065 homotetramer interface [polypeptide binding]; other site 364106013066 homodimer interface [polypeptide binding]; other site 364106013067 FBP binding site [chemical binding]; other site 364106013068 protein IIAGlc interface [polypeptide binding]; other site 364106013069 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 364106013070 amphipathic channel; other site 364106013071 Asn-Pro-Ala signature motifs; other site 364106013072 septal ring assembly protein ZapB; Provisional; Region: PRK15422 364106013073 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 364106013074 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 364106013075 UbiA prenyltransferase family; Region: UbiA; pfam01040 364106013076 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 364106013077 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106013078 Walker A motif; other site 364106013079 ATP binding site [chemical binding]; other site 364106013080 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 364106013081 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 364106013082 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 364106013083 active site 364106013084 HslU subunit interaction site [polypeptide binding]; other site 364106013085 essential cell division protein FtsN; Provisional; Region: PRK10927 364106013086 cell division protein FtsN; Provisional; Region: PRK12757 364106013087 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 364106013088 DNA binding site [nucleotide binding] 364106013089 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 364106013090 domain linker motif; other site 364106013091 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 364106013092 dimerization interface [polypeptide binding]; other site 364106013093 ligand binding site [chemical binding]; other site 364106013094 primosome assembly protein PriA; Validated; Region: PRK05580 364106013095 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 364106013096 ATP binding site [chemical binding]; other site 364106013097 putative Mg++ binding site [ion binding]; other site 364106013098 helicase superfamily c-terminal domain; Region: HELICc; smart00490 364106013099 ATP-binding site [chemical binding]; other site 364106013100 hypothetical protein; Provisional; Region: PRK10030 364106013101 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 364106013102 dimerization interface [polypeptide binding]; other site 364106013103 DNA binding site [nucleotide binding] 364106013104 corepressor binding sites; other site 364106013105 cystathionine gamma-synthase; Provisional; Region: PRK08045 364106013106 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 364106013107 homodimer interface [polypeptide binding]; other site 364106013108 substrate-cofactor binding pocket; other site 364106013109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106013110 catalytic residue [active] 364106013111 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 364106013112 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 364106013113 putative catalytic residues [active] 364106013114 putative nucleotide binding site [chemical binding]; other site 364106013115 putative aspartate binding site [chemical binding]; other site 364106013116 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 364106013117 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 364106013118 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 364106013119 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 364106013120 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 364106013121 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 364106013122 active site 364106013123 metal binding site [ion binding]; metal-binding site 364106013124 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 364106013125 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 364106013126 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 364106013127 active site 364106013128 metal binding site [ion binding]; metal-binding site 364106013129 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 364106013130 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 364106013131 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 364106013132 active site 364106013133 metal binding site [ion binding]; metal-binding site 364106013134 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 364106013135 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 364106013136 FAD binding site [chemical binding]; other site 364106013137 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 364106013138 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 364106013139 heme binding site [chemical binding]; other site 364106013140 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 364106013141 EamA-like transporter family; Region: EamA; pfam00892 364106013142 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 364106013143 EamA-like transporter family; Region: EamA; pfam00892 364106013144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 364106013145 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 364106013146 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 364106013147 dimer interface [polypeptide binding]; other site 364106013148 active site 364106013149 metal binding site [ion binding]; metal-binding site 364106013150 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 364106013151 active site 364106013152 intersubunit interactions; other site 364106013153 catalytic residue [active] 364106013154 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 364106013155 dimerization domain swap beta strand [polypeptide binding]; other site 364106013156 regulatory protein interface [polypeptide binding]; other site 364106013157 active site 364106013158 regulatory phosphorylation site [posttranslational modification]; other site 364106013159 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 364106013160 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 364106013161 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 364106013162 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 364106013163 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 364106013164 active site 364106013165 phosphorylation site [posttranslational modification] 364106013166 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 364106013167 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 364106013168 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 364106013169 active site 364106013170 P-loop; other site 364106013171 phosphorylation site [posttranslational modification] 364106013172 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 364106013173 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 364106013174 dimer interface [polypeptide binding]; other site 364106013175 active site 364106013176 glycine loop; other site 364106013177 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 364106013178 FeS/SAM binding site; other site 364106013179 pyruvate formate lyase II activase; Provisional; Region: PRK10076 364106013180 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 364106013181 active site 364106013182 P-loop; other site 364106013183 phosphorylation site [posttranslational modification] 364106013184 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 364106013185 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106013186 hypothetical protein; Provisional; Region: PRK10649 364106013187 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 364106013188 Sulfatase; Region: Sulfatase; pfam00884 364106013189 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 364106013190 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 364106013191 acetylornithine deacetylase; Provisional; Region: PRK05111 364106013192 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 364106013193 metal binding site [ion binding]; metal-binding site 364106013194 putative dimer interface [polypeptide binding]; other site 364106013195 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 364106013196 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 364106013197 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 364106013198 nucleotide binding site [chemical binding]; other site 364106013199 N-acetyl-L-glutamate binding site [chemical binding]; other site 364106013200 argininosuccinate lyase; Provisional; Region: PRK04833 364106013201 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 364106013202 active sites [active] 364106013203 tetramer interface [polypeptide binding]; other site 364106013204 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 364106013205 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 364106013206 putative active site pocket [active] 364106013207 putative metal binding site [ion binding]; other site 364106013208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106013209 D-galactonate transporter; Region: 2A0114; TIGR00893 364106013210 putative substrate translocation pore; other site 364106013211 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 364106013212 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106013213 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 364106013214 dimerization interface [polypeptide binding]; other site 364106013215 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 364106013216 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 364106013217 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 364106013218 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 364106013219 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 364106013220 metal binding site [ion binding]; metal-binding site 364106013221 putative dimer interface [polypeptide binding]; other site 364106013222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106013223 metabolite-proton symporter; Region: 2A0106; TIGR00883 364106013224 putative substrate translocation pore; other site 364106013225 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 364106013226 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 364106013227 hypothetical protein; Provisional; Region: PRK11056 364106013228 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 364106013229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106013230 S-adenosylmethionine binding site [chemical binding]; other site 364106013231 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 364106013232 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 364106013233 N-terminal plug; other site 364106013234 ligand-binding site [chemical binding]; other site 364106013235 glutamate racemase; Provisional; Region: PRK00865 364106013236 hypothetical protein; Provisional; Region: PRK10039 364106013237 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 364106013238 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 364106013239 Coenzyme A binding pocket [chemical binding]; other site 364106013240 homoserine O-succinyltransferase; Provisional; Region: PRK05368 364106013241 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 364106013242 proposed active site lysine [active] 364106013243 conserved cys residue [active] 364106013244 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 364106013245 malate synthase A; Region: malate_syn_A; TIGR01344 364106013246 active site 364106013247 isocitrate lyase; Provisional; Region: PRK15063 364106013248 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 364106013249 tetramer interface [polypeptide binding]; other site 364106013250 active site 364106013251 Mg2+/Mn2+ binding site [ion binding]; other site 364106013252 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 364106013253 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 364106013254 transcriptional repressor IclR; Provisional; Region: PRK11569 364106013255 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 364106013256 Bacterial transcriptional regulator; Region: IclR; pfam01614 364106013257 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 364106013258 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 364106013259 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 364106013260 substrate binding pocket [chemical binding]; other site 364106013261 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 364106013262 B12 binding site [chemical binding]; other site 364106013263 cobalt ligand [ion binding]; other site 364106013264 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 364106013265 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 364106013266 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 364106013267 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 364106013268 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 364106013269 active site pocket [active] 364106013270 oxyanion hole [active] 364106013271 catalytic triad [active] 364106013272 active site nucleophile [active] 364106013273 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 364106013274 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 364106013275 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 364106013276 putative NAD(P) binding site [chemical binding]; other site 364106013277 catalytic Zn binding site [ion binding]; other site 364106013278 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 364106013279 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 364106013280 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 364106013281 active site 364106013282 phosphorylation site [posttranslational modification] 364106013283 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 364106013284 active pocket/dimerization site; other site 364106013285 active site 364106013286 phosphorylation site [posttranslational modification] 364106013287 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 364106013288 classical (c) SDRs; Region: SDR_c; cd05233 364106013289 NAD(P) binding site [chemical binding]; other site 364106013290 active site 364106013291 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 364106013292 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 364106013293 putative DNA binding site [nucleotide binding]; other site 364106013294 putative Zn2+ binding site [ion binding]; other site 364106013295 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 364106013296 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 364106013297 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 364106013298 RNA binding surface [nucleotide binding]; other site 364106013299 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 364106013300 probable active site [active] 364106013301 hypothetical protein; Provisional; Region: PRK10515 364106013302 aspartate kinase III; Validated; Region: PRK09084 364106013303 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 364106013304 nucleotide binding site [chemical binding]; other site 364106013305 substrate binding site [chemical binding]; other site 364106013306 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 364106013307 lysine allosteric regulatory site; other site 364106013308 dimer interface [polypeptide binding]; other site 364106013309 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 364106013310 dimer interface [polypeptide binding]; other site 364106013311 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 364106013312 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 364106013313 active site 364106013314 dimer interface [polypeptide binding]; other site 364106013315 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 364106013316 dimer interface [polypeptide binding]; other site 364106013317 active site 364106013318 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 364106013319 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 364106013320 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 364106013321 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 364106013322 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 364106013323 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 364106013324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106013325 dimer interface [polypeptide binding]; other site 364106013326 conserved gate region; other site 364106013327 putative PBP binding loops; other site 364106013328 ABC-ATPase subunit interface; other site 364106013329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106013330 dimer interface [polypeptide binding]; other site 364106013331 conserved gate region; other site 364106013332 putative PBP binding loops; other site 364106013333 ABC-ATPase subunit interface; other site 364106013334 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 364106013335 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 364106013336 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 364106013337 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 364106013338 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 364106013339 Walker A/P-loop; other site 364106013340 ATP binding site [chemical binding]; other site 364106013341 Q-loop/lid; other site 364106013342 ABC transporter signature motif; other site 364106013343 Walker B; other site 364106013344 D-loop; other site 364106013345 H-loop/switch region; other site 364106013346 TOBE domain; Region: TOBE_2; pfam08402 364106013347 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 364106013348 trimer interface; other site 364106013349 sugar binding site [chemical binding]; other site 364106013350 maltose regulon periplasmic protein; Provisional; Region: PRK10564 364106013351 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 364106013352 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 364106013353 UbiA prenyltransferase family; Region: UbiA; pfam01040 364106013354 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 364106013355 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 364106013356 putative acyl-acceptor binding pocket; other site 364106013357 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 364106013358 LexA repressor; Validated; Region: PRK00215 364106013359 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 364106013360 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 364106013361 Catalytic site [active] 364106013362 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 364106013363 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 364106013364 hypothetical protein; Provisional; Region: PRK10428 364106013365 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 364106013366 metal binding site 2 [ion binding]; metal-binding site 364106013367 putative DNA binding helix; other site 364106013368 metal binding site 1 [ion binding]; metal-binding site 364106013369 dimer interface [polypeptide binding]; other site 364106013370 structural Zn2+ binding site [ion binding]; other site 364106013371 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 364106013372 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 364106013373 FMN binding site [chemical binding]; other site 364106013374 active site 364106013375 catalytic residues [active] 364106013376 substrate binding site [chemical binding]; other site 364106013377 phage shock protein G; Reviewed; Region: pspG; PRK09459 364106013378 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 364106013379 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 364106013380 NADP binding site [chemical binding]; other site 364106013381 dimer interface [polypeptide binding]; other site 364106013382 L-aspartate oxidase; Provisional; Region: PRK06175 364106013383 FAD binding domain; Region: FAD_binding_2; pfam00890 364106013384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106013385 metabolite-proton symporter; Region: 2A0106; TIGR00883 364106013386 putative substrate translocation pore; other site 364106013387 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 364106013388 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 364106013389 substrate binding site [chemical binding]; other site 364106013390 oxyanion hole (OAH) forming residues; other site 364106013391 trimer interface [polypeptide binding]; other site 364106013392 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 364106013393 Coenzyme A transferase; Region: CoA_trans; smart00882 364106013394 Coenzyme A transferase; Region: CoA_trans; cl17247 364106013395 Transcriptional regulators [Transcription]; Region: PurR; COG1609 364106013396 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 364106013397 DNA binding site [nucleotide binding] 364106013398 domain linker motif; other site 364106013399 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 364106013400 putative dimerization interface [polypeptide binding]; other site 364106013401 putative ligand binding site [chemical binding]; other site 364106013402 replicative DNA helicase; Provisional; Region: PRK08006 364106013403 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 364106013404 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 364106013405 Walker A motif; other site 364106013406 ATP binding site [chemical binding]; other site 364106013407 Walker B motif; other site 364106013408 DNA binding loops [nucleotide binding] 364106013409 alanine racemase; Reviewed; Region: alr; PRK00053 364106013410 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 364106013411 active site 364106013412 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 364106013413 substrate binding site [chemical binding]; other site 364106013414 catalytic residues [active] 364106013415 dimer interface [polypeptide binding]; other site 364106013416 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 364106013417 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 364106013418 active site 364106013419 nucleotide binding site [chemical binding]; other site 364106013420 HIGH motif; other site 364106013421 KMSKS motif; other site 364106013422 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 364106013423 AAA domain; Region: AAA_28; pfam13521 364106013424 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 364106013425 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 364106013426 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106013427 homodimer interface [polypeptide binding]; other site 364106013428 catalytic residue [active] 364106013429 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 364106013430 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 364106013431 TPP-binding site [chemical binding]; other site 364106013432 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 364106013433 dimer interface [polypeptide binding]; other site 364106013434 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 364106013435 E3 interaction surface; other site 364106013436 lipoyl attachment site [posttranslational modification]; other site 364106013437 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 364106013438 e3 binding domain; Region: E3_binding; pfam02817 364106013439 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 364106013440 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 364106013441 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 364106013442 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 364106013443 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 364106013444 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 364106013445 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 364106013446 CoA-ligase; Region: Ligase_CoA; pfam00549 364106013447 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 364106013448 CoA binding domain; Region: CoA_binding; smart00881 364106013449 CoA-ligase; Region: Ligase_CoA; pfam00549 364106013450 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 364106013451 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 364106013452 transmembrane helices; other site 364106013453 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 364106013454 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 364106013455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106013456 active site 364106013457 phosphorylation site [posttranslational modification] 364106013458 intermolecular recognition site; other site 364106013459 dimerization interface [polypeptide binding]; other site 364106013460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106013461 Walker A motif; other site 364106013462 ATP binding site [chemical binding]; other site 364106013463 Walker B motif; other site 364106013464 arginine finger; other site 364106013465 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 364106013466 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 364106013467 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 364106013468 dimer interface [polypeptide binding]; other site 364106013469 phosphorylation site [posttranslational modification] 364106013470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106013471 ATP binding site [chemical binding]; other site 364106013472 Mg2+ binding site [ion binding]; other site 364106013473 G-X-G motif; other site 364106013474 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 364106013475 active site 364106013476 motif I; other site 364106013477 motif II; other site 364106013478 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 364106013479 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 364106013480 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 364106013481 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 364106013482 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 364106013483 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 364106013484 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 364106013485 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 364106013486 dimer interface [polypeptide binding]; other site 364106013487 ssDNA binding site [nucleotide binding]; other site 364106013488 tetramer (dimer of dimers) interface [polypeptide binding]; other site 364106013489 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 364106013490 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 364106013491 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 364106013492 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 364106013493 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 364106013494 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106013495 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 364106013496 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 364106013497 DNA binding residues [nucleotide binding] 364106013498 dimer interface [polypeptide binding]; other site 364106013499 [2Fe-2S] cluster binding site [ion binding]; other site 364106013500 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 364106013501 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 364106013502 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 364106013503 Transcriptional regulator [Transcription]; Region: LysR; COG0583 364106013504 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106013505 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 364106013506 putative dimerization interface [polypeptide binding]; other site 364106013507 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 364106013508 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 364106013509 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 364106013510 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 364106013511 Na binding site [ion binding]; other site 364106013512 Predicted membrane protein [Function unknown]; Region: COG3162 364106013513 acetyl-CoA synthetase; Provisional; Region: PRK00174 364106013514 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 364106013515 active site 364106013516 CoA binding site [chemical binding]; other site 364106013517 acyl-activating enzyme (AAE) consensus motif; other site 364106013518 AMP binding site [chemical binding]; other site 364106013519 acetate binding site [chemical binding]; other site 364106013520 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 364106013521 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 364106013522 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 364106013523 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 364106013524 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 364106013525 heme lyase subunit NrfE; Provisional; Region: PRK10369 364106013526 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 364106013527 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 364106013528 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 364106013529 binding surface 364106013530 TPR motif; other site 364106013531 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 364106013532 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 364106013533 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 364106013534 Sel1-like repeats; Region: SEL1; smart00671 364106013535 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 364106013536 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 364106013537 Walker A/P-loop; other site 364106013538 ATP binding site [chemical binding]; other site 364106013539 Q-loop/lid; other site 364106013540 ABC transporter signature motif; other site 364106013541 Walker B; other site 364106013542 D-loop; other site 364106013543 H-loop/switch region; other site 364106013544 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 364106013545 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 364106013546 Walker A/P-loop; other site 364106013547 ATP binding site [chemical binding]; other site 364106013548 Q-loop/lid; other site 364106013549 ABC transporter signature motif; other site 364106013550 Walker B; other site 364106013551 D-loop; other site 364106013552 H-loop/switch region; other site 364106013553 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 364106013554 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 364106013555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106013556 dimer interface [polypeptide binding]; other site 364106013557 conserved gate region; other site 364106013558 ABC-ATPase subunit interface; other site 364106013559 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 364106013560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106013561 dimer interface [polypeptide binding]; other site 364106013562 conserved gate region; other site 364106013563 putative PBP binding loops; other site 364106013564 ABC-ATPase subunit interface; other site 364106013565 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 364106013566 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 364106013567 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 364106013568 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 364106013569 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 364106013570 multidrug resistance protein MdtN; Provisional; Region: PRK10476 364106013571 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 364106013572 HlyD family secretion protein; Region: HlyD_3; pfam13437 364106013573 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 364106013574 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 364106013575 D-allose kinase; Provisional; Region: PRK09698 364106013576 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 364106013577 nucleotide binding site [chemical binding]; other site 364106013578 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 364106013579 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 364106013580 substrate binding site [chemical binding]; other site 364106013581 hexamer interface [polypeptide binding]; other site 364106013582 metal binding site [ion binding]; metal-binding site 364106013583 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 364106013584 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 364106013585 Walker A/P-loop; other site 364106013586 ATP binding site [chemical binding]; other site 364106013587 Q-loop/lid; other site 364106013588 ABC transporter signature motif; other site 364106013589 Walker B; other site 364106013590 D-loop; other site 364106013591 H-loop/switch region; other site 364106013592 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 364106013593 D-allose transporter subunit; Provisional; Region: PRK09701 364106013594 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 364106013595 ligand binding site [chemical binding]; other site 364106013596 dimerization interface [polypeptide binding]; other site 364106013597 zinc binding site [ion binding]; other site 364106013598 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 364106013599 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 364106013600 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 364106013601 putative active site [active] 364106013602 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 364106013603 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 364106013604 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 364106013605 Coenzyme A binding pocket [chemical binding]; other site 364106013606 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 364106013607 AAA domain; Region: AAA_18; pfam13238 364106013608 active site 364106013609 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 364106013610 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 364106013611 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 364106013612 active site 364106013613 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 364106013614 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 364106013615 Walker A/P-loop; other site 364106013616 ATP binding site [chemical binding]; other site 364106013617 Q-loop/lid; other site 364106013618 ABC transporter signature motif; other site 364106013619 Walker B; other site 364106013620 D-loop; other site 364106013621 H-loop/switch region; other site 364106013622 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 364106013623 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 364106013624 Walker A/P-loop; other site 364106013625 ATP binding site [chemical binding]; other site 364106013626 Q-loop/lid; other site 364106013627 ABC transporter signature motif; other site 364106013628 Walker B; other site 364106013629 D-loop; other site 364106013630 H-loop/switch region; other site 364106013631 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 364106013632 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 364106013633 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 364106013634 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 364106013635 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 364106013636 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 364106013637 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 364106013638 DNA-binding site [nucleotide binding]; DNA binding site 364106013639 UTRA domain; Region: UTRA; pfam07702 364106013640 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 364106013641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 364106013642 dimer interface [polypeptide binding]; other site 364106013643 conserved gate region; other site 364106013644 putative PBP binding loops; other site 364106013645 ABC-ATPase subunit interface; other site 364106013646 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 364106013647 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 364106013648 substrate binding pocket [chemical binding]; other site 364106013649 membrane-bound complex binding site; other site 364106013650 hinge residues; other site 364106013651 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 364106013652 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 364106013653 Walker A/P-loop; other site 364106013654 ATP binding site [chemical binding]; other site 364106013655 Q-loop/lid; other site 364106013656 ABC transporter signature motif; other site 364106013657 Walker B; other site 364106013658 D-loop; other site 364106013659 H-loop/switch region; other site 364106013660 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 364106013661 dimer interface [polypeptide binding]; other site 364106013662 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 364106013663 hypothetical protein; Provisional; Region: PRK10220 364106013664 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 364106013665 PhnA protein; Region: PhnA; pfam03831 364106013666 hypothetical protein; Provisional; Region: PRK09866 364106013667 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 364106013668 G1 box; other site 364106013669 GTP/Mg2+ binding site [chemical binding]; other site 364106013670 G2 box; other site 364106013671 Switch I region; other site 364106013672 G3 box; other site 364106013673 Switch II region; other site 364106013674 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 364106013675 G2 box; other site 364106013676 Switch I region; other site 364106013677 G3 box; other site 364106013678 Switch II region; other site 364106013679 G4 box; other site 364106013680 G5 box; other site 364106013681 YjcZ-like protein; Region: YjcZ; pfam13990 364106013682 proline/glycine betaine transporter; Provisional; Region: PRK10642 364106013683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106013684 putative substrate translocation pore; other site 364106013685 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 364106013686 sensor protein BasS/PmrB; Provisional; Region: PRK10755 364106013687 HAMP domain; Region: HAMP; pfam00672 364106013688 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 364106013689 dimer interface [polypeptide binding]; other site 364106013690 phosphorylation site [posttranslational modification] 364106013691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106013692 ATP binding site [chemical binding]; other site 364106013693 Mg2+ binding site [ion binding]; other site 364106013694 G-X-G motif; other site 364106013695 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 364106013696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106013697 active site 364106013698 phosphorylation site [posttranslational modification] 364106013699 intermolecular recognition site; other site 364106013700 dimerization interface [polypeptide binding]; other site 364106013701 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 364106013702 DNA binding site [nucleotide binding] 364106013703 putative metal dependent hydrolase; Provisional; Region: PRK11598 364106013704 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 364106013705 Sulfatase; Region: Sulfatase; pfam00884 364106013706 arginine:agmatin antiporter; Provisional; Region: PRK10644 364106013707 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 364106013708 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106013709 arginine decarboxylase; Provisional; Region: PRK15029 364106013710 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 364106013711 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 364106013712 homodimer interface [polypeptide binding]; other site 364106013713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106013714 catalytic residue [active] 364106013715 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 364106013716 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 364106013717 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106013718 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106013719 alpha-galactosidase; Provisional; Region: PRK15076 364106013720 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 364106013721 NAD binding site [chemical binding]; other site 364106013722 sugar binding site [chemical binding]; other site 364106013723 divalent metal binding site [ion binding]; other site 364106013724 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 364106013725 dimer interface [polypeptide binding]; other site 364106013726 hypothetical protein; Provisional; Region: PRK09867 364106013727 fumarate hydratase; Provisional; Region: PRK15389 364106013728 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 364106013729 Fumarase C-terminus; Region: Fumerase_C; pfam05683 364106013730 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 364106013731 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 364106013732 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 364106013733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106013734 active site 364106013735 phosphorylation site [posttranslational modification] 364106013736 intermolecular recognition site; other site 364106013737 dimerization interface [polypeptide binding]; other site 364106013738 Transcriptional regulator; Region: CitT; pfam12431 364106013739 sensory histidine kinase DcuS; Provisional; Region: PRK11086 364106013740 PAS domain; Region: PAS; smart00091 364106013741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106013742 ATP binding site [chemical binding]; other site 364106013743 Mg2+ binding site [ion binding]; other site 364106013744 G-X-G motif; other site 364106013745 Uncharacterized conserved protein [Function unknown]; Region: COG3592 364106013746 Predicted acetyltransferase [General function prediction only]; Region: COG2388 364106013747 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 364106013748 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 364106013749 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 364106013750 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 364106013751 dimer interface [polypeptide binding]; other site 364106013752 putative anticodon binding site; other site 364106013753 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 364106013754 motif 1; other site 364106013755 active site 364106013756 motif 2; other site 364106013757 motif 3; other site 364106013758 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 364106013759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106013760 putative substrate translocation pore; other site 364106013761 POT family; Region: PTR2; pfam00854 364106013762 lysine decarboxylase CadA; Provisional; Region: PRK15400 364106013763 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 364106013764 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 364106013765 homodimer interface [polypeptide binding]; other site 364106013766 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106013767 catalytic residue [active] 364106013768 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 364106013769 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 364106013770 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 364106013771 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 364106013772 DNA binding site [nucleotide binding] 364106013773 putative transcriptional regulator; Provisional; Region: PRK11640 364106013774 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 364106013775 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 364106013776 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 364106013777 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 364106013778 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 364106013779 DsbD alpha interface [polypeptide binding]; other site 364106013780 catalytic residues [active] 364106013781 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 364106013782 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 364106013783 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 364106013784 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 364106013785 Aspartase; Region: Aspartase; cd01357 364106013786 active sites [active] 364106013787 tetramer interface [polypeptide binding]; other site 364106013788 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 364106013789 putative transporter; Provisional; Region: PRK11021 364106013790 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 364106013791 oligomerisation interface [polypeptide binding]; other site 364106013792 mobile loop; other site 364106013793 roof hairpin; other site 364106013794 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 364106013795 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 364106013796 ring oligomerisation interface [polypeptide binding]; other site 364106013797 ATP/Mg binding site [chemical binding]; other site 364106013798 stacking interactions; other site 364106013799 hinge regions; other site 364106013800 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 364106013801 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 364106013802 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 364106013803 FeS/SAM binding site; other site 364106013804 elongation factor P; Validated; Region: PRK00529 364106013805 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 364106013806 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 364106013807 RNA binding site [nucleotide binding]; other site 364106013808 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 364106013809 RNA binding site [nucleotide binding]; other site 364106013810 entericidin A; Provisional; Region: PRK09810 364106013811 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 364106013812 multidrug efflux system protein; Provisional; Region: PRK11431 364106013813 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 364106013814 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 364106013815 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 364106013816 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 364106013817 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 364106013818 Iron-sulfur protein interface; other site 364106013819 proximal quinone binding site [chemical binding]; other site 364106013820 C-subunit interface; other site 364106013821 distal quinone binding site; other site 364106013822 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 364106013823 D-subunit interface [polypeptide binding]; other site 364106013824 Iron-sulfur protein interface; other site 364106013825 proximal quinone binding site [chemical binding]; other site 364106013826 distal quinone binding site [chemical binding]; other site 364106013827 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 364106013828 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 364106013829 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 364106013830 L-aspartate oxidase; Provisional; Region: PRK06175 364106013831 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 364106013832 poxB regulator PoxA; Provisional; Region: PRK09350 364106013833 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 364106013834 motif 1; other site 364106013835 dimer interface [polypeptide binding]; other site 364106013836 active site 364106013837 motif 2; other site 364106013838 motif 3; other site 364106013839 inner membrane transporter YjeM; Provisional; Region: PRK15238 364106013840 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 364106013841 putative mechanosensitive channel protein; Provisional; Region: PRK10929 364106013842 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 364106013843 DNA-binding site [nucleotide binding]; DNA binding site 364106013844 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 364106013845 Mechanosensitive ion channel; Region: MS_channel; pfam00924 364106013846 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 364106013847 GTPase RsgA; Reviewed; Region: PRK12288 364106013848 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 364106013849 RNA binding site [nucleotide binding]; other site 364106013850 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 364106013851 GTPase/Zn-binding domain interface [polypeptide binding]; other site 364106013852 GTP/Mg2+ binding site [chemical binding]; other site 364106013853 G4 box; other site 364106013854 G5 box; other site 364106013855 G1 box; other site 364106013856 Switch I region; other site 364106013857 G2 box; other site 364106013858 G3 box; other site 364106013859 Switch II region; other site 364106013860 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 364106013861 catalytic site [active] 364106013862 putative active site [active] 364106013863 putative substrate binding site [chemical binding]; other site 364106013864 dimer interface [polypeptide binding]; other site 364106013865 epoxyqueuosine reductase; Region: TIGR00276 364106013866 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 364106013867 putative carbohydrate kinase; Provisional; Region: PRK10565 364106013868 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 364106013869 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 364106013870 putative substrate binding site [chemical binding]; other site 364106013871 putative ATP binding site [chemical binding]; other site 364106013872 ADP-binding protein; Provisional; Region: PRK10646 364106013873 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 364106013874 AMIN domain; Region: AMIN; pfam11741 364106013875 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 364106013876 active site 364106013877 metal binding site [ion binding]; metal-binding site 364106013878 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 364106013879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106013880 ATP binding site [chemical binding]; other site 364106013881 Mg2+ binding site [ion binding]; other site 364106013882 G-X-G motif; other site 364106013883 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 364106013884 ATP binding site [chemical binding]; other site 364106013885 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 364106013886 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 364106013887 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 364106013888 bacterial Hfq-like; Region: Hfq; cd01716 364106013889 hexamer interface [polypeptide binding]; other site 364106013890 Sm1 motif; other site 364106013891 RNA binding site [nucleotide binding]; other site 364106013892 Sm2 motif; other site 364106013893 GTPase HflX; Provisional; Region: PRK11058 364106013894 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 364106013895 HflX GTPase family; Region: HflX; cd01878 364106013896 G1 box; other site 364106013897 GTP/Mg2+ binding site [chemical binding]; other site 364106013898 Switch I region; other site 364106013899 G2 box; other site 364106013900 G3 box; other site 364106013901 Switch II region; other site 364106013902 G4 box; other site 364106013903 G5 box; other site 364106013904 FtsH protease regulator HflK; Provisional; Region: PRK10930 364106013905 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 364106013906 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 364106013907 FtsH protease regulator HflC; Provisional; Region: PRK11029 364106013908 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 364106013909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 364106013910 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 364106013911 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 364106013912 GDP-binding site [chemical binding]; other site 364106013913 ACT binding site; other site 364106013914 IMP binding site; other site 364106013915 Predicted transcriptional regulator [Transcription]; Region: COG1959 364106013916 transcriptional repressor NsrR; Provisional; Region: PRK11014 364106013917 exoribonuclease R; Provisional; Region: PRK11642 364106013918 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 364106013919 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 364106013920 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 364106013921 RNB domain; Region: RNB; pfam00773 364106013922 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 364106013923 RNA binding site [nucleotide binding]; other site 364106013924 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 364106013925 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 364106013926 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 364106013927 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 364106013928 PspA/IM30 family; Region: PspA_IM30; pfam04012 364106013929 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 364106013930 Predicted membrane protein [Function unknown]; Region: COG3766 364106013931 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 364106013932 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 364106013933 Predicted integral membrane protein [Function unknown]; Region: COG5463 364106013934 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 364106013935 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 364106013936 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 364106013937 FAD binding site [chemical binding]; other site 364106013938 substrate binding site [chemical binding]; other site 364106013939 catalytic residues [active] 364106013940 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 364106013941 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 364106013942 esterase; Provisional; Region: PRK10566 364106013943 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 364106013944 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 364106013945 transcriptional repressor UlaR; Provisional; Region: PRK13509 364106013946 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 364106013947 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 364106013948 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 364106013949 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 364106013950 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 364106013951 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 364106013952 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 364106013953 active site 364106013954 P-loop; other site 364106013955 phosphorylation site [posttranslational modification] 364106013956 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 364106013957 active site 364106013958 phosphorylation site [posttranslational modification] 364106013959 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 364106013960 active site 364106013961 dimer interface [polypeptide binding]; other site 364106013962 magnesium binding site [ion binding]; other site 364106013963 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 364106013964 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 364106013965 AP (apurinic/apyrimidinic) site pocket; other site 364106013966 DNA interaction; other site 364106013967 Metal-binding active site; metal-binding site 364106013968 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 364106013969 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 364106013970 intersubunit interface [polypeptide binding]; other site 364106013971 active site 364106013972 Zn2+ binding site [ion binding]; other site 364106013973 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 364106013974 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 364106013975 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 364106013976 dimer interface [polypeptide binding]; other site 364106013977 ssDNA binding site [nucleotide binding]; other site 364106013978 tetramer (dimer of dimers) interface [polypeptide binding]; other site 364106013979 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 364106013980 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 364106013981 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 364106013982 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 364106013983 Helix-turn-helix domain; Region: HTH_31; pfam13560 364106013984 sequence-specific DNA binding site [nucleotide binding]; other site 364106013985 salt bridge; other site 364106013986 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 364106013987 HipA-like N-terminal domain; Region: HipA_N; pfam07805 364106013988 HipA-like C-terminal domain; Region: HipA_C; pfam07804 364106013989 D-galactonate transporter; Region: 2A0114; TIGR00893 364106013990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106013991 putative substrate translocation pore; other site 364106013992 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 364106013993 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 364106013994 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 364106013995 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 364106013996 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 364106013997 L-aspartate oxidase; Provisional; Region: PRK06175 364106013998 L-aspartate oxidase; Provisional; Region: PRK06175 364106013999 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 364106014000 Coenzyme A transferase; Region: CoA_trans; smart00882 364106014001 Coenzyme A transferase; Region: CoA_trans; cl17247 364106014002 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 364106014003 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 364106014004 substrate binding site [chemical binding]; other site 364106014005 oxyanion hole (OAH) forming residues; other site 364106014006 trimer interface [polypeptide binding]; other site 364106014007 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 364106014008 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 364106014009 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337 364106014010 putative NAD(P) binding site [chemical binding]; other site 364106014011 active site 364106014012 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 364106014013 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 364106014014 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 364106014015 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 364106014016 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 364106014017 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 364106014018 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 364106014019 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 364106014020 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 364106014021 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 364106014022 Hemerythrin-like domain; Region: Hr-like; cd12108 364106014023 Fe binding site [ion binding]; other site 364106014024 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 364106014025 EamA-like transporter family; Region: EamA; pfam00892 364106014026 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 364106014027 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 364106014028 NADP binding site [chemical binding]; other site 364106014029 Predicted transcriptional regulators [Transcription]; Region: COG1733 364106014030 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 364106014031 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 364106014032 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 364106014033 active site 364106014034 metal binding site [ion binding]; metal-binding site 364106014035 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 364106014036 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 364106014037 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 364106014038 active site 364106014039 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 364106014040 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 364106014041 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 364106014042 Domain of unknown function DUF21; Region: DUF21; pfam01595 364106014043 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 364106014044 Transporter associated domain; Region: CorC_HlyC; smart01091 364106014045 methionine sulfoxide reductase A; Provisional; Region: PRK00058 364106014046 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 364106014047 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 364106014048 Surface antigen; Region: Bac_surface_Ag; pfam01103 364106014049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 364106014050 Family of unknown function (DUF490); Region: DUF490; pfam04357 364106014051 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 364106014052 putative active site pocket [active] 364106014053 dimerization interface [polypeptide binding]; other site 364106014054 putative catalytic residue [active] 364106014055 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 364106014056 dimer interface [polypeptide binding]; other site 364106014057 substrate binding site [chemical binding]; other site 364106014058 metal binding sites [ion binding]; metal-binding site 364106014059 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 364106014060 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 364106014061 putative ligand binding site [chemical binding]; other site 364106014062 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 364106014063 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 364106014064 Walker A/P-loop; other site 364106014065 ATP binding site [chemical binding]; other site 364106014066 Q-loop/lid; other site 364106014067 ABC transporter signature motif; other site 364106014068 Walker B; other site 364106014069 D-loop; other site 364106014070 H-loop/switch region; other site 364106014071 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 364106014072 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 364106014073 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 364106014074 TM-ABC transporter signature motif; other site 364106014075 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 364106014076 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 364106014077 TM-ABC transporter signature motif; other site 364106014078 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 364106014079 AMP binding site [chemical binding]; other site 364106014080 metal binding site [ion binding]; metal-binding site 364106014081 active site 364106014082 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 364106014083 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 364106014084 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 364106014085 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 364106014086 hypothetical protein; Provisional; Region: PRK05255 364106014087 peptidase PmbA; Provisional; Region: PRK11040 364106014088 cytochrome b562; Provisional; Region: PRK15058 364106014089 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 364106014090 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 364106014091 FeS/SAM binding site; other site 364106014092 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 364106014093 ATP cone domain; Region: ATP-cone; pfam03477 364106014094 Class III ribonucleotide reductase; Region: RNR_III; cd01675 364106014095 effector binding site; other site 364106014096 active site 364106014097 Zn binding site [ion binding]; other site 364106014098 glycine loop; other site 364106014099 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 364106014100 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 364106014101 Ca binding site [ion binding]; other site 364106014102 active site 364106014103 catalytic site [active] 364106014104 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 364106014105 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 364106014106 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 364106014107 active site turn [active] 364106014108 phosphorylation site [posttranslational modification] 364106014109 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 364106014110 trehalose repressor; Provisional; Region: treR; PRK09492 364106014111 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 364106014112 DNA binding site [nucleotide binding] 364106014113 domain linker motif; other site 364106014114 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 364106014115 dimerization interface [polypeptide binding]; other site 364106014116 ligand binding site [chemical binding]; other site 364106014117 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 364106014118 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 364106014119 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 364106014120 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 364106014121 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 364106014122 motif II; other site 364106014123 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 364106014124 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 364106014125 homotrimer interaction site [polypeptide binding]; other site 364106014126 putative active site [active] 364106014127 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 364106014128 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 364106014129 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 364106014130 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 364106014131 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 364106014132 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 364106014133 PyrBI operon leader peptide; Region: PyrBI_leader; pfam08052 364106014134 Arginine repressor [Transcription]; Region: ArgR; COG1438 364106014135 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 364106014136 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 364106014137 Predicted membrane protein [Function unknown]; Region: COG1288 364106014138 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 364106014139 ornithine carbamoyltransferase; Validated; Region: PRK02102 364106014140 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 364106014141 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 364106014142 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 364106014143 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 364106014144 putative substrate binding site [chemical binding]; other site 364106014145 nucleotide binding site [chemical binding]; other site 364106014146 nucleotide binding site [chemical binding]; other site 364106014147 homodimer interface [polypeptide binding]; other site 364106014148 arginine deiminase; Provisional; Region: PRK01388 364106014149 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 364106014150 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 364106014151 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 364106014152 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 364106014153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 364106014154 RNase E inhibitor protein; Provisional; Region: PRK11191 364106014155 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 364106014156 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 364106014157 Coenzyme A binding pocket [chemical binding]; other site 364106014158 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 364106014159 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 364106014160 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 364106014161 HIGH motif; other site 364106014162 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 364106014163 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 364106014164 active site 364106014165 KMSKS motif; other site 364106014166 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 364106014167 tRNA binding surface [nucleotide binding]; other site 364106014168 anticodon binding site; other site 364106014169 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 364106014170 DNA polymerase III subunit chi; Validated; Region: PRK05728 364106014171 multifunctional aminopeptidase A; Provisional; Region: PRK00913 364106014172 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 364106014173 interface (dimer of trimers) [polypeptide binding]; other site 364106014174 Substrate-binding/catalytic site; other site 364106014175 Zn-binding sites [ion binding]; other site 364106014176 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 364106014177 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 364106014178 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 364106014179 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 364106014180 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 364106014181 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 364106014182 Walker A motif; other site 364106014183 ATP binding site [chemical binding]; other site 364106014184 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 364106014185 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 364106014186 DNA binding site [nucleotide binding] 364106014187 domain linker motif; other site 364106014188 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 364106014189 putative dimerization interface [polypeptide binding]; other site 364106014190 putative ligand binding site [chemical binding]; other site 364106014191 fructuronate transporter; Provisional; Region: PRK10034; cl15264 364106014192 gluconate transporter; Region: gntP; TIGR00791 364106014193 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 364106014194 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 364106014195 NADP binding site [chemical binding]; other site 364106014196 homodimer interface [polypeptide binding]; other site 364106014197 active site 364106014198 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 364106014199 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 364106014200 putative NAD(P) binding site [chemical binding]; other site 364106014201 catalytic Zn binding site [ion binding]; other site 364106014202 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 364106014203 ATP-binding site [chemical binding]; other site 364106014204 Gluconate-6-phosphate binding site [chemical binding]; other site 364106014205 Shikimate kinase; Region: SKI; pfam01202 364106014206 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 364106014207 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 364106014208 putative NAD(P) binding site [chemical binding]; other site 364106014209 putative substrate binding site [chemical binding]; other site 364106014210 catalytic Zn binding site [ion binding]; other site 364106014211 structural Zn binding site [ion binding]; other site 364106014212 dimer interface [polypeptide binding]; other site 364106014213 integrase; Provisional; Region: PRK09692 364106014214 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 364106014215 active site 364106014216 Int/Topo IB signature motif; other site 364106014217 Part of AAA domain; Region: AAA_19; pfam13245 364106014218 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 364106014219 AAA domain; Region: AAA_12; pfam13087 364106014220 C-terminal domain of Escherichia coli uncharacterized protein yjhR and similar proteins; Region: PLDc_yjhR_C_like; cd09118 364106014221 putative active site [active] 364106014222 catalytic site [active] 364106014223 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 364106014224 Sulfatase; Region: Sulfatase; cl17466 364106014225 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 364106014226 MarR family; Region: MarR_2; cl17246 364106014227 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 364106014228 PapG carbohydrate / receptor binding domain (CBD); PapG, the adhesin of the P-pili, is situated at the tip, mediating the attachment of uropathogenic Escherichia coli to the uroepithelium of the human kidney; PapG has a two-domain architecture: a...; Region: PapG_CBD; cd00239 364106014229 putative membrane interaction site; other site 364106014230 receptor/carbohydrate binding site; other site 364106014231 PapG chaperone-binding domain; Region: PapG_C; pfam03628 364106014232 Fimbrial protein; Region: Fimbrial; pfam00419 364106014233 Fimbrial protein; Region: Fimbrial; pfam00419 364106014234 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 364106014235 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 364106014236 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 364106014237 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 364106014238 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 364106014239 PapC N-terminal domain; Region: PapC_N; pfam13954 364106014240 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 364106014241 PapC C-terminal domain; Region: PapC_C; pfam13953 364106014242 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 364106014243 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 364106014244 Adhesin biosynthesis transcription regulatory protein; Region: PapB; pfam03333 364106014245 FaeA-like protein; Region: FaeA; pfam04703 364106014246 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 364106014247 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 364106014248 PapC N-terminal domain; Region: PapC_N; pfam13954 364106014249 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 364106014250 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 364106014251 PapC C-terminal domain; Region: PapC_C; pfam13953 364106014252 putative chaperone protein EcpD; Provisional; Region: PRK09926 364106014253 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 364106014254 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 364106014255 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 364106014256 Predicted membrane protein [Function unknown]; Region: COG2259 364106014257 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 364106014258 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 364106014259 phosphate binding site [ion binding]; other site 364106014260 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 364106014261 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 364106014262 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 364106014263 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 364106014264 Transposase; Region: DEDD_Tnp_IS110; pfam01548 364106014265 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 364106014266 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 364106014267 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 364106014268 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 364106014269 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 364106014270 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 364106014271 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 364106014272 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 364106014273 Transposase; Region: HTH_Tnp_1; pfam01527 364106014274 Winged helix-turn helix; Region: HTH_29; pfam13551 364106014275 Homeodomain-like domain; Region: HTH_23; cl17451 364106014276 Rho-activating domain of cytotoxic necrotizing factor; Region: CNF1; pfam05785 364106014277 Urea transporter; Region: UT; cl01829 364106014278 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 364106014279 HlyD family secretion protein; Region: HlyD_3; pfam13437 364106014280 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 364106014281 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 364106014282 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 364106014283 ATP-binding cassette domain of hemolysin B, subfamily C; Region: ABCC_Hemolysin; cd03252 364106014284 Walker A/P-loop; other site 364106014285 ATP binding site [chemical binding]; other site 364106014286 Q-loop/lid; other site 364106014287 ABC transporter signature motif; other site 364106014288 Walker B; other site 364106014289 D-loop; other site 364106014290 H-loop/switch region; other site 364106014291 RTX N-terminal domain; Region: RTX; pfam02382 364106014292 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 364106014293 RTX C-terminal domain; Region: RTX_C; pfam08339 364106014294 RTX toxin acyltransferase family; Region: HlyC; pfam02794 364106014295 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 364106014296 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 364106014297 Moco binding site; other site 364106014298 metal coordination site [ion binding]; other site 364106014299 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 364106014300 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 364106014301 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106014302 active site 364106014303 phosphorylation site [posttranslational modification] 364106014304 intermolecular recognition site; other site 364106014305 dimerization interface [polypeptide binding]; other site 364106014306 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 364106014307 DNA binding site [nucleotide binding] 364106014308 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 364106014309 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 364106014310 dimer interface [polypeptide binding]; other site 364106014311 phosphorylation site [posttranslational modification] 364106014312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106014313 ATP binding site [chemical binding]; other site 364106014314 Mg2+ binding site [ion binding]; other site 364106014315 G-X-G motif; other site 364106014316 Integrase core domain; Region: rve; pfam00665 364106014317 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025 364106014318 Transposase; Region: HTH_Tnp_1; pfam01527 364106014319 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 364106014320 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 364106014321 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 364106014322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106014323 ATP binding site [chemical binding]; other site 364106014324 Mg2+ binding site [ion binding]; other site 364106014325 G-X-G motif; other site 364106014326 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 364106014327 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 364106014328 cofactor binding site; other site 364106014329 DNA binding site [nucleotide binding] 364106014330 substrate interaction site [chemical binding]; other site 364106014331 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 364106014332 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 364106014333 ImpA domain protein; Region: DUF3702; pfam12486 364106014334 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 364106014335 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 364106014336 haemagglutination activity domain; Region: Haemagg_act; pfam05860 364106014337 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 364106014338 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 364106014339 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 364106014340 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 364106014341 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 364106014342 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 364106014343 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 364106014344 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 364106014345 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 364106014346 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 364106014347 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 364106014348 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 364106014349 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 364106014350 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 364106014351 catalytic residue [active] 364106014352 permease DsdX; Provisional; Region: PRK09921 364106014353 gluconate transporter; Region: gntP; TIGR00791 364106014354 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 364106014355 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 364106014356 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 364106014357 dimerization interface [polypeptide binding]; other site 364106014358 substrate binding pocket [chemical binding]; other site 364106014359 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 364106014360 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 364106014361 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 364106014362 Propanediol utilisation protein PduL; Region: PduL; pfam06130 364106014363 Propanediol utilisation protein PduL; Region: PduL; pfam06130 364106014364 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 364106014365 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 364106014366 Hexamer interface [polypeptide binding]; other site 364106014367 Hexagonal pore residue; other site 364106014368 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 364106014369 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 364106014370 Pyruvate formate lyase; Region: PFL; pfam02901 364106014371 Pyruvate formate lyase; Region: PFL; pfam02901 364106014372 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 364106014373 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 364106014374 dimer interface [polypeptide binding]; other site 364106014375 active site 364106014376 glycine loop; other site 364106014377 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 364106014378 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 364106014379 putative active site [active] 364106014380 metal binding site [ion binding]; metal-binding site 364106014381 Ethanolamine utilisation protein EutN/carboxysome; Region: EutN_CcmL; pfam03319 364106014382 Hexamer/Pentamer interface [polypeptide binding]; other site 364106014383 central pore; other site 364106014384 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 364106014385 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 364106014386 putative catalytic cysteine [active] 364106014387 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 364106014388 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 364106014389 Hexamer interface [polypeptide binding]; other site 364106014390 Hexagonal pore residue; other site 364106014391 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 364106014392 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 364106014393 Hexamer interface [polypeptide binding]; other site 364106014394 Hexagonal pore residue; other site 364106014395 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 364106014396 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 364106014397 Hexamer interface [polypeptide binding]; other site 364106014398 Hexagonal pore residue; other site 364106014399 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 364106014400 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 364106014401 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 364106014402 putative transposase OrfB; Reviewed; Region: PHA02517 364106014403 HTH-like domain; Region: HTH_21; pfam13276 364106014404 Integrase core domain; Region: rve; pfam00665 364106014405 Integrase core domain; Region: rve_3; cl15866 364106014406 Transposase; Region: HTH_Tnp_1; cl17663 364106014407 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 364106014408 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 364106014409 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 364106014410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 364106014411 homodimer interface [polypeptide binding]; other site 364106014412 catalytic residue [active] 364106014413 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 364106014414 Transposase; Region: HTH_Tnp_1; cl17663 364106014415 Integrase core domain; Region: rve; pfam00665 364106014416 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 364106014417 Restriction endonuclease; Region: Mrr_cat; pfam04471 364106014418 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 364106014419 Predicted GTPase [General function prediction only]; Region: COG3596 364106014420 YfjP GTPase; Region: YfjP; cd11383 364106014421 G1 box; other site 364106014422 GTP/Mg2+ binding site [chemical binding]; other site 364106014423 Switch I region; other site 364106014424 G2 box; other site 364106014425 Switch II region; other site 364106014426 G3 box; other site 364106014427 G4 box; other site 364106014428 G5 box; other site 364106014429 HTH domain; Region: HTH_11; cl17392 364106014430 WYL domain; Region: WYL; pfam13280 364106014431 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 364106014432 Domain of unknown function (DUF932); Region: DUF932; pfam06067 364106014433 Antirestriction protein; Region: Antirestrict; pfam03230 364106014434 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 364106014435 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 364106014436 MPN+ (JAMM) motif; other site 364106014437 Zinc-binding site [ion binding]; other site 364106014438 Protein of unknown function (DUF987); Region: DUF987; pfam06174 364106014439 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 364106014440 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 364106014441 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 364106014442 Predicted ATP-dependent Lon-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG4930 364106014443 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 364106014444 HNH endonuclease; Region: HNH_2; pfam13391 364106014445 Domain of unknown function (DUF303); Region: DUF303; pfam03629 364106014446 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 364106014447 Kelch motif; Region: Kelch_1; pfam01344 364106014448 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 364106014449 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 364106014450 Int/Topo IB signature motif; other site 364106014451 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 364106014452 Int/Topo IB signature motif; other site 364106014453 Fimbrial protein; Region: Fimbrial; cl01416 364106014454 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 364106014455 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 364106014456 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 364106014457 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 364106014458 outer membrane usher protein; Provisional; Region: PRK15193 364106014459 PapC N-terminal domain; Region: PapC_N; pfam13954 364106014460 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 364106014461 PapC C-terminal domain; Region: PapC_C; pfam13953 364106014462 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 364106014463 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 364106014464 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 364106014465 mannosyl binding site [chemical binding]; other site 364106014466 Fimbrial protein; Region: Fimbrial; pfam00419 364106014467 mannonate dehydratase; Region: uxuA; TIGR00695 364106014468 mannonate dehydratase; Provisional; Region: PRK03906 364106014469 D-mannonate oxidoreductase; Provisional; Region: PRK15037 364106014470 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 364106014471 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 364106014472 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 364106014473 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 364106014474 DNA-binding site [nucleotide binding]; DNA binding site 364106014475 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 364106014476 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 364106014477 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 364106014478 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 364106014479 active pocket/dimerization site; other site 364106014480 active site 364106014481 phosphorylation site [posttranslational modification] 364106014482 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 364106014483 dimerization domain swap beta strand [polypeptide binding]; other site 364106014484 regulatory protein interface [polypeptide binding]; other site 364106014485 active site 364106014486 regulatory phosphorylation site [posttranslational modification]; other site 364106014487 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 364106014488 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 364106014489 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 364106014490 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 364106014491 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 364106014492 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 364106014493 Dak1 domain; Region: Dak1; pfam02733 364106014494 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 364106014495 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 364106014496 dimer interface [polypeptide binding]; other site 364106014497 active site 364106014498 metal binding site [ion binding]; metal-binding site 364106014499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 364106014500 Major Facilitator Superfamily; Region: MFS_1; pfam07690 364106014501 putative substrate translocation pore; other site 364106014502 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 364106014503 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 364106014504 BCCT family transporter; Region: BCCT; pfam02028 364106014505 glycerate kinase; Region: TIGR00045 364106014506 tartronate semialdehyde reductase; Provisional; Region: PRK15059 364106014507 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 364106014508 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 364106014509 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 364106014510 glyoxylate carboligase; Provisional; Region: PRK11269 364106014511 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 364106014512 PYR/PP interface [polypeptide binding]; other site 364106014513 dimer interface [polypeptide binding]; other site 364106014514 TPP binding site [chemical binding]; other site 364106014515 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 364106014516 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 364106014517 TPP-binding site [chemical binding]; other site 364106014518 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 364106014519 GAF domain; Region: GAF; pfam01590 364106014520 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 364106014521 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106014522 Walker A motif; other site 364106014523 ATP binding site [chemical binding]; other site 364106014524 Walker B motif; other site 364106014525 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 364106014526 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 364106014527 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 364106014528 cell density-dependent motility repressor; Provisional; Region: PRK10082 364106014529 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 364106014530 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 364106014531 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 364106014532 dimer interface [polypeptide binding]; other site 364106014533 active site 364106014534 hypothetical protein; Provisional; Region: PRK10519 364106014535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 364106014536 Nucleoside recognition; Region: Gate; pfam07670 364106014537 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 364106014538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 364106014539 SdiA-regulated; Region: SdiA-regulated; cd09971 364106014540 putative active site [active] 364106014541 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 364106014542 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 364106014543 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 364106014544 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 364106014545 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 364106014546 Predicted membrane protein [Function unknown]; Region: COG2733 364106014547 putative transposase; Provisional; Region: PRK09857 364106014548 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 364106014549 Uncharacterized conserved protein [Function unknown]; Region: COG1479 364106014550 Protein of unknown function DUF262; Region: DUF262; pfam03235 364106014551 Protein of unknown function DUF262; Region: DUF262; pfam03235 364106014552 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 364106014553 Uncharacterized conserved protein [Function unknown]; Region: COG3586 364106014554 endoribonuclease SymE; Provisional; Region: PRK13605 364106014555 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 364106014556 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 364106014557 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 364106014558 HsdM N-terminal domain; Region: HsdM_N; pfam12161 364106014559 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 364106014560 Methyltransferase domain; Region: Methyltransf_26; pfam13659 364106014561 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 364106014562 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 364106014563 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 364106014564 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 364106014565 ATP binding site [chemical binding]; other site 364106014566 putative Mg++ binding site [ion binding]; other site 364106014567 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 364106014568 Mrr N-terminal domain; Region: Mrr_N; pfam14338 364106014569 Restriction endonuclease; Region: Mrr_cat; pfam04471 364106014570 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 364106014571 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 364106014572 P-loop, Walker A motif; other site 364106014573 Base recognition motif; other site 364106014574 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 364106014575 Uncharacterized small protein [Function unknown]; Region: COG2879 364106014576 carbon starvation protein A; Provisional; Region: PRK15015 364106014577 Carbon starvation protein CstA; Region: CstA; pfam02554 364106014578 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 364106014579 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 364106014580 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 364106014581 dimer interface [polypeptide binding]; other site 364106014582 ligand binding site [chemical binding]; other site 364106014583 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 364106014584 dimerization interface [polypeptide binding]; other site 364106014585 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 364106014586 dimer interface [polypeptide binding]; other site 364106014587 putative CheW interface [polypeptide binding]; other site 364106014588 DctM-like transporters; Region: DctM; pfam06808 364106014589 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 364106014590 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 364106014591 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 364106014592 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 364106014593 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 364106014594 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 364106014595 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 364106014596 DNA-binding site [nucleotide binding]; DNA binding site 364106014597 Transcriptional regulators [Transcription]; Region: GntR; COG1802 364106014598 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 364106014599 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 364106014600 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 364106014601 putative NAD(P) binding site [chemical binding]; other site 364106014602 catalytic Zn binding site [ion binding]; other site 364106014603 structural Zn binding site [ion binding]; other site 364106014604 phosphoglycerol transferase I; Provisional; Region: PRK03776 364106014605 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 364106014606 hypothetical protein; Provisional; Region: PRK11667 364106014607 DNA replication protein DnaC; Validated; Region: PRK07952 364106014608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 364106014609 Walker A motif; other site 364106014610 ATP binding site [chemical binding]; other site 364106014611 Walker B motif; other site 364106014612 primosomal protein DnaI; Provisional; Region: PRK02854 364106014613 hypothetical protein; Provisional; Region: PRK09917 364106014614 Uncharacterized conserved protein [Function unknown]; Region: COG2966 364106014615 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 364106014616 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 364106014617 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 364106014618 DNA binding residues [nucleotide binding] 364106014619 dimerization interface [polypeptide binding]; other site 364106014620 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 364106014621 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 364106014622 DNA binding residues [nucleotide binding] 364106014623 dimerization interface [polypeptide binding]; other site 364106014624 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 364106014625 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 364106014626 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 364106014627 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 364106014628 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 364106014629 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 364106014630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106014631 S-adenosylmethionine binding site [chemical binding]; other site 364106014632 DNA polymerase III subunit psi; Validated; Region: PRK06856 364106014633 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 364106014634 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 364106014635 Coenzyme A binding pocket [chemical binding]; other site 364106014636 dUMP phosphatase; Provisional; Region: PRK09449 364106014637 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 364106014638 motif II; other site 364106014639 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 364106014640 integrase; Provisional; Region: PRK09692 364106014641 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 364106014642 active site 364106014643 Int/Topo IB signature motif; other site 364106014644 Protein of unknown function (DUF551); Region: DUF551; pfam04448 364106014645 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 364106014646 active site 364106014647 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 364106014648 Uncharacterized conserved protein [Function unknown]; Region: COG5532 364106014649 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 364106014650 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 364106014651 non-specific DNA binding site [nucleotide binding]; other site 364106014652 salt bridge; other site 364106014653 sequence-specific DNA binding site [nucleotide binding]; other site 364106014654 Predicted transcriptional regulator [Transcription]; Region: COG2932 364106014655 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 364106014656 Catalytic site [active] 364106014657 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 364106014658 non-specific DNA binding site [nucleotide binding]; other site 364106014659 salt bridge; other site 364106014660 sequence-specific DNA binding site [nucleotide binding]; other site 364106014661 Ash protein family; Region: Phage_ASH; pfam10554 364106014662 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 364106014663 Helix-turn-helix domain; Region: HTH_36; pfam13730 364106014664 PerC transcriptional activator; Region: PerC; pfam06069 364106014665 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 364106014666 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 364106014667 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 364106014668 KilA-N domain; Region: KilA-N; pfam04383 364106014669 Protein of unknown function (DUF968); Region: DUF968; pfam06147 364106014670 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 364106014671 possible prophage 364106014672 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 364106014673 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 364106014674 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 364106014675 DNA methylase; Region: N6_N4_Mtase; pfam01555 364106014676 Lysis protein S; Region: Lysis_S; pfam04971 364106014677 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 364106014678 catalytic residues [active] 364106014679 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 364106014680 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 364106014681 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 364106014682 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 364106014683 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 364106014684 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 364106014685 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 364106014686 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 364106014687 oligomer interface [polypeptide binding]; other site 364106014688 active site residues [active] 364106014689 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 364106014690 Uncharacterized conserved protein [Function unknown]; Region: COG5471 364106014691 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 364106014692 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 364106014693 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 364106014694 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 364106014695 Bacterial Ig-like domain 2; Region: BID_2; smart00635 364106014696 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 364106014697 Minor tail protein T; Region: Phage_tail_T; pfam06223 364106014698 Phage-related minor tail protein [Function unknown]; Region: COG5281 364106014699 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 364106014700 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 364106014701 Phage-related protein [Function unknown]; Region: COG4718 364106014702 Phage-related protein [Function unknown]; Region: gp18; COG4672 364106014703 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 364106014704 MPN+ (JAMM) motif; other site 364106014705 Zinc-binding site [ion binding]; other site 364106014706 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 364106014707 NlpC/P60 family; Region: NLPC_P60; cl17555 364106014708 Phage-related protein, tail component [Function unknown]; Region: COG4723 364106014709 Phage-related protein, tail component [Function unknown]; Region: COG4733 364106014710 Putative phage tail protein; Region: Phage-tail_3; pfam13550 364106014711 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 364106014712 Interdomain contacts; other site 364106014713 Cytokine receptor motif; other site 364106014714 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 364106014715 Fibronectin type III protein; Region: DUF3672; pfam12421 364106014716 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 364106014717 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 364106014718 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 364106014719 DinI-like family; Region: DinI; pfam06183 364106014720 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 364106014721 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 364106014722 G1 box; other site 364106014723 putative GEF interaction site [polypeptide binding]; other site 364106014724 GTP/Mg2+ binding site [chemical binding]; other site 364106014725 Switch I region; other site 364106014726 G2 box; other site 364106014727 G3 box; other site 364106014728 Switch II region; other site 364106014729 G4 box; other site 364106014730 G5 box; other site 364106014731 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 364106014732 periplasmic protein; Provisional; Region: PRK10568 364106014733 BON domain; Region: BON; pfam04972 364106014734 BON domain; Region: BON; pfam04972 364106014735 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 364106014736 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 364106014737 active site 364106014738 nucleophile elbow; other site 364106014739 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 364106014740 active site 364106014741 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 364106014742 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 364106014743 FeS/SAM binding site; other site 364106014744 hypothetical protein; Provisional; Region: PRK10977 364106014745 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 364106014746 intersubunit interface [polypeptide binding]; other site 364106014747 active site 364106014748 catalytic residue [active] 364106014749 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 364106014750 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 364106014751 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 364106014752 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 364106014753 phosphopentomutase; Provisional; Region: PRK05362 364106014754 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 364106014755 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 364106014756 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 364106014757 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 364106014758 HipA-like N-terminal domain; Region: HipA_N; pfam07805 364106014759 HipA-like C-terminal domain; Region: HipA_C; pfam07804 364106014760 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 364106014761 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 364106014762 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 364106014763 hypothetical protein; Provisional; Region: PRK11246 364106014764 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 364106014765 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 364106014766 motif II; other site 364106014767 DNA repair protein RadA; Region: sms; TIGR00416 364106014768 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 364106014769 Walker A motif/ATP binding site; other site 364106014770 ATP binding site [chemical binding]; other site 364106014771 Walker B motif; other site 364106014772 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 364106014773 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 364106014774 non-specific DNA binding site [nucleotide binding]; other site 364106014775 salt bridge; other site 364106014776 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 364106014777 sequence-specific DNA binding site [nucleotide binding]; other site 364106014778 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 364106014779 active site 364106014780 (T/H)XGH motif; other site 364106014781 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 364106014782 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 364106014783 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 364106014784 non-specific DNA binding site [nucleotide binding]; other site 364106014785 salt bridge; other site 364106014786 sequence-specific DNA binding site [nucleotide binding]; other site 364106014787 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 364106014788 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 364106014789 Walker A/P-loop; other site 364106014790 ATP binding site [chemical binding]; other site 364106014791 Q-loop/lid; other site 364106014792 ABC transporter signature motif; other site 364106014793 Walker B; other site 364106014794 D-loop; other site 364106014795 H-loop/switch region; other site 364106014796 ABC transporter; Region: ABC_tran_2; pfam12848 364106014797 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 364106014798 lytic murein transglycosylase; Provisional; Region: PRK11619 364106014799 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 364106014800 N-acetyl-D-glucosamine binding site [chemical binding]; other site 364106014801 catalytic residue [active] 364106014802 Trp operon repressor; Provisional; Region: PRK01381 364106014803 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 364106014804 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 364106014805 catalytic core [active] 364106014806 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 364106014807 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 364106014808 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 364106014809 hypothetical protein; Provisional; Region: PRK10756 364106014810 CreA protein; Region: CreA; pfam05981 364106014811 DNA-binding response regulator CreB; Provisional; Region: PRK11083 364106014812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106014813 active site 364106014814 phosphorylation site [posttranslational modification] 364106014815 intermolecular recognition site; other site 364106014816 dimerization interface [polypeptide binding]; other site 364106014817 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 364106014818 DNA binding site [nucleotide binding] 364106014819 sensory histidine kinase CreC; Provisional; Region: PRK11100 364106014820 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 364106014821 dimerization interface [polypeptide binding]; other site 364106014822 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 364106014823 dimer interface [polypeptide binding]; other site 364106014824 phosphorylation site [posttranslational modification] 364106014825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 364106014826 ATP binding site [chemical binding]; other site 364106014827 Mg2+ binding site [ion binding]; other site 364106014828 G-X-G motif; other site 364106014829 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 364106014830 two-component response regulator; Provisional; Region: PRK11173 364106014831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 364106014832 active site 364106014833 phosphorylation site [posttranslational modification] 364106014834 intermolecular recognition site; other site 364106014835 dimerization interface [polypeptide binding]; other site 364106014836 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 364106014837 DNA binding site [nucleotide binding] 364106014838 putative RNA methyltransferase; Provisional; Region: PRK10433 364106014839 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050