-- dump date 20140619_091334 -- class Genbank::misc_feature -- table misc_feature_note -- id note 566546000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 566546000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 566546000003 putative catalytic residues [active] 566546000004 putative nucleotide binding site [chemical binding]; other site 566546000005 putative aspartate binding site [chemical binding]; other site 566546000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 566546000007 dimer interface [polypeptide binding]; other site 566546000008 putative threonine allosteric regulatory site; other site 566546000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 566546000010 putative threonine allosteric regulatory site; other site 566546000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 566546000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 566546000013 homoserine kinase; Region: thrB; TIGR00191 566546000014 Protein of unknown function; Region: YhfT; pfam10797 566546000015 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 566546000016 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 566546000017 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 566546000018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546000019 catalytic residue [active] 566546000020 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 566546000021 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 566546000022 Transposase; Region: DEDD_Tnp_IS110; pfam01548 566546000023 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 566546000024 hypothetical protein; Validated; Region: PRK02101 566546000025 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 566546000026 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 566546000027 transaldolase-like protein; Provisional; Region: PTZ00411 566546000028 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 566546000029 active site 566546000030 dimer interface [polypeptide binding]; other site 566546000031 catalytic residue [active] 566546000032 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 566546000033 MPT binding site; other site 566546000034 trimer interface [polypeptide binding]; other site 566546000035 hypothetical protein; Provisional; Region: PRK10659 566546000036 hypothetical protein; Provisional; Region: PRK10236 566546000037 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 566546000038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 566546000039 hypothetical protein; Provisional; Region: PRK10154 566546000040 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 566546000041 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 566546000042 nucleotide binding site [chemical binding]; other site 566546000043 NEF interaction site [polypeptide binding]; other site 566546000044 SBD interface [polypeptide binding]; other site 566546000045 chaperone protein DnaJ; Provisional; Region: PRK10767 566546000046 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 566546000047 HSP70 interaction site [polypeptide binding]; other site 566546000048 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 566546000049 substrate binding site [polypeptide binding]; other site 566546000050 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 566546000051 Zn binding sites [ion binding]; other site 566546000052 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 566546000053 dimer interface [polypeptide binding]; other site 566546000054 Hok/gef family; Region: HOK_GEF; pfam01848 566546000055 Hok/gef family; Region: HOK_GEF; pfam01848 566546000056 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 566546000057 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 566546000058 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546000059 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 566546000060 putative dimerization interface [polypeptide binding]; other site 566546000061 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 566546000062 PapC C-terminal domain; Region: PapC_C; pfam13953 566546000063 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 566546000064 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 566546000065 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 566546000066 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 566546000067 active site 566546000068 Riboflavin kinase; Region: Flavokinase; smart00904 566546000069 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 566546000070 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 566546000071 HIGH motif; other site 566546000072 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 566546000073 active site 566546000074 KMSKS motif; other site 566546000075 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 566546000076 tRNA binding surface [nucleotide binding]; other site 566546000077 anticodon binding site; other site 566546000078 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 566546000079 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 566546000080 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 566546000081 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 566546000082 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 566546000083 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 566546000084 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 566546000085 active site 566546000086 tetramer interface [polypeptide binding]; other site 566546000087 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 566546000088 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 566546000089 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 566546000090 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 566546000091 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 566546000092 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 566546000093 catalytic site [active] 566546000094 subunit interface [polypeptide binding]; other site 566546000095 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 566546000096 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 566546000097 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 566546000098 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 566546000099 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 566546000100 ATP-grasp domain; Region: ATP-grasp_4; cl17255 566546000101 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 566546000102 IMP binding site; other site 566546000103 dimer interface [polypeptide binding]; other site 566546000104 interdomain contacts; other site 566546000105 partial ornithine binding site; other site 566546000106 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 566546000107 carnitine operon protein CaiE; Provisional; Region: PRK13627 566546000108 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 566546000109 putative trimer interface [polypeptide binding]; other site 566546000110 putative metal binding site [ion binding]; other site 566546000111 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 566546000112 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 566546000113 substrate binding site [chemical binding]; other site 566546000114 oxyanion hole (OAH) forming residues; other site 566546000115 trimer interface [polypeptide binding]; other site 566546000116 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 566546000117 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 566546000118 acyl-activating enzyme (AAE) consensus motif; other site 566546000119 putative AMP binding site [chemical binding]; other site 566546000120 putative active site [active] 566546000121 putative CoA binding site [chemical binding]; other site 566546000122 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 566546000123 CoA-transferase family III; Region: CoA_transf_3; pfam02515 566546000124 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 566546000125 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 566546000126 active site 566546000127 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 566546000128 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 566546000129 Ligand binding site [chemical binding]; other site 566546000130 Electron transfer flavoprotein domain; Region: ETF; pfam01012 566546000131 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 566546000132 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 566546000133 Ligand binding site [chemical binding]; other site 566546000134 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 566546000135 putative oxidoreductase FixC; Provisional; Region: PRK10157 566546000136 ferredoxin-like protein FixX; Provisional; Region: PRK15449 566546000137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546000138 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 566546000139 putative substrate translocation pore; other site 566546000140 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 566546000141 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 566546000142 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 566546000143 TrkA-N domain; Region: TrkA_N; pfam02254 566546000144 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 566546000145 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 566546000146 folate binding site [chemical binding]; other site 566546000147 NADP+ binding site [chemical binding]; other site 566546000148 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 566546000149 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 566546000150 active site 566546000151 metal binding site [ion binding]; metal-binding site 566546000152 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 566546000153 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 566546000154 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 566546000155 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 566546000156 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 566546000157 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 566546000158 SurA N-terminal domain; Region: SurA_N; pfam09312 566546000159 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 566546000160 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 566546000161 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 566546000162 OstA-like protein; Region: OstA; pfam03968 566546000163 Organic solvent tolerance protein; Region: OstA_C; pfam04453 566546000164 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 566546000165 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 566546000166 putative metal binding site [ion binding]; other site 566546000167 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 566546000168 HSP70 interaction site [polypeptide binding]; other site 566546000169 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 566546000170 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 566546000171 active site 566546000172 ATP-dependent helicase HepA; Validated; Region: PRK04914 566546000173 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 566546000174 ATP binding site [chemical binding]; other site 566546000175 putative Mg++ binding site [ion binding]; other site 566546000176 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 566546000177 nucleotide binding region [chemical binding]; other site 566546000178 ATP-binding site [chemical binding]; other site 566546000179 DNA polymerase II; Reviewed; Region: PRK05762 566546000180 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 566546000181 active site 566546000182 catalytic site [active] 566546000183 substrate binding site [chemical binding]; other site 566546000184 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 566546000185 active site 566546000186 metal-binding site 566546000187 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 566546000188 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 566546000189 intersubunit interface [polypeptide binding]; other site 566546000190 active site 566546000191 Zn2+ binding site [ion binding]; other site 566546000192 L-arabinose isomerase; Provisional; Region: PRK02929 566546000193 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 566546000194 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 566546000195 trimer interface [polypeptide binding]; other site 566546000196 putative substrate binding site [chemical binding]; other site 566546000197 putative metal binding site [ion binding]; other site 566546000198 ribulokinase; Provisional; Region: PRK04123 566546000199 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 566546000200 N- and C-terminal domain interface [polypeptide binding]; other site 566546000201 active site 566546000202 MgATP binding site [chemical binding]; other site 566546000203 catalytic site [active] 566546000204 metal binding site [ion binding]; metal-binding site 566546000205 carbohydrate binding site [chemical binding]; other site 566546000206 homodimer interface [polypeptide binding]; other site 566546000207 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 566546000208 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 566546000209 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546000210 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546000211 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 566546000212 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 566546000213 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 566546000214 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 566546000215 Walker A/P-loop; other site 566546000216 ATP binding site [chemical binding]; other site 566546000217 Q-loop/lid; other site 566546000218 ABC transporter signature motif; other site 566546000219 Walker B; other site 566546000220 D-loop; other site 566546000221 H-loop/switch region; other site 566546000222 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 566546000223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546000224 dimer interface [polypeptide binding]; other site 566546000225 conserved gate region; other site 566546000226 putative PBP binding loops; other site 566546000227 ABC-ATPase subunit interface; other site 566546000228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546000229 dimer interface [polypeptide binding]; other site 566546000230 conserved gate region; other site 566546000231 putative PBP binding loops; other site 566546000232 ABC-ATPase subunit interface; other site 566546000233 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 566546000234 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 566546000235 transcriptional regulator SgrR; Provisional; Region: PRK13626 566546000236 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 566546000237 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 566546000238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546000239 sugar efflux transporter; Region: 2A0120; TIGR00899 566546000240 putative substrate translocation pore; other site 566546000241 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 566546000242 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 566546000243 substrate binding site [chemical binding]; other site 566546000244 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 566546000245 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 566546000246 substrate binding site [chemical binding]; other site 566546000247 ligand binding site [chemical binding]; other site 566546000248 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 566546000249 tartrate dehydrogenase; Region: TTC; TIGR02089 566546000250 2-isopropylmalate synthase; Validated; Region: PRK00915 566546000251 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 566546000252 active site 566546000253 catalytic residues [active] 566546000254 metal binding site [ion binding]; metal-binding site 566546000255 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 566546000256 leu operon leader peptide; Provisional; Region: PRK09925 566546000257 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 566546000258 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546000259 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 566546000260 putative substrate binding pocket [chemical binding]; other site 566546000261 putative dimerization interface [polypeptide binding]; other site 566546000262 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 566546000263 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 566546000264 PYR/PP interface [polypeptide binding]; other site 566546000265 dimer interface [polypeptide binding]; other site 566546000266 TPP binding site [chemical binding]; other site 566546000267 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 566546000268 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 566546000269 TPP-binding site [chemical binding]; other site 566546000270 dimer interface [polypeptide binding]; other site 566546000271 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 566546000272 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 566546000273 putative valine binding site [chemical binding]; other site 566546000274 dimer interface [polypeptide binding]; other site 566546000275 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 566546000276 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 566546000277 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 566546000278 DNA binding site [nucleotide binding] 566546000279 domain linker motif; other site 566546000280 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 566546000281 dimerization interface [polypeptide binding]; other site 566546000282 ligand binding site [chemical binding]; other site 566546000283 mraZ protein; Region: TIGR00242 566546000284 MraZ protein; Region: MraZ; pfam02381 566546000285 MraZ protein; Region: MraZ; pfam02381 566546000286 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 566546000287 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 566546000288 cell division protein FtsL; Provisional; Region: PRK10772 566546000289 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 566546000290 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 566546000291 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 566546000292 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 566546000293 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 566546000294 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 566546000295 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 566546000296 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 566546000297 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 566546000298 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 566546000299 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 566546000300 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 566546000301 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 566546000302 Mg++ binding site [ion binding]; other site 566546000303 putative catalytic motif [active] 566546000304 putative substrate binding site [chemical binding]; other site 566546000305 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 566546000306 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 566546000307 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 566546000308 cell division protein FtsW; Provisional; Region: PRK10774 566546000309 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 566546000310 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 566546000311 active site 566546000312 homodimer interface [polypeptide binding]; other site 566546000313 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 566546000314 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 566546000315 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 566546000316 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 566546000317 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 566546000318 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 566546000319 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 566546000320 cell division protein FtsQ; Provisional; Region: PRK10775 566546000321 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 566546000322 Cell division protein FtsQ; Region: FtsQ; pfam03799 566546000323 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 566546000324 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 566546000325 Cell division protein FtsA; Region: FtsA; pfam14450 566546000326 cell division protein FtsZ; Validated; Region: PRK09330 566546000327 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 566546000328 nucleotide binding site [chemical binding]; other site 566546000329 SulA interaction site; other site 566546000330 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 566546000331 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 566546000332 SecA regulator SecM; Provisional; Region: PRK02943 566546000333 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 566546000334 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 566546000335 SEC-C motif; Region: SEC-C; pfam02810 566546000336 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 566546000337 active site 566546000338 8-oxo-dGMP binding site [chemical binding]; other site 566546000339 nudix motif; other site 566546000340 metal binding site [ion binding]; metal-binding site 566546000341 DNA gyrase inhibitor; Reviewed; Region: PRK00418 566546000342 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 566546000343 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 566546000344 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 566546000345 CoA-binding site [chemical binding]; other site 566546000346 ATP-binding [chemical binding]; other site 566546000347 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 566546000348 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 566546000349 active site 566546000350 pseudogene, assembly protein in type IV pilin biogenesis, transmembrane protein 566546000351 hypothetical protein; Provisional; Region: PRK10436 566546000352 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 566546000353 Walker A motif; other site 566546000354 ATP binding site [chemical binding]; other site 566546000355 Walker B motif; other site 566546000356 putative major pilin subunit; Provisional; Region: PRK10574 566546000357 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 566546000358 Pilin (bacterial filament); Region: Pilin; pfam00114 566546000359 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 566546000360 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 566546000361 dimerization interface [polypeptide binding]; other site 566546000362 active site 566546000363 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 566546000364 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 566546000365 amidase catalytic site [active] 566546000366 Zn binding residues [ion binding]; other site 566546000367 substrate binding site [chemical binding]; other site 566546000368 regulatory protein AmpE; Provisional; Region: PRK10987 566546000369 aromatic amino acid transporter; Provisional; Region: PRK10238 566546000370 Transcriptional regulators [Transcription]; Region: FadR; COG2186 566546000371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 566546000372 DNA-binding site [nucleotide binding]; DNA binding site 566546000373 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 566546000374 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 566546000375 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 566546000376 dimer interface [polypeptide binding]; other site 566546000377 TPP-binding site [chemical binding]; other site 566546000378 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 566546000379 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 566546000380 E3 interaction surface; other site 566546000381 lipoyl attachment site [posttranslational modification]; other site 566546000382 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 566546000383 E3 interaction surface; other site 566546000384 lipoyl attachment site [posttranslational modification]; other site 566546000385 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 566546000386 E3 interaction surface; other site 566546000387 lipoyl attachment site [posttranslational modification]; other site 566546000388 e3 binding domain; Region: E3_binding; pfam02817 566546000389 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 566546000390 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 566546000391 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 566546000392 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 566546000393 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 566546000394 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 566546000395 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 566546000396 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 566546000397 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 566546000398 substrate binding site [chemical binding]; other site 566546000399 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 566546000400 substrate binding site [chemical binding]; other site 566546000401 ligand binding site [chemical binding]; other site 566546000402 hypothetical protein; Provisional; Region: PRK05248 566546000403 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 566546000404 spermidine synthase; Provisional; Region: PRK00811 566546000405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546000406 S-adenosylmethionine binding site [chemical binding]; other site 566546000407 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 566546000408 multicopper oxidase; Provisional; Region: PRK10965 566546000409 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 566546000410 Multicopper oxidase; Region: Cu-oxidase; pfam00394 566546000411 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 566546000412 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 566546000413 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 566546000414 Trp docking motif [polypeptide binding]; other site 566546000415 putative active site [active] 566546000416 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 566546000417 active site 566546000418 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 566546000419 active site clefts [active] 566546000420 zinc binding site [ion binding]; other site 566546000421 dimer interface [polypeptide binding]; other site 566546000422 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 566546000423 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 566546000424 Walker A/P-loop; other site 566546000425 ATP binding site [chemical binding]; other site 566546000426 Q-loop/lid; other site 566546000427 ABC transporter signature motif; other site 566546000428 Walker B; other site 566546000429 D-loop; other site 566546000430 H-loop/switch region; other site 566546000431 inner membrane transport permease; Provisional; Region: PRK15066 566546000432 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 566546000433 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 566546000434 active pocket/dimerization site; other site 566546000435 active site 566546000436 phosphorylation site [posttranslational modification] 566546000437 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 566546000438 putative active site [active] 566546000439 putative metal binding site [ion binding]; other site 566546000440 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 566546000441 tetramerization interface [polypeptide binding]; other site 566546000442 active site 566546000443 Uncharacterized conserved protein [Function unknown]; Region: COG5464 566546000444 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 566546000445 pantoate--beta-alanine ligase; Region: panC; TIGR00018 566546000446 Pantoate-beta-alanine ligase; Region: PanC; cd00560 566546000447 active site 566546000448 ATP-binding site [chemical binding]; other site 566546000449 pantoate-binding site; other site 566546000450 HXXH motif; other site 566546000451 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 566546000452 oligomerization interface [polypeptide binding]; other site 566546000453 active site 566546000454 metal binding site [ion binding]; metal-binding site 566546000455 putative fimbrial-like adhesin protein; Provisional; Region: PRK09723 566546000456 putative fimbrial protein StaF; Provisional; Region: PRK15262 566546000457 putative fimbrial protein StaE; Provisional; Region: PRK15263 566546000458 Fimbrial protein; Region: Fimbrial; cl01416 566546000459 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 566546000460 PapC N-terminal domain; Region: PapC_N; pfam13954 566546000461 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 566546000462 PapC C-terminal domain; Region: PapC_C; pfam13953 566546000463 putative chaperone protein EcpD; Provisional; Region: PRK09926 566546000464 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 566546000465 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 566546000466 Fimbrial protein; Region: Fimbrial; cl01416 566546000467 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 566546000468 catalytic center binding site [active] 566546000469 ATP binding site [chemical binding]; other site 566546000470 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 566546000471 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 566546000472 active site 566546000473 NTP binding site [chemical binding]; other site 566546000474 metal binding triad [ion binding]; metal-binding site 566546000475 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 566546000476 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 566546000477 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 566546000478 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 566546000479 active site 566546000480 nucleotide binding site [chemical binding]; other site 566546000481 HIGH motif; other site 566546000482 KMSKS motif; other site 566546000483 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 566546000484 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 566546000485 2'-5' RNA ligase; Provisional; Region: PRK15124 566546000486 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 566546000487 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 566546000488 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 566546000489 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 566546000490 ATP binding site [chemical binding]; other site 566546000491 putative Mg++ binding site [ion binding]; other site 566546000492 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 566546000493 nucleotide binding region [chemical binding]; other site 566546000494 ATP-binding site [chemical binding]; other site 566546000495 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 566546000496 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 566546000497 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 566546000498 Transglycosylase; Region: Transgly; pfam00912 566546000499 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 566546000500 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 566546000501 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 566546000502 N-terminal plug; other site 566546000503 ligand-binding site [chemical binding]; other site 566546000504 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 566546000505 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 566546000506 Walker A/P-loop; other site 566546000507 ATP binding site [chemical binding]; other site 566546000508 Q-loop/lid; other site 566546000509 ABC transporter signature motif; other site 566546000510 Walker B; other site 566546000511 D-loop; other site 566546000512 H-loop/switch region; other site 566546000513 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 566546000514 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 566546000515 siderophore binding site; other site 566546000516 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 566546000517 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 566546000518 ABC-ATPase subunit interface; other site 566546000519 dimer interface [polypeptide binding]; other site 566546000520 putative PBP binding regions; other site 566546000521 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 566546000522 ABC-ATPase subunit interface; other site 566546000523 dimer interface [polypeptide binding]; other site 566546000524 putative PBP binding regions; other site 566546000525 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 566546000526 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 566546000527 inhibitor-cofactor binding pocket; inhibition site 566546000528 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546000529 catalytic residue [active] 566546000530 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 566546000531 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 566546000532 Cl- selectivity filter; other site 566546000533 Cl- binding residues [ion binding]; other site 566546000534 pore gating glutamate residue; other site 566546000535 dimer interface [polypeptide binding]; other site 566546000536 H+/Cl- coupling transport residue; other site 566546000537 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 566546000538 hypothetical protein; Provisional; Region: PRK10578 566546000539 UPF0126 domain; Region: UPF0126; pfam03458 566546000540 UPF0126 domain; Region: UPF0126; pfam03458 566546000541 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 566546000542 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 566546000543 cobalamin binding residues [chemical binding]; other site 566546000544 putative BtuC binding residues; other site 566546000545 dimer interface [polypeptide binding]; other site 566546000546 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 566546000547 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 566546000548 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 566546000549 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 566546000550 Zn2+ binding site [ion binding]; other site 566546000551 Mg2+ binding site [ion binding]; other site 566546000552 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 566546000553 serine endoprotease; Provisional; Region: PRK10942 566546000554 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 566546000555 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 566546000556 protein binding site [polypeptide binding]; other site 566546000557 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 566546000558 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 566546000559 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 566546000560 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 566546000561 hypothetical protein; Provisional; Region: PRK13677 566546000562 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 566546000563 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 566546000564 trimer interface [polypeptide binding]; other site 566546000565 active site 566546000566 substrate binding site [chemical binding]; other site 566546000567 CoA binding site [chemical binding]; other site 566546000568 PII uridylyl-transferase; Provisional; Region: PRK05007 566546000569 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 566546000570 metal binding triad; other site 566546000571 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 566546000572 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 566546000573 Zn2+ binding site [ion binding]; other site 566546000574 Mg2+ binding site [ion binding]; other site 566546000575 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 566546000576 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 566546000577 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 566546000578 active site 566546000579 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 566546000580 rRNA interaction site [nucleotide binding]; other site 566546000581 S8 interaction site; other site 566546000582 putative laminin-1 binding site; other site 566546000583 elongation factor Ts; Provisional; Region: tsf; PRK09377 566546000584 UBA/TS-N domain; Region: UBA; pfam00627 566546000585 Elongation factor TS; Region: EF_TS; pfam00889 566546000586 Elongation factor TS; Region: EF_TS; pfam00889 566546000587 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 566546000588 putative nucleotide binding site [chemical binding]; other site 566546000589 uridine monophosphate binding site [chemical binding]; other site 566546000590 homohexameric interface [polypeptide binding]; other site 566546000591 ribosome recycling factor; Reviewed; Region: frr; PRK00083 566546000592 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 566546000593 hinge region; other site 566546000594 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 566546000595 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 566546000596 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 566546000597 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 566546000598 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 566546000599 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 566546000600 catalytic residue [active] 566546000601 putative FPP diphosphate binding site; other site 566546000602 putative FPP binding hydrophobic cleft; other site 566546000603 dimer interface [polypeptide binding]; other site 566546000604 putative IPP diphosphate binding site; other site 566546000605 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 566546000606 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 566546000607 zinc metallopeptidase RseP; Provisional; Region: PRK10779 566546000608 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 566546000609 active site 566546000610 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 566546000611 protein binding site [polypeptide binding]; other site 566546000612 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 566546000613 putative substrate binding region [chemical binding]; other site 566546000614 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 566546000615 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 566546000616 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 566546000617 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 566546000618 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 566546000619 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 566546000620 Surface antigen; Region: Bac_surface_Ag; pfam01103 566546000621 periplasmic chaperone; Provisional; Region: PRK10780 566546000622 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 566546000623 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 566546000624 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 566546000625 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 566546000626 trimer interface [polypeptide binding]; other site 566546000627 active site 566546000628 UDP-GlcNAc binding site [chemical binding]; other site 566546000629 lipid binding site [chemical binding]; lipid-binding site 566546000630 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 566546000631 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 566546000632 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 566546000633 active site 566546000634 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 566546000635 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 566546000636 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 566546000637 RNA/DNA hybrid binding site [nucleotide binding]; other site 566546000638 active site 566546000639 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 566546000640 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 566546000641 putative active site [active] 566546000642 putative PHP Thumb interface [polypeptide binding]; other site 566546000643 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 566546000644 generic binding surface II; other site 566546000645 generic binding surface I; other site 566546000646 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 566546000647 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 566546000648 lysine decarboxylase LdcC; Provisional; Region: PRK15399 566546000649 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 566546000650 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 566546000651 homodimer interface [polypeptide binding]; other site 566546000652 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546000653 catalytic residue [active] 566546000654 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 566546000655 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 566546000656 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 566546000657 putative metal binding site [ion binding]; other site 566546000658 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 566546000659 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 566546000660 Ligand Binding Site [chemical binding]; other site 566546000661 TilS substrate binding domain; Region: TilS; pfam09179 566546000662 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 566546000663 Rho-binding antiterminator; Provisional; Region: PRK11625 566546000664 hypothetical protein; Provisional; Region: PRK04964 566546000665 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 566546000666 hypothetical protein; Provisional; Region: PRK09256 566546000667 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 566546000668 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 566546000669 NlpE N-terminal domain; Region: NlpE; pfam04170 566546000670 hypothetical protein; Provisional; Region: PRK11479 566546000671 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 566546000672 prolyl-tRNA synthetase; Provisional; Region: PRK09194 566546000673 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 566546000674 dimer interface [polypeptide binding]; other site 566546000675 motif 1; other site 566546000676 active site 566546000677 motif 2; other site 566546000678 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 566546000679 putative deacylase active site [active] 566546000680 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 566546000681 active site 566546000682 motif 3; other site 566546000683 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 566546000684 anticodon binding site; other site 566546000685 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 566546000686 homodimer interaction site [polypeptide binding]; other site 566546000687 cofactor binding site; other site 566546000688 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 566546000689 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 566546000690 lipoprotein, YaeC family; Region: TIGR00363 566546000691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546000692 dimer interface [polypeptide binding]; other site 566546000693 conserved gate region; other site 566546000694 ABC-ATPase subunit interface; other site 566546000695 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 566546000696 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 566546000697 Walker A/P-loop; other site 566546000698 ATP binding site [chemical binding]; other site 566546000699 Q-loop/lid; other site 566546000700 ABC transporter signature motif; other site 566546000701 Walker B; other site 566546000702 D-loop; other site 566546000703 H-loop/switch region; other site 566546000704 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 566546000705 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 566546000706 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 566546000707 active site 566546000708 motif I; other site 566546000709 motif II; other site 566546000710 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 566546000711 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 566546000712 active site 566546000713 catalytic tetrad [active] 566546000714 Transcriptional regulator [Transcription]; Region: LysR; COG0583 566546000715 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546000716 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 566546000717 putative effector binding pocket; other site 566546000718 dimerization interface [polypeptide binding]; other site 566546000719 hypothetical protein; Provisional; Region: PRK05421 566546000720 putative catalytic site [active] 566546000721 putative metal binding site [ion binding]; other site 566546000722 putative phosphate binding site [ion binding]; other site 566546000723 putative catalytic site [active] 566546000724 putative phosphate binding site [ion binding]; other site 566546000725 putative metal binding site [ion binding]; other site 566546000726 Methyltransferase domain; Region: Methyltransf_31; pfam13847 566546000727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546000728 S-adenosylmethionine binding site [chemical binding]; other site 566546000729 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 566546000730 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 566546000731 N-acetyl-D-glucosamine binding site [chemical binding]; other site 566546000732 catalytic residue [active] 566546000733 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 566546000734 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 566546000735 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 566546000736 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 566546000737 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 566546000738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546000739 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 566546000740 RNA/DNA hybrid binding site [nucleotide binding]; other site 566546000741 active site 566546000742 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 566546000743 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 566546000744 active site 566546000745 catalytic site [active] 566546000746 substrate binding site [chemical binding]; other site 566546000747 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 566546000748 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 566546000749 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 566546000750 ImpA domain protein; Region: DUF3702; pfam12486 566546000751 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 566546000752 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 566546000753 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 566546000754 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 566546000755 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 566546000756 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 566546000757 type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360 566546000758 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 566546000759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546000760 Walker A motif; other site 566546000761 ATP binding site [chemical binding]; other site 566546000762 Walker B motif; other site 566546000763 arginine finger; other site 566546000764 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546000765 Walker A motif; other site 566546000766 ATP binding site [chemical binding]; other site 566546000767 Walker B motif; other site 566546000768 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 566546000769 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 566546000770 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 566546000771 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 566546000772 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 566546000773 Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular transport; Signal transduction mechanisms]; Region: COG3456 566546000774 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 566546000775 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 566546000776 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 566546000777 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 566546000778 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 566546000779 Protein of unknown function (DUF877); Region: DUF877; pfam05943 566546000780 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 566546000781 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 566546000782 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 566546000783 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 566546000784 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 566546000785 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 566546000786 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 566546000787 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 566546000788 RHS Repeat; Region: RHS_repeat; pfam05593 566546000789 RHS Repeat; Region: RHS_repeat; pfam05593 566546000790 RHS Repeat; Region: RHS_repeat; pfam05593 566546000791 RHS Repeat; Region: RHS_repeat; pfam05593 566546000792 RHS Repeat; Region: RHS_repeat; cl11982 566546000793 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 566546000794 RHS Repeat; Region: RHS_repeat; pfam05593 566546000795 RHS Repeat; Region: RHS_repeat; pfam05593 566546000796 RHS protein; Region: RHS; pfam03527 566546000797 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 566546000798 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 566546000799 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 566546000800 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 566546000801 Transposase [DNA replication, recombination, and repair]; Region: COG5433 566546000802 Transposase [DNA replication, recombination, and repair]; Region: COG5433 566546000803 C-N hydrolase family amidase; Provisional; Region: PRK10438 566546000804 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 566546000805 putative active site [active] 566546000806 catalytic triad [active] 566546000807 dimer interface [polypeptide binding]; other site 566546000808 multimer interface [polypeptide binding]; other site 566546000809 C-lysozyme inhibitor; Provisional; Region: PRK09993 566546000810 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 566546000811 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 566546000812 active site 566546000813 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 566546000814 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 566546000815 dimer interface [polypeptide binding]; other site 566546000816 active site 566546000817 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 566546000818 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 566546000819 putative active site [active] 566546000820 putative dimer interface [polypeptide binding]; other site 566546000821 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 566546000822 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 566546000823 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 566546000824 RelB antitoxin; Region: RelB; cl01171 566546000825 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 566546000826 NlpC/P60 family; Region: NLPC_P60; pfam00877 566546000827 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 566546000828 HicB family; Region: HicB; pfam05534 566546000829 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 566546000830 FHIPEP family; Region: FHIPEP; pfam00771 566546000831 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 566546000832 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 566546000833 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 566546000834 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 566546000835 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 566546000836 flagellar motor switch protein FliN; Region: fliN; TIGR02480 566546000837 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 566546000838 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 566546000839 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546000840 Walker A motif; other site 566546000841 ATP binding site [chemical binding]; other site 566546000842 Walker B motif; other site 566546000843 arginine finger; other site 566546000844 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 566546000845 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 566546000846 flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193 566546000847 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 566546000848 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 566546000849 flagellar motor switch protein G; Reviewed; Region: fliG; PRK07194 566546000850 MgtE intracellular N domain; Region: MgtE_N; smart00924 566546000851 FliG C-terminal domain; Region: FliG_C; pfam01706 566546000852 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 566546000853 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 566546000854 Flagellar assembly protein FliH; Region: FliH; pfam02108 566546000855 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07196 566546000856 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 566546000857 Walker A motif/ATP binding site; other site 566546000858 Walker B motif; other site 566546000859 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 566546000860 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 566546000861 active site 566546000862 nucleotide binding site [chemical binding]; other site 566546000863 HIGH motif; other site 566546000864 KMSKS motif; other site 566546000865 Mu-like prophage protein Com; Region: Mu-like_Com; cl11540 566546000866 multiple promoter invertase; Provisional; Region: mpi; PRK13413 566546000867 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 566546000868 catalytic residues [active] 566546000869 catalytic nucleophile [active] 566546000870 Presynaptic Site I dimer interface [polypeptide binding]; other site 566546000871 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 566546000872 Synaptic Flat tetramer interface [polypeptide binding]; other site 566546000873 Synaptic Site I dimer interface [polypeptide binding]; other site 566546000874 DNA binding site [nucleotide binding] 566546000875 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 566546000876 DNA-binding interface [nucleotide binding]; DNA binding site 566546000877 long tail fiber, proximal subunit; Provisional; Region: 34; PHA02584 566546000878 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 566546000879 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 566546000880 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 566546000881 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 566546000882 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 566546000883 Phage protein GP46; Region: GP46; pfam07409 566546000884 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 566546000885 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; pfam06890 566546000886 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 566546000887 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 566546000888 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 566546000889 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 566546000890 Mu-like prophage protein [General function prediction only]; Region: COG3941 566546000891 tape measure domain; Region: tape_meas_nterm; TIGR02675 566546000892 Mu-like prophage FluMu protein gp41 [Function unknown]; Region: COG4518 566546000893 Phage tail tube protein; Region: Tail_tube; pfam10618 566546000894 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 566546000895 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 566546000896 Protein of unknown function (DUF2635); Region: DUF2635; pfam10948 566546000897 Domain of unknown function (DUF1834); Region: DUF1834; pfam08873 566546000898 Protein of unknown function (DUF1320); Region: DUF1320; pfam07030 566546000899 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; pfam10124 566546000900 Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123 566546000901 phage virion morphogenesis (putative tail completion) protein; Region: tail_comp_S; TIGR01635 566546000902 Uncharacterized protein, homolog of phage Mu protein gp30 [Function unknown]; Region: COG2369 566546000903 Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233 566546000904 Protein of unknown function (DUF935); Region: DUF935; pfam06074 566546000905 Mu-like prophage protein gp29 [Function unknown]; Region: COG4383 566546000906 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 566546000907 Protein of unknown function (DUF3486); Region: DUF3486; pfam11985 566546000908 Protein of unknown function (DUF2730); Region: DUF2730; pfam10805 566546000909 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 566546000910 catalytic residues [active] 566546000911 Mor transcription activator family; Region: Mor; pfam08765 566546000912 Mor transcription activator family; Region: Mor; pfam08765 566546000913 Protein of unknown function (DUF1018); Region: DUF1018; pfam06252 566546000914 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 566546000915 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825 566546000916 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 566546000917 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 566546000918 Walker A motif; other site 566546000919 ATP binding site [chemical binding]; other site 566546000920 Walker B motif; other site 566546000921 Mu B transposition protein, C terminal; Region: Phage-MuB_C; pfam09077 566546000922 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 566546000923 Mu DNA binding, I gamma subdomain; Region: HTH_Tnp_Mu_2; pfam09039 566546000924 Bacteriophage Mu transposase; Region: DDE_2; pfam02914 566546000925 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 566546000926 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 566546000927 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 566546000928 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 566546000929 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 566546000930 active site 566546000931 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 566546000932 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 566546000933 FlgN protein; Region: FlgN; pfam05130 566546000934 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 566546000935 SAF-like; Region: SAF_2; pfam13144 566546000936 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 566546000937 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 566546000938 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 566546000939 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK12685 566546000940 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK06802 566546000941 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 566546000942 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 566546000943 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 566546000944 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 566546000945 flagellar hook protein FlgE; Validated; Region: flgE; PRK06803 566546000946 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 566546000947 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 566546000948 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 566546000949 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 566546000950 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 566546000951 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 566546000952 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 566546000953 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 566546000954 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12407 566546000955 Flagellar L-ring protein; Region: FlgH; pfam02107 566546000956 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 566546000957 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 566546000958 Rod binding protein; Region: Rod-binding; cl01626 566546000959 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191 566546000960 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 566546000961 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192 566546000962 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 566546000963 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 566546000964 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 566546000965 DNA binding site [nucleotide binding] 566546000966 flagellin; Reviewed; Region: PRK08869 566546000967 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 566546000968 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 566546000969 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 566546000970 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 566546000971 Flagellar protein FliS; Region: FliS; cl00654 566546000972 adenylate kinase; Region: PLN02674 566546000973 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 566546000974 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 566546000975 flagellar biosynthesis sigma factor; Provisional; Region: PRK12427 566546000976 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 566546000977 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 566546000978 DNA binding residues [nucleotide binding] 566546000979 flagellar motor protein MotA; Provisional; Region: PRK12482 566546000980 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 566546000981 pseudogene, protein that enables flagellar motor rotation 566546000982 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 566546000983 active site 566546000984 DNA polymerase IV; Validated; Region: PRK02406 566546000985 DNA binding site [nucleotide binding] 566546000986 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 566546000987 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 566546000988 Coenzyme A binding pocket [chemical binding]; other site 566546000989 hypothetical protein; Reviewed; Region: PRK09588 566546000990 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 566546000991 pseudogene, peptide chain release factor-like protein 566546000992 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 566546000993 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 566546000994 metal binding site [ion binding]; metal-binding site 566546000995 dimer interface [polypeptide binding]; other site 566546000996 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 566546000997 active site 566546000998 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 566546000999 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 566546001000 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 566546001001 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 566546001002 trimer interface [polypeptide binding]; other site 566546001003 eyelet of channel; other site 566546001004 gamma-glutamyl kinase; Provisional; Region: PRK05429 566546001005 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 566546001006 nucleotide binding site [chemical binding]; other site 566546001007 homotetrameric interface [polypeptide binding]; other site 566546001008 putative phosphate binding site [ion binding]; other site 566546001009 putative allosteric binding site; other site 566546001010 PUA domain; Region: PUA; pfam01472 566546001011 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 566546001012 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 566546001013 putative catalytic cysteine [active] 566546001014 pseudogene, predicted transcriptional regulator 566546001015 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 566546001016 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 566546001017 XdhC Rossmann domain; Region: XdhC_C; pfam13478 566546001018 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 566546001019 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 566546001020 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 566546001021 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 566546001022 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 566546001023 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 566546001024 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 566546001025 catalytic loop [active] 566546001026 iron binding site [ion binding]; other site 566546001027 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 566546001028 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 566546001029 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 566546001030 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 566546001031 putative fimbrial protein TcfA; Provisional; Region: PRK15308 566546001032 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 566546001033 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 566546001034 DNA binding residues [nucleotide binding] 566546001035 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 566546001036 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 566546001037 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 566546001038 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 566546001039 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 566546001040 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 566546001041 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 566546001042 pseudogene, DNA-binding transcriptional activator 566546001043 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 566546001044 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 566546001045 active site 566546001046 catalytic tetrad [active] 566546001047 Predicted membrane protein [Function unknown]; Region: COG3059 566546001048 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 566546001049 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 566546001050 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 566546001051 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 566546001052 Cupin; Region: Cupin_6; pfam12852 566546001053 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 566546001054 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546001055 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 566546001056 Cysteine-rich domain; Region: CCG; pfam02754 566546001057 Cysteine-rich domain; Region: CCG; pfam02754 566546001058 iron-sulfur cluster-binding protein; Region: TIGR00273 566546001059 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 566546001060 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 566546001061 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 566546001062 Uncharacterized conserved protein [Function unknown]; Region: COG1556 566546001063 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 566546001064 choline dehydrogenase; Validated; Region: PRK02106 566546001065 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 566546001066 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 566546001067 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 566546001068 tetrameric interface [polypeptide binding]; other site 566546001069 NAD binding site [chemical binding]; other site 566546001070 catalytic residues [active] 566546001071 transcriptional regulator BetI; Validated; Region: PRK00767 566546001072 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 566546001073 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 566546001074 choline transport protein BetT; Provisional; Region: PRK09928 566546001075 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 566546001076 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 566546001077 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 566546001078 Autotransporter beta-domain; Region: Autotransporter; pfam03797 566546001079 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 566546001080 DNA binding residues [nucleotide binding] 566546001081 dimerization interface [polypeptide binding]; other site 566546001082 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 566546001083 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 566546001084 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546001085 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 566546001086 dimerization interface [polypeptide binding]; other site 566546001087 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 566546001088 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 566546001089 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 566546001090 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 566546001091 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 566546001092 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 566546001093 CoA binding domain; Region: CoA_binding; pfam02629 566546001094 CoA-ligase; Region: Ligase_CoA; pfam00549 566546001095 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 566546001096 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 566546001097 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 566546001098 putative substrate binding site [chemical binding]; other site 566546001099 nucleotide binding site [chemical binding]; other site 566546001100 nucleotide binding site [chemical binding]; other site 566546001101 homodimer interface [polypeptide binding]; other site 566546001102 putative deaminase; Validated; Region: PRK06846 566546001103 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 566546001104 active site 566546001105 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 566546001106 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 566546001107 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 566546001108 ligand binding site [chemical binding]; other site 566546001109 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 566546001110 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 566546001111 Walker A/P-loop; other site 566546001112 ATP binding site [chemical binding]; other site 566546001113 Q-loop/lid; other site 566546001114 ABC transporter signature motif; other site 566546001115 Walker B; other site 566546001116 D-loop; other site 566546001117 H-loop/switch region; other site 566546001118 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 566546001119 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 566546001120 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 566546001121 TM-ABC transporter signature motif; other site 566546001122 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 566546001123 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 566546001124 TM-ABC transporter signature motif; other site 566546001125 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 566546001126 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 566546001127 putative NAD(P) binding site [chemical binding]; other site 566546001128 putative substrate binding site [chemical binding]; other site 566546001129 catalytic Zn binding site [ion binding]; other site 566546001130 structural Zn binding site [ion binding]; other site 566546001131 dimer interface [polypeptide binding]; other site 566546001132 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 566546001133 hypothetical protein; Provisional; Region: PRK09929 566546001134 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 566546001135 Propionate catabolism activator; Region: PrpR_N; pfam06506 566546001136 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546001137 Walker A motif; other site 566546001138 ATP binding site [chemical binding]; other site 566546001139 Walker B motif; other site 566546001140 arginine finger; other site 566546001141 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 566546001142 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 566546001143 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 566546001144 tetramer interface [polypeptide binding]; other site 566546001145 active site 566546001146 Mg2+/Mn2+ binding site [ion binding]; other site 566546001147 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 566546001148 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 566546001149 dimer interface [polypeptide binding]; other site 566546001150 active site 566546001151 citrylCoA binding site [chemical binding]; other site 566546001152 oxalacetate/citrate binding site [chemical binding]; other site 566546001153 coenzyme A binding site [chemical binding]; other site 566546001154 catalytic triad [active] 566546001155 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 566546001156 2-methylcitrate dehydratase; Region: prpD; TIGR02330 566546001157 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 566546001158 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 566546001159 acyl-activating enzyme (AAE) consensus motif; other site 566546001160 putative AMP binding site [chemical binding]; other site 566546001161 putative active site [active] 566546001162 putative CoA binding site [chemical binding]; other site 566546001163 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 566546001164 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 566546001165 Na binding site [ion binding]; other site 566546001166 putative substrate binding site [chemical binding]; other site 566546001167 cytosine deaminase; Provisional; Region: PRK09230 566546001168 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 566546001169 active site 566546001170 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 566546001171 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546001172 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 566546001173 dimerization interface [polypeptide binding]; other site 566546001174 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 566546001175 active site clefts [active] 566546001176 zinc binding site [ion binding]; other site 566546001177 dimer interface [polypeptide binding]; other site 566546001178 Cyanate lyase [Inorganic ion transport and metabolism]; Region: CynS; COG1513 566546001179 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 566546001180 oligomer interface [polypeptide binding]; other site 566546001181 active site 566546001182 putative cyanate transporter; Provisional; Region: cynX; PRK09705 566546001183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546001184 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 566546001185 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 566546001186 active site 566546001187 substrate binding site [chemical binding]; other site 566546001188 trimer interface [polypeptide binding]; other site 566546001189 CoA binding site [chemical binding]; other site 566546001190 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 566546001191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546001192 putative substrate translocation pore; other site 566546001193 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 566546001194 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 566546001195 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 566546001196 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 566546001197 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 566546001198 lac repressor; Reviewed; Region: lacI; PRK09526 566546001199 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 566546001200 DNA binding site [nucleotide binding] 566546001201 domain linker motif; other site 566546001202 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 566546001203 ligand binding site [chemical binding]; other site 566546001204 dimerization interface (open form) [polypeptide binding]; other site 566546001205 dimerization interface (closed form) [polypeptide binding]; other site 566546001206 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 566546001207 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 566546001208 Bacterial transcriptional regulator; Region: IclR; pfam01614 566546001209 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 566546001210 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 566546001211 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 566546001212 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 566546001213 putative active site [active] 566546001214 Fe(II) binding site [ion binding]; other site 566546001215 putative dimer interface [polypeptide binding]; other site 566546001216 putative tetramer interface [polypeptide binding]; other site 566546001217 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 566546001218 2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342 566546001219 acetaldehyde dehydrogenase; Validated; Region: PRK08300 566546001220 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 566546001221 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 566546001222 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 566546001223 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 566546001224 active site 566546001225 catalytic residues [active] 566546001226 metal binding site [ion binding]; metal-binding site 566546001227 DmpG-like communication domain; Region: DmpG_comm; pfam07836 566546001228 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 566546001229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546001230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546001231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 566546001232 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 566546001233 S-formylglutathione hydrolase; Region: PLN02442 566546001234 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 566546001235 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 566546001236 substrate binding site [chemical binding]; other site 566546001237 catalytic Zn binding site [ion binding]; other site 566546001238 NAD binding site [chemical binding]; other site 566546001239 structural Zn binding site [ion binding]; other site 566546001240 dimer interface [polypeptide binding]; other site 566546001241 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 566546001242 putative metal binding site [ion binding]; other site 566546001243 putative homodimer interface [polypeptide binding]; other site 566546001244 putative homotetramer interface [polypeptide binding]; other site 566546001245 putative homodimer-homodimer interface [polypeptide binding]; other site 566546001246 putative allosteric switch controlling residues; other site 566546001247 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 566546001248 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 566546001249 DXD motif; other site 566546001250 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 566546001251 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 566546001252 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 566546001253 substrate binding pocket [chemical binding]; other site 566546001254 membrane-bound complex binding site; other site 566546001255 hinge residues; other site 566546001256 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 566546001257 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 566546001258 Walker A/P-loop; other site 566546001259 ATP binding site [chemical binding]; other site 566546001260 Q-loop/lid; other site 566546001261 ABC transporter signature motif; other site 566546001262 Walker B; other site 566546001263 D-loop; other site 566546001264 H-loop/switch region; other site 566546001265 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 566546001266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546001267 dimer interface [polypeptide binding]; other site 566546001268 conserved gate region; other site 566546001269 putative PBP binding loops; other site 566546001270 ABC-ATPase subunit interface; other site 566546001271 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 566546001272 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 566546001273 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 566546001274 dimer interface [polypeptide binding]; other site 566546001275 active site 566546001276 Schiff base residues; other site 566546001277 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 566546001278 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 566546001279 Autotransporter beta-domain; Region: Autotransporter; pfam03797 566546001280 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 566546001281 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 566546001282 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 566546001283 microcin B17 transporter; Reviewed; Region: PRK11098 566546001284 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 566546001285 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 566546001286 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 566546001287 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 566546001288 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 566546001289 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 566546001290 anti-RssB factor; Provisional; Region: PRK10244 566546001291 alkaline phosphatase; Provisional; Region: PRK10518 566546001292 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 566546001293 dimer interface [polypeptide binding]; other site 566546001294 active site 566546001295 hypothetical protein; Provisional; Region: PRK11505 566546001296 psiF repeat; Region: PsiF_repeat; pfam07769 566546001297 psiF repeat; Region: PsiF_repeat; pfam07769 566546001298 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 566546001299 MASE2 domain; Region: MASE2; pfam05230 566546001300 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 566546001301 metal binding site [ion binding]; metal-binding site 566546001302 active site 566546001303 I-site; other site 566546001304 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 566546001305 pyrroline-5-carboxylate reductase; Region: PLN02688 566546001306 hypothetical protein; Validated; Region: PRK00124 566546001307 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 566546001308 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 566546001309 ADP binding site [chemical binding]; other site 566546001310 magnesium binding site [ion binding]; other site 566546001311 putative shikimate binding site; other site 566546001312 hypothetical protein; Provisional; Region: PRK10380 566546001313 hypothetical protein; Provisional; Region: PRK10481 566546001314 hypothetical protein; Provisional; Region: PRK10579 566546001315 pseudogene, hypothetical protein 566546001316 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 566546001317 fructokinase; Reviewed; Region: PRK09557 566546001318 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 566546001319 nucleotide binding site [chemical binding]; other site 566546001320 MFS transport protein AraJ; Provisional; Region: PRK10091 566546001321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546001322 putative substrate translocation pore; other site 566546001323 exonuclease subunit SbcC; Provisional; Region: PRK10246 566546001324 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 566546001325 Walker A/P-loop; other site 566546001326 ATP binding site [chemical binding]; other site 566546001327 Q-loop/lid; other site 566546001328 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 566546001329 ABC transporter signature motif; other site 566546001330 Walker B; other site 566546001331 D-loop; other site 566546001332 H-loop/switch region; other site 566546001333 exonuclease subunit SbcD; Provisional; Region: PRK10966 566546001334 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 566546001335 active site 566546001336 metal binding site [ion binding]; metal-binding site 566546001337 DNA binding site [nucleotide binding] 566546001338 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 566546001339 transcriptional regulator PhoB; Provisional; Region: PRK10161 566546001340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546001341 active site 566546001342 phosphorylation site [posttranslational modification] 566546001343 intermolecular recognition site; other site 566546001344 dimerization interface [polypeptide binding]; other site 566546001345 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 566546001346 DNA binding site [nucleotide binding] 566546001347 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 566546001348 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 566546001349 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 566546001350 putative active site [active] 566546001351 heme pocket [chemical binding]; other site 566546001352 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 566546001353 dimer interface [polypeptide binding]; other site 566546001354 phosphorylation site [posttranslational modification] 566546001355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546001356 ATP binding site [chemical binding]; other site 566546001357 Mg2+ binding site [ion binding]; other site 566546001358 G-X-G motif; other site 566546001359 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 566546001360 putative proline-specific permease; Provisional; Region: proY; PRK10580 566546001361 Spore germination protein; Region: Spore_permease; cl17796 566546001362 maltodextrin glucosidase; Provisional; Region: PRK10785 566546001363 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 566546001364 homodimer interface [polypeptide binding]; other site 566546001365 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 566546001366 active site 566546001367 homodimer interface [polypeptide binding]; other site 566546001368 catalytic site [active] 566546001369 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 566546001370 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 566546001371 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 566546001372 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 566546001373 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 566546001374 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 566546001375 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 566546001376 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 566546001377 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 566546001378 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 566546001379 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 566546001380 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 566546001381 Protein export membrane protein; Region: SecD_SecF; pfam02355 566546001382 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 566546001383 active site 566546001384 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 566546001385 hypothetical protein; Provisional; Region: PRK11530 566546001386 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 566546001387 ATP cone domain; Region: ATP-cone; pfam03477 566546001388 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 566546001389 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 566546001390 catalytic motif [active] 566546001391 Zn binding site [ion binding]; other site 566546001392 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 566546001393 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 566546001394 homopentamer interface [polypeptide binding]; other site 566546001395 active site 566546001396 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 566546001397 putative RNA binding site [nucleotide binding]; other site 566546001398 thiamine monophosphate kinase; Provisional; Region: PRK05731 566546001399 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 566546001400 ATP binding site [chemical binding]; other site 566546001401 dimerization interface [polypeptide binding]; other site 566546001402 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 566546001403 tetramer interfaces [polypeptide binding]; other site 566546001404 binuclear metal-binding site [ion binding]; other site 566546001405 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 566546001406 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 566546001407 active site 566546001408 catalytic tetrad [active] 566546001409 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 566546001410 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 566546001411 TPP-binding site; other site 566546001412 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 566546001413 PYR/PP interface [polypeptide binding]; other site 566546001414 dimer interface [polypeptide binding]; other site 566546001415 TPP binding site [chemical binding]; other site 566546001416 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 566546001417 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 566546001418 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 566546001419 substrate binding pocket [chemical binding]; other site 566546001420 chain length determination region; other site 566546001421 substrate-Mg2+ binding site; other site 566546001422 catalytic residues [active] 566546001423 aspartate-rich region 1; other site 566546001424 active site lid residues [active] 566546001425 aspartate-rich region 2; other site 566546001426 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 566546001427 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 566546001428 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 566546001429 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 566546001430 Ligand Binding Site [chemical binding]; other site 566546001431 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 566546001432 active site residue [active] 566546001433 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 566546001434 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 566546001435 conserved cys residue [active] 566546001436 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 566546001437 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 566546001438 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 566546001439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 566546001440 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 566546001441 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546001442 Major Facilitator Superfamily; Region: MFS_1; pfam07690 566546001443 putative substrate translocation pore; other site 566546001444 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 566546001445 Sel1 repeat; Region: Sel1; pfam08238 566546001446 Sel1-like repeats; Region: SEL1; smart00671 566546001447 Sel1-like repeats; Region: SEL1; smart00671 566546001448 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 566546001449 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 566546001450 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 566546001451 UbiA prenyltransferase family; Region: UbiA; pfam01040 566546001452 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 566546001453 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 566546001454 Subunit I/III interface [polypeptide binding]; other site 566546001455 Subunit III/IV interface [polypeptide binding]; other site 566546001456 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 566546001457 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 566546001458 D-pathway; other site 566546001459 Putative ubiquinol binding site [chemical binding]; other site 566546001460 Low-spin heme (heme b) binding site [chemical binding]; other site 566546001461 Putative water exit pathway; other site 566546001462 Binuclear center (heme o3/CuB) [ion binding]; other site 566546001463 K-pathway; other site 566546001464 Putative proton exit pathway; other site 566546001465 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 566546001466 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 566546001467 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 566546001468 muropeptide transporter; Reviewed; Region: ampG; PRK11902 566546001469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546001470 putative substrate translocation pore; other site 566546001471 hypothetical protein; Provisional; Region: PRK11627 566546001472 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 566546001473 transcriptional regulator BolA; Provisional; Region: PRK11628 566546001474 trigger factor; Provisional; Region: tig; PRK01490 566546001475 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 566546001476 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 566546001477 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 566546001478 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 566546001479 oligomer interface [polypeptide binding]; other site 566546001480 active site residues [active] 566546001481 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 566546001482 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 566546001483 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546001484 Walker A motif; other site 566546001485 ATP binding site [chemical binding]; other site 566546001486 Walker B motif; other site 566546001487 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 566546001488 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 566546001489 Found in ATP-dependent protease La (LON); Region: LON; smart00464 566546001490 Found in ATP-dependent protease La (LON); Region: LON; smart00464 566546001491 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546001492 Walker A motif; other site 566546001493 ATP binding site [chemical binding]; other site 566546001494 Walker B motif; other site 566546001495 arginine finger; other site 566546001496 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 566546001497 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 566546001498 IHF dimer interface [polypeptide binding]; other site 566546001499 IHF - DNA interface [nucleotide binding]; other site 566546001500 periplasmic folding chaperone; Provisional; Region: PRK10788 566546001501 SurA N-terminal domain; Region: SurA_N_3; cl07813 566546001502 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 566546001503 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 566546001504 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 566546001505 active site 566546001506 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 566546001507 Ligand Binding Site [chemical binding]; other site 566546001508 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 566546001509 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 566546001510 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 566546001511 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 566546001512 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 566546001513 active site 566546001514 motif I; other site 566546001515 motif II; other site 566546001516 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 566546001517 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 566546001518 putative DNA binding site [nucleotide binding]; other site 566546001519 putative Zn2+ binding site [ion binding]; other site 566546001520 AsnC family; Region: AsnC_trans_reg; pfam01037 566546001521 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 566546001522 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 566546001523 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 566546001524 Walker A/P-loop; other site 566546001525 ATP binding site [chemical binding]; other site 566546001526 Q-loop/lid; other site 566546001527 ABC transporter signature motif; other site 566546001528 Walker B; other site 566546001529 D-loop; other site 566546001530 H-loop/switch region; other site 566546001531 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 566546001532 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 566546001533 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 566546001534 Walker A/P-loop; other site 566546001535 ATP binding site [chemical binding]; other site 566546001536 Q-loop/lid; other site 566546001537 ABC transporter signature motif; other site 566546001538 Walker B; other site 566546001539 D-loop; other site 566546001540 H-loop/switch region; other site 566546001541 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 566546001542 Nitrogen regulatory protein P-II; Region: P-II; smart00938 566546001543 ammonium transporter; Provisional; Region: PRK10666 566546001544 acyl-CoA thioesterase II; Provisional; Region: PRK10526 566546001545 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 566546001546 active site 566546001547 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 566546001548 catalytic triad [active] 566546001549 dimer interface [polypeptide binding]; other site 566546001550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 566546001551 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 566546001552 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 566546001553 DNA binding site [nucleotide binding] 566546001554 active site 566546001555 Uncharacterized conserved protein [Function unknown]; Region: COG5507 566546001556 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 566546001557 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 566546001558 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 566546001559 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 566546001560 maltose O-acetyltransferase; Provisional; Region: PRK10092 566546001561 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 566546001562 active site 566546001563 substrate binding site [chemical binding]; other site 566546001564 trimer interface [polypeptide binding]; other site 566546001565 CoA binding site [chemical binding]; other site 566546001566 gene expression modulator; Provisional; Region: PRK10945 566546001567 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 566546001568 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 566546001569 Protein export membrane protein; Region: SecD_SecF; cl14618 566546001570 Protein export membrane protein; Region: SecD_SecF; cl14618 566546001571 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 566546001572 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 566546001573 HlyD family secretion protein; Region: HlyD_3; pfam13437 566546001574 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 566546001575 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 566546001576 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 566546001577 hypothetical protein; Provisional; Region: PRK11281 566546001578 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 566546001579 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 566546001580 Mechanosensitive ion channel; Region: MS_channel; pfam00924 566546001581 hypothetical protein; Provisional; Region: PRK11038 566546001582 primosomal replication protein N''; Provisional; Region: PRK10093 566546001583 hypothetical protein; Provisional; Region: PRK10527 566546001584 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 566546001585 active site 566546001586 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 566546001587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546001588 Walker A motif; other site 566546001589 ATP binding site [chemical binding]; other site 566546001590 Walker B motif; other site 566546001591 DNA polymerase III subunit delta'; Validated; Region: PRK08485 566546001592 arginine finger; other site 566546001593 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 566546001594 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 566546001595 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 566546001596 hypothetical protein; Validated; Region: PRK00153 566546001597 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 566546001598 RecR protein; Region: RecR; pfam02132 566546001599 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 566546001600 putative active site [active] 566546001601 putative metal-binding site [ion binding]; other site 566546001602 tetramer interface [polypeptide binding]; other site 566546001603 heat shock protein 90; Provisional; Region: PRK05218 566546001604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546001605 ATP binding site [chemical binding]; other site 566546001606 Mg2+ binding site [ion binding]; other site 566546001607 G-X-G motif; other site 566546001608 adenylate kinase; Reviewed; Region: adk; PRK00279 566546001609 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 566546001610 AMP-binding site [chemical binding]; other site 566546001611 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 566546001612 ferrochelatase; Region: hemH; TIGR00109 566546001613 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 566546001614 C-terminal domain interface [polypeptide binding]; other site 566546001615 active site 566546001616 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 566546001617 active site 566546001618 N-terminal domain interface [polypeptide binding]; other site 566546001619 acetyl esterase; Provisional; Region: PRK10162 566546001620 inosine/guanosine kinase; Provisional; Region: PRK15074 566546001621 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 566546001622 putative cation:proton antiport protein; Provisional; Region: PRK10669 566546001623 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 566546001624 TrkA-N domain; Region: TrkA_N; pfam02254 566546001625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546001626 Major Facilitator Superfamily; Region: MFS_1; pfam07690 566546001627 putative substrate translocation pore; other site 566546001628 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 566546001629 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 566546001630 active site 566546001631 metal binding site [ion binding]; metal-binding site 566546001632 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 566546001633 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 566546001634 putative deacylase active site [active] 566546001635 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 566546001636 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 566546001637 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 566546001638 non-specific DNA binding site [nucleotide binding]; other site 566546001639 salt bridge; other site 566546001640 sequence-specific DNA binding site [nucleotide binding]; other site 566546001641 copper exporting ATPase; Provisional; Region: copA; PRK10671 566546001642 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 566546001643 metal-binding site [ion binding] 566546001644 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 566546001645 metal-binding site [ion binding] 566546001646 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 566546001647 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 566546001648 motif II; other site 566546001649 glutaminase; Reviewed; Region: PRK12356 566546001650 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 566546001651 amino acid transporter; Region: 2A0306; TIGR00909 566546001652 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 566546001653 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 566546001654 DNA binding residues [nucleotide binding] 566546001655 dimer interface [polypeptide binding]; other site 566546001656 copper binding site [ion binding]; other site 566546001657 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 566546001658 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 566546001659 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 566546001660 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 566546001661 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 566546001662 Walker A/P-loop; other site 566546001663 ATP binding site [chemical binding]; other site 566546001664 Q-loop/lid; other site 566546001665 ABC transporter signature motif; other site 566546001666 Walker B; other site 566546001667 D-loop; other site 566546001668 H-loop/switch region; other site 566546001669 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 566546001670 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 566546001671 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 566546001672 oxidoreductase; Provisional; Region: PRK08017 566546001673 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 566546001674 NADP binding site [chemical binding]; other site 566546001675 active site 566546001676 steroid binding site; other site 566546001677 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 566546001678 active site 566546001679 catalytic triad [active] 566546001680 oxyanion hole [active] 566546001681 switch loop; other site 566546001682 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 566546001683 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 566546001684 Walker A/P-loop; other site 566546001685 ATP binding site [chemical binding]; other site 566546001686 Q-loop/lid; other site 566546001687 ABC transporter signature motif; other site 566546001688 Walker B; other site 566546001689 D-loop; other site 566546001690 H-loop/switch region; other site 566546001691 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 566546001692 FtsX-like permease family; Region: FtsX; pfam02687 566546001693 FtsX-like permease family; Region: FtsX; pfam02687 566546001694 pseudogene, Type I RHS protein fragment 566546001695 pseudogene, putative rhs C-terminal tip 566546001696 pseudogene, hypothetical protein 566546001697 Winged helix-turn helix; Region: HTH_29; pfam13551 566546001698 Helix-turn-helix domain; Region: HTH_28; pfam13518 566546001699 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 566546001700 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 566546001701 active site residue [active] 566546001702 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 566546001703 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546001704 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 566546001705 dimerization interface [polypeptide binding]; other site 566546001706 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 566546001707 ureidoglycolate hydrolase; Provisional; Region: PRK03606 566546001708 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 566546001709 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 566546001710 Bacterial transcriptional regulator; Region: IclR; pfam01614 566546001711 glyoxylate carboligase; Provisional; Region: PRK11269 566546001712 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 566546001713 PYR/PP interface [polypeptide binding]; other site 566546001714 dimer interface [polypeptide binding]; other site 566546001715 TPP binding site [chemical binding]; other site 566546001716 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 566546001717 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 566546001718 TPP-binding site [chemical binding]; other site 566546001719 hydroxypyruvate isomerase; Provisional; Region: PRK09997 566546001720 tartronate semialdehyde reductase; Provisional; Region: PRK15059 566546001721 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 566546001722 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 566546001723 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 566546001724 Na binding site [ion binding]; other site 566546001725 substrate binding site [chemical binding]; other site 566546001726 allantoinase; Provisional; Region: PRK08044 566546001727 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 566546001728 active site 566546001729 putative uracil/xanthine transporter; Provisional; Region: PRK11412 566546001730 glycerate kinase II; Provisional; Region: PRK09932 566546001731 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 566546001732 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 566546001733 Cupin domain; Region: Cupin_2; cl17218 566546001734 allantoate amidohydrolase; Region: AllC; TIGR03176 566546001735 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 566546001736 active site 566546001737 metal binding site [ion binding]; metal-binding site 566546001738 dimer interface [polypeptide binding]; other site 566546001739 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 566546001740 membrane protein FdrA; Validated; Region: PRK06091 566546001741 CoA binding domain; Region: CoA_binding; pfam02629 566546001742 CoA-ligase; Region: Ligase_CoA; pfam00549 566546001743 pseudogene, hypothetical protein 566546001744 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 566546001745 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 566546001746 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 566546001747 putative substrate binding site [chemical binding]; other site 566546001748 nucleotide binding site [chemical binding]; other site 566546001749 nucleotide binding site [chemical binding]; other site 566546001750 homodimer interface [polypeptide binding]; other site 566546001751 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 566546001752 ATP-grasp domain; Region: ATP-grasp; pfam02222 566546001753 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 566546001754 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 566546001755 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 566546001756 putative active site [active] 566546001757 putative metal binding site [ion binding]; other site 566546001758 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 566546001759 substrate binding site [chemical binding]; other site 566546001760 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 566546001761 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 566546001762 active site 566546001763 HIGH motif; other site 566546001764 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 566546001765 KMSKS motif; other site 566546001766 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 566546001767 tRNA binding surface [nucleotide binding]; other site 566546001768 anticodon binding site; other site 566546001769 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 566546001770 ribosome-associated protein; Provisional; Region: PRK11507 566546001771 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 566546001772 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 566546001773 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 566546001774 homodimer interface [polypeptide binding]; other site 566546001775 NADP binding site [chemical binding]; other site 566546001776 substrate binding site [chemical binding]; other site 566546001777 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 566546001778 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 566546001779 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 566546001780 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 566546001781 outer membrane usher protein FimD; Provisional; Region: PRK15198 566546001782 PapC N-terminal domain; Region: PapC_N; pfam13954 566546001783 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 566546001784 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 566546001785 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 566546001786 transcriptional regulator FimZ; Provisional; Region: PRK09935 566546001787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546001788 active site 566546001789 phosphorylation site [posttranslational modification] 566546001790 intermolecular recognition site; other site 566546001791 dimerization interface [polypeptide binding]; other site 566546001792 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 566546001793 DNA binding residues [nucleotide binding] 566546001794 dimerization interface [polypeptide binding]; other site 566546001795 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 566546001796 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546001797 hypothetical protein; Provisional; Region: PRK09936 566546001798 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 566546001799 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 566546001800 TPR motif; other site 566546001801 binding surface 566546001802 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 566546001803 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 566546001804 active site 566546001805 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 566546001806 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 566546001807 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 566546001808 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 566546001809 Transposase [DNA replication, recombination, and repair]; Region: COG5433 566546001810 Transposase [DNA replication, recombination, and repair]; Region: COG5433 566546001811 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 566546001812 RHS Repeat; Region: RHS_repeat; cl11982 566546001813 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 566546001814 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 566546001815 RHS Repeat; Region: RHS_repeat; cl11982 566546001816 RHS Repeat; Region: RHS_repeat; cl11982 566546001817 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 566546001818 PAAR motif; Region: PAAR_motif; pfam05488 566546001819 RHS Repeat; Region: RHS_repeat; cl11982 566546001820 RHS Repeat; Region: RHS_repeat; pfam05593 566546001821 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 566546001822 RHS Repeat; Region: RHS_repeat; pfam05593 566546001823 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 566546001824 RHS Repeat; Region: RHS_repeat; pfam05593 566546001825 RHS Repeat; Region: RHS_repeat; cl11982 566546001826 RHS Repeat; Region: RHS_repeat; pfam05593 566546001827 RHS Repeat; Region: RHS_repeat; cl11982 566546001828 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 566546001829 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 566546001830 Uncharacterized conserved protein [Function unknown]; Region: COG5435 566546001831 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 566546001832 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 566546001833 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 566546001834 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 566546001835 sensor kinase CusS; Provisional; Region: PRK09835 566546001836 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 566546001837 dimerization interface [polypeptide binding]; other site 566546001838 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 566546001839 dimer interface [polypeptide binding]; other site 566546001840 phosphorylation site [posttranslational modification] 566546001841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546001842 ATP binding site [chemical binding]; other site 566546001843 Mg2+ binding site [ion binding]; other site 566546001844 G-X-G motif; other site 566546001845 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 566546001846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546001847 active site 566546001848 phosphorylation site [posttranslational modification] 566546001849 intermolecular recognition site; other site 566546001850 dimerization interface [polypeptide binding]; other site 566546001851 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 566546001852 DNA binding site [nucleotide binding] 566546001853 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 566546001854 periplasmic copper-binding protein; Provisional; Region: PRK09838 566546001855 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 566546001856 HlyD family secretion protein; Region: HlyD_3; pfam13437 566546001857 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 566546001858 phenylalanine transporter; Provisional; Region: PRK10249 566546001859 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 566546001860 Mechanosensitive ion channel; Region: MS_channel; pfam00924 566546001861 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 566546001862 dimer interface [polypeptide binding]; other site 566546001863 FMN binding site [chemical binding]; other site 566546001864 hypothetical protein; Provisional; Region: PRK10250 566546001865 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 566546001866 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 566546001867 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 566546001868 Hok/gef family; Region: HOK_GEF; pfam01848 566546001869 Hok/gef family; Region: HOK_GEF; pfam01848 566546001870 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 566546001871 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 566546001872 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 566546001873 outer membrane receptor FepA; Provisional; Region: PRK13524 566546001874 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 566546001875 N-terminal plug; other site 566546001876 ligand-binding site [chemical binding]; other site 566546001877 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 566546001878 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 566546001879 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 566546001880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 566546001881 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 566546001882 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 566546001883 acyl-activating enzyme (AAE) consensus motif; other site 566546001884 AMP binding site [chemical binding]; other site 566546001885 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 566546001886 LPS O-antigen length regulator; Provisional; Region: PRK10381 566546001887 Chain length determinant protein; Region: Wzz; pfam02706 566546001888 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 566546001889 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 566546001890 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 566546001891 Walker A/P-loop; other site 566546001892 ATP binding site [chemical binding]; other site 566546001893 Q-loop/lid; other site 566546001894 ABC transporter signature motif; other site 566546001895 Walker B; other site 566546001896 D-loop; other site 566546001897 H-loop/switch region; other site 566546001898 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 566546001899 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 566546001900 ABC-ATPase subunit interface; other site 566546001901 dimer interface [polypeptide binding]; other site 566546001902 putative PBP binding regions; other site 566546001903 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 566546001904 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 566546001905 ABC-ATPase subunit interface; other site 566546001906 dimer interface [polypeptide binding]; other site 566546001907 putative PBP binding regions; other site 566546001908 enterobactin exporter EntS; Provisional; Region: PRK10489 566546001909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546001910 putative substrate translocation pore; other site 566546001911 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 566546001912 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 566546001913 siderophore binding site; other site 566546001914 isochorismate synthase EntC; Provisional; Region: PRK15016 566546001915 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 566546001916 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 566546001917 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 566546001918 acyl-activating enzyme (AAE) consensus motif; other site 566546001919 active site 566546001920 AMP binding site [chemical binding]; other site 566546001921 substrate binding site [chemical binding]; other site 566546001922 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 566546001923 hydrophobic substrate binding pocket; other site 566546001924 Isochorismatase family; Region: Isochorismatase; pfam00857 566546001925 active site 566546001926 conserved cis-peptide bond; other site 566546001927 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 566546001928 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 566546001929 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 566546001930 putative NAD(P) binding site [chemical binding]; other site 566546001931 active site 566546001932 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 566546001933 CoenzymeA binding site [chemical binding]; other site 566546001934 subunit interaction site [polypeptide binding]; other site 566546001935 PHB binding site; other site 566546001936 carbon starvation protein A; Provisional; Region: PRK15015 566546001937 Carbon starvation protein CstA; Region: CstA; pfam02554 566546001938 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 566546001939 Uncharacterized small protein [Function unknown]; Region: COG2879 566546001940 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 566546001941 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 566546001942 putative active site [active] 566546001943 metal binding site [ion binding]; metal-binding site 566546001944 methionine aminotransferase; Validated; Region: PRK09082 566546001945 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 566546001946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546001947 homodimer interface [polypeptide binding]; other site 566546001948 catalytic residue [active] 566546001949 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 566546001950 ParB-like nuclease domain; Region: ParBc; pfam02195 566546001951 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 566546001952 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 566546001953 Active Sites [active] 566546001954 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 566546001955 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 566546001956 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546001957 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 566546001958 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 566546001959 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 566546001960 dimerization domain [polypeptide binding]; other site 566546001961 dimer interface [polypeptide binding]; other site 566546001962 catalytic residues [active] 566546001963 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 566546001964 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 566546001965 dimer interface [polypeptide binding]; other site 566546001966 decamer (pentamer of dimers) interface [polypeptide binding]; other site 566546001967 catalytic triad [active] 566546001968 peroxidatic and resolving cysteines [active] 566546001969 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 566546001970 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 566546001971 catalytic residue [active] 566546001972 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 566546001973 catalytic residues [active] 566546001974 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 566546001975 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 566546001976 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 566546001977 Ligand Binding Site [chemical binding]; other site 566546001978 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 566546001979 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 566546001980 NAD binding site [chemical binding]; other site 566546001981 catalytic Zn binding site [ion binding]; other site 566546001982 structural Zn binding site [ion binding]; other site 566546001983 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 566546001984 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 566546001985 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 566546001986 B1 nucleotide binding pocket [chemical binding]; other site 566546001987 B2 nucleotide binding pocket [chemical binding]; other site 566546001988 CAS motifs; other site 566546001989 active site 566546001990 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 566546001991 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 566546001992 transmembrane helices; other site 566546001993 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 566546001994 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 566546001995 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 566546001996 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 566546001997 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 566546001998 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 566546001999 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 566546002000 putative active site [active] 566546002001 (T/H)XGH motif; other site 566546002002 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 566546002003 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 566546002004 putative active site [active] 566546002005 heme pocket [chemical binding]; other site 566546002006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546002007 ATP binding site [chemical binding]; other site 566546002008 Mg2+ binding site [ion binding]; other site 566546002009 G-X-G motif; other site 566546002010 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 566546002011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546002012 active site 566546002013 phosphorylation site [posttranslational modification] 566546002014 intermolecular recognition site; other site 566546002015 dimerization interface [polypeptide binding]; other site 566546002016 Transcriptional regulator; Region: CitT; pfam12431 566546002017 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 566546002018 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 566546002019 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 566546002020 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 566546002021 DNA-binding site [nucleotide binding]; DNA binding site 566546002022 RNA-binding motif; other site 566546002023 chromosome condensation membrane protein; Provisional; Region: PRK14196 566546002024 Predicted amidohydrolase [General function prediction only]; Region: COG0388 566546002025 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 566546002026 putative active site [active] 566546002027 catalytic triad [active] 566546002028 putative dimer interface [polypeptide binding]; other site 566546002029 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 566546002030 lipoyl synthase; Provisional; Region: PRK05481 566546002031 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 566546002032 FeS/SAM binding site; other site 566546002033 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 566546002034 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546002035 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 566546002036 substrate binding pocket [chemical binding]; other site 566546002037 dimerization interface [polypeptide binding]; other site 566546002038 lipoate-protein ligase B; Provisional; Region: PRK14342 566546002039 hypothetical protein; Provisional; Region: PRK04998 566546002040 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 566546002041 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 566546002042 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 566546002043 rare lipoprotein A; Provisional; Region: PRK10672 566546002044 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 566546002045 Sporulation related domain; Region: SPOR; pfam05036 566546002046 cell wall shape-determining protein; Provisional; Region: PRK10794 566546002047 penicillin-binding protein 2; Provisional; Region: PRK10795 566546002048 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 566546002049 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 566546002050 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 566546002051 ribosome-associated protein; Provisional; Region: PRK11538 566546002052 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 566546002053 catalytic core [active] 566546002054 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 566546002055 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 566546002056 active site 566546002057 (T/H)XGH motif; other site 566546002058 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 566546002059 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 566546002060 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 566546002061 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 566546002062 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 566546002063 HIGH motif; other site 566546002064 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 566546002065 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 566546002066 active site 566546002067 KMSKS motif; other site 566546002068 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 566546002069 tRNA binding surface [nucleotide binding]; other site 566546002070 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 566546002071 hypothetical protein; Provisional; Region: PRK11032 566546002072 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 566546002073 Sel1-like repeats; Region: SEL1; smart00671 566546002074 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 566546002075 Sel1-like repeats; Region: SEL1; smart00671 566546002076 Sel1-like repeats; Region: SEL1; smart00671 566546002077 Sel1-like repeats; Region: SEL1; smart00671 566546002078 Sel1-like repeats; Region: SEL1; smart00671 566546002079 Sel1-like repeats; Region: SEL1; smart00671 566546002080 Sel1-like repeats; Region: SEL1; smart00671 566546002081 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 566546002082 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 566546002083 HSP70 interaction site [polypeptide binding]; other site 566546002084 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 566546002085 Sel1-like repeats; Region: SEL1; smart00671 566546002086 Sel1-like repeats; Region: SEL1; smart00671 566546002087 Sel1-like repeats; Region: SEL1; smart00671 566546002088 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 566546002089 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 566546002090 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 566546002091 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 566546002092 nucleotide binding site [chemical binding]; other site 566546002093 putative NEF/HSP70 interaction site [polypeptide binding]; other site 566546002094 SBD interface [polypeptide binding]; other site 566546002095 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 566546002096 active site 566546002097 tetramer interface [polypeptide binding]; other site 566546002098 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 566546002099 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 566546002100 Walker A/P-loop; other site 566546002101 ATP binding site [chemical binding]; other site 566546002102 Q-loop/lid; other site 566546002103 ABC transporter signature motif; other site 566546002104 Walker B; other site 566546002105 D-loop; other site 566546002106 H-loop/switch region; other site 566546002107 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 566546002108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546002109 dimer interface [polypeptide binding]; other site 566546002110 conserved gate region; other site 566546002111 putative PBP binding loops; other site 566546002112 ABC-ATPase subunit interface; other site 566546002113 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 566546002114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546002115 dimer interface [polypeptide binding]; other site 566546002116 conserved gate region; other site 566546002117 putative PBP binding loops; other site 566546002118 ABC-ATPase subunit interface; other site 566546002119 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 566546002120 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 566546002121 substrate binding pocket [chemical binding]; other site 566546002122 membrane-bound complex binding site; other site 566546002123 hinge residues; other site 566546002124 pseudogene, hypothetical protein 566546002125 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 566546002126 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 566546002127 putative active site [active] 566546002128 catalytic triad [active] 566546002129 putative dimer interface [polypeptide binding]; other site 566546002130 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 566546002131 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 566546002132 Transporter associated domain; Region: CorC_HlyC; smart01091 566546002133 metal-binding heat shock protein; Provisional; Region: PRK00016 566546002134 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 566546002135 PhoH-like protein; Region: PhoH; pfam02562 566546002136 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 566546002137 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 566546002138 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 566546002139 FeS/SAM binding site; other site 566546002140 TRAM domain; Region: TRAM; pfam01938 566546002141 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 566546002142 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 566546002143 asparagine synthetase B; Provisional; Region: asnB; PRK09431 566546002144 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 566546002145 active site 566546002146 dimer interface [polypeptide binding]; other site 566546002147 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 566546002148 Ligand Binding Site [chemical binding]; other site 566546002149 Molecular Tunnel; other site 566546002150 UMP phosphatase; Provisional; Region: PRK10444 566546002151 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 566546002152 active site 566546002153 motif I; other site 566546002154 motif II; other site 566546002155 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 566546002156 MarR family; Region: MarR; pfam01047 566546002157 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 566546002158 ROK family; Region: ROK; pfam00480 566546002159 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 566546002160 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 566546002161 active site 566546002162 dimer interface [polypeptide binding]; other site 566546002163 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 566546002164 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 566546002165 active site 566546002166 trimer interface [polypeptide binding]; other site 566546002167 allosteric site; other site 566546002168 active site lid [active] 566546002169 hexamer (dimer of trimers) interface [polypeptide binding]; other site 566546002170 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 566546002171 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 566546002172 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 566546002173 active site turn [active] 566546002174 phosphorylation site [posttranslational modification] 566546002175 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 566546002176 HPr interaction site; other site 566546002177 glycerol kinase (GK) interaction site [polypeptide binding]; other site 566546002178 active site 566546002179 phosphorylation site [posttranslational modification] 566546002180 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 566546002181 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 566546002182 active site 566546002183 HIGH motif; other site 566546002184 nucleotide binding site [chemical binding]; other site 566546002185 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 566546002186 KMSKS motif; other site 566546002187 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 566546002188 outer membrane porin, OprD family; Region: OprD; pfam03573 566546002189 YbfN-like lipoprotein; Region: YbfN; pfam13982 566546002190 ferric uptake regulator; Provisional; Region: fur; PRK09462 566546002191 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 566546002192 metal binding site 2 [ion binding]; metal-binding site 566546002193 putative DNA binding helix; other site 566546002194 metal binding site 1 [ion binding]; metal-binding site 566546002195 dimer interface [polypeptide binding]; other site 566546002196 structural Zn2+ binding site [ion binding]; other site 566546002197 ryhB-regulated fur leader peptide; Provisional; Region: PRK14761 566546002198 flavodoxin FldA; Validated; Region: PRK09267 566546002199 LexA regulated protein; Provisional; Region: PRK11675 566546002200 acyl-CoA esterase; Provisional; Region: PRK10673 566546002201 PGAP1-like protein; Region: PGAP1; pfam07819 566546002202 replication initiation regulator SeqA; Provisional; Region: PRK11187 566546002203 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 566546002204 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 566546002205 active site 566546002206 substrate binding site [chemical binding]; other site 566546002207 metal binding site [ion binding]; metal-binding site 566546002208 putrescine transporter; Provisional; Region: potE; PRK10655 566546002209 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 566546002210 ornithine decarboxylase; Provisional; Region: PRK13578 566546002211 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 566546002212 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 566546002213 homodimer interface [polypeptide binding]; other site 566546002214 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546002215 catalytic residue [active] 566546002216 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 566546002217 Protein of unknown function (DUF2618); Region: DUF2618; pfam10940 566546002218 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 566546002219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546002220 active site 566546002221 phosphorylation site [posttranslational modification] 566546002222 intermolecular recognition site; other site 566546002223 dimerization interface [polypeptide binding]; other site 566546002224 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 566546002225 DNA binding site [nucleotide binding] 566546002226 sensor protein KdpD; Provisional; Region: PRK10490 566546002227 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 566546002228 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 566546002229 Ligand Binding Site [chemical binding]; other site 566546002230 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 566546002231 GAF domain; Region: GAF_3; pfam13492 566546002232 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 566546002233 dimer interface [polypeptide binding]; other site 566546002234 phosphorylation site [posttranslational modification] 566546002235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546002236 ATP binding site [chemical binding]; other site 566546002237 Mg2+ binding site [ion binding]; other site 566546002238 G-X-G motif; other site 566546002239 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 566546002240 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 566546002241 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 566546002242 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 566546002243 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 566546002244 pseudogene, Type I RHS protein fragment 566546002245 putative lyase; Provisional; Region: PRK09687 566546002246 pseudogene, putative rhs C-terminal tip 566546002247 pseudogene, putative rhs C-terminal tip 566546002248 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 566546002249 pseudogene, putative rhs C-terminal tip 566546002250 hypothetical protein; Provisional; Region: PRK10167 566546002251 Uncharacterized conserved protein [Function unknown]; Region: COG3272 566546002252 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 566546002253 DNA photolyase; Region: DNA_photolyase; pfam00875 566546002254 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 566546002255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546002256 putative substrate translocation pore; other site 566546002257 POT family; Region: PTR2; pfam00854 566546002258 Uncharacterized conserved protein [Function unknown]; Region: COG0327 566546002259 metal-binding protein; Provisional; Region: PRK10799 566546002260 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 566546002261 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 566546002262 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 566546002263 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 566546002264 putative active site [active] 566546002265 endonuclease VIII; Provisional; Region: PRK10445 566546002266 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 566546002267 DNA binding site [nucleotide binding] 566546002268 catalytic residue [active] 566546002269 putative catalytic residues [active] 566546002270 H2TH interface [polypeptide binding]; other site 566546002271 intercalation triad [nucleotide binding]; other site 566546002272 substrate specificity determining residue; other site 566546002273 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 566546002274 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 566546002275 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 566546002276 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 566546002277 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 566546002278 Fimbrial protein; Region: Fimbrial; pfam00419 566546002279 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 566546002280 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 566546002281 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 566546002282 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 566546002283 PapC N-terminal domain; Region: PapC_N; pfam13954 566546002284 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 566546002285 PapC C-terminal domain; Region: PapC_C; pfam13953 566546002286 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 566546002287 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 566546002288 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 566546002289 dimer interface [polypeptide binding]; other site 566546002290 active site 566546002291 citrylCoA binding site [chemical binding]; other site 566546002292 NADH binding [chemical binding]; other site 566546002293 cationic pore residues; other site 566546002294 oxalacetate/citrate binding site [chemical binding]; other site 566546002295 coenzyme A binding site [chemical binding]; other site 566546002296 catalytic triad [active] 566546002297 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 566546002298 Iron-sulfur protein interface; other site 566546002299 proximal quinone binding site [chemical binding]; other site 566546002300 SdhD (CybS) interface [polypeptide binding]; other site 566546002301 proximal heme binding site [chemical binding]; other site 566546002302 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 566546002303 SdhC subunit interface [polypeptide binding]; other site 566546002304 proximal heme binding site [chemical binding]; other site 566546002305 cardiolipin binding site; other site 566546002306 Iron-sulfur protein interface; other site 566546002307 proximal quinone binding site [chemical binding]; other site 566546002308 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 566546002309 L-aspartate oxidase; Provisional; Region: PRK06175 566546002310 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 566546002311 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 566546002312 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 566546002313 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 566546002314 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 566546002315 TPP-binding site [chemical binding]; other site 566546002316 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 566546002317 dimer interface [polypeptide binding]; other site 566546002318 PYR/PP interface [polypeptide binding]; other site 566546002319 TPP binding site [chemical binding]; other site 566546002320 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 566546002321 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 566546002322 E3 interaction surface; other site 566546002323 lipoyl attachment site [posttranslational modification]; other site 566546002324 e3 binding domain; Region: E3_binding; pfam02817 566546002325 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 566546002326 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 566546002327 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 566546002328 CoA-ligase; Region: Ligase_CoA; pfam00549 566546002329 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 566546002330 CoA binding domain; Region: CoA_binding; smart00881 566546002331 CoA-ligase; Region: Ligase_CoA; pfam00549 566546002332 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 566546002333 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 566546002334 DNA-binding site [nucleotide binding]; DNA binding site 566546002335 UTRA domain; Region: UTRA; pfam07702 566546002336 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 566546002337 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 566546002338 active site 566546002339 phosphorylation site [posttranslational modification] 566546002340 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 566546002341 active site 566546002342 P-loop; other site 566546002343 phosphorylation site [posttranslational modification] 566546002344 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 566546002345 alpha-mannosidase; Provisional; Region: PRK09819 566546002346 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 566546002347 active site 566546002348 metal binding site [ion binding]; metal-binding site 566546002349 catalytic site [active] 566546002350 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 566546002351 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 566546002352 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 566546002353 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 566546002354 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 566546002355 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 566546002356 hypothetical protein; Provisional; Region: PRK10588 566546002357 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 566546002358 active site 566546002359 colicin uptake protein TolQ; Provisional; Region: PRK10801 566546002360 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 566546002361 colicin uptake protein TolR; Provisional; Region: PRK11024 566546002362 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 566546002363 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 566546002364 TolA C-terminal; Region: TolA; pfam06519 566546002365 translocation protein TolB; Provisional; Region: tolB; PRK03629 566546002366 TolB amino-terminal domain; Region: TolB_N; pfam04052 566546002367 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 566546002368 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 566546002369 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 566546002370 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 566546002371 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 566546002372 ligand binding site [chemical binding]; other site 566546002373 tol-pal system protein YbgF; Provisional; Region: PRK10803 566546002374 Tetratricopeptide repeat; Region: TPR_6; pfam13174 566546002375 Tetratricopeptide repeat; Region: TPR_6; pfam13174 566546002376 quinolinate synthetase; Provisional; Region: PRK09375 566546002377 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 566546002378 zinc transporter ZitB; Provisional; Region: PRK03557 566546002379 YbgS-like protein; Region: YbgS; pfam13985 566546002380 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 566546002381 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 566546002382 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 566546002383 catalytic core [active] 566546002384 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 566546002385 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 566546002386 active site 566546002387 catalytic residues [active] 566546002388 galactokinase; Provisional; Region: PRK05101 566546002389 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 566546002390 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 566546002391 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 566546002392 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 566546002393 dimer interface [polypeptide binding]; other site 566546002394 active site 566546002395 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 566546002396 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 566546002397 NAD binding site [chemical binding]; other site 566546002398 homodimer interface [polypeptide binding]; other site 566546002399 active site 566546002400 substrate binding site [chemical binding]; other site 566546002401 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 566546002402 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 566546002403 Walker A/P-loop; other site 566546002404 ATP binding site [chemical binding]; other site 566546002405 Q-loop/lid; other site 566546002406 ABC transporter signature motif; other site 566546002407 Walker B; other site 566546002408 D-loop; other site 566546002409 H-loop/switch region; other site 566546002410 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 566546002411 Walker A/P-loop; other site 566546002412 ATP binding site [chemical binding]; other site 566546002413 Q-loop/lid; other site 566546002414 ABC transporter signature motif; other site 566546002415 Walker B; other site 566546002416 D-loop; other site 566546002417 H-loop/switch region; other site 566546002418 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 566546002419 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 566546002420 molybdenum-pterin binding domain; Region: Mop; TIGR00638 566546002421 TOBE domain; Region: TOBE; pfam03459 566546002422 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 566546002423 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 566546002424 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 566546002425 substrate binding pocket [chemical binding]; other site 566546002426 membrane-bound complex binding site; other site 566546002427 hinge residues; other site 566546002428 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 566546002429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546002430 putative PBP binding loops; other site 566546002431 ABC-ATPase subunit interface; other site 566546002432 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 566546002433 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 566546002434 Walker A/P-loop; other site 566546002435 ATP binding site [chemical binding]; other site 566546002436 Q-loop/lid; other site 566546002437 ABC transporter signature motif; other site 566546002438 Walker B; other site 566546002439 D-loop; other site 566546002440 H-loop/switch region; other site 566546002441 molybdenum-pterin binding domain; Region: Mop; TIGR00638 566546002442 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 566546002443 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 566546002444 motif II; other site 566546002445 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 566546002446 6-phosphogluconolactonase; Provisional; Region: PRK11028 566546002447 Transcriptional regulator [Transcription]; Region: LysR; COG0583 566546002448 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546002449 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 566546002450 putative dimerization interface [polypeptide binding]; other site 566546002451 PrpF protein; Region: PrpF; pfam04303 566546002452 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 566546002453 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 566546002454 transmembrane helices; other site 566546002455 putative hydratase; Provisional; Region: PRK11413 566546002456 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 566546002457 substrate binding site [chemical binding]; other site 566546002458 ligand binding site [chemical binding]; other site 566546002459 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 566546002460 substrate binding site [chemical binding]; other site 566546002461 acyl-CoA thioesterase; Provisional; Region: PRK10531 566546002462 putative pectinesterase; Region: PLN02432; cl01911 566546002463 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 566546002464 substrate binding site [chemical binding]; other site 566546002465 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 566546002466 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 566546002467 inhibitor-cofactor binding pocket; inhibition site 566546002468 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546002469 catalytic residue [active] 566546002470 biotin synthase; Provisional; Region: PRK15108 566546002471 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 566546002472 FeS/SAM binding site; other site 566546002473 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 566546002474 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 566546002475 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 566546002476 substrate-cofactor binding pocket; other site 566546002477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546002478 catalytic residue [active] 566546002479 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 566546002480 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546002481 S-adenosylmethionine binding site [chemical binding]; other site 566546002482 AAA domain; Region: AAA_26; pfam13500 566546002483 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 566546002484 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 566546002485 ADP binding site [chemical binding]; other site 566546002486 excinuclease ABC subunit B; Provisional; Region: PRK05298 566546002487 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 566546002488 ATP binding site [chemical binding]; other site 566546002489 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 566546002490 nucleotide binding region [chemical binding]; other site 566546002491 ATP-binding site [chemical binding]; other site 566546002492 Ultra-violet resistance protein B; Region: UvrB; pfam12344 566546002493 UvrB/uvrC motif; Region: UVR; pfam02151 566546002494 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 566546002495 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 566546002496 putative substrate binding pocket [chemical binding]; other site 566546002497 dimer interface [polypeptide binding]; other site 566546002498 phosphate binding site [ion binding]; other site 566546002499 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 566546002500 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 566546002501 FeS/SAM binding site; other site 566546002502 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 566546002503 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 566546002504 MPT binding site; other site 566546002505 trimer interface [polypeptide binding]; other site 566546002506 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 566546002507 trimer interface [polypeptide binding]; other site 566546002508 dimer interface [polypeptide binding]; other site 566546002509 putative active site [active] 566546002510 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 566546002511 MoaE interaction surface [polypeptide binding]; other site 566546002512 MoeB interaction surface [polypeptide binding]; other site 566546002513 thiocarboxylated glycine; other site 566546002514 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 566546002515 MoaE homodimer interface [polypeptide binding]; other site 566546002516 MoaD interaction [polypeptide binding]; other site 566546002517 active site residues [active] 566546002518 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 566546002519 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 566546002520 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 566546002521 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 566546002522 Predicted integral membrane protein [Function unknown]; Region: COG0392 566546002523 cardiolipin synthase 2; Provisional; Region: PRK11263 566546002524 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 566546002525 putative active site [active] 566546002526 catalytic site [active] 566546002527 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 566546002528 putative active site [active] 566546002529 catalytic site [active] 566546002530 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 566546002531 putative catalytic site [active] 566546002532 putative metal binding site [ion binding]; other site 566546002533 putative phosphate binding site [ion binding]; other site 566546002534 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 566546002535 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 566546002536 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 566546002537 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 566546002538 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 566546002539 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 566546002540 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 566546002541 Walker A/P-loop; other site 566546002542 ATP binding site [chemical binding]; other site 566546002543 Q-loop/lid; other site 566546002544 ABC transporter signature motif; other site 566546002545 Walker B; other site 566546002546 D-loop; other site 566546002547 H-loop/switch region; other site 566546002548 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 566546002549 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 566546002550 Walker A/P-loop; other site 566546002551 ATP binding site [chemical binding]; other site 566546002552 Q-loop/lid; other site 566546002553 ABC transporter signature motif; other site 566546002554 Walker B; other site 566546002555 D-loop; other site 566546002556 H-loop/switch region; other site 566546002557 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 566546002558 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 566546002559 HlyD family secretion protein; Region: HlyD_3; pfam13437 566546002560 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 566546002561 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 566546002562 helicase 45; Provisional; Region: PTZ00424 566546002563 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 566546002564 ATP binding site [chemical binding]; other site 566546002565 Mg++ binding site [ion binding]; other site 566546002566 motif III; other site 566546002567 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 566546002568 nucleotide binding region [chemical binding]; other site 566546002569 ATP-binding site [chemical binding]; other site 566546002570 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236 566546002571 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 566546002572 DEAD_2; Region: DEAD_2; pfam06733 566546002573 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 566546002574 glycosyl transferase family protein; Provisional; Region: PRK08136 566546002575 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 566546002576 putative dehydrogenase; Provisional; Region: PRK10098 566546002577 hypothetical protein; Provisional; Region: PRK10259 566546002578 hypothetical protein; Provisional; Region: PRK11019 566546002579 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 566546002580 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 566546002581 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 566546002582 N-terminal plug; other site 566546002583 ligand-binding site [chemical binding]; other site 566546002584 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 566546002585 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 566546002586 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 566546002587 putative mechanosensitive channel protein; Provisional; Region: PRK11465 566546002588 Mechanosensitive ion channel; Region: MS_channel; pfam00924 566546002589 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 566546002590 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 566546002591 Walker A/P-loop; other site 566546002592 ATP binding site [chemical binding]; other site 566546002593 Q-loop/lid; other site 566546002594 ABC transporter signature motif; other site 566546002595 Walker B; other site 566546002596 D-loop; other site 566546002597 H-loop/switch region; other site 566546002598 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 566546002599 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546002600 dimer interface [polypeptide binding]; other site 566546002601 conserved gate region; other site 566546002602 putative PBP binding loops; other site 566546002603 ABC-ATPase subunit interface; other site 566546002604 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 566546002605 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 566546002606 substrate binding pocket [chemical binding]; other site 566546002607 membrane-bound complex binding site; other site 566546002608 hinge residues; other site 566546002609 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 566546002610 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 566546002611 dimerization interface [polypeptide binding]; other site 566546002612 DPS ferroxidase diiron center [ion binding]; other site 566546002613 ion pore; other site 566546002614 threonine and homoserine efflux system; Provisional; Region: PRK10532 566546002615 EamA-like transporter family; Region: EamA; pfam00892 566546002616 outer membrane protein X; Provisional; Region: ompX; PRK09408 566546002617 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 566546002618 Sulfatase; Region: Sulfatase; pfam00884 566546002619 manganese transport regulator MntR; Provisional; Region: PRK11050 566546002620 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 566546002621 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 566546002622 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 566546002623 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 566546002624 transmembrane helices; other site 566546002625 L,D-transpeptidase; Provisional; Region: PRK10260 566546002626 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 566546002627 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 566546002628 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 566546002629 Walker A/P-loop; other site 566546002630 ATP binding site [chemical binding]; other site 566546002631 Q-loop/lid; other site 566546002632 ABC transporter signature motif; other site 566546002633 Walker B; other site 566546002634 D-loop; other site 566546002635 H-loop/switch region; other site 566546002636 ABC transporter; Region: ABC_tran_2; pfam12848 566546002637 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 566546002638 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 566546002639 Transposase; Region: DEDD_Tnp_IS110; pfam01548 566546002640 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 566546002641 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 566546002642 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 566546002643 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 566546002644 active site 566546002645 motif I; other site 566546002646 motif II; other site 566546002647 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 566546002648 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 566546002649 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 566546002650 dimer interface [polypeptide binding]; other site 566546002651 active site 566546002652 glycine loop; other site 566546002653 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 566546002654 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 566546002655 active site 566546002656 intersubunit interactions; other site 566546002657 catalytic residue [active] 566546002658 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 566546002659 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 566546002660 ATP binding site [chemical binding]; other site 566546002661 substrate interface [chemical binding]; other site 566546002662 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 566546002663 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 566546002664 dimer interface [polypeptide binding]; other site 566546002665 putative functional site; other site 566546002666 putative MPT binding site; other site 566546002667 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 566546002668 catalytic nucleophile [active] 566546002669 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 566546002670 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 566546002671 Walker A/P-loop; other site 566546002672 ATP binding site [chemical binding]; other site 566546002673 Q-loop/lid; other site 566546002674 ABC transporter signature motif; other site 566546002675 Walker B; other site 566546002676 D-loop; other site 566546002677 H-loop/switch region; other site 566546002678 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 566546002679 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 566546002680 Walker A/P-loop; other site 566546002681 ATP binding site [chemical binding]; other site 566546002682 Q-loop/lid; other site 566546002683 ABC transporter signature motif; other site 566546002684 Walker B; other site 566546002685 D-loop; other site 566546002686 H-loop/switch region; other site 566546002687 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 566546002688 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 566546002689 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 566546002690 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 566546002691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546002692 dimer interface [polypeptide binding]; other site 566546002693 conserved gate region; other site 566546002694 putative PBP binding loops; other site 566546002695 ABC-ATPase subunit interface; other site 566546002696 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 566546002697 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 566546002698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546002699 dimer interface [polypeptide binding]; other site 566546002700 conserved gate region; other site 566546002701 putative PBP binding loops; other site 566546002702 ABC-ATPase subunit interface; other site 566546002703 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 566546002704 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 566546002705 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 566546002706 metal binding site [ion binding]; metal-binding site 566546002707 active site 566546002708 I-site; other site 566546002709 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 566546002710 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 566546002711 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 566546002712 FeS/SAM binding site; other site 566546002713 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 566546002714 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 566546002715 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 566546002716 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 566546002717 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 566546002718 putative C-terminal domain interface [polypeptide binding]; other site 566546002719 putative GSH binding site (G-site) [chemical binding]; other site 566546002720 putative dimer interface [polypeptide binding]; other site 566546002721 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 566546002722 N-terminal domain interface [polypeptide binding]; other site 566546002723 dimer interface [polypeptide binding]; other site 566546002724 substrate binding pocket (H-site) [chemical binding]; other site 566546002725 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 566546002726 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 566546002727 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 566546002728 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 566546002729 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 566546002730 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 566546002731 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 566546002732 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 566546002733 active site 566546002734 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 566546002735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546002736 putative substrate translocation pore; other site 566546002737 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 566546002738 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 566546002739 active site 566546002740 motif I; other site 566546002741 motif II; other site 566546002742 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 566546002743 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 566546002744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546002745 putative substrate translocation pore; other site 566546002746 Major Facilitator Superfamily; Region: MFS_1; pfam07690 566546002747 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 566546002748 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 566546002749 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 566546002750 integrase; Provisional; Region: int; PHA02601 566546002751 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 566546002752 active site 566546002753 DNA binding site [nucleotide binding] 566546002754 Int/Topo IB signature motif; other site 566546002755 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 566546002756 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 566546002757 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 566546002758 Helix-turn-helix domain; Region: HTH_17; cl17695 566546002759 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 566546002760 Protein of unknown function (DUF2724); Region: DUF2724; pfam10893 566546002761 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 566546002762 DksA-like zinc finger domain containing protein; Region: PHA00080 566546002763 DNA adenine methylase (dam); Region: dam; TIGR00571 566546002764 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 566546002765 DinI-like family; Region: DinI; pfam06183 566546002766 Protein of unknown function DUF262; Region: DUF262; pfam03235 566546002767 Uncharacterized conserved protein [Function unknown]; Region: COG1479 566546002768 portal vertex protein; Provisional; Region: Q; PHA02536 566546002769 Phage portal protein; Region: Phage_portal; pfam04860 566546002770 terminase ATPase subunit; Provisional; Region: P; PHA02535 566546002771 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 566546002772 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 566546002773 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929 566546002774 capsid protein; Provisional; Region: N; PHA02538 566546002775 terminase endonuclease subunit; Provisional; Region: M; PHA02537 566546002776 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 566546002777 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 566546002778 P2-like prophage tail protein X [General function prediction only]; Region: COG5004 566546002779 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 566546002780 catalytic residues [active] 566546002781 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 566546002782 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 566546002783 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 566546002784 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 566546002785 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 566546002786 baseplate wedge subunit; Provisional; Region: W; PHA02516 566546002787 baseplate assembly protein; Provisional; Region: J; PHA02568 566546002788 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 566546002789 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 566546002790 Integrase core domain; Region: rve; pfam00665 566546002791 DDE domain; Region: DDE_Tnp_IS240; pfam13610 566546002792 Integrase core domain; Region: rve_3; pfam13683 566546002793 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 566546002794 Transposase; Region: HTH_Tnp_1; cl17663 566546002795 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 566546002796 pseudogene, conserved hypothetical protein 566546002797 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 566546002798 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 566546002799 catalytic residues [active] 566546002800 catalytic nucleophile [active] 566546002801 Presynaptic Site I dimer interface [polypeptide binding]; other site 566546002802 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 566546002803 Synaptic Flat tetramer interface [polypeptide binding]; other site 566546002804 Synaptic Site I dimer interface [polypeptide binding]; other site 566546002805 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 566546002806 DNA-binding interface [nucleotide binding]; DNA binding site 566546002807 major tail sheath protein; Provisional; Region: FI; PHA02560 566546002808 major tail tube protein; Provisional; Region: FII; PHA02600 566546002809 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 566546002810 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 566546002811 Phage protein U [General function prediction only]; Region: COG3499 566546002812 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 566546002813 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 566546002814 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 566546002815 putative transporter; Provisional; Region: PRK04972 566546002816 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 566546002817 TrkA-C domain; Region: TrkA_C; pfam02080 566546002818 TrkA-C domain; Region: TrkA_C; pfam02080 566546002819 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 566546002820 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 566546002821 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 566546002822 GSH binding site [chemical binding]; other site 566546002823 catalytic residues [active] 566546002824 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 566546002825 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 566546002826 dimer interface [polypeptide binding]; other site 566546002827 FMN binding site [chemical binding]; other site 566546002828 NADPH bind site [chemical binding]; other site 566546002829 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 566546002830 RimK-like ATP-grasp domain; Region: RimK; pfam08443 566546002831 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 566546002832 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 566546002833 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 566546002834 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 566546002835 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 566546002836 Walker A/P-loop; other site 566546002837 ATP binding site [chemical binding]; other site 566546002838 Q-loop/lid; other site 566546002839 ABC transporter signature motif; other site 566546002840 Walker B; other site 566546002841 D-loop; other site 566546002842 H-loop/switch region; other site 566546002843 TOBE domain; Region: TOBE_2; pfam08402 566546002844 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 566546002845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546002846 dimer interface [polypeptide binding]; other site 566546002847 conserved gate region; other site 566546002848 putative PBP binding loops; other site 566546002849 ABC-ATPase subunit interface; other site 566546002850 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 566546002851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546002852 dimer interface [polypeptide binding]; other site 566546002853 conserved gate region; other site 566546002854 putative PBP binding loops; other site 566546002855 ABC-ATPase subunit interface; other site 566546002856 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 566546002857 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 566546002858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546002859 S-adenosylmethionine binding site [chemical binding]; other site 566546002860 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 566546002861 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 566546002862 substrate binding pocket [chemical binding]; other site 566546002863 membrane-bound complex binding site; other site 566546002864 hinge residues; other site 566546002865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546002866 dimer interface [polypeptide binding]; other site 566546002867 conserved gate region; other site 566546002868 putative PBP binding loops; other site 566546002869 ABC-ATPase subunit interface; other site 566546002870 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 566546002871 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546002872 dimer interface [polypeptide binding]; other site 566546002873 conserved gate region; other site 566546002874 putative PBP binding loops; other site 566546002875 ABC-ATPase subunit interface; other site 566546002876 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 566546002877 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 566546002878 substrate binding pocket [chemical binding]; other site 566546002879 membrane-bound complex binding site; other site 566546002880 hinge residues; other site 566546002881 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 566546002882 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 566546002883 Walker A/P-loop; other site 566546002884 ATP binding site [chemical binding]; other site 566546002885 Q-loop/lid; other site 566546002886 ABC transporter signature motif; other site 566546002887 Walker B; other site 566546002888 D-loop; other site 566546002889 H-loop/switch region; other site 566546002890 putative lipoprotein; Provisional; Region: PRK10533 566546002891 hypothetical protein; Provisional; Region: PRK02877 566546002892 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 566546002893 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 566546002894 amidase catalytic site [active] 566546002895 Zn binding residues [ion binding]; other site 566546002896 substrate binding site [chemical binding]; other site 566546002897 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 566546002898 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 566546002899 NAD(P) binding site [chemical binding]; other site 566546002900 active site 566546002901 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 566546002902 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 566546002903 putative NAD(P) binding site [chemical binding]; other site 566546002904 putative active site [active] 566546002905 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 566546002906 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 566546002907 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 566546002908 tetramer interface [polypeptide binding]; other site 566546002909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546002910 catalytic residue [active] 566546002911 pyruvate dehydrogenase; Provisional; Region: PRK09124 566546002912 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 566546002913 PYR/PP interface [polypeptide binding]; other site 566546002914 dimer interface [polypeptide binding]; other site 566546002915 tetramer interface [polypeptide binding]; other site 566546002916 TPP binding site [chemical binding]; other site 566546002917 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 566546002918 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 566546002919 TPP-binding site [chemical binding]; other site 566546002920 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 566546002921 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 566546002922 FAD binding pocket [chemical binding]; other site 566546002923 FAD binding motif [chemical binding]; other site 566546002924 phosphate binding motif [ion binding]; other site 566546002925 beta-alpha-beta structure motif; other site 566546002926 NAD binding pocket [chemical binding]; other site 566546002927 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 566546002928 catalytic loop [active] 566546002929 iron binding site [ion binding]; other site 566546002930 hybrid cluster protein; Provisional; Region: PRK05290 566546002931 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 566546002932 ACS interaction site; other site 566546002933 CODH interaction site; other site 566546002934 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 566546002935 hybrid metal cluster; other site 566546002936 Predicted membrane protein [Function unknown]; Region: COG2431 566546002937 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 566546002938 amphipathic channel; other site 566546002939 Asn-Pro-Ala signature motifs; other site 566546002940 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 566546002941 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 566546002942 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 566546002943 putative active site [active] 566546002944 putative metal-binding site [ion binding]; other site 566546002945 Protein of unknown function (DUF535); Region: DUF535; pfam04393 566546002946 macrolide transporter subunit MacA; Provisional; Region: PRK11578 566546002947 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 566546002948 HlyD family secretion protein; Region: HlyD_3; pfam13437 566546002949 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 566546002950 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 566546002951 Walker A/P-loop; other site 566546002952 ATP binding site [chemical binding]; other site 566546002953 Q-loop/lid; other site 566546002954 ABC transporter signature motif; other site 566546002955 Walker B; other site 566546002956 D-loop; other site 566546002957 H-loop/switch region; other site 566546002958 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 566546002959 FtsX-like permease family; Region: FtsX; pfam02687 566546002960 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 566546002961 DNA-binding site [nucleotide binding]; DNA binding site 566546002962 RNA-binding motif; other site 566546002963 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 566546002964 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 566546002965 Clp amino terminal domain; Region: Clp_N; pfam02861 566546002966 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546002967 Walker A motif; other site 566546002968 ATP binding site [chemical binding]; other site 566546002969 Walker B motif; other site 566546002970 arginine finger; other site 566546002971 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546002972 Walker A motif; other site 566546002973 ATP binding site [chemical binding]; other site 566546002974 Walker B motif; other site 566546002975 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 566546002976 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 566546002977 rRNA binding site [nucleotide binding]; other site 566546002978 predicted 30S ribosome binding site; other site 566546002979 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 566546002980 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 566546002981 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 566546002982 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 566546002983 Walker A/P-loop; other site 566546002984 ATP binding site [chemical binding]; other site 566546002985 Q-loop/lid; other site 566546002986 ABC transporter signature motif; other site 566546002987 Walker B; other site 566546002988 D-loop; other site 566546002989 H-loop/switch region; other site 566546002990 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 566546002991 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 566546002992 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 566546002993 Walker A/P-loop; other site 566546002994 ATP binding site [chemical binding]; other site 566546002995 Q-loop/lid; other site 566546002996 ABC transporter signature motif; other site 566546002997 Walker B; other site 566546002998 D-loop; other site 566546002999 H-loop/switch region; other site 566546003000 thioredoxin reductase; Provisional; Region: PRK10262 566546003001 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 566546003002 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 566546003003 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 566546003004 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 566546003005 putative DNA binding site [nucleotide binding]; other site 566546003006 putative Zn2+ binding site [ion binding]; other site 566546003007 AsnC family; Region: AsnC_trans_reg; pfam01037 566546003008 DNA translocase FtsK; Provisional; Region: PRK10263 566546003009 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 566546003010 DNA translocase FtsK; Provisional; Region: PRK10263 566546003011 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 566546003012 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 566546003013 periplasmic chaperone LolA; Region: lolA; TIGR00547 566546003014 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 566546003015 recombination factor protein RarA; Reviewed; Region: PRK13342 566546003016 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546003017 Walker A motif; other site 566546003018 ATP binding site [chemical binding]; other site 566546003019 Walker B motif; other site 566546003020 arginine finger; other site 566546003021 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 566546003022 seryl-tRNA synthetase; Provisional; Region: PRK05431 566546003023 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 566546003024 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 566546003025 dimer interface [polypeptide binding]; other site 566546003026 active site 566546003027 motif 1; other site 566546003028 motif 2; other site 566546003029 motif 3; other site 566546003030 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 566546003031 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 566546003032 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 566546003033 putative [Fe4-S4] binding site [ion binding]; other site 566546003034 putative molybdopterin cofactor binding site [chemical binding]; other site 566546003035 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 566546003036 putative molybdopterin cofactor binding site; other site 566546003037 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 566546003038 4Fe-4S binding domain; Region: Fer4; pfam00037 566546003039 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 566546003040 Isochorismatase family; Region: Isochorismatase; pfam00857 566546003041 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 566546003042 catalytic triad [active] 566546003043 dimer interface [polypeptide binding]; other site 566546003044 conserved cis-peptide bond; other site 566546003045 putative MFS family transporter protein; Provisional; Region: PRK03633 566546003046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546003047 putative substrate translocation pore; other site 566546003048 Amino acid permease; Region: AA_permease_2; pfam13520 566546003049 Transcriptional regulator [Transcription]; Region: LysR; COG0583 566546003050 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546003051 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 566546003052 putative effector binding pocket; other site 566546003053 putative dimerization interface [polypeptide binding]; other site 566546003054 hypothetical protein; Provisional; Region: PRK09739 566546003055 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 566546003056 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 566546003057 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 566546003058 FeS/SAM binding site; other site 566546003059 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 566546003060 Pyruvate formate lyase 1; Region: PFL1; cd01678 566546003061 coenzyme A binding site [chemical binding]; other site 566546003062 active site 566546003063 catalytic residues [active] 566546003064 glycine loop; other site 566546003065 formate transporter; Provisional; Region: PRK10805 566546003066 uncharacterized domain; Region: TIGR00702 566546003067 YcaO-like family; Region: YcaO; pfam02624 566546003068 Predicted membrane protein [Function unknown]; Region: COG2323 566546003069 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 566546003070 homodimer interface [polypeptide binding]; other site 566546003071 substrate-cofactor binding pocket; other site 566546003072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546003073 catalytic residue [active] 566546003074 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 566546003075 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 566546003076 hinge; other site 566546003077 active site 566546003078 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 566546003079 cytidylate kinase; Provisional; Region: cmk; PRK00023 566546003080 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 566546003081 CMP-binding site; other site 566546003082 The sites determining sugar specificity; other site 566546003083 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 566546003084 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 566546003085 RNA binding site [nucleotide binding]; other site 566546003086 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 566546003087 RNA binding site [nucleotide binding]; other site 566546003088 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 566546003089 RNA binding site [nucleotide binding]; other site 566546003090 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 566546003091 RNA binding site [nucleotide binding]; other site 566546003092 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 566546003093 RNA binding site [nucleotide binding]; other site 566546003094 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 566546003095 IHF dimer interface [polypeptide binding]; other site 566546003096 IHF - DNA interface [nucleotide binding]; other site 566546003097 ComEC family competence protein; Provisional; Region: PRK11539 566546003098 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 566546003099 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 566546003100 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 566546003101 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 566546003102 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 566546003103 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 566546003104 Walker A/P-loop; other site 566546003105 ATP binding site [chemical binding]; other site 566546003106 Q-loop/lid; other site 566546003107 ABC transporter signature motif; other site 566546003108 Walker B; other site 566546003109 D-loop; other site 566546003110 H-loop/switch region; other site 566546003111 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 566546003112 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 566546003113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 566546003114 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 566546003115 hypothetical protein; Provisional; Region: PRK11827 566546003116 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 566546003117 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 566546003118 Ligand binding site; other site 566546003119 oligomer interface; other site 566546003120 hypothetical protein; Provisional; Region: PRK10593 566546003121 Uncharacterized conserved protein [Function unknown]; Region: COG1434 566546003122 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 566546003123 putative active site [active] 566546003124 Methyltransferase domain; Region: Methyltransf_31; pfam13847 566546003125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546003126 S-adenosylmethionine binding site [chemical binding]; other site 566546003127 condesin subunit F; Provisional; Region: PRK05260 566546003128 condesin subunit E; Provisional; Region: PRK05256 566546003129 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 566546003130 MukB N-terminal; Region: MukB; pfam04310 566546003131 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 566546003132 murein L,D-transpeptidase; Provisional; Region: PRK10594 566546003133 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 566546003134 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 566546003135 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 566546003136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 566546003137 Peptidase M15; Region: Peptidase_M15_3; cl01194 566546003138 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 566546003139 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 566546003140 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 566546003141 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546003142 homodimer interface [polypeptide binding]; other site 566546003143 catalytic residue [active] 566546003144 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 566546003145 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 566546003146 trimer interface [polypeptide binding]; other site 566546003147 eyelet of channel; other site 566546003148 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 566546003149 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 566546003150 putative dimer interface [polypeptide binding]; other site 566546003151 putative anticodon binding site; other site 566546003152 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 566546003153 homodimer interface [polypeptide binding]; other site 566546003154 motif 1; other site 566546003155 motif 2; other site 566546003156 active site 566546003157 motif 3; other site 566546003158 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 566546003159 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 566546003160 active site 566546003161 aminopeptidase N; Provisional; Region: pepN; PRK14015 566546003162 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 566546003163 active site 566546003164 Zn binding site [ion binding]; other site 566546003165 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 566546003166 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 566546003167 Walker A/P-loop; other site 566546003168 ATP binding site [chemical binding]; other site 566546003169 Q-loop/lid; other site 566546003170 ABC transporter signature motif; other site 566546003171 Walker B; other site 566546003172 D-loop; other site 566546003173 H-loop/switch region; other site 566546003174 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 566546003175 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546003176 dimer interface [polypeptide binding]; other site 566546003177 conserved gate region; other site 566546003178 putative PBP binding loops; other site 566546003179 ABC-ATPase subunit interface; other site 566546003180 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 566546003181 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 566546003182 active site 566546003183 dimer interface [polypeptide binding]; other site 566546003184 non-prolyl cis peptide bond; other site 566546003185 insertion regions; other site 566546003186 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 566546003187 substrate binding pocket [chemical binding]; other site 566546003188 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 566546003189 membrane-bound complex binding site; other site 566546003190 hinge residues; other site 566546003191 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 566546003192 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 566546003193 Fimbrial protein; Region: Fimbrial; cl01416 566546003194 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 566546003195 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 566546003196 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 566546003197 outer membrane usher protein; Provisional; Region: PRK15193 566546003198 PapC N-terminal domain; Region: PapC_N; pfam13954 566546003199 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 566546003200 PapC C-terminal domain; Region: PapC_C; pfam13953 566546003201 Fimbrial protein; Region: Fimbrial; cl01416 566546003202 Fimbrial protein; Region: Fimbrial; cl01416 566546003203 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 566546003204 putativi pili assembly chaperone; Provisional; Region: PRK11385 566546003205 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 566546003206 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 566546003207 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 566546003208 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 566546003209 quinone interaction residues [chemical binding]; other site 566546003210 active site 566546003211 catalytic residues [active] 566546003212 FMN binding site [chemical binding]; other site 566546003213 substrate binding site [chemical binding]; other site 566546003214 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 566546003215 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 566546003216 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 566546003217 MOSC domain; Region: MOSC; pfam03473 566546003218 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 566546003219 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 566546003220 catalytic loop [active] 566546003221 iron binding site [ion binding]; other site 566546003222 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 566546003223 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 566546003224 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 566546003225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546003226 S-adenosylmethionine binding site [chemical binding]; other site 566546003227 ABC transporter ATPase component; Reviewed; Region: PRK11147 566546003228 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 566546003229 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 566546003230 Walker A/P-loop; other site 566546003231 Walker A/P-loop; other site 566546003232 ATP binding site [chemical binding]; other site 566546003233 ATP binding site [chemical binding]; other site 566546003234 Q-loop/lid; other site 566546003235 Q-loop/lid; other site 566546003236 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 566546003237 ABC transporter signature motif; other site 566546003238 Walker B; other site 566546003239 D-loop; other site 566546003240 ABC transporter; Region: ABC_tran_2; pfam12848 566546003241 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 566546003242 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 566546003243 Paraquat-inducible protein A; Region: PqiA; pfam04403 566546003244 Paraquat-inducible protein A; Region: PqiA; pfam04403 566546003245 paraquat-inducible protein B; Provisional; Region: PRK10807 566546003246 mce related protein; Region: MCE; pfam02470 566546003247 mce related protein; Region: MCE; pfam02470 566546003248 mce related protein; Region: MCE; pfam02470 566546003249 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 566546003250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 566546003251 Protein of unknown function (DUF330); Region: DUF330; pfam03886 566546003252 ribosome modulation factor; Provisional; Region: PRK14563 566546003253 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 566546003254 active site 1 [active] 566546003255 dimer interface [polypeptide binding]; other site 566546003256 active site 2 [active] 566546003257 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 566546003258 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 566546003259 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 566546003260 outer membrane protein A; Reviewed; Region: PRK10808 566546003261 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 566546003262 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 566546003263 ligand binding site [chemical binding]; other site 566546003264 cell division inhibitor SulA; Region: sula; TIGR00623 566546003265 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 566546003266 TfoX C-terminal domain; Region: TfoX_C; pfam04994 566546003267 TIGR01666 family membrane protein; Region: YCCS 566546003268 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 566546003269 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 566546003270 Predicted membrane protein [Function unknown]; Region: COG3304 566546003271 Domain of unknown function (DUF307); Region: DUF307; pfam03733 566546003272 Domain of unknown function (DUF307); Region: DUF307; pfam03733 566546003273 DNA helicase IV; Provisional; Region: helD; PRK11054 566546003274 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 566546003275 Part of AAA domain; Region: AAA_19; pfam13245 566546003276 Family description; Region: UvrD_C_2; pfam13538 566546003277 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 566546003278 active site 566546003279 dimer interfaces [polypeptide binding]; other site 566546003280 catalytic residues [active] 566546003281 hypothetical protein; Provisional; Region: PRK03641 566546003282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 566546003283 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 566546003284 heat shock protein HspQ; Provisional; Region: PRK14129 566546003285 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 566546003286 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 566546003287 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 566546003288 putative RNA binding site [nucleotide binding]; other site 566546003289 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546003290 S-adenosylmethionine binding site [chemical binding]; other site 566546003291 Acylphosphatase; Region: Acylphosphatase; cl00551 566546003292 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 566546003293 sulfur transfer protein TusE; Provisional; Region: PRK11508 566546003294 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 566546003295 YccA-like proteins; Region: YccA_like; cd10433 566546003296 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 566546003297 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 566546003298 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 566546003299 hydrogenase 1 large subunit; Provisional; Region: PRK10170 566546003300 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 566546003301 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 566546003302 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 566546003303 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 566546003304 putative substrate-binding site; other site 566546003305 nickel binding site [ion binding]; other site 566546003306 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 566546003307 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 566546003308 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 566546003309 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 566546003310 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 566546003311 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 566546003312 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 566546003313 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 566546003314 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 566546003315 catalytic core [active] 566546003316 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 566546003317 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 566546003318 Chain length determinant protein; Region: Wzz; pfam02706 566546003319 Chain length determinant protein; Region: Wzz; cl15801 566546003320 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 566546003321 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 566546003322 Nucleotide binding site [chemical binding]; other site 566546003323 Low molecular weight phosphatase family; Region: LMWPc; cd00115 566546003324 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 566546003325 active site 566546003326 polysaccharide export protein Wza; Provisional; Region: PRK15078 566546003327 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 566546003328 SLBB domain; Region: SLBB; pfam10531 566546003329 SLBB domain; Region: SLBB; pfam10531 566546003330 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 566546003331 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 566546003332 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 566546003333 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 566546003334 DNA-binding site [nucleotide binding]; DNA binding site 566546003335 RNA-binding motif; other site 566546003336 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 566546003337 DNA-binding site [nucleotide binding]; DNA binding site 566546003338 RNA-binding motif; other site 566546003339 GnsA/GnsB family; Region: GnsAB; pfam08178 566546003340 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 566546003341 4Fe-4S binding domain; Region: Fer4_5; pfam12801 566546003342 4Fe-4S binding domain; Region: Fer4_5; pfam12801 566546003343 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 566546003344 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 566546003345 HAMP domain; Region: HAMP; pfam00672 566546003346 dimerization interface [polypeptide binding]; other site 566546003347 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 566546003348 dimer interface [polypeptide binding]; other site 566546003349 phosphorylation site [posttranslational modification] 566546003350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546003351 ATP binding site [chemical binding]; other site 566546003352 Mg2+ binding site [ion binding]; other site 566546003353 G-X-G motif; other site 566546003354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546003355 active site 566546003356 phosphorylation site [posttranslational modification] 566546003357 intermolecular recognition site; other site 566546003358 dimerization interface [polypeptide binding]; other site 566546003359 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 566546003360 putative binding surface; other site 566546003361 active site 566546003362 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 566546003363 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 566546003364 putative ligand binding site [chemical binding]; other site 566546003365 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 566546003366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546003367 active site 566546003368 phosphorylation site [posttranslational modification] 566546003369 intermolecular recognition site; other site 566546003370 dimerization interface [polypeptide binding]; other site 566546003371 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 566546003372 DNA binding site [nucleotide binding] 566546003373 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 566546003374 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 566546003375 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 566546003376 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 566546003377 molybdopterin cofactor binding site [chemical binding]; other site 566546003378 substrate binding site [chemical binding]; other site 566546003379 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 566546003380 molybdopterin cofactor binding site; other site 566546003381 chaperone protein TorD; Validated; Region: torD; PRK04976 566546003382 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 566546003383 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 566546003384 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 566546003385 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 566546003386 HSP70 interaction site [polypeptide binding]; other site 566546003387 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 566546003388 substrate binding site [polypeptide binding]; other site 566546003389 dimer interface [polypeptide binding]; other site 566546003390 pseudogene, conserved hypothetical protein 566546003391 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 566546003392 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 566546003393 catalytic core [active] 566546003394 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 566546003395 hypothetical protein; Provisional; Region: PRK10174 566546003396 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 566546003397 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 566546003398 General stress protein [General function prediction only]; Region: GsiB; COG3729 566546003399 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 566546003400 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 566546003401 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 566546003402 putative FMN binding site [chemical binding]; other site 566546003403 pyrimidine utilization protein D; Region: RutD; TIGR03611 566546003404 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 566546003405 homotrimer interaction site [polypeptide binding]; other site 566546003406 putative active site [active] 566546003407 Isochorismatase family; Region: Isochorismatase; pfam00857 566546003408 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 566546003409 catalytic triad [active] 566546003410 conserved cis-peptide bond; other site 566546003411 pyrimidine utilization protein A; Region: RutA; TIGR03612 566546003412 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 566546003413 active site 566546003414 dimer interface [polypeptide binding]; other site 566546003415 non-prolyl cis peptide bond; other site 566546003416 insertion regions; other site 566546003417 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 566546003418 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 566546003419 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 566546003420 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 566546003421 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 566546003422 Predicted transcriptional regulator [Transcription]; Region: COG3905 566546003423 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 566546003424 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 566546003425 Glutamate binding site [chemical binding]; other site 566546003426 NAD binding site [chemical binding]; other site 566546003427 catalytic residues [active] 566546003428 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 566546003429 Na binding site [ion binding]; other site 566546003430 pseudogene, ferrous iron permease 566546003431 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 566546003432 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 566546003433 Imelysin; Region: Peptidase_M75; pfam09375 566546003434 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 566546003435 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 566546003436 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 566546003437 hypothetical protein; Provisional; Region: PRK10536 566546003438 putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585 566546003439 N-glycosyltransferase; Provisional; Region: PRK11204 566546003440 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 566546003441 DXD motif; other site 566546003442 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 566546003443 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 566546003444 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 566546003445 putative active site [active] 566546003446 putative metal binding site [ion binding]; other site 566546003447 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 566546003448 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 566546003449 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 566546003450 metal binding site [ion binding]; metal-binding site 566546003451 active site 566546003452 I-site; other site 566546003453 putative transposase OrfB; Reviewed; Region: PHA02517 566546003454 HTH-like domain; Region: HTH_21; pfam13276 566546003455 Integrase core domain; Region: rve; pfam00665 566546003456 Integrase core domain; Region: rve_2; pfam13333 566546003457 Transposase; Region: HTH_Tnp_1; cl17663 566546003458 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 566546003459 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 566546003460 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 566546003461 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 566546003462 putative ligand binding site [chemical binding]; other site 566546003463 NAD binding site [chemical binding]; other site 566546003464 dimerization interface [polypeptide binding]; other site 566546003465 catalytic site [active] 566546003466 putative hydrolase; Validated; Region: PRK09248 566546003467 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 566546003468 active site 566546003469 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 566546003470 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 566546003471 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 566546003472 curli assembly protein CsgF; Provisional; Region: PRK10050 566546003473 curli assembly protein CsgE; Provisional; Region: PRK10386 566546003474 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 566546003475 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 566546003476 DNA binding residues [nucleotide binding] 566546003477 dimerization interface [polypeptide binding]; other site 566546003478 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 566546003479 Curlin associated repeat; Region: Curlin_rpt; pfam07012 566546003480 Curlin associated repeat; Region: Curlin_rpt; pfam07012 566546003481 major curlin subunit; Provisional; Region: csgA; PRK10051 566546003482 Curlin associated repeat; Region: Curlin_rpt; pfam07012 566546003483 Curlin associated repeat; Region: Curlin_rpt; pfam07012 566546003484 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 566546003485 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 566546003486 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 566546003487 putative ADP-ribose binding site [chemical binding]; other site 566546003488 putative active site [active] 566546003489 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 566546003490 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 566546003491 putative active site [active] 566546003492 catalytic site [active] 566546003493 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 566546003494 putative active site [active] 566546003495 catalytic site [active] 566546003496 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 566546003497 Acyltransferase family; Region: Acyl_transf_3; pfam01757 566546003498 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 566546003499 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 566546003500 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 566546003501 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 566546003502 Ligand binding site; other site 566546003503 DXD motif; other site 566546003504 lipoprotein; Provisional; Region: PRK10175 566546003505 secY/secA suppressor protein; Provisional; Region: PRK11467 566546003506 drug efflux system protein MdtG; Provisional; Region: PRK09874 566546003507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546003508 putative substrate translocation pore; other site 566546003509 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 566546003510 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 566546003511 putative acyl-acceptor binding pocket; other site 566546003512 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 566546003513 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 566546003514 active site residue [active] 566546003515 hypothetical protein; Provisional; Region: PRK03757 566546003516 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 566546003517 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 566546003518 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 566546003519 hydroxyglutarate oxidase; Provisional; Region: PRK11728 566546003520 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 566546003521 DNA damage-inducible protein I; Provisional; Region: PRK10597 566546003522 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 566546003523 active site 566546003524 substrate binding pocket [chemical binding]; other site 566546003525 dimer interface [polypeptide binding]; other site 566546003526 lipoprotein; Provisional; Region: PRK10598 566546003527 glutaredoxin 2; Provisional; Region: PRK10387 566546003528 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 566546003529 C-terminal domain interface [polypeptide binding]; other site 566546003530 GSH binding site (G-site) [chemical binding]; other site 566546003531 catalytic residues [active] 566546003532 putative dimer interface [polypeptide binding]; other site 566546003533 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 566546003534 N-terminal domain interface [polypeptide binding]; other site 566546003535 multidrug resistance protein MdtH; Provisional; Region: PRK11646 566546003536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546003537 putative substrate translocation pore; other site 566546003538 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 566546003539 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 566546003540 hypothetical protein; Provisional; Region: PRK11239 566546003541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 566546003542 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 566546003543 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 566546003544 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 566546003545 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 566546003546 MviN-like protein; Region: MVIN; pfam03023 566546003547 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 566546003548 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 566546003549 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 566546003550 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 566546003551 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 566546003552 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 566546003553 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 566546003554 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 566546003555 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 566546003556 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 566546003557 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 566546003558 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 566546003559 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 566546003560 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 566546003561 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 566546003562 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 566546003563 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 566546003564 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 566546003565 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 566546003566 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 566546003567 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 566546003568 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 566546003569 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 566546003570 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 566546003571 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 566546003572 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 566546003573 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 566546003574 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 566546003575 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 566546003576 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 566546003577 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 566546003578 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 566546003579 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 566546003580 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 566546003581 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 566546003582 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 566546003583 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 566546003584 homodimer interface [polypeptide binding]; other site 566546003585 oligonucleotide binding site [chemical binding]; other site 566546003586 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 566546003587 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 566546003588 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 566546003589 RNA binding surface [nucleotide binding]; other site 566546003590 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 566546003591 active site 566546003592 Maf-like protein; Region: Maf; pfam02545 566546003593 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 566546003594 active site 566546003595 dimer interface [polypeptide binding]; other site 566546003596 hypothetical protein; Provisional; Region: PRK11193 566546003597 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 566546003598 putative phosphate acyltransferase; Provisional; Region: PRK05331 566546003599 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 566546003600 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 566546003601 dimer interface [polypeptide binding]; other site 566546003602 active site 566546003603 CoA binding pocket [chemical binding]; other site 566546003604 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 566546003605 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 566546003606 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 566546003607 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 566546003608 NAD(P) binding site [chemical binding]; other site 566546003609 homotetramer interface [polypeptide binding]; other site 566546003610 homodimer interface [polypeptide binding]; other site 566546003611 active site 566546003612 acyl carrier protein; Provisional; Region: acpP; PRK00982 566546003613 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 566546003614 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 566546003615 dimer interface [polypeptide binding]; other site 566546003616 active site 566546003617 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 566546003618 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 566546003619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546003620 catalytic residue [active] 566546003621 conserved hypothetical protein, YceG family; Region: TIGR00247 566546003622 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 566546003623 dimerization interface [polypeptide binding]; other site 566546003624 thymidylate kinase; Validated; Region: tmk; PRK00698 566546003625 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 566546003626 TMP-binding site; other site 566546003627 ATP-binding site [chemical binding]; other site 566546003628 DNA polymerase III subunit delta'; Validated; Region: PRK07993 566546003629 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 566546003630 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 566546003631 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 566546003632 active site 566546003633 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 566546003634 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 566546003635 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 566546003636 active site turn [active] 566546003637 phosphorylation site [posttranslational modification] 566546003638 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 566546003639 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 566546003640 N-terminal plug; other site 566546003641 ligand-binding site [chemical binding]; other site 566546003642 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 566546003643 nucleotide binding site/active site [active] 566546003644 HIT family signature motif; other site 566546003645 catalytic residue [active] 566546003646 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 566546003647 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 566546003648 putative dimer interface [polypeptide binding]; other site 566546003649 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 566546003650 thiamine kinase; Region: ycfN_thiK; TIGR02721 566546003651 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 566546003652 active site 566546003653 substrate binding site [chemical binding]; other site 566546003654 ATP binding site [chemical binding]; other site 566546003655 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 566546003656 beta-hexosaminidase; Provisional; Region: PRK05337 566546003657 hypothetical protein; Provisional; Region: PRK04940 566546003658 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 566546003659 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 566546003660 hypothetical protein; Provisional; Region: PRK11280 566546003661 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 566546003662 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 566546003663 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 566546003664 L,D-transpeptidase; Provisional; Region: PRK10260 566546003665 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 566546003666 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 566546003667 transcription-repair coupling factor; Provisional; Region: PRK10689 566546003668 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 566546003669 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 566546003670 ATP binding site [chemical binding]; other site 566546003671 putative Mg++ binding site [ion binding]; other site 566546003672 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 566546003673 nucleotide binding region [chemical binding]; other site 566546003674 ATP-binding site [chemical binding]; other site 566546003675 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 566546003676 Predicted membrane protein [Function unknown]; Region: COG4763 566546003677 Acyltransferase family; Region: Acyl_transf_3; pfam01757 566546003678 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 566546003679 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 566546003680 FtsX-like permease family; Region: FtsX; pfam02687 566546003681 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 566546003682 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 566546003683 Walker A/P-loop; other site 566546003684 ATP binding site [chemical binding]; other site 566546003685 Q-loop/lid; other site 566546003686 ABC transporter signature motif; other site 566546003687 Walker B; other site 566546003688 D-loop; other site 566546003689 H-loop/switch region; other site 566546003690 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 566546003691 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 566546003692 FtsX-like permease family; Region: FtsX; pfam02687 566546003693 fructokinase; Reviewed; Region: PRK09557 566546003694 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 566546003695 nucleotide binding site [chemical binding]; other site 566546003696 NAD-dependent deacetylase; Provisional; Region: PRK00481 566546003697 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 566546003698 NAD+ binding site [chemical binding]; other site 566546003699 substrate binding site [chemical binding]; other site 566546003700 Zn binding site [ion binding]; other site 566546003701 Repair protein; Region: Repair_PSII; cl01535 566546003702 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 566546003703 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 566546003704 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 566546003705 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 566546003706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546003707 dimer interface [polypeptide binding]; other site 566546003708 conserved gate region; other site 566546003709 putative PBP binding loops; other site 566546003710 ABC-ATPase subunit interface; other site 566546003711 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 566546003712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546003713 dimer interface [polypeptide binding]; other site 566546003714 conserved gate region; other site 566546003715 putative PBP binding loops; other site 566546003716 ABC-ATPase subunit interface; other site 566546003717 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 566546003718 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 566546003719 Walker A/P-loop; other site 566546003720 ATP binding site [chemical binding]; other site 566546003721 Q-loop/lid; other site 566546003722 ABC transporter signature motif; other site 566546003723 Walker B; other site 566546003724 D-loop; other site 566546003725 H-loop/switch region; other site 566546003726 TOBE domain; Region: TOBE_2; pfam08402 566546003727 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 566546003728 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 566546003729 metal binding site [ion binding]; metal-binding site 566546003730 dimer interface [polypeptide binding]; other site 566546003731 Uncharacterized conserved protein [Function unknown]; Region: COG2850 566546003732 Cupin-like domain; Region: Cupin_8; pfam13621 566546003733 sensor protein PhoQ; Provisional; Region: PRK10815 566546003734 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 566546003735 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 566546003736 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 566546003737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546003738 ATP binding site [chemical binding]; other site 566546003739 Mg2+ binding site [ion binding]; other site 566546003740 G-X-G motif; other site 566546003741 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 566546003742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546003743 active site 566546003744 phosphorylation site [posttranslational modification] 566546003745 intermolecular recognition site; other site 566546003746 dimerization interface [polypeptide binding]; other site 566546003747 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 566546003748 DNA binding site [nucleotide binding] 566546003749 adenylosuccinate lyase; Provisional; Region: PRK09285 566546003750 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 566546003751 tetramer interface [polypeptide binding]; other site 566546003752 active site 566546003753 putative lysogenization regulator; Reviewed; Region: PRK00218 566546003754 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 566546003755 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 566546003756 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 566546003757 nudix motif; other site 566546003758 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 566546003759 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 566546003760 probable active site [active] 566546003761 isocitrate dehydrogenase; Validated; Region: PRK07362 566546003762 isocitrate dehydrogenase; Reviewed; Region: PRK07006 566546003763 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 566546003764 transcriptional regulator MirA; Provisional; Region: PRK15043 566546003765 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 566546003766 DNA binding residues [nucleotide binding] 566546003767 Sensors of blue-light using FAD; Region: BLUF; smart01034 566546003768 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 566546003769 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 566546003770 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 566546003771 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 566546003772 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 566546003773 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 566546003774 pseudogene, putative outer membrane autotransporter 566546003775 pseudogene, conserved hypothetical protein 566546003776 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 566546003777 cell division inhibitor MinD; Provisional; Region: PRK10818 566546003778 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 566546003779 Switch I; other site 566546003780 Switch II; other site 566546003781 septum formation inhibitor; Reviewed; Region: minC; PRK03511 566546003782 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 566546003783 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 566546003784 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 566546003785 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 566546003786 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 566546003787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 566546003788 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 566546003789 hypothetical protein; Provisional; Region: PRK10691 566546003790 hypothetical protein; Provisional; Region: PRK05170 566546003791 pseudogene, hemolysin E fragment 566546003792 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 566546003793 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 566546003794 Catalytic site [active] 566546003795 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 566546003796 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 566546003797 active site 566546003798 DNA binding site [nucleotide binding] 566546003799 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 566546003800 disulfide bond formation protein B; Provisional; Region: PRK01749 566546003801 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 566546003802 transmembrane helices; other site 566546003803 fatty acid metabolism regulator; Provisional; Region: PRK04984 566546003804 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 566546003805 DNA-binding site [nucleotide binding]; DNA binding site 566546003806 FadR C-terminal domain; Region: FadR_C; pfam07840 566546003807 SpoVR family protein; Provisional; Region: PRK11767 566546003808 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 566546003809 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 566546003810 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 566546003811 alanine racemase; Reviewed; Region: dadX; PRK03646 566546003812 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 566546003813 active site 566546003814 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 566546003815 substrate binding site [chemical binding]; other site 566546003816 catalytic residues [active] 566546003817 dimer interface [polypeptide binding]; other site 566546003818 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 566546003819 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 566546003820 TrkA-C domain; Region: TrkA_C; pfam02080 566546003821 Transporter associated domain; Region: CorC_HlyC; smart01091 566546003822 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 566546003823 dimer interface [polypeptide binding]; other site 566546003824 catalytic triad [active] 566546003825 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 566546003826 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 566546003827 N-acetyl-D-glucosamine binding site [chemical binding]; other site 566546003828 catalytic residue [active] 566546003829 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 566546003830 Flagellar regulator YcgR; Region: YcgR; pfam07317 566546003831 PilZ domain; Region: PilZ; pfam07238 566546003832 hypothetical protein; Provisional; Region: PRK10457 566546003833 trehalase; Provisional; Region: treA; PRK13271 566546003834 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 566546003835 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 566546003836 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 566546003837 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 566546003838 dimerization domain swap beta strand [polypeptide binding]; other site 566546003839 regulatory protein interface [polypeptide binding]; other site 566546003840 active site 566546003841 regulatory phosphorylation site [posttranslational modification]; other site 566546003842 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 566546003843 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 566546003844 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 566546003845 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 566546003846 Dak1 domain; Region: Dak1; pfam02733 566546003847 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 566546003848 PAS domain; Region: PAS; smart00091 566546003849 putative active site [active] 566546003850 heme pocket [chemical binding]; other site 566546003851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546003852 Walker A motif; other site 566546003853 ATP binding site [chemical binding]; other site 566546003854 Walker B motif; other site 566546003855 arginine finger; other site 566546003856 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 566546003857 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 566546003858 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 566546003859 Autotransporter beta-domain; Region: Autotransporter; pfam03797 566546003860 GTP-binding protein YchF; Reviewed; Region: PRK09601 566546003861 YchF GTPase; Region: YchF; cd01900 566546003862 G1 box; other site 566546003863 GTP/Mg2+ binding site [chemical binding]; other site 566546003864 Switch I region; other site 566546003865 G2 box; other site 566546003866 Switch II region; other site 566546003867 G3 box; other site 566546003868 G4 box; other site 566546003869 G5 box; other site 566546003870 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 566546003871 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 566546003872 putative active site [active] 566546003873 catalytic residue [active] 566546003874 hypothetical protein; Provisional; Region: PRK10692 566546003875 putative transporter; Provisional; Region: PRK11660 566546003876 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 566546003877 Sulfate transporter family; Region: Sulfate_transp; pfam00916 566546003878 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 566546003879 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 566546003880 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 566546003881 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 566546003882 active site 566546003883 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 566546003884 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 566546003885 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 566546003886 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 566546003887 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 566546003888 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 566546003889 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 566546003890 tRNA; other site 566546003891 putative tRNA binding site [nucleotide binding]; other site 566546003892 putative NADP binding site [chemical binding]; other site 566546003893 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 566546003894 peptide chain release factor 1; Validated; Region: prfA; PRK00591 566546003895 This domain is found in peptide chain release factors; Region: PCRF; smart00937 566546003896 RF-1 domain; Region: RF-1; pfam00472 566546003897 HemK family putative methylases; Region: hemK_fam; TIGR00536 566546003898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546003899 hypothetical protein; Provisional; Region: PRK10278 566546003900 hypothetical protein; Provisional; Region: PRK10941 566546003901 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 566546003902 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 566546003903 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 566546003904 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 566546003905 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 566546003906 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 566546003907 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 566546003908 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 566546003909 cation transport regulator; Reviewed; Region: chaB; PRK09582 566546003910 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 566546003911 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 566546003912 putative active site pocket [active] 566546003913 dimerization interface [polypeptide binding]; other site 566546003914 putative catalytic residue [active] 566546003915 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 566546003916 putative invasin; Provisional; Region: PRK10177 566546003917 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 566546003918 transcriptional regulator NarL; Provisional; Region: PRK10651 566546003919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546003920 active site 566546003921 phosphorylation site [posttranslational modification] 566546003922 intermolecular recognition site; other site 566546003923 dimerization interface [polypeptide binding]; other site 566546003924 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 566546003925 DNA binding residues [nucleotide binding] 566546003926 dimerization interface [polypeptide binding]; other site 566546003927 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 566546003928 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 566546003929 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 566546003930 dimerization interface [polypeptide binding]; other site 566546003931 Histidine kinase; Region: HisKA_3; pfam07730 566546003932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546003933 ATP binding site [chemical binding]; other site 566546003934 Mg2+ binding site [ion binding]; other site 566546003935 G-X-G motif; other site 566546003936 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 566546003937 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 566546003938 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 566546003939 [4Fe-4S] binding site [ion binding]; other site 566546003940 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 566546003941 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 566546003942 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 566546003943 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 566546003944 molybdopterin cofactor binding site; other site 566546003945 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 566546003946 4Fe-4S binding domain; Region: Fer4; cl02805 566546003947 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 566546003948 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 566546003949 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 566546003950 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 566546003951 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 566546003952 putative active site [active] 566546003953 putative substrate binding site [chemical binding]; other site 566546003954 putative cosubstrate binding site; other site 566546003955 catalytic site [active] 566546003956 SEC-C motif; Region: SEC-C; pfam02810 566546003957 hypothetical protein; Provisional; Region: PRK04233 566546003958 hypothetical protein; Provisional; Region: PRK10279 566546003959 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 566546003960 active site 566546003961 nucleophile elbow; other site 566546003962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546003963 active site 566546003964 response regulator of RpoS; Provisional; Region: PRK10693 566546003965 phosphorylation site [posttranslational modification] 566546003966 intermolecular recognition site; other site 566546003967 dimerization interface [polypeptide binding]; other site 566546003968 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 566546003969 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 566546003970 active site 566546003971 tetramer interface; other site 566546003972 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 566546003973 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 566546003974 thymidine kinase; Provisional; Region: PRK04296 566546003975 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 566546003976 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 566546003977 putative catalytic cysteine [active] 566546003978 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 566546003979 putative active site [active] 566546003980 metal binding site [ion binding]; metal-binding site 566546003981 hypothetical protein; Provisional; Region: PRK11111 566546003982 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 566546003983 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 566546003984 peptide binding site [polypeptide binding]; other site 566546003985 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 566546003986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546003987 dimer interface [polypeptide binding]; other site 566546003988 conserved gate region; other site 566546003989 putative PBP binding loops; other site 566546003990 ABC-ATPase subunit interface; other site 566546003991 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 566546003992 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 566546003993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546003994 dimer interface [polypeptide binding]; other site 566546003995 conserved gate region; other site 566546003996 putative PBP binding loops; other site 566546003997 ABC-ATPase subunit interface; other site 566546003998 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 566546003999 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 566546004000 Walker A/P-loop; other site 566546004001 ATP binding site [chemical binding]; other site 566546004002 Q-loop/lid; other site 566546004003 ABC transporter signature motif; other site 566546004004 Walker B; other site 566546004005 D-loop; other site 566546004006 H-loop/switch region; other site 566546004007 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 566546004008 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 566546004009 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 566546004010 Walker A/P-loop; other site 566546004011 ATP binding site [chemical binding]; other site 566546004012 Q-loop/lid; other site 566546004013 ABC transporter signature motif; other site 566546004014 Walker B; other site 566546004015 D-loop; other site 566546004016 H-loop/switch region; other site 566546004017 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 566546004018 dsDNA-mimic protein; Reviewed; Region: PRK05094 566546004019 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 566546004020 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 566546004021 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 566546004022 putative active site [active] 566546004023 catalytic site [active] 566546004024 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 566546004025 putative active site [active] 566546004026 catalytic site [active] 566546004027 voltage-gated potassium channel; Provisional; Region: PRK10537 566546004028 Ion channel; Region: Ion_trans_2; pfam07885 566546004029 TrkA-N domain; Region: TrkA_N; pfam02254 566546004030 YciI-like protein; Reviewed; Region: PRK11370 566546004031 transport protein TonB; Provisional; Region: PRK10819 566546004032 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 566546004033 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 566546004034 intracellular septation protein A; Reviewed; Region: PRK00259 566546004035 hypothetical protein; Provisional; Region: PRK02868 566546004036 outer membrane protein W; Provisional; Region: PRK10959 566546004037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 566546004038 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 566546004039 dimerization interface [polypeptide binding]; other site 566546004040 metal binding site [ion binding]; metal-binding site 566546004041 General stress protein [General function prediction only]; Region: GsiB; COG3729 566546004042 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 566546004043 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 566546004044 substrate binding site [chemical binding]; other site 566546004045 active site 566546004046 catalytic residues [active] 566546004047 heterodimer interface [polypeptide binding]; other site 566546004048 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 566546004049 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 566546004050 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546004051 catalytic residue [active] 566546004052 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 566546004053 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 566546004054 active site 566546004055 ribulose/triose binding site [chemical binding]; other site 566546004056 phosphate binding site [ion binding]; other site 566546004057 substrate (anthranilate) binding pocket [chemical binding]; other site 566546004058 product (indole) binding pocket [chemical binding]; other site 566546004059 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 566546004060 active site 566546004061 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 566546004062 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 566546004063 glutamine binding [chemical binding]; other site 566546004064 catalytic triad [active] 566546004065 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 566546004066 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 566546004067 anthranilate synthase component I; Provisional; Region: PRK13564 566546004068 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 566546004069 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 566546004070 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 566546004071 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 566546004072 active site 566546004073 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 566546004074 hypothetical protein; Provisional; Region: PRK11630 566546004075 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 566546004076 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 566546004077 RNA binding surface [nucleotide binding]; other site 566546004078 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 566546004079 probable active site [active] 566546004080 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 566546004081 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 566546004082 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 566546004083 homodimer interface [polypeptide binding]; other site 566546004084 Walker A motif; other site 566546004085 ATP binding site [chemical binding]; other site 566546004086 hydroxycobalamin binding site [chemical binding]; other site 566546004087 Walker B motif; other site 566546004088 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 566546004089 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 566546004090 NADP binding site [chemical binding]; other site 566546004091 homodimer interface [polypeptide binding]; other site 566546004092 active site 566546004093 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 566546004094 putative inner membrane peptidase; Provisional; Region: PRK11778 566546004095 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 566546004096 tandem repeat interface [polypeptide binding]; other site 566546004097 oligomer interface [polypeptide binding]; other site 566546004098 active site residues [active] 566546004099 hypothetical protein; Provisional; Region: PRK11037 566546004100 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 566546004101 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 566546004102 active site 566546004103 interdomain interaction site; other site 566546004104 putative metal-binding site [ion binding]; other site 566546004105 nucleotide binding site [chemical binding]; other site 566546004106 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 566546004107 domain I; other site 566546004108 DNA binding groove [nucleotide binding] 566546004109 phosphate binding site [ion binding]; other site 566546004110 domain II; other site 566546004111 domain III; other site 566546004112 nucleotide binding site [chemical binding]; other site 566546004113 catalytic site [active] 566546004114 domain IV; other site 566546004115 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 566546004116 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 566546004117 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 566546004118 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 566546004119 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 566546004120 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546004121 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 566546004122 substrate binding site [chemical binding]; other site 566546004123 putative dimerization interface [polypeptide binding]; other site 566546004124 aconitate hydratase; Validated; Region: PRK09277 566546004125 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 566546004126 substrate binding site [chemical binding]; other site 566546004127 ligand binding site [chemical binding]; other site 566546004128 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 566546004129 substrate binding site [chemical binding]; other site 566546004130 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 566546004131 dimerization interface [polypeptide binding]; other site 566546004132 active site 566546004133 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 566546004134 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 566546004135 active site 566546004136 Predicted membrane protein [Function unknown]; Region: COG3771 566546004137 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 566546004138 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 566546004139 TPR motif; other site 566546004140 binding surface 566546004141 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 566546004142 binding surface 566546004143 TPR motif; other site 566546004144 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 566546004145 active site 566546004146 dimer interface [polypeptide binding]; other site 566546004147 translation initiation factor Sui1; Validated; Region: PRK06824 566546004148 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 566546004149 putative rRNA binding site [nucleotide binding]; other site 566546004150 lipoprotein; Provisional; Region: PRK10540 566546004151 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 566546004152 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 566546004153 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 566546004154 hypothetical protein; Provisional; Region: PRK13658 566546004155 RNase II stability modulator; Provisional; Region: PRK10060 566546004156 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 566546004157 putative active site [active] 566546004158 heme pocket [chemical binding]; other site 566546004159 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 566546004160 metal binding site [ion binding]; metal-binding site 566546004161 active site 566546004162 I-site; other site 566546004163 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 566546004164 exoribonuclease II; Provisional; Region: PRK05054 566546004165 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 566546004166 RNB domain; Region: RNB; pfam00773 566546004167 S1 RNA binding domain; Region: S1; pfam00575 566546004168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 566546004169 Uncharacterized conserved protein [Function unknown]; Region: COG2128 566546004170 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 566546004171 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 566546004172 NAD binding site [chemical binding]; other site 566546004173 homotetramer interface [polypeptide binding]; other site 566546004174 homodimer interface [polypeptide binding]; other site 566546004175 substrate binding site [chemical binding]; other site 566546004176 active site 566546004177 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 566546004178 putative active site [active] 566546004179 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 566546004180 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 566546004181 Walker A/P-loop; other site 566546004182 ATP binding site [chemical binding]; other site 566546004183 Q-loop/lid; other site 566546004184 ABC transporter signature motif; other site 566546004185 Walker B; other site 566546004186 D-loop; other site 566546004187 H-loop/switch region; other site 566546004188 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 566546004189 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 566546004190 Walker A/P-loop; other site 566546004191 ATP binding site [chemical binding]; other site 566546004192 Q-loop/lid; other site 566546004193 ABC transporter signature motif; other site 566546004194 Walker B; other site 566546004195 D-loop; other site 566546004196 H-loop/switch region; other site 566546004197 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 566546004198 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 566546004199 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 566546004200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546004201 dimer interface [polypeptide binding]; other site 566546004202 conserved gate region; other site 566546004203 putative PBP binding loops; other site 566546004204 ABC-ATPase subunit interface; other site 566546004205 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 566546004206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546004207 dimer interface [polypeptide binding]; other site 566546004208 conserved gate region; other site 566546004209 putative PBP binding loops; other site 566546004210 ABC-ATPase subunit interface; other site 566546004211 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 566546004212 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 566546004213 peptide binding site [polypeptide binding]; other site 566546004214 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 566546004215 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 566546004216 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 566546004217 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 566546004218 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 566546004219 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 566546004220 catalytic triad [active] 566546004221 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 566546004222 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 566546004223 non-specific DNA binding site [nucleotide binding]; other site 566546004224 salt bridge; other site 566546004225 sequence-specific DNA binding site [nucleotide binding]; other site 566546004226 Cupin domain; Region: Cupin_2; pfam07883 566546004227 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 566546004228 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 566546004229 NAD(P) binding site [chemical binding]; other site 566546004230 catalytic residues [active] 566546004231 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 566546004232 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 566546004233 4-aminobutyrate transaminase; Provisional; Region: PRK09792 566546004234 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 566546004235 inhibitor-cofactor binding pocket; inhibition site 566546004236 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546004237 catalytic residue [active] 566546004238 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 566546004239 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546004240 Walker A motif; other site 566546004241 ATP binding site [chemical binding]; other site 566546004242 Walker B motif; other site 566546004243 arginine finger; other site 566546004244 phage shock protein PspA; Provisional; Region: PRK10698 566546004245 phage shock protein B; Provisional; Region: pspB; PRK09458 566546004246 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 566546004247 phage shock protein C; Region: phageshock_pspC; TIGR02978 566546004248 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 566546004249 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 566546004250 active site residue [active] 566546004251 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 566546004252 sucrose phosphorylase; Provisional; Region: PRK13840 566546004253 active site 566546004254 homodimer interface [polypeptide binding]; other site 566546004255 catalytic site [active] 566546004256 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 566546004257 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 566546004258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546004259 dimer interface [polypeptide binding]; other site 566546004260 conserved gate region; other site 566546004261 putative PBP binding loops; other site 566546004262 ABC-ATPase subunit interface; other site 566546004263 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 566546004264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546004265 dimer interface [polypeptide binding]; other site 566546004266 conserved gate region; other site 566546004267 putative PBP binding loops; other site 566546004268 ABC-ATPase subunit interface; other site 566546004269 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 566546004270 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 566546004271 putative NAD(P) binding site [chemical binding]; other site 566546004272 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 566546004273 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 566546004274 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 566546004275 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 566546004276 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 566546004277 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 566546004278 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 566546004279 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 566546004280 beta-phosphoglucomutase; Region: bPGM; TIGR01990 566546004281 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 566546004282 motif II; other site 566546004283 pseudogene, putative ATP binding component of transport system 566546004284 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 566546004285 Transcriptional regulators [Transcription]; Region: PurR; COG1609 566546004286 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 566546004287 DNA binding site [nucleotide binding] 566546004288 domain linker motif; other site 566546004289 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 566546004290 putative dimerization interface [polypeptide binding]; other site 566546004291 putative ligand binding site [chemical binding]; other site 566546004292 Predicted ATPase [General function prediction only]; Region: COG3106 566546004293 Predicted membrane protein [Function unknown]; Region: COG3768 566546004294 TIGR01620 family protein; Region: hyp_HI0043 566546004295 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 566546004296 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 566546004297 putative aromatic amino acid binding site; other site 566546004298 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546004299 Walker A motif; other site 566546004300 ATP binding site [chemical binding]; other site 566546004301 Walker B motif; other site 566546004302 arginine finger; other site 566546004303 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 566546004304 dimer interface [polypeptide binding]; other site 566546004305 catalytic triad [active] 566546004306 peroxidatic and resolving cysteines [active] 566546004307 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 566546004308 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 566546004309 active site 566546004310 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 566546004311 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 566546004312 putative active site [active] 566546004313 Zn binding site [ion binding]; other site 566546004314 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 566546004315 NADH(P)-binding; Region: NAD_binding_10; pfam13460 566546004316 putative NAD(P) binding site [chemical binding]; other site 566546004317 pseudogene, predicted hydrolase 566546004318 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 566546004319 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 566546004320 Transcriptional regulator [Transcription]; Region: LysR; COG0583 566546004321 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546004322 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 566546004323 putative effector binding pocket; other site 566546004324 putative dimerization interface [polypeptide binding]; other site 566546004325 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 566546004326 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 566546004327 peptide binding site [polypeptide binding]; other site 566546004328 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 566546004329 Mechanosensitive ion channel; Region: MS_channel; pfam00924 566546004330 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 566546004331 universal stress protein UspE; Provisional; Region: PRK11175 566546004332 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 566546004333 Ligand Binding Site [chemical binding]; other site 566546004334 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 566546004335 Ligand Binding Site [chemical binding]; other site 566546004336 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 566546004337 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 566546004338 ligand binding site [chemical binding]; other site 566546004339 flexible hinge region; other site 566546004340 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 566546004341 putative switch regulator; other site 566546004342 non-specific DNA interactions [nucleotide binding]; other site 566546004343 DNA binding site [nucleotide binding] 566546004344 sequence specific DNA binding site [nucleotide binding]; other site 566546004345 putative cAMP binding site [chemical binding]; other site 566546004346 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 566546004347 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 566546004348 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 566546004349 DNA binding site [nucleotide binding] 566546004350 active site 566546004351 putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339 566546004352 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 566546004353 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 566546004354 amidohydrolase; Region: amidohydrolases; TIGR01891 566546004355 putative metal binding site [ion binding]; other site 566546004356 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 566546004357 amidohydrolase; Region: amidohydrolases; TIGR01891 566546004358 putative metal binding site [ion binding]; other site 566546004359 dimer interface [polypeptide binding]; other site 566546004360 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 566546004361 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546004362 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 566546004363 putative substrate binding pocket [chemical binding]; other site 566546004364 putative dimerization interface [polypeptide binding]; other site 566546004365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 566546004366 Smr domain; Region: Smr; pfam01713 566546004367 PAS domain S-box; Region: sensory_box; TIGR00229 566546004368 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 566546004369 putative active site [active] 566546004370 heme pocket [chemical binding]; other site 566546004371 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 566546004372 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 566546004373 metal binding site [ion binding]; metal-binding site 566546004374 active site 566546004375 I-site; other site 566546004376 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 566546004377 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 566546004378 Cl binding site [ion binding]; other site 566546004379 oligomer interface [polypeptide binding]; other site 566546004380 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 566546004381 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 566546004382 ATP binding site [chemical binding]; other site 566546004383 Mg++ binding site [ion binding]; other site 566546004384 motif III; other site 566546004385 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 566546004386 nucleotide binding region [chemical binding]; other site 566546004387 ATP-binding site [chemical binding]; other site 566546004388 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 566546004389 putative RNA binding site [nucleotide binding]; other site 566546004390 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 566546004391 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 566546004392 Ligand Binding Site [chemical binding]; other site 566546004393 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 566546004394 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 566546004395 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 566546004396 Int/Topo IB signature motif; other site 566546004397 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 566546004398 hypothetical protein; Provisional; Region: PRK09750 566546004399 recombination and repair protein RecT; Reviewed; Region: recT; PRK09846 566546004400 exonuclease VIII; Reviewed; Region: PRK09709 566546004401 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 566546004402 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 566546004403 hypothetical protein; Reviewed; Region: PRK09790 566546004404 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 566546004405 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 566546004406 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 566546004407 non-specific DNA binding site [nucleotide binding]; other site 566546004408 salt bridge; other site 566546004409 transcriptional repressor DicA; Reviewed; Region: PRK09706 566546004410 sequence-specific DNA binding site [nucleotide binding]; other site 566546004411 Helix-turn-helix domain; Region: HTH_17; cl17695 566546004412 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 566546004413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3756 566546004414 primosomal protein DnaI; Provisional; Region: PRK02854 566546004415 putative replication protein; Provisional; Region: PRK12377 566546004416 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546004417 Walker A motif; other site 566546004418 ATP binding site [chemical binding]; other site 566546004419 Walker B motif; other site 566546004420 arginine finger; other site 566546004421 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 566546004422 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 566546004423 Protein of unknown function DUF262; Region: DUF262; pfam03235 566546004424 Uncharacterized conserved protein [Function unknown]; Region: COG4938 566546004425 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 566546004426 Hok/gef family; Region: HOK_GEF; pfam01848 566546004427 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 566546004428 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 566546004429 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 566546004430 Protein of unknown function (DUF754); Region: DUF754; pfam05449 566546004431 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 566546004432 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 566546004433 ParB-like nuclease domain; Region: ParBc; pfam02195 566546004434 Terminase small subunit; Region: Terminase_2; cl01513 566546004435 Terminase-like family; Region: Terminase_6; pfam03237 566546004436 large terminase protein; Provisional; Region: 17; PHA02533 566546004437 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 566546004438 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 566546004439 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 566546004440 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 566546004441 N-acetyl-D-glucosamine binding site [chemical binding]; other site 566546004442 catalytic residue [active] 566546004443 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 566546004444 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 566546004445 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 566546004446 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 566546004447 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 566546004448 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 566546004449 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 566546004450 Ligand Binding Site [chemical binding]; other site 566546004451 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 566546004452 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 566546004453 trimer interface [polypeptide binding]; other site 566546004454 eyelet of channel; other site 566546004455 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 566546004456 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 566546004457 dimer interface [polypeptide binding]; other site 566546004458 PYR/PP interface [polypeptide binding]; other site 566546004459 TPP binding site [chemical binding]; other site 566546004460 substrate binding site [chemical binding]; other site 566546004461 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 566546004462 Domain of unknown function; Region: EKR; smart00890 566546004463 4Fe-4S binding domain; Region: Fer4_6; pfam12837 566546004464 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 566546004465 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 566546004466 TPP-binding site [chemical binding]; other site 566546004467 dimer interface [polypeptide binding]; other site 566546004468 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 566546004469 Domain of unknown function (DUF333); Region: DUF333; pfam03891 566546004470 heat-inducible protein; Provisional; Region: PRK10449 566546004471 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 566546004472 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 566546004473 putative ligand binding site [chemical binding]; other site 566546004474 putative NAD binding site [chemical binding]; other site 566546004475 catalytic site [active] 566546004476 hypothetical protein; Provisional; Region: PRK10695 566546004477 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 566546004478 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 566546004479 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 566546004480 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546004481 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 566546004482 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 566546004483 NAD(P) binding site [chemical binding]; other site 566546004484 catalytic residues [active] 566546004485 tyramine oxidase; Provisional; Region: tynA; PRK14696 566546004486 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 566546004487 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 566546004488 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 566546004489 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 566546004490 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 566546004491 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 566546004492 substrate binding site [chemical binding]; other site 566546004493 dimer interface [polypeptide binding]; other site 566546004494 NADP binding site [chemical binding]; other site 566546004495 catalytic residues [active] 566546004496 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 566546004497 substrate binding site [chemical binding]; other site 566546004498 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 566546004499 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 566546004500 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 566546004501 phenylacetate-CoA oxygenase, PaaI subunit; Region: PA_CoA_Oxy3; TIGR02158 566546004502 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 566546004503 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 566546004504 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 566546004505 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 566546004506 FAD binding pocket [chemical binding]; other site 566546004507 FAD binding motif [chemical binding]; other site 566546004508 phosphate binding motif [ion binding]; other site 566546004509 beta-alpha-beta structure motif; other site 566546004510 NAD(p) ribose binding residues [chemical binding]; other site 566546004511 NAD binding pocket [chemical binding]; other site 566546004512 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 566546004513 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 566546004514 catalytic loop [active] 566546004515 iron binding site [ion binding]; other site 566546004516 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 566546004517 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 566546004518 substrate binding site [chemical binding]; other site 566546004519 oxyanion hole (OAH) forming residues; other site 566546004520 trimer interface [polypeptide binding]; other site 566546004521 enoyl-CoA hydratase; Provisional; Region: PRK08140 566546004522 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 566546004523 substrate binding site [chemical binding]; other site 566546004524 oxyanion hole (OAH) forming residues; other site 566546004525 trimer interface [polypeptide binding]; other site 566546004526 3-hydroxyacyl-CoA dehydrogenase PaaC; Region: PaaC-3OHAcCoADH; TIGR02279 566546004527 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 566546004528 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 566546004529 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 566546004530 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 566546004531 CoenzymeA binding site [chemical binding]; other site 566546004532 subunit interaction site [polypeptide binding]; other site 566546004533 PHB binding site; other site 566546004534 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 566546004535 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 566546004536 dimer interface [polypeptide binding]; other site 566546004537 active site 566546004538 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 566546004539 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 566546004540 active site 566546004541 AMP binding site [chemical binding]; other site 566546004542 homodimer interface [polypeptide binding]; other site 566546004543 acyl-activating enzyme (AAE) consensus motif; other site 566546004544 CoA binding site [chemical binding]; other site 566546004545 PaaX-like protein; Region: PaaX; pfam07848 566546004546 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 566546004547 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 566546004548 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 566546004549 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 566546004550 putative trimer interface [polypeptide binding]; other site 566546004551 putative metal binding site [ion binding]; other site 566546004552 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 566546004553 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 566546004554 active site 566546004555 catalytic tetrad [active] 566546004556 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 566546004557 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 566546004558 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 566546004559 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 566546004560 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 566546004561 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 566546004562 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 566546004563 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546004564 S-adenosylmethionine binding site [chemical binding]; other site 566546004565 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 566546004566 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 566546004567 active site 566546004568 Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or...; Region: DSPc; cd00127 566546004569 active site 566546004570 catalytic residues [active] 566546004571 azoreductase; Reviewed; Region: PRK00170 566546004572 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 566546004573 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 566546004574 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 566546004575 ATP binding site [chemical binding]; other site 566546004576 putative Mg++ binding site [ion binding]; other site 566546004577 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 566546004578 nucleotide binding region [chemical binding]; other site 566546004579 ATP-binding site [chemical binding]; other site 566546004580 Helicase associated domain (HA2); Region: HA2; pfam04408 566546004581 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 566546004582 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 566546004583 Uncharacterized conserved protein [Function unknown]; Region: COG1434 566546004584 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 566546004585 putative active site [active] 566546004586 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 566546004587 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 566546004588 NAD binding site [chemical binding]; other site 566546004589 catalytic residues [active] 566546004590 substrate binding site [chemical binding]; other site 566546004591 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 566546004592 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 566546004593 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 566546004594 cytochrome b561; Provisional; Region: PRK11513 566546004595 hypothetical protein; Provisional; Region: PRK10040 566546004596 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 566546004597 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 566546004598 dimer interface [polypeptide binding]; other site 566546004599 ligand binding site [chemical binding]; other site 566546004600 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 566546004601 dimerization interface [polypeptide binding]; other site 566546004602 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 566546004603 dimer interface [polypeptide binding]; other site 566546004604 putative CheW interface [polypeptide binding]; other site 566546004605 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 566546004606 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546004607 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 566546004608 dimerization interface [polypeptide binding]; other site 566546004609 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 566546004610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 566546004611 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 566546004612 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 566546004613 hypothetical protein; Provisional; Region: PRK11415 566546004614 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 566546004615 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 566546004616 Coenzyme A binding pocket [chemical binding]; other site 566546004617 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 566546004618 putative trimer interface [polypeptide binding]; other site 566546004619 putative CoA binding site [chemical binding]; other site 566546004620 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 566546004621 putative trimer interface [polypeptide binding]; other site 566546004622 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 566546004623 putative CoA binding site [chemical binding]; other site 566546004624 putative trimer interface [polypeptide binding]; other site 566546004625 putative CoA binding site [chemical binding]; other site 566546004626 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 566546004627 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 566546004628 gating phenylalanine in ion channel; other site 566546004629 tellurite resistance protein TehB; Provisional; Region: PRK11207 566546004630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546004631 S-adenosylmethionine binding site [chemical binding]; other site 566546004632 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 566546004633 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 566546004634 Probable transposase; Region: OrfB_IS605; pfam01385 566546004635 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 566546004636 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 566546004637 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 566546004638 benzoate transporter; Region: benE; TIGR00843 566546004639 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 566546004640 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 566546004641 non-specific DNA binding site [nucleotide binding]; other site 566546004642 salt bridge; other site 566546004643 sequence-specific DNA binding site [nucleotide binding]; other site 566546004644 Cupin domain; Region: Cupin_2; pfam07883 566546004645 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 566546004646 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 566546004647 Peptidase family U32; Region: Peptidase_U32; pfam01136 566546004648 Collagenase; Region: DUF3656; pfam12392 566546004649 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 566546004650 YcfA-like protein; Region: YcfA; pfam07927 566546004651 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 566546004652 Helix-turn-helix; Region: HTH_3; pfam01381 566546004653 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 566546004654 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 566546004655 DNA-binding site [nucleotide binding]; DNA binding site 566546004656 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 566546004657 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546004658 homodimer interface [polypeptide binding]; other site 566546004659 catalytic residue [active] 566546004660 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 566546004661 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 566546004662 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 566546004663 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 566546004664 Walker A/P-loop; other site 566546004665 ATP binding site [chemical binding]; other site 566546004666 Q-loop/lid; other site 566546004667 ABC transporter signature motif; other site 566546004668 Walker B; other site 566546004669 D-loop; other site 566546004670 H-loop/switch region; other site 566546004671 TOBE domain; Region: TOBE_2; pfam08402 566546004672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546004673 dimer interface [polypeptide binding]; other site 566546004674 conserved gate region; other site 566546004675 putative PBP binding loops; other site 566546004676 ABC-ATPase subunit interface; other site 566546004677 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 566546004678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546004679 ABC-ATPase subunit interface; other site 566546004680 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 566546004681 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 566546004682 tetrameric interface [polypeptide binding]; other site 566546004683 NAD binding site [chemical binding]; other site 566546004684 catalytic residues [active] 566546004685 substrate binding site [chemical binding]; other site 566546004686 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 566546004687 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 566546004688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 566546004689 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 566546004690 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 566546004691 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 566546004692 Prostaglandin dehydrogenases; Region: PGDH; cd05288 566546004693 NAD(P) binding site [chemical binding]; other site 566546004694 substrate binding site [chemical binding]; other site 566546004695 dimer interface [polypeptide binding]; other site 566546004696 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 566546004697 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 566546004698 DNA-binding site [nucleotide binding]; DNA binding site 566546004699 FCD domain; Region: FCD; pfam07729 566546004700 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 566546004701 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 566546004702 N-terminal plug; other site 566546004703 ligand-binding site [chemical binding]; other site 566546004704 PQQ-like domain; Region: PQQ_2; pfam13360 566546004705 L-asparagine permease; Provisional; Region: PRK15049 566546004706 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 566546004707 C-terminal domain interface [polypeptide binding]; other site 566546004708 GSH binding site (G-site) [chemical binding]; other site 566546004709 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 566546004710 dimer interface [polypeptide binding]; other site 566546004711 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 566546004712 dimer interface [polypeptide binding]; other site 566546004713 N-terminal domain interface [polypeptide binding]; other site 566546004714 substrate binding pocket (H-site) [chemical binding]; other site 566546004715 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 566546004716 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 566546004717 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 566546004718 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 566546004719 PAAR motif; Region: PAAR_motif; cl15808 566546004720 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 566546004721 RHS Repeat; Region: RHS_repeat; pfam05593 566546004722 RHS Repeat; Region: RHS_repeat; pfam05593 566546004723 RHS Repeat; Region: RHS_repeat; pfam05593 566546004724 RHS Repeat; Region: RHS_repeat; pfam05593 566546004725 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 566546004726 RHS Repeat; Region: RHS_repeat; pfam05593 566546004727 RHS Repeat; Region: RHS_repeat; pfam05593 566546004728 RHS protein; Region: RHS; pfam03527 566546004729 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 566546004730 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 566546004731 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 566546004732 Transposase [DNA replication, recombination, and repair]; Region: COG5433 566546004733 Transposase [DNA replication, recombination, and repair]; Region: COG5433 566546004734 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 566546004735 active site 1 [active] 566546004736 dimer interface [polypeptide binding]; other site 566546004737 hexamer interface [polypeptide binding]; other site 566546004738 active site 2 [active] 566546004739 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 566546004740 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 566546004741 hypothetical protein; Provisional; Region: PRK10281 566546004742 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 566546004743 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 566546004744 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 566546004745 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 566546004746 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 566546004747 [4Fe-4S] binding site [ion binding]; other site 566546004748 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 566546004749 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 566546004750 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 566546004751 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 566546004752 molybdopterin cofactor binding site; other site 566546004753 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 566546004754 pseudogene, predicted lipoprotein 566546004755 aromatic amino acid exporter; Provisional; Region: PRK11689 566546004756 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 566546004757 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 566546004758 [4Fe-4S] binding site [ion binding]; other site 566546004759 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 566546004760 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 566546004761 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 566546004762 molybdopterin cofactor binding site; other site 566546004763 pseudogene, truncated formate dehydrogenase-N, alpha subunit, nitrate-inducible 566546004764 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 566546004765 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 566546004766 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 566546004767 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 566546004768 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 566546004769 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 566546004770 non-specific DNA binding site [nucleotide binding]; other site 566546004771 salt bridge; other site 566546004772 sequence-specific DNA binding site [nucleotide binding]; other site 566546004773 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 566546004774 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 566546004775 NAD binding site [chemical binding]; other site 566546004776 substrate binding site [chemical binding]; other site 566546004777 catalytic Zn binding site [ion binding]; other site 566546004778 tetramer interface [polypeptide binding]; other site 566546004779 structural Zn binding site [ion binding]; other site 566546004780 malate dehydrogenase; Provisional; Region: PRK13529 566546004781 Malic enzyme, N-terminal domain; Region: malic; pfam00390 566546004782 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 566546004783 NAD(P) binding site [chemical binding]; other site 566546004784 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 566546004785 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 566546004786 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 566546004787 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 566546004788 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 566546004789 Walker A/P-loop; other site 566546004790 ATP binding site [chemical binding]; other site 566546004791 Q-loop/lid; other site 566546004792 ABC transporter signature motif; other site 566546004793 Walker B; other site 566546004794 D-loop; other site 566546004795 H-loop/switch region; other site 566546004796 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 566546004797 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 566546004798 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 566546004799 Walker A/P-loop; other site 566546004800 ATP binding site [chemical binding]; other site 566546004801 Q-loop/lid; other site 566546004802 ABC transporter signature motif; other site 566546004803 Walker B; other site 566546004804 D-loop; other site 566546004805 H-loop/switch region; other site 566546004806 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 566546004807 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 566546004808 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 566546004809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546004810 dimer interface [polypeptide binding]; other site 566546004811 conserved gate region; other site 566546004812 putative PBP binding loops; other site 566546004813 ABC-ATPase subunit interface; other site 566546004814 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 566546004815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546004816 dimer interface [polypeptide binding]; other site 566546004817 conserved gate region; other site 566546004818 putative PBP binding loops; other site 566546004819 ABC-ATPase subunit interface; other site 566546004820 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 566546004821 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 566546004822 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 566546004823 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 566546004824 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 566546004825 putative active site [active] 566546004826 heme pocket [chemical binding]; other site 566546004827 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 566546004828 putative active site [active] 566546004829 heme pocket [chemical binding]; other site 566546004830 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 566546004831 metal binding site [ion binding]; metal-binding site 566546004832 active site 566546004833 I-site; other site 566546004834 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 566546004835 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 566546004836 heme-binding site [chemical binding]; other site 566546004837 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 566546004838 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 566546004839 metal binding site [ion binding]; metal-binding site 566546004840 active site 566546004841 I-site; other site 566546004842 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 566546004843 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 566546004844 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 566546004845 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 566546004846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546004847 catalytic residue [active] 566546004848 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 566546004849 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 566546004850 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 566546004851 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 566546004852 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 566546004853 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 566546004854 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 566546004855 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 566546004856 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 566546004857 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 566546004858 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 566546004859 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 566546004860 FeS/SAM binding site; other site 566546004861 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 566546004862 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 566546004863 Sulfatase; Region: Sulfatase; pfam00884 566546004864 transcriptional regulator YdeO; Provisional; Region: PRK09940 566546004865 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546004866 putative oxidoreductase; Provisional; Region: PRK09939 566546004867 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 566546004868 putative molybdopterin cofactor binding site [chemical binding]; other site 566546004869 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 566546004870 putative molybdopterin cofactor binding site; other site 566546004871 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 566546004872 mannosyl binding site [chemical binding]; other site 566546004873 Fimbrial protein; Region: Fimbrial; pfam00419 566546004874 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 566546004875 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 566546004876 pseudogene, fimbrial biogenesis outer membrane usher protein 566546004877 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 566546004878 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 566546004879 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 566546004880 Fimbrial protein; Region: Fimbrial; cl01416 566546004881 HipA N-terminal domain; Region: Couple_hipA; pfam13657 566546004882 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 566546004883 HipA-like N-terminal domain; Region: HipA_N; pfam07805 566546004884 HipA-like C-terminal domain; Region: HipA_C; pfam07804 566546004885 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 566546004886 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 566546004887 non-specific DNA binding site [nucleotide binding]; other site 566546004888 salt bridge; other site 566546004889 sequence-specific DNA binding site [nucleotide binding]; other site 566546004890 putative lipoprotein/autotransporter domain-containing protein; Provisional; Region: PRK14849 566546004891 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 566546004892 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 566546004893 Autotransporter beta-domain; Region: Autotransporter; pfam03797 566546004894 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 566546004895 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 566546004896 putative N- and C-terminal domain interface [polypeptide binding]; other site 566546004897 putative active site [active] 566546004898 putative MgATP binding site [chemical binding]; other site 566546004899 catalytic site [active] 566546004900 metal binding site [ion binding]; metal-binding site 566546004901 putative carbohydrate binding site [chemical binding]; other site 566546004902 transcriptional regulator LsrR; Provisional; Region: PRK15418 566546004903 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 566546004904 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 566546004905 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 566546004906 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 566546004907 Walker A/P-loop; other site 566546004908 ATP binding site [chemical binding]; other site 566546004909 Q-loop/lid; other site 566546004910 ABC transporter signature motif; other site 566546004911 Walker B; other site 566546004912 D-loop; other site 566546004913 H-loop/switch region; other site 566546004914 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 566546004915 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 566546004916 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 566546004917 TM-ABC transporter signature motif; other site 566546004918 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 566546004919 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 566546004920 TM-ABC transporter signature motif; other site 566546004921 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 566546004922 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 566546004923 ligand binding site [chemical binding]; other site 566546004924 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 566546004925 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 566546004926 putative active site; other site 566546004927 catalytic residue [active] 566546004928 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 566546004929 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 566546004930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546004931 S-adenosylmethionine binding site [chemical binding]; other site 566546004932 Predicted membrane protein [Function unknown]; Region: COG3781 566546004933 altronate oxidoreductase; Provisional; Region: PRK03643 566546004934 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 566546004935 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 566546004936 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 566546004937 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 566546004938 metal binding site [ion binding]; metal-binding site 566546004939 active site 566546004940 I-site; other site 566546004941 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 566546004942 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 566546004943 glutaminase; Provisional; Region: PRK00971 566546004944 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 566546004945 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 566546004946 NAD(P) binding site [chemical binding]; other site 566546004947 catalytic residues [active] 566546004948 Transcriptional regulator [Transcription]; Region: LysR; COG0583 566546004949 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546004950 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 566546004951 putative dimerization interface [polypeptide binding]; other site 566546004952 pseudogene, hypothetical protein 566546004953 putative arabinose transporter; Provisional; Region: PRK03545 566546004954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546004955 putative substrate translocation pore; other site 566546004956 inner membrane protein; Provisional; Region: PRK10995 566546004957 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 566546004958 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 566546004959 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 566546004960 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546004961 hypothetical protein; Provisional; Region: PRK10106 566546004962 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 566546004963 beta-galactosidase; Region: BGL; TIGR03356 566546004964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 566546004965 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 566546004966 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 566546004967 trimer interface; other site 566546004968 sugar binding site [chemical binding]; other site 566546004969 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 566546004970 active site 566546004971 methionine cluster; other site 566546004972 phosphorylation site [posttranslational modification] 566546004973 metal binding site [ion binding]; metal-binding site 566546004974 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 566546004975 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 566546004976 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 566546004977 active site 566546004978 P-loop; other site 566546004979 phosphorylation site [posttranslational modification] 566546004980 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 566546004981 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 566546004982 DNA-binding site [nucleotide binding]; DNA binding site 566546004983 UTRA domain; Region: UTRA; pfam07702 566546004984 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 566546004985 EamA-like transporter family; Region: EamA; pfam00892 566546004986 EamA-like transporter family; Region: EamA; pfam00892 566546004987 putative transporter; Provisional; Region: PRK10054 566546004988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546004989 putative substrate translocation pore; other site 566546004990 diguanylate cyclase; Provisional; Region: PRK09894 566546004991 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 566546004992 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 566546004993 metal binding site [ion binding]; metal-binding site 566546004994 active site 566546004995 I-site; other site 566546004996 hypothetical protein; Provisional; Region: PRK10053 566546004997 hypothetical protein; Validated; Region: PRK03657 566546004998 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 566546004999 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 566546005000 active site 566546005001 Zn binding site [ion binding]; other site 566546005002 malonic semialdehyde reductase; Provisional; Region: PRK10538 566546005003 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 566546005004 putative NAD(P) binding site [chemical binding]; other site 566546005005 homodimer interface [polypeptide binding]; other site 566546005006 homotetramer interface [polypeptide binding]; other site 566546005007 active site 566546005008 Transcriptional regulators [Transcription]; Region: GntR; COG1802 566546005009 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 566546005010 DNA-binding site [nucleotide binding]; DNA binding site 566546005011 FCD domain; Region: FCD; pfam07729 566546005012 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 566546005013 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 566546005014 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 566546005015 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 566546005016 pseudogene, Qin prophage 566546005017 multiple promoter invertase; Provisional; Region: mpi; PRK13413 566546005018 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 566546005019 catalytic residues [active] 566546005020 catalytic nucleophile [active] 566546005021 Presynaptic Site I dimer interface [polypeptide binding]; other site 566546005022 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 566546005023 Synaptic Flat tetramer interface [polypeptide binding]; other site 566546005024 Synaptic Site I dimer interface [polypeptide binding]; other site 566546005025 DNA binding site [nucleotide binding] 566546005026 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 566546005027 DNA-binding interface [nucleotide binding]; DNA binding site 566546005028 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 566546005029 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 566546005030 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 566546005031 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 566546005032 Phage Tail Collar Domain; Region: Collar; pfam07484 566546005033 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 566546005034 Phage-related protein, tail component [Function unknown]; Region: COG4733 566546005035 Putative phage tail protein; Region: Phage-tail_3; pfam13550 566546005036 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 566546005037 Interdomain contacts; other site 566546005038 Cytokine receptor motif; other site 566546005039 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 566546005040 Fibronectin type III protein; Region: DUF3672; pfam12421 566546005041 Phage-related protein, tail component [Function unknown]; Region: COG4723 566546005042 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 566546005043 MPN+ (JAMM) motif; other site 566546005044 Zinc-binding site [ion binding]; other site 566546005045 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 566546005046 NlpC/P60 family; Region: NLPC_P60; cl17555 566546005047 Phage-related protein [Function unknown]; Region: gp18; COG4672 566546005048 Phage-related protein [Function unknown]; Region: COG4718 566546005049 Phage-related minor tail protein [Function unknown]; Region: COG5281 566546005050 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 566546005051 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 566546005052 Minor tail protein T; Region: Phage_tail_T; pfam06223 566546005053 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 566546005054 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 566546005055 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 566546005056 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 566546005057 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 566546005058 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 566546005059 DNA packaging protein FI; Region: Packaging_FI; pfam14000 566546005060 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 566546005061 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 566546005062 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 566546005063 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 566546005064 tandem repeat interface [polypeptide binding]; other site 566546005065 oligomer interface [polypeptide binding]; other site 566546005066 active site residues [active] 566546005067 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 566546005068 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 566546005069 gpW; Region: gpW; pfam02831 566546005070 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 566546005071 pseudogene, DNA packing protein 566546005072 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 566546005073 GnsA/GnsB family; Region: GnsAB; pfam08178 566546005074 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 566546005075 DNA-binding site [nucleotide binding]; DNA binding site 566546005076 RNA-binding motif; other site 566546005077 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 566546005078 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 566546005079 catalytic residues [active] 566546005080 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 566546005081 Lysis protein S; Region: Lysis_S; pfam04971 566546005082 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 566546005083 DNA-binding site [nucleotide binding]; DNA binding site 566546005084 RNA-binding motif; other site 566546005085 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 566546005086 DNA-binding site [nucleotide binding]; DNA binding site 566546005087 RNA-binding motif; other site 566546005088 Antitermination protein; Region: Antiterm; pfam03589 566546005089 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 566546005090 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 566546005091 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 566546005092 Protein of unknown function (DUF968); Region: DUF968; pfam06147 566546005093 Hok/gef family; Region: HOK_GEF; pfam01848 566546005094 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 566546005095 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 566546005096 Homeodomain-like domain; Region: HTH_23; pfam13384 566546005097 Winged helix-turn helix; Region: HTH_29; pfam13551 566546005098 Homeodomain-like domain; Region: HTH_32; pfam13565 566546005099 Integrase core domain; Region: rve; pfam00665 566546005100 Integrase core domain; Region: rve_3; cl15866 566546005101 Methyltransferase domain; Region: Methyltransf_25; pfam13649 566546005102 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 566546005103 primosomal protein DnaI; Provisional; Region: PRK02854 566546005104 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 566546005105 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 566546005106 transcriptional repressor DicA; Reviewed; Region: PRK09706 566546005107 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 566546005108 non-specific DNA binding site [nucleotide binding]; other site 566546005109 salt bridge; other site 566546005110 sequence-specific DNA binding site [nucleotide binding]; other site 566546005111 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 566546005112 DicB protein; Region: DicB; pfam05358 566546005113 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 566546005114 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 566546005115 active site 566546005116 catalytic site [active] 566546005117 substrate binding site [chemical binding]; other site 566546005118 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 566546005119 pseudogene, integrase family protein 566546005120 putative oxidoreductase; Provisional; Region: PRK10083 566546005121 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 566546005122 putative NAD(P) binding site [chemical binding]; other site 566546005123 catalytic Zn binding site [ion binding]; other site 566546005124 structural Zn binding site [ion binding]; other site 566546005125 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 566546005126 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 566546005127 putative active site pocket [active] 566546005128 putative metal binding site [ion binding]; other site 566546005129 hypothetical protein; Provisional; Region: PRK02237 566546005130 hypothetical protein; Provisional; Region: PRK13659 566546005131 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 566546005132 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 566546005133 Coenzyme A binding pocket [chemical binding]; other site 566546005134 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 566546005135 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 566546005136 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 566546005137 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 566546005138 putative [Fe4-S4] binding site [ion binding]; other site 566546005139 putative molybdopterin cofactor binding site [chemical binding]; other site 566546005140 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 566546005141 putative molybdopterin cofactor binding site; other site 566546005142 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 566546005143 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 566546005144 putative [Fe4-S4] binding site [ion binding]; other site 566546005145 putative molybdopterin cofactor binding site [chemical binding]; other site 566546005146 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 566546005147 putative molybdopterin cofactor binding site; other site 566546005148 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 566546005149 4Fe-4S binding domain; Region: Fer4; cl02805 566546005150 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 566546005151 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 566546005152 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 566546005153 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 566546005154 Cl- selectivity filter; other site 566546005155 Cl- binding residues [ion binding]; other site 566546005156 pore gating glutamate residue; other site 566546005157 dimer interface [polypeptide binding]; other site 566546005158 putative dithiobiotin synthetase; Provisional; Region: PRK12374 566546005159 AAA domain; Region: AAA_26; pfam13500 566546005160 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 566546005161 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 566546005162 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 566546005163 nucleotide binding site [chemical binding]; other site 566546005164 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 566546005165 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546005166 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 566546005167 dimerization interface [polypeptide binding]; other site 566546005168 substrate binding pocket [chemical binding]; other site 566546005169 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 566546005170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546005171 putative substrate translocation pore; other site 566546005172 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 566546005173 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 566546005174 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 566546005175 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 566546005176 Domain of unknown function DUF20; Region: UPF0118; pfam01594 566546005177 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 566546005178 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 566546005179 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 566546005180 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 566546005181 ligand binding site [chemical binding]; other site 566546005182 homodimer interface [polypeptide binding]; other site 566546005183 NAD(P) binding site [chemical binding]; other site 566546005184 trimer interface B [polypeptide binding]; other site 566546005185 trimer interface A [polypeptide binding]; other site 566546005186 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 566546005187 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 566546005188 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 566546005189 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 566546005190 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 566546005191 Spore germination protein; Region: Spore_permease; cl17796 566546005192 dihydromonapterin reductase; Provisional; Region: PRK06483 566546005193 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 566546005194 NADP binding site [chemical binding]; other site 566546005195 substrate binding pocket [chemical binding]; other site 566546005196 active site 566546005197 GlpM protein; Region: GlpM; pfam06942 566546005198 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 566546005199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546005200 active site 566546005201 phosphorylation site [posttranslational modification] 566546005202 intermolecular recognition site; other site 566546005203 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 566546005204 DNA binding site [nucleotide binding] 566546005205 sensor protein RstB; Provisional; Region: PRK10604 566546005206 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 566546005207 dimerization interface [polypeptide binding]; other site 566546005208 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 566546005209 dimer interface [polypeptide binding]; other site 566546005210 phosphorylation site [posttranslational modification] 566546005211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546005212 ATP binding site [chemical binding]; other site 566546005213 Mg2+ binding site [ion binding]; other site 566546005214 G-X-G motif; other site 566546005215 pseudogene, truncated inhibitor of replication at Ter, DNA-binding protein 566546005216 fumarate hydratase; Reviewed; Region: fumC; PRK00485 566546005217 Class II fumarases; Region: Fumarase_classII; cd01362 566546005218 active site 566546005219 tetramer interface [polypeptide binding]; other site 566546005220 fumarate hydratase; Provisional; Region: PRK15389 566546005221 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 566546005222 Fumarase C-terminus; Region: Fumerase_C; pfam05683 566546005223 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 566546005224 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 566546005225 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 566546005226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 566546005227 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 566546005228 putative outer membrane porin protein; Provisional; Region: PRK11379 566546005229 glucuronide transporter; Provisional; Region: PRK09848 566546005230 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 566546005231 beta-D-glucuronidase; Provisional; Region: PRK10150 566546005232 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 566546005233 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 566546005234 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 566546005235 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 566546005236 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 566546005237 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 566546005238 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 566546005239 NAD binding site [chemical binding]; other site 566546005240 substrate binding site [chemical binding]; other site 566546005241 homotetramer interface [polypeptide binding]; other site 566546005242 homodimer interface [polypeptide binding]; other site 566546005243 active site 566546005244 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 566546005245 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 566546005246 DNA binding site [nucleotide binding] 566546005247 domain linker motif; other site 566546005248 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 566546005249 putative dimerization interface [polypeptide binding]; other site 566546005250 putative ligand binding site [chemical binding]; other site 566546005251 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 566546005252 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 566546005253 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 566546005254 active site turn [active] 566546005255 phosphorylation site [posttranslational modification] 566546005256 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 566546005257 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 566546005258 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546005259 homodimer interface [polypeptide binding]; other site 566546005260 catalytic residue [active] 566546005261 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 566546005262 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 566546005263 active site 566546005264 purine riboside binding site [chemical binding]; other site 566546005265 putative oxidoreductase; Provisional; Region: PRK11579 566546005266 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 566546005267 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 566546005268 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 566546005269 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 566546005270 electron transport complex protein RsxA; Provisional; Region: PRK05151 566546005271 electron transport complex protein RnfB; Provisional; Region: PRK05113 566546005272 Putative Fe-S cluster; Region: FeS; pfam04060 566546005273 4Fe-4S binding domain; Region: Fer4; pfam00037 566546005274 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 566546005275 SLBB domain; Region: SLBB; pfam10531 566546005276 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 566546005277 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 566546005278 electron transport complex protein RnfG; Validated; Region: PRK01908 566546005279 electron transport complex RsxE subunit; Provisional; Region: PRK12405 566546005280 endonuclease III; Provisional; Region: PRK10702 566546005281 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 566546005282 minor groove reading motif; other site 566546005283 helix-hairpin-helix signature motif; other site 566546005284 substrate binding pocket [chemical binding]; other site 566546005285 active site 566546005286 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 566546005287 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 566546005288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546005289 putative substrate translocation pore; other site 566546005290 POT family; Region: PTR2; pfam00854 566546005291 glutathionine S-transferase; Provisional; Region: PRK10542 566546005292 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 566546005293 C-terminal domain interface [polypeptide binding]; other site 566546005294 GSH binding site (G-site) [chemical binding]; other site 566546005295 dimer interface [polypeptide binding]; other site 566546005296 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 566546005297 N-terminal domain interface [polypeptide binding]; other site 566546005298 dimer interface [polypeptide binding]; other site 566546005299 substrate binding pocket (H-site) [chemical binding]; other site 566546005300 pyridoxamine kinase; Validated; Region: PRK05756 566546005301 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 566546005302 dimer interface [polypeptide binding]; other site 566546005303 pyridoxal binding site [chemical binding]; other site 566546005304 ATP binding site [chemical binding]; other site 566546005305 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 566546005306 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 566546005307 active site 566546005308 HIGH motif; other site 566546005309 dimer interface [polypeptide binding]; other site 566546005310 KMSKS motif; other site 566546005311 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 566546005312 RNA binding surface [nucleotide binding]; other site 566546005313 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 566546005314 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 566546005315 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 566546005316 lysozyme inhibitor; Provisional; Region: PRK11372 566546005317 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 566546005318 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 566546005319 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 566546005320 transcriptional regulator SlyA; Provisional; Region: PRK03573 566546005321 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 566546005322 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 566546005323 HlyD family secretion protein; Region: HlyD; pfam00529 566546005324 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 566546005325 HlyD family secretion protein; Region: HlyD_3; pfam13437 566546005326 Fusaric acid resistance protein family; Region: FUSC; pfam04632 566546005327 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 566546005328 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 566546005329 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 566546005330 E-class dimer interface [polypeptide binding]; other site 566546005331 P-class dimer interface [polypeptide binding]; other site 566546005332 active site 566546005333 Cu2+ binding site [ion binding]; other site 566546005334 Zn2+ binding site [ion binding]; other site 566546005335 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 566546005336 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 566546005337 active site 566546005338 catalytic tetrad [active] 566546005339 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 566546005340 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 566546005341 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 566546005342 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 566546005343 FMN binding site [chemical binding]; other site 566546005344 active site 566546005345 substrate binding site [chemical binding]; other site 566546005346 catalytic residue [active] 566546005347 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 566546005348 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 566546005349 dimer interface [polypeptide binding]; other site 566546005350 active site 566546005351 metal binding site [ion binding]; metal-binding site 566546005352 glutathione binding site [chemical binding]; other site 566546005353 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 566546005354 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 566546005355 dimer interface [polypeptide binding]; other site 566546005356 catalytic site [active] 566546005357 putative active site [active] 566546005358 putative substrate binding site [chemical binding]; other site 566546005359 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 566546005360 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 566546005361 ATP binding site [chemical binding]; other site 566546005362 putative Mg++ binding site [ion binding]; other site 566546005363 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 566546005364 nucleotide binding region [chemical binding]; other site 566546005365 ATP-binding site [chemical binding]; other site 566546005366 DEAD/H associated; Region: DEAD_assoc; pfam08494 566546005367 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 566546005368 putative GSH binding site [chemical binding]; other site 566546005369 catalytic residues [active] 566546005370 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 566546005371 NlpC/P60 family; Region: NLPC_P60; pfam00877 566546005372 superoxide dismutase; Provisional; Region: PRK10543 566546005373 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 566546005374 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 566546005375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546005376 Major Facilitator Superfamily; Region: MFS_1; pfam07690 566546005377 putative substrate translocation pore; other site 566546005378 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 566546005379 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 566546005380 DNA binding site [nucleotide binding] 566546005381 domain linker motif; other site 566546005382 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 566546005383 dimerization interface [polypeptide binding]; other site 566546005384 ligand binding site [chemical binding]; other site 566546005385 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 566546005386 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546005387 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 566546005388 dimerization interface [polypeptide binding]; other site 566546005389 putative transporter; Provisional; Region: PRK11043 566546005390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546005391 putative substrate translocation pore; other site 566546005392 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 566546005393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 566546005394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546005395 S-adenosylmethionine binding site [chemical binding]; other site 566546005396 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 566546005397 Lumazine binding domain; Region: Lum_binding; pfam00677 566546005398 Lumazine binding domain; Region: Lum_binding; pfam00677 566546005399 multidrug efflux protein; Reviewed; Region: PRK01766 566546005400 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 566546005401 cation binding site [ion binding]; other site 566546005402 hypothetical protein; Provisional; Region: PRK09945 566546005403 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 566546005404 putative monooxygenase; Provisional; Region: PRK11118 566546005405 hypothetical protein; Provisional; Region: PRK09897 566546005406 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 566546005407 hypothetical protein; Provisional; Region: PRK09946 566546005408 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 566546005409 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 566546005410 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 566546005411 hypothetical protein; Provisional; Region: PRK09947 566546005412 putative oxidoreductase; Provisional; Region: PRK09849 566546005413 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 566546005414 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 566546005415 hypothetical protein; Provisional; Region: PRK09898 566546005416 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 566546005417 hypothetical protein; Provisional; Region: PRK10292 566546005418 pyruvate kinase; Provisional; Region: PRK09206 566546005419 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 566546005420 domain interfaces; other site 566546005421 active site 566546005422 murein lipoprotein; Provisional; Region: PRK15396 566546005423 L,D-transpeptidase; Provisional; Region: PRK10190 566546005424 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 566546005425 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 566546005426 cysteine desufuration protein SufE; Provisional; Region: PRK09296 566546005427 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 566546005428 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 566546005429 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 566546005430 catalytic residue [active] 566546005431 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 566546005432 FeS assembly protein SufD; Region: sufD; TIGR01981 566546005433 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 566546005434 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 566546005435 Walker A/P-loop; other site 566546005436 ATP binding site [chemical binding]; other site 566546005437 Q-loop/lid; other site 566546005438 ABC transporter signature motif; other site 566546005439 Walker B; other site 566546005440 D-loop; other site 566546005441 H-loop/switch region; other site 566546005442 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 566546005443 putative ABC transporter; Region: ycf24; CHL00085 566546005444 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 566546005445 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 566546005446 CoenzymeA binding site [chemical binding]; other site 566546005447 subunit interaction site [polypeptide binding]; other site 566546005448 PHB binding site; other site 566546005449 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 566546005450 FAD binding domain; Region: FAD_binding_4; pfam01565 566546005451 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 566546005452 putative inner membrane protein; Provisional; Region: PRK10983 566546005453 Domain of unknown function DUF20; Region: UPF0118; pfam01594 566546005454 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 566546005455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546005456 Major Facilitator Superfamily; Region: MFS_1; pfam07690 566546005457 putative substrate translocation pore; other site 566546005458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546005459 putative substrate translocation pore; other site 566546005460 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 566546005461 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 566546005462 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 566546005463 shikimate binding site; other site 566546005464 NAD(P) binding site [chemical binding]; other site 566546005465 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 566546005466 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 566546005467 active site 566546005468 catalytic residue [active] 566546005469 dimer interface [polypeptide binding]; other site 566546005470 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 566546005471 Coenzyme A transferase; Region: CoA_trans; smart00882 566546005472 Coenzyme A transferase; Region: CoA_trans; cl17247 566546005473 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 566546005474 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 566546005475 active site 566546005476 Cupin domain; Region: Cupin_2; pfam07883 566546005477 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 566546005478 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 566546005479 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546005480 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 566546005481 Ligand binding site [chemical binding]; other site 566546005482 Electron transfer flavoprotein domain; Region: ETF; pfam01012 566546005483 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 566546005484 Electron transfer flavoprotein domain; Region: ETF; smart00893 566546005485 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 566546005486 oxidoreductase; Provisional; Region: PRK10015 566546005487 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 566546005488 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 566546005489 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 566546005490 acyl-activating enzyme (AAE) consensus motif; other site 566546005491 putative AMP binding site [chemical binding]; other site 566546005492 putative active site [active] 566546005493 putative CoA binding site [chemical binding]; other site 566546005494 phosphoenolpyruvate synthase; Validated; Region: PRK06464 566546005495 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 566546005496 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 566546005497 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 566546005498 PEP synthetase regulatory protein; Provisional; Region: PRK05339 566546005499 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 566546005500 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 566546005501 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 566546005502 Uncharacterized conserved protein [Function unknown]; Region: COG0397 566546005503 hypothetical protein; Validated; Region: PRK00029 566546005504 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 566546005505 NlpC/P60 family; Region: NLPC_P60; pfam00877 566546005506 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 566546005507 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 566546005508 Walker A/P-loop; other site 566546005509 ATP binding site [chemical binding]; other site 566546005510 Q-loop/lid; other site 566546005511 ABC transporter signature motif; other site 566546005512 Walker B; other site 566546005513 D-loop; other site 566546005514 H-loop/switch region; other site 566546005515 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 566546005516 catalytic residues [active] 566546005517 dimer interface [polypeptide binding]; other site 566546005518 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 566546005519 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 566546005520 ABC-ATPase subunit interface; other site 566546005521 dimer interface [polypeptide binding]; other site 566546005522 putative PBP binding regions; other site 566546005523 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 566546005524 IHF dimer interface [polypeptide binding]; other site 566546005525 IHF - DNA interface [nucleotide binding]; other site 566546005526 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 566546005527 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 566546005528 putative tRNA-binding site [nucleotide binding]; other site 566546005529 B3/4 domain; Region: B3_4; pfam03483 566546005530 tRNA synthetase B5 domain; Region: B5; smart00874 566546005531 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 566546005532 dimer interface [polypeptide binding]; other site 566546005533 motif 1; other site 566546005534 motif 3; other site 566546005535 motif 2; other site 566546005536 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 566546005537 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 566546005538 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 566546005539 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 566546005540 dimer interface [polypeptide binding]; other site 566546005541 motif 1; other site 566546005542 active site 566546005543 motif 2; other site 566546005544 motif 3; other site 566546005545 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 566546005546 23S rRNA binding site [nucleotide binding]; other site 566546005547 L21 binding site [polypeptide binding]; other site 566546005548 L13 binding site [polypeptide binding]; other site 566546005549 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 566546005550 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 566546005551 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 566546005552 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 566546005553 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 566546005554 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 566546005555 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 566546005556 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 566546005557 active site 566546005558 dimer interface [polypeptide binding]; other site 566546005559 motif 1; other site 566546005560 motif 2; other site 566546005561 motif 3; other site 566546005562 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 566546005563 anticodon binding site; other site 566546005564 pseudogene, hypothetical protein 566546005565 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 566546005566 6-phosphofructokinase 2; Provisional; Region: PRK10294 566546005567 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 566546005568 putative substrate binding site [chemical binding]; other site 566546005569 putative ATP binding site [chemical binding]; other site 566546005570 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 566546005571 Phosphotransferase enzyme family; Region: APH; pfam01636 566546005572 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 566546005573 active site 566546005574 ATP binding site [chemical binding]; other site 566546005575 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 566546005576 YniB-like protein; Region: YniB; pfam14002 566546005577 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 566546005578 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 566546005579 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 566546005580 motif II; other site 566546005581 inner membrane protein; Provisional; Region: PRK11648 566546005582 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 566546005583 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 566546005584 pseudogene, conserved hypothetical protein 566546005585 cell division modulator; Provisional; Region: PRK10113 566546005586 hydroperoxidase II; Provisional; Region: katE; PRK11249 566546005587 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 566546005588 tetramer interface [polypeptide binding]; other site 566546005589 heme binding pocket [chemical binding]; other site 566546005590 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 566546005591 domain interactions; other site 566546005592 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 566546005593 putative active site [active] 566546005594 YdjC motif; other site 566546005595 Mg binding site [ion binding]; other site 566546005596 putative homodimer interface [polypeptide binding]; other site 566546005597 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 566546005598 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 566546005599 NAD binding site [chemical binding]; other site 566546005600 sugar binding site [chemical binding]; other site 566546005601 divalent metal binding site [ion binding]; other site 566546005602 tetramer (dimer of dimers) interface [polypeptide binding]; other site 566546005603 dimer interface [polypeptide binding]; other site 566546005604 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 566546005605 Cupin domain; Region: Cupin_2; pfam07883 566546005606 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546005607 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 566546005608 methionine cluster; other site 566546005609 active site 566546005610 phosphorylation site [posttranslational modification] 566546005611 metal binding site [ion binding]; metal-binding site 566546005612 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 566546005613 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 566546005614 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 566546005615 active site 566546005616 P-loop; other site 566546005617 phosphorylation site [posttranslational modification] 566546005618 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 566546005619 NAD+ synthetase; Region: nadE; TIGR00552 566546005620 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 566546005621 homodimer interface [polypeptide binding]; other site 566546005622 NAD binding pocket [chemical binding]; other site 566546005623 ATP binding pocket [chemical binding]; other site 566546005624 Mg binding site [ion binding]; other site 566546005625 active-site loop [active] 566546005626 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 566546005627 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 566546005628 GIY-YIG motif/motif A; other site 566546005629 active site 566546005630 catalytic site [active] 566546005631 putative DNA binding site [nucleotide binding]; other site 566546005632 metal binding site [ion binding]; metal-binding site 566546005633 hypothetical protein; Provisional; Region: PRK11396 566546005634 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 566546005635 dimer interface [polypeptide binding]; other site 566546005636 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 566546005637 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 566546005638 putative active site [active] 566546005639 Zn binding site [ion binding]; other site 566546005640 succinylarginine dihydrolase; Provisional; Region: PRK13281 566546005641 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 566546005642 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 566546005643 NAD(P) binding site [chemical binding]; other site 566546005644 catalytic residues [active] 566546005645 arginine succinyltransferase; Provisional; Region: PRK10456 566546005646 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 566546005647 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 566546005648 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 566546005649 inhibitor-cofactor binding pocket; inhibition site 566546005650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546005651 catalytic residue [active] 566546005652 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 566546005653 putative catalytic site [active] 566546005654 putative phosphate binding site [ion binding]; other site 566546005655 active site 566546005656 metal binding site A [ion binding]; metal-binding site 566546005657 DNA binding site [nucleotide binding] 566546005658 putative AP binding site [nucleotide binding]; other site 566546005659 putative metal binding site B [ion binding]; other site 566546005660 Uncharacterized conserved protein [Function unknown]; Region: COG0398 566546005661 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 566546005662 Uncharacterized conserved protein [Function unknown]; Region: COG0398 566546005663 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 566546005664 Uncharacterized conserved protein [Function unknown]; Region: COG2128 566546005665 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 566546005666 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 566546005667 hypothetical protein; Provisional; Region: PRK11622 566546005668 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 566546005669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546005670 dimer interface [polypeptide binding]; other site 566546005671 conserved gate region; other site 566546005672 putative PBP binding loops; other site 566546005673 ABC-ATPase subunit interface; other site 566546005674 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 566546005675 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 566546005676 Walker A/P-loop; other site 566546005677 ATP binding site [chemical binding]; other site 566546005678 Q-loop/lid; other site 566546005679 ABC transporter signature motif; other site 566546005680 Walker B; other site 566546005681 D-loop; other site 566546005682 H-loop/switch region; other site 566546005683 Rhodanese Homology Domain; Region: RHOD; smart00450 566546005684 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 566546005685 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 566546005686 active site residue [active] 566546005687 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 566546005688 active site residue [active] 566546005689 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 566546005690 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 566546005691 active site 566546005692 8-oxo-dGMP binding site [chemical binding]; other site 566546005693 nudix motif; other site 566546005694 metal binding site [ion binding]; metal-binding site 566546005695 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 566546005696 glutamate dehydrogenase; Provisional; Region: PRK09414 566546005697 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 566546005698 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 566546005699 NAD(P) binding site [chemical binding]; other site 566546005700 hypothetical protein; Provisional; Region: PRK11380 566546005701 DNA topoisomerase III; Provisional; Region: PRK07726 566546005702 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 566546005703 active site 566546005704 putative interdomain interaction site [polypeptide binding]; other site 566546005705 putative metal-binding site [ion binding]; other site 566546005706 putative nucleotide binding site [chemical binding]; other site 566546005707 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 566546005708 domain I; other site 566546005709 DNA binding groove [nucleotide binding] 566546005710 phosphate binding site [ion binding]; other site 566546005711 domain II; other site 566546005712 domain III; other site 566546005713 nucleotide binding site [chemical binding]; other site 566546005714 catalytic site [active] 566546005715 domain IV; other site 566546005716 selenophosphate synthetase; Provisional; Region: PRK00943 566546005717 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 566546005718 dimerization interface [polypeptide binding]; other site 566546005719 putative ATP binding site [chemical binding]; other site 566546005720 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 566546005721 putative FMN binding site [chemical binding]; other site 566546005722 protease 4; Provisional; Region: PRK10949 566546005723 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 566546005724 tandem repeat interface [polypeptide binding]; other site 566546005725 oligomer interface [polypeptide binding]; other site 566546005726 active site residues [active] 566546005727 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 566546005728 tandem repeat interface [polypeptide binding]; other site 566546005729 oligomer interface [polypeptide binding]; other site 566546005730 active site residues [active] 566546005731 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 566546005732 homodimer interface [polypeptide binding]; other site 566546005733 active site 566546005734 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 566546005735 Isochorismatase family; Region: Isochorismatase; pfam00857 566546005736 catalytic triad [active] 566546005737 metal binding site [ion binding]; metal-binding site 566546005738 conserved cis-peptide bond; other site 566546005739 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 566546005740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546005741 putative substrate translocation pore; other site 566546005742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546005743 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 566546005744 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 566546005745 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 566546005746 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 566546005747 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 566546005748 active site 566546005749 catalytic tetrad [active] 566546005750 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 566546005751 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 566546005752 substrate binding site [chemical binding]; other site 566546005753 ATP binding site [chemical binding]; other site 566546005754 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 566546005755 intersubunit interface [polypeptide binding]; other site 566546005756 active site 566546005757 zinc binding site [ion binding]; other site 566546005758 Na+ binding site [ion binding]; other site 566546005759 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 566546005760 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 566546005761 inhibitor binding site; inhibition site 566546005762 catalytic Zn binding site [ion binding]; other site 566546005763 structural Zn binding site [ion binding]; other site 566546005764 NADP binding site [chemical binding]; other site 566546005765 tetramer interface [polypeptide binding]; other site 566546005766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546005767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546005768 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 566546005769 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 566546005770 putative NAD(P) binding site [chemical binding]; other site 566546005771 catalytic Zn binding site [ion binding]; other site 566546005772 structural Zn binding site [ion binding]; other site 566546005773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 566546005774 methionine sulfoxide reductase B; Provisional; Region: PRK00222 566546005775 SelR domain; Region: SelR; pfam01641 566546005776 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 566546005777 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 566546005778 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 566546005779 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 566546005780 active site 566546005781 phosphate binding residues; other site 566546005782 catalytic residues [active] 566546005783 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 566546005784 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 566546005785 active site 566546005786 catalytic tetrad [active] 566546005787 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 566546005788 PrkA family serine protein kinase; Provisional; Region: PRK15455 566546005789 AAA ATPase domain; Region: AAA_16; pfam13191 566546005790 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 566546005791 hypothetical protein; Provisional; Region: PRK05325 566546005792 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 566546005793 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 566546005794 metal binding site [ion binding]; metal-binding site 566546005795 active site 566546005796 I-site; other site 566546005797 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 566546005798 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 566546005799 metal binding site [ion binding]; metal-binding site 566546005800 active site 566546005801 I-site; other site 566546005802 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 566546005803 putative deacylase active site [active] 566546005804 Predicted membrane protein [Function unknown]; Region: COG2707 566546005805 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 566546005806 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546005807 cyanate transporter; Region: CynX; TIGR00896 566546005808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546005809 putative substrate translocation pore; other site 566546005810 Uncharacterized conserved protein [Function unknown]; Region: COG3189 566546005811 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 566546005812 Domain of unknown function (DUF333); Region: DUF333; pfam03891 566546005813 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 566546005814 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 566546005815 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 566546005816 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 566546005817 metal binding site [ion binding]; metal-binding site 566546005818 active site 566546005819 I-site; other site 566546005820 hypothetical protein; Provisional; Region: PRK10457 566546005821 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 566546005822 Probable transposase; Region: OrfB_IS605; pfam01385 566546005823 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 566546005824 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 566546005825 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 566546005826 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 566546005827 leucine export protein LeuE; Provisional; Region: PRK10958 566546005828 transcriptional activator TtdR; Provisional; Region: PRK09801 566546005829 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546005830 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 566546005831 putative effector binding pocket; other site 566546005832 putative dimerization interface [polypeptide binding]; other site 566546005833 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 566546005834 tartrate dehydrogenase; Region: TTC; TIGR02089 566546005835 putative transporter; Provisional; Region: PRK09950 566546005836 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 566546005837 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 566546005838 [2Fe-2S] cluster binding site [ion binding]; other site 566546005839 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 566546005840 putative alpha subunit interface [polypeptide binding]; other site 566546005841 putative active site [active] 566546005842 putative substrate binding site [chemical binding]; other site 566546005843 Fe binding site [ion binding]; other site 566546005844 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 566546005845 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 566546005846 FMN-binding pocket [chemical binding]; other site 566546005847 flavin binding motif; other site 566546005848 phosphate binding motif [ion binding]; other site 566546005849 beta-alpha-beta structure motif; other site 566546005850 NAD binding pocket [chemical binding]; other site 566546005851 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 566546005852 catalytic loop [active] 566546005853 iron binding site [ion binding]; other site 566546005854 ribonuclease D; Provisional; Region: PRK10829 566546005855 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 566546005856 catalytic site [active] 566546005857 putative active site [active] 566546005858 putative substrate binding site [chemical binding]; other site 566546005859 Helicase and RNase D C-terminal; Region: HRDC; smart00341 566546005860 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 566546005861 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 566546005862 acyl-activating enzyme (AAE) consensus motif; other site 566546005863 putative AMP binding site [chemical binding]; other site 566546005864 putative active site [active] 566546005865 putative CoA binding site [chemical binding]; other site 566546005866 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 566546005867 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 566546005868 Glycoprotease family; Region: Peptidase_M22; pfam00814 566546005869 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 566546005870 DEAD/DEAH box helicase; Region: DEAD; pfam00270 566546005871 DEAD_2; Region: DEAD_2; pfam06733 566546005872 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 566546005873 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 566546005874 homotrimer interaction site [polypeptide binding]; other site 566546005875 putative active site [active] 566546005876 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 566546005877 hypothetical protein; Provisional; Region: PRK05114 566546005878 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 566546005879 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 566546005880 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 566546005881 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 566546005882 putative active site [active] 566546005883 putative CoA binding site [chemical binding]; other site 566546005884 nudix motif; other site 566546005885 metal binding site [ion binding]; metal-binding site 566546005886 L-serine deaminase; Provisional; Region: PRK15023 566546005887 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 566546005888 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 566546005889 phage resistance protein; Provisional; Region: PRK10551 566546005890 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 566546005891 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 566546005892 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 566546005893 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 566546005894 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 566546005895 Transporter associated domain; Region: CorC_HlyC; smart01091 566546005896 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 566546005897 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 566546005898 active pocket/dimerization site; other site 566546005899 active site 566546005900 phosphorylation site [posttranslational modification] 566546005901 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 566546005902 active site 566546005903 phosphorylation site [posttranslational modification] 566546005904 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 566546005905 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 566546005906 Predicted membrane protein [Function unknown]; Region: COG4811 566546005907 hypothetical protein; Provisional; Region: PRK11469 566546005908 Domain of unknown function DUF; Region: DUF204; pfam02659 566546005909 Domain of unknown function DUF; Region: DUF204; pfam02659 566546005910 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 566546005911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546005912 S-adenosylmethionine binding site [chemical binding]; other site 566546005913 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 566546005914 DNA-binding site [nucleotide binding]; DNA binding site 566546005915 RNA-binding motif; other site 566546005916 YebO-like protein; Region: YebO; pfam13974 566546005917 PhoPQ regulatory protein; Provisional; Region: PRK10299 566546005918 YobH-like protein; Region: YobH; pfam13996 566546005919 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 566546005920 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 566546005921 dimerization interface [polypeptide binding]; other site 566546005922 putative Zn2+ binding site [ion binding]; other site 566546005923 putative DNA binding site [nucleotide binding]; other site 566546005924 Bacterial transcriptional regulator; Region: IclR; pfam01614 566546005925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546005926 Major Facilitator Superfamily; Region: MFS_1; pfam07690 566546005927 putative substrate translocation pore; other site 566546005928 Predicted integral membrane protein [Function unknown]; Region: COG5521 566546005929 heat shock protein HtpX; Provisional; Region: PRK05457 566546005930 carboxy-terminal protease; Provisional; Region: PRK11186 566546005931 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 566546005932 protein binding site [polypeptide binding]; other site 566546005933 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 566546005934 Catalytic dyad [active] 566546005935 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 566546005936 ProP expression regulator; Provisional; Region: PRK04950 566546005937 ProQ/FINO family; Region: ProQ; pfam04352 566546005938 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 566546005939 GAF domain; Region: GAF_2; pfam13185 566546005940 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 566546005941 Paraquat-inducible protein A; Region: PqiA; pfam04403 566546005942 Paraquat-inducible protein A; Region: PqiA; pfam04403 566546005943 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 566546005944 mce related protein; Region: MCE; pfam02470 566546005945 mce related protein; Region: MCE; pfam02470 566546005946 mce related protein; Region: MCE; pfam02470 566546005947 mce related protein; Region: MCE; pfam02470 566546005948 mce related protein; Region: MCE; pfam02470 566546005949 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 566546005950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546005951 S-adenosylmethionine binding site [chemical binding]; other site 566546005952 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 566546005953 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 566546005954 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 566546005955 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 566546005956 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 566546005957 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 566546005958 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 566546005959 hypothetical protein; Provisional; Region: PRK10301 566546005960 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 566546005961 Predicted amidohydrolase [General function prediction only]; Region: COG0388 566546005962 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 566546005963 exodeoxyribonuclease X; Provisional; Region: PRK07983 566546005964 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 566546005965 active site 566546005966 catalytic site [active] 566546005967 substrate binding site [chemical binding]; other site 566546005968 protease 2; Provisional; Region: PRK10115 566546005969 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 566546005970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 566546005971 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 566546005972 putative metal binding site [ion binding]; other site 566546005973 hypothetical protein; Provisional; Region: PRK13680 566546005974 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 566546005975 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 566546005976 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 566546005977 ATP-grasp domain; Region: ATP-grasp; pfam02222 566546005978 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 566546005979 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 566546005980 active site 566546005981 intersubunit interface [polypeptide binding]; other site 566546005982 catalytic residue [active] 566546005983 phosphogluconate dehydratase; Validated; Region: PRK09054 566546005984 6-phosphogluconate dehydratase; Region: edd; TIGR01196 566546005985 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 566546005986 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 566546005987 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 566546005988 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 566546005989 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 566546005990 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 566546005991 putative active site [active] 566546005992 pyruvate kinase; Provisional; Region: PRK05826 566546005993 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 566546005994 domain interfaces; other site 566546005995 active site 566546005996 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 566546005997 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 566546005998 putative acyl-acceptor binding pocket; other site 566546005999 putative peptidase; Provisional; Region: PRK11649 566546006000 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 566546006001 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 566546006002 Peptidase family M23; Region: Peptidase_M23; pfam01551 566546006003 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 566546006004 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 566546006005 metal binding site [ion binding]; metal-binding site 566546006006 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 566546006007 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 566546006008 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 566546006009 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 566546006010 ABC-ATPase subunit interface; other site 566546006011 dimer interface [polypeptide binding]; other site 566546006012 putative PBP binding regions; other site 566546006013 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 566546006014 Transposase; Region: DEDD_Tnp_IS110; pfam01548 566546006015 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 566546006016 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 566546006017 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546006018 Walker A motif; other site 566546006019 ATP binding site [chemical binding]; other site 566546006020 Walker B motif; other site 566546006021 arginine finger; other site 566546006022 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 566546006023 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 566546006024 RuvA N terminal domain; Region: RuvA_N; pfam01330 566546006025 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 566546006026 hypothetical protein; Provisional; Region: PRK11470 566546006027 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 566546006028 active site 566546006029 putative DNA-binding cleft [nucleotide binding]; other site 566546006030 dimer interface [polypeptide binding]; other site 566546006031 hypothetical protein; Validated; Region: PRK00110 566546006032 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 566546006033 nudix motif; other site 566546006034 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 566546006035 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 566546006036 dimer interface [polypeptide binding]; other site 566546006037 anticodon binding site; other site 566546006038 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 566546006039 homodimer interface [polypeptide binding]; other site 566546006040 motif 1; other site 566546006041 active site 566546006042 motif 2; other site 566546006043 GAD domain; Region: GAD; pfam02938 566546006044 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 566546006045 motif 3; other site 566546006046 Isochorismatase family; Region: Isochorismatase; pfam00857 566546006047 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 566546006048 catalytic triad [active] 566546006049 conserved cis-peptide bond; other site 566546006050 hypothetical protein; Provisional; Region: PRK10302 566546006051 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 566546006052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546006053 S-adenosylmethionine binding site [chemical binding]; other site 566546006054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546006055 S-adenosylmethionine binding site [chemical binding]; other site 566546006056 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 566546006057 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 566546006058 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 566546006059 molybdopterin cofactor binding site [chemical binding]; other site 566546006060 substrate binding site [chemical binding]; other site 566546006061 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 566546006062 molybdopterin cofactor binding site; other site 566546006063 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 566546006064 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 566546006065 copper homeostasis protein CutC; Provisional; Region: PRK11572 566546006066 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 566546006067 putative metal binding site [ion binding]; other site 566546006068 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 566546006069 arginyl-tRNA synthetase; Region: argS; TIGR00456 566546006070 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 566546006071 active site 566546006072 HIGH motif; other site 566546006073 KMSK motif region; other site 566546006074 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 566546006075 tRNA binding surface [nucleotide binding]; other site 566546006076 anticodon binding site; other site 566546006077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 566546006078 Flagellar protein FlhE; Region: FlhE; pfam06366 566546006079 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 566546006080 FHIPEP family; Region: FHIPEP; pfam00771 566546006081 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 566546006082 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 566546006083 chemotaxis regulator CheZ; Provisional; Region: PRK11166 566546006084 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 566546006085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546006086 active site 566546006087 phosphorylation site [posttranslational modification] 566546006088 intermolecular recognition site; other site 566546006089 dimerization interface [polypeptide binding]; other site 566546006090 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 566546006091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546006092 active site 566546006093 phosphorylation site [posttranslational modification] 566546006094 intermolecular recognition site; other site 566546006095 dimerization interface [polypeptide binding]; other site 566546006096 CheB methylesterase; Region: CheB_methylest; pfam01339 566546006097 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 566546006098 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 566546006099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546006100 S-adenosylmethionine binding site [chemical binding]; other site 566546006101 methyl-accepting protein IV; Provisional; Region: PRK09793 566546006102 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 566546006103 dimer interface [polypeptide binding]; other site 566546006104 ligand binding site [chemical binding]; other site 566546006105 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 566546006106 dimerization interface [polypeptide binding]; other site 566546006107 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 566546006108 dimer interface [polypeptide binding]; other site 566546006109 putative CheW interface [polypeptide binding]; other site 566546006110 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 566546006111 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 566546006112 dimer interface [polypeptide binding]; other site 566546006113 ligand binding site [chemical binding]; other site 566546006114 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 566546006115 dimerization interface [polypeptide binding]; other site 566546006116 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 566546006117 dimer interface [polypeptide binding]; other site 566546006118 putative CheW interface [polypeptide binding]; other site 566546006119 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 566546006120 putative CheA interaction surface; other site 566546006121 chemotaxis protein CheA; Provisional; Region: PRK10547 566546006122 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 566546006123 putative binding surface; other site 566546006124 active site 566546006125 CheY binding; Region: CheY-binding; pfam09078 566546006126 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 566546006127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546006128 ATP binding site [chemical binding]; other site 566546006129 Mg2+ binding site [ion binding]; other site 566546006130 G-X-G motif; other site 566546006131 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 566546006132 flagellar motor protein MotB; Validated; Region: motB; PRK09041 566546006133 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 566546006134 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 566546006135 ligand binding site [chemical binding]; other site 566546006136 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 566546006137 flagellar motor protein MotA; Validated; Region: PRK09110 566546006138 transcriptional activator FlhC; Provisional; Region: PRK12722 566546006139 transcriptional activator FlhD; Provisional; Region: PRK02909 566546006140 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 566546006141 Ligand Binding Site [chemical binding]; other site 566546006142 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 566546006143 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 566546006144 active site 566546006145 homotetramer interface [polypeptide binding]; other site 566546006146 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 566546006147 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 566546006148 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 566546006149 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 566546006150 TM-ABC transporter signature motif; other site 566546006151 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 566546006152 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 566546006153 Walker A/P-loop; other site 566546006154 ATP binding site [chemical binding]; other site 566546006155 Q-loop/lid; other site 566546006156 ABC transporter signature motif; other site 566546006157 Walker B; other site 566546006158 D-loop; other site 566546006159 H-loop/switch region; other site 566546006160 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 566546006161 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 566546006162 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 566546006163 ligand binding site [chemical binding]; other site 566546006164 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 566546006165 Ferritin-like domain; Region: Ferritin; pfam00210 566546006166 ferroxidase diiron center [ion binding]; other site 566546006167 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 566546006168 YecR-like lipoprotein; Region: YecR; pfam13992 566546006169 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 566546006170 Ferritin-like domain; Region: Ferritin; pfam00210 566546006171 ferroxidase diiron center [ion binding]; other site 566546006172 probable metal-binding protein; Region: matur_matur; TIGR03853 566546006173 tyrosine transporter TyrP; Provisional; Region: PRK15132 566546006174 aromatic amino acid transport protein; Region: araaP; TIGR00837 566546006175 hypothetical protein; Provisional; Region: PRK10396 566546006176 yecA family protein; Region: ygfB_yecA; TIGR02292 566546006177 SEC-C motif; Region: SEC-C; pfam02810 566546006178 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 566546006179 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 566546006180 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 566546006181 GIY-YIG motif/motif A; other site 566546006182 active site 566546006183 catalytic site [active] 566546006184 putative DNA binding site [nucleotide binding]; other site 566546006185 metal binding site [ion binding]; metal-binding site 566546006186 UvrB/uvrC motif; Region: UVR; pfam02151 566546006187 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 566546006188 Helix-hairpin-helix motif; Region: HHH; pfam00633 566546006189 response regulator; Provisional; Region: PRK09483 566546006190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546006191 active site 566546006192 phosphorylation site [posttranslational modification] 566546006193 intermolecular recognition site; other site 566546006194 dimerization interface [polypeptide binding]; other site 566546006195 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 566546006196 DNA binding residues [nucleotide binding] 566546006197 dimerization interface [polypeptide binding]; other site 566546006198 hypothetical protein; Provisional; Region: PRK10613 566546006199 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 566546006200 Autoinducer binding domain; Region: Autoind_bind; pfam03472 566546006201 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 566546006202 DNA binding residues [nucleotide binding] 566546006203 dimerization interface [polypeptide binding]; other site 566546006204 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 566546006205 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 566546006206 Walker A/P-loop; other site 566546006207 ATP binding site [chemical binding]; other site 566546006208 Q-loop/lid; other site 566546006209 ABC transporter signature motif; other site 566546006210 Walker B; other site 566546006211 D-loop; other site 566546006212 H-loop/switch region; other site 566546006213 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 566546006214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546006215 dimer interface [polypeptide binding]; other site 566546006216 conserved gate region; other site 566546006217 putative PBP binding loops; other site 566546006218 ABC-ATPase subunit interface; other site 566546006219 D-cysteine desulfhydrase; Validated; Region: PRK03910 566546006220 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 566546006221 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546006222 catalytic residue [active] 566546006223 cystine transporter subunit; Provisional; Region: PRK11260 566546006224 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 566546006225 substrate binding pocket [chemical binding]; other site 566546006226 membrane-bound complex binding site; other site 566546006227 hinge residues; other site 566546006228 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 566546006229 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 566546006230 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 566546006231 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 566546006232 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 566546006233 DNA binding residues [nucleotide binding] 566546006234 flagellin; Validated; Region: PRK08026 566546006235 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 566546006236 Flagellin protein; Region: FliC; pfam12445 566546006237 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 566546006238 flagellar capping protein; Reviewed; Region: fliD; PRK08032 566546006239 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 566546006240 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 566546006241 Flagellar protein FliS; Region: FliS; cl00654 566546006242 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 566546006243 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 566546006244 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 566546006245 active site 566546006246 Na/Ca binding site [ion binding]; other site 566546006247 catalytic site [active] 566546006248 lipoprotein; Provisional; Region: PRK10397 566546006249 putative inner membrane protein; Provisional; Region: PRK11099 566546006250 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 566546006251 CPxP motif; other site 566546006252 hypothetical protein; Provisional; Region: PRK09951 566546006253 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 566546006254 Probable transposase; Region: OrfB_IS605; pfam01385 566546006255 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 566546006256 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 566546006257 pseudogene, putative IS609 Transposase ORF2 566546006258 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 566546006259 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 566546006260 substrate binding site [chemical binding]; other site 566546006261 multidrug efflux protein; Reviewed; Region: emrE; PRK09541 566546006262 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 566546006263 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 566546006264 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 566546006265 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 566546006266 flagellar motor switch protein FliG; Region: fliG; TIGR00207 566546006267 FliG C-terminal domain; Region: FliG_C; pfam01706 566546006268 flagellar assembly protein H; Validated; Region: fliH; PRK05687 566546006269 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 566546006270 Flagellar assembly protein FliH; Region: FliH; pfam02108 566546006271 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 566546006272 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 566546006273 Walker A motif/ATP binding site; other site 566546006274 Walker B motif; other site 566546006275 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 566546006276 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 566546006277 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 566546006278 flagellar hook-length control protein; Provisional; Region: PRK10118 566546006279 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 566546006280 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 566546006281 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 566546006282 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 566546006283 flagellar motor switch protein; Validated; Region: fliN; PRK05698 566546006284 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 566546006285 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 566546006286 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 566546006287 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 566546006288 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 566546006289 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 566546006290 DNA binding residues [nucleotide binding] 566546006291 dimerization interface [polypeptide binding]; other site 566546006292 hypothetical protein; Provisional; Region: PRK10708 566546006293 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 566546006294 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 566546006295 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 566546006296 active site 566546006297 motif I; other site 566546006298 motif II; other site 566546006299 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 566546006300 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 566546006301 metal binding site [ion binding]; metal-binding site 566546006302 active site 566546006303 I-site; other site 566546006304 Uncharacterized small protein [Function unknown]; Region: COG5475 566546006305 hypothetical protein; Provisional; Region: PRK10062 566546006306 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 566546006307 EamA-like transporter family; Region: EamA; pfam00892 566546006308 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 566546006309 additional DNA contacts [nucleotide binding]; other site 566546006310 mismatch recognition site; other site 566546006311 active site 566546006312 zinc binding site [ion binding]; other site 566546006313 DNA intercalation site [nucleotide binding]; other site 566546006314 DNA cytosine methylase; Provisional; Region: PRK10458 566546006315 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 566546006316 cofactor binding site; other site 566546006317 DNA binding site [nucleotide binding] 566546006318 substrate interaction site [chemical binding]; other site 566546006319 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 566546006320 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 566546006321 Zn2+ binding site [ion binding]; other site 566546006322 Mg2+ binding site [ion binding]; other site 566546006323 pseudogene, hypothetical protein 566546006324 chaperone protein HchA; Provisional; Region: PRK04155 566546006325 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 566546006326 dimer interface [polypeptide binding]; other site 566546006327 metal binding site [ion binding]; metal-binding site 566546006328 potential oxyanion hole; other site 566546006329 potential catalytic triad [active] 566546006330 conserved cys residue [active] 566546006331 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 566546006332 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 566546006333 dimer interface [polypeptide binding]; other site 566546006334 phosphorylation site [posttranslational modification] 566546006335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546006336 ATP binding site [chemical binding]; other site 566546006337 Mg2+ binding site [ion binding]; other site 566546006338 G-X-G motif; other site 566546006339 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 566546006340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546006341 active site 566546006342 phosphorylation site [posttranslational modification] 566546006343 intermolecular recognition site; other site 566546006344 dimerization interface [polypeptide binding]; other site 566546006345 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 566546006346 DNA binding site [nucleotide binding] 566546006347 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 566546006348 active site 566546006349 homotetramer interface [polypeptide binding]; other site 566546006350 TMAO/DMSO reductase; Reviewed; Region: PRK05363 566546006351 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 566546006352 Moco binding site; other site 566546006353 metal coordination site [ion binding]; other site 566546006354 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 566546006355 zinc/cadmium-binding protein; Provisional; Region: PRK10306 566546006356 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 566546006357 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 566546006358 pseudogene, truncated adhesin 566546006359 pseudogene, putative glycosyltransferase 566546006360 shikimate transporter; Provisional; Region: PRK09952 566546006361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546006362 putative substrate translocation pore; other site 566546006363 AMP nucleosidase; Provisional; Region: PRK08292 566546006364 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 566546006365 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 566546006366 hypothetical protein; Provisional; Region: PRK12378 566546006367 MATE family multidrug exporter; Provisional; Region: PRK10189 566546006368 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 566546006369 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 566546006370 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546006371 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 566546006372 putative substrate binding site [chemical binding]; other site 566546006373 dimerization interface [polypeptide binding]; other site 566546006374 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 566546006375 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546006376 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 566546006377 putative dimerization interface [polypeptide binding]; other site 566546006378 L,D-transpeptidase; Provisional; Region: PRK10190 566546006379 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 566546006380 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 566546006381 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 566546006382 putative dimer interface [polypeptide binding]; other site 566546006383 active site pocket [active] 566546006384 putative cataytic base [active] 566546006385 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 566546006386 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 566546006387 homotrimer interface [polypeptide binding]; other site 566546006388 Walker A motif; other site 566546006389 GTP binding site [chemical binding]; other site 566546006390 Walker B motif; other site 566546006391 hypothetical protein; Provisional; Region: PRK05423 566546006392 Predicted membrane protein [Function unknown]; Region: COG1289 566546006393 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 566546006394 DNA gyrase inhibitor; Provisional; Region: PRK10016 566546006395 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 566546006396 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 566546006397 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 566546006398 exonuclease I; Provisional; Region: sbcB; PRK11779 566546006399 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 566546006400 active site 566546006401 catalytic site [active] 566546006402 substrate binding site [chemical binding]; other site 566546006403 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 566546006404 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 566546006405 CPxP motif; other site 566546006406 Sulphur transport; Region: Sulf_transp; pfam04143 566546006407 Sulphur transport; Region: Sulf_transp; pfam04143 566546006408 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 566546006409 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546006410 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 566546006411 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 566546006412 dimerization interface [polypeptide binding]; other site 566546006413 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 566546006414 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 566546006415 putative NAD(P) binding site [chemical binding]; other site 566546006416 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 566546006417 antitoxin YefM; Provisional; Region: PRK11409 566546006418 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 566546006419 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 566546006420 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 566546006421 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 566546006422 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 566546006423 NAD binding site [chemical binding]; other site 566546006424 dimerization interface [polypeptide binding]; other site 566546006425 product binding site; other site 566546006426 substrate binding site [chemical binding]; other site 566546006427 zinc binding site [ion binding]; other site 566546006428 catalytic residues [active] 566546006429 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 566546006430 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 566546006431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546006432 homodimer interface [polypeptide binding]; other site 566546006433 catalytic residue [active] 566546006434 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 566546006435 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 566546006436 active site 566546006437 motif I; other site 566546006438 motif II; other site 566546006439 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 566546006440 putative active site pocket [active] 566546006441 4-fold oligomerization interface [polypeptide binding]; other site 566546006442 metal binding residues [ion binding]; metal-binding site 566546006443 3-fold/trimer interface [polypeptide binding]; other site 566546006444 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 566546006445 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 566546006446 putative active site [active] 566546006447 oxyanion strand; other site 566546006448 catalytic triad [active] 566546006449 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 566546006450 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 566546006451 catalytic residues [active] 566546006452 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 566546006453 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 566546006454 substrate binding site [chemical binding]; other site 566546006455 glutamase interaction surface [polypeptide binding]; other site 566546006456 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 566546006457 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 566546006458 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 566546006459 metal binding site [ion binding]; metal-binding site 566546006460 chain length determinant protein WzzB; Provisional; Region: PRK15471 566546006461 Chain length determinant protein; Region: Wzz; pfam02706 566546006462 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 566546006463 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 566546006464 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 566546006465 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 566546006466 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 566546006467 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 566546006468 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 566546006469 phosphomannomutase CpsG; Provisional; Region: PRK15414 566546006470 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 566546006471 active site 566546006472 substrate binding site [chemical binding]; other site 566546006473 metal binding site [ion binding]; metal-binding site 566546006474 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 566546006475 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 566546006476 Substrate binding site; other site 566546006477 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 566546006478 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 566546006479 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 566546006480 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 566546006481 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 566546006482 NAD binding site [chemical binding]; other site 566546006483 homodimer interface [polypeptide binding]; other site 566546006484 active site 566546006485 substrate binding site [chemical binding]; other site 566546006486 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 566546006487 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 566546006488 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 566546006489 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 566546006490 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 566546006491 active site 566546006492 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 566546006493 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 566546006494 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 566546006495 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 566546006496 active site 566546006497 tetramer interface; other site 566546006498 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 566546006499 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 566546006500 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 566546006501 putative ADP-binding pocket [chemical binding]; other site 566546006502 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 566546006503 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 566546006504 colanic acid exporter; Provisional; Region: PRK10459 566546006505 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 566546006506 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 566546006507 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 566546006508 phosphomannomutase CpsG; Provisional; Region: PRK15414 566546006509 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 566546006510 active site 566546006511 substrate binding site [chemical binding]; other site 566546006512 metal binding site [ion binding]; metal-binding site 566546006513 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 566546006514 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 566546006515 Substrate binding site; other site 566546006516 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 566546006517 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 566546006518 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 566546006519 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 566546006520 active site 566546006521 GDP-Mannose binding site [chemical binding]; other site 566546006522 dimer interface [polypeptide binding]; other site 566546006523 modified nudix motif 566546006524 metal binding site [ion binding]; metal-binding site 566546006525 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 566546006526 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 566546006527 NADP binding site [chemical binding]; other site 566546006528 active site 566546006529 putative substrate binding site [chemical binding]; other site 566546006530 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 566546006531 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 566546006532 NADP-binding site; other site 566546006533 homotetramer interface [polypeptide binding]; other site 566546006534 substrate binding site [chemical binding]; other site 566546006535 homodimer interface [polypeptide binding]; other site 566546006536 active site 566546006537 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 566546006538 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 566546006539 putative trimer interface [polypeptide binding]; other site 566546006540 putative active site [active] 566546006541 putative substrate binding site [chemical binding]; other site 566546006542 putative CoA binding site [chemical binding]; other site 566546006543 putative glycosyl transferase; Provisional; Region: PRK10063 566546006544 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 566546006545 metal-binding site 566546006546 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 566546006547 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 566546006548 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 566546006549 putative acyl transferase; Provisional; Region: PRK10191 566546006550 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 566546006551 trimer interface [polypeptide binding]; other site 566546006552 active site 566546006553 substrate binding site [chemical binding]; other site 566546006554 CoA binding site [chemical binding]; other site 566546006555 putative glycosyl transferase; Provisional; Region: PRK10018 566546006556 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 566546006557 active site 566546006558 tyrosine kinase; Provisional; Region: PRK11519 566546006559 Chain length determinant protein; Region: Wzz; pfam02706 566546006560 Chain length determinant protein; Region: Wzz; cl15801 566546006561 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 566546006562 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 566546006563 Low molecular weight phosphatase family; Region: LMWPc; cd00115 566546006564 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 566546006565 active site 566546006566 polysaccharide export protein Wza; Provisional; Region: PRK15078 566546006567 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 566546006568 SLBB domain; Region: SLBB; pfam10531 566546006569 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 566546006570 FOG: CBS domain [General function prediction only]; Region: COG0517 566546006571 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 566546006572 Transporter associated domain; Region: CorC_HlyC; smart01091 566546006573 Phage-related protein [Function unknown]; Region: COG4679 566546006574 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 566546006575 putative assembly protein; Provisional; Region: PRK10833 566546006576 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 566546006577 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 566546006578 trimer interface [polypeptide binding]; other site 566546006579 active site 566546006580 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 566546006581 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 566546006582 ATP-binding site [chemical binding]; other site 566546006583 Sugar specificity; other site 566546006584 Pyrimidine base specificity; other site 566546006585 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 566546006586 putative diguanylate cyclase; Provisional; Region: PRK09776 566546006587 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 566546006588 putative active site [active] 566546006589 heme pocket [chemical binding]; other site 566546006590 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 566546006591 putative active site [active] 566546006592 heme pocket [chemical binding]; other site 566546006593 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 566546006594 putative active site [active] 566546006595 heme pocket [chemical binding]; other site 566546006596 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 566546006597 metal binding site [ion binding]; metal-binding site 566546006598 active site 566546006599 I-site; other site 566546006600 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 566546006601 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 566546006602 AlkA N-terminal domain; Region: AlkA_N; smart01009 566546006603 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 566546006604 minor groove reading motif; other site 566546006605 helix-hairpin-helix signature motif; other site 566546006606 substrate binding pocket [chemical binding]; other site 566546006607 active site 566546006608 putative chaperone; Provisional; Region: PRK11678 566546006609 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 566546006610 nucleotide binding site [chemical binding]; other site 566546006611 putative NEF/HSP70 interaction site [polypeptide binding]; other site 566546006612 SBD interface [polypeptide binding]; other site 566546006613 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 566546006614 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 566546006615 substrate binding site [chemical binding]; other site 566546006616 activation loop (A-loop); other site 566546006617 Y-family of DNA polymerases; Region: PolY; cl12025 566546006618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 566546006619 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 566546006620 Protein phosphatase 2C; Region: PP2C_2; pfam13672 566546006621 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 566546006622 metal ion-dependent adhesion site (MIDAS); other site 566546006623 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 566546006624 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 566546006625 HlyD family secretion protein; Region: HlyD_3; pfam13437 566546006626 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 566546006627 Protein export membrane protein; Region: SecD_SecF; cl14618 566546006628 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 566546006629 putative transporter; Provisional; Region: PRK10504 566546006630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546006631 putative substrate translocation pore; other site 566546006632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546006633 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 566546006634 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 566546006635 dimerization interface [polypeptide binding]; other site 566546006636 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 566546006637 dimer interface [polypeptide binding]; other site 566546006638 phosphorylation site [posttranslational modification] 566546006639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546006640 ATP binding site [chemical binding]; other site 566546006641 Mg2+ binding site [ion binding]; other site 566546006642 G-X-G motif; other site 566546006643 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 566546006644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546006645 active site 566546006646 phosphorylation site [posttranslational modification] 566546006647 intermolecular recognition site; other site 566546006648 dimerization interface [polypeptide binding]; other site 566546006649 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 566546006650 DNA binding site [nucleotide binding] 566546006651 Uncharacterized conserved protein [Function unknown]; Region: COG3422 566546006652 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 566546006653 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 566546006654 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 566546006655 putative protease; Provisional; Region: PRK15452 566546006656 Peptidase family U32; Region: Peptidase_U32; pfam01136 566546006657 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 566546006658 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 566546006659 tail protein; Provisional; Region: D; PHA02561 566546006660 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 566546006661 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 566546006662 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 566546006663 major tail tube protein; Provisional; Region: FII; PHA02600 566546006664 major tail sheath protein; Provisional; Region: FI; PHA02560 566546006665 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 566546006666 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 566546006667 catalytic residues [active] 566546006668 catalytic nucleophile [active] 566546006669 Presynaptic Site I dimer interface [polypeptide binding]; other site 566546006670 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 566546006671 Synaptic Flat tetramer interface [polypeptide binding]; other site 566546006672 Synaptic Site I dimer interface [polypeptide binding]; other site 566546006673 DNA binding site [nucleotide binding] 566546006674 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 566546006675 DNA-binding interface [nucleotide binding]; DNA binding site 566546006676 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 566546006677 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 566546006678 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 566546006679 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 566546006680 baseplate assembly protein; Provisional; Region: J; PHA02568 566546006681 baseplate wedge subunit; Provisional; Region: W; PHA02516 566546006682 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 566546006683 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 566546006684 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 566546006685 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 566546006686 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 566546006687 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 566546006688 N-acetyl-D-glucosamine binding site [chemical binding]; other site 566546006689 catalytic residue [active] 566546006690 Phage holin family 2; Region: Phage_holin_2; pfam04550 566546006691 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 566546006692 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 566546006693 terminase endonuclease subunit; Provisional; Region: M; PHA02537 566546006694 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 566546006695 Phage major capsid protein, P2 family; Region: Phage_cap_P2; pfam05125 566546006696 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929 566546006697 terminase ATPase subunit; Provisional; Region: P; PHA02535 566546006698 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 566546006699 portal vertex protein; Provisional; Region: Q; PHA02536 566546006700 Phage portal protein; Region: Phage_portal; pfam04860 566546006701 AAA domain; Region: AAA_21; pfam13304 566546006702 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 566546006703 Walker B; other site 566546006704 D-loop; other site 566546006705 H-loop/switch region; other site 566546006706 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 566546006707 DksA-like zinc finger domain containing protein; Region: PHA00080 566546006708 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 566546006709 Regulatory phage protein cox; Region: Phage_Cox; pfam10743 566546006710 integrase; Provisional; Region: int; PHA02601 566546006711 Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family. They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797 566546006712 dimer interface [polypeptide binding]; other site 566546006713 active site 566546006714 catalytic residues [active] 566546006715 Int/Topo IB signature motif; other site 566546006716 lipid kinase; Reviewed; Region: PRK13054 566546006717 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 566546006718 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 566546006719 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 566546006720 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 566546006721 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 566546006722 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 566546006723 putative NAD(P) binding site [chemical binding]; other site 566546006724 catalytic Zn binding site [ion binding]; other site 566546006725 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 566546006726 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 566546006727 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 566546006728 active site 566546006729 P-loop; other site 566546006730 phosphorylation site [posttranslational modification] 566546006731 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 566546006732 active site 566546006733 phosphorylation site [posttranslational modification] 566546006734 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 566546006735 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 566546006736 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 566546006737 intersubunit interface [polypeptide binding]; other site 566546006738 active site 566546006739 zinc binding site [ion binding]; other site 566546006740 Na+ binding site [ion binding]; other site 566546006741 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 566546006742 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 566546006743 putative active site; other site 566546006744 catalytic residue [active] 566546006745 nucleoside transporter; Region: 2A0110; TIGR00889 566546006746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546006747 putative substrate translocation pore; other site 566546006748 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 566546006749 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 566546006750 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 566546006751 substrate binding site [chemical binding]; other site 566546006752 ATP binding site [chemical binding]; other site 566546006753 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 566546006754 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 566546006755 DNA-binding site [nucleotide binding]; DNA binding site 566546006756 UTRA domain; Region: UTRA; pfam07702 566546006757 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 566546006758 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 566546006759 active site 566546006760 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 566546006761 dimer interface [polypeptide binding]; other site 566546006762 substrate binding site [chemical binding]; other site 566546006763 ATP binding site [chemical binding]; other site 566546006764 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 566546006765 substrate binding site [chemical binding]; other site 566546006766 multimerization interface [polypeptide binding]; other site 566546006767 ATP binding site [chemical binding]; other site 566546006768 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 566546006769 putative metal binding site [ion binding]; other site 566546006770 putative homodimer interface [polypeptide binding]; other site 566546006771 putative homotetramer interface [polypeptide binding]; other site 566546006772 putative homodimer-homodimer interface [polypeptide binding]; other site 566546006773 putative allosteric switch controlling residues; other site 566546006774 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 566546006775 Predicted integral membrane protein [Function unknown]; Region: COG5455 566546006776 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 566546006777 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 566546006778 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 566546006779 PapC N-terminal domain; Region: PapC_N; pfam13954 566546006780 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 566546006781 PapC C-terminal domain; Region: PapC_C; pfam13953 566546006782 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 566546006783 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 566546006784 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 566546006785 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 566546006786 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 566546006787 antiporter inner membrane protein; Provisional; Region: PRK11670 566546006788 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 566546006789 Walker A motif; other site 566546006790 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 566546006791 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 566546006792 active site 566546006793 HIGH motif; other site 566546006794 KMSKS motif; other site 566546006795 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 566546006796 tRNA binding surface [nucleotide binding]; other site 566546006797 anticodon binding site; other site 566546006798 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 566546006799 dimer interface [polypeptide binding]; other site 566546006800 putative tRNA-binding site [nucleotide binding]; other site 566546006801 pseudogene, WGR domain-containing protein 566546006802 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 566546006803 MoxR-like ATPases [General function prediction only]; Region: COG0714 566546006804 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546006805 Walker A motif; other site 566546006806 ATP binding site [chemical binding]; other site 566546006807 Walker B motif; other site 566546006808 arginine finger; other site 566546006809 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 566546006810 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 566546006811 metal ion-dependent adhesion site (MIDAS); other site 566546006812 pseudogene, conserved hypothetical protein 566546006813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 566546006814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 566546006815 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 566546006816 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 566546006817 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 566546006818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546006819 active site 566546006820 phosphorylation site [posttranslational modification] 566546006821 intermolecular recognition site; other site 566546006822 dimerization interface [polypeptide binding]; other site 566546006823 LytTr DNA-binding domain; Region: LytTR; pfam04397 566546006824 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 566546006825 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 566546006826 GAF domain; Region: GAF; pfam01590 566546006827 Histidine kinase; Region: His_kinase; pfam06580 566546006828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546006829 ATP binding site [chemical binding]; other site 566546006830 Mg2+ binding site [ion binding]; other site 566546006831 G-X-G motif; other site 566546006832 transcriptional regulator MirA; Provisional; Region: PRK15043 566546006833 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 566546006834 DNA binding residues [nucleotide binding] 566546006835 hypothetical protein; Provisional; Region: PRK13681 566546006836 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 566546006837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546006838 dimer interface [polypeptide binding]; other site 566546006839 conserved gate region; other site 566546006840 putative PBP binding loops; other site 566546006841 ABC-ATPase subunit interface; other site 566546006842 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 566546006843 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 566546006844 Walker A/P-loop; other site 566546006845 ATP binding site [chemical binding]; other site 566546006846 Q-loop/lid; other site 566546006847 ABC transporter signature motif; other site 566546006848 Walker B; other site 566546006849 D-loop; other site 566546006850 H-loop/switch region; other site 566546006851 CBS domain; Region: CBS; pfam00571 566546006852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546006853 dimer interface [polypeptide binding]; other site 566546006854 conserved gate region; other site 566546006855 ABC-ATPase subunit interface; other site 566546006856 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 566546006857 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 566546006858 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 566546006859 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 566546006860 D-lactate dehydrogenase; Provisional; Region: PRK11183 566546006861 FAD binding domain; Region: FAD_binding_4; pfam01565 566546006862 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 566546006863 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 566546006864 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 566546006865 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 566546006866 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 566546006867 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 566546006868 oxidoreductase; Provisional; Region: PRK12743 566546006869 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 566546006870 NAD(P) binding site [chemical binding]; other site 566546006871 active site 566546006872 pseudogene, conserved protein 566546006873 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 566546006874 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 566546006875 FMN binding site [chemical binding]; other site 566546006876 active site 566546006877 catalytic residues [active] 566546006878 substrate binding site [chemical binding]; other site 566546006879 hypothetical protein; Provisional; Region: PRK01821 566546006880 hypothetical protein; Provisional; Region: PRK10711 566546006881 cytidine deaminase; Provisional; Region: PRK09027 566546006882 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 566546006883 active site 566546006884 catalytic motif [active] 566546006885 Zn binding site [ion binding]; other site 566546006886 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 566546006887 active site 566546006888 catalytic motif [active] 566546006889 Zn binding site [ion binding]; other site 566546006890 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 566546006891 putative active site [active] 566546006892 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 566546006893 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 566546006894 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 566546006895 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 566546006896 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 566546006897 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 566546006898 homodimer interface [polypeptide binding]; other site 566546006899 active site 566546006900 FMN binding site [chemical binding]; other site 566546006901 substrate binding site [chemical binding]; other site 566546006902 4Fe-4S binding domain; Region: Fer4; pfam00037 566546006903 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 566546006904 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 566546006905 TM-ABC transporter signature motif; other site 566546006906 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 566546006907 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 566546006908 Walker A/P-loop; other site 566546006909 ATP binding site [chemical binding]; other site 566546006910 Q-loop/lid; other site 566546006911 ABC transporter signature motif; other site 566546006912 Walker B; other site 566546006913 D-loop; other site 566546006914 H-loop/switch region; other site 566546006915 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 566546006916 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 566546006917 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 566546006918 ligand binding site [chemical binding]; other site 566546006919 calcium binding site [ion binding]; other site 566546006920 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 566546006921 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 566546006922 DNA binding site [nucleotide binding] 566546006923 domain linker motif; other site 566546006924 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 566546006925 dimerization interface (closed form) [polypeptide binding]; other site 566546006926 ligand binding site [chemical binding]; other site 566546006927 Predicted membrane protein [Function unknown]; Region: COG2311 566546006928 hypothetical protein; Provisional; Region: PRK10835 566546006929 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 566546006930 homodecamer interface [polypeptide binding]; other site 566546006931 GTP cyclohydrolase I; Provisional; Region: PLN03044 566546006932 active site 566546006933 putative catalytic site residues [active] 566546006934 zinc binding site [ion binding]; other site 566546006935 GTP-CH-I/GFRP interaction surface; other site 566546006936 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 566546006937 S-formylglutathione hydrolase; Region: PLN02442 566546006938 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 566546006939 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 566546006940 N-terminal plug; other site 566546006941 ligand-binding site [chemical binding]; other site 566546006942 lysine transporter; Provisional; Region: PRK10836 566546006943 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 566546006944 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546006945 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 566546006946 putative dimerization interface [polypeptide binding]; other site 566546006947 conserved hypothetical integral membrane protein; Region: TIGR00698 566546006948 endonuclease IV; Provisional; Region: PRK01060 566546006949 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 566546006950 AP (apurinic/apyrimidinic) site pocket; other site 566546006951 DNA interaction; other site 566546006952 Metal-binding active site; metal-binding site 566546006953 putative kinase; Provisional; Region: PRK09954 566546006954 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 566546006955 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 566546006956 substrate binding site [chemical binding]; other site 566546006957 ATP binding site [chemical binding]; other site 566546006958 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 566546006959 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 566546006960 Nucleoside recognition; Region: Gate; pfam07670 566546006961 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 566546006962 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 566546006963 active site 566546006964 tetramer interface [polypeptide binding]; other site 566546006965 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 566546006966 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 566546006967 ligand binding site [chemical binding]; other site 566546006968 flexible hinge region; other site 566546006969 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 566546006970 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 566546006971 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 566546006972 Nucleoside recognition; Region: Gate; pfam07670 566546006973 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 566546006974 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 566546006975 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 566546006976 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 566546006977 substrate binding site [chemical binding]; other site 566546006978 ATP binding site [chemical binding]; other site 566546006979 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 566546006980 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 566546006981 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 566546006982 active site 566546006983 P-loop; other site 566546006984 phosphorylation site [posttranslational modification] 566546006985 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 566546006986 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 566546006987 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 566546006988 putative substrate binding site [chemical binding]; other site 566546006989 putative ATP binding site [chemical binding]; other site 566546006990 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 566546006991 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 566546006992 active site 566546006993 phosphorylation site [posttranslational modification] 566546006994 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 566546006995 dimerization domain swap beta strand [polypeptide binding]; other site 566546006996 regulatory protein interface [polypeptide binding]; other site 566546006997 active site 566546006998 regulatory phosphorylation site [posttranslational modification]; other site 566546006999 sugar efflux transporter B; Provisional; Region: PRK15011 566546007000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546007001 putative substrate translocation pore; other site 566546007002 Flagellin N-methylase; Region: FliB; pfam03692 566546007003 elongation factor P; Provisional; Region: PRK04542 566546007004 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 566546007005 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 566546007006 RNA binding site [nucleotide binding]; other site 566546007007 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 566546007008 RNA binding site [nucleotide binding]; other site 566546007009 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 566546007010 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 566546007011 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 566546007012 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 566546007013 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 566546007014 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 566546007015 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 566546007016 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 566546007017 active site 566546007018 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 566546007019 NlpC/P60 family; Region: NLPC_P60; pfam00877 566546007020 phage resistance protein; Provisional; Region: PRK10551 566546007021 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 566546007022 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 566546007023 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 566546007024 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 566546007025 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 566546007026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546007027 dimer interface [polypeptide binding]; other site 566546007028 conserved gate region; other site 566546007029 putative PBP binding loops; other site 566546007030 ABC-ATPase subunit interface; other site 566546007031 microcin C ABC transporter permease; Provisional; Region: PRK15021 566546007032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546007033 dimer interface [polypeptide binding]; other site 566546007034 conserved gate region; other site 566546007035 ABC-ATPase subunit interface; other site 566546007036 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 566546007037 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 566546007038 Walker A/P-loop; other site 566546007039 ATP binding site [chemical binding]; other site 566546007040 Q-loop/lid; other site 566546007041 ABC transporter signature motif; other site 566546007042 Walker B; other site 566546007043 D-loop; other site 566546007044 H-loop/switch region; other site 566546007045 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 566546007046 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 566546007047 Walker A/P-loop; other site 566546007048 ATP binding site [chemical binding]; other site 566546007049 Q-loop/lid; other site 566546007050 ABC transporter signature motif; other site 566546007051 Walker B; other site 566546007052 D-loop; other site 566546007053 H-loop/switch region; other site 566546007054 hypothetical protein; Provisional; Region: PRK11835 566546007055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546007056 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 566546007057 putative substrate translocation pore; other site 566546007058 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 566546007059 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 566546007060 RNA binding surface [nucleotide binding]; other site 566546007061 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 566546007062 active site 566546007063 uracil binding [chemical binding]; other site 566546007064 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 566546007065 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 566546007066 ATP binding site [chemical binding]; other site 566546007067 putative Mg++ binding site [ion binding]; other site 566546007068 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 566546007069 nucleotide binding region [chemical binding]; other site 566546007070 ATP-binding site [chemical binding]; other site 566546007071 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 566546007072 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 566546007073 5S rRNA interface [nucleotide binding]; other site 566546007074 CTC domain interface [polypeptide binding]; other site 566546007075 L16 interface [polypeptide binding]; other site 566546007076 Nucleoid-associated protein [General function prediction only]; Region: COG3081 566546007077 nucleoid-associated protein NdpA; Validated; Region: PRK00378 566546007078 hypothetical protein; Provisional; Region: PRK13689 566546007079 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 566546007080 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 566546007081 Sulfatase; Region: Sulfatase; pfam00884 566546007082 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 566546007083 hypothetical protein; Provisional; Region: PRK09945 566546007084 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 566546007085 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 566546007086 Autotransporter beta-domain; Region: Autotransporter; pfam03797 566546007087 transcriptional regulator NarP; Provisional; Region: PRK10403 566546007088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546007089 active site 566546007090 phosphorylation site [posttranslational modification] 566546007091 intermolecular recognition site; other site 566546007092 dimerization interface [polypeptide binding]; other site 566546007093 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 566546007094 DNA binding residues [nucleotide binding] 566546007095 dimerization interface [polypeptide binding]; other site 566546007096 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 566546007097 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 566546007098 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 566546007099 binding surface 566546007100 TPR motif; other site 566546007101 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 566546007102 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 566546007103 catalytic residues [active] 566546007104 central insert; other site 566546007105 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 566546007106 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 566546007107 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 566546007108 heme exporter protein CcmC; Region: ccmC; TIGR01191 566546007109 heme exporter protein CcmB; Region: ccmB; TIGR01190 566546007110 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 566546007111 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 566546007112 Walker A/P-loop; other site 566546007113 ATP binding site [chemical binding]; other site 566546007114 Q-loop/lid; other site 566546007115 ABC transporter signature motif; other site 566546007116 Walker B; other site 566546007117 D-loop; other site 566546007118 H-loop/switch region; other site 566546007119 cytochrome c-type protein NapC; Provisional; Region: PRK10617 566546007120 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 566546007121 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 566546007122 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 566546007123 4Fe-4S binding domain; Region: Fer4_5; pfam12801 566546007124 4Fe-4S binding domain; Region: Fer4_6; pfam12837 566546007125 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 566546007126 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 566546007127 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 566546007128 [4Fe-4S] binding site [ion binding]; other site 566546007129 molybdopterin cofactor binding site; other site 566546007130 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 566546007131 molybdopterin cofactor binding site; other site 566546007132 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 566546007133 ferredoxin-type protein; Provisional; Region: PRK10194 566546007134 tRNA synthetases class I (R); Region: tRNA-synt_1d; pfam00750 566546007135 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 566546007136 secondary substrate binding site; other site 566546007137 primary substrate binding site; other site 566546007138 inhibition loop; other site 566546007139 dimerization interface [polypeptide binding]; other site 566546007140 malate:quinone oxidoreductase; Validated; Region: PRK05257 566546007141 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 566546007142 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 566546007143 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 566546007144 Walker A/P-loop; other site 566546007145 ATP binding site [chemical binding]; other site 566546007146 Q-loop/lid; other site 566546007147 ABC transporter signature motif; other site 566546007148 Walker B; other site 566546007149 D-loop; other site 566546007150 H-loop/switch region; other site 566546007151 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 566546007152 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 566546007153 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 566546007154 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546007155 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546007156 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 566546007157 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 566546007158 DNA binding site [nucleotide binding] 566546007159 active site 566546007160 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 566546007161 ApbE family; Region: ApbE; pfam02424 566546007162 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 566546007163 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 566546007164 trimer interface [polypeptide binding]; other site 566546007165 eyelet of channel; other site 566546007166 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 566546007167 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546007168 ATP binding site [chemical binding]; other site 566546007169 G-X-G motif; other site 566546007170 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 566546007171 putative binding surface; other site 566546007172 active site 566546007173 transcriptional regulator RcsB; Provisional; Region: PRK10840 566546007174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546007175 active site 566546007176 phosphorylation site [posttranslational modification] 566546007177 intermolecular recognition site; other site 566546007178 dimerization interface [polypeptide binding]; other site 566546007179 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 566546007180 DNA binding residues [nucleotide binding] 566546007181 dimerization interface [polypeptide binding]; other site 566546007182 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 566546007183 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 566546007184 dimer interface [polypeptide binding]; other site 566546007185 phosphorylation site [posttranslational modification] 566546007186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546007187 ATP binding site [chemical binding]; other site 566546007188 Mg2+ binding site [ion binding]; other site 566546007189 G-X-G motif; other site 566546007190 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 566546007191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546007192 active site 566546007193 phosphorylation site [posttranslational modification] 566546007194 intermolecular recognition site; other site 566546007195 dimerization interface [polypeptide binding]; other site 566546007196 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 566546007197 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 566546007198 Predicted secreted protein [Function unknown]; Region: COG5445 566546007199 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 566546007200 Predicted secreted protein [Function unknown]; Region: COG5445 566546007201 Stage II sporulation protein; Region: SpoIID; pfam08486 566546007202 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 566546007203 pseudogene, hypothetical protein 566546007204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 566546007205 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 566546007206 DNA gyrase subunit A; Validated; Region: PRK05560 566546007207 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 566546007208 CAP-like domain; other site 566546007209 active site 566546007210 primary dimer interface [polypeptide binding]; other site 566546007211 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 566546007212 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 566546007213 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 566546007214 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 566546007215 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 566546007216 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 566546007217 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 566546007218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546007219 S-adenosylmethionine binding site [chemical binding]; other site 566546007220 adhesin; Provisional; Region: PRK09752 566546007221 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 566546007222 Autotransporter beta-domain; Region: Autotransporter; pfam03797 566546007223 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 566546007224 ATP cone domain; Region: ATP-cone; pfam03477 566546007225 Class I ribonucleotide reductase; Region: RNR_I; cd01679 566546007226 active site 566546007227 dimer interface [polypeptide binding]; other site 566546007228 catalytic residues [active] 566546007229 effector binding site; other site 566546007230 R2 peptide binding site; other site 566546007231 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 566546007232 dimer interface [polypeptide binding]; other site 566546007233 putative radical transfer pathway; other site 566546007234 diiron center [ion binding]; other site 566546007235 tyrosyl radical; other site 566546007236 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 566546007237 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 566546007238 catalytic loop [active] 566546007239 iron binding site [ion binding]; other site 566546007240 hypothetical protein; Provisional; Region: PRK09902 566546007241 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 566546007242 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 566546007243 active site 566546007244 catalytic site [active] 566546007245 metal binding site [ion binding]; metal-binding site 566546007246 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 566546007247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546007248 putative substrate translocation pore; other site 566546007249 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 566546007250 hydroxyglutarate oxidase; Provisional; Region: PRK11728 566546007251 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 566546007252 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 566546007253 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 566546007254 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 566546007255 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 566546007256 Cysteine-rich domain; Region: CCG; pfam02754 566546007257 Cysteine-rich domain; Region: CCG; pfam02754 566546007258 hypothetical protein; Provisional; Region: PRK09956 566546007259 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 566546007260 pseudogene, hypothetical protein 566546007261 hypothetical protein; Provisional; Region: PRK03673 566546007262 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 566546007263 putative MPT binding site; other site 566546007264 Competence-damaged protein; Region: CinA; cl00666 566546007265 YfaZ precursor; Region: YfaZ; pfam07437 566546007266 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 566546007267 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 566546007268 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 566546007269 catalytic core [active] 566546007270 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 566546007271 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 566546007272 inhibitor-cofactor binding pocket; inhibition site 566546007273 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546007274 catalytic residue [active] 566546007275 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 566546007276 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 566546007277 Ligand binding site; other site 566546007278 Putative Catalytic site; other site 566546007279 DXD motif; other site 566546007280 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 566546007281 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 566546007282 substrate binding site [chemical binding]; other site 566546007283 cosubstrate binding site; other site 566546007284 catalytic site [active] 566546007285 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 566546007286 active site 566546007287 hexamer interface [polypeptide binding]; other site 566546007288 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 566546007289 NAD binding site [chemical binding]; other site 566546007290 substrate binding site [chemical binding]; other site 566546007291 active site 566546007292 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 566546007293 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 566546007294 putative active site [active] 566546007295 putative catalytic site [active] 566546007296 putative Zn binding site [ion binding]; other site 566546007297 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 566546007298 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 566546007299 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 566546007300 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 566546007301 signal transduction protein PmrD; Provisional; Region: PRK15450 566546007302 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 566546007303 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 566546007304 acyl-activating enzyme (AAE) consensus motif; other site 566546007305 putative AMP binding site [chemical binding]; other site 566546007306 putative active site [active] 566546007307 putative CoA binding site [chemical binding]; other site 566546007308 O-succinylbenzoate synthase; Provisional; Region: PRK05105 566546007309 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 566546007310 active site 566546007311 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 566546007312 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 566546007313 substrate binding site [chemical binding]; other site 566546007314 oxyanion hole (OAH) forming residues; other site 566546007315 trimer interface [polypeptide binding]; other site 566546007316 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 566546007317 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 566546007318 nucleophilic elbow; other site 566546007319 catalytic triad; other site 566546007320 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 566546007321 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 566546007322 dimer interface [polypeptide binding]; other site 566546007323 tetramer interface [polypeptide binding]; other site 566546007324 PYR/PP interface [polypeptide binding]; other site 566546007325 TPP binding site [chemical binding]; other site 566546007326 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 566546007327 TPP-binding site; other site 566546007328 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 566546007329 isochorismate synthases; Region: isochor_syn; TIGR00543 566546007330 hypothetical protein; Provisional; Region: PRK10404 566546007331 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 566546007332 Coenzyme A binding pocket [chemical binding]; other site 566546007333 ribonuclease BN; Region: true_RNase_BN; TIGR02649 566546007334 deubiquitinase; Provisional; Region: PRK11836 566546007335 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 566546007336 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 566546007337 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 566546007338 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 566546007339 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 566546007340 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 566546007341 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 566546007342 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 566546007343 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 566546007344 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 566546007345 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 566546007346 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 566546007347 4Fe-4S binding domain; Region: Fer4; pfam00037 566546007348 4Fe-4S binding domain; Region: Fer4; pfam00037 566546007349 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 566546007350 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 566546007351 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 566546007352 catalytic loop [active] 566546007353 iron binding site [ion binding]; other site 566546007354 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 566546007355 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 566546007356 [4Fe-4S] binding site [ion binding]; other site 566546007357 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 566546007358 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 566546007359 SLBB domain; Region: SLBB; pfam10531 566546007360 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 566546007361 NADH dehydrogenase subunit E; Validated; Region: PRK07539 566546007362 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 566546007363 putative dimer interface [polypeptide binding]; other site 566546007364 [2Fe-2S] cluster binding site [ion binding]; other site 566546007365 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 566546007366 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 566546007367 NADH dehydrogenase subunit D; Validated; Region: PRK06075 566546007368 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 566546007369 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 566546007370 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 566546007371 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546007372 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 566546007373 putative dimerization interface [polypeptide binding]; other site 566546007374 aminotransferase AlaT; Validated; Region: PRK09265 566546007375 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 566546007376 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546007377 homodimer interface [polypeptide binding]; other site 566546007378 catalytic residue [active] 566546007379 5'-nucleotidase; Provisional; Region: PRK03826 566546007380 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 566546007381 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 566546007382 TrkA-C domain; Region: TrkA_C; pfam02080 566546007383 TrkA-C domain; Region: TrkA_C; pfam02080 566546007384 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 566546007385 putative phosphatase; Provisional; Region: PRK11587 566546007386 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 566546007387 motif II; other site 566546007388 hypothetical protein; Validated; Region: PRK05445 566546007389 hypothetical protein; Provisional; Region: PRK01816 566546007390 propionate/acetate kinase; Provisional; Region: PRK12379 566546007391 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 566546007392 phosphate acetyltransferase; Reviewed; Region: PRK05632 566546007393 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 566546007394 DRTGG domain; Region: DRTGG; pfam07085 566546007395 phosphate acetyltransferase; Region: pta; TIGR00651 566546007396 hypothetical protein; Provisional; Region: PRK11588 566546007397 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 566546007398 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 566546007399 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 566546007400 nudix motif; other site 566546007401 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 566546007402 active site 566546007403 metal binding site [ion binding]; metal-binding site 566546007404 homotetramer interface [polypeptide binding]; other site 566546007405 glutathione S-transferase; Provisional; Region: PRK15113 566546007406 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 566546007407 C-terminal domain interface [polypeptide binding]; other site 566546007408 GSH binding site (G-site) [chemical binding]; other site 566546007409 dimer interface [polypeptide binding]; other site 566546007410 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 566546007411 N-terminal domain interface [polypeptide binding]; other site 566546007412 putative dimer interface [polypeptide binding]; other site 566546007413 putative substrate binding pocket (H-site) [chemical binding]; other site 566546007414 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 566546007415 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 566546007416 C-terminal domain interface [polypeptide binding]; other site 566546007417 GSH binding site (G-site) [chemical binding]; other site 566546007418 dimer interface [polypeptide binding]; other site 566546007419 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 566546007420 N-terminal domain interface [polypeptide binding]; other site 566546007421 putative dimer interface [polypeptide binding]; other site 566546007422 active site 566546007423 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 566546007424 homooctamer interface [polypeptide binding]; other site 566546007425 active site 566546007426 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 566546007427 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 566546007428 putative NAD(P) binding site [chemical binding]; other site 566546007429 putative active site [active] 566546007430 putative transposase; Provisional; Region: PRK09857 566546007431 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 566546007432 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 566546007433 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 566546007434 Walker A/P-loop; other site 566546007435 ATP binding site [chemical binding]; other site 566546007436 Q-loop/lid; other site 566546007437 ABC transporter signature motif; other site 566546007438 Walker B; other site 566546007439 D-loop; other site 566546007440 H-loop/switch region; other site 566546007441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546007442 dimer interface [polypeptide binding]; other site 566546007443 conserved gate region; other site 566546007444 putative PBP binding loops; other site 566546007445 ABC-ATPase subunit interface; other site 566546007446 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 566546007447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546007448 dimer interface [polypeptide binding]; other site 566546007449 conserved gate region; other site 566546007450 putative PBP binding loops; other site 566546007451 ABC-ATPase subunit interface; other site 566546007452 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 566546007453 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 566546007454 substrate binding pocket [chemical binding]; other site 566546007455 membrane-bound complex binding site; other site 566546007456 hinge residues; other site 566546007457 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 566546007458 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 566546007459 substrate binding pocket [chemical binding]; other site 566546007460 membrane-bound complex binding site; other site 566546007461 hinge residues; other site 566546007462 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 566546007463 Flavoprotein; Region: Flavoprotein; pfam02441 566546007464 amidophosphoribosyltransferase; Provisional; Region: PRK09246 566546007465 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 566546007466 active site 566546007467 tetramer interface [polypeptide binding]; other site 566546007468 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 566546007469 active site 566546007470 colicin V production protein; Provisional; Region: PRK10845 566546007471 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 566546007472 cell division protein DedD; Provisional; Region: PRK11633 566546007473 Sporulation related domain; Region: SPOR; pfam05036 566546007474 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 566546007475 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 566546007476 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 566546007477 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 566546007478 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 566546007479 hypothetical protein; Provisional; Region: PRK10847 566546007480 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 566546007481 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 566546007482 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 566546007483 dimerization interface 3.5A [polypeptide binding]; other site 566546007484 active site 566546007485 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 566546007486 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 566546007487 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 566546007488 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 566546007489 ligand binding site [chemical binding]; other site 566546007490 NAD binding site [chemical binding]; other site 566546007491 catalytic site [active] 566546007492 homodimer interface [polypeptide binding]; other site 566546007493 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 566546007494 putative transporter; Provisional; Region: PRK12382 566546007495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546007496 putative substrate translocation pore; other site 566546007497 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 566546007498 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 566546007499 dimer interface [polypeptide binding]; other site 566546007500 active site 566546007501 Uncharacterized conserved protein [Function unknown]; Region: COG4121 566546007502 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 566546007503 YfcL protein; Region: YfcL; pfam08891 566546007504 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 566546007505 hypothetical protein; Provisional; Region: PRK10621 566546007506 Predicted permeases [General function prediction only]; Region: COG0730 566546007507 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 566546007508 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 566546007509 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 566546007510 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 566546007511 Tetramer interface [polypeptide binding]; other site 566546007512 active site 566546007513 FMN-binding site [chemical binding]; other site 566546007514 HemK family putative methylases; Region: hemK_fam; TIGR00536 566546007515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546007516 S-adenosylmethionine binding site [chemical binding]; other site 566546007517 hypothetical protein; Provisional; Region: PRK04946 566546007518 Smr domain; Region: Smr; pfam01713 566546007519 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 566546007520 Fimbrial protein; Region: Fimbrial; cl01416 566546007521 Fimbrial protein; Region: Fimbrial; cl01416 566546007522 Fimbrial protein; Region: Fimbrial; cl01416 566546007523 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 566546007524 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 566546007525 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 566546007526 PapC N-terminal domain; Region: PapC_N; pfam13954 566546007527 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 566546007528 PapC C-terminal domain; Region: PapC_C; pfam13953 566546007529 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 566546007530 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 566546007531 catalytic core [active] 566546007532 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 566546007533 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 566546007534 substrate binding site [chemical binding]; other site 566546007535 oxyanion hole (OAH) forming residues; other site 566546007536 trimer interface [polypeptide binding]; other site 566546007537 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 566546007538 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 566546007539 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 566546007540 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 566546007541 dimer interface [polypeptide binding]; other site 566546007542 active site 566546007543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 566546007544 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 566546007545 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 566546007546 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 566546007547 integrase; Provisional; Region: PRK09692 566546007548 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 566546007549 active site 566546007550 Int/Topo IB signature motif; other site 566546007551 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 566546007552 Head binding; Region: Head_binding; pfam09008 566546007553 Mnt; Region: mnt; PHA01513 566546007554 Arc-like DNA binding domain; Region: Arc; pfam03869 566546007555 Regulatory protein Mnt; Region: Repressor_Mnt; pfam11423 566546007556 Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; Region: DM14; smart00685 566546007557 Protein of unknown function (DUF2824); Region: DUF2824; pfam11039 566546007558 Vitamin-D-receptor interacting Mediator subunit 4; Region: Med4; pfam10018 566546007559 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 566546007560 P22 tail accessory factor; Region: P22_Tail-4; pfam11650 566546007561 coat protein; Region: PHA01511 566546007562 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 566546007563 Bacteriophage, scaffolding protein; Region: Phage-scaffold; pfam09306 566546007564 Terminase-like family; Region: Terminase_6; pfam03237 566546007565 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 566546007566 Protein of unknown function (DUF2560); Region: DUF2560; pfam10834 566546007567 T5orf172 domain; Region: T5orf172; pfam10544 566546007568 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 566546007569 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 566546007570 N-acetyl-D-glucosamine binding site [chemical binding]; other site 566546007571 catalytic residue [active] 566546007572 phage holin, lambda family; Region: holin_lambda; TIGR01594 566546007573 Antitermination protein; Region: Antiterm; pfam03589 566546007574 Antitermination protein; Region: Antiterm; pfam03589 566546007575 Phage NinH protein; Region: Phage_NinH; pfam06322 566546007576 Endodeoxyribonuclease RusA; Region: RusA; cl01885 566546007577 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 566546007578 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 566546007579 NinF protein; Region: NinF; pfam05810 566546007580 Protein of unknown function (DUF2591); Region: DUF2591; pfam10765 566546007581 phage N-6-adenine-methyltransferase; Region: phage_N6A_met; TIGR01712 566546007582 NinB protein; Region: NinB; pfam05772 566546007583 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 566546007584 phage replicative helicase, DnaB family, HK022 subfamily; Region: phage_DnaB; TIGR03600 566546007585 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 566546007586 Walker A motif; other site 566546007587 ATP binding site [chemical binding]; other site 566546007588 Walker B motif; other site 566546007589 Protein of unknown function (DUF2740); Region: DUF2740; pfam10872 566546007590 Bacteriophage CII protein; Region: Phage_CII; pfam05269 566546007591 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 566546007592 non-specific DNA binding site [nucleotide binding]; other site 566546007593 salt bridge; other site 566546007594 sequence-specific DNA binding site [nucleotide binding]; other site 566546007595 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 566546007596 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 566546007597 non-specific DNA binding site [nucleotide binding]; other site 566546007598 salt bridge; other site 566546007599 sequence-specific DNA binding site [nucleotide binding]; other site 566546007600 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 566546007601 Catalytic site [active] 566546007602 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 566546007603 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 566546007604 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 566546007605 dimer interface [polypeptide binding]; other site 566546007606 ssDNA binding site [nucleotide binding]; other site 566546007607 tetramer (dimer of dimers) interface [polypeptide binding]; other site 566546007608 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 566546007609 active site 566546007610 catalytic site [active] 566546007611 substrate binding site [chemical binding]; other site 566546007612 Protein of unknown function (DUF2856); Region: DUF2856; pfam11043 566546007613 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 566546007614 Protein of unknown function (DUF551); Region: DUF551; pfam04448 566546007615 The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain; Region: ASCH; smart01022 566546007616 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 566546007617 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 566546007618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546007619 putative substrate translocation pore; other site 566546007620 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 566546007621 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 566546007622 putative substrate binding site [chemical binding]; other site 566546007623 putative ATP binding site [chemical binding]; other site 566546007624 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 566546007625 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 566546007626 substrate binding [chemical binding]; other site 566546007627 active site 566546007628 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 566546007629 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 566546007630 DNA binding site [nucleotide binding] 566546007631 domain linker motif; other site 566546007632 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 566546007633 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 566546007634 putative dimerization interface [polypeptide binding]; other site 566546007635 putative ligand binding site [chemical binding]; other site 566546007636 pseudogene, truncated predicted transporter 566546007637 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 566546007638 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 566546007639 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 566546007640 catalytic residue [active] 566546007641 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 566546007642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546007643 putative substrate translocation pore; other site 566546007644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546007645 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 566546007646 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 566546007647 HlyD family secretion protein; Region: HlyD_3; pfam13437 566546007648 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 566546007649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546007650 active site 566546007651 phosphorylation site [posttranslational modification] 566546007652 intermolecular recognition site; other site 566546007653 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 566546007654 DNA binding residues [nucleotide binding] 566546007655 dimerization interface [polypeptide binding]; other site 566546007656 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 566546007657 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 566546007658 substrate binding pocket [chemical binding]; other site 566546007659 membrane-bound complex binding site; other site 566546007660 hinge residues; other site 566546007661 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 566546007662 substrate binding pocket [chemical binding]; other site 566546007663 membrane-bound complex binding site; other site 566546007664 hinge residues; other site 566546007665 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 566546007666 dimer interface [polypeptide binding]; other site 566546007667 phosphorylation site [posttranslational modification] 566546007668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546007669 ATP binding site [chemical binding]; other site 566546007670 Mg2+ binding site [ion binding]; other site 566546007671 G-X-G motif; other site 566546007672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546007673 active site 566546007674 phosphorylation site [posttranslational modification] 566546007675 intermolecular recognition site; other site 566546007676 dimerization interface [polypeptide binding]; other site 566546007677 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 566546007678 putative binding surface; other site 566546007679 active site 566546007680 putative CoA-transferase; Provisional; Region: PRK11430 566546007681 CoA-transferase family III; Region: CoA_transf_3; pfam02515 566546007682 putative transporter YfdV; Provisional; Region: PRK09903 566546007683 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 566546007684 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 566546007685 PYR/PP interface [polypeptide binding]; other site 566546007686 dimer interface [polypeptide binding]; other site 566546007687 TPP binding site [chemical binding]; other site 566546007688 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 566546007689 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 566546007690 TPP-binding site; other site 566546007691 dimer interface [polypeptide binding]; other site 566546007692 formyl-coenzyme A transferase; Provisional; Region: PRK05398 566546007693 CoA-transferase family III; Region: CoA_transf_3; pfam02515 566546007694 hypothetical protein; Provisional; Region: PRK10316 566546007695 YfdX protein; Region: YfdX; pfam10938 566546007696 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 566546007697 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 566546007698 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 566546007699 putative acyl-acceptor binding pocket; other site 566546007700 aminotransferase; Validated; Region: PRK08175 566546007701 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 566546007702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546007703 homodimer interface [polypeptide binding]; other site 566546007704 catalytic residue [active] 566546007705 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 566546007706 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 566546007707 GAF domain; Region: GAF; pfam01590 566546007708 Histidine kinase; Region: His_kinase; pfam06580 566546007709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546007710 ATP binding site [chemical binding]; other site 566546007711 Mg2+ binding site [ion binding]; other site 566546007712 G-X-G motif; other site 566546007713 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 566546007714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546007715 active site 566546007716 phosphorylation site [posttranslational modification] 566546007717 intermolecular recognition site; other site 566546007718 dimerization interface [polypeptide binding]; other site 566546007719 LytTr DNA-binding domain; Region: LytTR; pfam04397 566546007720 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 566546007721 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546007722 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 566546007723 dimerization domain swap beta strand [polypeptide binding]; other site 566546007724 regulatory protein interface [polypeptide binding]; other site 566546007725 active site 566546007726 regulatory phosphorylation site [posttranslational modification]; other site 566546007727 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 566546007728 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 566546007729 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 566546007730 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 566546007731 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 566546007732 active site 566546007733 phosphorylation site [posttranslational modification] 566546007734 exoaminopeptidase; Provisional; Region: PRK09961 566546007735 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 566546007736 oligomer interface [polypeptide binding]; other site 566546007737 active site 566546007738 metal binding site [ion binding]; metal-binding site 566546007739 aminopeptidase; Provisional; Region: PRK09795 566546007740 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 566546007741 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 566546007742 active site 566546007743 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 566546007744 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 566546007745 active site 566546007746 P-loop; other site 566546007747 phosphorylation site [posttranslational modification] 566546007748 glucokinase, proteobacterial type; Region: glk; TIGR00749 566546007749 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 566546007750 nucleotide binding site [chemical binding]; other site 566546007751 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 566546007752 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 566546007753 Cl- selectivity filter; other site 566546007754 Cl- binding residues [ion binding]; other site 566546007755 pore gating glutamate residue; other site 566546007756 dimer interface [polypeptide binding]; other site 566546007757 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 566546007758 manganese transport protein MntH; Reviewed; Region: PRK00701 566546007759 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 566546007760 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 566546007761 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 566546007762 Nucleoside recognition; Region: Gate; pfam07670 566546007763 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 566546007764 MASE1; Region: MASE1; pfam05231 566546007765 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 566546007766 diguanylate cyclase; Region: GGDEF; smart00267 566546007767 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 566546007768 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 566546007769 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 566546007770 salt bridge; other site 566546007771 non-specific DNA binding site [nucleotide binding]; other site 566546007772 sequence-specific DNA binding site [nucleotide binding]; other site 566546007773 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 566546007774 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 566546007775 active site 566546007776 HIGH motif; other site 566546007777 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 566546007778 active site 566546007779 KMSKS motif; other site 566546007780 Transcriptional regulator [Transcription]; Region: LysR; COG0583 566546007781 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546007782 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 566546007783 putative dimerization interface [polypeptide binding]; other site 566546007784 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 566546007785 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 566546007786 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 566546007787 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 566546007788 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 566546007789 nucleotide binding pocket [chemical binding]; other site 566546007790 K-X-D-G motif; other site 566546007791 catalytic site [active] 566546007792 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 566546007793 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 566546007794 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 566546007795 Dimer interface [polypeptide binding]; other site 566546007796 BRCT sequence motif; other site 566546007797 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 566546007798 cell division protein ZipA; Provisional; Region: PRK03427 566546007799 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 566546007800 FtsZ protein binding site [polypeptide binding]; other site 566546007801 putative sulfate transport protein CysZ; Validated; Region: PRK04949 566546007802 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 566546007803 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 566546007804 dimer interface [polypeptide binding]; other site 566546007805 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546007806 catalytic residue [active] 566546007807 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 566546007808 dimerization domain swap beta strand [polypeptide binding]; other site 566546007809 regulatory protein interface [polypeptide binding]; other site 566546007810 active site 566546007811 regulatory phosphorylation site [posttranslational modification]; other site 566546007812 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 566546007813 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 566546007814 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 566546007815 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 566546007816 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 566546007817 HPr interaction site; other site 566546007818 glycerol kinase (GK) interaction site [polypeptide binding]; other site 566546007819 active site 566546007820 phosphorylation site [posttranslational modification] 566546007821 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 566546007822 dimer interface [polypeptide binding]; other site 566546007823 pyridoxamine kinase; Validated; Region: PRK05756 566546007824 pyridoxal binding site [chemical binding]; other site 566546007825 ATP binding site [chemical binding]; other site 566546007826 hypothetical protein; Provisional; Region: PRK10318 566546007827 cysteine synthase B; Region: cysM; TIGR01138 566546007828 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 566546007829 dimer interface [polypeptide binding]; other site 566546007830 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546007831 catalytic residue [active] 566546007832 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 566546007833 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 566546007834 Walker A/P-loop; other site 566546007835 ATP binding site [chemical binding]; other site 566546007836 Q-loop/lid; other site 566546007837 ABC transporter signature motif; other site 566546007838 Walker B; other site 566546007839 D-loop; other site 566546007840 H-loop/switch region; other site 566546007841 TOBE-like domain; Region: TOBE_3; pfam12857 566546007842 sulfate transport protein; Provisional; Region: cysT; CHL00187 566546007843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546007844 dimer interface [polypeptide binding]; other site 566546007845 conserved gate region; other site 566546007846 putative PBP binding loops; other site 566546007847 ABC-ATPase subunit interface; other site 566546007848 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 566546007849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546007850 dimer interface [polypeptide binding]; other site 566546007851 conserved gate region; other site 566546007852 putative PBP binding loops; other site 566546007853 ABC-ATPase subunit interface; other site 566546007854 thiosulfate transporter subunit; Provisional; Region: PRK10852 566546007855 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 566546007856 short chain dehydrogenase; Provisional; Region: PRK08226 566546007857 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 566546007858 NAD binding site [chemical binding]; other site 566546007859 homotetramer interface [polypeptide binding]; other site 566546007860 homodimer interface [polypeptide binding]; other site 566546007861 active site 566546007862 transcriptional regulator MurR; Provisional; Region: PRK15482 566546007863 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 566546007864 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 566546007865 putative active site [active] 566546007866 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 566546007867 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 566546007868 putative active site [active] 566546007869 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 566546007870 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 566546007871 active site turn [active] 566546007872 phosphorylation site [posttranslational modification] 566546007873 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 566546007874 putative periplasmic esterase; Provisional; Region: PRK03642 566546007875 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 566546007876 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 566546007877 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 566546007878 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 566546007879 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 566546007880 putative acetyltransferase; Provisional; Region: PRK03624 566546007881 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 566546007882 Coenzyme A binding pocket [chemical binding]; other site 566546007883 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 566546007884 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 566546007885 active site 566546007886 metal binding site [ion binding]; metal-binding site 566546007887 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 566546007888 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 566546007889 transcriptional regulator EutR; Provisional; Region: PRK10130 566546007890 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546007891 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546007892 carboxysome structural protein EutK; Provisional; Region: PRK15466 566546007893 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 566546007894 Hexamer interface [polypeptide binding]; other site 566546007895 Hexagonal pore residue; other site 566546007896 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 566546007897 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 566546007898 putative hexamer interface [polypeptide binding]; other site 566546007899 putative hexagonal pore; other site 566546007900 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 566546007901 putative hexamer interface [polypeptide binding]; other site 566546007902 putative hexagonal pore; other site 566546007903 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 566546007904 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 566546007905 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 566546007906 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 566546007907 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 566546007908 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 566546007909 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 566546007910 active site 566546007911 metal binding site [ion binding]; metal-binding site 566546007912 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 566546007913 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 566546007914 nucleotide binding site [chemical binding]; other site 566546007915 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 566546007916 putative catalytic cysteine [active] 566546007917 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 566546007918 Hexamer/Pentamer interface [polypeptide binding]; other site 566546007919 central pore; other site 566546007920 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 566546007921 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 566546007922 Hexamer interface [polypeptide binding]; other site 566546007923 Hexagonal pore residue; other site 566546007924 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 566546007925 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 566546007926 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 566546007927 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 566546007928 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 566546007929 G1 box; other site 566546007930 GTP/Mg2+ binding site [chemical binding]; other site 566546007931 G2 box; other site 566546007932 Switch I region; other site 566546007933 G3 box; other site 566546007934 Switch II region; other site 566546007935 G4 box; other site 566546007936 G5 box; other site 566546007937 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 566546007938 putative hexamer interface [polypeptide binding]; other site 566546007939 putative hexagonal pore; other site 566546007940 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 566546007941 Malic enzyme, N-terminal domain; Region: malic; pfam00390 566546007942 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 566546007943 putative NAD(P) binding site [chemical binding]; other site 566546007944 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 566546007945 transaldolase-like protein; Provisional; Region: PTZ00411 566546007946 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 566546007947 active site 566546007948 dimer interface [polypeptide binding]; other site 566546007949 catalytic residue [active] 566546007950 transketolase; Reviewed; Region: PRK12753 566546007951 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 566546007952 TPP-binding site [chemical binding]; other site 566546007953 dimer interface [polypeptide binding]; other site 566546007954 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 566546007955 PYR/PP interface [polypeptide binding]; other site 566546007956 dimer interface [polypeptide binding]; other site 566546007957 TPP binding site [chemical binding]; other site 566546007958 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 566546007959 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 566546007960 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 566546007961 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 566546007962 dimer interface [polypeptide binding]; other site 566546007963 ADP-ribose binding site [chemical binding]; other site 566546007964 active site 566546007965 nudix motif; other site 566546007966 metal binding site [ion binding]; metal-binding site 566546007967 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 566546007968 4Fe-4S binding domain; Region: Fer4; pfam00037 566546007969 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 566546007970 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 566546007971 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 566546007972 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 566546007973 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 566546007974 dimerization interface [polypeptide binding]; other site 566546007975 Histidine kinase; Region: HisKA_3; pfam07730 566546007976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546007977 ATP binding site [chemical binding]; other site 566546007978 Mg2+ binding site [ion binding]; other site 566546007979 G-X-G motif; other site 566546007980 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 566546007981 Protein export membrane protein; Region: SecD_SecF; cl14618 566546007982 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 566546007983 ArsC family; Region: ArsC; pfam03960 566546007984 putative catalytic residues [active] 566546007985 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 566546007986 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 566546007987 metal binding site [ion binding]; metal-binding site 566546007988 dimer interface [polypeptide binding]; other site 566546007989 hypothetical protein; Provisional; Region: PRK13664 566546007990 putative hydrolase; Provisional; Region: PRK11460 566546007991 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 566546007992 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 566546007993 Helicase; Region: Helicase_RecD; pfam05127 566546007994 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 566546007995 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 566546007996 Predicted metalloprotease [General function prediction only]; Region: COG2321 566546007997 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 566546007998 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 566546007999 oligomeric interface; other site 566546008000 putative active site [active] 566546008001 homodimer interface [polypeptide binding]; other site 566546008002 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 566546008003 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 566546008004 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 566546008005 ATP binding site [chemical binding]; other site 566546008006 active site 566546008007 substrate binding site [chemical binding]; other site 566546008008 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 566546008009 lipoprotein; Provisional; Region: PRK11679 566546008010 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 566546008011 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 566546008012 dihydrodipicolinate synthase; Region: dapA; TIGR00674 566546008013 dimer interface [polypeptide binding]; other site 566546008014 active site 566546008015 catalytic residue [active] 566546008016 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 566546008017 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 566546008018 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 566546008019 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 566546008020 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 566546008021 catalytic triad [active] 566546008022 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 566546008023 4Fe-4S binding domain; Region: Fer4; pfam00037 566546008024 hydrogenase 4 subunit B; Validated; Region: PRK06521 566546008025 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 566546008026 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 566546008027 NADH dehydrogenase; Region: NADHdh; cl00469 566546008028 hydrogenase 4 subunit D; Validated; Region: PRK06525 566546008029 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 566546008030 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 566546008031 hydrogenase 4 subunit F; Validated; Region: PRK06458 566546008032 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 566546008033 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 566546008034 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 566546008035 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 566546008036 hydrogenase 4 subunit H; Validated; Region: PRK08222 566546008037 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 566546008038 pseudogene, hydrogenase 4, Fe-S subunit 566546008039 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 566546008040 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 566546008041 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 566546008042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546008043 Walker A motif; other site 566546008044 ATP binding site [chemical binding]; other site 566546008045 Walker B motif; other site 566546008046 arginine finger; other site 566546008047 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 566546008048 putative formate transporter; Provisional; Region: focB; PRK09713 566546008049 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 566546008050 Domain of unknown function DUF20; Region: UPF0118; pfam01594 566546008051 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 566546008052 Peptidase family M48; Region: Peptidase_M48; cl12018 566546008053 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 566546008054 ArsC family; Region: ArsC; pfam03960 566546008055 catalytic residues [active] 566546008056 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 566546008057 DNA replication initiation factor; Provisional; Region: PRK08084 566546008058 uracil transporter; Provisional; Region: PRK10720 566546008059 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 566546008060 active site 566546008061 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 566546008062 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 566546008063 dimerization interface [polypeptide binding]; other site 566546008064 putative ATP binding site [chemical binding]; other site 566546008065 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 566546008066 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 566546008067 active site 566546008068 substrate binding site [chemical binding]; other site 566546008069 cosubstrate binding site; other site 566546008070 catalytic site [active] 566546008071 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 566546008072 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 566546008073 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 566546008074 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 566546008075 domain interface [polypeptide binding]; other site 566546008076 active site 566546008077 catalytic site [active] 566546008078 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 566546008079 putative active site [active] 566546008080 catalytic site [active] 566546008081 exopolyphosphatase; Provisional; Region: PRK10854 566546008082 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 566546008083 MASE1; Region: MASE1; pfam05231 566546008084 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 566546008085 diguanylate cyclase; Region: GGDEF; smart00267 566546008086 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 566546008087 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 566546008088 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 566546008089 GMP synthase; Reviewed; Region: guaA; PRK00074 566546008090 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 566546008091 AMP/PPi binding site [chemical binding]; other site 566546008092 candidate oxyanion hole; other site 566546008093 catalytic triad [active] 566546008094 potential glutamine specificity residues [chemical binding]; other site 566546008095 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 566546008096 ATP Binding subdomain [chemical binding]; other site 566546008097 Ligand Binding sites [chemical binding]; other site 566546008098 Dimerization subdomain; other site 566546008099 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 566546008100 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 566546008101 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 566546008102 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 566546008103 active site 566546008104 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 566546008105 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 566546008106 generic binding surface II; other site 566546008107 generic binding surface I; other site 566546008108 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 566546008109 GTP-binding protein Der; Reviewed; Region: PRK00093 566546008110 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 566546008111 G1 box; other site 566546008112 GTP/Mg2+ binding site [chemical binding]; other site 566546008113 Switch I region; other site 566546008114 G2 box; other site 566546008115 Switch II region; other site 566546008116 G3 box; other site 566546008117 G4 box; other site 566546008118 G5 box; other site 566546008119 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 566546008120 G1 box; other site 566546008121 GTP/Mg2+ binding site [chemical binding]; other site 566546008122 Switch I region; other site 566546008123 G2 box; other site 566546008124 G3 box; other site 566546008125 Switch II region; other site 566546008126 G4 box; other site 566546008127 G5 box; other site 566546008128 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 566546008129 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 566546008130 Trp docking motif [polypeptide binding]; other site 566546008131 active site 566546008132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 566546008133 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 566546008134 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 566546008135 dimer interface [polypeptide binding]; other site 566546008136 motif 1; other site 566546008137 active site 566546008138 motif 2; other site 566546008139 motif 3; other site 566546008140 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 566546008141 anticodon binding site; other site 566546008142 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 566546008143 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 566546008144 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 566546008145 cytoskeletal protein RodZ; Provisional; Region: PRK10856 566546008146 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 566546008147 non-specific DNA binding site [nucleotide binding]; other site 566546008148 salt bridge; other site 566546008149 sequence-specific DNA binding site [nucleotide binding]; other site 566546008150 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 566546008151 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 566546008152 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 566546008153 FeS/SAM binding site; other site 566546008154 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 566546008155 active site 566546008156 multimer interface [polypeptide binding]; other site 566546008157 penicillin-binding protein 1C; Provisional; Region: PRK11240 566546008158 Transglycosylase; Region: Transgly; pfam00912 566546008159 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 566546008160 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 566546008161 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 566546008162 MG2 domain; Region: A2M_N; pfam01835 566546008163 Alpha-2-macroglobulin family; Region: A2M; pfam00207 566546008164 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 566546008165 surface patch; other site 566546008166 thioester region; other site 566546008167 specificity defining residues; other site 566546008168 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 566546008169 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 566546008170 active site residue [active] 566546008171 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 566546008172 active site residue [active] 566546008173 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 566546008174 aminopeptidase B; Provisional; Region: PRK05015 566546008175 Peptidase; Region: DUF3663; pfam12404 566546008176 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 566546008177 interface (dimer of trimers) [polypeptide binding]; other site 566546008178 Substrate-binding/catalytic site; other site 566546008179 Zn-binding sites [ion binding]; other site 566546008180 hypothetical protein; Provisional; Region: PRK10721 566546008181 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 566546008182 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 566546008183 catalytic loop [active] 566546008184 iron binding site [ion binding]; other site 566546008185 chaperone protein HscA; Provisional; Region: hscA; PRK05183 566546008186 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 566546008187 nucleotide binding site [chemical binding]; other site 566546008188 putative NEF/HSP70 interaction site [polypeptide binding]; other site 566546008189 SBD interface [polypeptide binding]; other site 566546008190 co-chaperone HscB; Provisional; Region: hscB; PRK05014 566546008191 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 566546008192 HSP70 interaction site [polypeptide binding]; other site 566546008193 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 566546008194 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 566546008195 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 566546008196 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 566546008197 trimerization site [polypeptide binding]; other site 566546008198 active site 566546008199 cysteine desulfurase; Provisional; Region: PRK14012 566546008200 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 566546008201 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 566546008202 catalytic residue [active] 566546008203 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 566546008204 Rrf2 family protein; Region: rrf2_super; TIGR00738 566546008205 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 566546008206 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 566546008207 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 566546008208 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 566546008209 active site 566546008210 dimerization interface [polypeptide binding]; other site 566546008211 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 566546008212 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 566546008213 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 566546008214 PRD domain; Region: PRD; pfam00874 566546008215 PRD domain; Region: PRD; pfam00874 566546008216 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 566546008217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546008218 putative substrate translocation pore; other site 566546008219 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 566546008220 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546008221 The C-terminal substrate binding domain of LysR-type transcriptional regulator HcaR in involved in 3-phenylpropionic acid catabolism, contains the type2 periplasmic binding fold; Region: PBP2_HcaR; cd08450 566546008222 putative dimerization interface [polypeptide binding]; other site 566546008223 putative substrate binding pocket [chemical binding]; other site 566546008224 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 566546008225 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 566546008226 iron-sulfur cluster [ion binding]; other site 566546008227 [2Fe-2S] cluster binding site [ion binding]; other site 566546008228 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 566546008229 beta subunit interface [polypeptide binding]; other site 566546008230 alpha subunit interface [polypeptide binding]; other site 566546008231 active site 566546008232 substrate binding site [chemical binding]; other site 566546008233 Fe binding site [ion binding]; other site 566546008234 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 566546008235 inter-subunit interface; other site 566546008236 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 566546008237 [2Fe-2S] cluster binding site [ion binding]; other site 566546008238 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 566546008239 cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348 566546008240 NAD binding site [chemical binding]; other site 566546008241 active site 566546008242 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 566546008243 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 566546008244 Predicted membrane protein [Function unknown]; Region: COG2259 566546008245 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 566546008246 active site 566546008247 catalytic residues [active] 566546008248 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 566546008249 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 566546008250 putative NAD(P) binding site [chemical binding]; other site 566546008251 catalytic Zn binding site [ion binding]; other site 566546008252 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 566546008253 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 566546008254 TM-ABC transporter signature motif; other site 566546008255 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 566546008256 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 566546008257 Walker A/P-loop; other site 566546008258 ATP binding site [chemical binding]; other site 566546008259 Q-loop/lid; other site 566546008260 ABC transporter signature motif; other site 566546008261 Walker B; other site 566546008262 D-loop; other site 566546008263 H-loop/switch region; other site 566546008264 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 566546008265 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 566546008266 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 566546008267 ligand binding site [chemical binding]; other site 566546008268 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 566546008269 TPR motif; other site 566546008270 Tetratricopeptide repeat; Region: TPR_16; pfam13432 566546008271 binding surface 566546008272 TPR repeat; Region: TPR_11; pfam13414 566546008273 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 566546008274 TPR motif; other site 566546008275 binding surface 566546008276 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 566546008277 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 566546008278 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 566546008279 nucleotide binding site [chemical binding]; other site 566546008280 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 566546008281 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 566546008282 dimer interface [polypeptide binding]; other site 566546008283 active site 566546008284 glycine-pyridoxal phosphate binding site [chemical binding]; other site 566546008285 folate binding site [chemical binding]; other site 566546008286 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 566546008287 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 566546008288 heme-binding site [chemical binding]; other site 566546008289 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 566546008290 FAD binding pocket [chemical binding]; other site 566546008291 FAD binding motif [chemical binding]; other site 566546008292 phosphate binding motif [ion binding]; other site 566546008293 beta-alpha-beta structure motif; other site 566546008294 NAD binding pocket [chemical binding]; other site 566546008295 Heme binding pocket [chemical binding]; other site 566546008296 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 566546008297 Nitrogen regulatory protein P-II; Region: P-II; smart00938 566546008298 response regulator GlrR; Provisional; Region: PRK15115 566546008299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546008300 active site 566546008301 phosphorylation site [posttranslational modification] 566546008302 intermolecular recognition site; other site 566546008303 dimerization interface [polypeptide binding]; other site 566546008304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546008305 Walker A motif; other site 566546008306 ATP binding site [chemical binding]; other site 566546008307 Walker B motif; other site 566546008308 arginine finger; other site 566546008309 hypothetical protein; Provisional; Region: PRK10722 566546008310 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 566546008311 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 566546008312 dimer interface [polypeptide binding]; other site 566546008313 phosphorylation site [posttranslational modification] 566546008314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546008315 ATP binding site [chemical binding]; other site 566546008316 Mg2+ binding site [ion binding]; other site 566546008317 G-X-G motif; other site 566546008318 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 566546008319 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 566546008320 dimerization interface [polypeptide binding]; other site 566546008321 ATP binding site [chemical binding]; other site 566546008322 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 566546008323 dimerization interface [polypeptide binding]; other site 566546008324 ATP binding site [chemical binding]; other site 566546008325 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 566546008326 putative active site [active] 566546008327 catalytic triad [active] 566546008328 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 566546008329 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 566546008330 substrate binding pocket [chemical binding]; other site 566546008331 membrane-bound complex binding site; other site 566546008332 hinge residues; other site 566546008333 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 566546008334 N-acetyl-D-glucosamine binding site [chemical binding]; other site 566546008335 catalytic residue [active] 566546008336 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 566546008337 nucleoside/Zn binding site; other site 566546008338 dimer interface [polypeptide binding]; other site 566546008339 catalytic motif [active] 566546008340 hypothetical protein; Provisional; Region: PRK11590 566546008341 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 566546008342 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 566546008343 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 566546008344 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 566546008345 putative active site [active] 566546008346 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 566546008347 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 566546008348 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 566546008349 active site 566546008350 hydrophilic channel; other site 566546008351 dimerization interface [polypeptide binding]; other site 566546008352 catalytic residues [active] 566546008353 active site lid [active] 566546008354 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 566546008355 Recombination protein O N terminal; Region: RecO_N; pfam11967 566546008356 Recombination protein O C terminal; Region: RecO_C; pfam02565 566546008357 GTPase Era; Reviewed; Region: era; PRK00089 566546008358 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 566546008359 G1 box; other site 566546008360 GTP/Mg2+ binding site [chemical binding]; other site 566546008361 Switch I region; other site 566546008362 G2 box; other site 566546008363 Switch II region; other site 566546008364 G3 box; other site 566546008365 G4 box; other site 566546008366 G5 box; other site 566546008367 KH domain; Region: KH_2; pfam07650 566546008368 ribonuclease III; Reviewed; Region: rnc; PRK00102 566546008369 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 566546008370 dimerization interface [polypeptide binding]; other site 566546008371 active site 566546008372 metal binding site [ion binding]; metal-binding site 566546008373 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 566546008374 dsRNA binding site [nucleotide binding]; other site 566546008375 signal peptidase I; Provisional; Region: PRK10861 566546008376 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 566546008377 Catalytic site [active] 566546008378 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 566546008379 GTP-binding protein LepA; Provisional; Region: PRK05433 566546008380 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 566546008381 G1 box; other site 566546008382 putative GEF interaction site [polypeptide binding]; other site 566546008383 GTP/Mg2+ binding site [chemical binding]; other site 566546008384 Switch I region; other site 566546008385 G2 box; other site 566546008386 G3 box; other site 566546008387 Switch II region; other site 566546008388 G4 box; other site 566546008389 G5 box; other site 566546008390 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 566546008391 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 566546008392 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 566546008393 SoxR reducing system protein RseC; Provisional; Region: PRK10862 566546008394 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 566546008395 anti-sigma E factor; Provisional; Region: rseB; PRK09455 566546008396 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 566546008397 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 566546008398 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 566546008399 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 566546008400 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 566546008401 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 566546008402 DNA binding residues [nucleotide binding] 566546008403 L-aspartate oxidase; Provisional; Region: PRK09077 566546008404 L-aspartate oxidase; Provisional; Region: PRK06175 566546008405 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 566546008406 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 566546008407 Methyltransferase domain; Region: Methyltransf_26; pfam13659 566546008408 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 566546008409 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 566546008410 ATP binding site [chemical binding]; other site 566546008411 Mg++ binding site [ion binding]; other site 566546008412 motif III; other site 566546008413 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 566546008414 nucleotide binding region [chemical binding]; other site 566546008415 ATP-binding site [chemical binding]; other site 566546008416 Transcriptional regulator [Transcription]; Region: LysR; COG0583 566546008417 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546008418 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 566546008419 dimerization interface [polypeptide binding]; other site 566546008420 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 566546008421 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 566546008422 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 566546008423 ligand binding site [chemical binding]; other site 566546008424 active site 566546008425 UGI interface [polypeptide binding]; other site 566546008426 catalytic site [active] 566546008427 putative methyltransferase; Provisional; Region: PRK10864 566546008428 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 566546008429 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 566546008430 thioredoxin 2; Provisional; Region: PRK10996 566546008431 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 566546008432 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 566546008433 catalytic residues [active] 566546008434 Uncharacterized conserved protein [Function unknown]; Region: COG3148 566546008435 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 566546008436 CoA binding domain; Region: CoA_binding_2; pfam13380 566546008437 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 566546008438 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 566546008439 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 566546008440 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 566546008441 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 566546008442 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 566546008443 domain interface [polypeptide binding]; other site 566546008444 putative active site [active] 566546008445 catalytic site [active] 566546008446 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 566546008447 domain interface [polypeptide binding]; other site 566546008448 putative active site [active] 566546008449 catalytic site [active] 566546008450 lipoprotein; Provisional; Region: PRK10759 566546008451 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 566546008452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546008453 putative substrate translocation pore; other site 566546008454 protein disaggregation chaperone; Provisional; Region: PRK10865 566546008455 Clp amino terminal domain; Region: Clp_N; pfam02861 566546008456 Clp amino terminal domain; Region: Clp_N; pfam02861 566546008457 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546008458 Walker A motif; other site 566546008459 ATP binding site [chemical binding]; other site 566546008460 Walker B motif; other site 566546008461 arginine finger; other site 566546008462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546008463 Walker A motif; other site 566546008464 ATP binding site [chemical binding]; other site 566546008465 Walker B motif; other site 566546008466 arginine finger; other site 566546008467 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 566546008468 hypothetical protein; Provisional; Region: PRK10723 566546008469 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 566546008470 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 566546008471 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 566546008472 RNA binding surface [nucleotide binding]; other site 566546008473 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 566546008474 active site 566546008475 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 566546008476 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 566546008477 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 566546008478 30S subunit binding site; other site 566546008479 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 566546008480 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 566546008481 Prephenate dehydratase; Region: PDT; pfam00800 566546008482 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 566546008483 putative L-Phe binding site [chemical binding]; other site 566546008484 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 566546008485 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 566546008486 prephenate dehydrogenase; Validated; Region: PRK08507 566546008487 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 566546008488 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 566546008489 lipoprotein; Provisional; Region: PRK11443 566546008490 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 566546008491 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 566546008492 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 566546008493 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 566546008494 metal binding site [ion binding]; metal-binding site 566546008495 active site 566546008496 I-site; other site 566546008497 putative outer membrane lipoprotein; Provisional; Region: PRK09967 566546008498 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 566546008499 ligand binding site [chemical binding]; other site 566546008500 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 566546008501 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 566546008502 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 566546008503 RimM N-terminal domain; Region: RimM; pfam01782 566546008504 PRC-barrel domain; Region: PRC; pfam05239 566546008505 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 566546008506 signal recognition particle protein; Provisional; Region: PRK10867 566546008507 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 566546008508 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 566546008509 P loop; other site 566546008510 GTP binding site [chemical binding]; other site 566546008511 Signal peptide binding domain; Region: SRP_SPB; pfam02978 566546008512 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 566546008513 hypothetical protein; Provisional; Region: PRK11573 566546008514 Domain of unknown function DUF21; Region: DUF21; pfam01595 566546008515 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 566546008516 Transporter associated domain; Region: CorC_HlyC; smart01091 566546008517 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 566546008518 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 566546008519 dimer interface [polypeptide binding]; other site 566546008520 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 566546008521 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 566546008522 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 566546008523 recombination and repair protein; Provisional; Region: PRK10869 566546008524 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 566546008525 Walker A/P-loop; other site 566546008526 ATP binding site [chemical binding]; other site 566546008527 Q-loop/lid; other site 566546008528 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 566546008529 Q-loop/lid; other site 566546008530 ABC transporter signature motif; other site 566546008531 Walker B; other site 566546008532 D-loop; other site 566546008533 H-loop/switch region; other site 566546008534 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 566546008535 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 566546008536 hypothetical protein; Validated; Region: PRK01777 566546008537 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 566546008538 putative coenzyme Q binding site [chemical binding]; other site 566546008539 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 566546008540 SmpB-tmRNA interface; other site 566546008541 integrase; Provisional; Region: PRK09692 566546008542 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 566546008543 active site 566546008544 Int/Topo IB signature motif; other site 566546008545 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 566546008546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546008547 ATP binding site [chemical binding]; other site 566546008548 Mg2+ binding site [ion binding]; other site 566546008549 G-X-G motif; other site 566546008550 putative transposase OrfB; Reviewed; Region: PHA02517 566546008551 HTH-like domain; Region: HTH_21; pfam13276 566546008552 Integrase core domain; Region: rve; pfam00665 566546008553 Integrase core domain; Region: rve_2; pfam13333 566546008554 Transposase; Region: HTH_Tnp_1; cl17663 566546008555 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 566546008556 pseudogene, putative alpha-amylase 566546008557 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 566546008558 substrate binding pocket [chemical binding]; other site 566546008559 active site 566546008560 iron coordination sites [ion binding]; other site 566546008561 Predicted dehydrogenase [General function prediction only]; Region: COG0579 566546008562 hydroxyglutarate oxidase; Provisional; Region: PRK11728 566546008563 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 566546008564 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 566546008565 tetramerization interface [polypeptide binding]; other site 566546008566 NAD(P) binding site [chemical binding]; other site 566546008567 catalytic residues [active] 566546008568 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 566546008569 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 566546008570 inhibitor-cofactor binding pocket; inhibition site 566546008571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546008572 catalytic residue [active] 566546008573 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 566546008574 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 566546008575 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 566546008576 DNA-binding site [nucleotide binding]; DNA binding site 566546008577 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 566546008578 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 566546008579 bacterial OsmY and nodulation domain; Region: BON; smart00749 566546008580 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 566546008581 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 566546008582 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 566546008583 dimerization interface [polypeptide binding]; other site 566546008584 putative DNA binding site [nucleotide binding]; other site 566546008585 Transcriptional regulators [Transcription]; Region: MarR; COG1846 566546008586 putative Zn2+ binding site [ion binding]; other site 566546008587 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 566546008588 active site residue [active] 566546008589 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 566546008590 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 566546008591 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 566546008592 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 566546008593 hypothetical protein; Provisional; Region: PRK10556 566546008594 hypothetical protein; Provisional; Region: PRK10132 566546008595 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 566546008596 catalytic residues [active] 566546008597 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 566546008598 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 566546008599 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 566546008600 Class I ribonucleotide reductase; Region: RNR_I; cd01679 566546008601 active site 566546008602 dimer interface [polypeptide binding]; other site 566546008603 catalytic residues [active] 566546008604 effector binding site; other site 566546008605 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 566546008606 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 566546008607 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 566546008608 dimer interface [polypeptide binding]; other site 566546008609 putative radical transfer pathway; other site 566546008610 diiron center [ion binding]; other site 566546008611 tyrosyl radical; other site 566546008612 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 566546008613 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 566546008614 Walker A/P-loop; other site 566546008615 ATP binding site [chemical binding]; other site 566546008616 Q-loop/lid; other site 566546008617 ABC transporter signature motif; other site 566546008618 Walker B; other site 566546008619 D-loop; other site 566546008620 H-loop/switch region; other site 566546008621 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 566546008622 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 566546008623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546008624 dimer interface [polypeptide binding]; other site 566546008625 conserved gate region; other site 566546008626 putative PBP binding loops; other site 566546008627 ABC-ATPase subunit interface; other site 566546008628 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 566546008629 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 566546008630 pseudogene, putative transport protein 566546008631 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 566546008632 putative L-valine exporter; Provisional; Region: PRK10408 566546008633 transcriptional repressor MprA; Provisional; Region: PRK10870 566546008634 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 566546008635 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 566546008636 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 566546008637 HlyD family secretion protein; Region: HlyD_3; pfam13437 566546008638 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 566546008639 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546008640 putative substrate translocation pore; other site 566546008641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546008642 RNA ligase; Region: RNA_ligase; pfam09414 566546008643 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 566546008644 Zn2+ binding site [ion binding]; other site 566546008645 Mg2+ binding site [ion binding]; other site 566546008646 AAA domain; Region: AAA_33; pfam13671 566546008647 S-ribosylhomocysteinase; Provisional; Region: PRK02260 566546008648 glutamate--cysteine ligase; Provisional; Region: PRK02107 566546008649 Predicted membrane protein [Function unknown]; Region: COG1238 566546008650 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 566546008651 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 566546008652 motif II; other site 566546008653 carbon storage regulator; Provisional; Region: PRK01712 566546008654 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 566546008655 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 566546008656 motif 1; other site 566546008657 active site 566546008658 motif 2; other site 566546008659 motif 3; other site 566546008660 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 566546008661 DHHA1 domain; Region: DHHA1; pfam02272 566546008662 recombination regulator RecX; Reviewed; Region: recX; PRK00117 566546008663 recombinase A; Provisional; Region: recA; PRK09354 566546008664 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 566546008665 hexamer interface [polypeptide binding]; other site 566546008666 Walker A motif; other site 566546008667 ATP binding site [chemical binding]; other site 566546008668 Walker B motif; other site 566546008669 hypothetical protein; Validated; Region: PRK03661 566546008670 Transglycosylase SLT domain; Region: SLT_2; pfam13406 566546008671 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 566546008672 N-acetyl-D-glucosamine binding site [chemical binding]; other site 566546008673 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 566546008674 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 566546008675 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 566546008676 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 566546008677 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 566546008678 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 566546008679 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 566546008680 putative NAD(P) binding site [chemical binding]; other site 566546008681 active site 566546008682 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 566546008683 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 566546008684 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 566546008685 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 566546008686 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 566546008687 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 566546008688 putative active site [active] 566546008689 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 566546008690 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 566546008691 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 566546008692 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546008693 Walker A motif; other site 566546008694 ATP binding site [chemical binding]; other site 566546008695 Walker B motif; other site 566546008696 arginine finger; other site 566546008697 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 566546008698 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 566546008699 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 566546008700 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 566546008701 iron binding site [ion binding]; other site 566546008702 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 566546008703 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 566546008704 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 566546008705 Acylphosphatase; Region: Acylphosphatase; pfam00708 566546008706 HypF finger; Region: zf-HYPF; pfam07503 566546008707 HypF finger; Region: zf-HYPF; pfam07503 566546008708 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 566546008709 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 566546008710 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 566546008711 Transcriptional regulators [Transcription]; Region: PurR; COG1609 566546008712 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 566546008713 DNA binding site [nucleotide binding] 566546008714 domain linker motif; other site 566546008715 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 566546008716 dimerization interface (closed form) [polypeptide binding]; other site 566546008717 ligand binding site [chemical binding]; other site 566546008718 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 566546008719 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 566546008720 active site turn [active] 566546008721 phosphorylation site [posttranslational modification] 566546008722 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 566546008723 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 566546008724 beta-galactosidase; Region: BGL; TIGR03356 566546008725 pseudogene, IS621 transposase fragment 566546008726 pseudogene, IS621 transposase fragment 566546008727 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 566546008728 nickel binding site [ion binding]; other site 566546008729 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 566546008730 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 566546008731 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 566546008732 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 566546008733 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 566546008734 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 566546008735 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 566546008736 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 566546008737 NADH dehydrogenase; Region: NADHdh; cl00469 566546008738 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 566546008739 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 566546008740 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 566546008741 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 566546008742 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 566546008743 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 566546008744 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 566546008745 hydrogenase assembly chaperone; Provisional; Region: PRK10409 566546008746 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 566546008747 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 566546008748 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 566546008749 dimerization interface [polypeptide binding]; other site 566546008750 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 566546008751 ATP binding site [chemical binding]; other site 566546008752 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 566546008753 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 566546008754 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 566546008755 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546008756 Walker A motif; other site 566546008757 ATP binding site [chemical binding]; other site 566546008758 Walker B motif; other site 566546008759 arginine finger; other site 566546008760 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 566546008761 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 566546008762 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 566546008763 MutS domain I; Region: MutS_I; pfam01624 566546008764 MutS domain II; Region: MutS_II; pfam05188 566546008765 MutS domain III; Region: MutS_III; pfam05192 566546008766 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 566546008767 Walker A/P-loop; other site 566546008768 ATP binding site [chemical binding]; other site 566546008769 Q-loop/lid; other site 566546008770 ABC transporter signature motif; other site 566546008771 Walker B; other site 566546008772 D-loop; other site 566546008773 H-loop/switch region; other site 566546008774 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 566546008775 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 566546008776 active site 566546008777 metal binding site [ion binding]; metal-binding site 566546008778 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 566546008779 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 566546008780 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 566546008781 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 566546008782 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 566546008783 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 566546008784 putative aldolase; Validated; Region: PRK08130 566546008785 active site 566546008786 intersubunit interface [polypeptide binding]; other site 566546008787 Zn2+ binding site [ion binding]; other site 566546008788 hypothetical protein; Provisional; Region: PRK09989 566546008789 putative transporter; Provisional; Region: PRK09821 566546008790 GntP family permease; Region: GntP_permease; pfam02447 566546008791 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 566546008792 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 566546008793 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 566546008794 Flavoprotein; Region: Flavoprotein; pfam02441 566546008795 MarR family; Region: MarR_2; cl17246 566546008796 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 566546008797 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 566546008798 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 566546008799 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 566546008800 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 566546008801 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 566546008802 DNA binding residues [nucleotide binding] 566546008803 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 566546008804 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 566546008805 Peptidase family M23; Region: Peptidase_M23; pfam01551 566546008806 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 566546008807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546008808 S-adenosylmethionine binding site [chemical binding]; other site 566546008809 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 566546008810 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 566546008811 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 566546008812 Permutation of conserved domain; other site 566546008813 active site 566546008814 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 566546008815 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 566546008816 homotrimer interaction site [polypeptide binding]; other site 566546008817 zinc binding site [ion binding]; other site 566546008818 CDP-binding sites; other site 566546008819 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 566546008820 substrate binding site; other site 566546008821 dimer interface; other site 566546008822 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 566546008823 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 566546008824 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 566546008825 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 566546008826 ligand-binding site [chemical binding]; other site 566546008827 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 566546008828 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 566546008829 CysD dimerization site [polypeptide binding]; other site 566546008830 G1 box; other site 566546008831 putative GEF interaction site [polypeptide binding]; other site 566546008832 GTP/Mg2+ binding site [chemical binding]; other site 566546008833 Switch I region; other site 566546008834 G2 box; other site 566546008835 G3 box; other site 566546008836 Switch II region; other site 566546008837 G4 box; other site 566546008838 G5 box; other site 566546008839 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 566546008840 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 566546008841 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 566546008842 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 566546008843 Active Sites [active] 566546008844 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 566546008845 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 566546008846 metal binding site [ion binding]; metal-binding site 566546008847 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 566546008848 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 566546008849 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09664 566546008850 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 566546008851 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 566546008852 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 566546008853 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cl09719 566546008854 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 566546008855 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 566546008856 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 566546008857 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 566546008858 Hok/gef family; Region: HOK_GEF; pfam01848 566546008859 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 566546008860 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 566546008861 Active Sites [active] 566546008862 sulfite reductase subunit beta; Provisional; Region: PRK13504 566546008863 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 566546008864 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 566546008865 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 566546008866 Flavodoxin; Region: Flavodoxin_1; pfam00258 566546008867 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 566546008868 FAD binding pocket [chemical binding]; other site 566546008869 FAD binding motif [chemical binding]; other site 566546008870 catalytic residues [active] 566546008871 NAD binding pocket [chemical binding]; other site 566546008872 phosphate binding motif [ion binding]; other site 566546008873 beta-alpha-beta structure motif; other site 566546008874 6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470 566546008875 homohexamer interface [polypeptide binding]; other site 566546008876 putative substrate stabilizing pore; other site 566546008877 pterin binding site; other site 566546008878 putative oxidoreductase FixC; Provisional; Region: PRK10157 566546008879 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 566546008880 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 566546008881 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 566546008882 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 566546008883 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 566546008884 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 566546008885 Ligand binding site [chemical binding]; other site 566546008886 Electron transfer flavoprotein domain; Region: ETF; pfam01012 566546008887 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 566546008888 benzoate transport; Region: 2A0115; TIGR00895 566546008889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546008890 putative substrate translocation pore; other site 566546008891 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 566546008892 FAD binding domain; Region: FAD_binding_4; pfam01565 566546008893 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 566546008894 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 566546008895 NADP binding site [chemical binding]; other site 566546008896 homodimer interface [polypeptide binding]; other site 566546008897 active site 566546008898 Major Facilitator Superfamily; Region: MFS_1; pfam07690 566546008899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546008900 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 566546008901 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 566546008902 nucleotide binding site [chemical binding]; other site 566546008903 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 566546008904 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 566546008905 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 566546008906 Repair protein; Region: Repair_PSII; pfam04536 566546008907 enolase; Provisional; Region: eno; PRK00077 566546008908 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 566546008909 dimer interface [polypeptide binding]; other site 566546008910 metal binding site [ion binding]; metal-binding site 566546008911 substrate binding pocket [chemical binding]; other site 566546008912 CTP synthetase; Validated; Region: pyrG; PRK05380 566546008913 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 566546008914 Catalytic site [active] 566546008915 active site 566546008916 UTP binding site [chemical binding]; other site 566546008917 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 566546008918 active site 566546008919 putative oxyanion hole; other site 566546008920 catalytic triad [active] 566546008921 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 566546008922 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 566546008923 homodimer interface [polypeptide binding]; other site 566546008924 metal binding site [ion binding]; metal-binding site 566546008925 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 566546008926 homodimer interface [polypeptide binding]; other site 566546008927 active site 566546008928 putative chemical substrate binding site [chemical binding]; other site 566546008929 metal binding site [ion binding]; metal-binding site 566546008930 toxin MazF; Provisional; Region: PRK09907 566546008931 antitoxin MazE; Provisional; Region: PRK09798 566546008932 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 566546008933 HD domain; Region: HD_4; pfam13328 566546008934 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 566546008935 synthetase active site [active] 566546008936 NTP binding site [chemical binding]; other site 566546008937 metal binding site [ion binding]; metal-binding site 566546008938 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 566546008939 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 566546008940 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 566546008941 TRAM domain; Region: TRAM; pfam01938 566546008942 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546008943 S-adenosylmethionine binding site [chemical binding]; other site 566546008944 pseudogene, hybrid sensory histidine kinase, in two-component regulatory system with UvrY 566546008945 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 566546008946 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 566546008947 active site 566546008948 tetramer interface [polypeptide binding]; other site 566546008949 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 566546008950 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 566546008951 active site 566546008952 tetramer interface [polypeptide binding]; other site 566546008953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546008954 D-galactonate transporter; Region: 2A0114; TIGR00893 566546008955 putative substrate translocation pore; other site 566546008956 flavodoxin; Provisional; Region: PRK08105 566546008957 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 566546008958 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 566546008959 probable active site [active] 566546008960 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 566546008961 SecY interacting protein Syd; Provisional; Region: PRK04968 566546008962 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 566546008963 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 566546008964 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 566546008965 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 566546008966 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 566546008967 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 566546008968 serine transporter; Region: stp; TIGR00814 566546008969 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 566546008970 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 566546008971 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 566546008972 flap endonuclease-like protein; Provisional; Region: PRK09482 566546008973 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 566546008974 active site 566546008975 metal binding site 1 [ion binding]; metal-binding site 566546008976 putative 5' ssDNA interaction site; other site 566546008977 metal binding site 3; metal-binding site 566546008978 metal binding site 2 [ion binding]; metal-binding site 566546008979 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 566546008980 putative DNA binding site [nucleotide binding]; other site 566546008981 putative metal binding site [ion binding]; other site 566546008982 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 566546008983 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 566546008984 dimer interface [polypeptide binding]; other site 566546008985 active site 566546008986 metal binding site [ion binding]; metal-binding site 566546008987 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 566546008988 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 566546008989 intersubunit interface [polypeptide binding]; other site 566546008990 active site 566546008991 Zn2+ binding site [ion binding]; other site 566546008992 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 566546008993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546008994 putative substrate translocation pore; other site 566546008995 L-fucose isomerase; Provisional; Region: fucI; PRK10991 566546008996 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 566546008997 hexamer (dimer of trimers) interface [polypeptide binding]; other site 566546008998 trimer interface [polypeptide binding]; other site 566546008999 substrate binding site [chemical binding]; other site 566546009000 Mn binding site [ion binding]; other site 566546009001 L-fuculokinase; Provisional; Region: PRK10331 566546009002 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 566546009003 nucleotide binding site [chemical binding]; other site 566546009004 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 566546009005 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 566546009006 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 566546009007 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 566546009008 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 566546009009 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 566546009010 hypothetical protein; Provisional; Region: PRK10873 566546009011 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 566546009012 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546009013 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 566546009014 dimerization interface [polypeptide binding]; other site 566546009015 substrate binding pocket [chemical binding]; other site 566546009016 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 566546009017 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 566546009018 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 566546009019 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 566546009020 catalytic residue [active] 566546009021 CsdA-binding activator; Provisional; Region: PRK15019 566546009022 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 566546009023 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 566546009024 putative ATP binding site [chemical binding]; other site 566546009025 putative substrate interface [chemical binding]; other site 566546009026 murein transglycosylase A; Provisional; Region: mltA; PRK11162 566546009027 MltA specific insert domain; Region: MltA; pfam03562 566546009028 3D domain; Region: 3D; pfam06725 566546009029 Protein of unknown function (DUF770); Region: DUF770; pfam05591 566546009030 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 566546009031 Protein of unknown function (DUF877); Region: DUF877; pfam05943 566546009032 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 566546009033 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 566546009034 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 566546009035 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 566546009036 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 566546009037 ligand binding site [chemical binding]; other site 566546009038 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 566546009039 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 566546009040 Clp amino terminal domain; Region: Clp_N; pfam02861 566546009041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546009042 Walker A motif; other site 566546009043 ATP binding site [chemical binding]; other site 566546009044 Walker B motif; other site 566546009045 arginine finger; other site 566546009046 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546009047 Walker A motif; other site 566546009048 ATP binding site [chemical binding]; other site 566546009049 Walker B motif; other site 566546009050 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 566546009051 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 566546009052 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 566546009053 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 566546009054 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 566546009055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 566546009056 pseudogene, type VI secretion system Vgr family protein 566546009057 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 566546009058 N-acetyl-D-glucosamine binding site [chemical binding]; other site 566546009059 catalytic residue [active] 566546009060 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 566546009061 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 566546009062 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 566546009063 pseudogene, type VI secretion-associated protein, fragment 566546009064 PAAR motif; Region: PAAR_motif; pfam05488 566546009065 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 566546009066 PAAR motif; Region: PAAR_motif; pfam05488 566546009067 Integrase core domain; Region: rve; pfam00665 566546009068 DDE domain; Region: DDE_Tnp_IS240; pfam13610 566546009069 Integrase core domain; Region: rve_3; pfam13683 566546009070 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 566546009071 Transposase; Region: HTH_Tnp_1; cl17663 566546009072 FlgD Tudor-like domain; Region: FLgD_tudor; cl17881 566546009073 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 566546009074 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 566546009075 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 566546009076 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 566546009077 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 566546009078 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 566546009079 ImpA domain protein; Region: DUF3702; pfam12486 566546009080 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 566546009081 AMIN domain; Region: AMIN; pfam11741 566546009082 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 566546009083 active site 566546009084 metal binding site [ion binding]; metal-binding site 566546009085 N-acetylglutamate synthase; Validated; Region: PRK05279 566546009086 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 566546009087 putative feedback inhibition sensing region; other site 566546009088 putative nucleotide binding site [chemical binding]; other site 566546009089 putative substrate binding site [chemical binding]; other site 566546009090 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 566546009091 Coenzyme A binding pocket [chemical binding]; other site 566546009092 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 566546009093 AAA domain; Region: AAA_30; pfam13604 566546009094 Family description; Region: UvrD_C_2; pfam13538 566546009095 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 566546009096 protease3; Provisional; Region: PRK15101 566546009097 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 566546009098 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 566546009099 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 566546009100 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 566546009101 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 566546009102 hypothetical protein; Provisional; Region: PRK10332 566546009103 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 566546009104 hypothetical protein; Provisional; Region: PRK11521 566546009105 hypothetical protein; Provisional; Region: PRK10557 566546009106 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 566546009107 hypothetical protein; Provisional; Region: PRK10506 566546009108 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 566546009109 thymidylate synthase; Reviewed; Region: thyA; PRK01827 566546009110 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 566546009111 dimerization interface [polypeptide binding]; other site 566546009112 active site 566546009113 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 566546009114 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 566546009115 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 566546009116 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 566546009117 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 566546009118 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 566546009119 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 566546009120 putative active site [active] 566546009121 Ap4A binding site [chemical binding]; other site 566546009122 nudix motif; other site 566546009123 putative metal binding site [ion binding]; other site 566546009124 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 566546009125 putative DNA-binding cleft [nucleotide binding]; other site 566546009126 putative DNA clevage site; other site 566546009127 molecular lever; other site 566546009128 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 566546009129 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 566546009130 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 566546009131 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 566546009132 active site 566546009133 catalytic tetrad [active] 566546009134 lysophospholipid transporter LplT; Provisional; Region: PRK11195 566546009135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546009136 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 566546009137 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 566546009138 putative acyl-acceptor binding pocket; other site 566546009139 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 566546009140 acyl-activating enzyme (AAE) consensus motif; other site 566546009141 putative AMP binding site [chemical binding]; other site 566546009142 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 566546009143 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 566546009144 DNA binding site [nucleotide binding] 566546009145 domain linker motif; other site 566546009146 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 566546009147 dimerization interface (closed form) [polypeptide binding]; other site 566546009148 ligand binding site [chemical binding]; other site 566546009149 diaminopimelate decarboxylase; Provisional; Region: PRK11165 566546009150 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 566546009151 active site 566546009152 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 566546009153 substrate binding site [chemical binding]; other site 566546009154 catalytic residues [active] 566546009155 dimer interface [polypeptide binding]; other site 566546009156 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 566546009157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546009158 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 566546009159 putative dimerization interface [polypeptide binding]; other site 566546009160 putative racemase; Provisional; Region: PRK10200 566546009161 aspartate racemase; Region: asp_race; TIGR00035 566546009162 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 566546009163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546009164 putative substrate translocation pore; other site 566546009165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546009166 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 566546009167 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 566546009168 NADP binding site [chemical binding]; other site 566546009169 homodimer interface [polypeptide binding]; other site 566546009170 active site 566546009171 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 566546009172 putative acyltransferase; Provisional; Region: PRK05790 566546009173 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 566546009174 dimer interface [polypeptide binding]; other site 566546009175 active site 566546009176 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 566546009177 serine transporter; Region: stp; TIGR00814 566546009178 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 566546009179 DNA binding residues [nucleotide binding] 566546009180 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 566546009181 pseudogene, putative exported protein 566546009182 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 566546009183 pseudogene, conserved hypothetical protein 566546009184 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 566546009185 Tetratricopeptide repeat; Region: TPR_3; pfam07720 566546009186 Tetratricopeptide repeat; Region: TPR_3; pfam07720 566546009187 transcriptional regulator; Provisional; Region: PRK11906 566546009188 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 566546009189 DNA binding site [nucleotide binding] 566546009190 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 566546009191 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 566546009192 N-acetyl-D-glucosamine binding site [chemical binding]; other site 566546009193 catalytic residue [active] 566546009194 pseudogene, truncated putative two-component response regulator 566546009195 pseudogene, putative oxygen-regulated invasion protein 566546009196 pseudogene, putative oxygen-regulated invasion protein 566546009197 pseudogene, type III secretion system protein 566546009198 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 566546009199 pseudogene, type III secretion system needle protein 566546009200 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327; cl12363 566546009201 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 566546009202 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 566546009203 DNA binding residues [nucleotide binding] 566546009204 InvH outer membrane lipoprotein; Region: InvH; pfam04741 566546009205 pseudogene, type III secretion system protein 566546009206 type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401 566546009207 pseudogene, type III secretion system protein 566546009208 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 566546009209 pseudogene, type III secretion system apparatus protein YscQ/HrcQ 566546009210 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 566546009211 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 566546009212 Peptidase family M23; Region: Peptidase_M23; pfam01551 566546009213 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 566546009214 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 566546009215 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 566546009216 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 566546009217 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 566546009218 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 566546009219 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 566546009220 catalytic loop [active] 566546009221 iron binding site [ion binding]; other site 566546009222 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 566546009223 GAF domain; Region: GAF; cl17456 566546009224 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 566546009225 PAS domain; Region: PAS; smart00091 566546009226 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546009227 Walker A motif; other site 566546009228 ATP binding site [chemical binding]; other site 566546009229 Walker B motif; other site 566546009230 arginine finger; other site 566546009231 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 566546009232 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 566546009233 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 566546009234 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 566546009235 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 566546009236 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 566546009237 catalytic residue [active] 566546009238 peptidase; Reviewed; Region: PRK13004 566546009239 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 566546009240 putative metal binding site [ion binding]; other site 566546009241 putative dimer interface [polypeptide binding]; other site 566546009242 D-hydantoinase; Region: D-hydantoinase; TIGR02033 566546009243 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 566546009244 tetramer interface [polypeptide binding]; other site 566546009245 active site 566546009246 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 566546009247 carbamate kinase; Reviewed; Region: PRK12686 566546009248 putative substrate binding site [chemical binding]; other site 566546009249 homodimer interface [polypeptide binding]; other site 566546009250 nucleotide binding site [chemical binding]; other site 566546009251 nucleotide binding site [chemical binding]; other site 566546009252 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 566546009253 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 566546009254 XdhC Rossmann domain; Region: XdhC_C; pfam13478 566546009255 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 566546009256 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 566546009257 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 566546009258 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 566546009259 Ligand binding site; other site 566546009260 metal-binding site 566546009261 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 566546009262 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 566546009263 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 566546009264 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 566546009265 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 566546009266 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 566546009267 active site 566546009268 putative substrate binding pocket [chemical binding]; other site 566546009269 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 566546009270 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 566546009271 putative hypoxanthine oxidase; Provisional; Region: PRK09800 566546009272 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 566546009273 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 566546009274 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 566546009275 uracil-xanthine permease; Region: ncs2; TIGR00801 566546009276 guanine deaminase; Provisional; Region: PRK09228 566546009277 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 566546009278 active site 566546009279 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 566546009280 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 566546009281 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 566546009282 4Fe-4S binding domain; Region: Fer4; pfam00037 566546009283 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 566546009284 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 566546009285 xanthine permease; Region: pbuX; TIGR03173 566546009286 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 566546009287 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 566546009288 active site 566546009289 metal binding site [ion binding]; metal-binding site 566546009290 nudix motif; other site 566546009291 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 566546009292 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 566546009293 dimer interface [polypeptide binding]; other site 566546009294 putative anticodon binding site; other site 566546009295 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 566546009296 motif 1; other site 566546009297 active site 566546009298 motif 2; other site 566546009299 motif 3; other site 566546009300 peptide chain release factor 2; Provisional; Region: PRK08787 566546009301 This domain is found in peptide chain release factors; Region: PCRF; smart00937 566546009302 RF-1 domain; Region: RF-1; pfam00472 566546009303 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 566546009304 DHH family; Region: DHH; pfam01368 566546009305 DHHA1 domain; Region: DHHA1; pfam02272 566546009306 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 566546009307 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 566546009308 dimerization domain [polypeptide binding]; other site 566546009309 dimer interface [polypeptide binding]; other site 566546009310 catalytic residues [active] 566546009311 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 566546009312 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 566546009313 active site 566546009314 Int/Topo IB signature motif; other site 566546009315 flavodoxin FldB; Provisional; Region: PRK12359 566546009316 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 566546009317 hypothetical protein; Provisional; Region: PRK10878 566546009318 putative global regulator; Reviewed; Region: PRK09559 566546009319 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 566546009320 hemolysin; Provisional; Region: PRK15087 566546009321 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 566546009322 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 566546009323 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 566546009324 beta-galactosidase; Region: BGL; TIGR03356 566546009325 classical (c) SDRs; Region: SDR_c; cd05233 566546009326 NAD(P) binding site [chemical binding]; other site 566546009327 active site 566546009328 glycine dehydrogenase; Provisional; Region: PRK05367 566546009329 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 566546009330 tetramer interface [polypeptide binding]; other site 566546009331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546009332 catalytic residue [active] 566546009333 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 566546009334 tetramer interface [polypeptide binding]; other site 566546009335 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546009336 catalytic residue [active] 566546009337 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 566546009338 lipoyl attachment site [posttranslational modification]; other site 566546009339 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 566546009340 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 566546009341 oxidoreductase; Provisional; Region: PRK08013 566546009342 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 566546009343 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 566546009344 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 566546009345 proline aminopeptidase P II; Provisional; Region: PRK10879 566546009346 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 566546009347 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 566546009348 active site 566546009349 hypothetical protein; Reviewed; Region: PRK01736 566546009350 Z-ring-associated protein; Provisional; Region: PRK10972 566546009351 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 566546009352 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 566546009353 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 566546009354 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 566546009355 ligand binding site [chemical binding]; other site 566546009356 NAD binding site [chemical binding]; other site 566546009357 tetramer interface [polypeptide binding]; other site 566546009358 catalytic site [active] 566546009359 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 566546009360 L-serine binding site [chemical binding]; other site 566546009361 ACT domain interface; other site 566546009362 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 566546009363 tetramer (dimer of dimers) interface [polypeptide binding]; other site 566546009364 active site 566546009365 dimer interface [polypeptide binding]; other site 566546009366 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 566546009367 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 566546009368 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546009369 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 566546009370 putative dimerization interface [polypeptide binding]; other site 566546009371 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 566546009372 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 566546009373 active site 566546009374 substrate binding site [chemical binding]; other site 566546009375 coenzyme B12 binding site [chemical binding]; other site 566546009376 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 566546009377 B12 binding site [chemical binding]; other site 566546009378 cobalt ligand [ion binding]; other site 566546009379 membrane ATPase/protein kinase; Provisional; Region: PRK09435 566546009380 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 566546009381 Walker A; other site 566546009382 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 566546009383 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 566546009384 substrate binding site [chemical binding]; other site 566546009385 oxyanion hole (OAH) forming residues; other site 566546009386 trimer interface [polypeptide binding]; other site 566546009387 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 566546009388 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 566546009389 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 566546009390 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546009391 Transcriptional regulator [Transcription]; Region: LysR; COG0583 566546009392 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 566546009393 dimerization interface [polypeptide binding]; other site 566546009394 Uncharacterized conserved protein [Function unknown]; Region: COG2968 566546009395 oxidative stress defense protein; Provisional; Region: PRK11087 566546009396 arginine exporter protein; Provisional; Region: PRK09304 566546009397 mechanosensitive channel MscS; Provisional; Region: PRK10334 566546009398 Mechanosensitive ion channel; Region: MS_channel; pfam00924 566546009399 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 566546009400 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 566546009401 active site 566546009402 intersubunit interface [polypeptide binding]; other site 566546009403 zinc binding site [ion binding]; other site 566546009404 Na+ binding site [ion binding]; other site 566546009405 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 566546009406 Phosphoglycerate kinase; Region: PGK; pfam00162 566546009407 substrate binding site [chemical binding]; other site 566546009408 hinge regions; other site 566546009409 ADP binding site [chemical binding]; other site 566546009410 catalytic site [active] 566546009411 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 566546009412 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 566546009413 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 566546009414 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 566546009415 trimer interface [polypeptide binding]; other site 566546009416 putative Zn binding site [ion binding]; other site 566546009417 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 566546009418 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 566546009419 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 566546009420 Walker A/P-loop; other site 566546009421 ATP binding site [chemical binding]; other site 566546009422 Q-loop/lid; other site 566546009423 ABC transporter signature motif; other site 566546009424 Walker B; other site 566546009425 D-loop; other site 566546009426 H-loop/switch region; other site 566546009427 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 566546009428 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 566546009429 Walker A/P-loop; other site 566546009430 ATP binding site [chemical binding]; other site 566546009431 Q-loop/lid; other site 566546009432 ABC transporter signature motif; other site 566546009433 Walker B; other site 566546009434 D-loop; other site 566546009435 H-loop/switch region; other site 566546009436 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 566546009437 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 566546009438 active site 566546009439 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 566546009440 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 566546009441 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 566546009442 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 566546009443 putative active site [active] 566546009444 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 566546009445 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 566546009446 putative NAD(P) binding site [chemical binding]; other site 566546009447 catalytic Zn binding site [ion binding]; other site 566546009448 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 566546009449 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 566546009450 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 566546009451 active site 566546009452 P-loop; other site 566546009453 phosphorylation site [posttranslational modification] 566546009454 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 566546009455 active site 566546009456 phosphorylation site [posttranslational modification] 566546009457 transketolase; Reviewed; Region: PRK12753 566546009458 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 566546009459 TPP-binding site [chemical binding]; other site 566546009460 dimer interface [polypeptide binding]; other site 566546009461 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 566546009462 PYR/PP interface [polypeptide binding]; other site 566546009463 dimer interface [polypeptide binding]; other site 566546009464 TPP binding site [chemical binding]; other site 566546009465 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 566546009466 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 566546009467 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 566546009468 agmatinase; Region: agmatinase; TIGR01230 566546009469 oligomer interface [polypeptide binding]; other site 566546009470 putative active site [active] 566546009471 Mn binding site [ion binding]; other site 566546009472 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 566546009473 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 566546009474 dimer interface [polypeptide binding]; other site 566546009475 active site 566546009476 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 566546009477 catalytic residues [active] 566546009478 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 566546009479 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 566546009480 S-adenosylmethionine synthetase; Validated; Region: PRK05250 566546009481 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 566546009482 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 566546009483 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 566546009484 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 566546009485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546009486 putative substrate translocation pore; other site 566546009487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546009488 hypothetical protein; Provisional; Region: PRK04860 566546009489 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 566546009490 DNA-specific endonuclease I; Provisional; Region: PRK15137 566546009491 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 566546009492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 566546009493 RNA methyltransferase, RsmE family; Region: TIGR00046 566546009494 glutathione synthetase; Provisional; Region: PRK05246 566546009495 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 566546009496 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 566546009497 hypothetical protein; Validated; Region: PRK00228 566546009498 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 566546009499 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 566546009500 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 566546009501 Walker A motif; other site 566546009502 ATP binding site [chemical binding]; other site 566546009503 Walker B motif; other site 566546009504 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 566546009505 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 566546009506 catalytic residue [active] 566546009507 YGGT family; Region: YGGT; pfam02325 566546009508 YGGT family; Region: YGGT; pfam02325 566546009509 hypothetical protein; Validated; Region: PRK05090 566546009510 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 566546009511 active site 566546009512 dimerization interface [polypeptide binding]; other site 566546009513 HemN family oxidoreductase; Provisional; Region: PRK05660 566546009514 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 566546009515 FeS/SAM binding site; other site 566546009516 HemN C-terminal domain; Region: HemN_C; pfam06969 566546009517 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 566546009518 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 566546009519 homodimer interface [polypeptide binding]; other site 566546009520 active site 566546009521 hypothetical protein; Provisional; Region: PRK10626 566546009522 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 566546009523 hypothetical protein; Provisional; Region: PRK11702 566546009524 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 566546009525 adenine DNA glycosylase; Provisional; Region: PRK10880 566546009526 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 566546009527 minor groove reading motif; other site 566546009528 helix-hairpin-helix signature motif; other site 566546009529 substrate binding pocket [chemical binding]; other site 566546009530 active site 566546009531 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 566546009532 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 566546009533 DNA binding and oxoG recognition site [nucleotide binding] 566546009534 oxidative damage protection protein; Provisional; Region: PRK05408 566546009535 murein transglycosylase C; Provisional; Region: mltC; PRK11671 566546009536 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 566546009537 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 566546009538 N-acetyl-D-glucosamine binding site [chemical binding]; other site 566546009539 catalytic residue [active] 566546009540 nucleoside transporter; Region: 2A0110; TIGR00889 566546009541 ornithine decarboxylase; Provisional; Region: PRK13578 566546009542 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 566546009543 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 566546009544 homodimer interface [polypeptide binding]; other site 566546009545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546009546 catalytic residue [active] 566546009547 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 566546009548 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 566546009549 putative general secretion pathway protein YghD; Provisional; Region: PRK09731 566546009550 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 566546009551 GspL-like protein; Provisional; Region: PRK09662 566546009552 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 566546009553 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 566546009554 type II secretion system protein J; Region: gspJ; TIGR01711 566546009555 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 566546009556 type II secretion system protein I; Region: gspI; TIGR01707 566546009557 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 566546009558 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 566546009559 Type II transport protein GspH; Region: GspH; pfam12019 566546009560 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 566546009561 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 566546009562 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 566546009563 type II secretion system protein F; Region: GspF; TIGR02120 566546009564 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 566546009565 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 566546009566 type II secretion system protein E; Region: type_II_gspE; TIGR02533 566546009567 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 566546009568 Walker A motif; other site 566546009569 ATP binding site [chemical binding]; other site 566546009570 Walker B motif; other site 566546009571 type II secretion system protein D; Region: type_II_gspD; TIGR02517 566546009572 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 566546009573 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 566546009574 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 566546009575 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 566546009576 putative type II secretion protein GspC; Provisional; Region: PRK09681 566546009577 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 566546009578 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 566546009579 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 566546009580 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 566546009581 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 566546009582 Domain of unknown function (DUF4092); Region: DUF4092; pfam13322 566546009583 Peptidase M60-like family; Region: M60-like; pfam13402 566546009584 glycolate transporter; Provisional; Region: PRK09695 566546009585 L-lactate permease; Region: Lactate_perm; cl00701 566546009586 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 566546009587 active site 566546009588 hypothetical protein; Provisional; Region: PRK09732 566546009589 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 566546009590 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 566546009591 Cysteine-rich domain; Region: CCG; pfam02754 566546009592 Cysteine-rich domain; Region: CCG; pfam02754 566546009593 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 566546009594 FAD binding domain; Region: FAD_binding_4; pfam01565 566546009595 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 566546009596 FAD binding domain; Region: FAD_binding_4; pfam01565 566546009597 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 566546009598 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 566546009599 DNA-binding site [nucleotide binding]; DNA binding site 566546009600 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 566546009601 pseudogene, conserved hypothetical protein 566546009602 acyl-CoA synthetase; Validated; Region: PRK09192 566546009603 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 566546009604 acyl-activating enzyme (AAE) consensus motif; other site 566546009605 active site 566546009606 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 566546009607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 566546009608 NAD(P) binding site [chemical binding]; other site 566546009609 active site 566546009610 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 566546009611 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 566546009612 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 566546009613 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 566546009614 catalytic residue [active] 566546009615 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 566546009616 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 566546009617 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 566546009618 Predicted permeases [General function prediction only]; Region: COG0795 566546009619 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 566546009620 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 566546009621 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 566546009622 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 566546009623 Thymidylate kinase; Region: Thymidylate_kin; pfam02223 566546009624 active site 566546009625 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 566546009626 thymidylate kinase; Validated; Region: tmk; PRK00698 566546009627 TMP-binding site; other site 566546009628 ATP-binding site [chemical binding]; other site 566546009629 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 566546009630 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 566546009631 TMP-binding site; other site 566546009632 ATP-binding site [chemical binding]; other site 566546009633 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 566546009634 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 566546009635 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 566546009636 CHAP domain; Region: CHAP; pfam05257 566546009637 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 566546009638 putative S-transferase; Provisional; Region: PRK11752 566546009639 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 566546009640 C-terminal domain interface [polypeptide binding]; other site 566546009641 GSH binding site (G-site) [chemical binding]; other site 566546009642 dimer interface [polypeptide binding]; other site 566546009643 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 566546009644 dimer interface [polypeptide binding]; other site 566546009645 N-terminal domain interface [polypeptide binding]; other site 566546009646 active site 566546009647 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 566546009648 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 566546009649 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 566546009650 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 566546009651 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 566546009652 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 566546009653 putative substrate-binding site; other site 566546009654 nickel binding site [ion binding]; other site 566546009655 hydrogenase 2 large subunit; Provisional; Region: PRK10467 566546009656 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 566546009657 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 566546009658 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 566546009659 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 566546009660 4Fe-4S binding domain; Region: Fer4_6; pfam12837 566546009661 hydrogenase 2 small subunit; Provisional; Region: PRK10468 566546009662 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 566546009663 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 566546009664 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 566546009665 pseudogene, dienelactone hydrolase family protein 566546009666 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 566546009667 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 566546009668 active site 566546009669 catalytic tetrad [active] 566546009670 hypothetical protein; Provisional; Region: PRK05208 566546009671 oxidoreductase; Provisional; Region: PRK07985 566546009672 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 566546009673 NAD binding site [chemical binding]; other site 566546009674 metal binding site [ion binding]; metal-binding site 566546009675 active site 566546009676 biopolymer transport protein ExbD; Provisional; Region: PRK11267 566546009677 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 566546009678 biopolymer transport protein ExbB; Provisional; Region: PRK10414 566546009679 cystathionine beta-lyase; Provisional; Region: PRK08114 566546009680 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 566546009681 homodimer interface [polypeptide binding]; other site 566546009682 substrate-cofactor binding pocket; other site 566546009683 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546009684 catalytic residue [active] 566546009685 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 566546009686 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 566546009687 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 566546009688 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 566546009689 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546009690 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546009691 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 566546009692 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 566546009693 dimer interface [polypeptide binding]; other site 566546009694 active site 566546009695 metal binding site [ion binding]; metal-binding site 566546009696 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 566546009697 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 566546009698 active site 566546009699 catalytic tetrad [active] 566546009700 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 566546009701 putative outer membrane lipoprotein; Provisional; Region: PRK09973 566546009702 hypothetical protein; Provisional; Region: PRK01254 566546009703 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 566546009704 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 566546009705 FtsI repressor; Provisional; Region: PRK10883 566546009706 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 566546009707 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 566546009708 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 566546009709 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 566546009710 putative acyl-acceptor binding pocket; other site 566546009711 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 566546009712 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 566546009713 CAP-like domain; other site 566546009714 active site 566546009715 primary dimer interface [polypeptide binding]; other site 566546009716 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 566546009717 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 566546009718 TIGR00156 family protein; Region: TIGR00156 566546009719 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 566546009720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546009721 active site 566546009722 phosphorylation site [posttranslational modification] 566546009723 intermolecular recognition site; other site 566546009724 dimerization interface [polypeptide binding]; other site 566546009725 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 566546009726 DNA binding site [nucleotide binding] 566546009727 sensor protein QseC; Provisional; Region: PRK10337 566546009728 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 566546009729 dimer interface [polypeptide binding]; other site 566546009730 phosphorylation site [posttranslational modification] 566546009731 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546009732 ATP binding site [chemical binding]; other site 566546009733 Mg2+ binding site [ion binding]; other site 566546009734 G-X-G motif; other site 566546009735 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 566546009736 Uncharacterized conserved protein [Function unknown]; Region: COG1359 566546009737 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 566546009738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546009739 ATP binding site [chemical binding]; other site 566546009740 Mg2+ binding site [ion binding]; other site 566546009741 G-X-G motif; other site 566546009742 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 566546009743 anchoring element; other site 566546009744 dimer interface [polypeptide binding]; other site 566546009745 ATP binding site [chemical binding]; other site 566546009746 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 566546009747 active site 566546009748 metal binding site [ion binding]; metal-binding site 566546009749 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 566546009750 esterase YqiA; Provisional; Region: PRK11071 566546009751 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 566546009752 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 566546009753 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 566546009754 active site 566546009755 metal binding site [ion binding]; metal-binding site 566546009756 hexamer interface [polypeptide binding]; other site 566546009757 putative dehydrogenase; Provisional; Region: PRK11039 566546009758 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 566546009759 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 566546009760 dimer interface [polypeptide binding]; other site 566546009761 ADP-ribose binding site [chemical binding]; other site 566546009762 active site 566546009763 nudix motif; other site 566546009764 metal binding site [ion binding]; metal-binding site 566546009765 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 566546009766 hypothetical protein; Provisional; Region: PRK11653 566546009767 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 566546009768 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 566546009769 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 566546009770 putative active site [active] 566546009771 metal binding site [ion binding]; metal-binding site 566546009772 zinc transporter ZupT; Provisional; Region: PRK04201 566546009773 ZIP Zinc transporter; Region: Zip; pfam02535 566546009774 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 566546009775 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 566546009776 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 566546009777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 566546009778 putative fimbrial protein; Provisional; Region: PRK09733 566546009779 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 566546009780 PapC N-terminal domain; Region: PapC_N; pfam13954 566546009781 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 566546009782 PapC C-terminal domain; Region: PapC_C; pfam13953 566546009783 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 566546009784 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 566546009785 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 566546009786 Fimbrial protein; Region: Fimbrial; pfam00419 566546009787 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 566546009788 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 566546009789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 566546009790 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 566546009791 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 566546009792 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 566546009793 putative ribose interaction site [chemical binding]; other site 566546009794 putative ADP binding site [chemical binding]; other site 566546009795 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 566546009796 active site 566546009797 nucleotide binding site [chemical binding]; other site 566546009798 HIGH motif; other site 566546009799 KMSKS motif; other site 566546009800 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 566546009801 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 566546009802 metal binding triad; other site 566546009803 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 566546009804 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 566546009805 metal binding triad; other site 566546009806 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 566546009807 Uncharacterized conserved protein [Function unknown]; Region: COG3025 566546009808 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 566546009809 putative active site [active] 566546009810 putative metal binding residues [ion binding]; other site 566546009811 signature motif; other site 566546009812 putative triphosphate binding site [ion binding]; other site 566546009813 CHAD domain; Region: CHAD; pfam05235 566546009814 SH3 domain-containing protein; Provisional; Region: PRK10884 566546009815 Bacterial SH3 domain homologues; Region: SH3b; smart00287 566546009816 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 566546009817 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 566546009818 active site 566546009819 NTP binding site [chemical binding]; other site 566546009820 metal binding triad [ion binding]; metal-binding site 566546009821 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 566546009822 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 566546009823 Zn2+ binding site [ion binding]; other site 566546009824 Mg2+ binding site [ion binding]; other site 566546009825 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 566546009826 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 566546009827 homooctamer interface [polypeptide binding]; other site 566546009828 active site 566546009829 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 566546009830 transcriptional activator TtdR; Provisional; Region: PRK09801 566546009831 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546009832 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 566546009833 putative effector binding pocket; other site 566546009834 putative dimerization interface [polypeptide binding]; other site 566546009835 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 566546009836 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 566546009837 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 566546009838 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 566546009839 transmembrane helices; other site 566546009840 UGMP family protein; Validated; Region: PRK09604 566546009841 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 566546009842 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 566546009843 DNA primase; Validated; Region: dnaG; PRK05667 566546009844 CHC2 zinc finger; Region: zf-CHC2; pfam01807 566546009845 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 566546009846 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 566546009847 active site 566546009848 metal binding site [ion binding]; metal-binding site 566546009849 interdomain interaction site; other site 566546009850 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 566546009851 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 566546009852 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 566546009853 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 566546009854 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 566546009855 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 566546009856 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 566546009857 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 566546009858 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 566546009859 DNA binding residues [nucleotide binding] 566546009860 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 566546009861 active site 566546009862 SUMO-1 interface [polypeptide binding]; other site 566546009863 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 566546009864 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 566546009865 FAD binding pocket [chemical binding]; other site 566546009866 FAD binding motif [chemical binding]; other site 566546009867 phosphate binding motif [ion binding]; other site 566546009868 NAD binding pocket [chemical binding]; other site 566546009869 Predicted transcriptional regulators [Transcription]; Region: COG1695 566546009870 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 566546009871 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 566546009872 PAS fold; Region: PAS_3; pfam08447 566546009873 putative active site [active] 566546009874 heme pocket [chemical binding]; other site 566546009875 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 566546009876 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 566546009877 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 566546009878 dimer interface [polypeptide binding]; other site 566546009879 putative CheW interface [polypeptide binding]; other site 566546009880 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 566546009881 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 566546009882 inhibitor-cofactor binding pocket; inhibition site 566546009883 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546009884 catalytic residue [active] 566546009885 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 566546009886 dimer interface [polypeptide binding]; other site 566546009887 putative tRNA-binding site [nucleotide binding]; other site 566546009888 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 566546009889 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 566546009890 DNA binding site [nucleotide binding] 566546009891 domain linker motif; other site 566546009892 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 566546009893 putative dimerization interface [polypeptide binding]; other site 566546009894 putative ligand binding site [chemical binding]; other site 566546009895 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 566546009896 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 566546009897 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 566546009898 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 566546009899 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 566546009900 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 566546009901 inner membrane transporter YjeM; Provisional; Region: PRK15238 566546009902 alpha-glucosidase; Provisional; Region: PRK10137 566546009903 Protein of unknown function, DUF608; Region: DUF608; pfam04685 566546009904 Trehalase; Region: Trehalase; cl17346 566546009905 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 566546009906 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 566546009907 active site 566546009908 FMN binding site [chemical binding]; other site 566546009909 2,4-decadienoyl-CoA binding site; other site 566546009910 catalytic residue [active] 566546009911 4Fe-4S cluster binding site [ion binding]; other site 566546009912 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 566546009913 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 566546009914 non-specific DNA binding site [nucleotide binding]; other site 566546009915 salt bridge; other site 566546009916 sequence-specific DNA binding site [nucleotide binding]; other site 566546009917 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 566546009918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546009919 S-adenosylmethionine binding site [chemical binding]; other site 566546009920 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 566546009921 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 566546009922 putative active site [active] 566546009923 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 566546009924 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 566546009925 yybP-ykoY; ECW_nc3354 566546009926 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 566546009927 serine/threonine transporter SstT; Provisional; Region: PRK13628 566546009928 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 566546009929 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 566546009930 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 566546009931 galactarate dehydratase; Region: galactar-dH20; TIGR03248 566546009932 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 566546009933 Glucuronate isomerase; Region: UxaC; pfam02614 566546009934 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 566546009935 D-galactonate transporter; Region: 2A0114; TIGR00893 566546009936 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546009937 putative substrate translocation pore; other site 566546009938 CblD like pilus biogenesis initiator; Region: CblD; cl06460 566546009939 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 566546009940 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 566546009941 CS1 type fimbrial major subunit; Region: Fimbrial_CS1; pfam04449 566546009942 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 566546009943 putative fimbrial protein TcfA; Provisional; Region: PRK15308 566546009944 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 566546009945 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 566546009946 DNA-binding site [nucleotide binding]; DNA binding site 566546009947 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 566546009948 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 566546009949 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 566546009950 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 566546009951 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 566546009952 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 566546009953 Predicted membrane protein [Function unknown]; Region: COG5393 566546009954 YqjK-like protein; Region: YqjK; pfam13997 566546009955 Predicted membrane protein [Function unknown]; Region: COG2259 566546009956 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 566546009957 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 566546009958 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 566546009959 putative dimer interface [polypeptide binding]; other site 566546009960 N-terminal domain interface [polypeptide binding]; other site 566546009961 putative substrate binding pocket (H-site) [chemical binding]; other site 566546009962 Predicted membrane protein [Function unknown]; Region: COG3152 566546009963 Protein of unknown function (DUF805); Region: DUF805; pfam05656 566546009964 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546009965 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 566546009966 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 566546009967 dimerization interface [polypeptide binding]; other site 566546009968 Pirin-related protein [General function prediction only]; Region: COG1741 566546009969 Pirin; Region: Pirin; pfam02678 566546009970 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 566546009971 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 566546009972 serine transporter; Region: stp; TIGR00814 566546009973 L-serine dehydratase TdcG; Provisional; Region: PRK15040 566546009974 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 566546009975 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 566546009976 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 566546009977 homotrimer interaction site [polypeptide binding]; other site 566546009978 putative active site [active] 566546009979 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 566546009980 Pyruvate formate lyase 1; Region: PFL1; cd01678 566546009981 coenzyme A binding site [chemical binding]; other site 566546009982 active site 566546009983 catalytic residues [active] 566546009984 glycine loop; other site 566546009985 propionate/acetate kinase; Provisional; Region: PRK12379 566546009986 Acetokinase family; Region: Acetate_kinase; cl17229 566546009987 threonine/serine transporter TdcC; Provisional; Region: PRK13629 566546009988 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 566546009989 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 566546009990 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 566546009991 tetramer interface [polypeptide binding]; other site 566546009992 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546009993 catalytic residue [active] 566546009994 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 566546009995 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546009996 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 566546009997 putative substrate binding pocket [chemical binding]; other site 566546009998 putative dimerization interface [polypeptide binding]; other site 566546009999 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 566546010000 hypothetical protein; Provisional; Region: PRK09716 566546010001 glycerate kinase I; Provisional; Region: PRK10342 566546010002 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 566546010003 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 566546010004 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 566546010005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546010006 D-galactonate transporter; Region: 2A0114; TIGR00893 566546010007 putative substrate translocation pore; other site 566546010008 galactarate dehydratase; Region: galactar-dH20; TIGR03248 566546010009 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 566546010010 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 566546010011 putative regulator PrlF; Provisional; Region: PRK09974 566546010012 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 566546010013 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 566546010014 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 566546010015 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 566546010016 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 566546010017 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 566546010018 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 566546010019 active site 566546010020 phosphorylation site [posttranslational modification] 566546010021 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 566546010022 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 566546010023 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 566546010024 active pocket/dimerization site; other site 566546010025 active site 566546010026 phosphorylation site [posttranslational modification] 566546010027 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 566546010028 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 566546010029 active site 566546010030 dimer interface [polypeptide binding]; other site 566546010031 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 566546010032 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 566546010033 dimer interface [polypeptide binding]; other site 566546010034 active site 566546010035 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 566546010036 putative active site [active] 566546010037 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453 566546010038 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 566546010039 active site 566546010040 intersubunit interface [polypeptide binding]; other site 566546010041 zinc binding site [ion binding]; other site 566546010042 Na+ binding site [ion binding]; other site 566546010043 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 566546010044 active site 566546010045 phosphorylation site [posttranslational modification] 566546010046 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 566546010047 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 566546010048 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 566546010049 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 566546010050 active site 566546010051 trimer interface [polypeptide binding]; other site 566546010052 allosteric site; other site 566546010053 active site lid [active] 566546010054 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 566546010055 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 566546010056 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 566546010057 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 566546010058 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 566546010059 PapC N-terminal domain; Region: PapC_N; pfam13954 566546010060 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 566546010061 PapC C-terminal domain; Region: PapC_C; pfam13953 566546010062 Fimbrial protein; Region: Fimbrial; pfam00419 566546010063 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 566546010064 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 566546010065 putative SAM binding site [chemical binding]; other site 566546010066 putative homodimer interface [polypeptide binding]; other site 566546010067 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 566546010068 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 566546010069 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 566546010070 putative ligand binding site [chemical binding]; other site 566546010071 TIGR00252 family protein; Region: TIGR00252 566546010072 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 566546010073 dimer interface [polypeptide binding]; other site 566546010074 active site 566546010075 outer membrane lipoprotein; Provisional; Region: PRK11023 566546010076 BON domain; Region: BON; pfam04972 566546010077 BON domain; Region: BON; pfam04972 566546010078 Predicted permease; Region: DUF318; pfam03773 566546010079 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 566546010080 NADH(P)-binding; Region: NAD_binding_10; pfam13460 566546010081 NAD binding site [chemical binding]; other site 566546010082 active site 566546010083 intracellular protease, PfpI family; Region: PfpI; TIGR01382 566546010084 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 566546010085 proposed catalytic triad [active] 566546010086 conserved cys residue [active] 566546010087 hypothetical protein; Provisional; Region: PRK03467 566546010088 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 566546010089 GIY-YIG motif/motif A; other site 566546010090 putative active site [active] 566546010091 putative metal binding site [ion binding]; other site 566546010092 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 566546010093 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 566546010094 Coenzyme A binding pocket [chemical binding]; other site 566546010095 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 566546010096 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 566546010097 Peptidase family U32; Region: Peptidase_U32; pfam01136 566546010098 putative protease; Provisional; Region: PRK15447 566546010099 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 566546010100 hypothetical protein; Provisional; Region: PRK10508 566546010101 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 566546010102 tryptophan permease; Provisional; Region: PRK10483 566546010103 aromatic amino acid transport protein; Region: araaP; TIGR00837 566546010104 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 566546010105 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 566546010106 ATP binding site [chemical binding]; other site 566546010107 Mg++ binding site [ion binding]; other site 566546010108 motif III; other site 566546010109 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 566546010110 nucleotide binding region [chemical binding]; other site 566546010111 ATP-binding site [chemical binding]; other site 566546010112 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 566546010113 putative RNA binding site [nucleotide binding]; other site 566546010114 lipoprotein NlpI; Provisional; Region: PRK11189 566546010115 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 566546010116 binding surface 566546010117 TPR motif; other site 566546010118 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 566546010119 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 566546010120 RNase E interface [polypeptide binding]; other site 566546010121 trimer interface [polypeptide binding]; other site 566546010122 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 566546010123 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 566546010124 RNase E interface [polypeptide binding]; other site 566546010125 trimer interface [polypeptide binding]; other site 566546010126 active site 566546010127 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 566546010128 putative nucleic acid binding region [nucleotide binding]; other site 566546010129 G-X-X-G motif; other site 566546010130 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 566546010131 RNA binding site [nucleotide binding]; other site 566546010132 domain interface; other site 566546010133 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 566546010134 16S/18S rRNA binding site [nucleotide binding]; other site 566546010135 S13e-L30e interaction site [polypeptide binding]; other site 566546010136 25S rRNA binding site [nucleotide binding]; other site 566546010137 Ribosomal S15 leader; ECW_nc3437 566546010138 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 566546010139 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 566546010140 RNA binding site [nucleotide binding]; other site 566546010141 active site 566546010142 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 566546010143 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 566546010144 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 566546010145 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 566546010146 translation initiation factor IF-2; Region: IF-2; TIGR00487 566546010147 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 566546010148 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 566546010149 G1 box; other site 566546010150 putative GEF interaction site [polypeptide binding]; other site 566546010151 GTP/Mg2+ binding site [chemical binding]; other site 566546010152 Switch I region; other site 566546010153 G2 box; other site 566546010154 G3 box; other site 566546010155 Switch II region; other site 566546010156 G4 box; other site 566546010157 G5 box; other site 566546010158 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 566546010159 Translation-initiation factor 2; Region: IF-2; pfam11987 566546010160 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 566546010161 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 566546010162 NusA N-terminal domain; Region: NusA_N; pfam08529 566546010163 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 566546010164 RNA binding site [nucleotide binding]; other site 566546010165 homodimer interface [polypeptide binding]; other site 566546010166 NusA-like KH domain; Region: KH_5; pfam13184 566546010167 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 566546010168 G-X-X-G motif; other site 566546010169 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 566546010170 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 566546010171 ribosome maturation protein RimP; Reviewed; Region: PRK00092 566546010172 hypothetical protein; Provisional; Region: PRK14641 566546010173 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 566546010174 putative oligomer interface [polypeptide binding]; other site 566546010175 putative RNA binding site [nucleotide binding]; other site 566546010176 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 566546010177 ANP binding site [chemical binding]; other site 566546010178 Substrate Binding Site II [chemical binding]; other site 566546010179 Substrate Binding Site I [chemical binding]; other site 566546010180 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 566546010181 Sulfatase; Region: Sulfatase; pfam00884 566546010182 Preprotein translocase SecG subunit; Region: SecG; pfam03840 566546010183 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 566546010184 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 566546010185 active site 566546010186 substrate binding site [chemical binding]; other site 566546010187 metal binding site [ion binding]; metal-binding site 566546010188 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 566546010189 dihydropteroate synthase; Region: DHPS; TIGR01496 566546010190 substrate binding pocket [chemical binding]; other site 566546010191 dimer interface [polypeptide binding]; other site 566546010192 inhibitor binding site; inhibition site 566546010193 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 566546010194 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546010195 Walker A motif; other site 566546010196 ATP binding site [chemical binding]; other site 566546010197 Walker B motif; other site 566546010198 arginine finger; other site 566546010199 Peptidase family M41; Region: Peptidase_M41; pfam01434 566546010200 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 566546010201 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546010202 S-adenosylmethionine binding site [chemical binding]; other site 566546010203 RNA-binding protein YhbY; Provisional; Region: PRK10343 566546010204 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 566546010205 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 566546010206 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 566546010207 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 566546010208 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 566546010209 GTPase CgtA; Reviewed; Region: obgE; PRK12298 566546010210 GTP1/OBG; Region: GTP1_OBG; pfam01018 566546010211 Obg GTPase; Region: Obg; cd01898 566546010212 G1 box; other site 566546010213 GTP/Mg2+ binding site [chemical binding]; other site 566546010214 Switch I region; other site 566546010215 G2 box; other site 566546010216 G3 box; other site 566546010217 Switch II region; other site 566546010218 G4 box; other site 566546010219 G5 box; other site 566546010220 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 566546010221 EamA-like transporter family; Region: EamA; pfam00892 566546010222 EamA-like transporter family; Region: EamA; pfam00892 566546010223 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 566546010224 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 566546010225 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 566546010226 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 566546010227 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 566546010228 substrate binding pocket [chemical binding]; other site 566546010229 chain length determination region; other site 566546010230 substrate-Mg2+ binding site; other site 566546010231 catalytic residues [active] 566546010232 aspartate-rich region 1; other site 566546010233 active site lid residues [active] 566546010234 aspartate-rich region 2; other site 566546010235 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 566546010236 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 566546010237 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 566546010238 hinge; other site 566546010239 active site 566546010240 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 566546010241 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 566546010242 anti sigma factor interaction site; other site 566546010243 regulatory phosphorylation site [posttranslational modification]; other site 566546010244 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 566546010245 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 566546010246 mce related protein; Region: MCE; pfam02470 566546010247 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 566546010248 conserved hypothetical integral membrane protein; Region: TIGR00056 566546010249 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 566546010250 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 566546010251 Walker A/P-loop; other site 566546010252 ATP binding site [chemical binding]; other site 566546010253 Q-loop/lid; other site 566546010254 ABC transporter signature motif; other site 566546010255 Walker B; other site 566546010256 D-loop; other site 566546010257 H-loop/switch region; other site 566546010258 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 566546010259 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 566546010260 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 566546010261 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 566546010262 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 566546010263 putative active site [active] 566546010264 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 566546010265 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 566546010266 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 566546010267 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 566546010268 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 566546010269 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 566546010270 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 566546010271 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 566546010272 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 566546010273 Walker A/P-loop; other site 566546010274 ATP binding site [chemical binding]; other site 566546010275 Q-loop/lid; other site 566546010276 ABC transporter signature motif; other site 566546010277 Walker B; other site 566546010278 D-loop; other site 566546010279 H-loop/switch region; other site 566546010280 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 566546010281 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 566546010282 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 566546010283 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 566546010284 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 566546010285 30S subunit binding site; other site 566546010286 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 566546010287 active site 566546010288 phosphorylation site [posttranslational modification] 566546010289 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 566546010290 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 566546010291 dimerization domain swap beta strand [polypeptide binding]; other site 566546010292 regulatory protein interface [polypeptide binding]; other site 566546010293 active site 566546010294 regulatory phosphorylation site [posttranslational modification]; other site 566546010295 hypothetical protein; Provisional; Region: PRK10345 566546010296 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 566546010297 Transglycosylase; Region: Transgly; cl17702 566546010298 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 566546010299 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 566546010300 conserved cys residue [active] 566546010301 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 566546010302 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 566546010303 putative active site [active] 566546010304 heme pocket [chemical binding]; other site 566546010305 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 566546010306 dimer interface [polypeptide binding]; other site 566546010307 phosphorylation site [posttranslational modification] 566546010308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546010309 ATP binding site [chemical binding]; other site 566546010310 Mg2+ binding site [ion binding]; other site 566546010311 G-X-G motif; other site 566546010312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546010313 active site 566546010314 phosphorylation site [posttranslational modification] 566546010315 intermolecular recognition site; other site 566546010316 dimerization interface [polypeptide binding]; other site 566546010317 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 566546010318 putative binding surface; other site 566546010319 active site 566546010320 radical SAM protein, TIGR01212 family; Region: TIGR01212 566546010321 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 566546010322 FeS/SAM binding site; other site 566546010323 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 566546010324 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 566546010325 active site 566546010326 dimer interface [polypeptide binding]; other site 566546010327 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 566546010328 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 566546010329 active site 566546010330 FMN binding site [chemical binding]; other site 566546010331 substrate binding site [chemical binding]; other site 566546010332 3Fe-4S cluster binding site [ion binding]; other site 566546010333 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 566546010334 domain interface; other site 566546010335 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 566546010336 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 566546010337 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 566546010338 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 566546010339 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 566546010340 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 566546010341 N-acetylmannosamine kinase; Provisional; Region: PRK05082 566546010342 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 566546010343 nucleotide binding site [chemical binding]; other site 566546010344 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 566546010345 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 566546010346 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 566546010347 putative active site cavity [active] 566546010348 putative sialic acid transporter; Provisional; Region: PRK03893 566546010349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546010350 putative substrate translocation pore; other site 566546010351 N-acetylneuraminate lyase; Region: nanA; TIGR00683 566546010352 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 566546010353 inhibitor site; inhibition site 566546010354 active site 566546010355 dimer interface [polypeptide binding]; other site 566546010356 catalytic residue [active] 566546010357 transcriptional regulator NanR; Provisional; Region: PRK03837 566546010358 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 566546010359 DNA-binding site [nucleotide binding]; DNA binding site 566546010360 FCD domain; Region: FCD; pfam07729 566546010361 putative cryptic C4-dicarboxylate transporter DcuD; Provisional; Region: PRK09804 566546010362 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 566546010363 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 566546010364 stringent starvation protein A; Provisional; Region: sspA; PRK09481 566546010365 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 566546010366 C-terminal domain interface [polypeptide binding]; other site 566546010367 putative GSH binding site (G-site) [chemical binding]; other site 566546010368 dimer interface [polypeptide binding]; other site 566546010369 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 566546010370 dimer interface [polypeptide binding]; other site 566546010371 N-terminal domain interface [polypeptide binding]; other site 566546010372 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 566546010373 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 566546010374 23S rRNA interface [nucleotide binding]; other site 566546010375 L3 interface [polypeptide binding]; other site 566546010376 Predicted ATPase [General function prediction only]; Region: COG1485 566546010377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 566546010378 hypothetical protein; Provisional; Region: PRK11677 566546010379 serine endoprotease; Provisional; Region: PRK10139 566546010380 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 566546010381 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 566546010382 protein binding site [polypeptide binding]; other site 566546010383 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 566546010384 serine endoprotease; Provisional; Region: PRK10898 566546010385 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 566546010386 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 566546010387 malate dehydrogenase; Provisional; Region: PRK05086 566546010388 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 566546010389 NAD binding site [chemical binding]; other site 566546010390 dimerization interface [polypeptide binding]; other site 566546010391 Substrate binding site [chemical binding]; other site 566546010392 arginine repressor; Provisional; Region: PRK05066 566546010393 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 566546010394 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 566546010395 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 566546010396 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 566546010397 RNAase interaction site [polypeptide binding]; other site 566546010398 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 566546010399 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 566546010400 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 566546010401 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 566546010402 HlyD family secretion protein; Region: HlyD_3; pfam13437 566546010403 efflux system membrane protein; Provisional; Region: PRK11594 566546010404 transcriptional regulator; Provisional; Region: PRK10632 566546010405 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546010406 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 566546010407 putative effector binding pocket; other site 566546010408 dimerization interface [polypeptide binding]; other site 566546010409 protease TldD; Provisional; Region: tldD; PRK10735 566546010410 hypothetical protein; Provisional; Region: PRK10899 566546010411 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 566546010412 ribonuclease G; Provisional; Region: PRK11712 566546010413 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 566546010414 homodimer interface [polypeptide binding]; other site 566546010415 oligonucleotide binding site [chemical binding]; other site 566546010416 Maf-like protein; Region: Maf; pfam02545 566546010417 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 566546010418 active site 566546010419 dimer interface [polypeptide binding]; other site 566546010420 rod shape-determining protein MreD; Provisional; Region: PRK11060 566546010421 rod shape-determining protein MreC; Region: mreC; TIGR00219 566546010422 rod shape-determining protein MreC; Region: MreC; pfam04085 566546010423 rod shape-determining protein MreB; Provisional; Region: PRK13927 566546010424 MreB and similar proteins; Region: MreB_like; cd10225 566546010425 nucleotide binding site [chemical binding]; other site 566546010426 Mg binding site [ion binding]; other site 566546010427 putative protofilament interaction site [polypeptide binding]; other site 566546010428 RodZ interaction site [polypeptide binding]; other site 566546010429 regulatory protein CsrD; Provisional; Region: PRK11059 566546010430 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 566546010431 metal binding site [ion binding]; metal-binding site 566546010432 active site 566546010433 I-site; other site 566546010434 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 566546010435 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 566546010436 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 566546010437 NADP binding site [chemical binding]; other site 566546010438 dimer interface [polypeptide binding]; other site 566546010439 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 566546010440 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 566546010441 carboxyltransferase (CT) interaction site; other site 566546010442 biotinylation site [posttranslational modification]; other site 566546010443 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 566546010444 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 566546010445 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 566546010446 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 566546010447 hypothetical protein; Provisional; Region: PRK10633 566546010448 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 566546010449 Na binding site [ion binding]; other site 566546010450 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 566546010451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 566546010452 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 566546010453 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 566546010454 FMN binding site [chemical binding]; other site 566546010455 active site 566546010456 catalytic residues [active] 566546010457 substrate binding site [chemical binding]; other site 566546010458 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 566546010459 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 566546010460 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 566546010461 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546010462 DNA methylase; Region: N6_N4_Mtase; pfam01555 566546010463 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 566546010464 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 566546010465 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 566546010466 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 566546010467 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 566546010468 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 566546010469 HlyD family secretion protein; Region: HlyD_3; pfam13437 566546010470 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 566546010471 Protein export membrane protein; Region: SecD_SecF; cl14618 566546010472 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 566546010473 pseudogene, extracellular solute-binding protein 566546010474 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 566546010475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546010476 conserved gate region; other site 566546010477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546010478 dimer interface [polypeptide binding]; other site 566546010479 conserved gate region; other site 566546010480 putative PBP binding loops; other site 566546010481 ABC-ATPase subunit interface; other site 566546010482 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 566546010483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546010484 dimer interface [polypeptide binding]; other site 566546010485 conserved gate region; other site 566546010486 putative PBP binding loops; other site 566546010487 ABC-ATPase subunit interface; other site 566546010488 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 566546010489 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 566546010490 Walker A/P-loop; other site 566546010491 ATP binding site [chemical binding]; other site 566546010492 Q-loop/lid; other site 566546010493 ABC transporter signature motif; other site 566546010494 Walker B; other site 566546010495 D-loop; other site 566546010496 H-loop/switch region; other site 566546010497 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 566546010498 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 566546010499 trimer interface [polypeptide binding]; other site 566546010500 putative metal binding site [ion binding]; other site 566546010501 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 566546010502 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 566546010503 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 566546010504 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 566546010505 shikimate binding site; other site 566546010506 NAD(P) binding site [chemical binding]; other site 566546010507 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 566546010508 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 566546010509 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 566546010510 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 566546010511 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 566546010512 hypothetical protein; Validated; Region: PRK03430 566546010513 hypothetical protein; Provisional; Region: PRK10736 566546010514 DNA protecting protein DprA; Region: dprA; TIGR00732 566546010515 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 566546010516 active site 566546010517 catalytic residues [active] 566546010518 metal binding site [ion binding]; metal-binding site 566546010519 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 566546010520 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 566546010521 putative active site [active] 566546010522 substrate binding site [chemical binding]; other site 566546010523 putative cosubstrate binding site; other site 566546010524 catalytic site [active] 566546010525 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 566546010526 substrate binding site [chemical binding]; other site 566546010527 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 566546010528 putative RNA binding site [nucleotide binding]; other site 566546010529 16S rRNA methyltransferase B; Provisional; Region: PRK10901 566546010530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546010531 S-adenosylmethionine binding site [chemical binding]; other site 566546010532 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 566546010533 TrkA-N domain; Region: TrkA_N; pfam02254 566546010534 TrkA-C domain; Region: TrkA_C; pfam02080 566546010535 TrkA-N domain; Region: TrkA_N; pfam02254 566546010536 TrkA-C domain; Region: TrkA_C; pfam02080 566546010537 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 566546010538 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 566546010539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 566546010540 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 566546010541 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 566546010542 DNA binding residues [nucleotide binding] 566546010543 dimer interface [polypeptide binding]; other site 566546010544 metal binding site [ion binding]; metal-binding site 566546010545 hypothetical protein; Provisional; Region: PRK10203 566546010546 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 566546010547 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 566546010548 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 566546010549 alphaNTD homodimer interface [polypeptide binding]; other site 566546010550 alphaNTD - beta interaction site [polypeptide binding]; other site 566546010551 alphaNTD - beta' interaction site [polypeptide binding]; other site 566546010552 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 566546010553 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 566546010554 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 566546010555 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 566546010556 RNA binding surface [nucleotide binding]; other site 566546010557 30S ribosomal protein S11; Validated; Region: PRK05309 566546010558 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 566546010559 30S ribosomal protein S13; Region: bact_S13; TIGR03631 566546010560 alpha operon ribosome binding site; ECW_nc3567 566546010561 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 566546010562 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 566546010563 SecY translocase; Region: SecY; pfam00344 566546010564 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 566546010565 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 566546010566 23S rRNA binding site [nucleotide binding]; other site 566546010567 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 566546010568 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 566546010569 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 566546010570 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 566546010571 23S rRNA interface [nucleotide binding]; other site 566546010572 5S rRNA interface [nucleotide binding]; other site 566546010573 L27 interface [polypeptide binding]; other site 566546010574 L5 interface [polypeptide binding]; other site 566546010575 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 566546010576 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 566546010577 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 566546010578 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 566546010579 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 566546010580 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 566546010581 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 566546010582 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 566546010583 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 566546010584 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 566546010585 RNA binding site [nucleotide binding]; other site 566546010586 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 566546010587 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 566546010588 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 566546010589 23S rRNA interface [nucleotide binding]; other site 566546010590 putative translocon interaction site; other site 566546010591 signal recognition particle (SRP54) interaction site; other site 566546010592 L23 interface [polypeptide binding]; other site 566546010593 trigger factor interaction site; other site 566546010594 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 566546010595 23S rRNA interface [nucleotide binding]; other site 566546010596 5S rRNA interface [nucleotide binding]; other site 566546010597 putative antibiotic binding site [chemical binding]; other site 566546010598 L25 interface [polypeptide binding]; other site 566546010599 L27 interface [polypeptide binding]; other site 566546010600 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 566546010601 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 566546010602 G-X-X-G motif; other site 566546010603 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 566546010604 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 566546010605 protein-rRNA interface [nucleotide binding]; other site 566546010606 putative translocon binding site; other site 566546010607 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 566546010608 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 566546010609 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 566546010610 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 566546010611 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 566546010612 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 566546010613 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 566546010614 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 566546010615 pseudogene, bifunctional prepilin leader peptidase/methylase 566546010616 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 566546010617 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 566546010618 heme binding site [chemical binding]; other site 566546010619 ferroxidase pore; other site 566546010620 ferroxidase diiron center [ion binding]; other site 566546010621 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 566546010622 elongation factor Tu; Reviewed; Region: PRK00049 566546010623 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 566546010624 G1 box; other site 566546010625 GEF interaction site [polypeptide binding]; other site 566546010626 GTP/Mg2+ binding site [chemical binding]; other site 566546010627 Switch I region; other site 566546010628 G2 box; other site 566546010629 G3 box; other site 566546010630 Switch II region; other site 566546010631 G4 box; other site 566546010632 G5 box; other site 566546010633 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 566546010634 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 566546010635 Antibiotic Binding Site [chemical binding]; other site 566546010636 elongation factor G; Reviewed; Region: PRK00007 566546010637 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 566546010638 G1 box; other site 566546010639 putative GEF interaction site [polypeptide binding]; other site 566546010640 GTP/Mg2+ binding site [chemical binding]; other site 566546010641 Switch I region; other site 566546010642 G2 box; other site 566546010643 G3 box; other site 566546010644 Switch II region; other site 566546010645 G4 box; other site 566546010646 G5 box; other site 566546010647 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 566546010648 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 566546010649 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 566546010650 30S ribosomal protein S7; Validated; Region: PRK05302 566546010651 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 566546010652 S17 interaction site [polypeptide binding]; other site 566546010653 S8 interaction site; other site 566546010654 16S rRNA interaction site [nucleotide binding]; other site 566546010655 streptomycin interaction site [chemical binding]; other site 566546010656 23S rRNA interaction site [nucleotide binding]; other site 566546010657 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 566546010658 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 566546010659 sulfur relay protein TusC; Validated; Region: PRK00211 566546010660 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 566546010661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 566546010662 YheO-like PAS domain; Region: PAS_6; pfam08348 566546010663 HTH domain; Region: HTH_22; pfam13309 566546010664 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 566546010665 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 566546010666 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 566546010667 phi X174 lysis protein; Provisional; Region: PRK02793 566546010668 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 566546010669 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 566546010670 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 566546010671 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 566546010672 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 566546010673 TrkA-N domain; Region: TrkA_N; pfam02254 566546010674 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 566546010675 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 566546010676 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 566546010677 Walker A/P-loop; other site 566546010678 ATP binding site [chemical binding]; other site 566546010679 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 566546010680 ABC transporter signature motif; other site 566546010681 Walker B; other site 566546010682 D-loop; other site 566546010683 ABC transporter; Region: ABC_tran_2; pfam12848 566546010684 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 566546010685 putative hydrolase; Provisional; Region: PRK10985 566546010686 hypothetical protein; Provisional; Region: PRK04966 566546010687 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 566546010688 active site 566546010689 hypothetical protein; Provisional; Region: PRK10738 566546010690 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 566546010691 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 566546010692 ligand binding site [chemical binding]; other site 566546010693 flexible hinge region; other site 566546010694 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 566546010695 putative switch regulator; other site 566546010696 non-specific DNA interactions [nucleotide binding]; other site 566546010697 DNA binding site [nucleotide binding] 566546010698 sequence specific DNA binding site [nucleotide binding]; other site 566546010699 putative cAMP binding site [chemical binding]; other site 566546010700 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 566546010701 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 566546010702 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 566546010703 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 566546010704 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 566546010705 inhibitor-cofactor binding pocket; inhibition site 566546010706 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546010707 catalytic residue [active] 566546010708 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 566546010709 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 566546010710 glutamine binding [chemical binding]; other site 566546010711 catalytic triad [active] 566546010712 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 566546010713 cell filamentation protein Fic; Provisional; Region: PRK10347 566546010714 hypothetical protein; Provisional; Region: PRK10204 566546010715 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 566546010716 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 566546010717 substrate binding site [chemical binding]; other site 566546010718 putative transporter; Provisional; Region: PRK03699 566546010719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546010720 putative substrate translocation pore; other site 566546010721 nitrite reductase subunit NirD; Provisional; Region: PRK14989 566546010722 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 566546010723 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 566546010724 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 566546010725 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 566546010726 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 566546010727 nitrite transporter NirC; Provisional; Region: PRK11562 566546010728 siroheme synthase; Provisional; Region: cysG; PRK10637 566546010729 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 566546010730 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 566546010731 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 566546010732 active site 566546010733 SAM binding site [chemical binding]; other site 566546010734 homodimer interface [polypeptide binding]; other site 566546010735 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 566546010736 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 566546010737 hypothetical protein; Provisional; Region: PHA02764 566546010738 fructoselysine-6-P-deglycase; Provisional; Region: frlB; PRK11382 566546010739 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 566546010740 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 566546010741 dimer interface [polypeptide binding]; other site 566546010742 active site 566546010743 fructoselysine 3-epimerase; Provisional; Region: PRK09856 566546010744 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 566546010745 AP (apurinic/apyrimidinic) site pocket; other site 566546010746 DNA interaction; other site 566546010747 Metal-binding active site; metal-binding site 566546010748 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 566546010749 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 566546010750 substrate binding site [chemical binding]; other site 566546010751 ATP binding site [chemical binding]; other site 566546010752 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 566546010753 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 566546010754 DNA-binding site [nucleotide binding]; DNA binding site 566546010755 UTRA domain; Region: UTRA; pfam07702 566546010756 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 566546010757 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 566546010758 Protein of unknown function; Region: YhfT; pfam10797 566546010759 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 566546010760 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 566546010761 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 566546010762 active site 566546010763 substrate binding pocket [chemical binding]; other site 566546010764 homodimer interaction site [polypeptide binding]; other site 566546010765 putative mutase; Provisional; Region: PRK12383 566546010766 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015 566546010767 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 566546010768 dimer interface [polypeptide binding]; other site 566546010769 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 566546010770 active site 566546010771 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 566546010772 substrate binding site [chemical binding]; other site 566546010773 catalytic residue [active] 566546010774 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 566546010775 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 566546010776 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 566546010777 active site 566546010778 HIGH motif; other site 566546010779 dimer interface [polypeptide binding]; other site 566546010780 KMSKS motif; other site 566546010781 phosphoglycolate phosphatase; Provisional; Region: PRK13222 566546010782 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 566546010783 motif II; other site 566546010784 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 566546010785 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 566546010786 substrate binding site [chemical binding]; other site 566546010787 hexamer interface [polypeptide binding]; other site 566546010788 metal binding site [ion binding]; metal-binding site 566546010789 DNA adenine methylase; Provisional; Region: PRK10904 566546010790 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 566546010791 cell division protein DamX; Validated; Region: PRK10905 566546010792 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 566546010793 active site 566546010794 dimer interface [polypeptide binding]; other site 566546010795 metal binding site [ion binding]; metal-binding site 566546010796 shikimate kinase; Reviewed; Region: aroK; PRK00131 566546010797 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 566546010798 ADP binding site [chemical binding]; other site 566546010799 magnesium binding site [ion binding]; other site 566546010800 putative shikimate binding site; other site 566546010801 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 566546010802 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 566546010803 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 566546010804 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 566546010805 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 566546010806 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 566546010807 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 566546010808 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 566546010809 Transglycosylase; Region: Transgly; pfam00912 566546010810 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 566546010811 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 566546010812 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 566546010813 ADP-ribose binding site [chemical binding]; other site 566546010814 dimer interface [polypeptide binding]; other site 566546010815 active site 566546010816 nudix motif; other site 566546010817 metal binding site [ion binding]; metal-binding site 566546010818 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 566546010819 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 566546010820 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 566546010821 motif II; other site 566546010822 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 566546010823 RNA binding surface [nucleotide binding]; other site 566546010824 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 566546010825 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 566546010826 dimerization interface [polypeptide binding]; other site 566546010827 domain crossover interface; other site 566546010828 redox-dependent activation switch; other site 566546010829 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 566546010830 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 566546010831 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 566546010832 active site 566546010833 substrate-binding site [chemical binding]; other site 566546010834 metal-binding site [ion binding] 566546010835 ATP binding site [chemical binding]; other site 566546010836 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 566546010837 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 566546010838 non-specific DNA binding site [nucleotide binding]; other site 566546010839 salt bridge; other site 566546010840 sequence-specific DNA binding site [nucleotide binding]; other site 566546010841 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 566546010842 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 566546010843 dimerization interface [polypeptide binding]; other site 566546010844 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 566546010845 dimer interface [polypeptide binding]; other site 566546010846 phosphorylation site [posttranslational modification] 566546010847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546010848 ATP binding site [chemical binding]; other site 566546010849 G-X-G motif; other site 566546010850 osmolarity response regulator; Provisional; Region: ompR; PRK09468 566546010851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546010852 active site 566546010853 phosphorylation site [posttranslational modification] 566546010854 intermolecular recognition site; other site 566546010855 dimerization interface [polypeptide binding]; other site 566546010856 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 566546010857 DNA binding site [nucleotide binding] 566546010858 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 566546010859 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 566546010860 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 566546010861 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 566546010862 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 566546010863 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 566546010864 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 566546010865 RNA binding site [nucleotide binding]; other site 566546010866 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 566546010867 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 566546010868 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 566546010869 G1 box; other site 566546010870 GTP/Mg2+ binding site [chemical binding]; other site 566546010871 Switch I region; other site 566546010872 G2 box; other site 566546010873 G3 box; other site 566546010874 Switch II region; other site 566546010875 G4 box; other site 566546010876 G5 box; other site 566546010877 Nucleoside recognition; Region: Gate; pfam07670 566546010878 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 566546010879 Nucleoside recognition; Region: Gate; pfam07670 566546010880 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 566546010881 pseudogene, predicted transposase Fragment 566546010882 pseudogene, predicted transposase Fragment 566546010883 carboxylesterase BioH; Provisional; Region: PRK10349 566546010884 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 566546010885 DNA utilization protein GntX; Provisional; Region: PRK11595 566546010886 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 566546010887 active site 566546010888 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 566546010889 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 566546010890 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 566546010891 high-affinity gluconate transporter; Provisional; Region: PRK14984 566546010892 gluconate transporter; Region: gntP; TIGR00791 566546010893 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 566546010894 4-alpha-glucanotransferase; Region: malQ; TIGR00217 566546010895 maltodextrin phosphorylase; Provisional; Region: PRK14985 566546010896 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 566546010897 homodimer interface [polypeptide binding]; other site 566546010898 active site pocket [active] 566546010899 transcriptional regulator MalT; Provisional; Region: PRK04841 566546010900 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 566546010901 DNA binding residues [nucleotide binding] 566546010902 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 566546010903 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 566546010904 putative active site [active] 566546010905 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 566546010906 hypothetical protein; Reviewed; Region: PRK09588 566546010907 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 566546010908 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 566546010909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546010910 Walker A motif; other site 566546010911 ATP binding site [chemical binding]; other site 566546010912 Walker B motif; other site 566546010913 arginine finger; other site 566546010914 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 566546010915 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 566546010916 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 566546010917 intramembrane serine protease GlpG; Provisional; Region: PRK10907 566546010918 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 566546010919 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 566546010920 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 566546010921 active site residue [active] 566546010922 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 566546010923 hypothetical protein; Provisional; Region: PRK09781; cl08057 566546010924 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 566546010925 glycogen phosphorylase; Provisional; Region: PRK14986 566546010926 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 566546010927 homodimer interface [polypeptide binding]; other site 566546010928 active site pocket [active] 566546010929 glycogen synthase; Provisional; Region: glgA; PRK00654 566546010930 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 566546010931 ADP-binding pocket [chemical binding]; other site 566546010932 homodimer interface [polypeptide binding]; other site 566546010933 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 566546010934 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 566546010935 ligand binding site; other site 566546010936 oligomer interface; other site 566546010937 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 566546010938 sulfate 1 binding site; other site 566546010939 glycogen debranching enzyme; Provisional; Region: PRK03705 566546010940 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 566546010941 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 566546010942 active site 566546010943 catalytic site [active] 566546010944 glycogen branching enzyme; Provisional; Region: PRK05402 566546010945 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 566546010946 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 566546010947 active site 566546010948 catalytic site [active] 566546010949 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 566546010950 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 566546010951 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 566546010952 putative antibiotic transporter; Provisional; Region: PRK10739 566546010953 low affinity gluconate transporter; Provisional; Region: PRK10472 566546010954 gluconate transporter; Region: gntP; TIGR00791 566546010955 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 566546010956 Shikimate kinase; Region: SKI; pfam01202 566546010957 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 566546010958 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 566546010959 DNA binding site [nucleotide binding] 566546010960 domain linker motif; other site 566546010961 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 566546010962 putative ligand binding site [chemical binding]; other site 566546010963 putative dimerization interface [polypeptide binding]; other site 566546010964 Pirin-related protein [General function prediction only]; Region: COG1741 566546010965 Pirin; Region: Pirin; pfam02678 566546010966 putative oxidoreductase; Provisional; Region: PRK10206 566546010967 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 566546010968 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 566546010969 putative acetyltransferase YhhY; Provisional; Region: PRK10140 566546010970 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 566546010971 Coenzyme A binding pocket [chemical binding]; other site 566546010972 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 566546010973 pseudogene, conserved hypothetical protein 566546010974 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 566546010975 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 566546010976 hypothetical protein; Provisional; Region: PRK10350 566546010977 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 566546010978 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 566546010979 putative active site [active] 566546010980 catalytic site [active] 566546010981 putative metal binding site [ion binding]; other site 566546010982 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 566546010983 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 566546010984 Walker A/P-loop; other site 566546010985 ATP binding site [chemical binding]; other site 566546010986 Q-loop/lid; other site 566546010987 ABC transporter signature motif; other site 566546010988 Walker B; other site 566546010989 D-loop; other site 566546010990 H-loop/switch region; other site 566546010991 TOBE domain; Region: TOBE_2; pfam08402 566546010992 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 566546010993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546010994 dimer interface [polypeptide binding]; other site 566546010995 conserved gate region; other site 566546010996 putative PBP binding loops; other site 566546010997 ABC-ATPase subunit interface; other site 566546010998 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 566546010999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546011000 dimer interface [polypeptide binding]; other site 566546011001 conserved gate region; other site 566546011002 putative PBP binding loops; other site 566546011003 ABC-ATPase subunit interface; other site 566546011004 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 566546011005 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 566546011006 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 566546011007 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 566546011008 Walker A/P-loop; other site 566546011009 ATP binding site [chemical binding]; other site 566546011010 Q-loop/lid; other site 566546011011 ABC transporter signature motif; other site 566546011012 Walker B; other site 566546011013 D-loop; other site 566546011014 H-loop/switch region; other site 566546011015 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 566546011016 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 566546011017 Walker A/P-loop; other site 566546011018 ATP binding site [chemical binding]; other site 566546011019 Q-loop/lid; other site 566546011020 ABC transporter signature motif; other site 566546011021 Walker B; other site 566546011022 D-loop; other site 566546011023 H-loop/switch region; other site 566546011024 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 566546011025 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 566546011026 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 566546011027 TM-ABC transporter signature motif; other site 566546011028 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 566546011029 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 566546011030 TM-ABC transporter signature motif; other site 566546011031 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 566546011032 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 566546011033 dimerization interface [polypeptide binding]; other site 566546011034 ligand binding site [chemical binding]; other site 566546011035 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 566546011036 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 566546011037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 566546011038 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 566546011039 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 566546011040 dimerization interface [polypeptide binding]; other site 566546011041 ligand binding site [chemical binding]; other site 566546011042 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 566546011043 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 566546011044 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 566546011045 DNA binding residues [nucleotide binding] 566546011046 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 566546011047 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 566546011048 cell division protein FtsE; Provisional; Region: PRK10908 566546011049 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 566546011050 Walker A/P-loop; other site 566546011051 ATP binding site [chemical binding]; other site 566546011052 Q-loop/lid; other site 566546011053 ABC transporter signature motif; other site 566546011054 Walker B; other site 566546011055 D-loop; other site 566546011056 H-loop/switch region; other site 566546011057 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 566546011058 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 566546011059 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 566546011060 P loop; other site 566546011061 GTP binding site [chemical binding]; other site 566546011062 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 566546011063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546011064 S-adenosylmethionine binding site [chemical binding]; other site 566546011065 hypothetical protein; Provisional; Region: PRK10910 566546011066 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 566546011067 Predicted membrane protein [Function unknown]; Region: COG3714 566546011068 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 566546011069 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 566546011070 metal-binding site [ion binding] 566546011071 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 566546011072 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 566546011073 CPxP motif; other site 566546011074 hypothetical protein; Provisional; Region: PRK11212 566546011075 hypothetical protein; Provisional; Region: PRK11615 566546011076 major facilitator superfamily transporter; Provisional; Region: PRK05122 566546011077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546011078 putative substrate translocation pore; other site 566546011079 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 566546011080 Domain of unknown function DUF20; Region: UPF0118; pfam01594 566546011081 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 566546011082 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 566546011083 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 566546011084 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 566546011085 substrate binding site [chemical binding]; other site 566546011086 nickel transporter permease NikB; Provisional; Region: PRK10352 566546011087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546011088 dimer interface [polypeptide binding]; other site 566546011089 conserved gate region; other site 566546011090 putative PBP binding loops; other site 566546011091 ABC-ATPase subunit interface; other site 566546011092 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 566546011093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546011094 dimer interface [polypeptide binding]; other site 566546011095 conserved gate region; other site 566546011096 putative PBP binding loops; other site 566546011097 ABC-ATPase subunit interface; other site 566546011098 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 566546011099 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 566546011100 Walker A/P-loop; other site 566546011101 ATP binding site [chemical binding]; other site 566546011102 Q-loop/lid; other site 566546011103 ABC transporter signature motif; other site 566546011104 Walker B; other site 566546011105 D-loop; other site 566546011106 H-loop/switch region; other site 566546011107 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 566546011108 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 566546011109 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 566546011110 Walker A/P-loop; other site 566546011111 ATP binding site [chemical binding]; other site 566546011112 Q-loop/lid; other site 566546011113 ABC transporter signature motif; other site 566546011114 Walker B; other site 566546011115 D-loop; other site 566546011116 H-loop/switch region; other site 566546011117 nickel responsive regulator; Provisional; Region: PRK02967 566546011118 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 566546011119 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 566546011120 HicB family; Region: HicB; pfam05534 566546011121 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 566546011122 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 566546011123 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 566546011124 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 566546011125 Walker A/P-loop; other site 566546011126 ATP binding site [chemical binding]; other site 566546011127 Q-loop/lid; other site 566546011128 ABC transporter signature motif; other site 566546011129 Walker B; other site 566546011130 D-loop; other site 566546011131 H-loop/switch region; other site 566546011132 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 566546011133 Walker A/P-loop; other site 566546011134 ATP binding site [chemical binding]; other site 566546011135 Q-loop/lid; other site 566546011136 ABC transporter signature motif; other site 566546011137 Walker B; other site 566546011138 D-loop; other site 566546011139 H-loop/switch region; other site 566546011140 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 566546011141 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 566546011142 HlyD family secretion protein; Region: HlyD; pfam00529 566546011143 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 566546011144 HlyD family secretion protein; Region: HlyD_3; pfam13437 566546011145 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 566546011146 pseudogene, conserved hypothetical protein 566546011147 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 566546011148 Predicted flavoproteins [General function prediction only]; Region: COG2081 566546011149 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 566546011150 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 566546011151 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 566546011152 universal stress protein UspB; Provisional; Region: PRK04960 566546011153 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 566546011154 Ligand Binding Site [chemical binding]; other site 566546011155 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 566546011156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546011157 putative substrate translocation pore; other site 566546011158 POT family; Region: PTR2; pfam00854 566546011159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546011160 S-adenosylmethionine binding site [chemical binding]; other site 566546011161 oligopeptidase A; Provisional; Region: PRK10911 566546011162 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 566546011163 active site 566546011164 Zn binding site [ion binding]; other site 566546011165 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 566546011166 glutathione reductase; Validated; Region: PRK06116 566546011167 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 566546011168 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 566546011169 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 566546011170 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 566546011171 dimerization interface [polypeptide binding]; other site 566546011172 putative DNA binding site [nucleotide binding]; other site 566546011173 putative Zn2+ binding site [ion binding]; other site 566546011174 arsenical pump membrane protein; Provisional; Region: PRK15445 566546011175 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 566546011176 transmembrane helices; other site 566546011177 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 566546011178 ArsC family; Region: ArsC; pfam03960 566546011179 catalytic residues [active] 566546011180 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 566546011181 dimerization interface [polypeptide binding]; other site 566546011182 putative DNA binding site [nucleotide binding]; other site 566546011183 putative Zn2+ binding site [ion binding]; other site 566546011184 Predicted permeases [General function prediction only]; Region: COG0701 566546011185 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 566546011186 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 566546011187 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 566546011188 DNA binding residues [nucleotide binding] 566546011189 dimerization interface [polypeptide binding]; other site 566546011190 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 566546011191 MgtC family; Region: MgtC; pfam02308 566546011192 acid-resistance protein; Provisional; Region: hdeB; PRK11566 566546011193 acid-resistance protein; Provisional; Region: PRK10208 566546011194 acid-resistance membrane protein; Provisional; Region: PRK10209 566546011195 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 566546011196 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 566546011197 pyruvate kinase; Provisional; Region: PRK05826 566546011198 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 566546011199 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 566546011200 HlyD family secretion protein; Region: HlyD_3; pfam13437 566546011201 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 566546011202 Protein export membrane protein; Region: SecD_SecF; cl14618 566546011203 transcriptional regulator YdeO; Provisional; Region: PRK09940 566546011204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546011205 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 566546011206 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546011207 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 566546011208 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546011209 catalytic residue [active] 566546011210 Haem-binding domain; Region: Haem_bd; pfam14376 566546011211 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 566546011212 trehalase; Provisional; Region: treF; PRK13270 566546011213 Trehalase; Region: Trehalase; pfam01204 566546011214 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 566546011215 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 566546011216 DNA binding residues [nucleotide binding] 566546011217 dimerization interface [polypeptide binding]; other site 566546011218 Transcriptional regulator [Transcription]; Region: LysR; COG0583 566546011219 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546011220 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 566546011221 putative effector binding pocket; other site 566546011222 putative dimerization interface [polypeptide binding]; other site 566546011223 inner membrane protein YhjD; Region: TIGR00766 566546011224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546011225 metabolite-proton symporter; Region: 2A0106; TIGR00883 566546011226 putative substrate translocation pore; other site 566546011227 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 566546011228 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 566546011229 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 566546011230 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 566546011231 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 566546011232 substrate binding site [chemical binding]; other site 566546011233 ATP binding site [chemical binding]; other site 566546011234 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 566546011235 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 566546011236 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 566546011237 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 566546011238 putative diguanylate cyclase; Provisional; Region: PRK13561 566546011239 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 566546011240 metal binding site [ion binding]; metal-binding site 566546011241 active site 566546011242 I-site; other site 566546011243 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 566546011244 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 566546011245 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 566546011246 binding surface 566546011247 TPR motif; other site 566546011248 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 566546011249 binding surface 566546011250 TPR motif; other site 566546011251 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 566546011252 endo-1,4-D-glucanase; Provisional; Region: PRK11097 566546011253 cellulose synthase regulator protein; Provisional; Region: PRK11114 566546011254 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 566546011255 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 566546011256 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 566546011257 DXD motif; other site 566546011258 PilZ domain; Region: PilZ; pfam07238 566546011259 pseudogene, cellulose synthase operon protein YhjQ 566546011260 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 566546011261 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 566546011262 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 566546011263 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 566546011264 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 566546011265 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 566546011266 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 566546011267 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 566546011268 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 566546011269 serine transporter; Region: stp; TIGR00814 566546011270 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 566546011271 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 566546011272 Walker A/P-loop; other site 566546011273 ATP binding site [chemical binding]; other site 566546011274 Q-loop/lid; other site 566546011275 ABC transporter signature motif; other site 566546011276 Walker B; other site 566546011277 D-loop; other site 566546011278 H-loop/switch region; other site 566546011279 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 566546011280 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 566546011281 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 566546011282 Walker A/P-loop; other site 566546011283 ATP binding site [chemical binding]; other site 566546011284 Q-loop/lid; other site 566546011285 ABC transporter signature motif; other site 566546011286 Walker B; other site 566546011287 D-loop; other site 566546011288 H-loop/switch region; other site 566546011289 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 566546011290 dipeptide transporter; Provisional; Region: PRK10913 566546011291 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 566546011292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546011293 dimer interface [polypeptide binding]; other site 566546011294 conserved gate region; other site 566546011295 putative PBP binding loops; other site 566546011296 ABC-ATPase subunit interface; other site 566546011297 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 566546011298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546011299 dimer interface [polypeptide binding]; other site 566546011300 conserved gate region; other site 566546011301 putative PBP binding loops; other site 566546011302 ABC-ATPase subunit interface; other site 566546011303 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 566546011304 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 566546011305 peptide binding site [polypeptide binding]; other site 566546011306 phosphoethanolamine transferase; Provisional; Region: PRK11560 566546011307 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 566546011308 Sulfatase; Region: Sulfatase; pfam00884 566546011309 long polar fimbrial protein LpfE; Provisional; Region: PRK15205 566546011310 long polar fimbrial protein LpfD; Provisional; Region: PRK15206 566546011311 long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207 566546011312 PapC N-terminal domain; Region: PapC_N; pfam13954 566546011313 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 566546011314 PapC C-terminal domain; Region: PapC_C; pfam13953 566546011315 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 566546011316 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 566546011317 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 566546011318 long polar fimbrial protein LpfA; Provisional; Region: PRK15209 566546011319 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 566546011320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546011321 putative substrate translocation pore; other site 566546011322 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 566546011323 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 566546011324 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 566546011325 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 566546011326 Coenzyme A binding pocket [chemical binding]; other site 566546011327 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 566546011328 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 566546011329 molybdopterin cofactor binding site [chemical binding]; other site 566546011330 substrate binding site [chemical binding]; other site 566546011331 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 566546011332 molybdopterin cofactor binding site; other site 566546011333 putative outer membrane lipoprotein; Provisional; Region: PRK10510 566546011334 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 566546011335 ligand binding site [chemical binding]; other site 566546011336 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 566546011337 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 566546011338 dimerization interface [polypeptide binding]; other site 566546011339 ligand binding site [chemical binding]; other site 566546011340 NADP binding site [chemical binding]; other site 566546011341 catalytic site [active] 566546011342 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 566546011343 Predicted transcriptional regulator [Transcription]; Region: COG2944 566546011344 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 566546011345 non-specific DNA binding site [nucleotide binding]; other site 566546011346 salt bridge; other site 566546011347 sequence-specific DNA binding site [nucleotide binding]; other site 566546011348 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 566546011349 DNA-binding site [nucleotide binding]; DNA binding site 566546011350 RNA-binding motif; other site 566546011351 small toxic polypeptide; Provisional; Region: PRK09759 566546011352 putative transposase OrfB; Reviewed; Region: PHA02517 566546011353 HTH-like domain; Region: HTH_21; pfam13276 566546011354 Integrase core domain; Region: rve; pfam00665 566546011355 Integrase core domain; Region: rve_2; pfam13333 566546011356 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 566546011357 Helix-turn-helix domain; Region: HTH_28; pfam13518 566546011358 Helix-turn-helix domain; Region: HTH_28; pfam13518 566546011359 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 566546011360 DALR anticodon binding domain; Region: DALR_1; pfam05746 566546011361 anticodon binding site; other site 566546011362 tRNA binding surface [nucleotide binding]; other site 566546011363 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 566546011364 dimer interface [polypeptide binding]; other site 566546011365 motif 1; other site 566546011366 active site 566546011367 motif 2; other site 566546011368 motif 3; other site 566546011369 YsaB-like lipoprotein; Region: YsaB; pfam13983 566546011370 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 566546011371 Acyltransferase family; Region: Acyl_transf_3; pfam01757 566546011372 hypothetical protein; Provisional; Region: PRK11383 566546011373 yiaA/B two helix domain; Region: YiaAB; pfam05360 566546011374 yiaA/B two helix domain; Region: YiaAB; pfam05360 566546011375 hypothetical protein; Provisional; Region: PRK11403 566546011376 yiaA/B two helix domain; Region: YiaAB; pfam05360 566546011377 xylulokinase; Provisional; Region: PRK15027 566546011378 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 566546011379 N- and C-terminal domain interface [polypeptide binding]; other site 566546011380 active site 566546011381 MgATP binding site [chemical binding]; other site 566546011382 catalytic site [active] 566546011383 metal binding site [ion binding]; metal-binding site 566546011384 xylulose binding site [chemical binding]; other site 566546011385 homodimer interface [polypeptide binding]; other site 566546011386 xylose isomerase; Provisional; Region: PRK05474 566546011387 xylose isomerase; Region: xylose_isom_A; TIGR02630 566546011388 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 566546011389 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 566546011390 putative ligand binding site [chemical binding]; other site 566546011391 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 566546011392 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 566546011393 Walker A/P-loop; other site 566546011394 ATP binding site [chemical binding]; other site 566546011395 Q-loop/lid; other site 566546011396 ABC transporter signature motif; other site 566546011397 Walker B; other site 566546011398 D-loop; other site 566546011399 H-loop/switch region; other site 566546011400 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 566546011401 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 566546011402 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 566546011403 TM-ABC transporter signature motif; other site 566546011404 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 566546011405 putative dimerization interface [polypeptide binding]; other site 566546011406 Transcriptional regulators [Transcription]; Region: PurR; COG1609 566546011407 putative ligand binding site [chemical binding]; other site 566546011408 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546011409 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 566546011410 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546011411 hypothetical protein; Provisional; Region: PRK10356 566546011412 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 566546011413 alpha-amylase; Reviewed; Region: malS; PRK09505 566546011414 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 566546011415 active site 566546011416 catalytic site [active] 566546011417 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 566546011418 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 566546011419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546011420 homodimer interface [polypeptide binding]; other site 566546011421 catalytic residue [active] 566546011422 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 566546011423 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 566546011424 Transcriptional regulator [Transcription]; Region: IclR; COG1414 566546011425 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 566546011426 Bacterial transcriptional regulator; Region: IclR; pfam01614 566546011427 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 566546011428 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 566546011429 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 566546011430 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 566546011431 DctM-like transporters; Region: DctM; pfam06808 566546011432 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 566546011433 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 566546011434 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 566546011435 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 566546011436 putative N- and C-terminal domain interface [polypeptide binding]; other site 566546011437 putative active site [active] 566546011438 MgATP binding site [chemical binding]; other site 566546011439 catalytic site [active] 566546011440 metal binding site [ion binding]; metal-binding site 566546011441 putative xylulose binding site [chemical binding]; other site 566546011442 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 566546011443 active site 566546011444 dimer interface [polypeptide binding]; other site 566546011445 magnesium binding site [ion binding]; other site 566546011446 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 566546011447 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 566546011448 AP (apurinic/apyrimidinic) site pocket; other site 566546011449 DNA interaction; other site 566546011450 Metal-binding active site; metal-binding site 566546011451 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 566546011452 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 566546011453 intersubunit interface [polypeptide binding]; other site 566546011454 active site 566546011455 Zn2+ binding site [ion binding]; other site 566546011456 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 566546011457 Transcriptional regulator [Transcription]; Region: LysR; COG0583 566546011458 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546011459 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 566546011460 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 566546011461 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 566546011462 HlyD family secretion protein; Region: HlyD_3; pfam13437 566546011463 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 566546011464 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 566546011465 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 566546011466 NAD(P) binding site [chemical binding]; other site 566546011467 catalytic residues [active] 566546011468 putative alcohol dehydrogenase; Provisional; Region: PRK09860 566546011469 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 566546011470 dimer interface [polypeptide binding]; other site 566546011471 active site 566546011472 metal binding site [ion binding]; metal-binding site 566546011473 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 566546011474 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 566546011475 G1 box; other site 566546011476 putative GEF interaction site [polypeptide binding]; other site 566546011477 GTP/Mg2+ binding site [chemical binding]; other site 566546011478 Switch I region; other site 566546011479 G2 box; other site 566546011480 G3 box; other site 566546011481 Switch II region; other site 566546011482 G4 box; other site 566546011483 G5 box; other site 566546011484 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 566546011485 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 566546011486 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 566546011487 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 566546011488 selenocysteine synthase; Provisional; Region: PRK04311 566546011489 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 566546011490 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 566546011491 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 566546011492 catalytic residue [active] 566546011493 putative glutathione S-transferase; Provisional; Region: PRK10357 566546011494 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 566546011495 putative C-terminal domain interface [polypeptide binding]; other site 566546011496 putative GSH binding site (G-site) [chemical binding]; other site 566546011497 putative dimer interface [polypeptide binding]; other site 566546011498 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 566546011499 dimer interface [polypeptide binding]; other site 566546011500 N-terminal domain interface [polypeptide binding]; other site 566546011501 putative substrate binding pocket (H-site) [chemical binding]; other site 566546011502 PAAR motif; Region: PAAR_motif; cl15808 566546011503 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 566546011504 RHS Repeat; Region: RHS_repeat; pfam05593 566546011505 RHS Repeat; Region: RHS_repeat; pfam05593 566546011506 RHS Repeat; Region: RHS_repeat; cl11982 566546011507 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 566546011508 RHS Repeat; Region: RHS_repeat; pfam05593 566546011509 RHS Repeat; Region: RHS_repeat; pfam05593 566546011510 RHS protein; Region: RHS; pfam03527 566546011511 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 566546011512 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 566546011513 putative lyase; Provisional; Region: PRK09687 566546011514 pseudogene, putative rhs C-terminal tip 566546011515 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 566546011516 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 566546011517 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 566546011518 HlyD family secretion protein; Region: HlyD_3; pfam13437 566546011519 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 566546011520 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 566546011521 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 566546011522 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 566546011523 active site 566546011524 P-loop; other site 566546011525 phosphorylation site [posttranslational modification] 566546011526 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 566546011527 active site 566546011528 phosphorylation site [posttranslational modification] 566546011529 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 566546011530 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 566546011531 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 566546011532 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 566546011533 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 566546011534 hypothetical protein; Provisional; Region: PRK11020 566546011535 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 566546011536 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 566546011537 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 566546011538 trimer interface [polypeptide binding]; other site 566546011539 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 566546011540 trimer interface [polypeptide binding]; other site 566546011541 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 566546011542 Haemagglutinin; Region: HIM; pfam05662 566546011543 Haemagglutinin; Region: HIM; pfam05662 566546011544 YadA-like C-terminal region; Region: YadA; pfam03895 566546011545 L-lactate permease; Provisional; Region: PRK10420 566546011546 glycolate transporter; Provisional; Region: PRK09695 566546011547 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 566546011548 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 566546011549 DNA-binding site [nucleotide binding]; DNA binding site 566546011550 FCD domain; Region: FCD; pfam07729 566546011551 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 566546011552 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 566546011553 phosphate binding site [ion binding]; other site 566546011554 putative rRNA methylase; Provisional; Region: PRK10358 566546011555 serine acetyltransferase; Provisional; Region: cysE; PRK11132 566546011556 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 566546011557 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 566546011558 trimer interface [polypeptide binding]; other site 566546011559 active site 566546011560 substrate binding site [chemical binding]; other site 566546011561 CoA binding site [chemical binding]; other site 566546011562 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 566546011563 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 566546011564 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 566546011565 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 566546011566 SecA binding site; other site 566546011567 Preprotein binding site; other site 566546011568 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 566546011569 GSH binding site [chemical binding]; other site 566546011570 catalytic residues [active] 566546011571 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 566546011572 active site residue [active] 566546011573 phosphoglyceromutase; Provisional; Region: PRK05434 566546011574 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 566546011575 AmiB activator; Provisional; Region: PRK11637 566546011576 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 566546011577 Peptidase family M23; Region: Peptidase_M23; pfam01551 566546011578 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 566546011579 NodB motif; other site 566546011580 putative active site [active] 566546011581 putative catalytic site [active] 566546011582 Zn binding site [ion binding]; other site 566546011583 putative glycosyl transferase; Provisional; Region: PRK10073 566546011584 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 566546011585 active site 566546011586 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 566546011587 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 566546011588 NAD(P) binding site [chemical binding]; other site 566546011589 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 566546011590 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 566546011591 substrate-cofactor binding pocket; other site 566546011592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546011593 catalytic residue [active] 566546011594 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 566546011595 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 566546011596 NADP binding site [chemical binding]; other site 566546011597 homopentamer interface [polypeptide binding]; other site 566546011598 substrate binding site [chemical binding]; other site 566546011599 active site 566546011600 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 566546011601 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 566546011602 putative active site [active] 566546011603 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 566546011604 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 566546011605 putative active site [active] 566546011606 O-Antigen ligase; Region: Wzy_C; pfam04932 566546011607 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 566546011608 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 566546011609 active site 566546011610 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 566546011611 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 566546011612 Ligand binding site; other site 566546011613 metal-binding site 566546011614 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 566546011615 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 566546011616 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 566546011617 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 566546011618 Ligand binding site; other site 566546011619 metal-binding site 566546011620 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 566546011621 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 566546011622 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 566546011623 Ligand binding site; other site 566546011624 metal-binding site 566546011625 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 566546011626 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 566546011627 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 566546011628 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 566546011629 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 566546011630 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 566546011631 putative active site [active] 566546011632 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 566546011633 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 566546011634 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 566546011635 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 566546011636 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 566546011637 active site 566546011638 (T/H)XGH motif; other site 566546011639 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 566546011640 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 566546011641 DNA binding site [nucleotide binding] 566546011642 catalytic residue [active] 566546011643 H2TH interface [polypeptide binding]; other site 566546011644 putative catalytic residues [active] 566546011645 turnover-facilitating residue; other site 566546011646 intercalation triad [nucleotide binding]; other site 566546011647 8OG recognition residue [nucleotide binding]; other site 566546011648 putative reading head residues; other site 566546011649 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 566546011650 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 566546011651 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 566546011652 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 566546011653 hypothetical protein; Reviewed; Region: PRK00024 566546011654 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 566546011655 MPN+ (JAMM) motif; other site 566546011656 Zinc-binding site [ion binding]; other site 566546011657 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 566546011658 Flavoprotein; Region: Flavoprotein; pfam02441 566546011659 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 566546011660 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 566546011661 trimer interface [polypeptide binding]; other site 566546011662 active site 566546011663 division inhibitor protein; Provisional; Region: slmA; PRK09480 566546011664 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 566546011665 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 566546011666 active site 566546011667 ribonuclease PH; Reviewed; Region: rph; PRK00173 566546011668 Ribonuclease PH; Region: RNase_PH_bact; cd11362 566546011669 hexamer interface [polypeptide binding]; other site 566546011670 active site 566546011671 hypothetical protein; Provisional; Region: PRK11820 566546011672 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 566546011673 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 566546011674 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 566546011675 BRO family, N-terminal domain; Region: Bro-N; pfam02498 566546011676 Predicted membrane protein [Function unknown]; Region: COG2860 566546011677 UPF0126 domain; Region: UPF0126; pfam03458 566546011678 UPF0126 domain; Region: UPF0126; pfam03458 566546011679 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 566546011680 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 566546011681 nucleotide binding pocket [chemical binding]; other site 566546011682 K-X-D-G motif; other site 566546011683 catalytic site [active] 566546011684 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 566546011685 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 566546011686 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 566546011687 catalytic site [active] 566546011688 G-X2-G-X-G-K; other site 566546011689 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 566546011690 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 566546011691 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 566546011692 Zn2+ binding site [ion binding]; other site 566546011693 Mg2+ binding site [ion binding]; other site 566546011694 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 566546011695 synthetase active site [active] 566546011696 NTP binding site [chemical binding]; other site 566546011697 metal binding site [ion binding]; metal-binding site 566546011698 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 566546011699 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 566546011700 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 566546011701 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 566546011702 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 566546011703 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 566546011704 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 566546011705 generic binding surface II; other site 566546011706 ssDNA binding site; other site 566546011707 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 566546011708 ATP binding site [chemical binding]; other site 566546011709 putative Mg++ binding site [ion binding]; other site 566546011710 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 566546011711 nucleotide binding region [chemical binding]; other site 566546011712 ATP-binding site [chemical binding]; other site 566546011713 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 566546011714 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 566546011715 AsmA family; Region: AsmA; pfam05170 566546011716 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 566546011717 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 566546011718 putative alpha-glucosidase; Provisional; Region: PRK10658 566546011719 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 566546011720 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 566546011721 active site 566546011722 homotrimer interface [polypeptide binding]; other site 566546011723 catalytic site [active] 566546011724 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 566546011725 putative transporter; Provisional; Region: PRK11462 566546011726 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 566546011727 integrase; Provisional; Region: PRK09692 566546011728 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 566546011729 active site 566546011730 Int/Topo IB signature motif; other site 566546011731 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 566546011732 Part of AAA domain; Region: AAA_19; pfam13245 566546011733 Family description; Region: UvrD_C_2; pfam13538 566546011734 AAA ATPase domain; Region: AAA_15; pfam13175 566546011735 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 566546011736 Walker A/P-loop; other site 566546011737 ATP binding site [chemical binding]; other site 566546011738 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 566546011739 putative active site [active] 566546011740 putative metal-binding site [ion binding]; other site 566546011741 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 566546011742 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 566546011743 putative transposase OrfB; Reviewed; Region: PHA02517 566546011744 HTH-like domain; Region: HTH_21; pfam13276 566546011745 Integrase core domain; Region: rve; pfam00665 566546011746 Integrase core domain; Region: rve_2; pfam13333 566546011747 Transposase; Region: HTH_Tnp_1; cl17663 566546011748 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 566546011749 Domain of unknown function (DUF932); Region: DUF932; pfam06067 566546011750 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 566546011751 MPN+ (JAMM) motif; other site 566546011752 Zinc-binding site [ion binding]; other site 566546011753 Protein of unknown function (DUF987); Region: DUF987; pfam06174 566546011754 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 566546011755 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 566546011756 pseudogene, hypothetical protein 566546011757 sugar efflux transporter; Region: 2A0120; TIGR00899 566546011758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546011759 putative substrate translocation pore; other site 566546011760 EamA-like transporter family; Region: EamA; pfam00892 566546011761 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 566546011762 EamA-like transporter family; Region: EamA; pfam00892 566546011763 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 566546011764 lipoprotein, YaeC family; Region: TIGR00363 566546011765 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 566546011766 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 566546011767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546011768 putative substrate translocation pore; other site 566546011769 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 566546011770 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 566546011771 cryptic adenine deaminase; Provisional; Region: PRK10027 566546011772 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 566546011773 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 566546011774 active site 566546011775 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 566546011776 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 566546011777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546011778 putative substrate translocation pore; other site 566546011779 regulatory protein UhpC; Provisional; Region: PRK11663 566546011780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546011781 putative substrate translocation pore; other site 566546011782 sensory histidine kinase UhpB; Provisional; Region: PRK11644 566546011783 MASE1; Region: MASE1; pfam05231 566546011784 Histidine kinase; Region: HisKA_3; pfam07730 566546011785 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 566546011786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546011787 active site 566546011788 phosphorylation site [posttranslational modification] 566546011789 intermolecular recognition site; other site 566546011790 dimerization interface [polypeptide binding]; other site 566546011791 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 566546011792 DNA binding residues [nucleotide binding] 566546011793 dimerization interface [polypeptide binding]; other site 566546011794 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 566546011795 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 566546011796 putative valine binding site [chemical binding]; other site 566546011797 dimer interface [polypeptide binding]; other site 566546011798 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 566546011799 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 566546011800 PYR/PP interface [polypeptide binding]; other site 566546011801 dimer interface [polypeptide binding]; other site 566546011802 TPP binding site [chemical binding]; other site 566546011803 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 566546011804 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 566546011805 TPP-binding site [chemical binding]; other site 566546011806 dimer interface [polypeptide binding]; other site 566546011807 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 566546011808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546011809 putative substrate translocation pore; other site 566546011810 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 566546011811 Domain of unknown function (DUF202); Region: DUF202; pfam02656 566546011812 Predicted membrane protein [Function unknown]; Region: COG2149 566546011813 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 566546011814 Sulfatase; Region: Sulfatase; pfam00884 566546011815 putative transporter; Provisional; Region: PRK10484 566546011816 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 566546011817 Na binding site [ion binding]; other site 566546011818 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 566546011819 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546011820 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 566546011821 pseudogene, conserved hypothetical protein 566546011822 pseudogene, PTS system, alpha-glucoside-specific IIBC subunit 566546011823 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 566546011824 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 566546011825 DNA-binding site [nucleotide binding]; DNA binding site 566546011826 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 566546011827 putative transporter; Validated; Region: PRK03818 566546011828 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 566546011829 TrkA-C domain; Region: TrkA_C; pfam02080 566546011830 TrkA-C domain; Region: TrkA_C; pfam02080 566546011831 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 566546011832 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 566546011833 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 566546011834 putative dimer interface [polypeptide binding]; other site 566546011835 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 566546011836 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 566546011837 putative dimer interface [polypeptide binding]; other site 566546011838 hypothetical protein; Provisional; Region: PRK11616 566546011839 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 566546011840 putative oxidoreductase; Provisional; Region: PRK11445 566546011841 hypothetical protein; Provisional; Region: PRK07236 566546011842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546011843 D-galactonate transporter; Region: 2A0114; TIGR00893 566546011844 putative substrate translocation pore; other site 566546011845 galactonate dehydratase; Provisional; Region: PRK14017 566546011846 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 566546011847 putative active site pocket [active] 566546011848 putative metal binding site [ion binding]; other site 566546011849 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 566546011850 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 566546011851 active site 566546011852 intersubunit interface [polypeptide binding]; other site 566546011853 catalytic residue [active] 566546011854 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 566546011855 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 566546011856 Transcriptional regulators [Transcription]; Region: FadR; COG2186 566546011857 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 566546011858 DNA-binding site [nucleotide binding]; DNA binding site 566546011859 FCD domain; Region: FCD; pfam07729 566546011860 hypothetical protein; Provisional; Region: PRK10215 566546011861 sugar phosphate phosphatase; Provisional; Region: PRK10513 566546011862 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 566546011863 active site 566546011864 motif I; other site 566546011865 motif II; other site 566546011866 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 566546011867 hypothetical protein; Provisional; Region: PRK11426 566546011868 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 566546011869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546011870 Mg2+ binding site [ion binding]; other site 566546011871 G-X-G motif; other site 566546011872 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 566546011873 anchoring element; other site 566546011874 dimer interface [polypeptide binding]; other site 566546011875 ATP binding site [chemical binding]; other site 566546011876 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 566546011877 active site 566546011878 putative metal-binding site [ion binding]; other site 566546011879 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 566546011880 recF protein; Region: recf; TIGR00611 566546011881 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 566546011882 Walker A/P-loop; other site 566546011883 ATP binding site [chemical binding]; other site 566546011884 Q-loop/lid; other site 566546011885 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 566546011886 ABC transporter signature motif; other site 566546011887 Walker B; other site 566546011888 D-loop; other site 566546011889 H-loop/switch region; other site 566546011890 DNA polymerase III subunit beta; Validated; Region: PRK05643 566546011891 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 566546011892 putative DNA binding surface [nucleotide binding]; other site 566546011893 dimer interface [polypeptide binding]; other site 566546011894 beta-clamp/clamp loader binding surface; other site 566546011895 beta-clamp/translesion DNA polymerase binding surface; other site 566546011896 DnaA N-terminal domain; Region: DnaA_N; pfam11638 566546011897 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 566546011898 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546011899 Walker A motif; other site 566546011900 ATP binding site [chemical binding]; other site 566546011901 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 566546011902 Walker B motif; other site 566546011903 arginine finger; other site 566546011904 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 566546011905 DnaA box-binding interface [nucleotide binding]; other site 566546011906 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 566546011907 ribonuclease P; Reviewed; Region: rnpA; PRK01732 566546011908 membrane protein insertase; Provisional; Region: PRK01318 566546011909 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 566546011910 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 566546011911 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 566546011912 trmE is a tRNA modification GTPase; Region: trmE; cd04164 566546011913 G1 box; other site 566546011914 GTP/Mg2+ binding site [chemical binding]; other site 566546011915 Switch I region; other site 566546011916 G2 box; other site 566546011917 Switch II region; other site 566546011918 G3 box; other site 566546011919 G4 box; other site 566546011920 G5 box; other site 566546011921 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 566546011922 Tryptophanese operon leader peptide; Region: Tna_leader; pfam08053 566546011923 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 566546011924 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 566546011925 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 566546011926 catalytic residue [active] 566546011927 tryptophan permease TnaB; Provisional; Region: PRK09664 566546011928 aromatic amino acid transport protein; Region: araaP; TIGR00837 566546011929 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 566546011930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546011931 putative substrate translocation pore; other site 566546011932 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 566546011933 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546011934 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 566546011935 substrate binding pocket [chemical binding]; other site 566546011936 dimerization interface [polypeptide binding]; other site 566546011937 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 566546011938 Predicted flavoprotein [General function prediction only]; Region: COG0431 566546011939 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 566546011940 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 566546011941 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 566546011942 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 566546011943 active site 566546011944 motif I; other site 566546011945 motif II; other site 566546011946 putative inner membrane protein; Provisional; Region: PRK09823 566546011947 Uncharacterized protein family (UPF0167); Region: UPF0167; cl01252 566546011948 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 566546011949 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 566546011950 active site 566546011951 trimer interface [polypeptide binding]; other site 566546011952 allosteric site; other site 566546011953 active site lid [active] 566546011954 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 566546011955 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 566546011956 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 566546011957 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 566546011958 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 566546011959 trimer interface; other site 566546011960 sugar binding site [chemical binding]; other site 566546011961 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 566546011962 beta-galactosidase; Region: BGL; TIGR03356 566546011963 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 566546011964 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 566546011965 active site turn [active] 566546011966 phosphorylation site [posttranslational modification] 566546011967 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 566546011968 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 566546011969 HPr interaction site; other site 566546011970 glycerol kinase (GK) interaction site [polypeptide binding]; other site 566546011971 active site 566546011972 phosphorylation site [posttranslational modification] 566546011973 transcriptional antiterminator BglG; Provisional; Region: PRK09772 566546011974 CAT RNA binding domain; Region: CAT_RBD; pfam03123 566546011975 PRD domain; Region: PRD; pfam00874 566546011976 PRD domain; Region: PRD; pfam00874 566546011977 transcriptional regulator PhoU; Provisional; Region: PRK11115 566546011978 PhoU domain; Region: PhoU; pfam01895 566546011979 PhoU domain; Region: PhoU; pfam01895 566546011980 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 566546011981 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 566546011982 Walker A/P-loop; other site 566546011983 ATP binding site [chemical binding]; other site 566546011984 Q-loop/lid; other site 566546011985 ABC transporter signature motif; other site 566546011986 Walker B; other site 566546011987 D-loop; other site 566546011988 H-loop/switch region; other site 566546011989 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 566546011990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546011991 dimer interface [polypeptide binding]; other site 566546011992 conserved gate region; other site 566546011993 putative PBP binding loops; other site 566546011994 ABC-ATPase subunit interface; other site 566546011995 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 566546011996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546011997 dimer interface [polypeptide binding]; other site 566546011998 conserved gate region; other site 566546011999 putative PBP binding loops; other site 566546012000 ABC-ATPase subunit interface; other site 566546012001 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 566546012002 Fimbrial protein; Region: Fimbrial; cl01416 566546012003 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 566546012004 PapC N-terminal domain; Region: PapC_N; pfam13954 566546012005 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 566546012006 PapC C-terminal domain; Region: PapC_C; pfam13953 566546012007 fimbrial chaperone protein; Provisional; Region: lfpB; PRK15290 566546012008 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 566546012009 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 566546012010 fimbrial protein; Provisional; Region: lpfA; PRK15289 566546012011 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 566546012012 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 566546012013 glutaminase active site [active] 566546012014 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 566546012015 dimer interface [polypeptide binding]; other site 566546012016 active site 566546012017 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 566546012018 dimer interface [polypeptide binding]; other site 566546012019 active site 566546012020 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 566546012021 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 566546012022 Substrate binding site; other site 566546012023 Mg++ binding site; other site 566546012024 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 566546012025 active site 566546012026 substrate binding site [chemical binding]; other site 566546012027 CoA binding site [chemical binding]; other site 566546012028 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 566546012029 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 566546012030 gamma subunit interface [polypeptide binding]; other site 566546012031 epsilon subunit interface [polypeptide binding]; other site 566546012032 LBP interface [polypeptide binding]; other site 566546012033 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 566546012034 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 566546012035 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 566546012036 alpha subunit interaction interface [polypeptide binding]; other site 566546012037 Walker A motif; other site 566546012038 ATP binding site [chemical binding]; other site 566546012039 Walker B motif; other site 566546012040 inhibitor binding site; inhibition site 566546012041 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 566546012042 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 566546012043 core domain interface [polypeptide binding]; other site 566546012044 delta subunit interface [polypeptide binding]; other site 566546012045 epsilon subunit interface [polypeptide binding]; other site 566546012046 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 566546012047 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 566546012048 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 566546012049 beta subunit interaction interface [polypeptide binding]; other site 566546012050 Walker A motif; other site 566546012051 ATP binding site [chemical binding]; other site 566546012052 Walker B motif; other site 566546012053 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 566546012054 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 566546012055 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 566546012056 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 566546012057 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 566546012058 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 566546012059 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 566546012060 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 566546012061 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 566546012062 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 566546012063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546012064 S-adenosylmethionine binding site [chemical binding]; other site 566546012065 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 566546012066 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 566546012067 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 566546012068 FMN-binding protein MioC; Provisional; Region: PRK09004 566546012069 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 566546012070 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 566546012071 putative DNA binding site [nucleotide binding]; other site 566546012072 putative Zn2+ binding site [ion binding]; other site 566546012073 AsnC family; Region: AsnC_trans_reg; pfam01037 566546012074 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 566546012075 dimer interface [polypeptide binding]; other site 566546012076 active site 566546012077 hypothetical protein; Provisional; Region: yieM; PRK10997 566546012078 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 566546012079 metal ion-dependent adhesion site (MIDAS); other site 566546012080 regulatory ATPase RavA; Provisional; Region: PRK13531 566546012081 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546012082 Walker A motif; other site 566546012083 ATP binding site [chemical binding]; other site 566546012084 Walker B motif; other site 566546012085 arginine finger; other site 566546012086 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 566546012087 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 566546012088 potassium uptake protein; Region: kup; TIGR00794 566546012089 D-ribose pyranase; Provisional; Region: PRK11797 566546012090 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 566546012091 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 566546012092 Walker A/P-loop; other site 566546012093 ATP binding site [chemical binding]; other site 566546012094 Q-loop/lid; other site 566546012095 ABC transporter signature motif; other site 566546012096 Walker B; other site 566546012097 D-loop; other site 566546012098 H-loop/switch region; other site 566546012099 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 566546012100 pseudogene, Truncated D-ribose transporter subunit 566546012101 pseudogene, Truncated DNA-binding transcriptional repressor of ribose metabolism 566546012102 putative transporter; Provisional; Region: PRK10504 566546012103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546012104 putative substrate translocation pore; other site 566546012105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546012106 Transcriptional regulators [Transcription]; Region: FadR; COG2186 566546012107 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 566546012108 DNA-binding site [nucleotide binding]; DNA binding site 566546012109 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 566546012110 transcriptional regulator HdfR; Provisional; Region: PRK03601 566546012111 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546012112 LysR substrate binding domain; Region: LysR_substrate; pfam03466 566546012113 dimerization interface [polypeptide binding]; other site 566546012114 hypothetical protein; Provisional; Region: PRK11027 566546012115 putative ATP-dependent protease; Provisional; Region: PRK09862 566546012116 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 566546012117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546012118 Walker A motif; other site 566546012119 ATP binding site [chemical binding]; other site 566546012120 Walker B motif; other site 566546012121 arginine finger; other site 566546012122 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 566546012123 ilvG operon leader peptide; Provisional; Region: PRK10424 566546012124 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 566546012125 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 566546012126 PYR/PP interface [polypeptide binding]; other site 566546012127 dimer interface [polypeptide binding]; other site 566546012128 TPP binding site [chemical binding]; other site 566546012129 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 566546012130 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 566546012131 TPP-binding site [chemical binding]; other site 566546012132 dimer interface [polypeptide binding]; other site 566546012133 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 566546012134 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 566546012135 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 566546012136 homodimer interface [polypeptide binding]; other site 566546012137 substrate-cofactor binding pocket; other site 566546012138 catalytic residue [active] 566546012139 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 566546012140 threonine dehydratase; Reviewed; Region: PRK09224 566546012141 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 566546012142 tetramer interface [polypeptide binding]; other site 566546012143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546012144 catalytic residue [active] 566546012145 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 566546012146 putative Ile/Val binding site [chemical binding]; other site 566546012147 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 566546012148 putative Ile/Val binding site [chemical binding]; other site 566546012149 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546012150 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 566546012151 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 566546012152 putative dimerization interface [polypeptide binding]; other site 566546012153 ketol-acid reductoisomerase; Validated; Region: PRK05225 566546012154 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 566546012155 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 566546012156 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 566546012157 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 566546012158 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 566546012159 pseudogene, conserved protein 566546012160 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 566546012161 Part of AAA domain; Region: AAA_19; pfam13245 566546012162 Family description; Region: UvrD_C_2; pfam13538 566546012163 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 566546012164 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 566546012165 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 566546012166 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 566546012167 ATP binding site [chemical binding]; other site 566546012168 Mg++ binding site [ion binding]; other site 566546012169 motif III; other site 566546012170 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 566546012171 nucleotide binding region [chemical binding]; other site 566546012172 ATP-binding site [chemical binding]; other site 566546012173 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 566546012174 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 566546012175 catalytic residues [active] 566546012176 transcription termination factor Rho; Provisional; Region: rho; PRK09376 566546012177 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 566546012178 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 566546012179 RNA binding site [nucleotide binding]; other site 566546012180 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 566546012181 multimer interface [polypeptide binding]; other site 566546012182 Walker A motif; other site 566546012183 ATP binding site [chemical binding]; other site 566546012184 Walker B motif; other site 566546012185 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 566546012186 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 566546012187 Mg++ binding site [ion binding]; other site 566546012188 putative catalytic motif [active] 566546012189 substrate binding site [chemical binding]; other site 566546012190 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 566546012191 Chain length determinant protein; Region: Wzz; pfam02706 566546012192 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 566546012193 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 566546012194 active site 566546012195 homodimer interface [polypeptide binding]; other site 566546012196 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 566546012197 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 566546012198 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 566546012199 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 566546012200 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 566546012201 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 566546012202 NAD binding site [chemical binding]; other site 566546012203 substrate binding site [chemical binding]; other site 566546012204 homodimer interface [polypeptide binding]; other site 566546012205 active site 566546012206 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 566546012207 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 566546012208 substrate binding site; other site 566546012209 tetramer interface; other site 566546012210 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 566546012211 Coenzyme A binding pocket [chemical binding]; other site 566546012212 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 566546012213 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 566546012214 inhibitor-cofactor binding pocket; inhibition site 566546012215 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546012216 catalytic residue [active] 566546012217 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 566546012218 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 566546012219 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 566546012220 putative common antigen polymerase; Provisional; Region: PRK02975 566546012221 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 566546012222 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 566546012223 putative transport protein YifK; Provisional; Region: PRK10746 566546012224 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 566546012225 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 566546012226 FeS/SAM binding site; other site 566546012227 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 566546012228 pseudogene, hypothetical protein 566546012229 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 566546012230 HemY protein N-terminus; Region: HemY_N; pfam07219 566546012231 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 566546012232 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 566546012233 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 566546012234 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 566546012235 active site 566546012236 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 566546012237 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 566546012238 domain interfaces; other site 566546012239 active site 566546012240 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 566546012241 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 566546012242 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 566546012243 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 566546012244 putative iron binding site [ion binding]; other site 566546012245 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 566546012246 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 566546012247 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 566546012248 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 566546012249 hypothetical protein; Provisional; Region: PRK10963 566546012250 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 566546012251 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 566546012252 active site 566546012253 DNA binding site [nucleotide binding] 566546012254 Int/Topo IB signature motif; other site 566546012255 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 566546012256 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 566546012257 motif II; other site 566546012258 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 566546012259 Part of AAA domain; Region: AAA_19; pfam13245 566546012260 Family description; Region: UvrD_C_2; pfam13538 566546012261 Predicted periplasmic protein [Function unknown]; Region: COG3698 566546012262 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 566546012263 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 566546012264 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 566546012265 Cl binding site [ion binding]; other site 566546012266 oligomer interface [polypeptide binding]; other site 566546012267 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 566546012268 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 566546012269 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 566546012270 EamA-like transporter family; Region: EamA; cl17759 566546012271 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 566546012272 CoenzymeA binding site [chemical binding]; other site 566546012273 subunit interaction site [polypeptide binding]; other site 566546012274 PHB binding site; other site 566546012275 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 566546012276 dimerization interface [polypeptide binding]; other site 566546012277 substrate binding site [chemical binding]; other site 566546012278 active site 566546012279 calcium binding site [ion binding]; other site 566546012280 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 566546012281 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 566546012282 ATP binding site [chemical binding]; other site 566546012283 putative Mg++ binding site [ion binding]; other site 566546012284 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 566546012285 nucleotide binding region [chemical binding]; other site 566546012286 ATP-binding site [chemical binding]; other site 566546012287 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 566546012288 Helicase and RNase D C-terminal; Region: HRDC; smart00341 566546012289 threonine efflux system; Provisional; Region: PRK10229 566546012290 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 566546012291 lysophospholipase L2; Provisional; Region: PRK10749 566546012292 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 566546012293 putative hydrolase; Provisional; Region: PRK10976 566546012294 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 566546012295 active site 566546012296 motif I; other site 566546012297 motif II; other site 566546012298 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 566546012299 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 566546012300 EamA-like transporter family; Region: EamA; pfam00892 566546012301 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 566546012302 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546012303 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 566546012304 putative dimerization interface [polypeptide binding]; other site 566546012305 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 566546012306 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 566546012307 THF binding site; other site 566546012308 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 566546012309 substrate binding site [chemical binding]; other site 566546012310 THF binding site; other site 566546012311 zinc-binding site [ion binding]; other site 566546012312 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 566546012313 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 566546012314 uridine phosphorylase; Provisional; Region: PRK11178 566546012315 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 566546012316 DNA recombination protein RmuC; Provisional; Region: PRK10361 566546012317 RmuC family; Region: RmuC; pfam02646 566546012318 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 566546012319 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546012320 S-adenosylmethionine binding site [chemical binding]; other site 566546012321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 566546012322 SCP-2 sterol transfer family; Region: SCP2; pfam02036 566546012323 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 566546012324 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 566546012325 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 566546012326 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 566546012327 sec-independent translocase; Provisional; Region: PRK01770 566546012328 sec-independent translocase; Provisional; Region: tatB; PRK00404 566546012329 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 566546012330 pseudogene, DNase, magnesium-dependent 566546012331 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 566546012332 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 566546012333 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 566546012334 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 566546012335 FMN reductase; Validated; Region: fre; PRK08051 566546012336 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 566546012337 FAD binding pocket [chemical binding]; other site 566546012338 FAD binding motif [chemical binding]; other site 566546012339 phosphate binding motif [ion binding]; other site 566546012340 beta-alpha-beta structure motif; other site 566546012341 NAD binding pocket [chemical binding]; other site 566546012342 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 566546012343 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 566546012344 dimer interface [polypeptide binding]; other site 566546012345 active site 566546012346 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 566546012347 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 566546012348 substrate binding site [chemical binding]; other site 566546012349 oxyanion hole (OAH) forming residues; other site 566546012350 trimer interface [polypeptide binding]; other site 566546012351 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 566546012352 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 566546012353 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 566546012354 proline dipeptidase; Provisional; Region: PRK13607 566546012355 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 566546012356 active site 566546012357 hypothetical protein; Provisional; Region: PRK11568 566546012358 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 566546012359 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 566546012360 potassium transporter; Provisional; Region: PRK10750 566546012361 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 566546012362 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 566546012363 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 566546012364 Walker A motif; other site 566546012365 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 566546012366 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 566546012367 GTP binding site; other site 566546012368 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 566546012369 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 566546012370 serine/threonine protein kinase; Provisional; Region: PRK11768 566546012371 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 566546012372 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 566546012373 catalytic residues [active] 566546012374 hinge region; other site 566546012375 alpha helical domain; other site 566546012376 hypothetical protein; Provisional; Region: PRK11367 566546012377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 566546012378 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 566546012379 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 566546012380 putative acyl-acceptor binding pocket; other site 566546012381 DNA polymerase I; Provisional; Region: PRK05755 566546012382 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 566546012383 active site 566546012384 metal binding site 1 [ion binding]; metal-binding site 566546012385 putative 5' ssDNA interaction site; other site 566546012386 metal binding site 3; metal-binding site 566546012387 metal binding site 2 [ion binding]; metal-binding site 566546012388 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 566546012389 putative DNA binding site [nucleotide binding]; other site 566546012390 putative metal binding site [ion binding]; other site 566546012391 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 566546012392 active site 566546012393 catalytic site [active] 566546012394 substrate binding site [chemical binding]; other site 566546012395 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 566546012396 active site 566546012397 DNA binding site [nucleotide binding] 566546012398 catalytic site [active] 566546012399 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 566546012400 G1 box; other site 566546012401 GTP/Mg2+ binding site [chemical binding]; other site 566546012402 Switch I region; other site 566546012403 G2 box; other site 566546012404 G3 box; other site 566546012405 Switch II region; other site 566546012406 G4 box; other site 566546012407 G5 box; other site 566546012408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 566546012409 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 566546012410 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 566546012411 FeS/SAM binding site; other site 566546012412 HemN C-terminal domain; Region: HemN_C; pfam06969 566546012413 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 566546012414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546012415 active site 566546012416 phosphorylation site [posttranslational modification] 566546012417 intermolecular recognition site; other site 566546012418 dimerization interface [polypeptide binding]; other site 566546012419 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546012420 Walker A motif; other site 566546012421 ATP binding site [chemical binding]; other site 566546012422 Walker B motif; other site 566546012423 arginine finger; other site 566546012424 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 566546012425 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 566546012426 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 566546012427 putative active site [active] 566546012428 heme pocket [chemical binding]; other site 566546012429 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 566546012430 dimer interface [polypeptide binding]; other site 566546012431 phosphorylation site [posttranslational modification] 566546012432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546012433 ATP binding site [chemical binding]; other site 566546012434 Mg2+ binding site [ion binding]; other site 566546012435 G-X-G motif; other site 566546012436 glutamine synthetase; Provisional; Region: glnA; PRK09469 566546012437 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 566546012438 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 566546012439 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 566546012440 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 566546012441 G1 box; other site 566546012442 putative GEF interaction site [polypeptide binding]; other site 566546012443 GTP/Mg2+ binding site [chemical binding]; other site 566546012444 Switch I region; other site 566546012445 G2 box; other site 566546012446 G3 box; other site 566546012447 Switch II region; other site 566546012448 G4 box; other site 566546012449 G5 box; other site 566546012450 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 566546012451 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 566546012452 transcriptional regulator protein; Region: phnR; TIGR03337 566546012453 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 566546012454 DNA-binding site [nucleotide binding]; DNA binding site 566546012455 UTRA domain; Region: UTRA; pfam07702 566546012456 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 566546012457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546012458 putative substrate translocation pore; other site 566546012459 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 566546012460 outer membrane porin L; Provisional; Region: ompL; PRK09980 566546012461 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 566546012462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546012463 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 566546012464 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 566546012465 alpha-glucosidase; Provisional; Region: PRK10426 566546012466 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 566546012467 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 566546012468 putative active site [active] 566546012469 putative catalytic site [active] 566546012470 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 566546012471 active site 566546012472 catalytic residues [active] 566546012473 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 566546012474 dimerization interface [polypeptide binding]; other site 566546012475 putative active cleft [active] 566546012476 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 566546012477 catalytic residue [active] 566546012478 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 566546012479 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 566546012480 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 566546012481 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 566546012482 substrate binding site [chemical binding]; other site 566546012483 ATP binding site [chemical binding]; other site 566546012484 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 566546012485 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 566546012486 putative DNA binding site [nucleotide binding]; other site 566546012487 putative Zn2+ binding site [ion binding]; other site 566546012488 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 566546012489 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 566546012490 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 566546012491 motif II; other site 566546012492 hypothetical protein; Reviewed; Region: PRK01637 566546012493 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 566546012494 putative active site [active] 566546012495 dimerization interface [polypeptide binding]; other site 566546012496 putative tRNAtyr binding site [nucleotide binding]; other site 566546012497 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 566546012498 Coenzyme A binding pocket [chemical binding]; other site 566546012499 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 566546012500 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 566546012501 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 566546012502 substrate binding pocket [chemical binding]; other site 566546012503 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 566546012504 non-specific DNA binding site [nucleotide binding]; other site 566546012505 salt bridge; other site 566546012506 sequence-specific DNA binding site [nucleotide binding]; other site 566546012507 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 566546012508 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 566546012509 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 566546012510 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 566546012511 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 566546012512 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 566546012513 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 566546012514 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 566546012515 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 566546012516 [4Fe-4S] binding site [ion binding]; other site 566546012517 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 566546012518 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 566546012519 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 566546012520 molybdopterin cofactor binding site; other site 566546012521 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 566546012522 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 566546012523 putative frv operon regulatory protein; Provisional; Region: PRK09863 566546012524 HTH domain; Region: HTH_11; pfam08279 566546012525 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 566546012526 active site 566546012527 phosphorylation site [posttranslational modification] 566546012528 putative peptidase; Provisional; Region: PRK09864 566546012529 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 566546012530 oligomer interface [polypeptide binding]; other site 566546012531 active site 566546012532 metal binding site [ion binding]; metal-binding site 566546012533 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 566546012534 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 566546012535 active site 566546012536 P-loop; other site 566546012537 phosphorylation site [posttranslational modification] 566546012538 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 566546012539 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 566546012540 active site 566546012541 phosphorylation site [posttranslational modification] 566546012542 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 566546012543 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 566546012544 intersubunit interface [polypeptide binding]; other site 566546012545 active site 566546012546 Zn2+ binding site [ion binding]; other site 566546012547 L-rhamnose isomerase; Provisional; Region: PRK01076 566546012548 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 566546012549 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 566546012550 N- and C-terminal domain interface [polypeptide binding]; other site 566546012551 active site 566546012552 putative catalytic site [active] 566546012553 metal binding site [ion binding]; metal-binding site 566546012554 ATP binding site [chemical binding]; other site 566546012555 rhamnulokinase; Provisional; Region: rhaB; PRK10640 566546012556 carbohydrate binding site [chemical binding]; other site 566546012557 transcriptional activator RhaS; Provisional; Region: PRK13503 566546012558 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 566546012559 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546012560 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546012561 transcriptional activator RhaR; Provisional; Region: PRK13500 566546012562 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 566546012563 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546012564 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546012565 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 566546012566 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 566546012567 superoxide dismutase; Provisional; Region: PRK10925 566546012568 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 566546012569 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 566546012570 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 566546012571 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 566546012572 MOSC domain; Region: MOSC; pfam03473 566546012573 3-alpha domain; Region: 3-alpha; pfam03475 566546012574 two-component sensor protein; Provisional; Region: cpxA; PRK09470 566546012575 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 566546012576 dimerization interface [polypeptide binding]; other site 566546012577 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 566546012578 dimer interface [polypeptide binding]; other site 566546012579 phosphorylation site [posttranslational modification] 566546012580 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546012581 ATP binding site [chemical binding]; other site 566546012582 Mg2+ binding site [ion binding]; other site 566546012583 G-X-G motif; other site 566546012584 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 566546012585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546012586 active site 566546012587 intermolecular recognition site; other site 566546012588 dimerization interface [polypeptide binding]; other site 566546012589 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 566546012590 DNA binding site [nucleotide binding] 566546012591 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 566546012592 dimer interface [polypeptide binding]; other site 566546012593 integrase; Provisional; Region: int; PHA02601 566546012594 Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family. They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797 566546012595 active site 566546012596 catalytic residues [active] 566546012597 Int/Topo IB signature motif; other site 566546012598 dimer interface [polypeptide binding]; other site 566546012599 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 566546012600 non-specific DNA binding site [nucleotide binding]; other site 566546012601 salt bridge; other site 566546012602 sequence-specific DNA binding site [nucleotide binding]; other site 566546012603 Regulatory phage protein cox; Region: Phage_Cox; pfam10743 566546012604 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 566546012605 DksA-like zinc finger domain containing protein; Region: PHA00080 566546012606 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 566546012607 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 566546012608 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 566546012609 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 566546012610 cofactor binding site; other site 566546012611 DNA binding site [nucleotide binding] 566546012612 substrate interaction site [chemical binding]; other site 566546012613 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 566546012614 ParB-like nuclease domain; Region: ParB; smart00470 566546012615 portal vertex protein; Provisional; Region: Q; PHA02536 566546012616 Phage portal protein; Region: Phage_portal; pfam04860 566546012617 terminase ATPase subunit; Provisional; Region: P; PHA02535 566546012618 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 566546012620 terminase endonuclease subunit; Provisional; Region: M; PHA02537 566546012621 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 566546012622 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 566546012623 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 566546012624 Phage holin family 2; Region: Phage_holin_2; pfam04550 566546012625 pseudogene, hypothetical protein 566546012626 pseudogene, truncated lysozyme 566546012627 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 566546012628 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 566546012629 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 566546012630 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 566546012631 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 566546012632 baseplate wedge subunit; Provisional; Region: W; PHA02516 566546012633 baseplate assembly protein; Provisional; Region: J; PHA02568 566546012634 phage tail protein, P2 protein I family; Region: tail_P2_I; TIGR01634 566546012635 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 566546012636 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 566546012637 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 566546012638 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 566546012639 major tail sheath protein; Provisional; Region: FI; PHA02560 566546012640 major tail tube protein; Provisional; Region: FII; PHA02600 566546012641 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 566546012642 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 566546012643 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 566546012644 tail protein; Provisional; Region: D; PHA02561 566546012645 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 566546012646 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 566546012647 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 566546012648 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 566546012649 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 566546012650 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 566546012651 active site 566546012652 ADP/pyrophosphate binding site [chemical binding]; other site 566546012653 dimerization interface [polypeptide binding]; other site 566546012654 allosteric effector site; other site 566546012655 fructose-1,6-bisphosphate binding site; other site 566546012656 sulfate transporter subunit; Provisional; Region: PRK10752 566546012657 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 566546012658 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 566546012659 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 566546012660 triosephosphate isomerase; Provisional; Region: PRK14567 566546012661 substrate binding site [chemical binding]; other site 566546012662 dimer interface [polypeptide binding]; other site 566546012663 catalytic triad [active] 566546012664 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 566546012665 Predicted membrane protein [Function unknown]; Region: COG3152 566546012666 hypothetical protein; Provisional; Region: PRK09981 566546012667 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 566546012668 Ligand Binding Site [chemical binding]; other site 566546012669 ferredoxin-NADP reductase; Provisional; Region: PRK10926 566546012670 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 566546012671 FAD binding pocket [chemical binding]; other site 566546012672 FAD binding motif [chemical binding]; other site 566546012673 phosphate binding motif [ion binding]; other site 566546012674 beta-alpha-beta structure motif; other site 566546012675 NAD binding pocket [chemical binding]; other site 566546012676 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 566546012677 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 566546012678 putative active site [active] 566546012679 glycerol kinase; Provisional; Region: glpK; PRK00047 566546012680 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 566546012681 N- and C-terminal domain interface [polypeptide binding]; other site 566546012682 active site 566546012683 MgATP binding site [chemical binding]; other site 566546012684 catalytic site [active] 566546012685 metal binding site [ion binding]; metal-binding site 566546012686 glycerol binding site [chemical binding]; other site 566546012687 homotetramer interface [polypeptide binding]; other site 566546012688 homodimer interface [polypeptide binding]; other site 566546012689 FBP binding site [chemical binding]; other site 566546012690 protein IIAGlc interface [polypeptide binding]; other site 566546012691 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 566546012692 amphipathic channel; other site 566546012693 Asn-Pro-Ala signature motifs; other site 566546012694 septal ring assembly protein ZapB; Provisional; Region: PRK15422 566546012695 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 566546012696 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 566546012697 UbiA prenyltransferase family; Region: UbiA; pfam01040 566546012698 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 566546012699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546012700 Walker A motif; other site 566546012701 ATP binding site [chemical binding]; other site 566546012702 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 566546012703 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 566546012704 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 566546012705 active site 566546012706 HslU subunit interaction site [polypeptide binding]; other site 566546012707 essential cell division protein FtsN; Provisional; Region: PRK10927 566546012708 cell division protein FtsN; Provisional; Region: PRK12757 566546012709 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 566546012710 DNA binding site [nucleotide binding] 566546012711 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 566546012712 domain linker motif; other site 566546012713 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 566546012714 dimerization interface [polypeptide binding]; other site 566546012715 ligand binding site [chemical binding]; other site 566546012716 primosome assembly protein PriA; Validated; Region: PRK05580 566546012717 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 566546012718 ATP binding site [chemical binding]; other site 566546012719 putative Mg++ binding site [ion binding]; other site 566546012720 helicase superfamily c-terminal domain; Region: HELICc; smart00490 566546012721 ATP-binding site [chemical binding]; other site 566546012722 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 566546012723 PAAR motif; Region: PAAR_motif; cl15808 566546012724 RHS Repeat; Region: RHS_repeat; cl11982 566546012725 RHS Repeat; Region: RHS_repeat; pfam05593 566546012726 RHS Repeat; Region: RHS_repeat; cl11982 566546012727 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 566546012728 RHS Repeat; Region: RHS_repeat; pfam05593 566546012729 RHS Repeat; Region: RHS_repeat; pfam05593 566546012730 RHS protein; Region: RHS; pfam03527 566546012731 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 566546012732 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 566546012733 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 566546012734 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 566546012735 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 566546012736 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 566546012737 hypothetical protein; Provisional; Region: PRK10030 566546012738 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 566546012739 Transposase; Region: DEDD_Tnp_IS110; pfam01548 566546012740 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 566546012741 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 566546012742 dimerization interface [polypeptide binding]; other site 566546012743 DNA binding site [nucleotide binding] 566546012744 corepressor binding sites; other site 566546012745 cystathionine gamma-synthase; Provisional; Region: PRK08045 566546012746 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 566546012747 homodimer interface [polypeptide binding]; other site 566546012748 substrate-cofactor binding pocket; other site 566546012749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546012750 catalytic residue [active] 566546012751 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 566546012752 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 566546012753 putative catalytic residues [active] 566546012754 putative nucleotide binding site [chemical binding]; other site 566546012755 putative aspartate binding site [chemical binding]; other site 566546012756 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 566546012757 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 566546012758 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 566546012759 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 566546012760 FAD binding site [chemical binding]; other site 566546012761 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 566546012762 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 566546012763 heme binding site [chemical binding]; other site 566546012764 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 566546012765 EamA-like transporter family; Region: EamA; pfam00892 566546012766 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 566546012767 EamA-like transporter family; Region: EamA; pfam00892 566546012768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 566546012769 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 566546012770 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 566546012771 dimer interface [polypeptide binding]; other site 566546012772 active site 566546012773 metal binding site [ion binding]; metal-binding site 566546012774 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 566546012775 active site 566546012776 intersubunit interactions; other site 566546012777 catalytic residue [active] 566546012778 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 566546012779 dimerization domain swap beta strand [polypeptide binding]; other site 566546012780 regulatory protein interface [polypeptide binding]; other site 566546012781 active site 566546012782 regulatory phosphorylation site [posttranslational modification]; other site 566546012783 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 566546012784 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 566546012785 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 566546012786 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 566546012787 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 566546012788 active site 566546012789 phosphorylation site [posttranslational modification] 566546012790 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 566546012791 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 566546012792 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 566546012793 active site 566546012794 P-loop; other site 566546012795 phosphorylation site [posttranslational modification] 566546012796 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 566546012797 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 566546012798 dimer interface [polypeptide binding]; other site 566546012799 active site 566546012800 glycine loop; other site 566546012801 pyruvate formate lyase II activase; Provisional; Region: PRK10076 566546012802 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 566546012803 active site 566546012804 P-loop; other site 566546012805 phosphorylation site [posttranslational modification] 566546012806 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 566546012807 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546012808 hypothetical protein; Provisional; Region: PRK10649 566546012809 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 566546012810 Sulfatase; Region: Sulfatase; pfam00884 566546012811 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 566546012812 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 566546012813 acetylornithine deacetylase; Provisional; Region: PRK05111 566546012814 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 566546012815 metal binding site [ion binding]; metal-binding site 566546012816 putative dimer interface [polypeptide binding]; other site 566546012817 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 566546012818 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 566546012819 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 566546012820 nucleotide binding site [chemical binding]; other site 566546012821 N-acetyl-L-glutamate binding site [chemical binding]; other site 566546012822 argininosuccinate lyase; Provisional; Region: PRK04833 566546012823 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 566546012824 active sites [active] 566546012825 tetramer interface [polypeptide binding]; other site 566546012826 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 566546012827 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546012828 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 566546012829 dimerization interface [polypeptide binding]; other site 566546012830 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 566546012831 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 566546012832 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 566546012833 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 566546012834 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 566546012835 hypothetical protein; Provisional; Region: PRK11056 566546012836 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 566546012837 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546012838 S-adenosylmethionine binding site [chemical binding]; other site 566546012839 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 566546012840 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 566546012841 N-terminal plug; other site 566546012842 ligand-binding site [chemical binding]; other site 566546012843 glutamate racemase; Provisional; Region: PRK00865 566546012844 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 566546012845 FAD binding domain; Region: FAD_binding_4; pfam01565 566546012846 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 566546012847 Biotin operon repressor [Transcription]; Region: BirA; COG1654 566546012848 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 566546012849 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 566546012850 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 566546012851 pantothenate kinase; Provisional; Region: PRK05439 566546012852 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 566546012853 ATP-binding site [chemical binding]; other site 566546012854 CoA-binding site [chemical binding]; other site 566546012855 Mg2+-binding site [ion binding]; other site 566546012856 pseudogene, Truncated protein chain elongation factor EF-Tu 566546012857 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 566546012858 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 566546012859 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 566546012860 putative homodimer interface [polypeptide binding]; other site 566546012861 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 566546012862 heterodimer interface [polypeptide binding]; other site 566546012863 homodimer interface [polypeptide binding]; other site 566546012864 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 566546012865 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 566546012866 23S rRNA interface [nucleotide binding]; other site 566546012867 L7/L12 interface [polypeptide binding]; other site 566546012868 putative thiostrepton binding site; other site 566546012869 L25 interface [polypeptide binding]; other site 566546012870 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 566546012871 mRNA/rRNA interface [nucleotide binding]; other site 566546012872 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 566546012873 23S rRNA interface [nucleotide binding]; other site 566546012874 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 566546012875 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 566546012876 core dimer interface [polypeptide binding]; other site 566546012877 peripheral dimer interface [polypeptide binding]; other site 566546012878 L10 interface [polypeptide binding]; other site 566546012879 L11 interface [polypeptide binding]; other site 566546012880 putative EF-Tu interaction site [polypeptide binding]; other site 566546012881 putative EF-G interaction site [polypeptide binding]; other site 566546012882 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 566546012883 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 566546012884 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 566546012885 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 566546012886 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 566546012887 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 566546012888 RPB3 interaction site [polypeptide binding]; other site 566546012889 RPB1 interaction site [polypeptide binding]; other site 566546012890 RPB11 interaction site [polypeptide binding]; other site 566546012891 RPB10 interaction site [polypeptide binding]; other site 566546012892 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 566546012893 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 566546012894 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 566546012895 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 566546012896 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 566546012897 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 566546012898 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 566546012899 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 566546012900 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 566546012901 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 566546012902 DNA binding site [nucleotide binding] 566546012903 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 566546012904 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 566546012905 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 566546012906 FeS/SAM binding site; other site 566546012907 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 566546012908 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 566546012909 ThiS interaction site; other site 566546012910 putative active site [active] 566546012911 tetramer interface [polypeptide binding]; other site 566546012912 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 566546012913 thiS-thiF/thiG interaction site; other site 566546012914 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 566546012915 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 566546012916 ATP binding site [chemical binding]; other site 566546012917 substrate interface [chemical binding]; other site 566546012918 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 566546012919 thiamine phosphate binding site [chemical binding]; other site 566546012920 active site 566546012921 pyrophosphate binding site [ion binding]; other site 566546012922 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 566546012923 ThiC-associated domain; Region: ThiC-associated; pfam13667 566546012924 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 566546012925 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 566546012926 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 566546012927 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 566546012928 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 566546012929 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 566546012930 putative NADH binding site [chemical binding]; other site 566546012931 putative active site [active] 566546012932 nudix motif; other site 566546012933 putative metal binding site [ion binding]; other site 566546012934 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 566546012935 substrate binding site [chemical binding]; other site 566546012936 active site 566546012937 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 566546012938 Active_site [active] 566546012939 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 566546012940 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 566546012941 IHF dimer interface [polypeptide binding]; other site 566546012942 IHF - DNA interface [nucleotide binding]; other site 566546012943 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 566546012944 zinc resistance protein; Provisional; Region: zraP; PRK11546 566546012945 dimer interface [polypeptide binding]; other site 566546012946 sensor protein ZraS; Provisional; Region: PRK10364 566546012947 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 566546012948 dimer interface [polypeptide binding]; other site 566546012949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546012950 ATP binding site [chemical binding]; other site 566546012951 Mg2+ binding site [ion binding]; other site 566546012952 G-X-G motif; other site 566546012953 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 566546012954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546012955 active site 566546012956 phosphorylation site [posttranslational modification] 566546012957 intermolecular recognition site; other site 566546012958 dimerization interface [polypeptide binding]; other site 566546012959 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546012960 Walker A motif; other site 566546012961 ATP binding site [chemical binding]; other site 566546012962 Walker B motif; other site 566546012963 arginine finger; other site 566546012964 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 566546012965 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 566546012966 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 566546012967 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 566546012968 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 566546012969 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 566546012970 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 566546012971 purine monophosphate binding site [chemical binding]; other site 566546012972 dimer interface [polypeptide binding]; other site 566546012973 putative catalytic residues [active] 566546012974 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 566546012975 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 566546012976 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 566546012977 Coenzyme A binding pocket [chemical binding]; other site 566546012978 homoserine O-succinyltransferase; Provisional; Region: PRK05368 566546012979 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 566546012980 proposed active site lysine [active] 566546012981 conserved cys residue [active] 566546012982 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 566546012983 malate synthase A; Region: malate_syn_A; TIGR01344 566546012984 active site 566546012985 isocitrate lyase; Provisional; Region: PRK15063 566546012986 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 566546012987 tetramer interface [polypeptide binding]; other site 566546012988 active site 566546012989 Mg2+/Mn2+ binding site [ion binding]; other site 566546012990 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 566546012991 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 566546012992 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 566546012993 transcriptional repressor IclR; Provisional; Region: PRK11569 566546012994 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 566546012995 Bacterial transcriptional regulator; Region: IclR; pfam01614 566546012996 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 566546012997 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 566546012998 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 566546012999 substrate binding pocket [chemical binding]; other site 566546013000 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 566546013001 B12 binding site [chemical binding]; other site 566546013002 cobalt ligand [ion binding]; other site 566546013003 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 566546013004 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 566546013005 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 566546013006 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 566546013007 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 566546013008 active site pocket [active] 566546013009 oxyanion hole [active] 566546013010 catalytic triad [active] 566546013011 active site nucleophile [active] 566546013012 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 566546013013 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 566546013014 RNA binding surface [nucleotide binding]; other site 566546013015 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 566546013016 probable active site [active] 566546013017 hypothetical protein; Provisional; Region: PRK10515 566546013018 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 566546013019 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 566546013020 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 566546013021 Zeta toxin; Region: Zeta_toxin; pfam06414 566546013022 aspartate kinase III; Validated; Region: PRK09084 566546013023 AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258 566546013024 nucleotide binding site [chemical binding]; other site 566546013025 putative catalytic residues [active] 566546013026 aspartate binding site [chemical binding]; other site 566546013027 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 566546013028 lysine allosteric regulatory site; other site 566546013029 dimer interface [polypeptide binding]; other site 566546013030 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 566546013031 dimer interface [polypeptide binding]; other site 566546013032 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 566546013033 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 566546013034 active site 566546013035 dimer interface [polypeptide binding]; other site 566546013036 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 566546013037 dimer interface [polypeptide binding]; other site 566546013038 active site 566546013039 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 566546013040 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 566546013041 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 566546013042 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 566546013043 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 566546013044 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546013045 putative substrate translocation pore; other site 566546013046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546013047 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 566546013048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546013049 dimer interface [polypeptide binding]; other site 566546013050 conserved gate region; other site 566546013051 putative PBP binding loops; other site 566546013052 ABC-ATPase subunit interface; other site 566546013053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546013054 dimer interface [polypeptide binding]; other site 566546013055 conserved gate region; other site 566546013056 putative PBP binding loops; other site 566546013057 ABC-ATPase subunit interface; other site 566546013058 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 566546013059 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 566546013060 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 566546013061 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 566546013062 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 566546013063 Walker A/P-loop; other site 566546013064 ATP binding site [chemical binding]; other site 566546013065 Q-loop/lid; other site 566546013066 ABC transporter signature motif; other site 566546013067 Walker B; other site 566546013068 D-loop; other site 566546013069 H-loop/switch region; other site 566546013070 TOBE domain; Region: TOBE_2; pfam08402 566546013071 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 566546013072 trimer interface; other site 566546013073 sugar binding site [chemical binding]; other site 566546013074 maltose regulon periplasmic protein; Provisional; Region: PRK10564 566546013075 hypothetical protein; Validated; Region: PRK09718 566546013076 pseudogene, hypothetical protein 566546013077 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 566546013078 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 566546013079 UbiA prenyltransferase family; Region: UbiA; pfam01040 566546013080 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 566546013081 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 566546013082 putative acyl-acceptor binding pocket; other site 566546013083 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 566546013084 LexA repressor; Validated; Region: PRK00215 566546013085 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 566546013086 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 566546013087 Catalytic site [active] 566546013088 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 566546013089 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 566546013090 hypothetical protein; Provisional; Region: PRK10428 566546013091 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 566546013092 metal binding site 2 [ion binding]; metal-binding site 566546013093 putative DNA binding helix; other site 566546013094 metal binding site 1 [ion binding]; metal-binding site 566546013095 dimer interface [polypeptide binding]; other site 566546013096 structural Zn2+ binding site [ion binding]; other site 566546013097 pseudogene, hypothetical protein 566546013098 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 566546013099 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 566546013100 FMN binding site [chemical binding]; other site 566546013101 active site 566546013102 catalytic residues [active] 566546013103 substrate binding site [chemical binding]; other site 566546013104 phage shock protein G; Reviewed; Region: pspG; PRK09459 566546013105 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 566546013106 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 566546013107 NADP binding site [chemical binding]; other site 566546013108 dimer interface [polypeptide binding]; other site 566546013109 replicative DNA helicase; Provisional; Region: PRK08006 566546013110 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 566546013111 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 566546013112 Walker A motif; other site 566546013113 ATP binding site [chemical binding]; other site 566546013114 Walker B motif; other site 566546013115 DNA binding loops [nucleotide binding] 566546013116 alanine racemase; Reviewed; Region: alr; PRK00053 566546013117 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 566546013118 active site 566546013119 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 566546013120 substrate binding site [chemical binding]; other site 566546013121 catalytic residues [active] 566546013122 dimer interface [polypeptide binding]; other site 566546013123 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 566546013124 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 566546013125 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546013126 homodimer interface [polypeptide binding]; other site 566546013127 catalytic residue [active] 566546013128 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 566546013129 active site 566546013130 motif I; other site 566546013131 motif II; other site 566546013132 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 566546013133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 566546013134 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 566546013135 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 566546013136 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 566546013137 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 566546013138 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 566546013139 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 566546013140 dimer interface [polypeptide binding]; other site 566546013141 ssDNA binding site [nucleotide binding]; other site 566546013142 tetramer (dimer of dimers) interface [polypeptide binding]; other site 566546013143 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 566546013144 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 566546013145 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 566546013146 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 566546013147 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 566546013148 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546013149 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 566546013150 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 566546013151 DNA binding residues [nucleotide binding] 566546013152 dimer interface [polypeptide binding]; other site 566546013153 [2Fe-2S] cluster binding site [ion binding]; other site 566546013154 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 566546013155 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 566546013156 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 566546013157 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 566546013158 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 566546013159 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 566546013160 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 566546013161 Na binding site [ion binding]; other site 566546013162 Predicted membrane protein [Function unknown]; Region: COG3162 566546013163 acetyl-CoA synthetase; Provisional; Region: PRK00174 566546013164 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 566546013165 active site 566546013166 CoA binding site [chemical binding]; other site 566546013167 acyl-activating enzyme (AAE) consensus motif; other site 566546013168 AMP binding site [chemical binding]; other site 566546013169 acetate binding site [chemical binding]; other site 566546013170 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 566546013171 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 566546013172 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 566546013173 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 566546013174 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 566546013175 heme lyase subunit NrfE; Provisional; Region: PRK10369 566546013176 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 566546013177 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 566546013178 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 566546013179 binding surface 566546013180 TPR motif; other site 566546013181 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 566546013182 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 566546013183 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 566546013184 Sel1-like repeats; Region: SEL1; smart00671 566546013185 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 566546013186 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 566546013187 [4Fe-4S] binding site [ion binding]; other site 566546013188 molybdopterin cofactor binding site; other site 566546013189 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 566546013190 molybdopterin cofactor binding site; other site 566546013191 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 566546013192 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 566546013193 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 566546013194 multidrug resistance protein MdtN; Provisional; Region: PRK10476 566546013195 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 566546013196 HlyD family secretion protein; Region: HlyD_3; pfam13437 566546013197 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 566546013198 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 566546013199 pseudogene, ribose 5-phosphate isomerase B/allose 6-phosphate isomerase 566546013200 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 566546013201 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 566546013202 Coenzyme A binding pocket [chemical binding]; other site 566546013203 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 566546013204 AAA domain; Region: AAA_18; pfam13238 566546013205 active site 566546013206 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 566546013207 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 566546013208 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 566546013209 active site 566546013210 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 566546013211 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 566546013212 Walker A/P-loop; other site 566546013213 ATP binding site [chemical binding]; other site 566546013214 Q-loop/lid; other site 566546013215 ABC transporter signature motif; other site 566546013216 Walker B; other site 566546013217 D-loop; other site 566546013218 H-loop/switch region; other site 566546013219 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 566546013220 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 566546013221 Walker A/P-loop; other site 566546013222 ATP binding site [chemical binding]; other site 566546013223 Q-loop/lid; other site 566546013224 ABC transporter signature motif; other site 566546013225 Walker B; other site 566546013226 D-loop; other site 566546013227 H-loop/switch region; other site 566546013228 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 566546013229 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 566546013230 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 566546013231 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 566546013232 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 566546013233 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 566546013234 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 566546013235 DNA-binding site [nucleotide binding]; DNA binding site 566546013236 UTRA domain; Region: UTRA; pfam07702 566546013237 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 566546013238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 566546013239 dimer interface [polypeptide binding]; other site 566546013240 conserved gate region; other site 566546013241 putative PBP binding loops; other site 566546013242 ABC-ATPase subunit interface; other site 566546013243 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 566546013244 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 566546013245 substrate binding pocket [chemical binding]; other site 566546013246 membrane-bound complex binding site; other site 566546013247 hinge residues; other site 566546013248 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 566546013249 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 566546013250 Walker A/P-loop; other site 566546013251 ATP binding site [chemical binding]; other site 566546013252 Q-loop/lid; other site 566546013253 ABC transporter signature motif; other site 566546013254 Walker B; other site 566546013255 D-loop; other site 566546013256 H-loop/switch region; other site 566546013257 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 566546013258 dimer interface [polypeptide binding]; other site 566546013259 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 566546013260 hypothetical protein; Provisional; Region: PRK10220 566546013261 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 566546013262 PhnA protein; Region: PhnA; pfam03831 566546013263 hypothetical protein; Provisional; Region: PRK09866 566546013264 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 566546013265 G1 box; other site 566546013266 GTP/Mg2+ binding site [chemical binding]; other site 566546013267 G2 box; other site 566546013268 Switch I region; other site 566546013269 G3 box; other site 566546013270 Switch II region; other site 566546013271 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 566546013272 G2 box; other site 566546013273 Switch I region; other site 566546013274 G3 box; other site 566546013275 Switch II region; other site 566546013276 G4 box; other site 566546013277 G5 box; other site 566546013278 YjcZ-like protein; Region: YjcZ; pfam13990 566546013279 proline/glycine betaine transporter; Provisional; Region: PRK10642 566546013280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546013281 putative substrate translocation pore; other site 566546013282 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 566546013283 sensor protein BasS/PmrB; Provisional; Region: PRK10755 566546013284 HAMP domain; Region: HAMP; pfam00672 566546013285 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 566546013286 dimer interface [polypeptide binding]; other site 566546013287 phosphorylation site [posttranslational modification] 566546013288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546013289 ATP binding site [chemical binding]; other site 566546013290 Mg2+ binding site [ion binding]; other site 566546013291 G-X-G motif; other site 566546013292 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 566546013293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546013294 active site 566546013295 phosphorylation site [posttranslational modification] 566546013296 intermolecular recognition site; other site 566546013297 dimerization interface [polypeptide binding]; other site 566546013298 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 566546013299 DNA binding site [nucleotide binding] 566546013300 putative metal dependent hydrolase; Provisional; Region: PRK11598 566546013301 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 566546013302 Sulfatase; Region: Sulfatase; pfam00884 566546013303 arginine:agmatin antiporter; Provisional; Region: PRK10644 566546013304 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 566546013305 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546013306 arginine decarboxylase; Provisional; Region: PRK15029 566546013307 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 566546013308 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 566546013309 homodimer interface [polypeptide binding]; other site 566546013310 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546013311 catalytic residue [active] 566546013312 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 566546013313 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 566546013314 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546013315 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546013316 alpha-galactosidase; Provisional; Region: PRK15076 566546013317 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 566546013318 NAD binding site [chemical binding]; other site 566546013319 sugar binding site [chemical binding]; other site 566546013320 divalent metal binding site [ion binding]; other site 566546013321 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 566546013322 dimer interface [polypeptide binding]; other site 566546013323 melibiose:sodium symporter; Provisional; Region: PRK10429 566546013324 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 566546013325 hypothetical protein; Provisional; Region: PRK09867 566546013326 fumarate hydratase; Provisional; Region: PRK15389 566546013327 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 566546013328 Fumarase C-terminus; Region: Fumerase_C; pfam05683 566546013329 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 566546013330 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 566546013331 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 566546013332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546013333 active site 566546013334 phosphorylation site [posttranslational modification] 566546013335 intermolecular recognition site; other site 566546013336 dimerization interface [polypeptide binding]; other site 566546013337 Transcriptional regulator; Region: CitT; pfam12431 566546013338 sensory histidine kinase DcuS; Provisional; Region: PRK11086 566546013339 PAS domain; Region: PAS; smart00091 566546013340 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546013341 ATP binding site [chemical binding]; other site 566546013342 Mg2+ binding site [ion binding]; other site 566546013343 G-X-G motif; other site 566546013344 Uncharacterized conserved protein [Function unknown]; Region: COG3592 566546013345 Predicted acetyltransferase [General function prediction only]; Region: COG2388 566546013346 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 566546013347 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 566546013348 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 566546013349 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 566546013350 dimer interface [polypeptide binding]; other site 566546013351 putative anticodon binding site; other site 566546013352 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 566546013353 motif 1; other site 566546013354 active site 566546013355 motif 2; other site 566546013356 motif 3; other site 566546013357 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 566546013358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546013359 putative substrate translocation pore; other site 566546013360 POT family; Region: PTR2; pfam00854 566546013361 lysine decarboxylase CadA; Provisional; Region: PRK15400 566546013362 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 566546013363 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 566546013364 homodimer interface [polypeptide binding]; other site 566546013365 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546013366 catalytic residue [active] 566546013367 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 566546013368 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 566546013369 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 566546013370 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 566546013371 DNA binding site [nucleotide binding] 566546013372 putative transcriptional regulator; Provisional; Region: PRK11640 566546013373 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 566546013374 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 566546013375 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 566546013376 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 566546013377 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 566546013378 DsbD alpha interface [polypeptide binding]; other site 566546013379 catalytic residues [active] 566546013380 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 566546013381 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 566546013382 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 566546013383 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 566546013384 Aspartase; Region: Aspartase; cd01357 566546013385 active sites [active] 566546013386 tetramer interface [polypeptide binding]; other site 566546013387 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 566546013388 putative transporter; Provisional; Region: PRK11021 566546013389 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 566546013390 oligomerisation interface [polypeptide binding]; other site 566546013391 mobile loop; other site 566546013392 roof hairpin; other site 566546013393 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 566546013394 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 566546013395 ring oligomerisation interface [polypeptide binding]; other site 566546013396 ATP/Mg binding site [chemical binding]; other site 566546013397 stacking interactions; other site 566546013398 hinge regions; other site 566546013399 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 566546013400 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 566546013401 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 566546013402 FeS/SAM binding site; other site 566546013403 elongation factor P; Validated; Region: PRK00529 566546013404 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 566546013405 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 566546013406 RNA binding site [nucleotide binding]; other site 566546013407 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 566546013408 RNA binding site [nucleotide binding]; other site 566546013409 entericidin A; Provisional; Region: PRK09810 566546013410 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 566546013411 putative mini-ykkC riboswitch; ECW_nc4511 566546013412 multidrug efflux system protein; Provisional; Region: PRK11431 566546013413 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 566546013414 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 566546013415 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 566546013416 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 566546013417 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 566546013418 Iron-sulfur protein interface; other site 566546013419 proximal quinone binding site [chemical binding]; other site 566546013420 C-subunit interface; other site 566546013421 distal quinone binding site; other site 566546013422 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 566546013423 D-subunit interface [polypeptide binding]; other site 566546013424 Iron-sulfur protein interface; other site 566546013425 proximal quinone binding site [chemical binding]; other site 566546013426 distal quinone binding site [chemical binding]; other site 566546013427 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 566546013428 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 566546013429 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 566546013430 L-aspartate oxidase; Provisional; Region: PRK06175 566546013431 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 566546013432 poxB regulator PoxA; Provisional; Region: PRK09350 566546013433 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 566546013434 motif 1; other site 566546013435 dimer interface [polypeptide binding]; other site 566546013436 active site 566546013437 motif 2; other site 566546013438 motif 3; other site 566546013439 inner membrane transporter YjeM; Provisional; Region: PRK15238 566546013440 putative mechanosensitive channel protein; Provisional; Region: PRK10929 566546013441 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 566546013442 DNA-binding site [nucleotide binding]; DNA binding site 566546013443 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 566546013444 Mechanosensitive ion channel; Region: MS_channel; pfam00924 566546013445 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 566546013446 GTPase RsgA; Reviewed; Region: PRK12288 566546013447 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 566546013448 RNA binding site [nucleotide binding]; other site 566546013449 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 566546013450 GTPase/Zn-binding domain interface [polypeptide binding]; other site 566546013451 GTP/Mg2+ binding site [chemical binding]; other site 566546013452 G4 box; other site 566546013453 G5 box; other site 566546013454 G1 box; other site 566546013455 Switch I region; other site 566546013456 G2 box; other site 566546013457 G3 box; other site 566546013458 Switch II region; other site 566546013459 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 566546013460 catalytic site [active] 566546013461 putative active site [active] 566546013462 putative substrate binding site [chemical binding]; other site 566546013463 dimer interface [polypeptide binding]; other site 566546013464 epoxyqueuosine reductase; Region: TIGR00276 566546013465 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 566546013466 putative carbohydrate kinase; Provisional; Region: PRK10565 566546013467 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 566546013468 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 566546013469 putative substrate binding site [chemical binding]; other site 566546013470 putative ATP binding site [chemical binding]; other site 566546013471 ADP-binding protein; Provisional; Region: PRK10646 566546013472 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 566546013473 AMIN domain; Region: AMIN; pfam11741 566546013474 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 566546013475 active site 566546013476 metal binding site [ion binding]; metal-binding site 566546013477 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 566546013478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546013479 ATP binding site [chemical binding]; other site 566546013480 Mg2+ binding site [ion binding]; other site 566546013481 G-X-G motif; other site 566546013482 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 566546013483 ATP binding site [chemical binding]; other site 566546013484 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 566546013485 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 566546013486 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 566546013487 bacterial Hfq-like; Region: Hfq; cd01716 566546013488 hexamer interface [polypeptide binding]; other site 566546013489 Sm1 motif; other site 566546013490 RNA binding site [nucleotide binding]; other site 566546013491 Sm2 motif; other site 566546013492 GTPase HflX; Provisional; Region: PRK11058 566546013493 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 566546013494 HflX GTPase family; Region: HflX; cd01878 566546013495 G1 box; other site 566546013496 GTP/Mg2+ binding site [chemical binding]; other site 566546013497 Switch I region; other site 566546013498 G2 box; other site 566546013499 G3 box; other site 566546013500 Switch II region; other site 566546013501 G4 box; other site 566546013502 G5 box; other site 566546013503 FtsH protease regulator HflK; Provisional; Region: PRK10930 566546013504 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 566546013505 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 566546013506 FtsH protease regulator HflC; Provisional; Region: PRK11029 566546013507 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 566546013508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 566546013509 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 566546013510 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 566546013511 GDP-binding site [chemical binding]; other site 566546013512 ACT binding site; other site 566546013513 IMP binding site; other site 566546013514 Predicted transcriptional regulator [Transcription]; Region: COG1959 566546013515 transcriptional repressor NsrR; Provisional; Region: PRK11014 566546013516 exoribonuclease R; Provisional; Region: PRK11642 566546013517 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 566546013518 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 566546013519 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 566546013520 RNB domain; Region: RNB; pfam00773 566546013521 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 566546013522 RNA binding site [nucleotide binding]; other site 566546013523 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 566546013524 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 566546013525 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 566546013526 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 566546013527 PspA/IM30 family; Region: PspA_IM30; pfam04012 566546013528 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 566546013529 Predicted membrane protein [Function unknown]; Region: COG3766 566546013530 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 566546013531 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 566546013532 Predicted integral membrane protein [Function unknown]; Region: COG5463 566546013533 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 566546013534 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 566546013535 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 566546013536 FAD binding site [chemical binding]; other site 566546013537 substrate binding site [chemical binding]; other site 566546013538 catalytic residues [active] 566546013539 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 566546013540 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 566546013541 esterase; Provisional; Region: PRK10566 566546013542 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 566546013543 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 566546013544 transcriptional repressor UlaR; Provisional; Region: PRK13509 566546013545 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 566546013546 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 566546013547 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 566546013548 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 566546013549 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 566546013550 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 566546013551 pseudogene, L-ascorbate-specific enzyme IIB component of PTS 566546013552 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 566546013553 active site 566546013554 phosphorylation site [posttranslational modification] 566546013555 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 566546013556 active site 566546013557 dimer interface [polypeptide binding]; other site 566546013558 magnesium binding site [ion binding]; other site 566546013559 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 566546013560 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 566546013561 AP (apurinic/apyrimidinic) site pocket; other site 566546013562 DNA interaction; other site 566546013563 Metal-binding active site; metal-binding site 566546013564 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 566546013565 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 566546013566 intersubunit interface [polypeptide binding]; other site 566546013567 active site 566546013568 Zn2+ binding site [ion binding]; other site 566546013569 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 566546013570 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 566546013571 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 566546013572 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 566546013573 dimer interface [polypeptide binding]; other site 566546013574 ssDNA binding site [nucleotide binding]; other site 566546013575 tetramer (dimer of dimers) interface [polypeptide binding]; other site 566546013576 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 566546013577 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 566546013578 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 566546013579 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 566546013580 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 566546013581 pseudogene, putative IS609 transposase ORF1 566546013582 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 566546013583 Probable transposase; Region: OrfB_IS605; pfam01385 566546013584 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 566546013585 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 566546013586 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 566546013587 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 566546013588 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 566546013589 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 566546013590 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 566546013591 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 566546013592 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 566546013593 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 566546013594 Hemerythrin-like domain; Region: Hr-like; cd12108 566546013595 Fe binding site [ion binding]; other site 566546013596 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 566546013597 EamA-like transporter family; Region: EamA; pfam00892 566546013598 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 566546013599 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 566546013600 NADP binding site [chemical binding]; other site 566546013601 Predicted transcriptional regulators [Transcription]; Region: COG1733 566546013602 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 566546013603 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 566546013604 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 566546013605 active site 566546013606 metal binding site [ion binding]; metal-binding site 566546013607 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 566546013608 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 566546013609 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 566546013610 active site 566546013611 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 566546013612 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 566546013613 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 566546013614 Domain of unknown function DUF21; Region: DUF21; pfam01595 566546013615 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 566546013616 Transporter associated domain; Region: CorC_HlyC; smart01091 566546013617 methionine sulfoxide reductase A; Provisional; Region: PRK00058 566546013618 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 566546013619 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 566546013620 Surface antigen; Region: Bac_surface_Ag; pfam01103 566546013621 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 566546013622 Family of unknown function (DUF490); Region: DUF490; pfam04357 566546013623 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 566546013624 putative active site pocket [active] 566546013625 dimerization interface [polypeptide binding]; other site 566546013626 putative catalytic residue [active] 566546013627 antitoxin ChpS; Provisional; Region: PRK11347 566546013628 PemK-like protein; Region: PemK; cl00995 566546013629 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 566546013630 dimer interface [polypeptide binding]; other site 566546013631 substrate binding site [chemical binding]; other site 566546013632 metal binding sites [ion binding]; metal-binding site 566546013633 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 566546013634 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 566546013635 putative ligand binding site [chemical binding]; other site 566546013636 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 566546013637 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 566546013638 Walker A/P-loop; other site 566546013639 ATP binding site [chemical binding]; other site 566546013640 Q-loop/lid; other site 566546013641 ABC transporter signature motif; other site 566546013642 Walker B; other site 566546013643 D-loop; other site 566546013644 H-loop/switch region; other site 566546013645 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 566546013646 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 566546013647 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 566546013648 TM-ABC transporter signature motif; other site 566546013649 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 566546013650 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 566546013651 TM-ABC transporter signature motif; other site 566546013652 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 566546013653 AMP binding site [chemical binding]; other site 566546013654 metal binding site [ion binding]; metal-binding site 566546013655 active site 566546013656 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 566546013657 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 566546013658 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 566546013659 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 566546013660 hypothetical protein; Provisional; Region: PRK05255 566546013661 peptidase PmbA; Provisional; Region: PRK11040 566546013662 pseudogene, cytochrome b562 566546013663 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 566546013664 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 566546013665 FeS/SAM binding site; other site 566546013666 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 566546013667 ATP cone domain; Region: ATP-cone; pfam03477 566546013668 Class III ribonucleotide reductase; Region: RNR_III; cd01675 566546013669 effector binding site; other site 566546013670 active site 566546013671 Zn binding site [ion binding]; other site 566546013672 glycine loop; other site 566546013673 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 566546013674 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 566546013675 Ca binding site [ion binding]; other site 566546013676 active site 566546013677 catalytic site [active] 566546013678 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 566546013679 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 566546013680 active site turn [active] 566546013681 phosphorylation site [posttranslational modification] 566546013682 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 566546013683 trehalose repressor; Provisional; Region: treR; PRK09492 566546013684 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 566546013685 DNA binding site [nucleotide binding] 566546013686 domain linker motif; other site 566546013687 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 566546013688 dimerization interface [polypeptide binding]; other site 566546013689 ligand binding site [chemical binding]; other site 566546013690 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 566546013691 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 566546013692 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 566546013693 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 566546013694 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 566546013695 motif II; other site 566546013696 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 566546013697 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 566546013698 homotrimer interaction site [polypeptide binding]; other site 566546013699 putative active site [active] 566546013700 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 566546013701 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 566546013702 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 566546013703 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 566546013704 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 566546013705 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 566546013706 PyrBI operon leader peptide; Region: PyrBI_leader; pfam08052 566546013707 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 566546013708 homotrimer interaction site [polypeptide binding]; other site 566546013709 putative active site [active] 566546013710 oxidoreductase; Provisional; Region: PRK12742 566546013711 classical (c) SDRs; Region: SDR_c; cd05233 566546013712 NAD(P) binding site [chemical binding]; other site 566546013713 active site 566546013714 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 566546013715 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 566546013716 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 566546013717 pseudogene, conserved hypothetical protein 566546013718 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 566546013719 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 566546013720 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 566546013721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 566546013722 RNase E inhibitor protein; Provisional; Region: PRK11191 566546013723 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 566546013724 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 566546013725 Coenzyme A binding pocket [chemical binding]; other site 566546013726 Predicted membrane protein [Function unknown]; Region: COG4269 566546013727 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 566546013728 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 566546013729 HIGH motif; other site 566546013730 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 566546013731 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 566546013732 active site 566546013733 KMSKS motif; other site 566546013734 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 566546013735 tRNA binding surface [nucleotide binding]; other site 566546013736 anticodon binding site; other site 566546013737 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 566546013738 DNA polymerase III subunit chi; Validated; Region: PRK05728 566546013739 multifunctional aminopeptidase A; Provisional; Region: PRK00913 566546013740 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 566546013741 interface (dimer of trimers) [polypeptide binding]; other site 566546013742 Substrate-binding/catalytic site; other site 566546013743 Zn-binding sites [ion binding]; other site 566546013744 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 566546013745 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 566546013746 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 566546013747 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 566546013748 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 566546013749 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 566546013750 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 566546013751 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 566546013752 DNA binding site [nucleotide binding] 566546013753 domain linker motif; other site 566546013754 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 566546013755 putative dimerization interface [polypeptide binding]; other site 566546013756 putative ligand binding site [chemical binding]; other site 566546013757 fructuronate transporter; Provisional; Region: PRK10034; cl15264 566546013758 gluconate transporter; Region: gntP; TIGR00791 566546013759 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 566546013760 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 566546013761 NADP binding site [chemical binding]; other site 566546013762 homodimer interface [polypeptide binding]; other site 566546013763 active site 566546013764 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 566546013765 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 566546013766 putative NAD(P) binding site [chemical binding]; other site 566546013767 catalytic Zn binding site [ion binding]; other site 566546013768 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 566546013769 ATP-binding site [chemical binding]; other site 566546013770 Gluconate-6-phosphate binding site [chemical binding]; other site 566546013771 Shikimate kinase; Region: SKI; pfam01202 566546013772 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 566546013773 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 566546013774 putative NAD(P) binding site [chemical binding]; other site 566546013775 putative substrate binding site [chemical binding]; other site 566546013776 catalytic Zn binding site [ion binding]; other site 566546013777 structural Zn binding site [ion binding]; other site 566546013778 dimer interface [polypeptide binding]; other site 566546013779 pseudogene, prophage P4 integrase 566546013780 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 566546013781 HNH endonuclease; Region: HNH_2; pfam13391 566546013782 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 566546013783 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 566546013784 active site 566546013785 catalytic triad [active] 566546013786 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 566546013787 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 566546013788 HsdM N-terminal domain; Region: HsdM_N; pfam12161 566546013789 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 566546013790 Methyltransferase domain; Region: Methyltransf_26; pfam13659 566546013791 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 566546013792 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 566546013793 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 566546013794 ATP binding site [chemical binding]; other site 566546013795 putative Mg++ binding site [ion binding]; other site 566546013796 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 566546013797 Predicted transcriptional regulator [Transcription]; Region: COG2378 566546013798 WYL domain; Region: WYL; cl14852 566546013799 Predicted GTPase [General function prediction only]; Region: COG3596 566546013800 YfjP GTPase; Region: YfjP; cd11383 566546013801 G1 box; other site 566546013802 GTP/Mg2+ binding site [chemical binding]; other site 566546013803 Switch I region; other site 566546013804 G2 box; other site 566546013805 Switch II region; other site 566546013806 G3 box; other site 566546013807 G4 box; other site 566546013808 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 566546013809 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 566546013810 Domain of unknown function (DUF932); Region: DUF932; pfam06067 566546013811 hypothetical protein; Reviewed; Region: PRK00024 566546013812 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 566546013813 MPN+ (JAMM) motif; other site 566546013814 Zinc-binding site [ion binding]; other site 566546013815 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 566546013816 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 566546013817 Methyltransferase domain; Region: Methyltransf_27; pfam13708 566546013818 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 566546013819 integrase; Provisional; Region: PRK09692 566546013820 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 566546013821 active site 566546013822 Int/Topo IB signature motif; other site 566546013823 Protein kinase domain; Region: Pkinase; pfam00069 566546013824 Catalytic domain of Protein Kinases; Region: PKc; cd00180 566546013825 active site 566546013826 ATP binding site [chemical binding]; other site 566546013827 substrate binding site [chemical binding]; other site 566546013828 activation loop (A-loop); other site 566546013829 HerA helicase [Replication, recombination, and repair]; Region: COG0433 566546013830 Domain of unknown function DUF87; Region: DUF87; pfam01935 566546013831 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 566546013832 Methyltransferase domain; Region: Methyltransf_26; pfam13659 566546013833 McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117 566546013834 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 566546013835 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 566546013836 HNH endonuclease; Region: HNH_2; pfam13391 566546013837 Domain of unknown function (DUF303); Region: DUF303; pfam03629 566546013838 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 566546013839 Kelch motif; Region: Kelch_1; pfam01344 566546013840 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 566546013841 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 566546013842 Int/Topo IB signature motif; other site 566546013843 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 566546013844 Int/Topo IB signature motif; other site 566546013845 Fimbrial protein; Region: Fimbrial; cl01416 566546013846 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 566546013847 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 566546013848 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 566546013849 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 566546013850 outer membrane usher protein; Provisional; Region: PRK15193 566546013851 PapC N-terminal domain; Region: PapC_N; pfam13954 566546013852 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 566546013853 PapC C-terminal domain; Region: PapC_C; pfam13953 566546013854 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 566546013855 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 566546013856 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 566546013857 mannosyl binding site [chemical binding]; other site 566546013858 Fimbrial protein; Region: Fimbrial; pfam00419 566546013859 fructuronate transporter; Provisional; Region: PRK10034 566546013860 gluconate transporter; Region: gntP; TIGR00791 566546013861 mannonate dehydratase; Region: uxuA; TIGR00695 566546013862 mannonate dehydratase; Provisional; Region: PRK03906 566546013863 D-mannonate oxidoreductase; Provisional; Region: PRK15037 566546013864 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 566546013865 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 566546013866 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 566546013867 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 566546013868 DNA-binding site [nucleotide binding]; DNA binding site 566546013869 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 566546013870 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 566546013871 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 566546013872 cell density-dependent motility repressor; Provisional; Region: PRK10082 566546013873 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 566546013874 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 566546013875 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 566546013876 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 566546013877 dimer interface [polypeptide binding]; other site 566546013878 active site 566546013879 hypothetical protein; Provisional; Region: PRK10519 566546013880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 566546013881 Nucleoside recognition; Region: Gate; pfam07670 566546013882 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 566546013883 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 566546013884 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 566546013885 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 566546013886 SdiA-regulated; Region: SdiA-regulated; cd09971 566546013887 putative active site [active] 566546013888 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 566546013889 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 566546013890 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 566546013891 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 566546013892 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 566546013893 Predicted membrane protein [Function unknown]; Region: COG2733 566546013894 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 566546013895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546013896 putative substrate translocation pore; other site 566546013897 pseudogene, putative transposase YhgA family protein 566546013898 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 566546013899 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 566546013900 DNA-binding site [nucleotide binding]; DNA binding site 566546013901 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 566546013902 pyridoxal 5'-phosphate binding site [chemical binding]; other site 566546013903 homodimer interface [polypeptide binding]; other site 566546013904 catalytic residue [active] 566546013905 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 566546013906 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 566546013907 Penicillin amidase; Region: Penicil_amidase; pfam01804 566546013908 Penicillin G acylase (PGA) is the key enzyme in the industrial production of beta-lactam antibiotics. PGA hydrolyzes the side chain of penicillin G and related beta-lactam antibiotics releasing 6-amino penicillanic acid (6-APA), a building block in the...; Region: Ntn_PGA; cd03748 566546013909 active site 566546013910 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 566546013911 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 566546013912 P-loop, Walker A motif; other site 566546013913 Base recognition motif; other site 566546013914 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 566546013915 Uncharacterized small protein [Function unknown]; Region: COG2879 566546013916 carbon starvation protein A; Provisional; Region: PRK15015 566546013917 Carbon starvation protein CstA; Region: CstA; pfam02554 566546013918 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 566546013919 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 566546013920 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 566546013921 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 566546013922 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 566546013923 Cupin domain; Region: Cupin_2; pfam07883 566546013924 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546013925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546013926 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 566546013927 putative substrate translocation pore; other site 566546013928 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 566546013929 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 566546013930 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 566546013931 putative substrate binding pocket [chemical binding]; other site 566546013932 trimer interface [polypeptide binding]; other site 566546013933 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 566546013934 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 566546013935 putative active site [active] 566546013936 putative metal binding site [ion binding]; other site 566546013937 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 566546013938 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 566546013939 NAD binding site [chemical binding]; other site 566546013940 catalytic residues [active] 566546013941 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 566546013942 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, N-terminal subunit; Region: HpaG-N-term; TIGR02305 566546013943 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 566546013944 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 566546013945 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 566546013946 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 566546013947 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 566546013948 dimer interface [polypeptide binding]; other site 566546013949 ligand binding site [chemical binding]; other site 566546013950 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 566546013951 dimerization interface [polypeptide binding]; other site 566546013952 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 566546013953 dimer interface [polypeptide binding]; other site 566546013954 putative CheW interface [polypeptide binding]; other site 566546013955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 566546013956 D-galactonate transporter; Region: 2A0114; TIGR00893 566546013957 putative substrate translocation pore; other site 566546013958 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 566546013959 DNA-binding site [nucleotide binding]; DNA binding site 566546013960 Transcriptional regulators [Transcription]; Region: GntR; COG1802 566546013961 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 566546013962 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 566546013963 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 566546013964 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 566546013965 putative NAD(P) binding site [chemical binding]; other site 566546013966 catalytic Zn binding site [ion binding]; other site 566546013967 structural Zn binding site [ion binding]; other site 566546013968 phosphoglycerol transferase I; Provisional; Region: PRK03776 566546013969 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 566546013970 hypothetical protein; Provisional; Region: PRK11667 566546013971 DNA replication protein DnaC; Validated; Region: PRK07952 566546013972 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 566546013973 Walker A motif; other site 566546013974 ATP binding site [chemical binding]; other site 566546013975 Walker B motif; other site 566546013976 primosomal protein DnaI; Provisional; Region: PRK02854 566546013977 hypothetical protein; Provisional; Region: PRK09917 566546013978 Uncharacterized conserved protein [Function unknown]; Region: COG2966 566546013979 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 566546013980 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 566546013981 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 566546013982 DNA binding residues [nucleotide binding] 566546013983 dimerization interface [polypeptide binding]; other site 566546013984 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 566546013985 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 566546013986 DNA binding residues [nucleotide binding] 566546013987 dimerization interface [polypeptide binding]; other site 566546013988 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 566546013989 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 566546013990 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 566546013991 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 566546013992 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 566546013993 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 566546013994 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 566546013995 S-adenosylmethionine binding site [chemical binding]; other site 566546013996 DNA polymerase III, psi subunit [DNA replication, recombination, and repair]; Region: HolD; COG3050 566546013997 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 566546013998 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 566546013999 Coenzyme A binding pocket [chemical binding]; other site 566546014000 dUMP phosphatase; Provisional; Region: PRK09449 566546014001 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 566546014002 motif II; other site 566546014003 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 566546014004 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 566546014005 G1 box; other site 566546014006 putative GEF interaction site [polypeptide binding]; other site 566546014007 GTP/Mg2+ binding site [chemical binding]; other site 566546014008 Switch I region; other site 566546014009 G2 box; other site 566546014010 G3 box; other site 566546014011 Switch II region; other site 566546014012 G4 box; other site 566546014013 G5 box; other site 566546014014 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 566546014015 periplasmic protein; Provisional; Region: PRK10568 566546014016 BON domain; Region: BON; pfam04972 566546014017 BON domain; Region: BON; pfam04972 566546014018 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 566546014019 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 566546014020 active site 566546014021 nucleophile elbow; other site 566546014022 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 566546014023 active site 566546014024 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 566546014025 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 566546014026 FeS/SAM binding site; other site 566546014027 hypothetical protein; Provisional; Region: PRK10977 566546014028 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 566546014029 intersubunit interface [polypeptide binding]; other site 566546014030 active site 566546014031 catalytic residue [active] 566546014032 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 566546014033 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 566546014034 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 566546014035 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 566546014036 phosphopentomutase; Provisional; Region: PRK05362 566546014037 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 566546014038 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 566546014039 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 566546014040 pseudogene, helix-turn-helix domain-containing protein 566546014041 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 566546014042 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 566546014043 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 566546014044 hypothetical protein; Provisional; Region: PRK11246 566546014045 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 566546014046 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 566546014047 motif II; other site 566546014048 DNA repair protein RadA; Region: sms; TIGR00416 566546014049 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 566546014050 Walker A motif/ATP binding site; other site 566546014051 ATP binding site [chemical binding]; other site 566546014052 Walker B motif; other site 566546014053 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 566546014054 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 566546014055 non-specific DNA binding site [nucleotide binding]; other site 566546014056 salt bridge; other site 566546014057 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 566546014058 sequence-specific DNA binding site [nucleotide binding]; other site 566546014059 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 566546014060 active site 566546014061 (T/H)XGH motif; other site 566546014062 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 566546014063 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 566546014064 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 566546014065 Walker A/P-loop; other site 566546014066 ATP binding site [chemical binding]; other site 566546014067 Q-loop/lid; other site 566546014068 ABC transporter signature motif; other site 566546014069 Walker B; other site 566546014070 D-loop; other site 566546014071 H-loop/switch region; other site 566546014072 ABC transporter; Region: ABC_tran_2; pfam12848 566546014073 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 566546014074 lytic murein transglycosylase; Provisional; Region: PRK11619 566546014075 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 566546014076 N-acetyl-D-glucosamine binding site [chemical binding]; other site 566546014077 catalytic residue [active] 566546014078 Trp operon repressor; Provisional; Region: PRK01381 566546014079 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 566546014080 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 566546014081 catalytic core [active] 566546014082 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 566546014083 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 566546014084 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 566546014085 hypothetical protein; Provisional; Region: PRK10756 566546014086 CreA protein; Region: CreA; pfam05981 566546014087 DNA-binding response regulator CreB; Provisional; Region: PRK11083 566546014088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546014089 active site 566546014090 phosphorylation site [posttranslational modification] 566546014091 intermolecular recognition site; other site 566546014092 dimerization interface [polypeptide binding]; other site 566546014093 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 566546014094 DNA binding site [nucleotide binding] 566546014095 sensory histidine kinase CreC; Provisional; Region: PRK11100 566546014096 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 566546014097 dimerization interface [polypeptide binding]; other site 566546014098 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 566546014099 dimer interface [polypeptide binding]; other site 566546014100 phosphorylation site [posttranslational modification] 566546014101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 566546014102 ATP binding site [chemical binding]; other site 566546014103 Mg2+ binding site [ion binding]; other site 566546014104 G-X-G motif; other site 566546014105 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 566546014106 two-component response regulator; Provisional; Region: PRK11173 566546014107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 566546014108 active site 566546014109 phosphorylation site [posttranslational modification] 566546014110 intermolecular recognition site; other site 566546014111 dimerization interface [polypeptide binding]; other site 566546014112 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 566546014113 DNA binding site [nucleotide binding] 566546014114 putative RNA methyltransferase; Provisional; Region: PRK10433 566546014115 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 566546014116 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 566546014117 AAA domain; Region: AAA_21; pfam13304 566546014118 Walker A/P-loop; other site 566546014119 ATP binding site [chemical binding]; other site 566546014120 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 566546014121 ATP binding site [chemical binding]; other site 566546014122 Q-loop/lid; other site 566546014123 ABC transporter signature motif; other site 566546014124 Walker B; other site 566546014125 D-loop; other site 566546014126 H-loop/switch region; other site 566546014127 Rop protein; Region: Rop; pfam01815 566546014128 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 566546014129 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 566546014130 MbeB-like, N-term conserved region; Region: MbeB_N; pfam04837 566546014131 MbeD/MobD like; Region: MbeD_MobD; pfam04899 566546014132 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 566546014133 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 566546014134 dimer interface [polypeptide binding]; other site 566546014135 ssDNA binding site [nucleotide binding]; other site 566546014136 tetramer (dimer of dimers) interface [polypeptide binding]; other site 566546014137 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 566546014138 ParB-like nuclease domain; Region: ParBc; pfam02195 566546014139 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 566546014140 plasmid SOS inhibition protein B; Provisional; Region: psiB; PRK13701 566546014141 PsiA protein; Region: PsiA; cl11646 566546014142 Antirestriction protein (ArdA); Region: ArdA; pfam07275 566546014143 putative transposase OrfB; Reviewed; Region: PHA02517 566546014144 HTH-like domain; Region: HTH_21; pfam13276 566546014145 Integrase core domain; Region: rve; pfam00665 566546014146 Integrase core domain; Region: rve_2; pfam13333 566546014147 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 566546014148 Helix-turn-helix domain; Region: HTH_28; pfam13518 566546014149 Helix-turn-helix domain; Region: HTH_28; pfam13518 566546014150 putative transposase; Provisional; Region: PRK09857 566546014151 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 566546014152 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 566546014153 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 566546014154 non-specific DNA binding site [nucleotide binding]; other site 566546014155 salt bridge; other site 566546014156 sequence-specific DNA binding site [nucleotide binding]; other site 566546014157 Methyltransferase domain; Region: Methyltransf_27; pfam13708 566546014158 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 566546014159 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 566546014160 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 566546014161 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 566546014162 dimerization domain [polypeptide binding]; other site 566546014163 dimer interface [polypeptide binding]; other site 566546014164 catalytic residues [active] 566546014165 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 566546014166 indole-3-acetamide amidohydrolase; Region: PLN02722 566546014167 AAA-like domain; Region: AAA_10; pfam12846 566546014168 Protein of unknown function (DUF3625); Region: DUF3625; pfam12293 566546014169 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 566546014170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 566546014171 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 566546014172 active site 566546014173 metal binding site [ion binding]; metal-binding site 566546014174 interdomain interaction site; other site 566546014175 conjugal transfer relaxase TraI; Provisional; Region: PRK13878 566546014176 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 566546014177 PLD-like domain; Region: PLDc_2; pfam13091 566546014178 putative active site [active] 566546014179 catalytic site [active] 566546014180 plasmid transfer ATPase TraJ; Region: plasmid_TraJ; TIGR02525 566546014181 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 566546014182 Walker A motif; other site 566546014183 ATP binding site [chemical binding]; other site 566546014184 Walker B motif; other site 566546014185 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 566546014186 catalytic core [active] 566546014187 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 566546014188 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 566546014189 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 566546014190 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 566546014191 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 566546014192 N-acetyl-D-glucosamine binding site [chemical binding]; other site 566546014193 catalytic residue [active] 566546014194 PilS N terminal; Region: PilS; pfam08805 566546014195 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 566546014196 Type II/IV secretion system protein; Region: T2SE; pfam00437 566546014197 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 566546014198 Walker A motif; other site 566546014199 ATP binding site [chemical binding]; other site 566546014200 Walker B motif; other site 566546014201 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 566546014202 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 566546014203 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 566546014204 Secretin N-terminal domain; Region: Secretin_N_2; pfam07655 566546014205 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 566546014206 PilM; Region: PilM; pfam07419 566546014207 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 566546014208 Plasmid conjugative transfer protein PilI; Region: PilI; pfam10623 566546014209 Protein of unknown function (DUF2913); Region: DUF2913; pfam11140 566546014210 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 566546014211 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 566546014212 IncFII RepA protein family; Region: IncFII_repA; cl11495 566546014213 Predicted transcriptional regulator [Transcription]; Region: COG3905 566546014214 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 566546014215 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 566546014216 putative kissing complex interaction region; other site 566546014217 putative RNA binding sites [nucleotide binding]; other site 566546014218 pseudogene, truncated colicin protein 566546014219 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 566546014220 Putative transposase; Region: Y2_Tnp; pfam04986 566546014221 Adhesin biosynthesis transcription regulatory protein; Region: PapB; cl04012 566546014222 fimbrial outer membrane usher protein PefC; Provisional; Region: PRK15213 566546014223 PapC N-terminal domain; Region: PapC_N; pfam13954 566546014224 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 566546014225 PapC C-terminal domain; Region: PapC_C; pfam13953 566546014226 fimbrial chaperone protein PefD; Provisional; Region: PRK15211 566546014227 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 566546014228 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 566546014229 Fimbrial, major and minor subunit; Region: Fimbrial_K88; pfam02432 566546014230 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 566546014231 Phage terminase small subunit; Region: Phage_terminase; pfam10668 566546014232 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 566546014233 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 566546014234 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 566546014235 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 566546014236 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 566546014237 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 566546014238 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 566546014239 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 566546014240 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 566546014241 Phage integrase family; Region: Phage_integrase; pfam00589 566546014242 active site 566546014243 DNA binding site [nucleotide binding] 566546014244 Int/Topo IB signature motif; other site 566546014245 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 566546014246 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 566546014247 P-loop; other site 566546014248 Magnesium ion binding site [ion binding]; other site 566546014249 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 566546014250 Mg binding site [ion binding]; other site 566546014251 nucleotide binding site [chemical binding]; other site 566546014252 putative protofilament interface [polypeptide binding]; other site 566546014253 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 566546014254 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 566546014255 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 566546014256 active site 566546014257 DNA binding site [nucleotide binding] 566546014258 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 566546014259 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 566546014260 Catalytic site [active] 566546014261 DinI-like family; Region: DinI; pfam06183 566546014262 Protein of unknown function (DUF1281); Region: DUF1281; pfam06924 566546014263 putative methylase; Provisional; Region: PRK13699 566546014264 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 566546014265 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 566546014266 Antirestriction protein; Region: Antirestrict; pfam03230 566546014267 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128