-- dump date 20140619_080933 -- class Genbank::misc_feature -- table misc_feature_note -- id note 885275000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 885275000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 885275000003 putative catalytic residues [active] 885275000004 putative nucleotide binding site [chemical binding]; other site 885275000005 putative aspartate binding site [chemical binding]; other site 885275000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 885275000007 dimer interface [polypeptide binding]; other site 885275000008 putative threonine allosteric regulatory site; other site 885275000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 885275000010 putative threonine allosteric regulatory site; other site 885275000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 885275000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 885275000013 homoserine kinase; Region: thrB; TIGR00191 885275000014 Protein of unknown function; Region: YhfT; pfam10797 885275000015 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 885275000016 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 885275000017 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 885275000018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275000019 catalytic residue [active] 885275000020 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 885275000021 hypothetical protein; Validated; Region: PRK02101 885275000022 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 885275000023 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 885275000024 transaldolase-like protein; Provisional; Region: PTZ00411 885275000025 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 885275000026 active site 885275000027 dimer interface [polypeptide binding]; other site 885275000028 catalytic residue [active] 885275000029 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 885275000030 MPT binding site; other site 885275000031 trimer interface [polypeptide binding]; other site 885275000032 hypothetical protein; Provisional; Region: PRK10659 885275000033 hypothetical protein; Provisional; Region: PRK10236 885275000034 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 885275000035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 885275000036 hypothetical protein; Provisional; Region: PRK10154 885275000037 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 885275000038 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 885275000039 nucleotide binding site [chemical binding]; other site 885275000040 NEF interaction site [polypeptide binding]; other site 885275000041 SBD interface [polypeptide binding]; other site 885275000042 chaperone protein DnaJ; Provisional; Region: PRK10767 885275000043 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 885275000044 HSP70 interaction site [polypeptide binding]; other site 885275000045 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 885275000046 substrate binding site [polypeptide binding]; other site 885275000047 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 885275000048 Zn binding sites [ion binding]; other site 885275000049 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 885275000050 dimer interface [polypeptide binding]; other site 885275000051 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 885275000052 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 885275000053 Sulfatase; Region: Sulfatase; pfam00884 885275000054 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 885275000055 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 885275000056 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275000057 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 885275000058 putative dimerization interface [polypeptide binding]; other site 885275000059 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 885275000060 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 885275000061 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 885275000062 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 885275000063 active site 885275000064 Riboflavin kinase; Region: Flavokinase; smart00904 885275000065 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 885275000066 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 885275000067 HIGH motif; other site 885275000068 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 885275000069 active site 885275000070 KMSKS motif; other site 885275000071 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 885275000072 tRNA binding surface [nucleotide binding]; other site 885275000073 anticodon binding site; other site 885275000074 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 885275000075 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 885275000076 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 885275000077 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 885275000078 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 885275000079 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 885275000080 Protein of unknown function (DUF805); Region: DUF805; pfam05656 885275000081 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 885275000082 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 885275000083 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 885275000084 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 885275000085 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 885275000086 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 885275000087 catalytic site [active] 885275000088 subunit interface [polypeptide binding]; other site 885275000089 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 885275000090 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 885275000091 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 885275000092 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 885275000093 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 885275000094 ATP-grasp domain; Region: ATP-grasp_4; cl17255 885275000095 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 885275000096 IMP binding site; other site 885275000097 dimer interface [polypeptide binding]; other site 885275000098 interdomain contacts; other site 885275000099 partial ornithine binding site; other site 885275000100 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 885275000101 carnitine operon protein CaiE; Provisional; Region: PRK13627 885275000102 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 885275000103 putative trimer interface [polypeptide binding]; other site 885275000104 putative metal binding site [ion binding]; other site 885275000105 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 885275000106 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 885275000107 substrate binding site [chemical binding]; other site 885275000108 oxyanion hole (OAH) forming residues; other site 885275000109 trimer interface [polypeptide binding]; other site 885275000110 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 885275000111 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 885275000112 acyl-activating enzyme (AAE) consensus motif; other site 885275000113 putative AMP binding site [chemical binding]; other site 885275000114 putative active site [active] 885275000115 putative CoA binding site [chemical binding]; other site 885275000116 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 885275000117 CoA-transferase family III; Region: CoA_transf_3; pfam02515 885275000118 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 885275000119 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 885275000120 active site 885275000121 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 885275000122 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 885275000123 Ligand binding site [chemical binding]; other site 885275000124 Electron transfer flavoprotein domain; Region: ETF; pfam01012 885275000125 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 885275000126 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 885275000127 Ligand binding site [chemical binding]; other site 885275000128 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 885275000129 putative oxidoreductase FixC; Provisional; Region: PRK10157 885275000130 ferredoxin-like protein FixX; Provisional; Region: PRK15449 885275000131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275000132 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 885275000133 putative substrate translocation pore; other site 885275000134 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 885275000135 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 885275000136 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 885275000137 TrkA-N domain; Region: TrkA_N; pfam02254 885275000138 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 885275000139 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 885275000140 folate binding site [chemical binding]; other site 885275000141 NADP+ binding site [chemical binding]; other site 885275000142 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 885275000143 CcdB protein; Region: CcdB; pfam01845 885275000144 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 885275000145 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 885275000146 active site 885275000147 metal binding site [ion binding]; metal-binding site 885275000148 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 885275000149 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 885275000150 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 885275000151 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 885275000152 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 885275000153 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 885275000154 SurA N-terminal domain; Region: SurA_N; pfam09312 885275000155 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 885275000156 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 885275000157 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 885275000158 OstA-like protein; Region: OstA; pfam03968 885275000159 Organic solvent tolerance protein; Region: OstA_C; pfam04453 885275000160 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 885275000161 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 885275000162 putative metal binding site [ion binding]; other site 885275000163 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 885275000164 HSP70 interaction site [polypeptide binding]; other site 885275000165 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 885275000166 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 885275000167 active site 885275000168 ATP-dependent helicase HepA; Validated; Region: PRK04914 885275000169 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 885275000170 ATP binding site [chemical binding]; other site 885275000171 putative Mg++ binding site [ion binding]; other site 885275000172 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 885275000173 nucleotide binding region [chemical binding]; other site 885275000174 ATP-binding site [chemical binding]; other site 885275000175 DNA polymerase II; Reviewed; Region: PRK05762 885275000176 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 885275000177 active site 885275000178 catalytic site [active] 885275000179 substrate binding site [chemical binding]; other site 885275000180 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 885275000181 active site 885275000182 metal-binding site 885275000183 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 885275000184 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 885275000185 intersubunit interface [polypeptide binding]; other site 885275000186 active site 885275000187 Zn2+ binding site [ion binding]; other site 885275000188 L-arabinose isomerase; Provisional; Region: PRK02929 885275000189 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 885275000190 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 885275000191 trimer interface [polypeptide binding]; other site 885275000192 putative substrate binding site [chemical binding]; other site 885275000193 putative metal binding site [ion binding]; other site 885275000194 ribulokinase; Provisional; Region: PRK04123 885275000195 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 885275000196 N- and C-terminal domain interface [polypeptide binding]; other site 885275000197 active site 885275000198 MgATP binding site [chemical binding]; other site 885275000199 catalytic site [active] 885275000200 metal binding site [ion binding]; metal-binding site 885275000201 carbohydrate binding site [chemical binding]; other site 885275000202 homodimer interface [polypeptide binding]; other site 885275000203 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 885275000204 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 885275000205 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275000206 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275000207 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 885275000208 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 885275000209 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 885275000210 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 885275000211 Walker A/P-loop; other site 885275000212 ATP binding site [chemical binding]; other site 885275000213 Q-loop/lid; other site 885275000214 ABC transporter signature motif; other site 885275000215 Walker B; other site 885275000216 D-loop; other site 885275000217 H-loop/switch region; other site 885275000218 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 885275000219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275000220 dimer interface [polypeptide binding]; other site 885275000221 conserved gate region; other site 885275000222 putative PBP binding loops; other site 885275000223 ABC-ATPase subunit interface; other site 885275000224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275000225 dimer interface [polypeptide binding]; other site 885275000226 conserved gate region; other site 885275000227 putative PBP binding loops; other site 885275000228 ABC-ATPase subunit interface; other site 885275000229 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 885275000230 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 885275000231 transcriptional regulator SgrR; Provisional; Region: PRK13626 885275000232 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 885275000233 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 885275000234 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 885275000235 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 885275000236 substrate binding site [chemical binding]; other site 885275000237 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 885275000238 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 885275000239 substrate binding site [chemical binding]; other site 885275000240 ligand binding site [chemical binding]; other site 885275000241 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 885275000242 tartrate dehydrogenase; Region: TTC; TIGR02089 885275000243 2-isopropylmalate synthase; Validated; Region: PRK00915 885275000244 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 885275000245 active site 885275000246 catalytic residues [active] 885275000247 metal binding site [ion binding]; metal-binding site 885275000248 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 885275000249 leu operon leader peptide; Provisional; Region: PRK09925 885275000250 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 885275000251 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275000252 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 885275000253 putative substrate binding pocket [chemical binding]; other site 885275000254 putative dimerization interface [polypeptide binding]; other site 885275000255 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 885275000256 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 885275000257 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 885275000258 PYR/PP interface [polypeptide binding]; other site 885275000259 dimer interface [polypeptide binding]; other site 885275000260 TPP binding site [chemical binding]; other site 885275000261 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 885275000262 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 885275000263 TPP-binding site [chemical binding]; other site 885275000264 dimer interface [polypeptide binding]; other site 885275000265 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 885275000266 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 885275000267 putative valine binding site [chemical binding]; other site 885275000268 dimer interface [polypeptide binding]; other site 885275000269 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 885275000270 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 885275000271 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 885275000272 DNA binding site [nucleotide binding] 885275000273 domain linker motif; other site 885275000274 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 885275000275 dimerization interface [polypeptide binding]; other site 885275000276 ligand binding site [chemical binding]; other site 885275000277 mraZ protein; Region: TIGR00242 885275000278 MraZ protein; Region: MraZ; pfam02381 885275000279 MraZ protein; Region: MraZ; pfam02381 885275000280 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 885275000281 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 885275000282 cell division protein FtsL; Provisional; Region: PRK10772 885275000283 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 885275000284 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 885275000285 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 885275000286 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 885275000287 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 885275000288 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 885275000289 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 885275000290 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 885275000291 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 885275000292 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 885275000293 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 885275000294 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 885275000295 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 885275000296 Mg++ binding site [ion binding]; other site 885275000297 putative catalytic motif [active] 885275000298 putative substrate binding site [chemical binding]; other site 885275000299 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 885275000300 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 885275000301 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 885275000302 cell division protein FtsW; Provisional; Region: PRK10774 885275000303 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 885275000304 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 885275000305 active site 885275000306 homodimer interface [polypeptide binding]; other site 885275000307 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 885275000308 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 885275000309 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 885275000310 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 885275000311 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 885275000312 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 885275000313 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 885275000314 cell division protein FtsQ; Provisional; Region: PRK10775 885275000315 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 885275000316 Cell division protein FtsQ; Region: FtsQ; pfam03799 885275000317 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 885275000318 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 885275000319 Cell division protein FtsA; Region: FtsA; pfam14450 885275000320 cell division protein FtsZ; Validated; Region: PRK09330 885275000321 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 885275000322 nucleotide binding site [chemical binding]; other site 885275000323 SulA interaction site; other site 885275000324 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 885275000325 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 885275000326 SecA regulator SecM; Provisional; Region: PRK02943 885275000327 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 885275000328 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 885275000329 SEC-C motif; Region: SEC-C; pfam02810 885275000330 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 885275000331 active site 885275000332 8-oxo-dGMP binding site [chemical binding]; other site 885275000333 nudix motif; other site 885275000334 metal binding site [ion binding]; metal-binding site 885275000335 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 885275000336 Helix-turn-helix domain; Region: HTH_28; pfam13518 885275000337 Helix-turn-helix domain; Region: HTH_28; pfam13518 885275000338 HTH-like domain; Region: HTH_21; pfam13276 885275000339 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 885275000340 Integrase core domain; Region: rve; pfam00665 885275000341 Integrase core domain; Region: rve_2; pfam13333 885275000342 DNA gyrase inhibitor; Reviewed; Region: PRK00418 885275000343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 885275000344 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 885275000345 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 885275000346 CoA-binding site [chemical binding]; other site 885275000347 ATP-binding [chemical binding]; other site 885275000348 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 885275000349 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 885275000350 active site 885275000351 type IV pilin biogenesis protein; Provisional; Region: PRK10573 885275000352 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 885275000353 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 885275000354 hypothetical protein; Provisional; Region: PRK10436 885275000355 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 885275000356 Walker A motif; other site 885275000357 ATP binding site [chemical binding]; other site 885275000358 Walker B motif; other site 885275000359 putative major pilin subunit; Provisional; Region: PRK10574 885275000360 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 885275000361 Pilin (bacterial filament); Region: Pilin; pfam00114 885275000362 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 885275000363 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 885275000364 dimerization interface [polypeptide binding]; other site 885275000365 active site 885275000366 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 885275000367 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 885275000368 amidase catalytic site [active] 885275000369 Zn binding residues [ion binding]; other site 885275000370 substrate binding site [chemical binding]; other site 885275000371 regulatory protein AmpE; Provisional; Region: PRK10987 885275000372 aromatic amino acid transporter; Provisional; Region: PRK10238 885275000373 Protein of unknown function (DUF796); Region: DUF796; cl01226 885275000374 S-type Pyocin; Region: Pyocin_S; pfam06958 885275000375 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 885275000376 active site 885275000377 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 885275000378 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 885275000379 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 885275000380 Transcriptional regulators [Transcription]; Region: FadR; COG2186 885275000381 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885275000382 DNA-binding site [nucleotide binding]; DNA binding site 885275000383 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 885275000384 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 885275000385 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 885275000386 dimer interface [polypeptide binding]; other site 885275000387 TPP-binding site [chemical binding]; other site 885275000388 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 885275000389 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 885275000390 E3 interaction surface; other site 885275000391 lipoyl attachment site [posttranslational modification]; other site 885275000392 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 885275000393 E3 interaction surface; other site 885275000394 lipoyl attachment site [posttranslational modification]; other site 885275000395 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 885275000396 E3 interaction surface; other site 885275000397 lipoyl attachment site [posttranslational modification]; other site 885275000398 e3 binding domain; Region: E3_binding; pfam02817 885275000399 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 885275000400 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 885275000401 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 885275000402 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 885275000403 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 885275000404 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 885275000405 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 885275000406 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 885275000407 substrate binding site [chemical binding]; other site 885275000408 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 885275000409 substrate binding site [chemical binding]; other site 885275000410 ligand binding site [chemical binding]; other site 885275000411 hypothetical protein; Provisional; Region: PRK05248 885275000412 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 885275000413 spermidine synthase; Provisional; Region: PRK00811 885275000414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275000415 S-adenosylmethionine binding site [chemical binding]; other site 885275000416 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 885275000417 multicopper oxidase; Provisional; Region: PRK10965 885275000418 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 885275000419 Multicopper oxidase; Region: Cu-oxidase; pfam00394 885275000420 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 885275000421 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 885275000422 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 885275000423 Trp docking motif [polypeptide binding]; other site 885275000424 putative active site [active] 885275000425 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 885275000426 active site 885275000427 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 885275000428 active site clefts [active] 885275000429 zinc binding site [ion binding]; other site 885275000430 dimer interface [polypeptide binding]; other site 885275000431 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 885275000432 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 885275000433 Walker A/P-loop; other site 885275000434 ATP binding site [chemical binding]; other site 885275000435 Q-loop/lid; other site 885275000436 ABC transporter signature motif; other site 885275000437 Walker B; other site 885275000438 D-loop; other site 885275000439 H-loop/switch region; other site 885275000440 inner membrane transport permease; Provisional; Region: PRK15066 885275000441 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 885275000442 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 885275000443 active pocket/dimerization site; other site 885275000444 active site 885275000445 phosphorylation site [posttranslational modification] 885275000446 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 885275000447 putative active site [active] 885275000448 putative metal binding site [ion binding]; other site 885275000449 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 885275000450 tetramerization interface [polypeptide binding]; other site 885275000451 active site 885275000452 Uncharacterized conserved protein [Function unknown]; Region: COG5464 885275000453 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 885275000454 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 885275000455 pantoate--beta-alanine ligase; Region: panC; TIGR00018 885275000456 Pantoate-beta-alanine ligase; Region: PanC; cd00560 885275000457 active site 885275000458 ATP-binding site [chemical binding]; other site 885275000459 pantoate-binding site; other site 885275000460 HXXH motif; other site 885275000461 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 885275000462 oligomerization interface [polypeptide binding]; other site 885275000463 active site 885275000464 metal binding site [ion binding]; metal-binding site 885275000465 putative fimbrial-like adhesin protein; Provisional; Region: PRK09723 885275000466 putative fimbrial protein StaF; Provisional; Region: PRK15262 885275000467 putative fimbrial protein StaE; Provisional; Region: PRK15263 885275000468 Fimbrial protein; Region: Fimbrial; cl01416 885275000469 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 885275000470 PapC N-terminal domain; Region: PapC_N; pfam13954 885275000471 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 885275000472 PapC C-terminal domain; Region: PapC_C; pfam13953 885275000473 putative chaperone protein EcpD; Provisional; Region: PRK09926 885275000474 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 885275000475 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 885275000476 Fimbrial protein; Region: Fimbrial; cl01416 885275000477 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 885275000478 catalytic center binding site [active] 885275000479 ATP binding site [chemical binding]; other site 885275000480 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 885275000481 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 885275000482 active site 885275000483 NTP binding site [chemical binding]; other site 885275000484 metal binding triad [ion binding]; metal-binding site 885275000485 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 885275000486 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 885275000487 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 885275000488 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 885275000489 active site 885275000490 nucleotide binding site [chemical binding]; other site 885275000491 HIGH motif; other site 885275000492 KMSKS motif; other site 885275000493 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 885275000494 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 885275000495 2'-5' RNA ligase; Provisional; Region: PRK15124 885275000496 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 885275000497 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 885275000498 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 885275000499 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 885275000500 ATP binding site [chemical binding]; other site 885275000501 putative Mg++ binding site [ion binding]; other site 885275000502 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 885275000503 nucleotide binding region [chemical binding]; other site 885275000504 ATP-binding site [chemical binding]; other site 885275000505 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 885275000506 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 885275000507 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 885275000508 Transglycosylase; Region: Transgly; pfam00912 885275000509 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 885275000510 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 885275000511 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885275000512 N-terminal plug; other site 885275000513 ligand-binding site [chemical binding]; other site 885275000514 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 885275000515 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 885275000516 Walker A/P-loop; other site 885275000517 ATP binding site [chemical binding]; other site 885275000518 Q-loop/lid; other site 885275000519 ABC transporter signature motif; other site 885275000520 Walker B; other site 885275000521 D-loop; other site 885275000522 H-loop/switch region; other site 885275000523 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 885275000524 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 885275000525 siderophore binding site; other site 885275000526 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 885275000527 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 885275000528 ABC-ATPase subunit interface; other site 885275000529 dimer interface [polypeptide binding]; other site 885275000530 putative PBP binding regions; other site 885275000531 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 885275000532 ABC-ATPase subunit interface; other site 885275000533 dimer interface [polypeptide binding]; other site 885275000534 putative PBP binding regions; other site 885275000535 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 885275000536 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 885275000537 inhibitor-cofactor binding pocket; inhibition site 885275000538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275000539 catalytic residue [active] 885275000540 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 885275000541 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 885275000542 Cl- selectivity filter; other site 885275000543 Cl- binding residues [ion binding]; other site 885275000544 pore gating glutamate residue; other site 885275000545 dimer interface [polypeptide binding]; other site 885275000546 H+/Cl- coupling transport residue; other site 885275000547 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 885275000548 hypothetical protein; Provisional; Region: PRK10578 885275000549 UPF0126 domain; Region: UPF0126; pfam03458 885275000550 UPF0126 domain; Region: UPF0126; pfam03458 885275000551 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 885275000552 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 885275000553 cobalamin binding residues [chemical binding]; other site 885275000554 putative BtuC binding residues; other site 885275000555 dimer interface [polypeptide binding]; other site 885275000556 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 885275000557 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 885275000558 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 885275000559 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 885275000560 Zn2+ binding site [ion binding]; other site 885275000561 Mg2+ binding site [ion binding]; other site 885275000562 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 885275000563 serine endoprotease; Provisional; Region: PRK10942 885275000564 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 885275000565 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 885275000566 protein binding site [polypeptide binding]; other site 885275000567 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 885275000568 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 885275000569 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 885275000570 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 885275000571 hypothetical protein; Provisional; Region: PRK13677 885275000572 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 885275000573 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 885275000574 trimer interface [polypeptide binding]; other site 885275000575 active site 885275000576 substrate binding site [chemical binding]; other site 885275000577 CoA binding site [chemical binding]; other site 885275000578 PII uridylyl-transferase; Provisional; Region: PRK05007 885275000579 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 885275000580 metal binding triad; other site 885275000581 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 885275000582 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 885275000583 Zn2+ binding site [ion binding]; other site 885275000584 Mg2+ binding site [ion binding]; other site 885275000585 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 885275000586 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 885275000587 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 885275000588 active site 885275000589 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 885275000590 rRNA interaction site [nucleotide binding]; other site 885275000591 S8 interaction site; other site 885275000592 putative laminin-1 binding site; other site 885275000593 elongation factor Ts; Provisional; Region: tsf; PRK09377 885275000594 UBA/TS-N domain; Region: UBA; pfam00627 885275000595 Elongation factor TS; Region: EF_TS; pfam00889 885275000596 Elongation factor TS; Region: EF_TS; pfam00889 885275000597 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 885275000598 putative nucleotide binding site [chemical binding]; other site 885275000599 uridine monophosphate binding site [chemical binding]; other site 885275000600 homohexameric interface [polypeptide binding]; other site 885275000601 ribosome recycling factor; Reviewed; Region: frr; PRK00083 885275000602 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 885275000603 hinge region; other site 885275000604 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 885275000605 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 885275000606 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 885275000607 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 885275000608 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 885275000609 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 885275000610 catalytic residue [active] 885275000611 putative FPP diphosphate binding site; other site 885275000612 putative FPP binding hydrophobic cleft; other site 885275000613 dimer interface [polypeptide binding]; other site 885275000614 putative IPP diphosphate binding site; other site 885275000615 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 885275000616 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 885275000617 zinc metallopeptidase RseP; Provisional; Region: PRK10779 885275000618 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 885275000619 active site 885275000620 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 885275000621 protein binding site [polypeptide binding]; other site 885275000622 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 885275000623 putative substrate binding region [chemical binding]; other site 885275000624 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 885275000625 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 885275000626 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 885275000627 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 885275000628 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 885275000629 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 885275000630 Surface antigen; Region: Bac_surface_Ag; pfam01103 885275000631 periplasmic chaperone; Provisional; Region: PRK10780 885275000632 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 885275000633 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 885275000634 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 885275000635 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 885275000636 trimer interface [polypeptide binding]; other site 885275000637 active site 885275000638 UDP-GlcNAc binding site [chemical binding]; other site 885275000639 lipid binding site [chemical binding]; lipid-binding site 885275000640 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 885275000641 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 885275000642 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 885275000643 active site 885275000644 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 885275000645 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 885275000646 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 885275000647 RNA/DNA hybrid binding site [nucleotide binding]; other site 885275000648 active site 885275000649 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 885275000650 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 885275000651 putative active site [active] 885275000652 putative PHP Thumb interface [polypeptide binding]; other site 885275000653 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 885275000654 generic binding surface II; other site 885275000655 generic binding surface I; other site 885275000656 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 885275000657 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 885275000658 lysine decarboxylase LdcC; Provisional; Region: PRK15399 885275000659 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 885275000660 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 885275000661 homodimer interface [polypeptide binding]; other site 885275000662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275000663 catalytic residue [active] 885275000664 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 885275000665 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 885275000666 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 885275000667 putative metal binding site [ion binding]; other site 885275000668 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 885275000669 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 885275000670 Ligand Binding Site [chemical binding]; other site 885275000671 TilS substrate binding domain; Region: TilS; pfam09179 885275000672 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 885275000673 Rho-binding antiterminator; Provisional; Region: PRK11625 885275000674 hypothetical protein; Provisional; Region: PRK04964 885275000675 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 885275000676 hypothetical protein; Provisional; Region: PRK09256 885275000677 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 885275000678 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 885275000679 NlpE N-terminal domain; Region: NlpE; pfam04170 885275000680 HTH-like domain; Region: HTH_21; pfam13276 885275000681 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 885275000682 Integrase core domain; Region: rve; pfam00665 885275000683 Integrase core domain; Region: rve_2; pfam13333 885275000684 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 885275000685 Helix-turn-helix domain; Region: HTH_28; pfam13518 885275000686 Helix-turn-helix domain; Region: HTH_28; pfam13518 885275000687 hypothetical protein; Provisional; Region: PRK11479 885275000688 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 885275000689 prolyl-tRNA synthetase; Provisional; Region: PRK09194 885275000690 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 885275000691 dimer interface [polypeptide binding]; other site 885275000692 motif 1; other site 885275000693 active site 885275000694 motif 2; other site 885275000695 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 885275000696 putative deacylase active site [active] 885275000697 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 885275000698 active site 885275000699 motif 3; other site 885275000700 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 885275000701 anticodon binding site; other site 885275000702 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 885275000703 homodimer interaction site [polypeptide binding]; other site 885275000704 cofactor binding site; other site 885275000705 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 885275000706 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 885275000707 lipoprotein, YaeC family; Region: TIGR00363 885275000708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275000709 dimer interface [polypeptide binding]; other site 885275000710 conserved gate region; other site 885275000711 ABC-ATPase subunit interface; other site 885275000712 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 885275000713 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 885275000714 Walker A/P-loop; other site 885275000715 ATP binding site [chemical binding]; other site 885275000716 Q-loop/lid; other site 885275000717 ABC transporter signature motif; other site 885275000718 Walker B; other site 885275000719 D-loop; other site 885275000720 H-loop/switch region; other site 885275000721 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 885275000722 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 885275000723 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885275000724 active site 885275000725 motif I; other site 885275000726 motif II; other site 885275000727 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 885275000728 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 885275000729 active site 885275000730 catalytic tetrad [active] 885275000731 Transcriptional regulator [Transcription]; Region: LysR; COG0583 885275000732 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275000733 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 885275000734 putative effector binding pocket; other site 885275000735 dimerization interface [polypeptide binding]; other site 885275000736 hypothetical protein; Provisional; Region: PRK05421 885275000737 putative catalytic site [active] 885275000738 putative metal binding site [ion binding]; other site 885275000739 putative phosphate binding site [ion binding]; other site 885275000740 putative catalytic site [active] 885275000741 putative phosphate binding site [ion binding]; other site 885275000742 putative metal binding site [ion binding]; other site 885275000743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275000744 S-adenosylmethionine binding site [chemical binding]; other site 885275000745 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 885275000746 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 885275000747 N-acetyl-D-glucosamine binding site [chemical binding]; other site 885275000748 catalytic residue [active] 885275000749 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 885275000750 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 885275000751 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 885275000752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275000753 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 885275000754 RNA/DNA hybrid binding site [nucleotide binding]; other site 885275000755 active site 885275000756 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 885275000757 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 885275000758 active site 885275000759 catalytic site [active] 885275000760 substrate binding site [chemical binding]; other site 885275000761 Methyltransferase domain; Region: Methyltransf_27; pfam13708 885275000762 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 885275000763 Transposase; Region: HTH_Tnp_1; pfam01527 885275000764 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 885275000765 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 885275000766 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 885275000767 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 885275000768 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 885275000769 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 885275000770 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 885275000771 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 885275000772 Transposase; Region: DEDD_Tnp_IS110; pfam01548 885275000773 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 885275000774 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 885275000775 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 885275000776 active site 885275000777 Int/Topo IB signature motif; other site 885275000778 BRO family, N-terminal domain; Region: Bro-N; cl10591 885275000779 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 885275000780 AAA domain; Region: AAA_25; pfam13481 885275000781 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 885275000782 Walker A motif; other site 885275000783 ATP binding site [chemical binding]; other site 885275000784 Walker B motif; other site 885275000785 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 885275000786 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 885275000787 ssDNA binding site [nucleotide binding]; other site 885275000788 dimer interface [polypeptide binding]; other site 885275000789 tetramer (dimer of dimers) interface [polypeptide binding]; other site 885275000790 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 885275000791 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 885275000792 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 885275000793 Transposase; Region: DEDD_Tnp_IS110; pfam01548 885275000794 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 885275000795 Homeodomain-like domain; Region: HTH_23; pfam13384 885275000796 Winged helix-turn helix; Region: HTH_29; pfam13551 885275000797 Homeodomain-like domain; Region: HTH_32; pfam13565 885275000798 DDE superfamily endonuclease; Region: DDE_3; pfam13358 885275000799 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 885275000800 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 885275000801 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 885275000802 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 885275000803 MPN+ (JAMM) motif; other site 885275000804 Zinc-binding site [ion binding]; other site 885275000805 potential frameshift: common BLAST hit: gi|218697845|ref|YP_002405512.1| antirestriction protein 885275000806 Antirestriction protein; Region: Antirestrict; pfam03230 885275000807 Domain of unknown function (DUF932); Region: DUF932; pfam06067 885275000808 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 885275000809 Photosystem II protein; Region: PSII; cl08223 885275000810 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 885275000811 nucleophile elbow; other site 885275000812 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 885275000813 YjcZ-like protein; Region: YjcZ; pfam13990 885275000814 hypothetical protein; Provisional; Region: PRK09866 885275000815 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 885275000816 G1 box; other site 885275000817 GTP/Mg2+ binding site [chemical binding]; other site 885275000818 G2 box; other site 885275000819 Switch I region; other site 885275000820 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 885275000821 G3 box; other site 885275000822 Switch II region; other site 885275000823 GTP/Mg2+ binding site [chemical binding]; other site 885275000824 G4 box; other site 885275000825 G5 box; other site 885275000826 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 885275000827 G1 box; other site 885275000828 GTP/Mg2+ binding site [chemical binding]; other site 885275000829 G2 box; other site 885275000830 Switch I region; other site 885275000831 Switch II region; other site 885275000832 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 885275000833 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 885275000834 active site 885275000835 DNA binding site [nucleotide binding] 885275000836 Int/Topo IB signature motif; other site 885275000837 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 885275000838 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885275000839 N-terminal plug; other site 885275000840 ligand-binding site [chemical binding]; other site 885275000841 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 885275000842 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 885275000843 putative ligand binding residues [chemical binding]; other site 885275000844 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 885275000845 dimer interface [polypeptide binding]; other site 885275000846 putative PBP binding regions; other site 885275000847 ABC-ATPase subunit interface; other site 885275000848 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 885275000849 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 885275000850 Walker A/P-loop; other site 885275000851 ATP binding site [chemical binding]; other site 885275000852 Q-loop/lid; other site 885275000853 ABC transporter signature motif; other site 885275000854 Walker B; other site 885275000855 D-loop; other site 885275000856 H-loop/switch region; other site 885275000857 Haemolysin expression modulating protein; Region: HHA; pfam05321 885275000858 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 885275000859 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 885275000860 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 885275000861 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 885275000862 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 885275000863 hypothetical protein; Provisional; Region: PRK09273 885275000864 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 885275000865 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 885275000866 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 885275000867 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 885275000868 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 885275000869 NADP binding site [chemical binding]; other site 885275000870 homodimer interface [polypeptide binding]; other site 885275000871 active site 885275000872 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 885275000873 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 885275000874 Right handed beta helix region; Region: Beta_helix; pfam13229 885275000875 CAAX protease self-immunity; Region: Abi; pfam02517 885275000876 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 885275000877 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 885275000878 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 885275000879 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 885275000880 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 885275000881 substrate binding site [chemical binding]; other site 885275000882 dimer interface [polypeptide binding]; other site 885275000883 ATP binding site [chemical binding]; other site 885275000884 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 885275000885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275000886 putative substrate translocation pore; other site 885275000887 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 885275000888 active site 885275000889 catalytic residues [active] 885275000890 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 885275000891 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 885275000892 active site 885275000893 P-loop; other site 885275000894 phosphorylation site [posttranslational modification] 885275000895 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 885275000896 active site 885275000897 phosphorylation site [posttranslational modification] 885275000898 Transcriptional regulators [Transcription]; Region: PurR; COG1609 885275000899 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 885275000900 DNA binding site [nucleotide binding] 885275000901 domain linker motif; other site 885275000902 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 885275000903 putative dimerization interface [polypeptide binding]; other site 885275000904 putative ligand binding site [chemical binding]; other site 885275000905 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 885275000906 haemagglutination activity domain; Region: Haemagg_act; pfam05860 885275000907 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 885275000908 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 885275000909 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 885275000910 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 885275000911 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 885275000912 MULE transposase domain; Region: MULE; pfam10551 885275000913 Adhesin biosynthesis transcription regulatory protein; Region: PapB; cl04012 885275000914 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 885275000915 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 885275000916 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 885275000917 Autotransporter beta-domain; Region: Autotransporter; pfam03797 885275000918 Transposase; Region: DDE_Tnp_ISL3; pfam01610 885275000919 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 885275000920 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 885275000921 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 885275000922 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 885275000923 putative active site [active] 885275000924 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 885275000925 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885275000926 Walker A/P-loop; other site 885275000927 ATP binding site [chemical binding]; other site 885275000928 Q-loop/lid; other site 885275000929 ABC transporter signature motif; other site 885275000930 Walker B; other site 885275000931 D-loop; other site 885275000932 H-loop/switch region; other site 885275000933 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 885275000934 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885275000935 HlyD family secretion protein; Region: HlyD_3; pfam13437 885275000936 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 885275000937 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 885275000938 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885275000939 DNA binding residues [nucleotide binding] 885275000940 dimerization interface [polypeptide binding]; other site 885275000941 potential frameshift: common BLAST hit: gi|110642861|ref|YP_670591.1| transposase 885275000942 DDE superfamily endonuclease; Region: DDE_3; pfam13358 885275000943 Homeodomain-like domain; Region: HTH_23; pfam13384 885275000944 Winged helix-turn helix; Region: HTH_29; pfam13551 885275000945 Winged helix-turn helix; Region: HTH_33; pfam13592 885275000946 integrating conjugative element protein, PFL_4695 family; Region: ICE_PFL_4695; TIGR03765 885275000947 C-N hydrolase family amidase; Provisional; Region: PRK10438 885275000948 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 885275000949 putative active site [active] 885275000950 catalytic triad [active] 885275000951 dimer interface [polypeptide binding]; other site 885275000952 multimer interface [polypeptide binding]; other site 885275000953 C-lysozyme inhibitor; Provisional; Region: PRK09993 885275000954 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 885275000955 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 885275000956 active site 885275000957 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 885275000958 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 885275000959 dimer interface [polypeptide binding]; other site 885275000960 active site 885275000961 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 885275000962 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 885275000963 putative active site [active] 885275000964 putative dimer interface [polypeptide binding]; other site 885275000965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 885275000966 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 885275000967 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 885275000968 NlpC/P60 family; Region: NLPC_P60; pfam00877 885275000969 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 885275000970 FHIPEP family; Region: FHIPEP; pfam00771 885275000971 hypothetical protein; Validated; Region: PRK06778 885275000972 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 885275000973 ligand binding site [chemical binding]; other site 885275000974 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 885275000975 active site 885275000976 DNA polymerase IV; Validated; Region: PRK02406 885275000977 DNA binding site [nucleotide binding] 885275000978 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 885275000979 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 885275000980 Coenzyme A binding pocket [chemical binding]; other site 885275000981 hypothetical protein; Reviewed; Region: PRK09588 885275000982 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 885275000983 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 885275000984 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 885275000985 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 885275000986 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 885275000987 metal binding site [ion binding]; metal-binding site 885275000988 dimer interface [polypeptide binding]; other site 885275000989 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 885275000990 active site 885275000991 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 885275000992 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 885275000993 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 885275000994 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 885275000995 trimer interface [polypeptide binding]; other site 885275000996 eyelet of channel; other site 885275000997 gamma-glutamyl kinase; Provisional; Region: PRK05429 885275000998 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 885275000999 nucleotide binding site [chemical binding]; other site 885275001000 homotetrameric interface [polypeptide binding]; other site 885275001001 putative phosphate binding site [ion binding]; other site 885275001002 putative allosteric binding site; other site 885275001003 PUA domain; Region: PUA; pfam01472 885275001004 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 885275001005 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 885275001006 putative catalytic cysteine [active] 885275001007 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 885275001008 MarR family; Region: MarR_2; cl17246 885275001009 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 885275001010 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 885275001011 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 885275001012 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 885275001013 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 885275001014 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 885275001015 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 885275001016 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 885275001017 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 885275001018 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 885275001019 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 885275001020 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885275001021 DNA binding residues [nucleotide binding] 885275001022 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 885275001023 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 885275001024 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 885275001025 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 885275001026 putative active site [active] 885275001027 putative FMN binding site [chemical binding]; other site 885275001028 putative substrate binding site [chemical binding]; other site 885275001029 putative catalytic residue [active] 885275001030 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 885275001031 Transcriptional regulator [Transcription]; Region: LysR; COG0583 885275001032 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275001033 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 885275001034 putative effector binding pocket; other site 885275001035 putative dimerization interface [polypeptide binding]; other site 885275001036 Transcriptional regulator [Transcription]; Region: LysR; COG0583 885275001037 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275001038 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 885275001039 putative effector binding pocket; other site 885275001040 putative dimerization interface [polypeptide binding]; other site 885275001041 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 885275001042 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 885275001043 active site 885275001044 catalytic tetrad [active] 885275001045 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 885275001046 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 885275001047 active site 885275001048 catalytic tetrad [active] 885275001049 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 885275001050 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 885275001051 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 885275001052 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 885275001053 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 885275001054 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 885275001055 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275001056 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 885275001057 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 885275001058 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 885275001059 active site 885275001060 catalytic tetrad [active] 885275001061 Predicted membrane protein [Function unknown]; Region: COG3059 885275001062 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 885275001063 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 885275001064 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 885275001065 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 885275001066 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 885275001067 Cupin; Region: Cupin_6; pfam12852 885275001068 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 885275001069 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275001070 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 885275001071 Cysteine-rich domain; Region: CCG; pfam02754 885275001072 Cysteine-rich domain; Region: CCG; pfam02754 885275001073 iron-sulfur cluster-binding protein; Region: TIGR00273 885275001074 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 885275001075 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 885275001076 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 885275001077 Uncharacterized conserved protein [Function unknown]; Region: COG1556 885275001078 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 885275001079 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 885275001080 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 885275001081 Autotransporter beta-domain; Region: Autotransporter; pfam03797 885275001082 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 885275001083 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885275001084 DNA binding residues [nucleotide binding] 885275001085 dimerization interface [polypeptide binding]; other site 885275001086 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 885275001087 active site 885275001088 DNA binding site [nucleotide binding] 885275001089 Int/Topo IB signature motif; other site 885275001090 choline dehydrogenase; Validated; Region: PRK02106 885275001091 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 885275001092 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 885275001093 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 885275001094 tetrameric interface [polypeptide binding]; other site 885275001095 NAD binding site [chemical binding]; other site 885275001096 catalytic residues [active] 885275001097 transcriptional regulator BetI; Validated; Region: PRK00767 885275001098 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 885275001099 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 885275001100 choline transport protein BetT; Provisional; Region: PRK09928 885275001101 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885275001102 DNA binding residues [nucleotide binding] 885275001103 dimerization interface [polypeptide binding]; other site 885275001104 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885275001105 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 885275001106 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275001107 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 885275001108 dimerization interface [polypeptide binding]; other site 885275001109 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 885275001110 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 885275001111 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 885275001112 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 885275001113 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 885275001114 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 885275001115 CoA binding domain; Region: CoA_binding; pfam02629 885275001116 CoA-ligase; Region: Ligase_CoA; pfam00549 885275001117 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 885275001118 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 885275001119 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 885275001120 putative substrate binding site [chemical binding]; other site 885275001121 nucleotide binding site [chemical binding]; other site 885275001122 nucleotide binding site [chemical binding]; other site 885275001123 homodimer interface [polypeptide binding]; other site 885275001124 putative deaminase; Validated; Region: PRK06846 885275001125 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 885275001126 active site 885275001127 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 885275001128 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 885275001129 putative NAD(P) binding site [chemical binding]; other site 885275001130 putative substrate binding site [chemical binding]; other site 885275001131 catalytic Zn binding site [ion binding]; other site 885275001132 structural Zn binding site [ion binding]; other site 885275001133 dimer interface [polypeptide binding]; other site 885275001134 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 885275001135 hypothetical protein; Provisional; Region: PRK09929 885275001136 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 885275001137 Propionate catabolism activator; Region: PrpR_N; pfam06506 885275001138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275001139 Walker A motif; other site 885275001140 ATP binding site [chemical binding]; other site 885275001141 Walker B motif; other site 885275001142 arginine finger; other site 885275001143 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 885275001144 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 885275001145 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 885275001146 tetramer interface [polypeptide binding]; other site 885275001147 active site 885275001148 Mg2+/Mn2+ binding site [ion binding]; other site 885275001149 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 885275001150 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 885275001151 dimer interface [polypeptide binding]; other site 885275001152 active site 885275001153 citrylCoA binding site [chemical binding]; other site 885275001154 oxalacetate/citrate binding site [chemical binding]; other site 885275001155 coenzyme A binding site [chemical binding]; other site 885275001156 catalytic triad [active] 885275001157 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 885275001158 2-methylcitrate dehydratase; Region: prpD; TIGR02330 885275001159 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 885275001160 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 885275001161 acyl-activating enzyme (AAE) consensus motif; other site 885275001162 putative AMP binding site [chemical binding]; other site 885275001163 putative active site [active] 885275001164 putative CoA binding site [chemical binding]; other site 885275001165 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 885275001166 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 885275001167 Na binding site [ion binding]; other site 885275001168 putative substrate binding site [chemical binding]; other site 885275001169 cytosine deaminase; Provisional; Region: PRK09230 885275001170 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 885275001171 active site 885275001172 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 885275001173 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 885275001174 active site 885275001175 substrate binding site [chemical binding]; other site 885275001176 trimer interface [polypeptide binding]; other site 885275001177 CoA binding site [chemical binding]; other site 885275001178 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 885275001179 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275001180 putative substrate translocation pore; other site 885275001181 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 885275001182 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 885275001183 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 885275001184 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 885275001185 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 885275001186 lac repressor; Reviewed; Region: lacI; PRK09526 885275001187 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 885275001188 DNA binding site [nucleotide binding] 885275001189 domain linker motif; other site 885275001190 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 885275001191 ligand binding site [chemical binding]; other site 885275001192 dimerization interface (open form) [polypeptide binding]; other site 885275001193 dimerization interface (closed form) [polypeptide binding]; other site 885275001194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 885275001195 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 885275001196 S-formylglutathione hydrolase; Region: PLN02442 885275001197 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 885275001198 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 885275001199 substrate binding site [chemical binding]; other site 885275001200 catalytic Zn binding site [ion binding]; other site 885275001201 NAD binding site [chemical binding]; other site 885275001202 structural Zn binding site [ion binding]; other site 885275001203 dimer interface [polypeptide binding]; other site 885275001204 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 885275001205 putative metal binding site [ion binding]; other site 885275001206 putative homodimer interface [polypeptide binding]; other site 885275001207 putative homotetramer interface [polypeptide binding]; other site 885275001208 putative homodimer-homodimer interface [polypeptide binding]; other site 885275001209 putative allosteric switch controlling residues; other site 885275001210 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 885275001211 putative trimer interface [polypeptide binding]; other site 885275001212 putative CoA binding site [chemical binding]; other site 885275001213 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 885275001214 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 885275001215 DXD motif; other site 885275001216 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 885275001217 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 885275001218 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 885275001219 substrate binding pocket [chemical binding]; other site 885275001220 membrane-bound complex binding site; other site 885275001221 hinge residues; other site 885275001222 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 885275001223 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 885275001224 Walker A/P-loop; other site 885275001225 ATP binding site [chemical binding]; other site 885275001226 Q-loop/lid; other site 885275001227 ABC transporter signature motif; other site 885275001228 Walker B; other site 885275001229 D-loop; other site 885275001230 H-loop/switch region; other site 885275001231 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 885275001232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275001233 dimer interface [polypeptide binding]; other site 885275001234 conserved gate region; other site 885275001235 putative PBP binding loops; other site 885275001236 ABC-ATPase subunit interface; other site 885275001237 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 885275001238 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 885275001239 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 885275001240 dimer interface [polypeptide binding]; other site 885275001241 active site 885275001242 Schiff base residues; other site 885275001243 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 885275001244 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 885275001245 Autotransporter beta-domain; Region: Autotransporter; pfam03797 885275001246 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 885275001247 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 885275001248 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 885275001249 microcin B17 transporter; Reviewed; Region: PRK11098 885275001250 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 885275001251 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 885275001252 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 885275001253 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 885275001254 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 885275001255 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 885275001256 anti-RssB factor; Provisional; Region: PRK10244 885275001257 alkaline phosphatase; Provisional; Region: PRK10518 885275001258 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 885275001259 dimer interface [polypeptide binding]; other site 885275001260 active site 885275001261 hypothetical protein; Provisional; Region: PRK11505 885275001262 psiF repeat; Region: PsiF_repeat; pfam07769 885275001263 psiF repeat; Region: PsiF_repeat; pfam07769 885275001264 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 885275001265 MASE2 domain; Region: MASE2; pfam05230 885275001266 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885275001267 metal binding site [ion binding]; metal-binding site 885275001268 active site 885275001269 I-site; other site 885275001270 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 885275001271 pyrroline-5-carboxylate reductase; Region: PLN02688 885275001272 hypothetical protein; Validated; Region: PRK00124 885275001273 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 885275001274 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 885275001275 ADP binding site [chemical binding]; other site 885275001276 magnesium binding site [ion binding]; other site 885275001277 putative shikimate binding site; other site 885275001278 hypothetical protein; Provisional; Region: PRK10380 885275001279 hypothetical protein; Provisional; Region: PRK10481 885275001280 hypothetical protein; Provisional; Region: PRK10579 885275001281 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 885275001282 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 885275001283 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 885275001284 fructokinase; Reviewed; Region: PRK09557 885275001285 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 885275001286 nucleotide binding site [chemical binding]; other site 885275001287 MFS transport protein AraJ; Provisional; Region: PRK10091 885275001288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275001289 putative substrate translocation pore; other site 885275001290 exonuclease subunit SbcC; Provisional; Region: PRK10246 885275001291 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885275001292 Walker A/P-loop; other site 885275001293 ATP binding site [chemical binding]; other site 885275001294 Q-loop/lid; other site 885275001295 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885275001296 ABC transporter signature motif; other site 885275001297 Walker B; other site 885275001298 D-loop; other site 885275001299 H-loop/switch region; other site 885275001300 exonuclease subunit SbcD; Provisional; Region: PRK10966 885275001301 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 885275001302 active site 885275001303 metal binding site [ion binding]; metal-binding site 885275001304 DNA binding site [nucleotide binding] 885275001305 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 885275001306 transcriptional regulator PhoB; Provisional; Region: PRK10161 885275001307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275001308 active site 885275001309 phosphorylation site [posttranslational modification] 885275001310 intermolecular recognition site; other site 885275001311 dimerization interface [polypeptide binding]; other site 885275001312 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 885275001313 DNA binding site [nucleotide binding] 885275001314 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 885275001315 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 885275001316 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 885275001317 putative active site [active] 885275001318 heme pocket [chemical binding]; other site 885275001319 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885275001320 dimer interface [polypeptide binding]; other site 885275001321 phosphorylation site [posttranslational modification] 885275001322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275001323 ATP binding site [chemical binding]; other site 885275001324 Mg2+ binding site [ion binding]; other site 885275001325 G-X-G motif; other site 885275001326 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 885275001327 putative proline-specific permease; Provisional; Region: proY; PRK10580 885275001328 Spore germination protein; Region: Spore_permease; cl17796 885275001329 maltodextrin glucosidase; Provisional; Region: PRK10785 885275001330 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 885275001331 homodimer interface [polypeptide binding]; other site 885275001332 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 885275001333 active site 885275001334 homodimer interface [polypeptide binding]; other site 885275001335 catalytic site [active] 885275001336 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 885275001337 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 885275001338 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 885275001339 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 885275001340 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 885275001341 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 885275001342 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 885275001343 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 885275001344 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 885275001345 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 885275001346 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 885275001347 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 885275001348 Protein export membrane protein; Region: SecD_SecF; pfam02355 885275001349 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 885275001350 active site 885275001351 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 885275001352 hypothetical protein; Provisional; Region: PRK11530 885275001353 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 885275001354 ATP cone domain; Region: ATP-cone; pfam03477 885275001355 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 885275001356 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 885275001357 catalytic motif [active] 885275001358 Zn binding site [ion binding]; other site 885275001359 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 885275001360 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 885275001361 homopentamer interface [polypeptide binding]; other site 885275001362 active site 885275001363 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 885275001364 putative RNA binding site [nucleotide binding]; other site 885275001365 thiamine monophosphate kinase; Provisional; Region: PRK05731 885275001366 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 885275001367 ATP binding site [chemical binding]; other site 885275001368 dimerization interface [polypeptide binding]; other site 885275001369 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 885275001370 tetramer interfaces [polypeptide binding]; other site 885275001371 binuclear metal-binding site [ion binding]; other site 885275001372 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 885275001373 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 885275001374 active site 885275001375 catalytic tetrad [active] 885275001376 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 885275001377 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 885275001378 TPP-binding site; other site 885275001379 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 885275001380 PYR/PP interface [polypeptide binding]; other site 885275001381 dimer interface [polypeptide binding]; other site 885275001382 TPP binding site [chemical binding]; other site 885275001383 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 885275001384 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 885275001385 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 885275001386 substrate binding pocket [chemical binding]; other site 885275001387 chain length determination region; other site 885275001388 substrate-Mg2+ binding site; other site 885275001389 catalytic residues [active] 885275001390 aspartate-rich region 1; other site 885275001391 active site lid residues [active] 885275001392 aspartate-rich region 2; other site 885275001393 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 885275001394 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 885275001395 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 885275001396 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 885275001397 Ligand Binding Site [chemical binding]; other site 885275001398 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 885275001399 active site residue [active] 885275001400 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 885275001401 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 885275001402 conserved cys residue [active] 885275001403 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 885275001404 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 885275001405 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 885275001406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 885275001407 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 885275001408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275001409 Major Facilitator Superfamily; Region: MFS_1; pfam07690 885275001410 putative substrate translocation pore; other site 885275001411 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 885275001412 UbiA prenyltransferase family; Region: UbiA; pfam01040 885275001413 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 885275001414 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 885275001415 Subunit I/III interface [polypeptide binding]; other site 885275001416 Subunit III/IV interface [polypeptide binding]; other site 885275001417 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 885275001418 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 885275001419 D-pathway; other site 885275001420 Putative ubiquinol binding site [chemical binding]; other site 885275001421 Low-spin heme (heme b) binding site [chemical binding]; other site 885275001422 Putative water exit pathway; other site 885275001423 Binuclear center (heme o3/CuB) [ion binding]; other site 885275001424 K-pathway; other site 885275001425 Putative proton exit pathway; other site 885275001426 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 885275001427 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 885275001428 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 885275001429 muropeptide transporter; Reviewed; Region: ampG; PRK11902 885275001430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275001431 putative substrate translocation pore; other site 885275001432 hypothetical protein; Provisional; Region: PRK11627 885275001433 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 885275001434 transcriptional regulator BolA; Provisional; Region: PRK11628 885275001435 trigger factor; Provisional; Region: tig; PRK01490 885275001436 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 885275001437 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 885275001438 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 885275001439 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 885275001440 oligomer interface [polypeptide binding]; other site 885275001441 active site residues [active] 885275001442 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 885275001443 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 885275001444 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275001445 Walker A motif; other site 885275001446 ATP binding site [chemical binding]; other site 885275001447 Walker B motif; other site 885275001448 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 885275001449 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 885275001450 Found in ATP-dependent protease La (LON); Region: LON; smart00464 885275001451 Found in ATP-dependent protease La (LON); Region: LON; smart00464 885275001452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275001453 Walker A motif; other site 885275001454 ATP binding site [chemical binding]; other site 885275001455 Walker B motif; other site 885275001456 arginine finger; other site 885275001457 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 885275001458 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 885275001459 IHF dimer interface [polypeptide binding]; other site 885275001460 IHF - DNA interface [nucleotide binding]; other site 885275001461 periplasmic folding chaperone; Provisional; Region: PRK10788 885275001462 SurA N-terminal domain; Region: SurA_N_3; cl07813 885275001463 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 885275001464 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 885275001465 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 885275001466 active site 885275001467 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 885275001468 Ligand Binding Site [chemical binding]; other site 885275001469 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 885275001470 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 885275001471 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 885275001472 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 885275001473 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885275001474 active site 885275001475 motif I; other site 885275001476 motif II; other site 885275001477 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 885275001478 dimerization interface [polypeptide binding]; other site 885275001479 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 885275001480 putative DNA binding site [nucleotide binding]; other site 885275001481 putative Zn2+ binding site [ion binding]; other site 885275001482 AsnC family; Region: AsnC_trans_reg; pfam01037 885275001483 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 885275001484 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 885275001485 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885275001486 Walker A/P-loop; other site 885275001487 ATP binding site [chemical binding]; other site 885275001488 Q-loop/lid; other site 885275001489 ABC transporter signature motif; other site 885275001490 Walker B; other site 885275001491 D-loop; other site 885275001492 H-loop/switch region; other site 885275001493 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 885275001494 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 885275001495 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 885275001496 Walker A/P-loop; other site 885275001497 ATP binding site [chemical binding]; other site 885275001498 Q-loop/lid; other site 885275001499 ABC transporter signature motif; other site 885275001500 Walker B; other site 885275001501 D-loop; other site 885275001502 H-loop/switch region; other site 885275001503 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 885275001504 Nitrogen regulatory protein P-II; Region: P-II; smart00938 885275001505 ammonium transporter; Provisional; Region: PRK10666 885275001506 acyl-CoA thioesterase II; Provisional; Region: PRK10526 885275001507 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 885275001508 active site 885275001509 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 885275001510 catalytic triad [active] 885275001511 dimer interface [polypeptide binding]; other site 885275001512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 885275001513 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 885275001514 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 885275001515 DNA binding site [nucleotide binding] 885275001516 active site 885275001517 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 885275001518 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 885275001519 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 885275001520 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885275001521 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 885275001522 maltose O-acetyltransferase; Provisional; Region: PRK10092 885275001523 Maltose acetyltransferase; Region: Mac; pfam12464 885275001524 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 885275001525 trimer interface [polypeptide binding]; other site 885275001526 active site 885275001527 substrate binding site [chemical binding]; other site 885275001528 CoA binding site [chemical binding]; other site 885275001529 gene expression modulator; Provisional; Region: PRK10945 885275001530 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 885275001531 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 885275001532 Protein export membrane protein; Region: SecD_SecF; cl14618 885275001533 Protein export membrane protein; Region: SecD_SecF; cl14618 885275001534 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 885275001535 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885275001536 HlyD family secretion protein; Region: HlyD_3; pfam13437 885275001537 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 885275001538 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 885275001539 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 885275001540 hypothetical protein; Provisional; Region: PRK11281 885275001541 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 885275001542 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 885275001543 Mechanosensitive ion channel; Region: MS_channel; pfam00924 885275001544 hypothetical protein; Provisional; Region: PRK11038 885275001545 primosomal replication protein N''; Provisional; Region: PRK10093 885275001546 hypothetical protein; Provisional; Region: PRK10527 885275001547 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 885275001548 active site 885275001549 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 885275001550 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275001551 Walker A motif; other site 885275001552 ATP binding site [chemical binding]; other site 885275001553 Walker B motif; other site 885275001554 DNA polymerase III subunit delta'; Validated; Region: PRK08485 885275001555 arginine finger; other site 885275001556 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 885275001557 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 885275001558 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 885275001559 hypothetical protein; Validated; Region: PRK00153 885275001560 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 885275001561 RecR protein; Region: RecR; pfam02132 885275001562 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 885275001563 putative active site [active] 885275001564 putative metal-binding site [ion binding]; other site 885275001565 tetramer interface [polypeptide binding]; other site 885275001566 heat shock protein 90; Provisional; Region: PRK05218 885275001567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275001568 ATP binding site [chemical binding]; other site 885275001569 Mg2+ binding site [ion binding]; other site 885275001570 G-X-G motif; other site 885275001571 adenylate kinase; Reviewed; Region: adk; PRK00279 885275001572 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 885275001573 AMP-binding site [chemical binding]; other site 885275001574 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 885275001575 ferrochelatase; Region: hemH; TIGR00109 885275001576 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 885275001577 C-terminal domain interface [polypeptide binding]; other site 885275001578 active site 885275001579 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 885275001580 active site 885275001581 N-terminal domain interface [polypeptide binding]; other site 885275001582 acetyl esterase; Provisional; Region: PRK10162 885275001583 inosine/guanosine kinase; Provisional; Region: PRK15074 885275001584 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 885275001585 putative cation:proton antiport protein; Provisional; Region: PRK10669 885275001586 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 885275001587 TrkA-N domain; Region: TrkA_N; pfam02254 885275001588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275001589 Major Facilitator Superfamily; Region: MFS_1; pfam07690 885275001590 putative substrate translocation pore; other site 885275001591 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 885275001592 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 885275001593 active site 885275001594 metal binding site [ion binding]; metal-binding site 885275001595 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 885275001596 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 885275001597 putative deacylase active site [active] 885275001598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 885275001599 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 885275001600 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 885275001601 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 885275001602 non-specific DNA binding site [nucleotide binding]; other site 885275001603 salt bridge; other site 885275001604 sequence-specific DNA binding site [nucleotide binding]; other site 885275001605 copper exporting ATPase; Provisional; Region: copA; PRK10671 885275001606 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 885275001607 metal-binding site [ion binding] 885275001608 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 885275001609 metal-binding site [ion binding] 885275001610 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 885275001611 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885275001612 motif II; other site 885275001613 glutaminase; Reviewed; Region: PRK12356 885275001614 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 885275001615 amino acid transporter; Region: 2A0306; TIGR00909 885275001616 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 885275001617 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 885275001618 DNA binding residues [nucleotide binding] 885275001619 dimer interface [polypeptide binding]; other site 885275001620 copper binding site [ion binding]; other site 885275001621 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 885275001622 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 885275001623 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 885275001624 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 885275001625 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885275001626 Walker A/P-loop; other site 885275001627 ATP binding site [chemical binding]; other site 885275001628 Q-loop/lid; other site 885275001629 ABC transporter signature motif; other site 885275001630 Walker B; other site 885275001631 D-loop; other site 885275001632 H-loop/switch region; other site 885275001633 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 885275001634 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 885275001635 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 885275001636 oxidoreductase; Provisional; Region: PRK08017 885275001637 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 885275001638 NADP binding site [chemical binding]; other site 885275001639 active site 885275001640 steroid binding site; other site 885275001641 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 885275001642 active site 885275001643 catalytic triad [active] 885275001644 oxyanion hole [active] 885275001645 switch loop; other site 885275001646 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 885275001647 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 885275001648 Walker A/P-loop; other site 885275001649 ATP binding site [chemical binding]; other site 885275001650 Q-loop/lid; other site 885275001651 ABC transporter signature motif; other site 885275001652 Walker B; other site 885275001653 D-loop; other site 885275001654 H-loop/switch region; other site 885275001655 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 885275001656 FtsX-like permease family; Region: FtsX; pfam02687 885275001657 FtsX-like permease family; Region: FtsX; pfam02687 885275001658 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 885275001659 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 885275001660 active site residue [active] 885275001661 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 885275001662 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275001663 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 885275001664 dimerization interface [polypeptide binding]; other site 885275001665 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 885275001666 ureidoglycolate hydrolase; Provisional; Region: PRK03606 885275001667 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 885275001668 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 885275001669 Bacterial transcriptional regulator; Region: IclR; pfam01614 885275001670 glyoxylate carboligase; Provisional; Region: PRK11269 885275001671 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 885275001672 PYR/PP interface [polypeptide binding]; other site 885275001673 dimer interface [polypeptide binding]; other site 885275001674 TPP binding site [chemical binding]; other site 885275001675 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 885275001676 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 885275001677 TPP-binding site [chemical binding]; other site 885275001678 hydroxypyruvate isomerase; Provisional; Region: PRK09997 885275001679 tartronate semialdehyde reductase; Provisional; Region: PRK15059 885275001680 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 885275001681 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 885275001682 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 885275001683 Na binding site [ion binding]; other site 885275001684 substrate binding site [chemical binding]; other site 885275001685 allantoinase; Provisional; Region: PRK08044 885275001686 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 885275001687 active site 885275001688 putative uracil/xanthine transporter; Provisional; Region: PRK11412 885275001689 glycerate kinase II; Provisional; Region: PRK09932 885275001690 putative allantoin catabolism protein; Region: ura-cupin; TIGR03214 885275001691 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 885275001692 Cupin domain; Region: Cupin_2; cl17218 885275001693 allantoate amidohydrolase; Region: AllC; TIGR03176 885275001694 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 885275001695 active site 885275001696 metal binding site [ion binding]; metal-binding site 885275001697 dimer interface [polypeptide binding]; other site 885275001698 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 885275001699 membrane protein FdrA; Validated; Region: PRK06091 885275001700 CoA binding domain; Region: CoA_binding; pfam02629 885275001701 CoA-ligase; Region: Ligase_CoA; pfam00549 885275001702 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 885275001703 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 885275001704 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 885275001705 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 885275001706 putative substrate binding site [chemical binding]; other site 885275001707 nucleotide binding site [chemical binding]; other site 885275001708 nucleotide binding site [chemical binding]; other site 885275001709 homodimer interface [polypeptide binding]; other site 885275001710 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 885275001711 ATP-grasp domain; Region: ATP-grasp; pfam02222 885275001712 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 885275001713 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 885275001714 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 885275001715 putative active site [active] 885275001716 putative metal binding site [ion binding]; other site 885275001717 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 885275001718 substrate binding site [chemical binding]; other site 885275001719 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 885275001720 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 885275001721 active site 885275001722 HIGH motif; other site 885275001723 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 885275001724 KMSKS motif; other site 885275001725 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 885275001726 tRNA binding surface [nucleotide binding]; other site 885275001727 anticodon binding site; other site 885275001728 ribosome-associated protein; Provisional; Region: PRK11507 885275001729 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 885275001730 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 885275001731 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 885275001732 homodimer interface [polypeptide binding]; other site 885275001733 NADP binding site [chemical binding]; other site 885275001734 substrate binding site [chemical binding]; other site 885275001735 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 885275001736 DNA binding site [nucleotide binding] 885275001737 active site 885275001738 Int/Topo IB signature motif; other site 885275001739 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 885275001740 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 885275001741 Methyltransferase domain; Region: Methyltransf_12; pfam08242 885275001742 S-adenosylmethionine binding site [chemical binding]; other site 885275001743 outer membrane protease; Reviewed; Region: PRK10993 885275001744 hypothetical protein; Provisional; Region: PRK09936 885275001745 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 885275001746 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 885275001747 TPR motif; other site 885275001748 binding surface 885275001749 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 885275001750 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 885275001751 active site 885275001752 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 885275001753 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 885275001754 sensor kinase CusS; Provisional; Region: PRK09835 885275001755 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 885275001756 dimerization interface [polypeptide binding]; other site 885275001757 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885275001758 dimer interface [polypeptide binding]; other site 885275001759 phosphorylation site [posttranslational modification] 885275001760 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275001761 ATP binding site [chemical binding]; other site 885275001762 Mg2+ binding site [ion binding]; other site 885275001763 G-X-G motif; other site 885275001764 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 885275001765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275001766 active site 885275001767 phosphorylation site [posttranslational modification] 885275001768 intermolecular recognition site; other site 885275001769 dimerization interface [polypeptide binding]; other site 885275001770 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 885275001771 DNA binding site [nucleotide binding] 885275001772 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 885275001773 periplasmic copper-binding protein; Provisional; Region: PRK09838 885275001774 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 885275001775 HlyD family secretion protein; Region: HlyD_3; pfam13437 885275001776 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 885275001777 phenylalanine transporter; Provisional; Region: PRK10249 885275001778 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 885275001779 Mechanosensitive ion channel; Region: MS_channel; pfam00924 885275001780 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 885275001781 dimer interface [polypeptide binding]; other site 885275001782 FMN binding site [chemical binding]; other site 885275001783 hypothetical protein; Provisional; Region: PRK10250 885275001784 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 885275001785 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 885275001786 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 885275001787 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 885275001788 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 885275001789 outer membrane receptor FepA; Provisional; Region: PRK13524 885275001790 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885275001791 N-terminal plug; other site 885275001792 ligand-binding site [chemical binding]; other site 885275001793 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 885275001794 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 885275001795 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 885275001796 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 885275001797 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 885275001798 acyl-activating enzyme (AAE) consensus motif; other site 885275001799 AMP binding site [chemical binding]; other site 885275001800 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885275001801 LPS O-antigen length regulator; Provisional; Region: PRK10381 885275001802 Chain length determinant protein; Region: Wzz; pfam02706 885275001803 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 885275001804 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 885275001805 Walker A/P-loop; other site 885275001806 ATP binding site [chemical binding]; other site 885275001807 Q-loop/lid; other site 885275001808 ABC transporter signature motif; other site 885275001809 Walker B; other site 885275001810 D-loop; other site 885275001811 H-loop/switch region; other site 885275001812 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 885275001813 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 885275001814 ABC-ATPase subunit interface; other site 885275001815 dimer interface [polypeptide binding]; other site 885275001816 putative PBP binding regions; other site 885275001817 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 885275001818 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 885275001819 ABC-ATPase subunit interface; other site 885275001820 dimer interface [polypeptide binding]; other site 885275001821 putative PBP binding regions; other site 885275001822 enterobactin exporter EntS; Provisional; Region: PRK10489 885275001823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275001824 putative substrate translocation pore; other site 885275001825 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 885275001826 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 885275001827 siderophore binding site; other site 885275001828 isochorismate synthase EntC; Provisional; Region: PRK15016 885275001829 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 885275001830 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 885275001831 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 885275001832 acyl-activating enzyme (AAE) consensus motif; other site 885275001833 active site 885275001834 AMP binding site [chemical binding]; other site 885275001835 substrate binding site [chemical binding]; other site 885275001836 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 885275001837 hydrophobic substrate binding pocket; other site 885275001838 Isochorismatase family; Region: Isochorismatase; pfam00857 885275001839 active site 885275001840 conserved cis-peptide bond; other site 885275001841 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 885275001842 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 885275001843 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 885275001844 putative NAD(P) binding site [chemical binding]; other site 885275001845 active site 885275001846 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 885275001847 CoenzymeA binding site [chemical binding]; other site 885275001848 subunit interaction site [polypeptide binding]; other site 885275001849 PHB binding site; other site 885275001850 carbon starvation protein A; Provisional; Region: PRK15015 885275001851 Carbon starvation protein CstA; Region: CstA; pfam02554 885275001852 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 885275001853 Uncharacterized small protein [Function unknown]; Region: COG2879 885275001854 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 885275001855 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 885275001856 putative active site [active] 885275001857 metal binding site [ion binding]; metal-binding site 885275001858 methionine aminotransferase; Validated; Region: PRK09082 885275001859 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 885275001860 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275001861 homodimer interface [polypeptide binding]; other site 885275001862 catalytic residue [active] 885275001863 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 885275001864 ParB-like nuclease domain; Region: ParBc; pfam02195 885275001865 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 885275001866 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 885275001867 Active Sites [active] 885275001868 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 885275001869 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 885275001870 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275001871 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 885275001872 dimerization interface [polypeptide binding]; other site 885275001873 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 885275001874 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 885275001875 dimerization domain [polypeptide binding]; other site 885275001876 dimer interface [polypeptide binding]; other site 885275001877 catalytic residues [active] 885275001878 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 885275001879 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 885275001880 dimer interface [polypeptide binding]; other site 885275001881 decamer (pentamer of dimers) interface [polypeptide binding]; other site 885275001882 catalytic triad [active] 885275001883 peroxidatic and resolving cysteines [active] 885275001884 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 885275001885 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 885275001886 catalytic residue [active] 885275001887 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 885275001888 catalytic residues [active] 885275001889 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 885275001890 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 885275001891 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 885275001892 Ligand Binding Site [chemical binding]; other site 885275001893 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 885275001894 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 885275001895 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 885275001896 B1 nucleotide binding pocket [chemical binding]; other site 885275001897 B2 nucleotide binding pocket [chemical binding]; other site 885275001898 CAS motifs; other site 885275001899 active site 885275001900 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 885275001901 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 885275001902 transmembrane helices; other site 885275001903 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 885275001904 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 885275001905 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 885275001906 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 885275001907 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 885275001908 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 885275001909 putative active site [active] 885275001910 (T/H)XGH motif; other site 885275001911 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 885275001912 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 885275001913 putative active site [active] 885275001914 heme pocket [chemical binding]; other site 885275001915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275001916 ATP binding site [chemical binding]; other site 885275001917 Mg2+ binding site [ion binding]; other site 885275001918 G-X-G motif; other site 885275001919 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 885275001920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275001921 active site 885275001922 phosphorylation site [posttranslational modification] 885275001923 intermolecular recognition site; other site 885275001924 dimerization interface [polypeptide binding]; other site 885275001925 Transcriptional regulator; Region: CitT; pfam12431 885275001926 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 885275001927 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 885275001928 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 885275001929 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 885275001930 DNA-binding site [nucleotide binding]; DNA binding site 885275001931 RNA-binding motif; other site 885275001932 chromosome condensation membrane protein; Provisional; Region: PRK14196 885275001933 Predicted amidohydrolase [General function prediction only]; Region: COG0388 885275001934 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 885275001935 putative active site [active] 885275001936 catalytic triad [active] 885275001937 putative dimer interface [polypeptide binding]; other site 885275001938 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 885275001939 lipoyl synthase; Provisional; Region: PRK05481 885275001940 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885275001941 FeS/SAM binding site; other site 885275001942 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 885275001943 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 885275001944 lipoate-protein ligase B; Provisional; Region: PRK14342 885275001945 hypothetical protein; Provisional; Region: PRK04998 885275001946 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 885275001947 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 885275001948 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 885275001949 rare lipoprotein A; Provisional; Region: PRK10672 885275001950 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 885275001951 Sporulation related domain; Region: SPOR; pfam05036 885275001952 cell wall shape-determining protein; Provisional; Region: PRK10794 885275001953 penicillin-binding protein 2; Provisional; Region: PRK10795 885275001954 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 885275001955 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 885275001956 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 885275001957 ribosome-associated protein; Provisional; Region: PRK11538 885275001958 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 885275001959 catalytic core [active] 885275001960 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 885275001961 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 885275001962 active site 885275001963 (T/H)XGH motif; other site 885275001964 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 885275001965 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 885275001966 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 885275001967 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 885275001968 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 885275001969 HIGH motif; other site 885275001970 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 885275001971 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 885275001972 active site 885275001973 KMSKS motif; other site 885275001974 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 885275001975 tRNA binding surface [nucleotide binding]; other site 885275001976 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 885275001977 hypothetical protein; Provisional; Region: PRK11032 885275001978 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 885275001979 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 885275001980 active site 885275001981 tetramer interface [polypeptide binding]; other site 885275001982 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 885275001983 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 885275001984 Walker A/P-loop; other site 885275001985 ATP binding site [chemical binding]; other site 885275001986 Q-loop/lid; other site 885275001987 ABC transporter signature motif; other site 885275001988 Walker B; other site 885275001989 D-loop; other site 885275001990 H-loop/switch region; other site 885275001991 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 885275001992 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275001993 dimer interface [polypeptide binding]; other site 885275001994 conserved gate region; other site 885275001995 putative PBP binding loops; other site 885275001996 ABC-ATPase subunit interface; other site 885275001997 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 885275001998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275001999 dimer interface [polypeptide binding]; other site 885275002000 conserved gate region; other site 885275002001 putative PBP binding loops; other site 885275002002 ABC-ATPase subunit interface; other site 885275002003 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 885275002004 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 885275002005 substrate binding pocket [chemical binding]; other site 885275002006 membrane-bound complex binding site; other site 885275002007 hinge residues; other site 885275002008 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 885275002009 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 885275002010 Uncharacterized conserved protein [Function unknown]; Region: COG3391 885275002011 structural tetrad; other site 885275002012 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 885275002013 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 885275002014 putative active site [active] 885275002015 catalytic triad [active] 885275002016 putative dimer interface [polypeptide binding]; other site 885275002017 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 885275002018 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 885275002019 Transporter associated domain; Region: CorC_HlyC; smart01091 885275002020 metal-binding heat shock protein; Provisional; Region: PRK00016 885275002021 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 885275002022 PhoH-like protein; Region: PhoH; pfam02562 885275002023 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 885275002024 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 885275002025 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885275002026 FeS/SAM binding site; other site 885275002027 TRAM domain; Region: TRAM; pfam01938 885275002028 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 885275002029 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 885275002030 asparagine synthetase B; Provisional; Region: asnB; PRK09431 885275002031 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 885275002032 active site 885275002033 dimer interface [polypeptide binding]; other site 885275002034 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 885275002035 Ligand Binding Site [chemical binding]; other site 885275002036 Molecular Tunnel; other site 885275002037 UMP phosphatase; Provisional; Region: PRK10444 885275002038 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885275002039 active site 885275002040 motif I; other site 885275002041 motif II; other site 885275002042 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885275002043 MarR family; Region: MarR; pfam01047 885275002044 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 885275002045 ROK family; Region: ROK; pfam00480 885275002046 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 885275002047 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 885275002048 active site 885275002049 dimer interface [polypeptide binding]; other site 885275002050 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 885275002051 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 885275002052 active site 885275002053 trimer interface [polypeptide binding]; other site 885275002054 allosteric site; other site 885275002055 active site lid [active] 885275002056 hexamer (dimer of trimers) interface [polypeptide binding]; other site 885275002057 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 885275002058 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 885275002059 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 885275002060 active site turn [active] 885275002061 phosphorylation site [posttranslational modification] 885275002062 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 885275002063 HPr interaction site; other site 885275002064 glycerol kinase (GK) interaction site [polypeptide binding]; other site 885275002065 active site 885275002066 phosphorylation site [posttranslational modification] 885275002067 bifunctional phosphoglucose/phosphomannose isomerase; Region: G6PI_arch; TIGR02128 885275002068 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 885275002069 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 885275002070 transmembrane helices; other site 885275002071 Domain of unknown function (DUF386); Region: DUF386; cl01047 885275002072 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 885275002073 BNR repeat-like domain; Region: BNR_2; pfam13088 885275002074 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 885275002075 dihydrodipicolinate synthase; Region: dapA; TIGR00674 885275002076 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 885275002077 inhibitor site; inhibition site 885275002078 active site 885275002079 dimer interface [polypeptide binding]; other site 885275002080 catalytic residue [active] 885275002081 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 885275002082 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 885275002083 putative active site [active] 885275002084 metal binding site [ion binding]; metal-binding site 885275002085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 885275002086 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 885275002087 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 885275002088 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 885275002089 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 885275002090 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 885275002091 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 885275002092 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 885275002093 active site 885275002094 HIGH motif; other site 885275002095 nucleotide binding site [chemical binding]; other site 885275002096 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 885275002097 KMSKS motif; other site 885275002098 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 885275002099 outer membrane porin, OprD family; Region: OprD; pfam03573 885275002100 YbfN-like lipoprotein; Region: YbfN; pfam13982 885275002101 ferric uptake regulator; Provisional; Region: fur; PRK09462 885275002102 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 885275002103 metal binding site 2 [ion binding]; metal-binding site 885275002104 putative DNA binding helix; other site 885275002105 metal binding site 1 [ion binding]; metal-binding site 885275002106 dimer interface [polypeptide binding]; other site 885275002107 structural Zn2+ binding site [ion binding]; other site 885275002108 flavodoxin FldA; Validated; Region: PRK09267 885275002109 LexA regulated protein; Provisional; Region: PRK11675 885275002110 acyl-CoA esterase; Provisional; Region: PRK10673 885275002111 PGAP1-like protein; Region: PGAP1; pfam07819 885275002112 replication initiation regulator SeqA; Provisional; Region: PRK11187 885275002113 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 885275002114 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 885275002115 active site 885275002116 substrate binding site [chemical binding]; other site 885275002117 metal binding site [ion binding]; metal-binding site 885275002118 putrescine transporter; Provisional; Region: potE; PRK10655 885275002119 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 885275002120 ornithine decarboxylase; Provisional; Region: PRK13578 885275002121 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 885275002122 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 885275002123 homodimer interface [polypeptide binding]; other site 885275002124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275002125 catalytic residue [active] 885275002126 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 885275002127 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 885275002128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275002129 active site 885275002130 phosphorylation site [posttranslational modification] 885275002131 intermolecular recognition site; other site 885275002132 dimerization interface [polypeptide binding]; other site 885275002133 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 885275002134 DNA binding site [nucleotide binding] 885275002135 sensor protein KdpD; Provisional; Region: PRK10490 885275002136 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 885275002137 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 885275002138 Ligand Binding Site [chemical binding]; other site 885275002139 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 885275002140 GAF domain; Region: GAF_3; pfam13492 885275002141 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885275002142 dimer interface [polypeptide binding]; other site 885275002143 phosphorylation site [posttranslational modification] 885275002144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275002145 ATP binding site [chemical binding]; other site 885275002146 Mg2+ binding site [ion binding]; other site 885275002147 G-X-G motif; other site 885275002148 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 885275002149 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 885275002150 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 885275002151 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 885275002152 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 885275002153 hypothetical protein; Provisional; Region: PRK10167 885275002154 Uncharacterized conserved protein [Function unknown]; Region: COG3272 885275002155 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 885275002156 DNA photolyase; Region: DNA_photolyase; pfam00875 885275002157 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 885275002158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275002159 putative substrate translocation pore; other site 885275002160 POT family; Region: PTR2; pfam00854 885275002161 Uncharacterized conserved protein [Function unknown]; Region: COG0327 885275002162 metal-binding protein; Provisional; Region: PRK10799 885275002163 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 885275002164 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 885275002165 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 885275002166 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 885275002167 putative active site [active] 885275002168 endonuclease VIII; Provisional; Region: PRK10445 885275002169 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 885275002170 DNA binding site [nucleotide binding] 885275002171 catalytic residue [active] 885275002172 putative catalytic residues [active] 885275002173 H2TH interface [polypeptide binding]; other site 885275002174 intercalation triad [nucleotide binding]; other site 885275002175 substrate specificity determining residue; other site 885275002176 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 885275002177 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 885275002178 Putative ammonia monooxygenase; Region: AmoA; pfam05145 885275002179 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 885275002180 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 885275002181 Fimbrial protein; Region: Fimbrial; cl01416 885275002182 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 885275002183 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 885275002184 dimer interface [polypeptide binding]; other site 885275002185 active site 885275002186 citrylCoA binding site [chemical binding]; other site 885275002187 NADH binding [chemical binding]; other site 885275002188 cationic pore residues; other site 885275002189 oxalacetate/citrate binding site [chemical binding]; other site 885275002190 coenzyme A binding site [chemical binding]; other site 885275002191 catalytic triad [active] 885275002192 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 885275002193 Iron-sulfur protein interface; other site 885275002194 proximal quinone binding site [chemical binding]; other site 885275002195 SdhD (CybS) interface [polypeptide binding]; other site 885275002196 proximal heme binding site [chemical binding]; other site 885275002197 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 885275002198 SdhC subunit interface [polypeptide binding]; other site 885275002199 proximal heme binding site [chemical binding]; other site 885275002200 cardiolipin binding site; other site 885275002201 Iron-sulfur protein interface; other site 885275002202 proximal quinone binding site [chemical binding]; other site 885275002203 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 885275002204 L-aspartate oxidase; Provisional; Region: PRK06175 885275002205 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 885275002206 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 885275002207 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 885275002208 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 885275002209 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 885275002210 TPP-binding site [chemical binding]; other site 885275002211 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 885275002212 dimer interface [polypeptide binding]; other site 885275002213 PYR/PP interface [polypeptide binding]; other site 885275002214 TPP binding site [chemical binding]; other site 885275002215 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 885275002216 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 885275002217 E3 interaction surface; other site 885275002218 lipoyl attachment site [posttranslational modification]; other site 885275002219 e3 binding domain; Region: E3_binding; pfam02817 885275002220 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 885275002221 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 885275002222 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 885275002223 CoA-ligase; Region: Ligase_CoA; pfam00549 885275002224 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 885275002225 CoA binding domain; Region: CoA_binding; smart00881 885275002226 CoA-ligase; Region: Ligase_CoA; pfam00549 885275002227 TPR repeat; Region: TPR_11; pfam13414 885275002228 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 885275002229 binding surface 885275002230 TPR motif; other site 885275002231 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 885275002232 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 885275002233 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 885275002234 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 885275002235 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 885275002236 hypothetical protein; Provisional; Region: PRK10588 885275002237 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 885275002238 active site 885275002239 colicin uptake protein TolQ; Provisional; Region: PRK10801 885275002240 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 885275002241 colicin uptake protein TolR; Provisional; Region: PRK11024 885275002242 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 885275002243 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 885275002244 TolA C-terminal; Region: TolA; pfam06519 885275002245 translocation protein TolB; Provisional; Region: tolB; PRK03629 885275002246 TolB amino-terminal domain; Region: TolB_N; pfam04052 885275002247 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 885275002248 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 885275002249 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 885275002250 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 885275002251 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 885275002252 ligand binding site [chemical binding]; other site 885275002253 tol-pal system protein YbgF; Provisional; Region: PRK10803 885275002254 Tetratricopeptide repeat; Region: TPR_6; pfam13174 885275002255 Tetratricopeptide repeat; Region: TPR_6; pfam13174 885275002256 quinolinate synthetase; Provisional; Region: PRK09375 885275002257 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 885275002258 Cation efflux family; Region: Cation_efflux; cl00316 885275002259 YbgS-like protein; Region: YbgS; pfam13985 885275002260 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 885275002261 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 885275002262 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 885275002263 catalytic core [active] 885275002264 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 885275002265 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 885275002266 active site 885275002267 catalytic residues [active] 885275002268 galactokinase; Provisional; Region: PRK05101 885275002269 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 885275002270 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 885275002271 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 885275002272 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 885275002273 dimer interface [polypeptide binding]; other site 885275002274 active site 885275002275 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 885275002276 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 885275002277 NAD binding site [chemical binding]; other site 885275002278 homodimer interface [polypeptide binding]; other site 885275002279 active site 885275002280 substrate binding site [chemical binding]; other site 885275002281 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 885275002282 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 885275002283 Walker A/P-loop; other site 885275002284 ATP binding site [chemical binding]; other site 885275002285 Q-loop/lid; other site 885275002286 ABC transporter signature motif; other site 885275002287 Walker B; other site 885275002288 D-loop; other site 885275002289 H-loop/switch region; other site 885275002290 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885275002291 Walker A/P-loop; other site 885275002292 ATP binding site [chemical binding]; other site 885275002293 Q-loop/lid; other site 885275002294 ABC transporter signature motif; other site 885275002295 Walker B; other site 885275002296 D-loop; other site 885275002297 H-loop/switch region; other site 885275002298 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 885275002299 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 885275002300 molybdenum-pterin binding domain; Region: Mop; TIGR00638 885275002301 TOBE domain; Region: TOBE; pfam03459 885275002302 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 885275002303 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 885275002304 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 885275002305 substrate binding pocket [chemical binding]; other site 885275002306 membrane-bound complex binding site; other site 885275002307 hinge residues; other site 885275002308 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 885275002309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275002310 dimer interface [polypeptide binding]; other site 885275002311 conserved gate region; other site 885275002312 putative PBP binding loops; other site 885275002313 ABC-ATPase subunit interface; other site 885275002314 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 885275002315 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885275002316 Walker A/P-loop; other site 885275002317 ATP binding site [chemical binding]; other site 885275002318 Q-loop/lid; other site 885275002319 ABC transporter signature motif; other site 885275002320 Walker B; other site 885275002321 D-loop; other site 885275002322 H-loop/switch region; other site 885275002323 molybdenum-pterin binding domain; Region: Mop; TIGR00638 885275002324 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 885275002325 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885275002326 motif II; other site 885275002327 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885275002328 6-phosphogluconolactonase; Provisional; Region: PRK11028 885275002329 Transcriptional regulator [Transcription]; Region: LysR; COG0583 885275002330 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275002331 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 885275002332 putative dimerization interface [polypeptide binding]; other site 885275002333 PrpF protein; Region: PrpF; pfam04303 885275002334 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 885275002335 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 885275002336 transmembrane helices; other site 885275002337 putative hydratase; Provisional; Region: PRK11413 885275002338 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 885275002339 substrate binding site [chemical binding]; other site 885275002340 ligand binding site [chemical binding]; other site 885275002341 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 885275002342 substrate binding site [chemical binding]; other site 885275002343 acyl-CoA thioesterase; Provisional; Region: PRK10531 885275002344 putative pectinesterase; Region: PLN02432; cl01911 885275002345 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 885275002346 substrate binding site [chemical binding]; other site 885275002347 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 885275002348 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 885275002349 Probable transposase; Region: OrfB_IS605; pfam01385 885275002350 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 885275002351 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 885275002352 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 885275002353 inhibitor-cofactor binding pocket; inhibition site 885275002354 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275002355 catalytic residue [active] 885275002356 biotin synthase; Provisional; Region: PRK15108 885275002357 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885275002358 FeS/SAM binding site; other site 885275002359 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 885275002360 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 885275002361 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 885275002362 substrate-cofactor binding pocket; other site 885275002363 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275002364 catalytic residue [active] 885275002365 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 885275002366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275002367 S-adenosylmethionine binding site [chemical binding]; other site 885275002368 AAA domain; Region: AAA_26; pfam13500 885275002369 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 885275002370 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 885275002371 ADP binding site [chemical binding]; other site 885275002372 excinuclease ABC subunit B; Provisional; Region: PRK05298 885275002373 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 885275002374 ATP binding site [chemical binding]; other site 885275002375 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 885275002376 nucleotide binding region [chemical binding]; other site 885275002377 ATP-binding site [chemical binding]; other site 885275002378 Ultra-violet resistance protein B; Region: UvrB; pfam12344 885275002379 UvrB/uvrC motif; Region: UVR; pfam02151 885275002380 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 885275002381 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 885275002382 putative substrate binding pocket [chemical binding]; other site 885275002383 dimer interface [polypeptide binding]; other site 885275002384 phosphate binding site [ion binding]; other site 885275002385 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 885275002386 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885275002387 FeS/SAM binding site; other site 885275002388 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 885275002389 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 885275002390 MPT binding site; other site 885275002391 trimer interface [polypeptide binding]; other site 885275002392 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 885275002393 trimer interface [polypeptide binding]; other site 885275002394 dimer interface [polypeptide binding]; other site 885275002395 putative active site [active] 885275002396 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 885275002397 MoaE interaction surface [polypeptide binding]; other site 885275002398 MoeB interaction surface [polypeptide binding]; other site 885275002399 thiocarboxylated glycine; other site 885275002400 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 885275002401 MoaE homodimer interface [polypeptide binding]; other site 885275002402 MoaD interaction [polypeptide binding]; other site 885275002403 active site residues [active] 885275002404 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 885275002405 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 885275002406 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 885275002407 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 885275002408 Predicted integral membrane protein [Function unknown]; Region: COG0392 885275002409 cardiolipin synthase 2; Provisional; Region: PRK11263 885275002410 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 885275002411 putative active site [active] 885275002412 catalytic site [active] 885275002413 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 885275002414 putative active site [active] 885275002415 catalytic site [active] 885275002416 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 885275002417 putative catalytic site [active] 885275002418 putative metal binding site [ion binding]; other site 885275002419 putative phosphate binding site [ion binding]; other site 885275002420 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 885275002421 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 885275002422 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 885275002423 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 885275002424 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 885275002425 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 885275002426 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 885275002427 Walker A/P-loop; other site 885275002428 ATP binding site [chemical binding]; other site 885275002429 Q-loop/lid; other site 885275002430 ABC transporter signature motif; other site 885275002431 Walker B; other site 885275002432 D-loop; other site 885275002433 H-loop/switch region; other site 885275002434 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 885275002435 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 885275002436 Walker A/P-loop; other site 885275002437 ATP binding site [chemical binding]; other site 885275002438 Q-loop/lid; other site 885275002439 ABC transporter signature motif; other site 885275002440 Walker B; other site 885275002441 D-loop; other site 885275002442 H-loop/switch region; other site 885275002443 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 885275002444 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885275002445 HlyD family secretion protein; Region: HlyD_3; pfam13437 885275002446 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 885275002447 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 885275002448 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 885275002449 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 885275002450 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 885275002451 ATP binding site [chemical binding]; other site 885275002452 Mg++ binding site [ion binding]; other site 885275002453 motif III; other site 885275002454 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 885275002455 nucleotide binding region [chemical binding]; other site 885275002456 ATP-binding site [chemical binding]; other site 885275002457 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 885275002458 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 885275002459 DEAD_2; Region: DEAD_2; pfam06733 885275002460 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 885275002461 glycosyl transferase family protein; Provisional; Region: PRK08136 885275002462 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 885275002463 putative dehydrogenase; Provisional; Region: PRK10098 885275002464 hypothetical protein; Provisional; Region: PRK10259 885275002465 hypothetical protein; Provisional; Region: PRK11019 885275002466 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 885275002467 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 885275002468 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885275002469 N-terminal plug; other site 885275002470 ligand-binding site [chemical binding]; other site 885275002471 hypothetical protein; Provisional; Region: PRK10259 885275002472 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 885275002473 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 885275002474 putative mechanosensitive channel protein; Provisional; Region: PRK11465 885275002475 Mechanosensitive ion channel; Region: MS_channel; pfam00924 885275002476 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 885275002477 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 885275002478 Walker A/P-loop; other site 885275002479 ATP binding site [chemical binding]; other site 885275002480 Q-loop/lid; other site 885275002481 ABC transporter signature motif; other site 885275002482 Walker B; other site 885275002483 D-loop; other site 885275002484 H-loop/switch region; other site 885275002485 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 885275002486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275002487 dimer interface [polypeptide binding]; other site 885275002488 conserved gate region; other site 885275002489 putative PBP binding loops; other site 885275002490 ABC-ATPase subunit interface; other site 885275002491 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 885275002492 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 885275002493 substrate binding pocket [chemical binding]; other site 885275002494 membrane-bound complex binding site; other site 885275002495 hinge residues; other site 885275002496 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 885275002497 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 885275002498 dimerization interface [polypeptide binding]; other site 885275002499 DPS ferroxidase diiron center [ion binding]; other site 885275002500 ion pore; other site 885275002501 threonine and homoserine efflux system; Provisional; Region: PRK10532 885275002502 EamA-like transporter family; Region: EamA; pfam00892 885275002503 outer membrane protein X; Provisional; Region: ompX; PRK09408 885275002504 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 885275002505 Sulfatase; Region: Sulfatase; pfam00884 885275002506 manganese transport regulator MntR; Provisional; Region: PRK11050 885275002507 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 885275002508 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 885275002509 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 885275002510 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 885275002511 transmembrane helices; other site 885275002512 L,D-transpeptidase; Provisional; Region: PRK10260 885275002513 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 885275002514 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 885275002515 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885275002516 Walker A/P-loop; other site 885275002517 ATP binding site [chemical binding]; other site 885275002518 Q-loop/lid; other site 885275002519 ABC transporter signature motif; other site 885275002520 Walker B; other site 885275002521 D-loop; other site 885275002522 H-loop/switch region; other site 885275002523 ABC transporter; Region: ABC_tran_2; pfam12848 885275002524 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 885275002525 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 885275002526 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885275002527 active site 885275002528 motif I; other site 885275002529 motif II; other site 885275002530 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885275002531 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 885275002532 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 885275002533 dimer interface [polypeptide binding]; other site 885275002534 active site 885275002535 glycine loop; other site 885275002536 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 885275002537 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 885275002538 active site 885275002539 intersubunit interactions; other site 885275002540 catalytic residue [active] 885275002541 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 885275002542 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 885275002543 ATP binding site [chemical binding]; other site 885275002544 substrate interface [chemical binding]; other site 885275002545 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 885275002546 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 885275002547 dimer interface [polypeptide binding]; other site 885275002548 putative functional site; other site 885275002549 putative MPT binding site; other site 885275002550 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 885275002551 catalytic nucleophile [active] 885275002552 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 885275002553 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 885275002554 Walker A/P-loop; other site 885275002555 ATP binding site [chemical binding]; other site 885275002556 Q-loop/lid; other site 885275002557 ABC transporter signature motif; other site 885275002558 Walker B; other site 885275002559 D-loop; other site 885275002560 H-loop/switch region; other site 885275002561 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 885275002562 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 885275002563 Walker A/P-loop; other site 885275002564 ATP binding site [chemical binding]; other site 885275002565 Q-loop/lid; other site 885275002566 ABC transporter signature motif; other site 885275002567 Walker B; other site 885275002568 D-loop; other site 885275002569 H-loop/switch region; other site 885275002570 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 885275002571 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 885275002572 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 885275002573 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 885275002574 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275002575 dimer interface [polypeptide binding]; other site 885275002576 conserved gate region; other site 885275002577 putative PBP binding loops; other site 885275002578 ABC-ATPase subunit interface; other site 885275002579 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 885275002580 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 885275002581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275002582 dimer interface [polypeptide binding]; other site 885275002583 conserved gate region; other site 885275002584 putative PBP binding loops; other site 885275002585 ABC-ATPase subunit interface; other site 885275002586 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885275002587 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 885275002588 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885275002589 metal binding site [ion binding]; metal-binding site 885275002590 active site 885275002591 I-site; other site 885275002592 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 885275002593 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 885275002594 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885275002595 FeS/SAM binding site; other site 885275002596 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 885275002597 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 885275002598 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 885275002599 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 885275002600 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 885275002601 putative C-terminal domain interface [polypeptide binding]; other site 885275002602 putative GSH binding site (G-site) [chemical binding]; other site 885275002603 putative dimer interface [polypeptide binding]; other site 885275002604 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 885275002605 N-terminal domain interface [polypeptide binding]; other site 885275002606 dimer interface [polypeptide binding]; other site 885275002607 substrate binding pocket (H-site) [chemical binding]; other site 885275002608 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 885275002609 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 885275002610 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 885275002611 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 885275002612 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 885275002613 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 885275002614 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 885275002615 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 885275002616 active site 885275002617 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 885275002618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275002619 putative substrate translocation pore; other site 885275002620 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 885275002621 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885275002622 active site 885275002623 motif I; other site 885275002624 motif II; other site 885275002625 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885275002626 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 885275002627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275002628 putative substrate translocation pore; other site 885275002629 Major Facilitator Superfamily; Region: MFS_1; pfam07690 885275002630 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 885275002631 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 885275002632 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 885275002633 putative transporter; Provisional; Region: PRK04972 885275002634 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 885275002635 TrkA-C domain; Region: TrkA_C; pfam02080 885275002636 TrkA-C domain; Region: TrkA_C; pfam02080 885275002637 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 885275002638 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 885275002639 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 885275002640 GSH binding site [chemical binding]; other site 885275002641 catalytic residues [active] 885275002642 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 885275002643 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 885275002644 dimer interface [polypeptide binding]; other site 885275002645 FMN binding site [chemical binding]; other site 885275002646 NADPH bind site [chemical binding]; other site 885275002647 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 885275002648 RimK-like ATP-grasp domain; Region: RimK; pfam08443 885275002649 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 885275002650 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 885275002651 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 885275002652 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 885275002653 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885275002654 Walker A/P-loop; other site 885275002655 ATP binding site [chemical binding]; other site 885275002656 Q-loop/lid; other site 885275002657 ABC transporter signature motif; other site 885275002658 Walker B; other site 885275002659 D-loop; other site 885275002660 H-loop/switch region; other site 885275002661 TOBE domain; Region: TOBE_2; pfam08402 885275002662 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 885275002663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275002664 dimer interface [polypeptide binding]; other site 885275002665 conserved gate region; other site 885275002666 putative PBP binding loops; other site 885275002667 ABC-ATPase subunit interface; other site 885275002668 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 885275002669 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 885275002670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275002671 S-adenosylmethionine binding site [chemical binding]; other site 885275002672 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 885275002673 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 885275002674 substrate binding pocket [chemical binding]; other site 885275002675 membrane-bound complex binding site; other site 885275002676 hinge residues; other site 885275002677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275002678 dimer interface [polypeptide binding]; other site 885275002679 conserved gate region; other site 885275002680 putative PBP binding loops; other site 885275002681 ABC-ATPase subunit interface; other site 885275002682 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 885275002683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275002684 dimer interface [polypeptide binding]; other site 885275002685 conserved gate region; other site 885275002686 putative PBP binding loops; other site 885275002687 ABC-ATPase subunit interface; other site 885275002688 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 885275002689 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 885275002690 substrate binding pocket [chemical binding]; other site 885275002691 membrane-bound complex binding site; other site 885275002692 hinge residues; other site 885275002693 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 885275002694 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885275002695 Walker A/P-loop; other site 885275002696 ATP binding site [chemical binding]; other site 885275002697 Q-loop/lid; other site 885275002698 ABC transporter signature motif; other site 885275002699 Walker B; other site 885275002700 D-loop; other site 885275002701 H-loop/switch region; other site 885275002702 putative lipoprotein; Provisional; Region: PRK10533 885275002703 hypothetical protein; Provisional; Region: PRK02877 885275002704 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 885275002705 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 885275002706 amidase catalytic site [active] 885275002707 Zn binding residues [ion binding]; other site 885275002708 substrate binding site [chemical binding]; other site 885275002709 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 885275002710 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 885275002711 NAD(P) binding site [chemical binding]; other site 885275002712 active site 885275002713 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 885275002714 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 885275002715 putative NAD(P) binding site [chemical binding]; other site 885275002716 putative active site [active] 885275002717 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 885275002718 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 885275002719 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 885275002720 tetramer interface [polypeptide binding]; other site 885275002721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275002722 catalytic residue [active] 885275002723 pyruvate dehydrogenase; Provisional; Region: PRK09124 885275002724 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 885275002725 PYR/PP interface [polypeptide binding]; other site 885275002726 dimer interface [polypeptide binding]; other site 885275002727 tetramer interface [polypeptide binding]; other site 885275002728 TPP binding site [chemical binding]; other site 885275002729 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 885275002730 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 885275002731 TPP-binding site [chemical binding]; other site 885275002732 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 885275002733 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 885275002734 FAD binding pocket [chemical binding]; other site 885275002735 FAD binding motif [chemical binding]; other site 885275002736 phosphate binding motif [ion binding]; other site 885275002737 beta-alpha-beta structure motif; other site 885275002738 NAD binding pocket [chemical binding]; other site 885275002739 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 885275002740 catalytic loop [active] 885275002741 iron binding site [ion binding]; other site 885275002742 hybrid cluster protein; Provisional; Region: PRK05290 885275002743 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 885275002744 ACS interaction site; other site 885275002745 CODH interaction site; other site 885275002746 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 885275002747 hybrid metal cluster; other site 885275002748 Predicted membrane protein [Function unknown]; Region: COG2431 885275002749 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 885275002750 amphipathic channel; other site 885275002751 Asn-Pro-Ala signature motifs; other site 885275002752 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 885275002753 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 885275002754 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 885275002755 putative active site [active] 885275002756 putative metal-binding site [ion binding]; other site 885275002757 Protein of unknown function (DUF535); Region: DUF535; pfam04393 885275002758 macrolide transporter subunit MacA; Provisional; Region: PRK11578 885275002759 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885275002760 HlyD family secretion protein; Region: HlyD_3; pfam13437 885275002761 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 885275002762 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 885275002763 Walker A/P-loop; other site 885275002764 ATP binding site [chemical binding]; other site 885275002765 Q-loop/lid; other site 885275002766 ABC transporter signature motif; other site 885275002767 Walker B; other site 885275002768 D-loop; other site 885275002769 H-loop/switch region; other site 885275002770 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 885275002771 FtsX-like permease family; Region: FtsX; pfam02687 885275002772 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 885275002773 DNA-binding site [nucleotide binding]; DNA binding site 885275002774 RNA-binding motif; other site 885275002775 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 885275002776 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 885275002777 Clp amino terminal domain; Region: Clp_N; pfam02861 885275002778 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275002779 Walker A motif; other site 885275002780 ATP binding site [chemical binding]; other site 885275002781 Walker B motif; other site 885275002782 arginine finger; other site 885275002783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275002784 Walker A motif; other site 885275002785 ATP binding site [chemical binding]; other site 885275002786 Walker B motif; other site 885275002787 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 885275002788 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 885275002789 rRNA binding site [nucleotide binding]; other site 885275002790 predicted 30S ribosome binding site; other site 885275002791 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 885275002792 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 885275002793 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 885275002794 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 885275002795 Walker A/P-loop; other site 885275002796 ATP binding site [chemical binding]; other site 885275002797 Q-loop/lid; other site 885275002798 ABC transporter signature motif; other site 885275002799 Walker B; other site 885275002800 D-loop; other site 885275002801 H-loop/switch region; other site 885275002802 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 885275002803 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 885275002804 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885275002805 Walker A/P-loop; other site 885275002806 ATP binding site [chemical binding]; other site 885275002807 Q-loop/lid; other site 885275002808 ABC transporter signature motif; other site 885275002809 Walker B; other site 885275002810 D-loop; other site 885275002811 H-loop/switch region; other site 885275002812 thioredoxin reductase; Provisional; Region: PRK10262 885275002813 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 885275002814 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 885275002815 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 885275002816 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 885275002817 putative DNA binding site [nucleotide binding]; other site 885275002818 putative Zn2+ binding site [ion binding]; other site 885275002819 AsnC family; Region: AsnC_trans_reg; pfam01037 885275002820 DNA translocase FtsK; Provisional; Region: PRK10263 885275002821 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 885275002822 DNA translocase FtsK; Provisional; Region: PRK10263 885275002823 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 885275002824 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 885275002825 periplasmic chaperone LolA; Region: lolA; TIGR00547 885275002826 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 885275002827 recombination factor protein RarA; Reviewed; Region: PRK13342 885275002828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275002829 Walker A motif; other site 885275002830 ATP binding site [chemical binding]; other site 885275002831 Walker B motif; other site 885275002832 arginine finger; other site 885275002833 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 885275002834 seryl-tRNA synthetase; Provisional; Region: PRK05431 885275002835 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 885275002836 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 885275002837 dimer interface [polypeptide binding]; other site 885275002838 active site 885275002839 motif 1; other site 885275002840 motif 2; other site 885275002841 motif 3; other site 885275002842 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 885275002843 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 885275002844 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 885275002845 putative [Fe4-S4] binding site [ion binding]; other site 885275002846 putative molybdopterin cofactor binding site [chemical binding]; other site 885275002847 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 885275002848 putative molybdopterin cofactor binding site; other site 885275002849 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 885275002850 4Fe-4S binding domain; Region: Fer4; pfam00037 885275002851 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 885275002852 Isochorismatase family; Region: Isochorismatase; pfam00857 885275002853 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 885275002854 catalytic triad [active] 885275002855 dimer interface [polypeptide binding]; other site 885275002856 conserved cis-peptide bond; other site 885275002857 putative MFS family transporter protein; Provisional; Region: PRK03633 885275002858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275002859 putative substrate translocation pore; other site 885275002860 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 885275002861 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885275002862 FeS/SAM binding site; other site 885275002863 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 885275002864 Pyruvate formate lyase 1; Region: PFL1; cd01678 885275002865 coenzyme A binding site [chemical binding]; other site 885275002866 active site 885275002867 catalytic residues [active] 885275002868 glycine loop; other site 885275002869 formate transporter; Provisional; Region: PRK10805 885275002870 uncharacterized domain; Region: TIGR00702 885275002871 YcaO-like family; Region: YcaO; pfam02624 885275002872 Predicted membrane protein [Function unknown]; Region: COG2323 885275002873 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 885275002874 homodimer interface [polypeptide binding]; other site 885275002875 substrate-cofactor binding pocket; other site 885275002876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275002877 catalytic residue [active] 885275002878 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 885275002879 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 885275002880 hinge; other site 885275002881 active site 885275002882 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 885275002883 cytidylate kinase; Provisional; Region: cmk; PRK00023 885275002884 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 885275002885 CMP-binding site; other site 885275002886 The sites determining sugar specificity; other site 885275002887 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 885275002888 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 885275002889 RNA binding site [nucleotide binding]; other site 885275002890 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 885275002891 RNA binding site [nucleotide binding]; other site 885275002892 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 885275002893 RNA binding site [nucleotide binding]; other site 885275002894 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 885275002895 RNA binding site [nucleotide binding]; other site 885275002896 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 885275002897 RNA binding site [nucleotide binding]; other site 885275002898 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 885275002899 IHF dimer interface [polypeptide binding]; other site 885275002900 IHF - DNA interface [nucleotide binding]; other site 885275002901 ComEC family competence protein; Provisional; Region: PRK11539 885275002902 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 885275002903 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 885275002904 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 885275002905 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 885275002906 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 885275002907 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 885275002908 Walker A/P-loop; other site 885275002909 ATP binding site [chemical binding]; other site 885275002910 Q-loop/lid; other site 885275002911 ABC transporter signature motif; other site 885275002912 Walker B; other site 885275002913 D-loop; other site 885275002914 H-loop/switch region; other site 885275002915 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 885275002916 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 885275002917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 885275002918 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 885275002919 hypothetical protein; Provisional; Region: PRK11827 885275002920 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 885275002921 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 885275002922 Ligand binding site; other site 885275002923 oligomer interface; other site 885275002924 hypothetical protein; Provisional; Region: PRK10593 885275002925 Uncharacterized conserved protein [Function unknown]; Region: COG1434 885275002926 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 885275002927 putative active site [active] 885275002928 Methyltransferase domain; Region: Methyltransf_31; pfam13847 885275002929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275002930 S-adenosylmethionine binding site [chemical binding]; other site 885275002931 condesin subunit F; Provisional; Region: PRK05260 885275002932 condesin subunit E; Provisional; Region: PRK05256 885275002933 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 885275002934 MukB N-terminal; Region: MukB; pfam04310 885275002935 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 885275002936 murein L,D-transpeptidase; Provisional; Region: PRK10594 885275002937 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 885275002938 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 885275002939 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 885275002940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 885275002941 Peptidase M15; Region: Peptidase_M15_3; cl01194 885275002942 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 885275002943 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 885275002944 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 885275002945 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275002946 homodimer interface [polypeptide binding]; other site 885275002947 catalytic residue [active] 885275002948 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 885275002949 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 885275002950 trimer interface [polypeptide binding]; other site 885275002951 eyelet of channel; other site 885275002952 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 885275002953 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 885275002954 putative dimer interface [polypeptide binding]; other site 885275002955 putative anticodon binding site; other site 885275002956 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 885275002957 homodimer interface [polypeptide binding]; other site 885275002958 motif 1; other site 885275002959 motif 2; other site 885275002960 active site 885275002961 motif 3; other site 885275002962 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 885275002963 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 885275002964 active site 885275002965 aminopeptidase N; Provisional; Region: pepN; PRK14015 885275002966 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 885275002967 active site 885275002968 Zn binding site [ion binding]; other site 885275002969 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 885275002970 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 885275002971 Walker A/P-loop; other site 885275002972 ATP binding site [chemical binding]; other site 885275002973 Q-loop/lid; other site 885275002974 ABC transporter signature motif; other site 885275002975 Walker B; other site 885275002976 D-loop; other site 885275002977 H-loop/switch region; other site 885275002978 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 885275002979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275002980 dimer interface [polypeptide binding]; other site 885275002981 conserved gate region; other site 885275002982 putative PBP binding loops; other site 885275002983 ABC-ATPase subunit interface; other site 885275002984 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 885275002985 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 885275002986 active site 885275002987 dimer interface [polypeptide binding]; other site 885275002988 non-prolyl cis peptide bond; other site 885275002989 insertion regions; other site 885275002990 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 885275002991 substrate binding pocket [chemical binding]; other site 885275002992 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 885275002993 membrane-bound complex binding site; other site 885275002994 hinge residues; other site 885275002995 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 885275002996 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 885275002997 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 885275002998 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 885275002999 quinone interaction residues [chemical binding]; other site 885275003000 active site 885275003001 catalytic residues [active] 885275003002 FMN binding site [chemical binding]; other site 885275003003 substrate binding site [chemical binding]; other site 885275003004 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 885275003005 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 885275003006 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 885275003007 MOSC domain; Region: MOSC; pfam03473 885275003008 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 885275003009 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 885275003010 catalytic loop [active] 885275003011 iron binding site [ion binding]; other site 885275003012 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 885275003013 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 885275003014 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 885275003015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275003016 S-adenosylmethionine binding site [chemical binding]; other site 885275003017 ABC transporter ATPase component; Reviewed; Region: PRK11147 885275003018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885275003019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885275003020 Walker A/P-loop; other site 885275003021 Walker A/P-loop; other site 885275003022 ATP binding site [chemical binding]; other site 885275003023 ATP binding site [chemical binding]; other site 885275003024 Q-loop/lid; other site 885275003025 Q-loop/lid; other site 885275003026 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 885275003027 ABC transporter signature motif; other site 885275003028 Walker B; other site 885275003029 D-loop; other site 885275003030 ABC transporter; Region: ABC_tran_2; pfam12848 885275003031 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 885275003032 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 885275003033 Paraquat-inducible protein A; Region: PqiA; pfam04403 885275003034 Paraquat-inducible protein A; Region: PqiA; pfam04403 885275003035 paraquat-inducible protein B; Provisional; Region: PRK10807 885275003036 mce related protein; Region: MCE; pfam02470 885275003037 mce related protein; Region: MCE; pfam02470 885275003038 mce related protein; Region: MCE; pfam02470 885275003039 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 885275003040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 885275003041 Protein of unknown function (DUF330); Region: DUF330; pfam03886 885275003042 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 885275003043 active site 1 [active] 885275003044 dimer interface [polypeptide binding]; other site 885275003045 active site 2 [active] 885275003046 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 885275003047 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 885275003048 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 885275003049 outer membrane protein A; Reviewed; Region: PRK10808 885275003050 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 885275003051 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 885275003052 ligand binding site [chemical binding]; other site 885275003053 SOS cell division inhibitor; Provisional; Region: PRK10595 885275003054 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 885275003055 TfoX C-terminal domain; Region: TfoX_C; pfam04994 885275003056 TIGR01666 family membrane protein; Region: YCCS 885275003057 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 885275003058 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 885275003059 Predicted membrane protein [Function unknown]; Region: COG3304 885275003060 Domain of unknown function (DUF307); Region: DUF307; pfam03733 885275003061 Domain of unknown function (DUF307); Region: DUF307; pfam03733 885275003062 DNA helicase IV; Provisional; Region: helD; PRK11054 885275003063 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 885275003064 Part of AAA domain; Region: AAA_19; pfam13245 885275003065 Family description; Region: UvrD_C_2; pfam13538 885275003066 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 885275003067 active site 885275003068 dimer interfaces [polypeptide binding]; other site 885275003069 catalytic residues [active] 885275003070 hypothetical protein; Provisional; Region: PRK03641 885275003071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 885275003072 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 885275003073 heat shock protein HspQ; Provisional; Region: PRK14129 885275003074 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 885275003075 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 885275003076 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 885275003077 putative RNA binding site [nucleotide binding]; other site 885275003078 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275003079 S-adenosylmethionine binding site [chemical binding]; other site 885275003080 acylphosphatase; Provisional; Region: PRK14439 885275003081 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 885275003082 sulfur transfer protein TusE; Provisional; Region: PRK11508 885275003083 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 885275003084 YccA-like proteins; Region: YccA_like; cd10433 885275003085 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 885275003086 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 885275003087 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 885275003088 hydrogenase 1 large subunit; Provisional; Region: PRK10170 885275003089 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 885275003090 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 885275003091 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 885275003092 putative substrate-binding site; other site 885275003093 nickel binding site [ion binding]; other site 885275003094 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 885275003095 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 885275003096 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 885275003097 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 885275003098 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 885275003099 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 885275003100 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 885275003101 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 885275003102 catalytic core [active] 885275003103 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 885275003104 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 885275003105 DNA-binding site [nucleotide binding]; DNA binding site 885275003106 RNA-binding motif; other site 885275003107 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 885275003108 DNA-binding site [nucleotide binding]; DNA binding site 885275003109 RNA-binding motif; other site 885275003110 cold shock gene; Provisional; Region: PRK09891 885275003111 GnsA/GnsB family; Region: GnsAB; pfam08178 885275003112 4Fe-4S binding domain; Region: Fer4_5; pfam12801 885275003113 4Fe-4S binding domain; Region: Fer4_5; pfam12801 885275003114 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 885275003115 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 885275003116 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 885275003117 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 885275003118 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 885275003119 dimerization interface [polypeptide binding]; other site 885275003120 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885275003121 dimer interface [polypeptide binding]; other site 885275003122 phosphorylation site [posttranslational modification] 885275003123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275003124 ATP binding site [chemical binding]; other site 885275003125 Mg2+ binding site [ion binding]; other site 885275003126 G-X-G motif; other site 885275003127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275003128 active site 885275003129 phosphorylation site [posttranslational modification] 885275003130 intermolecular recognition site; other site 885275003131 dimerization interface [polypeptide binding]; other site 885275003132 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 885275003133 putative binding surface; other site 885275003134 active site 885275003135 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 885275003136 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 885275003137 putative ligand binding site [chemical binding]; other site 885275003138 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 885275003139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275003140 active site 885275003141 phosphorylation site [posttranslational modification] 885275003142 intermolecular recognition site; other site 885275003143 dimerization interface [polypeptide binding]; other site 885275003144 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 885275003145 DNA binding site [nucleotide binding] 885275003146 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 885275003147 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 885275003148 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 885275003149 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 885275003150 molybdopterin cofactor binding site [chemical binding]; other site 885275003151 substrate binding site [chemical binding]; other site 885275003152 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 885275003153 molybdopterin cofactor binding site; other site 885275003154 chaperone protein TorD; Validated; Region: torD; PRK04976 885275003155 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 885275003156 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 885275003157 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 885275003158 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 885275003159 HSP70 interaction site [polypeptide binding]; other site 885275003160 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 885275003161 substrate binding site [polypeptide binding]; other site 885275003162 dimer interface [polypeptide binding]; other site 885275003163 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 885275003164 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 885275003165 catalytic core [active] 885275003166 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 885275003167 hypothetical protein; Provisional; Region: PRK10174 885275003168 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 885275003169 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 885275003170 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 885275003171 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 885275003172 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 885275003173 putative FMN binding site [chemical binding]; other site 885275003174 pyrimidine utilization protein D; Region: RutD; TIGR03611 885275003175 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 885275003176 homotrimer interaction site [polypeptide binding]; other site 885275003177 putative active site [active] 885275003178 Isochorismatase family; Region: Isochorismatase; pfam00857 885275003179 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 885275003180 catalytic triad [active] 885275003181 conserved cis-peptide bond; other site 885275003182 pyrimidine utilization protein A; Region: RutA; TIGR03612 885275003183 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 885275003184 active site 885275003185 dimer interface [polypeptide binding]; other site 885275003186 non-prolyl cis peptide bond; other site 885275003187 insertion regions; other site 885275003188 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 885275003189 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 885275003190 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 885275003191 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 885275003192 Predicted transcriptional regulator [Transcription]; Region: COG3905 885275003193 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 885275003194 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 885275003195 Glutamate binding site [chemical binding]; other site 885275003196 NAD binding site [chemical binding]; other site 885275003197 catalytic residues [active] 885275003198 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 885275003199 Na binding site [ion binding]; other site 885275003200 FTR1 family protein; Region: TIGR00145 885275003201 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 885275003202 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 885275003203 Imelysin; Region: Peptidase_M75; pfam09375 885275003204 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 885275003205 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 885275003206 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 885275003207 hypothetical protein; Provisional; Region: PRK10536 885275003208 putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585 885275003209 N-glycosyltransferase; Provisional; Region: PRK11204 885275003210 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 885275003211 DXD motif; other site 885275003212 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 885275003213 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 885275003214 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 885275003215 putative active site [active] 885275003216 putative metal binding site [ion binding]; other site 885275003217 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 885275003218 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 885275003219 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885275003220 metal binding site [ion binding]; metal-binding site 885275003221 active site 885275003222 I-site; other site 885275003223 integrase; Provisional; Region: PRK09692 885275003224 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 885275003225 active site 885275003226 Int/Topo IB signature motif; other site 885275003227 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 885275003228 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 885275003229 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 885275003230 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 885275003231 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 885275003232 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 885275003233 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 885275003234 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 885275003235 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 885275003236 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 885275003237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275003238 homodimer interface [polypeptide binding]; other site 885275003239 catalytic residue [active] 885275003240 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 885275003241 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 885275003242 putative active site [active] 885275003243 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 885275003244 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 885275003245 dimer interface [polypeptide binding]; other site 885275003246 active site 885275003247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 885275003248 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 885275003249 NAD(P) binding site [chemical binding]; other site 885275003250 active site 885275003251 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 885275003252 putative active site 1 [active] 885275003253 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 885275003254 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 885275003255 dimer interface [polypeptide binding]; other site 885275003256 active site 885275003257 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 885275003258 Predicted exporter [General function prediction only]; Region: COG4258 885275003259 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 885275003260 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 885275003261 active site 885275003262 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 885275003263 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 885275003264 Putative Catalytic site; other site 885275003265 DXD motif; other site 885275003266 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 885275003267 putative acyl-acceptor binding pocket; other site 885275003268 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 885275003269 active site 2 [active] 885275003270 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 885275003271 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 885275003272 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 885275003273 acyl-activating enzyme (AAE) consensus motif; other site 885275003274 acyl-activating enzyme (AAE) consensus motif; other site 885275003275 active site 885275003276 AMP binding site [chemical binding]; other site 885275003277 CoA binding site [chemical binding]; other site 885275003278 Predicted membrane protein [Function unknown]; Region: COG4648 885275003279 acyl carrier protein; Provisional; Region: PRK05350 885275003280 Phosphopantetheine attachment site; Region: PP-binding; cl09936 885275003281 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 885275003282 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 885275003283 putative acyl-acceptor binding pocket; other site 885275003284 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 885275003285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275003286 S-adenosylmethionine binding site [chemical binding]; other site 885275003287 potential frameshift: common BLAST hit: gi|110644687|ref|YP_672417.1| hemagglutinin-related protein 885275003288 adhesin HecA family 20-residue repeat (two copies); Region: fil_hemag_20aa; TIGR01731 885275003289 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 885275003290 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 885275003291 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 885275003292 Integrase core domain; Region: rve; pfam00665 885275003293 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 885275003294 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 885275003295 active site 885275003296 substrate binding site [chemical binding]; other site 885275003297 catalytic site [active] 885275003298 Transposase; Region: DDE_Tnp_ISL3; pfam01610 885275003299 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 885275003300 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 885275003301 Transposase; Region: DDE_Tnp_ISL3; pfam01610 885275003302 Helix-turn-helix domain; Region: HTH_38; pfam13936 885275003303 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12822 885275003304 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 885275003305 putative transposase OrfB; Reviewed; Region: PHA02517 885275003306 Integrase core domain; Region: rve; pfam00665 885275003307 Integrase core domain; Region: rve_2; pfam13333 885275003308 RTX toxin acyltransferase family; Region: HlyC; pfam02794 885275003309 HlyD family secretion protein; Region: HlyD; pfam00529 885275003310 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885275003311 HlyD family secretion protein; Region: HlyD_3; pfam13437 885275003312 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 885275003313 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 885275003314 putative active site [active] 885275003315 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 885275003316 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 885275003317 Walker A/P-loop; other site 885275003318 ATP binding site [chemical binding]; other site 885275003319 Q-loop/lid; other site 885275003320 ABC transporter signature motif; other site 885275003321 Walker B; other site 885275003322 D-loop; other site 885275003323 H-loop/switch region; other site 885275003324 CAAX protease self-immunity; Region: Abi; pfam02517 885275003325 FaeA-like protein; Region: FaeA; pfam04703 885275003326 Adhesin biosynthesis transcription regulatory protein; Region: PapB; pfam03333 885275003327 Fimbrial protein; Region: Fimbrial; cl01416 885275003328 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 885275003329 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 885275003330 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 885275003331 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 885275003332 outer membrane usher protein; Provisional; Region: PRK15193 885275003333 PapC N-terminal domain; Region: PapC_N; pfam13954 885275003334 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 885275003335 PapC C-terminal domain; Region: PapC_C; pfam13953 885275003336 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 885275003337 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 885275003338 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 885275003339 mannosyl binding site [chemical binding]; other site 885275003340 Fimbrial protein; Region: Fimbrial; pfam00419 885275003341 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885275003342 MarR family; Region: MarR_2; cl17246 885275003343 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 885275003344 Homeodomain-like domain; Region: HTH_23; pfam13384 885275003345 Winged helix-turn helix; Region: HTH_29; pfam13551 885275003346 Winged helix-turn helix; Region: HTH_33; pfam13592 885275003347 DDE superfamily endonuclease; Region: DDE_3; pfam13358 885275003348 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 885275003349 outer membrane receptor FepA; Provisional; Region: PRK13528 885275003350 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885275003351 N-terminal plug; other site 885275003352 ligand-binding site [chemical binding]; other site 885275003353 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 885275003354 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 885275003355 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 885275003356 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 885275003357 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 885275003358 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 885275003359 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885275003360 Walker A/P-loop; other site 885275003361 ATP binding site [chemical binding]; other site 885275003362 Q-loop/lid; other site 885275003363 ABC transporter signature motif; other site 885275003364 Walker B; other site 885275003365 D-loop; other site 885275003366 H-loop/switch region; other site 885275003367 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 885275003368 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 885275003369 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885275003370 Walker A/P-loop; other site 885275003371 ATP binding site [chemical binding]; other site 885275003372 Q-loop/lid; other site 885275003373 ABC transporter signature motif; other site 885275003374 Walker B; other site 885275003375 D-loop; other site 885275003376 H-loop/switch region; other site 885275003377 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 885275003378 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 885275003379 homodimer interface [polypeptide binding]; other site 885275003380 active site 885275003381 TDP-binding site; other site 885275003382 acceptor substrate-binding pocket; other site 885275003383 Transposase IS200 like; Region: Y1_Tnp; pfam01797 885275003384 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 885275003385 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 885275003386 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 885275003387 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885275003388 N-terminal plug; other site 885275003389 ligand-binding site [chemical binding]; other site 885275003390 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 885275003391 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 885275003392 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 885275003393 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 885275003394 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 885275003395 Sel1-like repeats; Region: SEL1; smart00671 885275003396 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 885275003397 Sel1-like repeats; Region: SEL1; smart00671 885275003398 Sel1-like repeats; Region: SEL1; smart00671 885275003399 Sel1-like repeats; Region: SEL1; smart00671 885275003400 Sel1-like repeats; Region: SEL1; smart00671 885275003401 Sel1-like repeats; Region: SEL1; smart00671 885275003402 Sel1-like repeats; Region: SEL1; smart00671 885275003403 Sel1-like repeats; Region: SEL1; smart00671 885275003404 Sel1-like repeats; Region: SEL1; smart00671 885275003405 HsdM N-terminal domain; Region: HsdM_N; pfam12161 885275003406 Predicted GTPase [General function prediction only]; Region: COG3596 885275003407 YfjP GTPase; Region: YfjP; cd11383 885275003408 G1 box; other site 885275003409 GTP/Mg2+ binding site [chemical binding]; other site 885275003410 Switch I region; other site 885275003411 G2 box; other site 885275003412 Switch II region; other site 885275003413 G3 box; other site 885275003414 G4 box; other site 885275003415 G5 box; other site 885275003416 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 885275003417 hypothetical protein; Provisional; Region: PRK09945 885275003418 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 885275003419 hypothetical protein; Provisional; Region: PRK09945 885275003420 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 885275003421 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 885275003422 Autotransporter beta-domain; Region: Autotransporter; smart00869 885275003423 Domain of unknown function (DUF932); Region: DUF932; pfam06067 885275003424 Antirestriction protein; Region: Antirestrict; pfam03230 885275003425 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 885275003426 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 885275003427 MPN+ (JAMM) motif; other site 885275003428 Zinc-binding site [ion binding]; other site 885275003429 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 885275003430 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 885275003431 Methyltransferase domain; Region: Methyltransf_27; pfam13708 885275003432 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 885275003433 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 885275003434 putative ligand binding site [chemical binding]; other site 885275003435 NAD binding site [chemical binding]; other site 885275003436 dimerization interface [polypeptide binding]; other site 885275003437 catalytic site [active] 885275003438 putative hydrolase; Validated; Region: PRK09248 885275003439 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 885275003440 active site 885275003441 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 885275003442 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 885275003443 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 885275003444 curli assembly protein CsgF; Provisional; Region: PRK10050 885275003445 curli assembly protein CsgE; Provisional; Region: PRK10386 885275003446 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 885275003447 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885275003448 DNA binding residues [nucleotide binding] 885275003449 dimerization interface [polypeptide binding]; other site 885275003450 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 885275003451 Curlin associated repeat; Region: Curlin_rpt; pfam07012 885275003452 Curlin associated repeat; Region: Curlin_rpt; pfam07012 885275003453 major curlin subunit; Provisional; Region: csgA; PRK10051 885275003454 Curlin associated repeat; Region: Curlin_rpt; pfam07012 885275003455 Curlin associated repeat; Region: Curlin_rpt; pfam07012 885275003456 Thin aggregative fimbriae synthesis protein; Region: Tafi-CsgC; pfam10610 885275003457 Fimbrial protein; Region: Fimbrial; cl01416 885275003458 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 885275003459 putative ADP-ribose binding site [chemical binding]; other site 885275003460 putative active site [active] 885275003461 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 885275003462 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 885275003463 putative active site [active] 885275003464 catalytic site [active] 885275003465 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 885275003466 putative active site [active] 885275003467 catalytic site [active] 885275003468 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 885275003469 Acyltransferase family; Region: Acyl_transf_3; pfam01757 885275003470 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 885275003471 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 885275003472 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 885275003473 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 885275003474 Ligand binding site; other site 885275003475 DXD motif; other site 885275003476 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 885275003477 lipoprotein; Provisional; Region: PRK10175 885275003478 secY/secA suppressor protein; Provisional; Region: PRK11467 885275003479 drug efflux system protein MdtG; Provisional; Region: PRK09874 885275003480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275003481 putative substrate translocation pore; other site 885275003482 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 885275003483 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 885275003484 putative acyl-acceptor binding pocket; other site 885275003485 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 885275003486 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 885275003487 active site residue [active] 885275003488 hypothetical protein; Provisional; Region: PRK03757 885275003489 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 885275003490 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 885275003491 hydroxyglutarate oxidase; Provisional; Region: PRK11728 885275003492 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 885275003493 DNA damage-inducible protein I; Provisional; Region: PRK10597 885275003494 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 885275003495 active site 885275003496 substrate binding pocket [chemical binding]; other site 885275003497 dimer interface [polypeptide binding]; other site 885275003498 lipoprotein; Provisional; Region: PRK10598 885275003499 glutaredoxin 2; Provisional; Region: PRK10387 885275003500 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 885275003501 C-terminal domain interface [polypeptide binding]; other site 885275003502 GSH binding site (G-site) [chemical binding]; other site 885275003503 catalytic residues [active] 885275003504 putative dimer interface [polypeptide binding]; other site 885275003505 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 885275003506 N-terminal domain interface [polypeptide binding]; other site 885275003507 multidrug resistance protein MdtH; Provisional; Region: PRK11646 885275003508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275003509 putative substrate translocation pore; other site 885275003510 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 885275003511 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 885275003512 hypothetical protein; Provisional; Region: PRK11239 885275003513 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 885275003514 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 885275003515 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 885275003516 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 885275003517 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 885275003518 MviN-like protein; Region: MVIN; pfam03023 885275003519 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 885275003520 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 885275003521 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 885275003522 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 885275003523 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 885275003524 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 885275003525 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 885275003526 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 885275003527 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 885275003528 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 885275003529 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 885275003530 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 885275003531 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 885275003532 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 885275003533 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 885275003534 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 885275003535 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 885275003536 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 885275003537 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 885275003538 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 885275003539 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 885275003540 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 885275003541 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 885275003542 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 885275003543 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 885275003544 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 885275003545 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 885275003546 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 885275003547 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 885275003548 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 885275003549 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 885275003550 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 885275003551 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 885275003552 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 885275003553 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 885275003554 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 885275003555 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 885275003556 homodimer interface [polypeptide binding]; other site 885275003557 oligonucleotide binding site [chemical binding]; other site 885275003558 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 885275003559 Protein of unknown function (DUF2655); Region: DUF2655; pfam10848 885275003560 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 885275003561 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 885275003562 RNA binding surface [nucleotide binding]; other site 885275003563 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 885275003564 active site 885275003565 Maf-like protein; Region: Maf; pfam02545 885275003566 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 885275003567 active site 885275003568 dimer interface [polypeptide binding]; other site 885275003569 hypothetical protein; Provisional; Region: PRK11193 885275003570 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 885275003571 putative phosphate acyltransferase; Provisional; Region: PRK05331 885275003572 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 885275003573 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 885275003574 dimer interface [polypeptide binding]; other site 885275003575 active site 885275003576 CoA binding pocket [chemical binding]; other site 885275003577 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 885275003578 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 885275003579 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 885275003580 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 885275003581 NAD(P) binding site [chemical binding]; other site 885275003582 homotetramer interface [polypeptide binding]; other site 885275003583 homodimer interface [polypeptide binding]; other site 885275003584 active site 885275003585 acyl carrier protein; Provisional; Region: acpP; PRK00982 885275003586 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 885275003587 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 885275003588 dimer interface [polypeptide binding]; other site 885275003589 active site 885275003590 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 885275003591 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 885275003592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275003593 catalytic residue [active] 885275003594 conserved hypothetical protein, YceG family; Region: TIGR00247 885275003595 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 885275003596 dimerization interface [polypeptide binding]; other site 885275003597 thymidylate kinase; Validated; Region: tmk; PRK00698 885275003598 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 885275003599 TMP-binding site; other site 885275003600 ATP-binding site [chemical binding]; other site 885275003601 DNA polymerase III subunit delta'; Validated; Region: PRK07993 885275003602 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 885275003603 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 885275003604 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 885275003605 active site 885275003606 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 885275003607 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 885275003608 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 885275003609 active site turn [active] 885275003610 phosphorylation site [posttranslational modification] 885275003611 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 885275003612 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885275003613 N-terminal plug; other site 885275003614 ligand-binding site [chemical binding]; other site 885275003615 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 885275003616 nucleotide binding site/active site [active] 885275003617 HIT family signature motif; other site 885275003618 catalytic residue [active] 885275003619 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 885275003620 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 885275003621 putative dimer interface [polypeptide binding]; other site 885275003622 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 885275003623 thiamine kinase; Region: ycfN_thiK; TIGR02721 885275003624 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 885275003625 active site 885275003626 substrate binding site [chemical binding]; other site 885275003627 ATP binding site [chemical binding]; other site 885275003628 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 885275003629 beta-hexosaminidase; Provisional; Region: PRK05337 885275003630 hypothetical protein; Provisional; Region: PRK04940 885275003631 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 885275003632 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 885275003633 hypothetical protein; Provisional; Region: PRK11280 885275003634 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 885275003635 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 885275003636 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 885275003637 L,D-transpeptidase; Provisional; Region: PRK10260 885275003638 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 885275003639 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 885275003640 transcription-repair coupling factor; Provisional; Region: PRK10689 885275003641 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 885275003642 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 885275003643 ATP binding site [chemical binding]; other site 885275003644 putative Mg++ binding site [ion binding]; other site 885275003645 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 885275003646 nucleotide binding region [chemical binding]; other site 885275003647 ATP-binding site [chemical binding]; other site 885275003648 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 885275003649 Predicted membrane protein [Function unknown]; Region: COG4763 885275003650 Acyltransferase family; Region: Acyl_transf_3; pfam01757 885275003651 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 885275003652 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 885275003653 FtsX-like permease family; Region: FtsX; pfam02687 885275003654 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 885275003655 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 885275003656 Walker A/P-loop; other site 885275003657 ATP binding site [chemical binding]; other site 885275003658 Q-loop/lid; other site 885275003659 ABC transporter signature motif; other site 885275003660 Walker B; other site 885275003661 D-loop; other site 885275003662 H-loop/switch region; other site 885275003663 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 885275003664 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 885275003665 FtsX-like permease family; Region: FtsX; pfam02687 885275003666 fructokinase; Reviewed; Region: PRK09557 885275003667 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 885275003668 nucleotide binding site [chemical binding]; other site 885275003669 NAD-dependent deacetylase; Provisional; Region: PRK00481 885275003670 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 885275003671 NAD+ binding site [chemical binding]; other site 885275003672 substrate binding site [chemical binding]; other site 885275003673 Zn binding site [ion binding]; other site 885275003674 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 885275003675 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 885275003676 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 885275003677 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 885275003678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275003679 dimer interface [polypeptide binding]; other site 885275003680 conserved gate region; other site 885275003681 putative PBP binding loops; other site 885275003682 ABC-ATPase subunit interface; other site 885275003683 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 885275003684 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 885275003685 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 885275003686 dimer interface [polypeptide binding]; other site 885275003687 active site 885275003688 Int/Topo IB signature motif; other site 885275003689 exonuclease VIII; Reviewed; Region: PRK09709 885275003690 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 885275003691 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 885275003692 active site 885275003693 catalytic site [active] 885275003694 substrate binding site [chemical binding]; other site 885275003695 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 885275003696 DicB protein; Region: DicB; pfam05358 885275003697 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 885275003698 transcriptional repressor DicA; Reviewed; Region: PRK09706 885275003699 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 885275003700 primosomal protein DnaI; Provisional; Region: PRK02854 885275003701 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 885275003702 Protein of unknown function (DUF968); Region: DUF968; pfam06147 885275003703 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 885275003704 Antitermination protein; Region: Antiterm; pfam03589 885275003705 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 885275003706 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 885275003707 anti-adapter protein IraM; Provisional; Region: PRK09919 885275003708 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 885275003709 Lysis protein S; Region: Lysis_S; pfam04971 885275003710 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 885275003711 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 885275003712 catalytic residues [active] 885275003713 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 885275003714 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 885275003715 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 885275003716 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 885275003717 Phage DNA packaging protein, Nu1 subunit of terminase [DNA replication, recombination, and repair]; Region: COG4220 885275003718 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 885275003719 gpW; Region: gpW; pfam02831 885275003720 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 885275003721 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 885275003722 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 885275003723 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 885275003724 tandem repeat interface [polypeptide binding]; other site 885275003725 oligomer interface [polypeptide binding]; other site 885275003726 active site residues [active] 885275003727 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 885275003728 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 885275003729 DNA packaging protein FI; Region: Packaging_FI; pfam14000 885275003730 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 885275003731 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 885275003732 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 885275003733 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 885275003734 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 885275003735 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 885275003736 phage tail assembly protein T; Region: phage_lam_T; TIGR01715 885275003737 Phage-related minor tail protein [Function unknown]; Region: COG5281 885275003738 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 885275003739 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 885275003740 Phage-related protein [Function unknown]; Region: COG4718 885275003741 Phage-related protein [Function unknown]; Region: gp18; COG4672 885275003742 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 885275003743 MPN+ (JAMM) motif; other site 885275003744 Zinc-binding site [ion binding]; other site 885275003745 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 885275003746 NlpC/P60 family; Region: NLPC_P60; cl17555 885275003747 Phage-related protein, tail component [Function unknown]; Region: COG4723 885275003748 Phage-related protein, tail component [Function unknown]; Region: COG4733 885275003749 Putative phage tail protein; Region: Phage-tail_3; pfam13550 885275003750 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 885275003751 Interdomain contacts; other site 885275003752 Cytokine receptor motif; other site 885275003753 Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811 885275003754 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 885275003755 Fibronectin type III protein; Region: DUF3672; pfam12421 885275003756 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 885275003757 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 885275003758 Methyltransferase domain; Region: Methyltransf_12; pfam08242 885275003759 S-adenosylmethionine binding site [chemical binding]; other site 885275003760 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 885275003761 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 885275003762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275003763 dimer interface [polypeptide binding]; other site 885275003764 conserved gate region; other site 885275003765 putative PBP binding loops; other site 885275003766 ABC-ATPase subunit interface; other site 885275003767 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 885275003768 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885275003769 Walker A/P-loop; other site 885275003770 ATP binding site [chemical binding]; other site 885275003771 Q-loop/lid; other site 885275003772 ABC transporter signature motif; other site 885275003773 Walker B; other site 885275003774 D-loop; other site 885275003775 H-loop/switch region; other site 885275003776 TOBE domain; Region: TOBE_2; pfam08402 885275003777 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 885275003778 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 885275003779 metal binding site [ion binding]; metal-binding site 885275003780 dimer interface [polypeptide binding]; other site 885275003781 Uncharacterized conserved protein [Function unknown]; Region: COG2850 885275003782 Cupin-like domain; Region: Cupin_8; pfam13621 885275003783 sensor protein PhoQ; Provisional; Region: PRK10815 885275003784 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 885275003785 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 885275003786 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 885275003787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275003788 ATP binding site [chemical binding]; other site 885275003789 Mg2+ binding site [ion binding]; other site 885275003790 G-X-G motif; other site 885275003791 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 885275003792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275003793 active site 885275003794 phosphorylation site [posttranslational modification] 885275003795 intermolecular recognition site; other site 885275003796 dimerization interface [polypeptide binding]; other site 885275003797 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 885275003798 DNA binding site [nucleotide binding] 885275003799 adenylosuccinate lyase; Provisional; Region: PRK09285 885275003800 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 885275003801 tetramer interface [polypeptide binding]; other site 885275003802 active site 885275003803 putative lysogenization regulator; Reviewed; Region: PRK00218 885275003804 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 885275003805 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 885275003806 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 885275003807 nudix motif; other site 885275003808 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 885275003809 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 885275003810 probable active site [active] 885275003811 isocitrate dehydrogenase; Validated; Region: PRK07362 885275003812 isocitrate dehydrogenase; Reviewed; Region: PRK07006 885275003813 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 885275003814 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 885275003815 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 885275003816 dimer interface [polypeptide binding]; other site 885275003817 active site 885275003818 Int/Topo IB signature motif; other site 885275003819 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 885275003820 ASCH domain; Region: ASCH; pfam04266 885275003821 Protein of unknown function (DUF550); Region: DUF550; pfam04447 885275003822 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 885275003823 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 885275003824 Protein of unknown function (DUF1317); Region: DUF1317; pfam07026 885275003825 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 885275003826 phage recombination protein Bet; Region: bet_lambda; TIGR01913 885275003827 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 885275003828 Lambda Phage CIII; Region: Lambda_CIII; pfam02061 885275003829 Protein of unknown function (DUF2528); Region: DUF2528; pfam10800 885275003830 Antirestriction protein Ral; Region: Ral; pfam11058 885275003831 Superinfection exclusion protein B; Region: SieB; pfam14163 885275003832 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 885275003833 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 885275003834 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 885275003835 non-specific DNA binding site [nucleotide binding]; other site 885275003836 salt bridge; other site 885275003837 sequence-specific DNA binding site [nucleotide binding]; other site 885275003838 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 885275003839 Catalytic site [active] 885275003840 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 885275003841 non-specific DNA binding site [nucleotide binding]; other site 885275003842 salt bridge; other site 885275003843 sequence-specific DNA binding site [nucleotide binding]; other site 885275003844 Bacteriophage CII protein; Region: Phage_CII; pfam05269 885275003845 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 885275003846 Replication protein P; Region: Phage_lambda_P; pfam06992 885275003847 NinB protein; Region: NinB; pfam05772 885275003848 phage N-6-adenine-methyltransferase; Region: phage_N6A_met; TIGR01712 885275003849 hypothetical protein; Region: PHA01519 885275003850 endodeoxyribonuclease RUS; Reviewed; Region: PRK09786 885275003851 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 885275003852 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 885275003853 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 885275003854 trimer interface [polypeptide binding]; other site 885275003855 eyelet of channel; other site 885275003856 Lysis protein S; Region: Lysis_S; pfam04971 885275003857 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 885275003858 catalytic residues [active] 885275003859 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 885275003860 Bor protein; Region: Lambda_Bor; pfam06291 885275003861 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 885275003862 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 885275003863 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 885275003864 gpW; Region: gpW; pfam02831 885275003865 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 885275003866 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 885275003867 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 885275003868 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 885275003869 DNA packaging protein FI; Region: Packaging_FI; pfam14000 885275003870 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 885275003871 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 885275003872 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 885275003873 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 885275003874 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 885275003875 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 885275003876 Minor tail protein T; Region: Phage_tail_T; cl05636 885275003877 Phage-related minor tail protein [Function unknown]; Region: COG5281 885275003878 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 885275003879 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 885275003880 Phage-related protein [Function unknown]; Region: COG4718 885275003881 Phage-related protein [Function unknown]; Region: gp18; COG4672 885275003882 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 885275003883 MPN+ (JAMM) motif; other site 885275003884 Zinc-binding site [ion binding]; other site 885275003885 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 885275003886 NlpC/P60 family; Region: NLPC_P60; cl17555 885275003887 Phage-related protein, tail component [Function unknown]; Region: COG4723 885275003888 Phage-related protein, tail component [Function unknown]; Region: COG4733 885275003889 Putative phage tail protein; Region: Phage-tail_3; pfam13550 885275003890 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 885275003891 Interdomain contacts; other site 885275003892 Cytokine receptor motif; other site 885275003893 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 885275003894 Fibronectin type III protein; Region: DUF3672; pfam12421 885275003895 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 885275003896 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 885275003897 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 885275003898 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 885275003899 ABC-ATPase subunit interface; other site 885275003900 dimer interface [polypeptide binding]; other site 885275003901 putative PBP binding regions; other site 885275003902 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 885275003903 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 885275003904 ABC-ATPase subunit interface; other site 885275003905 dimer interface [polypeptide binding]; other site 885275003906 putative PBP binding regions; other site 885275003907 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 885275003908 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 885275003909 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 885275003910 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 885275003911 metal binding site [ion binding]; metal-binding site 885275003912 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 885275003913 transcriptional regulator MirA; Provisional; Region: PRK15043 885275003914 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 885275003915 DNA binding residues [nucleotide binding] 885275003916 Sensors of blue-light using FAD; Region: BLUF; smart01034 885275003917 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885275003918 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 885275003919 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 885275003920 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885275003921 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 885275003922 Autotransporter beta-domain; Region: Autotransporter; cl17461 885275003923 Autotransporter beta-domain; Region: Autotransporter; smart00869 885275003924 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 885275003925 cell division inhibitor MinD; Provisional; Region: PRK10818 885275003926 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 885275003927 Switch I; other site 885275003928 Switch II; other site 885275003929 septum formation inhibitor; Reviewed; Region: minC; PRK03511 885275003930 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 885275003931 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 885275003932 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 885275003933 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 885275003934 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 885275003935 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 885275003936 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 885275003937 hypothetical protein; Provisional; Region: PRK10691 885275003938 hypothetical protein; Provisional; Region: PRK05170 885275003939 Haemolysin E (HlyE); Region: HlyE; cl11627 885275003940 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 885275003941 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 885275003942 Catalytic site [active] 885275003943 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 885275003944 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 885275003945 active site 885275003946 DNA binding site [nucleotide binding] 885275003947 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 885275003948 disulfide bond formation protein B; Provisional; Region: PRK01749 885275003949 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 885275003950 transmembrane helices; other site 885275003951 fatty acid metabolism regulator; Provisional; Region: PRK04984 885275003952 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885275003953 DNA-binding site [nucleotide binding]; DNA binding site 885275003954 FadR C-terminal domain; Region: FadR_C; pfam07840 885275003955 SpoVR family protein; Provisional; Region: PRK11767 885275003956 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 885275003957 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 885275003958 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 885275003959 alanine racemase; Reviewed; Region: dadX; PRK03646 885275003960 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 885275003961 active site 885275003962 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 885275003963 substrate binding site [chemical binding]; other site 885275003964 catalytic residues [active] 885275003965 dimer interface [polypeptide binding]; other site 885275003966 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 885275003967 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 885275003968 TrkA-C domain; Region: TrkA_C; pfam02080 885275003969 Transporter associated domain; Region: CorC_HlyC; smart01091 885275003970 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 885275003971 dimer interface [polypeptide binding]; other site 885275003972 catalytic triad [active] 885275003973 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 885275003974 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 885275003975 N-acetyl-D-glucosamine binding site [chemical binding]; other site 885275003976 catalytic residue [active] 885275003977 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 885275003978 Flagellar regulator YcgR; Region: YcgR; pfam07317 885275003979 PilZ domain; Region: PilZ; pfam07238 885275003980 hypothetical protein; Provisional; Region: PRK10457 885275003981 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885275003982 N-terminal plug; other site 885275003983 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 885275003984 ligand-binding site [chemical binding]; other site 885275003985 molybdenum transport protein ModD; Provisional; Region: PRK06096 885275003986 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 885275003987 dimerization interface [polypeptide binding]; other site 885275003988 active site 885275003989 Methyltransferase domain; Region: Methyltransf_31; pfam13847 885275003990 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275003991 S-adenosylmethionine binding site [chemical binding]; other site 885275003992 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 885275003993 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 885275003994 Walker A/P-loop; other site 885275003995 ATP binding site [chemical binding]; other site 885275003996 Q-loop/lid; other site 885275003997 ABC transporter signature motif; other site 885275003998 Walker B; other site 885275003999 D-loop; other site 885275004000 H-loop/switch region; other site 885275004001 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 885275004002 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 885275004003 ABC-ATPase subunit interface; other site 885275004004 dimer interface [polypeptide binding]; other site 885275004005 putative PBP binding regions; other site 885275004006 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 885275004007 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 885275004008 putative metal binding site [ion binding]; other site 885275004009 trehalase; Provisional; Region: treA; PRK13271 885275004010 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 885275004011 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 885275004012 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 885275004013 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 885275004014 dimerization domain swap beta strand [polypeptide binding]; other site 885275004015 regulatory protein interface [polypeptide binding]; other site 885275004016 active site 885275004017 regulatory phosphorylation site [posttranslational modification]; other site 885275004018 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 885275004019 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 885275004020 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 885275004021 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 885275004022 Dak1 domain; Region: Dak1; pfam02733 885275004023 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 885275004024 PAS domain; Region: PAS; smart00091 885275004025 putative active site [active] 885275004026 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275004027 Walker A motif; other site 885275004028 ATP binding site [chemical binding]; other site 885275004029 Walker B motif; other site 885275004030 arginine finger; other site 885275004031 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 885275004032 Probable pectinesterase/pectinesterase inhibitor; Region: PLN02708 885275004033 GTP-binding protein YchF; Reviewed; Region: PRK09601 885275004034 YchF GTPase; Region: YchF; cd01900 885275004035 G1 box; other site 885275004036 GTP/Mg2+ binding site [chemical binding]; other site 885275004037 Switch I region; other site 885275004038 G2 box; other site 885275004039 Switch II region; other site 885275004040 G3 box; other site 885275004041 G4 box; other site 885275004042 G5 box; other site 885275004043 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 885275004044 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 885275004045 putative active site [active] 885275004046 catalytic residue [active] 885275004047 hypothetical protein; Provisional; Region: PRK10692 885275004048 putative transporter; Provisional; Region: PRK11660 885275004049 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 885275004050 Sulfate transporter family; Region: Sulfate_transp; pfam00916 885275004051 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 885275004052 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 885275004053 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 885275004054 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 885275004055 active site 885275004056 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 885275004057 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 885275004058 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 885275004059 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 885275004060 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 885275004061 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 885275004062 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 885275004063 tRNA; other site 885275004064 putative tRNA binding site [nucleotide binding]; other site 885275004065 putative NADP binding site [chemical binding]; other site 885275004066 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 885275004067 peptide chain release factor 1; Validated; Region: prfA; PRK00591 885275004068 This domain is found in peptide chain release factors; Region: PCRF; smart00937 885275004069 RF-1 domain; Region: RF-1; pfam00472 885275004070 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 885275004071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275004072 hypothetical protein; Provisional; Region: PRK10278 885275004073 hypothetical protein; Provisional; Region: PRK10941 885275004074 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 885275004075 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 885275004076 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 885275004077 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 885275004078 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 885275004079 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 885275004080 cation transport regulator; Reviewed; Region: chaB; PRK09582 885275004081 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 885275004082 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 885275004083 putative active site pocket [active] 885275004084 dimerization interface [polypeptide binding]; other site 885275004085 putative catalytic residue [active] 885275004086 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 885275004087 putative invasin; Provisional; Region: PRK10177 885275004088 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 885275004089 transcriptional regulator NarL; Provisional; Region: PRK10651 885275004090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275004091 active site 885275004092 phosphorylation site [posttranslational modification] 885275004093 intermolecular recognition site; other site 885275004094 dimerization interface [polypeptide binding]; other site 885275004095 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885275004096 DNA binding residues [nucleotide binding] 885275004097 dimerization interface [polypeptide binding]; other site 885275004098 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 885275004099 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 885275004100 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 885275004101 dimerization interface [polypeptide binding]; other site 885275004102 Histidine kinase; Region: HisKA_3; pfam07730 885275004103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275004104 ATP binding site [chemical binding]; other site 885275004105 Mg2+ binding site [ion binding]; other site 885275004106 G-X-G motif; other site 885275004107 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 885275004108 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 885275004109 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 885275004110 [4Fe-4S] binding site [ion binding]; other site 885275004111 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 885275004112 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 885275004113 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 885275004114 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 885275004115 molybdopterin cofactor binding site; other site 885275004116 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 885275004117 4Fe-4S binding domain; Region: Fer4; cl02805 885275004118 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 885275004119 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 885275004120 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 885275004121 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 885275004122 dimer interface [polypeptide binding]; other site 885275004123 active site 885275004124 CoA binding pocket [chemical binding]; other site 885275004125 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 885275004126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 885275004127 NAD(P) binding site [chemical binding]; other site 885275004128 active site 885275004129 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 885275004130 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 885275004131 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 885275004132 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 885275004133 active site 885275004134 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 885275004135 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 885275004136 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 885275004137 putative di-iron ligands [ion binding]; other site 885275004138 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 885275004139 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 885275004140 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 885275004141 putative active site [active] 885275004142 putative substrate binding site [chemical binding]; other site 885275004143 putative cosubstrate binding site; other site 885275004144 catalytic site [active] 885275004145 SEC-C motif; Region: SEC-C; pfam02810 885275004146 hypothetical protein; Provisional; Region: PRK04233 885275004147 hypothetical protein; Provisional; Region: PRK10279 885275004148 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 885275004149 active site 885275004150 nucleophile elbow; other site 885275004151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275004152 active site 885275004153 response regulator of RpoS; Provisional; Region: PRK10693 885275004154 phosphorylation site [posttranslational modification] 885275004155 intermolecular recognition site; other site 885275004156 dimerization interface [polypeptide binding]; other site 885275004157 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 885275004158 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 885275004159 active site 885275004160 tetramer interface; other site 885275004161 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 885275004162 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 885275004163 thymidine kinase; Provisional; Region: PRK04296 885275004164 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 885275004165 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 885275004166 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 885275004167 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 885275004168 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 885275004169 putative catalytic cysteine [active] 885275004170 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 885275004171 putative active site [active] 885275004172 metal binding site [ion binding]; metal-binding site 885275004173 hypothetical protein; Provisional; Region: PRK11111 885275004174 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 885275004175 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 885275004176 peptide binding site [polypeptide binding]; other site 885275004177 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 885275004178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275004179 dimer interface [polypeptide binding]; other site 885275004180 conserved gate region; other site 885275004181 putative PBP binding loops; other site 885275004182 ABC-ATPase subunit interface; other site 885275004183 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 885275004184 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 885275004185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275004186 dimer interface [polypeptide binding]; other site 885275004187 conserved gate region; other site 885275004188 putative PBP binding loops; other site 885275004189 ABC-ATPase subunit interface; other site 885275004190 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 885275004191 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 885275004192 Walker A/P-loop; other site 885275004193 ATP binding site [chemical binding]; other site 885275004194 Q-loop/lid; other site 885275004195 ABC transporter signature motif; other site 885275004196 Walker B; other site 885275004197 D-loop; other site 885275004198 H-loop/switch region; other site 885275004199 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 885275004200 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 885275004201 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 885275004202 Walker A/P-loop; other site 885275004203 ATP binding site [chemical binding]; other site 885275004204 Q-loop/lid; other site 885275004205 ABC transporter signature motif; other site 885275004206 Walker B; other site 885275004207 D-loop; other site 885275004208 H-loop/switch region; other site 885275004209 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 885275004210 dsDNA-mimic protein; Reviewed; Region: PRK05094 885275004211 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 885275004212 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 885275004213 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 885275004214 putative active site [active] 885275004215 catalytic site [active] 885275004216 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 885275004217 putative active site [active] 885275004218 catalytic site [active] 885275004219 voltage-gated potassium channel; Provisional; Region: PRK10537 885275004220 Ion channel; Region: Ion_trans_2; pfam07885 885275004221 TrkA-N domain; Region: TrkA_N; pfam02254 885275004222 YciI-like protein; Reviewed; Region: PRK11370 885275004223 transport protein TonB; Provisional; Region: PRK10819 885275004224 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 885275004225 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 885275004226 intracellular septation protein A; Reviewed; Region: PRK00259 885275004227 hypothetical protein; Provisional; Region: PRK02868 885275004228 outer membrane protein W; Provisional; Region: PRK10959 885275004229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 885275004230 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 885275004231 dimerization interface [polypeptide binding]; other site 885275004232 metal binding site [ion binding]; metal-binding site 885275004233 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 885275004234 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 885275004235 substrate binding site [chemical binding]; other site 885275004236 active site 885275004237 catalytic residues [active] 885275004238 heterodimer interface [polypeptide binding]; other site 885275004239 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 885275004240 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 885275004241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275004242 catalytic residue [active] 885275004243 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 885275004244 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 885275004245 active site 885275004246 ribulose/triose binding site [chemical binding]; other site 885275004247 phosphate binding site [ion binding]; other site 885275004248 substrate (anthranilate) binding pocket [chemical binding]; other site 885275004249 product (indole) binding pocket [chemical binding]; other site 885275004250 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 885275004251 active site 885275004252 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 885275004253 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 885275004254 glutamine binding [chemical binding]; other site 885275004255 catalytic triad [active] 885275004256 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 885275004257 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 885275004258 anthranilate synthase component I; Provisional; Region: PRK13564 885275004259 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 885275004260 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 885275004261 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 885275004262 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 885275004263 active site 885275004264 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 885275004265 hypothetical protein; Provisional; Region: PRK11630 885275004266 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 885275004267 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 885275004268 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 885275004269 RNA binding surface [nucleotide binding]; other site 885275004270 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 885275004271 probable active site [active] 885275004272 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 885275004273 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 885275004274 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 885275004275 homodimer interface [polypeptide binding]; other site 885275004276 Walker A motif; other site 885275004277 ATP binding site [chemical binding]; other site 885275004278 hydroxycobalamin binding site [chemical binding]; other site 885275004279 Walker B motif; other site 885275004280 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 885275004281 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 885275004282 NADP binding site [chemical binding]; other site 885275004283 homodimer interface [polypeptide binding]; other site 885275004284 active site 885275004285 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 885275004286 putative inner membrane peptidase; Provisional; Region: PRK11778 885275004287 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 885275004288 tandem repeat interface [polypeptide binding]; other site 885275004289 oligomer interface [polypeptide binding]; other site 885275004290 active site residues [active] 885275004291 hypothetical protein; Provisional; Region: PRK11037 885275004292 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 885275004293 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 885275004294 active site 885275004295 interdomain interaction site; other site 885275004296 putative metal-binding site [ion binding]; other site 885275004297 nucleotide binding site [chemical binding]; other site 885275004298 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 885275004299 domain I; other site 885275004300 DNA binding groove [nucleotide binding] 885275004301 phosphate binding site [ion binding]; other site 885275004302 domain II; other site 885275004303 domain III; other site 885275004304 nucleotide binding site [chemical binding]; other site 885275004305 catalytic site [active] 885275004306 domain IV; other site 885275004307 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 885275004308 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 885275004309 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 885275004310 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 885275004311 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 885275004312 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275004313 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 885275004314 substrate binding site [chemical binding]; other site 885275004315 putative dimerization interface [polypeptide binding]; other site 885275004316 aconitate hydratase; Validated; Region: PRK09277 885275004317 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 885275004318 substrate binding site [chemical binding]; other site 885275004319 ligand binding site [chemical binding]; other site 885275004320 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 885275004321 substrate binding site [chemical binding]; other site 885275004322 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 885275004323 dimerization interface [polypeptide binding]; other site 885275004324 active site 885275004325 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 885275004326 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 885275004327 active site 885275004328 Predicted membrane protein [Function unknown]; Region: COG3771 885275004329 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 885275004330 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 885275004331 TPR motif; other site 885275004332 binding surface 885275004333 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 885275004334 binding surface 885275004335 TPR motif; other site 885275004336 translation initiation factor Sui1; Validated; Region: PRK06824 885275004337 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 885275004338 putative rRNA binding site [nucleotide binding]; other site 885275004339 lipoprotein; Provisional; Region: PRK10540 885275004340 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 885275004341 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 885275004342 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 885275004343 hypothetical protein; Provisional; Region: PRK13658 885275004344 RNase II stability modulator; Provisional; Region: PRK10060 885275004345 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 885275004346 putative active site [active] 885275004347 heme pocket [chemical binding]; other site 885275004348 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885275004349 metal binding site [ion binding]; metal-binding site 885275004350 active site 885275004351 I-site; other site 885275004352 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885275004353 exoribonuclease II; Provisional; Region: PRK05054 885275004354 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 885275004355 RNB domain; Region: RNB; pfam00773 885275004356 S1 RNA binding domain; Region: S1; pfam00575 885275004357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 885275004358 Uncharacterized conserved protein [Function unknown]; Region: COG2128 885275004359 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 885275004360 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 885275004361 NAD binding site [chemical binding]; other site 885275004362 homotetramer interface [polypeptide binding]; other site 885275004363 homodimer interface [polypeptide binding]; other site 885275004364 substrate binding site [chemical binding]; other site 885275004365 active site 885275004366 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 885275004367 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 885275004368 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 885275004369 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885275004370 HlyD family secretion protein; Region: HlyD_3; pfam13437 885275004371 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 885275004372 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 885275004373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275004374 putative substrate translocation pore; other site 885275004375 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 885275004376 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 885275004377 Walker A/P-loop; other site 885275004378 ATP binding site [chemical binding]; other site 885275004379 Q-loop/lid; other site 885275004380 ABC transporter signature motif; other site 885275004381 Walker B; other site 885275004382 D-loop; other site 885275004383 H-loop/switch region; other site 885275004384 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 885275004385 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 885275004386 Walker A/P-loop; other site 885275004387 ATP binding site [chemical binding]; other site 885275004388 Q-loop/lid; other site 885275004389 ABC transporter signature motif; other site 885275004390 Walker B; other site 885275004391 D-loop; other site 885275004392 H-loop/switch region; other site 885275004393 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 885275004394 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 885275004395 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 885275004396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275004397 dimer interface [polypeptide binding]; other site 885275004398 conserved gate region; other site 885275004399 putative PBP binding loops; other site 885275004400 ABC-ATPase subunit interface; other site 885275004401 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 885275004402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275004403 dimer interface [polypeptide binding]; other site 885275004404 conserved gate region; other site 885275004405 putative PBP binding loops; other site 885275004406 ABC-ATPase subunit interface; other site 885275004407 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 885275004408 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 885275004409 peptide binding site [polypeptide binding]; other site 885275004410 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 885275004411 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 885275004412 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275004413 Walker A motif; other site 885275004414 ATP binding site [chemical binding]; other site 885275004415 Walker B motif; other site 885275004416 arginine finger; other site 885275004417 phage shock protein PspA; Provisional; Region: PRK10698 885275004418 phage shock protein B; Provisional; Region: pspB; PRK09458 885275004419 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 885275004420 phage shock protein C; Region: phageshock_pspC; TIGR02978 885275004421 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 885275004422 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 885275004423 active site residue [active] 885275004424 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 885275004425 sucrose phosphorylase; Provisional; Region: PRK13840 885275004426 active site 885275004427 homodimer interface [polypeptide binding]; other site 885275004428 catalytic site [active] 885275004429 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 885275004430 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 885275004431 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 885275004432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275004433 dimer interface [polypeptide binding]; other site 885275004434 conserved gate region; other site 885275004435 putative PBP binding loops; other site 885275004436 ABC-ATPase subunit interface; other site 885275004437 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 885275004438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275004439 dimer interface [polypeptide binding]; other site 885275004440 conserved gate region; other site 885275004441 putative PBP binding loops; other site 885275004442 ABC-ATPase subunit interface; other site 885275004443 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 885275004444 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 885275004445 putative NAD(P) binding site [chemical binding]; other site 885275004446 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 885275004447 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 885275004448 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 885275004449 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 885275004450 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 885275004451 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 885275004452 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 885275004453 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 885275004454 beta-phosphoglucomutase; Region: bPGM; TIGR01990 885275004455 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885275004456 motif II; other site 885275004457 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 885275004458 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 885275004459 Walker A/P-loop; other site 885275004460 ATP binding site [chemical binding]; other site 885275004461 Q-loop/lid; other site 885275004462 ABC transporter signature motif; other site 885275004463 Walker B; other site 885275004464 D-loop; other site 885275004465 H-loop/switch region; other site 885275004466 TOBE domain; Region: TOBE_2; pfam08402 885275004467 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 885275004468 Transcriptional regulators [Transcription]; Region: PurR; COG1609 885275004469 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 885275004470 DNA binding site [nucleotide binding] 885275004471 domain linker motif; other site 885275004472 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 885275004473 putative dimerization interface [polypeptide binding]; other site 885275004474 putative ligand binding site [chemical binding]; other site 885275004475 Predicted ATPase [General function prediction only]; Region: COG3106 885275004476 hypothetical protein; Provisional; Region: PRK05415 885275004477 TIGR01620 family protein; Region: hyp_HI0043 885275004478 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 885275004479 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 885275004480 putative aromatic amino acid binding site; other site 885275004481 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275004482 Walker A motif; other site 885275004483 ATP binding site [chemical binding]; other site 885275004484 Walker B motif; other site 885275004485 arginine finger; other site 885275004486 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 885275004487 dimer interface [polypeptide binding]; other site 885275004488 catalytic triad [active] 885275004489 peroxidatic and resolving cysteines [active] 885275004490 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 885275004491 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 885275004492 active site 885275004493 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 885275004494 NADH(P)-binding; Region: NAD_binding_10; pfam13460 885275004495 putative NAD(P) binding site [chemical binding]; other site 885275004496 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 885275004497 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 885275004498 Transcriptional regulator [Transcription]; Region: LysR; COG0583 885275004499 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275004500 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 885275004501 putative effector binding pocket; other site 885275004502 putative dimerization interface [polypeptide binding]; other site 885275004503 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 885275004504 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 885275004505 peptide binding site [polypeptide binding]; other site 885275004506 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 885275004507 Mechanosensitive ion channel; Region: MS_channel; pfam00924 885275004508 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 885275004509 universal stress protein UspE; Provisional; Region: PRK11175 885275004510 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 885275004511 Ligand Binding Site [chemical binding]; other site 885275004512 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 885275004513 Ligand Binding Site [chemical binding]; other site 885275004514 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 885275004515 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 885275004516 ligand binding site [chemical binding]; other site 885275004517 flexible hinge region; other site 885275004518 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 885275004519 putative switch regulator; other site 885275004520 non-specific DNA interactions [nucleotide binding]; other site 885275004521 DNA binding site [nucleotide binding] 885275004522 sequence specific DNA binding site [nucleotide binding]; other site 885275004523 putative cAMP binding site [chemical binding]; other site 885275004524 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 885275004525 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 885275004526 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 885275004527 DNA binding site [nucleotide binding] 885275004528 active site 885275004529 Cupin domain; Region: Cupin_2; cl17218 885275004530 Helix-turn-helix domain; Region: HTH_18; pfam12833 885275004531 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885275004532 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 885275004533 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 885275004534 Smr domain; Region: Smr; pfam01713 885275004535 PAS domain S-box; Region: sensory_box; TIGR00229 885275004536 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 885275004537 putative active site [active] 885275004538 heme pocket [chemical binding]; other site 885275004539 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 885275004540 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885275004541 metal binding site [ion binding]; metal-binding site 885275004542 active site 885275004543 I-site; other site 885275004544 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 885275004545 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 885275004546 Cl binding site [ion binding]; other site 885275004547 oligomer interface [polypeptide binding]; other site 885275004548 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 885275004549 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 885275004550 ATP binding site [chemical binding]; other site 885275004551 Mg++ binding site [ion binding]; other site 885275004552 motif III; other site 885275004553 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 885275004554 nucleotide binding region [chemical binding]; other site 885275004555 ATP-binding site [chemical binding]; other site 885275004556 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 885275004557 putative RNA binding site [nucleotide binding]; other site 885275004558 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 885275004559 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 885275004560 Ligand Binding Site [chemical binding]; other site 885275004561 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 885275004562 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 885275004563 DNA binding site [nucleotide binding] 885275004564 active site 885275004565 Int/Topo IB signature motif; other site 885275004566 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 885275004567 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 885275004568 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 885275004569 Ligand Binding Site [chemical binding]; other site 885275004570 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 885275004571 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 885275004572 trimer interface [polypeptide binding]; other site 885275004573 eyelet of channel; other site 885275004574 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 885275004575 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 885275004576 dimer interface [polypeptide binding]; other site 885275004577 PYR/PP interface [polypeptide binding]; other site 885275004578 TPP binding site [chemical binding]; other site 885275004579 substrate binding site [chemical binding]; other site 885275004580 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 885275004581 Domain of unknown function; Region: EKR; smart00890 885275004582 4Fe-4S binding domain; Region: Fer4_6; pfam12837 885275004583 4Fe-4S binding domain; Region: Fer4; pfam00037 885275004584 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 885275004585 TPP-binding site [chemical binding]; other site 885275004586 dimer interface [polypeptide binding]; other site 885275004587 metabolite-proton symporter; Region: 2A0106; TIGR00883 885275004588 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 885275004589 Domain of unknown function (DUF333); Region: DUF333; pfam03891 885275004590 heat-inducible protein; Provisional; Region: PRK10449 885275004591 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 885275004592 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 885275004593 putative ligand binding site [chemical binding]; other site 885275004594 putative NAD binding site [chemical binding]; other site 885275004595 catalytic site [active] 885275004596 hypothetical protein; Provisional; Region: PRK10695 885275004597 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 885275004598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 885275004599 Autotransporter beta-domain; Region: Autotransporter; pfam03797 885275004600 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 885275004601 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 885275004602 active site 885275004603 catalytic tetrad [active] 885275004604 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 885275004605 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 885275004606 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 885275004607 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 885275004608 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 885275004609 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275004610 S-adenosylmethionine binding site [chemical binding]; other site 885275004611 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 885275004612 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 885275004613 active site 885275004614 Dual specificity phosphatase, catalytic domain; Region: DSPc; smart00195 885275004615 active site 885275004616 catalytic residues [active] 885275004617 azoreductase; Reviewed; Region: PRK00170 885275004618 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 885275004619 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 885275004620 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 885275004621 ATP binding site [chemical binding]; other site 885275004622 putative Mg++ binding site [ion binding]; other site 885275004623 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 885275004624 nucleotide binding region [chemical binding]; other site 885275004625 ATP-binding site [chemical binding]; other site 885275004626 Helicase associated domain (HA2); Region: HA2; pfam04408 885275004627 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 885275004628 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 885275004629 Uncharacterized conserved protein [Function unknown]; Region: COG1434 885275004630 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 885275004631 putative active site [active] 885275004632 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 885275004633 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 885275004634 NAD binding site [chemical binding]; other site 885275004635 catalytic residues [active] 885275004636 substrate binding site [chemical binding]; other site 885275004637 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 885275004638 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 885275004639 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 885275004640 cytochrome b561; Provisional; Region: PRK11513 885275004641 hypothetical protein; Provisional; Region: PRK10040 885275004642 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 885275004643 dimer interface [polypeptide binding]; other site 885275004644 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 885275004645 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275004646 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 885275004647 dimerization interface [polypeptide binding]; other site 885275004648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 885275004649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 885275004650 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 885275004651 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 885275004652 hypothetical protein; Provisional; Region: PRK11415 885275004653 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 885275004654 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 885275004655 Coenzyme A binding pocket [chemical binding]; other site 885275004656 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 885275004657 putative trimer interface [polypeptide binding]; other site 885275004658 putative CoA binding site [chemical binding]; other site 885275004659 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 885275004660 putative trimer interface [polypeptide binding]; other site 885275004661 putative CoA binding site [chemical binding]; other site 885275004662 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 885275004663 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 885275004664 gating phenylalanine in ion channel; other site 885275004665 tellurite resistance protein TehB; Provisional; Region: PRK11207 885275004666 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275004667 S-adenosylmethionine binding site [chemical binding]; other site 885275004668 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 885275004669 benzoate transporter; Region: benE; TIGR00843 885275004670 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 885275004671 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 885275004672 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 885275004673 non-specific DNA binding site [nucleotide binding]; other site 885275004674 salt bridge; other site 885275004675 sequence-specific DNA binding site [nucleotide binding]; other site 885275004676 Cupin domain; Region: Cupin_2; pfam07883 885275004677 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 885275004678 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 885275004679 Peptidase family U32; Region: Peptidase_U32; pfam01136 885275004680 Collagenase; Region: DUF3656; pfam12392 885275004681 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 885275004682 Helix-turn-helix; Region: HTH_3; pfam01381 885275004683 sequence-specific DNA binding site [nucleotide binding]; other site 885275004684 salt bridge; other site 885275004685 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 885275004686 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885275004687 DNA-binding site [nucleotide binding]; DNA binding site 885275004688 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 885275004689 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275004690 homodimer interface [polypeptide binding]; other site 885275004691 catalytic residue [active] 885275004692 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 885275004693 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 885275004694 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 885275004695 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885275004696 Walker A/P-loop; other site 885275004697 ATP binding site [chemical binding]; other site 885275004698 Q-loop/lid; other site 885275004699 ABC transporter signature motif; other site 885275004700 Walker B; other site 885275004701 D-loop; other site 885275004702 H-loop/switch region; other site 885275004703 TOBE domain; Region: TOBE_2; pfam08402 885275004704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275004705 dimer interface [polypeptide binding]; other site 885275004706 conserved gate region; other site 885275004707 putative PBP binding loops; other site 885275004708 ABC-ATPase subunit interface; other site 885275004709 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 885275004710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275004711 ABC-ATPase subunit interface; other site 885275004712 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 885275004713 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 885275004714 tetrameric interface [polypeptide binding]; other site 885275004715 NAD binding site [chemical binding]; other site 885275004716 catalytic residues [active] 885275004717 substrate binding site [chemical binding]; other site 885275004718 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 885275004719 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 885275004720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 885275004721 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 885275004722 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 885275004723 Coenzyme A binding pocket [chemical binding]; other site 885275004724 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 885275004725 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 885275004726 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885275004727 N-terminal plug; other site 885275004728 ligand-binding site [chemical binding]; other site 885275004729 PQQ-like domain; Region: PQQ_2; pfam13360 885275004730 L-asparagine permease; Provisional; Region: PRK15049 885275004731 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 885275004732 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 885275004733 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 885275004734 dimer interface [polypeptide binding]; other site 885275004735 substrate binding pocket (H-site) [chemical binding]; other site 885275004736 N-terminal domain interface [polypeptide binding]; other site 885275004737 PAAR motif; Region: PAAR_motif; pfam05488 885275004738 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 885275004739 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 885275004740 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 885275004741 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 885275004742 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 885275004743 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 885275004744 PAAR motif; Region: PAAR_motif; pfam05488 885275004745 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 885275004746 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 885275004747 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 885275004748 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 885275004749 Peptidase M35-like domain of uncharacterized proteins; Region: M35_like_1; cd11007 885275004750 putative active site [active] 885275004751 putative Zn binding site [ion binding]; other site 885275004752 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 885275004753 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 885275004754 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 885275004755 hypothetical protein; Provisional; Region: PRK10281 885275004756 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 885275004757 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 885275004758 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 885275004759 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 885275004760 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 885275004761 [4Fe-4S] binding site [ion binding]; other site 885275004762 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 885275004763 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 885275004764 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 885275004765 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 885275004766 molybdopterin cofactor binding site; other site 885275004767 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 885275004768 aromatic amino acid exporter; Provisional; Region: PRK11689 885275004769 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 885275004770 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 885275004771 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 885275004772 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 885275004773 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 885275004774 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 885275004775 non-specific DNA binding site [nucleotide binding]; other site 885275004776 salt bridge; other site 885275004777 sequence-specific DNA binding site [nucleotide binding]; other site 885275004778 Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015 885275004779 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 885275004780 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 885275004781 NAD binding site [chemical binding]; other site 885275004782 substrate binding site [chemical binding]; other site 885275004783 catalytic Zn binding site [ion binding]; other site 885275004784 tetramer interface [polypeptide binding]; other site 885275004785 structural Zn binding site [ion binding]; other site 885275004786 malate dehydrogenase; Provisional; Region: PRK13529 885275004787 Malic enzyme, N-terminal domain; Region: malic; pfam00390 885275004788 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 885275004789 NAD(P) binding site [chemical binding]; other site 885275004790 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 885275004791 Putative biofilm-dependent modulation protein; Region: BDM; pfam10684 885275004792 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 885275004793 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 885275004794 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 885275004795 putative active site [active] 885275004796 heme pocket [chemical binding]; other site 885275004797 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 885275004798 putative active site [active] 885275004799 heme pocket [chemical binding]; other site 885275004800 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885275004801 metal binding site [ion binding]; metal-binding site 885275004802 active site 885275004803 I-site; other site 885275004804 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885275004805 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 885275004806 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885275004807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 885275004808 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 885275004809 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 885275004810 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 885275004811 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275004812 catalytic residue [active] 885275004813 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 885275004814 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 885275004815 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 885275004816 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 885275004817 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 885275004818 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 885275004819 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 885275004820 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 885275004821 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 885275004822 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 885275004823 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 885275004824 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885275004825 FeS/SAM binding site; other site 885275004826 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 885275004827 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 885275004828 Sulfatase; Region: Sulfatase; pfam00884 885275004829 transcriptional regulator YdeO; Provisional; Region: PRK09940 885275004830 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275004831 putative oxidoreductase; Provisional; Region: PRK09939 885275004832 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 885275004833 putative molybdopterin cofactor binding site [chemical binding]; other site 885275004834 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 885275004835 putative molybdopterin cofactor binding site; other site 885275004836 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 885275004837 mannosyl binding site [chemical binding]; other site 885275004838 Fimbrial protein; Region: Fimbrial; pfam00419 885275004839 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 885275004840 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 885275004841 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 885275004842 PapC N-terminal domain; Region: PapC_N; pfam13954 885275004843 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 885275004844 PapC C-terminal domain; Region: PapC_C; pfam13953 885275004845 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 885275004846 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 885275004847 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 885275004848 Fimbrial protein; Region: Fimbrial; cl01416 885275004849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 885275004850 HipA N-terminal domain; Region: Couple_hipA; pfam13657 885275004851 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 885275004852 HipA-like N-terminal domain; Region: HipA_N; pfam07805 885275004853 HipA-like C-terminal domain; Region: HipA_C; pfam07804 885275004854 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 885275004855 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 885275004856 non-specific DNA binding site [nucleotide binding]; other site 885275004857 salt bridge; other site 885275004858 sequence-specific DNA binding site [nucleotide binding]; other site 885275004859 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 885275004860 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275004861 S-adenosylmethionine binding site [chemical binding]; other site 885275004862 Predicted membrane protein [Function unknown]; Region: COG3781 885275004863 altronate oxidoreductase; Provisional; Region: PRK03643 885275004864 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 885275004865 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 885275004866 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 885275004867 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885275004868 metal binding site [ion binding]; metal-binding site 885275004869 active site 885275004870 I-site; other site 885275004871 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 885275004872 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 885275004873 glutaminase; Provisional; Region: PRK00971 885275004874 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 885275004875 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 885275004876 NAD(P) binding site [chemical binding]; other site 885275004877 catalytic residues [active] 885275004878 Transcriptional regulator [Transcription]; Region: LysR; COG0583 885275004879 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275004880 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 885275004881 putative dimerization interface [polypeptide binding]; other site 885275004882 putative arabinose transporter; Provisional; Region: PRK03545 885275004883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275004884 putative substrate translocation pore; other site 885275004885 inner membrane protein; Provisional; Region: PRK10995 885275004886 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 885275004887 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 885275004888 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 885275004889 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275004890 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275004891 hypothetical protein; Provisional; Region: PRK10106 885275004892 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 885275004893 beta-galactosidase; Region: BGL; TIGR03356 885275004894 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 885275004895 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 885275004896 trimer interface; other site 885275004897 sugar binding site [chemical binding]; other site 885275004898 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 885275004899 active site 885275004900 methionine cluster; other site 885275004901 phosphorylation site [posttranslational modification] 885275004902 metal binding site [ion binding]; metal-binding site 885275004903 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 885275004904 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 885275004905 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 885275004906 active site 885275004907 P-loop; other site 885275004908 phosphorylation site [posttranslational modification] 885275004909 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 885275004910 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885275004911 DNA-binding site [nucleotide binding]; DNA binding site 885275004912 UTRA domain; Region: UTRA; pfam07702 885275004913 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 885275004914 EamA-like transporter family; Region: EamA; pfam00892 885275004915 EamA-like transporter family; Region: EamA; pfam00892 885275004916 putative transporter; Provisional; Region: PRK10054 885275004917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275004918 putative substrate translocation pore; other site 885275004919 diguanylate cyclase; Provisional; Region: PRK09894 885275004920 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 885275004921 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885275004922 metal binding site [ion binding]; metal-binding site 885275004923 active site 885275004924 I-site; other site 885275004925 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 885275004926 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 885275004927 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 885275004928 active site 885275004929 Zn binding site [ion binding]; other site 885275004930 malonic semialdehyde reductase; Provisional; Region: PRK10538 885275004931 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 885275004932 putative NAD(P) binding site [chemical binding]; other site 885275004933 homodimer interface [polypeptide binding]; other site 885275004934 homotetramer interface [polypeptide binding]; other site 885275004935 active site 885275004936 Transcriptional regulators [Transcription]; Region: GntR; COG1802 885275004937 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885275004938 DNA-binding site [nucleotide binding]; DNA binding site 885275004939 FCD domain; Region: FCD; pfam07729 885275004940 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 885275004941 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 885275004942 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 885275004943 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 885275004944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275004945 metabolite-proton symporter; Region: 2A0106; TIGR00883 885275004946 putative substrate translocation pore; other site 885275004947 putative oxidoreductase; Provisional; Region: PRK10083 885275004948 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 885275004949 putative NAD(P) binding site [chemical binding]; other site 885275004950 catalytic Zn binding site [ion binding]; other site 885275004951 structural Zn binding site [ion binding]; other site 885275004952 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 885275004953 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 885275004954 putative active site pocket [active] 885275004955 putative metal binding site [ion binding]; other site 885275004956 hypothetical protein; Provisional; Region: PRK02237 885275004957 hypothetical protein; Provisional; Region: PRK13659 885275004958 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 885275004959 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 885275004960 Coenzyme A binding pocket [chemical binding]; other site 885275004961 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 885275004962 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 885275004963 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 885275004964 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 885275004965 putative [Fe4-S4] binding site [ion binding]; other site 885275004966 putative molybdopterin cofactor binding site [chemical binding]; other site 885275004967 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 885275004968 putative molybdopterin cofactor binding site; other site 885275004969 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 885275004970 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 885275004971 putative [Fe4-S4] binding site [ion binding]; other site 885275004972 putative molybdopterin cofactor binding site [chemical binding]; other site 885275004973 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 885275004974 putative molybdopterin cofactor binding site; other site 885275004975 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 885275004976 4Fe-4S binding domain; Region: Fer4; cl02805 885275004977 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 885275004978 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 885275004979 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 885275004980 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 885275004981 Cl- selectivity filter; other site 885275004982 Cl- binding residues [ion binding]; other site 885275004983 pore gating glutamate residue; other site 885275004984 dimer interface [polypeptide binding]; other site 885275004985 putative dithiobiotin synthetase; Provisional; Region: PRK12374 885275004986 AAA domain; Region: AAA_26; pfam13500 885275004987 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 885275004988 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 885275004989 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 885275004990 nucleotide binding site [chemical binding]; other site 885275004991 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 885275004992 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275004993 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 885275004994 dimerization interface [polypeptide binding]; other site 885275004995 substrate binding pocket [chemical binding]; other site 885275004996 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 885275004997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275004998 putative substrate translocation pore; other site 885275004999 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 885275005000 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 885275005001 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 885275005002 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 885275005003 Domain of unknown function DUF20; Region: UPF0118; pfam01594 885275005004 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 885275005005 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 885275005006 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 885275005007 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 885275005008 ligand binding site [chemical binding]; other site 885275005009 homodimer interface [polypeptide binding]; other site 885275005010 NAD(P) binding site [chemical binding]; other site 885275005011 trimer interface B [polypeptide binding]; other site 885275005012 trimer interface A [polypeptide binding]; other site 885275005013 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 885275005014 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 885275005015 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 885275005016 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 885275005017 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 885275005018 Spore germination protein; Region: Spore_permease; cl17796 885275005019 dihydromonapterin reductase; Provisional; Region: PRK06483 885275005020 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 885275005021 NADP binding site [chemical binding]; other site 885275005022 substrate binding pocket [chemical binding]; other site 885275005023 active site 885275005024 GlpM protein; Region: GlpM; pfam06942 885275005025 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 885275005026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275005027 active site 885275005028 phosphorylation site [posttranslational modification] 885275005029 intermolecular recognition site; other site 885275005030 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 885275005031 DNA binding site [nucleotide binding] 885275005032 sensor protein RstB; Provisional; Region: PRK10604 885275005033 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 885275005034 dimerization interface [polypeptide binding]; other site 885275005035 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885275005036 dimer interface [polypeptide binding]; other site 885275005037 phosphorylation site [posttranslational modification] 885275005038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275005039 ATP binding site [chemical binding]; other site 885275005040 Mg2+ binding site [ion binding]; other site 885275005041 G-X-G motif; other site 885275005042 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 885275005043 fumarate hydratase; Reviewed; Region: fumC; PRK00485 885275005044 Class II fumarases; Region: Fumarase_classII; cd01362 885275005045 active site 885275005046 tetramer interface [polypeptide binding]; other site 885275005047 fumarate hydratase; Provisional; Region: PRK15389 885275005048 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 885275005049 Fumarase C-terminus; Region: Fumerase_C; pfam05683 885275005050 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 885275005051 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 885275005052 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 885275005053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 885275005054 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 885275005055 putative outer membrane porin protein; Provisional; Region: PRK11379 885275005056 glucuronide transporter; Provisional; Region: PRK09848 885275005057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275005058 putative substrate translocation pore; other site 885275005059 beta-D-glucuronidase; Provisional; Region: PRK10150 885275005060 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 885275005061 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 885275005062 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 885275005063 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 885275005064 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 885275005065 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 885275005066 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 885275005067 NAD binding site [chemical binding]; other site 885275005068 substrate binding site [chemical binding]; other site 885275005069 homotetramer interface [polypeptide binding]; other site 885275005070 homodimer interface [polypeptide binding]; other site 885275005071 active site 885275005072 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 885275005073 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 885275005074 DNA binding site [nucleotide binding] 885275005075 domain linker motif; other site 885275005076 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 885275005077 putative dimerization interface [polypeptide binding]; other site 885275005078 putative ligand binding site [chemical binding]; other site 885275005079 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 885275005080 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 885275005081 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 885275005082 active site turn [active] 885275005083 phosphorylation site [posttranslational modification] 885275005084 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 885275005085 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 885275005086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275005087 homodimer interface [polypeptide binding]; other site 885275005088 catalytic residue [active] 885275005089 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 885275005090 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 885275005091 active site 885275005092 purine riboside binding site [chemical binding]; other site 885275005093 putative oxidoreductase; Provisional; Region: PRK11579 885275005094 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 885275005095 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 885275005096 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 885275005097 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 885275005098 electron transport complex protein RsxA; Provisional; Region: PRK05151 885275005099 electron transport complex protein RnfB; Provisional; Region: PRK05113 885275005100 Putative Fe-S cluster; Region: FeS; pfam04060 885275005101 4Fe-4S binding domain; Region: Fer4; pfam00037 885275005102 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 885275005103 SLBB domain; Region: SLBB; pfam10531 885275005104 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 885275005105 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 885275005106 electron transport complex protein RnfG; Validated; Region: PRK01908 885275005107 electron transport complex RsxE subunit; Provisional; Region: PRK12405 885275005108 endonuclease III; Provisional; Region: PRK10702 885275005109 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 885275005110 minor groove reading motif; other site 885275005111 helix-hairpin-helix signature motif; other site 885275005112 substrate binding pocket [chemical binding]; other site 885275005113 active site 885275005114 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 885275005115 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 885275005116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275005117 putative substrate translocation pore; other site 885275005118 POT family; Region: PTR2; pfam00854 885275005119 glutathionine S-transferase; Provisional; Region: PRK10542 885275005120 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 885275005121 C-terminal domain interface [polypeptide binding]; other site 885275005122 GSH binding site (G-site) [chemical binding]; other site 885275005123 dimer interface [polypeptide binding]; other site 885275005124 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 885275005125 N-terminal domain interface [polypeptide binding]; other site 885275005126 dimer interface [polypeptide binding]; other site 885275005127 substrate binding pocket (H-site) [chemical binding]; other site 885275005128 pyridoxamine kinase; Validated; Region: PRK05756 885275005129 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 885275005130 dimer interface [polypeptide binding]; other site 885275005131 pyridoxal binding site [chemical binding]; other site 885275005132 ATP binding site [chemical binding]; other site 885275005133 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 885275005134 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 885275005135 active site 885275005136 HIGH motif; other site 885275005137 dimer interface [polypeptide binding]; other site 885275005138 KMSKS motif; other site 885275005139 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 885275005140 RNA binding surface [nucleotide binding]; other site 885275005141 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 885275005142 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 885275005143 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 885275005144 lysozyme inhibitor; Provisional; Region: PRK11372 885275005145 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 885275005146 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 885275005147 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 885275005148 transcriptional regulator SlyA; Provisional; Region: PRK03573 885275005149 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 885275005150 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 885275005151 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 885275005152 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885275005153 HlyD family secretion protein; Region: HlyD_3; pfam13437 885275005154 Fusaric acid resistance protein family; Region: FUSC; pfam04632 885275005155 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 885275005156 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 885275005157 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 885275005158 E-class dimer interface [polypeptide binding]; other site 885275005159 P-class dimer interface [polypeptide binding]; other site 885275005160 active site 885275005161 Cu2+ binding site [ion binding]; other site 885275005162 Zn2+ binding site [ion binding]; other site 885275005163 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 885275005164 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 885275005165 active site 885275005166 catalytic tetrad [active] 885275005167 Predicted Fe-S protein [General function prediction only]; Region: COG3313 885275005168 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 885275005169 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 885275005170 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 885275005171 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 885275005172 FMN binding site [chemical binding]; other site 885275005173 active site 885275005174 substrate binding site [chemical binding]; other site 885275005175 catalytic residue [active] 885275005176 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 885275005177 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 885275005178 dimer interface [polypeptide binding]; other site 885275005179 active site 885275005180 metal binding site [ion binding]; metal-binding site 885275005181 glutathione binding site [chemical binding]; other site 885275005182 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 885275005183 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 885275005184 dimer interface [polypeptide binding]; other site 885275005185 catalytic site [active] 885275005186 putative active site [active] 885275005187 putative substrate binding site [chemical binding]; other site 885275005188 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 885275005189 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 885275005190 putative GSH binding site [chemical binding]; other site 885275005191 catalytic residues [active] 885275005192 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 885275005193 NlpC/P60 family; Region: NLPC_P60; pfam00877 885275005194 superoxide dismutase; Provisional; Region: PRK10543 885275005195 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 885275005196 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 885275005197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275005198 Major Facilitator Superfamily; Region: MFS_1; pfam07690 885275005199 putative substrate translocation pore; other site 885275005200 hypothetical protein; Provisional; Region: PRK14756 885275005201 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 885275005202 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 885275005203 DNA binding site [nucleotide binding] 885275005204 domain linker motif; other site 885275005205 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 885275005206 dimerization interface [polypeptide binding]; other site 885275005207 ligand binding site [chemical binding]; other site 885275005208 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 885275005209 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275005210 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 885275005211 dimerization interface [polypeptide binding]; other site 885275005212 putative transporter; Provisional; Region: PRK11043 885275005213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275005214 putative substrate translocation pore; other site 885275005215 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 885275005216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 885275005217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275005218 S-adenosylmethionine binding site [chemical binding]; other site 885275005219 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 885275005220 Lumazine binding domain; Region: Lum_binding; pfam00677 885275005221 Lumazine binding domain; Region: Lum_binding; pfam00677 885275005222 multidrug efflux protein; Reviewed; Region: PRK01766 885275005223 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 885275005224 cation binding site [ion binding]; other site 885275005225 hypothetical protein; Provisional; Region: PRK09945 885275005226 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 885275005227 putative monooxygenase; Provisional; Region: PRK11118 885275005228 hypothetical protein; Provisional; Region: PRK09897 885275005229 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 885275005230 hypothetical protein; Provisional; Region: PRK09946 885275005231 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 885275005232 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 885275005233 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 885275005234 hypothetical protein; Provisional; Region: PRK09947 885275005235 putative oxidoreductase; Provisional; Region: PRK09849 885275005236 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 885275005237 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 885275005238 hypothetical protein; Provisional; Region: PRK09898 885275005239 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 885275005240 hypothetical protein; Provisional; Region: PRK10292 885275005241 pyruvate kinase; Provisional; Region: PRK09206 885275005242 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 885275005243 active site 885275005244 domain interfaces; other site 885275005245 murein lipoprotein; Provisional; Region: PRK15396 885275005246 L,D-transpeptidase; Provisional; Region: PRK10190 885275005247 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 885275005248 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 885275005249 cysteine desufuration protein SufE; Provisional; Region: PRK09296 885275005250 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 885275005251 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 885275005252 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 885275005253 catalytic residue [active] 885275005254 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 885275005255 FeS assembly protein SufD; Region: sufD; TIGR01981 885275005256 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 885275005257 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 885275005258 Walker A/P-loop; other site 885275005259 ATP binding site [chemical binding]; other site 885275005260 Q-loop/lid; other site 885275005261 ABC transporter signature motif; other site 885275005262 Walker B; other site 885275005263 D-loop; other site 885275005264 H-loop/switch region; other site 885275005265 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 885275005266 putative ABC transporter; Region: ycf24; CHL00085 885275005267 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 885275005268 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 885275005269 CoenzymeA binding site [chemical binding]; other site 885275005270 subunit interaction site [polypeptide binding]; other site 885275005271 PHB binding site; other site 885275005272 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 885275005273 FAD binding domain; Region: FAD_binding_4; pfam01565 885275005274 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 885275005275 putative inner membrane protein; Provisional; Region: PRK10983 885275005276 Domain of unknown function DUF20; Region: UPF0118; pfam01594 885275005277 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 885275005278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275005279 Major Facilitator Superfamily; Region: MFS_1; pfam07690 885275005280 putative substrate translocation pore; other site 885275005281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275005282 putative substrate translocation pore; other site 885275005283 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 885275005284 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 885275005285 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 885275005286 shikimate binding site; other site 885275005287 NAD(P) binding site [chemical binding]; other site 885275005288 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 885275005289 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 885275005290 active site 885275005291 catalytic residue [active] 885275005292 dimer interface [polypeptide binding]; other site 885275005293 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 885275005294 Coenzyme A transferase; Region: CoA_trans; smart00882 885275005295 Coenzyme A transferase; Region: CoA_trans; cl17247 885275005296 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 885275005297 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 885275005298 active site 885275005299 Cupin domain; Region: Cupin_2; pfam07883 885275005300 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 885275005301 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 885275005302 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275005303 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 885275005304 Ligand binding site [chemical binding]; other site 885275005305 Electron transfer flavoprotein domain; Region: ETF; pfam01012 885275005306 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 885275005307 Electron transfer flavoprotein domain; Region: ETF; smart00893 885275005308 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 885275005309 oxidoreductase; Provisional; Region: PRK10015 885275005310 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 885275005311 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 885275005312 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 885275005313 acyl-activating enzyme (AAE) consensus motif; other site 885275005314 putative AMP binding site [chemical binding]; other site 885275005315 putative active site [active] 885275005316 putative CoA binding site [chemical binding]; other site 885275005317 phosphoenolpyruvate synthase; Validated; Region: PRK06464 885275005318 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 885275005319 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 885275005320 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 885275005321 PEP synthetase regulatory protein; Provisional; Region: PRK05339 885275005322 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 885275005323 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 885275005324 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 885275005325 Uncharacterized conserved protein [Function unknown]; Region: COG0397 885275005326 hypothetical protein; Validated; Region: PRK00029 885275005327 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 885275005328 NlpC/P60 family; Region: NLPC_P60; pfam00877 885275005329 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 885275005330 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 885275005331 Walker A/P-loop; other site 885275005332 ATP binding site [chemical binding]; other site 885275005333 Q-loop/lid; other site 885275005334 ABC transporter signature motif; other site 885275005335 Walker B; other site 885275005336 D-loop; other site 885275005337 H-loop/switch region; other site 885275005338 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 885275005339 catalytic residues [active] 885275005340 dimer interface [polypeptide binding]; other site 885275005341 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 885275005342 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 885275005343 ABC-ATPase subunit interface; other site 885275005344 dimer interface [polypeptide binding]; other site 885275005345 putative PBP binding regions; other site 885275005346 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 885275005347 IHF dimer interface [polypeptide binding]; other site 885275005348 IHF - DNA interface [nucleotide binding]; other site 885275005349 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 885275005350 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 885275005351 putative tRNA-binding site [nucleotide binding]; other site 885275005352 B3/4 domain; Region: B3_4; pfam03483 885275005353 tRNA synthetase B5 domain; Region: B5; smart00874 885275005354 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 885275005355 dimer interface [polypeptide binding]; other site 885275005356 motif 1; other site 885275005357 motif 3; other site 885275005358 motif 2; other site 885275005359 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 885275005360 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 885275005361 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 885275005362 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 885275005363 dimer interface [polypeptide binding]; other site 885275005364 motif 1; other site 885275005365 active site 885275005366 motif 2; other site 885275005367 motif 3; other site 885275005368 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 885275005369 23S rRNA binding site [nucleotide binding]; other site 885275005370 L21 binding site [polypeptide binding]; other site 885275005371 L13 binding site [polypeptide binding]; other site 885275005372 carbamoyl-phosphate synthase (glutamine-hydrolyzing); Region: PLN02771 885275005373 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 885275005374 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 885275005375 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 885275005376 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 885275005377 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 885275005378 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 885275005379 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 885275005380 active site 885275005381 dimer interface [polypeptide binding]; other site 885275005382 motif 1; other site 885275005383 motif 2; other site 885275005384 motif 3; other site 885275005385 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 885275005386 anticodon binding site; other site 885275005387 potential frameshift: common BLAST hit: gi|254793337|ref|YP_003078174.1| non-LEE-encoded type III effector 885275005388 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 885275005389 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 885275005390 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 885275005391 6-phosphofructokinase 2; Provisional; Region: PRK10294 885275005392 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 885275005393 putative substrate binding site [chemical binding]; other site 885275005394 putative ATP binding site [chemical binding]; other site 885275005395 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 885275005396 Phosphotransferase enzyme family; Region: APH; pfam01636 885275005397 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 885275005398 active site 885275005399 ATP binding site [chemical binding]; other site 885275005400 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 885275005401 YniB-like protein; Region: YniB; pfam14002 885275005402 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 885275005403 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 885275005404 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885275005405 motif II; other site 885275005406 inner membrane protein; Provisional; Region: PRK11648 885275005407 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 885275005408 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 885275005409 cell division modulator; Provisional; Region: PRK10113 885275005410 hydroperoxidase II; Provisional; Region: katE; PRK11249 885275005411 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 885275005412 tetramer interface [polypeptide binding]; other site 885275005413 heme binding pocket [chemical binding]; other site 885275005414 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 885275005415 domain interactions; other site 885275005416 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 885275005417 putative active site [active] 885275005418 YdjC motif; other site 885275005419 Mg binding site [ion binding]; other site 885275005420 putative homodimer interface [polypeptide binding]; other site 885275005421 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 885275005422 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 885275005423 NAD binding site [chemical binding]; other site 885275005424 sugar binding site [chemical binding]; other site 885275005425 divalent metal binding site [ion binding]; other site 885275005426 tetramer (dimer of dimers) interface [polypeptide binding]; other site 885275005427 dimer interface [polypeptide binding]; other site 885275005428 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 885275005429 Cupin domain; Region: Cupin_2; pfam07883 885275005430 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275005431 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 885275005432 methionine cluster; other site 885275005433 active site 885275005434 phosphorylation site [posttranslational modification] 885275005435 metal binding site [ion binding]; metal-binding site 885275005436 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 885275005437 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 885275005438 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 885275005439 active site 885275005440 P-loop; other site 885275005441 phosphorylation site [posttranslational modification] 885275005442 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 885275005443 NAD+ synthetase; Region: nadE; TIGR00552 885275005444 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 885275005445 homodimer interface [polypeptide binding]; other site 885275005446 NAD binding pocket [chemical binding]; other site 885275005447 ATP binding pocket [chemical binding]; other site 885275005448 Mg binding site [ion binding]; other site 885275005449 active-site loop [active] 885275005450 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 885275005451 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 885275005452 GIY-YIG motif/motif A; other site 885275005453 active site 885275005454 catalytic site [active] 885275005455 putative DNA binding site [nucleotide binding]; other site 885275005456 metal binding site [ion binding]; metal-binding site 885275005457 hypothetical protein; Provisional; Region: PRK11396 885275005458 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 885275005459 dimer interface [polypeptide binding]; other site 885275005460 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 885275005461 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 885275005462 putative active site [active] 885275005463 Zn binding site [ion binding]; other site 885275005464 succinylarginine dihydrolase; Provisional; Region: PRK13281 885275005465 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 885275005466 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 885275005467 NAD(P) binding site [chemical binding]; other site 885275005468 catalytic residues [active] 885275005469 arginine succinyltransferase; Provisional; Region: PRK10456 885275005470 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 885275005471 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 885275005472 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 885275005473 inhibitor-cofactor binding pocket; inhibition site 885275005474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275005475 catalytic residue [active] 885275005476 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 885275005477 putative catalytic site [active] 885275005478 putative phosphate binding site [ion binding]; other site 885275005479 active site 885275005480 metal binding site A [ion binding]; metal-binding site 885275005481 DNA binding site [nucleotide binding] 885275005482 putative AP binding site [nucleotide binding]; other site 885275005483 putative metal binding site B [ion binding]; other site 885275005484 Uncharacterized conserved protein [Function unknown]; Region: COG0398 885275005485 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 885275005486 Uncharacterized conserved protein [Function unknown]; Region: COG0398 885275005487 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 885275005488 Uncharacterized conserved protein [Function unknown]; Region: COG2128 885275005489 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 885275005490 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 885275005491 hypothetical protein; Provisional; Region: PRK11622 885275005492 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 885275005493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275005494 dimer interface [polypeptide binding]; other site 885275005495 conserved gate region; other site 885275005496 putative PBP binding loops; other site 885275005497 ABC-ATPase subunit interface; other site 885275005498 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 885275005499 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885275005500 Walker A/P-loop; other site 885275005501 ATP binding site [chemical binding]; other site 885275005502 Q-loop/lid; other site 885275005503 ABC transporter signature motif; other site 885275005504 Walker B; other site 885275005505 D-loop; other site 885275005506 H-loop/switch region; other site 885275005507 Rhodanese Homology Domain; Region: RHOD; smart00450 885275005508 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 885275005509 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 885275005510 active site residue [active] 885275005511 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 885275005512 active site residue [active] 885275005513 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 885275005514 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 885275005515 active site 885275005516 8-oxo-dGMP binding site [chemical binding]; other site 885275005517 nudix motif; other site 885275005518 metal binding site [ion binding]; metal-binding site 885275005519 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 885275005520 glutamate dehydrogenase; Provisional; Region: PRK09414 885275005521 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 885275005522 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 885275005523 NAD(P) binding site [chemical binding]; other site 885275005524 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 885275005525 HSP70 interaction site [polypeptide binding]; other site 885275005526 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 885275005527 Sel1-like repeats; Region: SEL1; smart00671 885275005528 Sel1-like repeats; Region: SEL1; smart00671 885275005529 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 885275005530 Sel1-like repeats; Region: SEL1; smart00671 885275005531 Sel1-like repeats; Region: SEL1; smart00671 885275005532 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 885275005533 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 885275005534 nucleotide binding site [chemical binding]; other site 885275005535 putative NEF/HSP70 interaction site [polypeptide binding]; other site 885275005536 SBD interface [polypeptide binding]; other site 885275005537 DNA topoisomerase III; Provisional; Region: PRK07726 885275005538 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 885275005539 active site 885275005540 putative interdomain interaction site [polypeptide binding]; other site 885275005541 putative metal-binding site [ion binding]; other site 885275005542 putative nucleotide binding site [chemical binding]; other site 885275005543 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 885275005544 domain I; other site 885275005545 DNA binding groove [nucleotide binding] 885275005546 phosphate binding site [ion binding]; other site 885275005547 domain II; other site 885275005548 domain III; other site 885275005549 nucleotide binding site [chemical binding]; other site 885275005550 catalytic site [active] 885275005551 domain IV; other site 885275005552 selenophosphate synthetase; Provisional; Region: PRK00943 885275005553 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 885275005554 dimerization interface [polypeptide binding]; other site 885275005555 putative ATP binding site [chemical binding]; other site 885275005556 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 885275005557 putative FMN binding site [chemical binding]; other site 885275005558 protease 4; Provisional; Region: PRK10949 885275005559 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 885275005560 tandem repeat interface [polypeptide binding]; other site 885275005561 oligomer interface [polypeptide binding]; other site 885275005562 active site residues [active] 885275005563 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 885275005564 tandem repeat interface [polypeptide binding]; other site 885275005565 oligomer interface [polypeptide binding]; other site 885275005566 active site residues [active] 885275005567 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 885275005568 active site 885275005569 homodimer interface [polypeptide binding]; other site 885275005570 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 885275005571 Isochorismatase family; Region: Isochorismatase; pfam00857 885275005572 catalytic triad [active] 885275005573 metal binding site [ion binding]; metal-binding site 885275005574 conserved cis-peptide bond; other site 885275005575 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 885275005576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275005577 putative substrate translocation pore; other site 885275005578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275005579 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 885275005580 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 885275005581 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 885275005582 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 885275005583 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 885275005584 active site 885275005585 catalytic tetrad [active] 885275005586 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 885275005587 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 885275005588 substrate binding site [chemical binding]; other site 885275005589 ATP binding site [chemical binding]; other site 885275005590 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 885275005591 intersubunit interface [polypeptide binding]; other site 885275005592 active site 885275005593 zinc binding site [ion binding]; other site 885275005594 Na+ binding site [ion binding]; other site 885275005595 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 885275005596 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 885275005597 inhibitor binding site; inhibition site 885275005598 catalytic Zn binding site [ion binding]; other site 885275005599 structural Zn binding site [ion binding]; other site 885275005600 NADP binding site [chemical binding]; other site 885275005601 tetramer interface [polypeptide binding]; other site 885275005602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275005603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275005604 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 885275005605 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 885275005606 putative NAD(P) binding site [chemical binding]; other site 885275005607 catalytic Zn binding site [ion binding]; other site 885275005608 structural Zn binding site [ion binding]; other site 885275005609 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 885275005610 methionine sulfoxide reductase B; Provisional; Region: PRK00222 885275005611 SelR domain; Region: SelR; pfam01641 885275005612 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 885275005613 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 885275005614 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 885275005615 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 885275005616 active site 885275005617 phosphate binding residues; other site 885275005618 catalytic residues [active] 885275005619 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 885275005620 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 885275005621 active site 885275005622 catalytic tetrad [active] 885275005623 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 885275005624 PrkA family serine protein kinase; Provisional; Region: PRK15455 885275005625 AAA ATPase domain; Region: AAA_16; pfam13191 885275005626 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 885275005627 hypothetical protein; Provisional; Region: PRK05325 885275005628 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 885275005629 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885275005630 metal binding site [ion binding]; metal-binding site 885275005631 active site 885275005632 I-site; other site 885275005633 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 885275005634 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885275005635 metal binding site [ion binding]; metal-binding site 885275005636 active site 885275005637 I-site; other site 885275005638 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 885275005639 putative deacylase active site [active] 885275005640 Predicted membrane protein [Function unknown]; Region: COG2707 885275005641 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 885275005642 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275005643 cyanate transporter; Region: CynX; TIGR00896 885275005644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275005645 Uncharacterized conserved protein [Function unknown]; Region: COG3189 885275005646 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 885275005647 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 885275005648 Domain of unknown function (DUF333); Region: DUF333; pfam03891 885275005649 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 885275005650 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 885275005651 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 885275005652 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885275005653 metal binding site [ion binding]; metal-binding site 885275005654 active site 885275005655 I-site; other site 885275005656 hypothetical protein; Provisional; Region: PRK10457 885275005657 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 885275005658 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 885275005659 leucine export protein LeuE; Provisional; Region: PRK10958 885275005660 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 885275005661 ribonuclease D; Provisional; Region: PRK10829 885275005662 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 885275005663 catalytic site [active] 885275005664 putative active site [active] 885275005665 putative substrate binding site [chemical binding]; other site 885275005666 Helicase and RNase D C-terminal; Region: HRDC; smart00341 885275005667 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 885275005668 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 885275005669 acyl-activating enzyme (AAE) consensus motif; other site 885275005670 putative AMP binding site [chemical binding]; other site 885275005671 putative active site [active] 885275005672 putative CoA binding site [chemical binding]; other site 885275005673 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 885275005674 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 885275005675 Glycoprotease family; Region: Peptidase_M22; pfam00814 885275005676 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 885275005677 DEAD/DEAH box helicase; Region: DEAD; pfam00270 885275005678 DEAD_2; Region: DEAD_2; pfam06733 885275005679 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 885275005680 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 885275005681 homotrimer interaction site [polypeptide binding]; other site 885275005682 putative active site [active] 885275005683 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 885275005684 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 885275005685 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 885275005686 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 885275005687 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 885275005688 putative active site [active] 885275005689 putative CoA binding site [chemical binding]; other site 885275005690 nudix motif; other site 885275005691 metal binding site [ion binding]; metal-binding site 885275005692 L-serine deaminase; Provisional; Region: PRK15023 885275005693 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 885275005694 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 885275005695 phage resistance protein; Provisional; Region: PRK10551 885275005696 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 885275005697 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885275005698 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 885275005699 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 885275005700 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 885275005701 Transporter associated domain; Region: CorC_HlyC; smart01091 885275005702 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 885275005703 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 885275005704 active pocket/dimerization site; other site 885275005705 active site 885275005706 phosphorylation site [posttranslational modification] 885275005707 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 885275005708 active site 885275005709 phosphorylation site [posttranslational modification] 885275005710 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 885275005711 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 885275005712 Predicted membrane protein [Function unknown]; Region: COG4811 885275005713 hypothetical protein; Provisional; Region: PRK11469 885275005714 Domain of unknown function DUF; Region: DUF204; pfam02659 885275005715 Domain of unknown function DUF; Region: DUF204; pfam02659 885275005716 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 885275005717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275005718 S-adenosylmethionine binding site [chemical binding]; other site 885275005719 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 885275005720 DNA-binding site [nucleotide binding]; DNA binding site 885275005721 RNA-binding motif; other site 885275005722 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 885275005723 YebO-like protein; Region: YebO; pfam13974 885275005724 PhoPQ regulatory protein; Provisional; Region: PRK10299 885275005725 YobH-like protein; Region: YobH; pfam13996 885275005726 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 885275005727 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 885275005728 dimerization interface [polypeptide binding]; other site 885275005729 putative Zn2+ binding site [ion binding]; other site 885275005730 putative DNA binding site [nucleotide binding]; other site 885275005731 Bacterial transcriptional regulator; Region: IclR; pfam01614 885275005732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275005733 Major Facilitator Superfamily; Region: MFS_1; pfam07690 885275005734 putative substrate translocation pore; other site 885275005735 Predicted integral membrane protein [Function unknown]; Region: COG5521 885275005736 heat shock protein HtpX; Provisional; Region: PRK05457 885275005737 carboxy-terminal protease; Provisional; Region: PRK11186 885275005738 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 885275005739 protein binding site [polypeptide binding]; other site 885275005740 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 885275005741 Catalytic dyad [active] 885275005742 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 885275005743 ProP expression regulator; Provisional; Region: PRK04950 885275005744 ProQ/FINO family; Region: ProQ; pfam04352 885275005745 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 885275005746 GAF domain; Region: GAF_2; pfam13185 885275005747 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 885275005748 Paraquat-inducible protein A; Region: PqiA; pfam04403 885275005749 Paraquat-inducible protein A; Region: PqiA; pfam04403 885275005750 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 885275005751 mce related protein; Region: MCE; pfam02470 885275005752 mce related protein; Region: MCE; pfam02470 885275005753 mce related protein; Region: MCE; pfam02470 885275005754 mce related protein; Region: MCE; pfam02470 885275005755 mce related protein; Region: MCE; pfam02470 885275005756 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 885275005757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275005758 S-adenosylmethionine binding site [chemical binding]; other site 885275005759 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 885275005760 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 885275005761 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 885275005762 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 885275005763 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 885275005764 active site 885275005765 metal binding site [ion binding]; metal-binding site 885275005766 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 885275005767 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 885275005768 hypothetical protein; Provisional; Region: PRK10301 885275005769 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 885275005770 Predicted amidohydrolase [General function prediction only]; Region: COG0388 885275005771 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 885275005772 exodeoxyribonuclease X; Provisional; Region: PRK07983 885275005773 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 885275005774 active site 885275005775 catalytic site [active] 885275005776 substrate binding site [chemical binding]; other site 885275005777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 885275005778 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 885275005779 putative metal binding site [ion binding]; other site 885275005780 hypothetical protein; Provisional; Region: PRK13680 885275005781 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 885275005782 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 885275005783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 885275005784 ATP-grasp domain; Region: ATP-grasp; pfam02222 885275005785 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 885275005786 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 885275005787 active site 885275005788 intersubunit interface [polypeptide binding]; other site 885275005789 catalytic residue [active] 885275005790 phosphogluconate dehydratase; Validated; Region: PRK09054 885275005791 6-phosphogluconate dehydratase; Region: edd; TIGR01196 885275005792 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 885275005793 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 885275005794 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 885275005795 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 885275005796 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 885275005797 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 885275005798 putative active site [active] 885275005799 pyruvate kinase; Provisional; Region: PRK05826 885275005800 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 885275005801 domain interfaces; other site 885275005802 active site 885275005803 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 885275005804 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 885275005805 putative acyl-acceptor binding pocket; other site 885275005806 putative peptidase; Provisional; Region: PRK11649 885275005807 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 885275005808 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 885275005809 Peptidase family M23; Region: Peptidase_M23; pfam01551 885275005810 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 885275005811 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 885275005812 metal binding site [ion binding]; metal-binding site 885275005813 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 885275005814 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 885275005815 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 885275005816 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 885275005817 ABC-ATPase subunit interface; other site 885275005818 dimer interface [polypeptide binding]; other site 885275005819 putative PBP binding regions; other site 885275005820 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 885275005821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275005822 Walker A motif; other site 885275005823 ATP binding site [chemical binding]; other site 885275005824 Walker B motif; other site 885275005825 arginine finger; other site 885275005826 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 885275005827 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 885275005828 RuvA N terminal domain; Region: RuvA_N; pfam01330 885275005829 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 885275005830 hypothetical protein; Provisional; Region: PRK11470 885275005831 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 885275005832 active site 885275005833 putative DNA-binding cleft [nucleotide binding]; other site 885275005834 dimer interface [polypeptide binding]; other site 885275005835 hypothetical protein; Validated; Region: PRK00110 885275005836 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 885275005837 nudix motif; other site 885275005838 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 885275005839 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 885275005840 dimer interface [polypeptide binding]; other site 885275005841 anticodon binding site; other site 885275005842 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 885275005843 homodimer interface [polypeptide binding]; other site 885275005844 motif 1; other site 885275005845 active site 885275005846 motif 2; other site 885275005847 GAD domain; Region: GAD; pfam02938 885275005848 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 885275005849 motif 3; other site 885275005850 Isochorismatase family; Region: Isochorismatase; pfam00857 885275005851 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 885275005852 catalytic triad [active] 885275005853 conserved cis-peptide bond; other site 885275005854 hypothetical protein; Provisional; Region: PRK10302 885275005855 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 885275005856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275005857 S-adenosylmethionine binding site [chemical binding]; other site 885275005858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275005859 S-adenosylmethionine binding site [chemical binding]; other site 885275005860 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 885275005861 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 885275005862 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 885275005863 molybdopterin cofactor binding site [chemical binding]; other site 885275005864 substrate binding site [chemical binding]; other site 885275005865 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 885275005866 molybdopterin cofactor binding site; other site 885275005867 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 885275005868 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 885275005869 copper homeostasis protein CutC; Provisional; Region: PRK11572 885275005870 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 885275005871 putative metal binding site [ion binding]; other site 885275005872 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 885275005873 arginyl-tRNA synthetase; Region: argS; TIGR00456 885275005874 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 885275005875 active site 885275005876 HIGH motif; other site 885275005877 KMSK motif region; other site 885275005878 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 885275005879 tRNA binding surface [nucleotide binding]; other site 885275005880 anticodon binding site; other site 885275005881 Flagellar protein FlhE; Region: FlhE; pfam06366 885275005882 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 885275005883 FHIPEP family; Region: FHIPEP; pfam00771 885275005884 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 885275005885 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 885275005886 chemotaxis regulator CheZ; Provisional; Region: PRK11166 885275005887 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 885275005888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275005889 active site 885275005890 phosphorylation site [posttranslational modification] 885275005891 intermolecular recognition site; other site 885275005892 dimerization interface [polypeptide binding]; other site 885275005893 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 885275005894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275005895 active site 885275005896 phosphorylation site [posttranslational modification] 885275005897 intermolecular recognition site; other site 885275005898 dimerization interface [polypeptide binding]; other site 885275005899 CheB methylesterase; Region: CheB_methylest; pfam01339 885275005900 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 885275005901 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 885275005902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275005903 S-adenosylmethionine binding site [chemical binding]; other site 885275005904 potential frameshift: common BLAST hit: gi|383177867|ref|YP_005455872.1| methyl-accepting protein IV 885275005905 methyl-accepting protein IV; Provisional; Region: PRK09793 885275005906 methyl-accepting protein IV; Provisional; Region: PRK09793 885275005907 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 885275005908 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 885275005909 dimer interface [polypeptide binding]; other site 885275005910 ligand binding site [chemical binding]; other site 885275005911 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 885275005912 dimerization interface [polypeptide binding]; other site 885275005913 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 885275005914 dimer interface [polypeptide binding]; other site 885275005915 putative CheW interface [polypeptide binding]; other site 885275005916 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 885275005917 putative CheA interaction surface; other site 885275005918 chemotaxis protein CheA; Provisional; Region: PRK10547 885275005919 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 885275005920 putative binding surface; other site 885275005921 active site 885275005922 CheY binding; Region: CheY-binding; pfam09078 885275005923 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 885275005924 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275005925 ATP binding site [chemical binding]; other site 885275005926 Mg2+ binding site [ion binding]; other site 885275005927 G-X-G motif; other site 885275005928 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 885275005929 flagellar motor protein MotB; Validated; Region: motB; PRK09041 885275005930 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 885275005931 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 885275005932 ligand binding site [chemical binding]; other site 885275005933 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 885275005934 flagellar motor protein MotA; Validated; Region: PRK09110 885275005935 transcriptional activator FlhC; Provisional; Region: PRK12722 885275005936 transcriptional activator FlhD; Provisional; Region: PRK02909 885275005937 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 885275005938 Ligand Binding Site [chemical binding]; other site 885275005939 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 885275005940 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 885275005941 active site 885275005942 homotetramer interface [polypeptide binding]; other site 885275005943 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 885275005944 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 885275005945 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 885275005946 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 885275005947 TM-ABC transporter signature motif; other site 885275005948 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 885275005949 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 885275005950 Walker A/P-loop; other site 885275005951 ATP binding site [chemical binding]; other site 885275005952 Q-loop/lid; other site 885275005953 ABC transporter signature motif; other site 885275005954 Walker B; other site 885275005955 D-loop; other site 885275005956 H-loop/switch region; other site 885275005957 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 885275005958 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 885275005959 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 885275005960 ligand binding site [chemical binding]; other site 885275005961 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 885275005962 Ferritin-like domain; Region: Ferritin; pfam00210 885275005963 ferroxidase diiron center [ion binding]; other site 885275005964 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 885275005965 YecR-like lipoprotein; Region: YecR; pfam13992 885275005966 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 885275005967 Ferritin-like domain; Region: Ferritin; pfam00210 885275005968 ferroxidase diiron center [ion binding]; other site 885275005969 probable metal-binding protein; Region: matur_matur; TIGR03853 885275005970 tyrosine transporter TyrP; Provisional; Region: PRK15132 885275005971 aromatic amino acid transport protein; Region: araaP; TIGR00837 885275005972 hypothetical protein; Provisional; Region: PRK10396 885275005973 yecA family protein; Region: ygfB_yecA; TIGR02292 885275005974 SEC-C motif; Region: SEC-C; pfam02810 885275005975 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 885275005976 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 885275005977 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 885275005978 GIY-YIG motif/motif A; other site 885275005979 active site 885275005980 catalytic site [active] 885275005981 putative DNA binding site [nucleotide binding]; other site 885275005982 metal binding site [ion binding]; metal-binding site 885275005983 UvrB/uvrC motif; Region: UVR; pfam02151 885275005984 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 885275005985 Helix-hairpin-helix motif; Region: HHH; pfam00633 885275005986 response regulator; Provisional; Region: PRK09483 885275005987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275005988 active site 885275005989 phosphorylation site [posttranslational modification] 885275005990 intermolecular recognition site; other site 885275005991 dimerization interface [polypeptide binding]; other site 885275005992 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885275005993 DNA binding residues [nucleotide binding] 885275005994 dimerization interface [polypeptide binding]; other site 885275005995 hypothetical protein; Provisional; Region: PRK10613 885275005996 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 885275005997 Autoinducer binding domain; Region: Autoind_bind; pfam03472 885275005998 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885275005999 DNA binding residues [nucleotide binding] 885275006000 dimerization interface [polypeptide binding]; other site 885275006001 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 885275006002 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 885275006003 Walker A/P-loop; other site 885275006004 ATP binding site [chemical binding]; other site 885275006005 Q-loop/lid; other site 885275006006 ABC transporter signature motif; other site 885275006007 Walker B; other site 885275006008 D-loop; other site 885275006009 H-loop/switch region; other site 885275006010 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 885275006011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275006012 dimer interface [polypeptide binding]; other site 885275006013 conserved gate region; other site 885275006014 putative PBP binding loops; other site 885275006015 ABC-ATPase subunit interface; other site 885275006016 D-cysteine desulfhydrase; Validated; Region: PRK03910 885275006017 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 885275006018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275006019 catalytic residue [active] 885275006020 cystine transporter subunit; Provisional; Region: PRK11260 885275006021 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 885275006022 substrate binding pocket [chemical binding]; other site 885275006023 membrane-bound complex binding site; other site 885275006024 hinge residues; other site 885275006025 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 885275006026 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 885275006027 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 885275006028 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 885275006029 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 885275006030 DNA binding residues [nucleotide binding] 885275006031 flagellin; Validated; Region: PRK08026 885275006032 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 885275006033 Flagellin protein; Region: FliC; pfam12445 885275006034 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 885275006035 flagellar capping protein; Reviewed; Region: fliD; PRK08032 885275006036 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 885275006037 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 885275006038 Flagellar protein FliS; Region: FliS; cl00654 885275006039 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 885275006040 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 885275006041 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 885275006042 active site 885275006043 Na/Ca binding site [ion binding]; other site 885275006044 catalytic site [active] 885275006045 lipoprotein; Provisional; Region: PRK10397 885275006046 putative inner membrane protein; Provisional; Region: PRK11099 885275006047 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 885275006048 CPxP motif; other site 885275006049 hypothetical protein; Provisional; Region: PRK09951 885275006050 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 885275006051 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 885275006052 trimer interface [polypeptide binding]; other site 885275006053 eyelet of channel; other site 885275006054 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 885275006055 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 885275006056 substrate binding site [chemical binding]; other site 885275006057 multidrug efflux protein; Reviewed; Region: emrE; PRK09541 885275006058 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 885275006059 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 885275006060 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 885275006061 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 885275006062 flagellar motor switch protein FliG; Region: fliG; TIGR00207 885275006063 FliG C-terminal domain; Region: FliG_C; pfam01706 885275006064 flagellar assembly protein H; Validated; Region: fliH; PRK05687 885275006065 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 885275006066 Flagellar assembly protein FliH; Region: FliH; pfam02108 885275006067 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 885275006068 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 885275006069 Walker A motif/ATP binding site; other site 885275006070 Walker B motif; other site 885275006071 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 885275006072 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 885275006073 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 885275006074 flagellar hook-length control protein; Provisional; Region: PRK10118 885275006075 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 885275006076 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 885275006077 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 885275006078 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 885275006079 flagellar motor switch protein; Validated; Region: fliN; PRK05698 885275006080 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 885275006081 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 885275006082 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 885275006083 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 885275006084 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 885275006085 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885275006086 DNA binding residues [nucleotide binding] 885275006087 dimerization interface [polypeptide binding]; other site 885275006088 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 885275006089 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 885275006090 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885275006091 active site 885275006092 motif I; other site 885275006093 motif II; other site 885275006094 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 885275006095 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885275006096 metal binding site [ion binding]; metal-binding site 885275006097 active site 885275006098 I-site; other site 885275006099 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 885275006100 hypothetical protein; Provisional; Region: PRK10062 885275006101 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 885275006102 EamA-like transporter family; Region: EamA; pfam00892 885275006103 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 885275006104 additional DNA contacts [nucleotide binding]; other site 885275006105 mismatch recognition site; other site 885275006106 active site 885275006107 zinc binding site [ion binding]; other site 885275006108 DNA intercalation site [nucleotide binding]; other site 885275006109 DNA cytosine methylase; Provisional; Region: PRK10458 885275006110 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 885275006111 cofactor binding site; other site 885275006112 DNA binding site [nucleotide binding] 885275006113 substrate interaction site [chemical binding]; other site 885275006114 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 885275006115 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 885275006116 Zn2+ binding site [ion binding]; other site 885275006117 Mg2+ binding site [ion binding]; other site 885275006118 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 885275006119 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 885275006120 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 885275006121 trimer interface [polypeptide binding]; other site 885275006122 eyelet of channel; other site 885275006123 chaperone protein HchA; Provisional; Region: PRK04155 885275006124 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 885275006125 dimer interface [polypeptide binding]; other site 885275006126 metal binding site [ion binding]; metal-binding site 885275006127 potential oxyanion hole; other site 885275006128 potential catalytic triad [active] 885275006129 conserved cys residue [active] 885275006130 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 885275006131 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885275006132 dimer interface [polypeptide binding]; other site 885275006133 phosphorylation site [posttranslational modification] 885275006134 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275006135 ATP binding site [chemical binding]; other site 885275006136 Mg2+ binding site [ion binding]; other site 885275006137 G-X-G motif; other site 885275006138 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 885275006139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275006140 active site 885275006141 phosphorylation site [posttranslational modification] 885275006142 intermolecular recognition site; other site 885275006143 dimerization interface [polypeptide binding]; other site 885275006144 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 885275006145 DNA binding site [nucleotide binding] 885275006146 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 885275006147 active site 885275006148 homotetramer interface [polypeptide binding]; other site 885275006149 TMAO/DMSO reductase; Reviewed; Region: PRK05363 885275006150 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 885275006151 Moco binding site; other site 885275006152 metal coordination site [ion binding]; other site 885275006153 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 885275006154 zinc/cadmium-binding protein; Provisional; Region: PRK10306 885275006155 integrase; Provisional; Region: PRK09692 885275006156 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 885275006157 active site 885275006158 Int/Topo IB signature motif; other site 885275006159 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 885275006160 PilS N terminal; Region: PilS; pfam08805 885275006161 Conjugal transfer protein TraD; Region: TraD; pfam06412 885275006162 MobA/MobL family; Region: MobA_MobL; pfam03389 885275006163 TIR domain; Region: TIR_2; pfam13676 885275006164 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 885275006165 potential frameshift: common BLAST hit: gi|207857426|ref|YP_002244077.1| exported protein 885275006166 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 885275006167 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 885275006168 Ubiquitin elongating factor core; Region: Ufd2P_core; pfam10408 885275006169 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 885275006170 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 885275006171 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 885275006172 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 885275006173 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 885275006174 active site 885275006175 Int/Topo IB signature motif; other site 885275006176 salicylate synthase Irp9; Reviewed; Region: PRK06772 885275006177 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 885275006178 muropeptide transporter; Validated; Region: ampG; cl17669 885275006179 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 885275006180 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885275006181 Walker A/P-loop; other site 885275006182 ATP binding site [chemical binding]; other site 885275006183 Q-loop/lid; other site 885275006184 ABC transporter signature motif; other site 885275006185 Walker B; other site 885275006186 D-loop; other site 885275006187 H-loop/switch region; other site 885275006188 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 885275006189 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 885275006190 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885275006191 Walker A/P-loop; other site 885275006192 ATP binding site [chemical binding]; other site 885275006193 Q-loop/lid; other site 885275006194 ABC transporter signature motif; other site 885275006195 Walker B; other site 885275006196 D-loop; other site 885275006197 H-loop/switch region; other site 885275006198 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 885275006199 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275006200 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 885275006201 Condensation domain; Region: Condensation; pfam00668 885275006202 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 885275006203 Nonribosomal peptide synthase; Region: NRPS; pfam08415 885275006204 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 885275006205 acyl-activating enzyme (AAE) consensus motif; other site 885275006206 AMP binding site [chemical binding]; other site 885275006207 Methyltransferase domain; Region: Methyltransf_23; pfam13489 885275006208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275006209 S-adenosylmethionine binding site [chemical binding]; other site 885275006210 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 885275006211 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885275006212 Condensation domain; Region: Condensation; pfam00668 885275006213 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 885275006214 Nonribosomal peptide synthase; Region: NRPS; pfam08415 885275006215 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885275006216 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 885275006217 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 885275006218 active site 885275006219 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 885275006220 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 885275006221 Methyltransferase domain; Region: Methyltransf_12; pfam08242 885275006222 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 885275006223 KR domain; Region: KR; pfam08659 885275006224 NADP binding site [chemical binding]; other site 885275006225 active site 885275006226 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885275006227 Condensation domain; Region: Condensation; pfam00668 885275006228 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 885275006229 Nonribosomal peptide synthase; Region: NRPS; pfam08415 885275006230 Methyltransferase domain; Region: Methyltransf_12; pfam08242 885275006231 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885275006232 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 885275006233 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 885275006234 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 885275006235 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 885275006236 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 885275006237 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 885275006238 acyl-activating enzyme (AAE) consensus motif; other site 885275006239 active site 885275006240 AMP binding site [chemical binding]; other site 885275006241 substrate binding site [chemical binding]; other site 885275006242 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 885275006243 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885275006244 N-terminal plug; other site 885275006245 ligand-binding site [chemical binding]; other site 885275006246 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 885275006247 potential frameshift: common BLAST hit: gi|117624169|ref|YP_853082.1| autotransporter 885275006248 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 885275006249 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 885275006250 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 885275006251 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 885275006252 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 885275006253 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 885275006254 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 885275006255 shikimate transporter; Provisional; Region: PRK09952 885275006256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275006257 putative substrate translocation pore; other site 885275006258 AMP nucleosidase; Provisional; Region: PRK08292 885275006259 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 885275006260 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 885275006261 hypothetical protein; Provisional; Region: PRK12378 885275006262 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 885275006263 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275006264 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 885275006265 putative dimerization interface [polypeptide binding]; other site 885275006266 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 885275006267 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275006268 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 885275006269 putative substrate binding site [chemical binding]; other site 885275006270 dimerization interface [polypeptide binding]; other site 885275006271 MATE family multidrug exporter; Provisional; Region: PRK10189 885275006272 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 885275006273 integrase; Provisional; Region: PRK09692 885275006274 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 885275006275 active site 885275006276 Int/Topo IB signature motif; other site 885275006277 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 885275006278 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 885275006279 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 885275006280 Beta-lactamase; Region: Beta-lactamase; pfam00144 885275006281 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 885275006282 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 885275006283 active site 885275006284 Condensation domain; Region: Condensation; pfam00668 885275006285 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 885275006286 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 885275006287 acyl-activating enzyme (AAE) consensus motif; other site 885275006288 AMP binding site [chemical binding]; other site 885275006289 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885275006290 Condensation domain; Region: Condensation; pfam00668 885275006291 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 885275006292 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_6; cd13146 885275006293 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 885275006294 amidase; Provisional; Region: PRK06170 885275006295 Amidase; Region: Amidase; cl11426 885275006296 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 885275006297 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 885275006298 active site 885275006299 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885275006300 Condensation domain; Region: Condensation; pfam00668 885275006301 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 885275006302 Nonribosomal peptide synthase; Region: NRPS; pfam08415 885275006303 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 885275006304 acyl-activating enzyme (AAE) consensus motif; other site 885275006305 AMP binding site [chemical binding]; other site 885275006306 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 885275006307 putative FMN binding site [chemical binding]; other site 885275006308 NADPH bind site [chemical binding]; other site 885275006309 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 885275006310 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885275006311 Condensation domain; Region: Condensation; pfam00668 885275006312 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 885275006313 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 885275006314 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 885275006315 acyl-activating enzyme (AAE) consensus motif; other site 885275006316 AMP binding site [chemical binding]; other site 885275006317 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885275006318 Condensation domain; Region: Condensation; pfam00668 885275006319 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 885275006320 Nonribosomal peptide synthase; Region: NRPS; pfam08415 885275006321 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 885275006322 acyl-activating enzyme (AAE) consensus motif; other site 885275006323 AMP binding site [chemical binding]; other site 885275006324 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885275006325 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 885275006326 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 885275006327 active site 885275006328 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 885275006329 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 885275006330 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885275006331 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 885275006332 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 885275006333 acyl-activating enzyme (AAE) consensus motif; other site 885275006334 AMP binding site [chemical binding]; other site 885275006335 Condensation domain; Region: Condensation; pfam00668 885275006336 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 885275006337 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 885275006338 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 885275006339 acyl-activating enzyme (AAE) consensus motif; other site 885275006340 AMP binding site [chemical binding]; other site 885275006341 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885275006342 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 885275006343 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 885275006344 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 885275006345 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 885275006346 active site 885275006347 acyl carrier protein; Provisional; Region: PRK07081 885275006348 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 885275006349 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 885275006350 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 885275006351 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 885275006352 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 885275006353 active site 885275006354 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885275006355 Condensation domain; Region: Condensation; pfam00668 885275006356 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 885275006357 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 885275006358 acyl-activating enzyme (AAE) consensus motif; other site 885275006359 AMP binding site [chemical binding]; other site 885275006360 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885275006361 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 885275006362 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 885275006363 active site 885275006364 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 885275006365 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 885275006366 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 885275006367 KR domain; Region: KR; pfam08659 885275006368 putative NADP binding site [chemical binding]; other site 885275006369 active site 885275006370 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 885275006371 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 885275006372 Enoylreductase; Region: PKS_ER; smart00829 885275006373 NAD(P) binding site [chemical binding]; other site 885275006374 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885275006375 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 885275006376 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 885275006377 DNA-binding interface [nucleotide binding]; DNA binding site 885275006378 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 885275006379 Integrase core domain; Region: rve; pfam00665 885275006380 Integrase core domain; Region: rve_3; pfam13683 885275006381 Integrase core domain; Region: rve_2; pfam13333 885275006382 L,D-transpeptidase; Provisional; Region: PRK10190 885275006383 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 885275006384 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 885275006385 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 885275006386 putative dimer interface [polypeptide binding]; other site 885275006387 active site pocket [active] 885275006388 putative cataytic base [active] 885275006389 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 885275006390 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 885275006391 homotrimer interface [polypeptide binding]; other site 885275006392 Walker A motif; other site 885275006393 GTP binding site [chemical binding]; other site 885275006394 Walker B motif; other site 885275006395 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 885275006396 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885275006397 N-terminal plug; other site 885275006398 ligand-binding site [chemical binding]; other site 885275006399 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 885275006400 ParB-like nuclease domain; Region: ParBc; cl02129 885275006401 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 885275006402 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 885275006403 Active Sites [active] 885275006404 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 885275006405 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 885275006406 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 885275006407 putative trimer interface [polypeptide binding]; other site 885275006408 putative CoA binding site [chemical binding]; other site 885275006409 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 885275006410 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 885275006411 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 885275006412 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 885275006413 substrate binding site [chemical binding]; other site 885275006414 dimer interface [polypeptide binding]; other site 885275006415 ATP binding site [chemical binding]; other site 885275006416 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 885275006417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 885275006418 Protein of unknown function, DUF606; Region: DUF606; pfam04657 885275006419 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 885275006420 active site 885275006421 substrate binding pocket [chemical binding]; other site 885275006422 homodimer interaction site [polypeptide binding]; other site 885275006423 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 885275006424 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 885275006425 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 885275006426 Haemolysin expression modulating protein; Region: HHA; cl11501 885275006427 Transposase; Region: DEDD_Tnp_IS110; pfam01548 885275006428 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 885275006429 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 885275006430 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 885275006431 transposase/IS protein; Provisional; Region: PRK09183 885275006432 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275006433 Walker A motif; other site 885275006434 ATP binding site [chemical binding]; other site 885275006435 Walker B motif; other site 885275006436 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 885275006437 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 885275006438 DNA-binding interface [nucleotide binding]; DNA binding site 885275006439 Integrase core domain; Region: rve; pfam00665 885275006440 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 885275006441 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 885275006442 Walker A/P-loop; other site 885275006443 ATP binding site [chemical binding]; other site 885275006444 Q-loop/lid; other site 885275006445 ABC transporter signature motif; other site 885275006446 Walker B; other site 885275006447 D-loop; other site 885275006448 H-loop/switch region; other site 885275006449 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 885275006450 dimer interface [polypeptide binding]; other site 885275006451 putative PBP binding regions; other site 885275006452 ABC-ATPase subunit interface; other site 885275006453 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 885275006454 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 885275006455 putative ligand binding residues [chemical binding]; other site 885275006456 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 885275006457 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885275006458 N-terminal plug; other site 885275006459 ligand-binding site [chemical binding]; other site 885275006460 hypothetical protein; Provisional; Region: PRK09866 885275006461 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 885275006462 G1 box; other site 885275006463 GTP/Mg2+ binding site [chemical binding]; other site 885275006464 G2 box; other site 885275006465 Switch I region; other site 885275006466 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 885275006467 G3 box; other site 885275006468 Switch II region; other site 885275006469 GTP/Mg2+ binding site [chemical binding]; other site 885275006470 G4 box; other site 885275006471 G5 box; other site 885275006472 YjcZ-like protein; Region: YjcZ; pfam13990 885275006473 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 885275006474 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 885275006475 nucleophile elbow; other site 885275006476 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 885275006477 Domain of unknown function (DUF932); Region: DUF932; pfam06067 885275006478 Protein of unknown function (DUF987); Region: DUF987; pfam06174 885275006479 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 885275006480 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 885275006481 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 885275006482 Switch II region; other site 885275006483 G4 box; other site 885275006484 G5 box; other site 885275006485 hypothetical protein; Provisional; Region: PRK05423 885275006486 Predicted membrane protein [Function unknown]; Region: COG1289 885275006487 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 885275006488 DNA gyrase inhibitor; Provisional; Region: PRK10016 885275006489 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 885275006490 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 885275006491 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 885275006492 exonuclease I; Provisional; Region: sbcB; PRK11779 885275006493 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 885275006494 active site 885275006495 catalytic site [active] 885275006496 substrate binding site [chemical binding]; other site 885275006497 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 885275006498 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 885275006499 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275006500 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 885275006501 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 885275006502 dimerization interface [polypeptide binding]; other site 885275006503 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 885275006504 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 885275006505 putative NAD(P) binding site [chemical binding]; other site 885275006506 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 885275006507 antitoxin YefM; Provisional; Region: PRK11409 885275006508 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 885275006509 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 885275006510 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 885275006511 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 885275006512 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 885275006513 NAD binding site [chemical binding]; other site 885275006514 dimerization interface [polypeptide binding]; other site 885275006515 product binding site; other site 885275006516 substrate binding site [chemical binding]; other site 885275006517 zinc binding site [ion binding]; other site 885275006518 catalytic residues [active] 885275006519 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 885275006520 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 885275006521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275006522 homodimer interface [polypeptide binding]; other site 885275006523 catalytic residue [active] 885275006524 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 885275006525 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885275006526 active site 885275006527 motif I; other site 885275006528 motif II; other site 885275006529 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 885275006530 putative active site pocket [active] 885275006531 4-fold oligomerization interface [polypeptide binding]; other site 885275006532 metal binding residues [ion binding]; metal-binding site 885275006533 3-fold/trimer interface [polypeptide binding]; other site 885275006534 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 885275006535 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 885275006536 putative active site [active] 885275006537 oxyanion strand; other site 885275006538 catalytic triad [active] 885275006539 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 885275006540 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 885275006541 catalytic residues [active] 885275006542 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 885275006543 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 885275006544 substrate binding site [chemical binding]; other site 885275006545 glutamase interaction surface [polypeptide binding]; other site 885275006546 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 885275006547 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 885275006548 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 885275006549 metal binding site [ion binding]; metal-binding site 885275006550 chain length determinant protein WzzB; Provisional; Region: PRK15471 885275006551 Chain length determinant protein; Region: Wzz; pfam02706 885275006552 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 885275006553 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 885275006554 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 885275006555 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 885275006556 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 885275006557 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 885275006558 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 885275006559 phosphomannomutase CpsG; Provisional; Region: PRK15414 885275006560 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 885275006561 active site 885275006562 substrate binding site [chemical binding]; other site 885275006563 metal binding site [ion binding]; metal-binding site 885275006564 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 885275006565 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 885275006566 Substrate binding site; other site 885275006567 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 885275006568 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 885275006569 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 885275006570 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 885275006571 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 885275006572 NAD binding site [chemical binding]; other site 885275006573 homodimer interface [polypeptide binding]; other site 885275006574 active site 885275006575 substrate binding site [chemical binding]; other site 885275006576 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 885275006577 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 885275006578 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 885275006579 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 885275006580 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 885275006581 active site 885275006582 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 885275006583 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 885275006584 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 885275006585 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 885275006586 active site 885275006587 tetramer interface; other site 885275006588 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 885275006589 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 885275006590 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 885275006591 putative ADP-binding pocket [chemical binding]; other site 885275006592 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 885275006593 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 885275006594 colanic acid exporter; Provisional; Region: PRK10459 885275006595 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 885275006596 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 885275006597 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 885275006598 phosphomannomutase CpsG; Provisional; Region: PRK15414 885275006599 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 885275006600 active site 885275006601 substrate binding site [chemical binding]; other site 885275006602 metal binding site [ion binding]; metal-binding site 885275006603 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 885275006604 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 885275006605 Substrate binding site; other site 885275006606 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 885275006607 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 885275006608 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 885275006609 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 885275006610 active site 885275006611 GDP-Mannose binding site [chemical binding]; other site 885275006612 dimer interface [polypeptide binding]; other site 885275006613 modified nudix motif 885275006614 metal binding site [ion binding]; metal-binding site 885275006615 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 885275006616 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 885275006617 NADP binding site [chemical binding]; other site 885275006618 active site 885275006619 putative substrate binding site [chemical binding]; other site 885275006620 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 885275006621 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 885275006622 NADP-binding site; other site 885275006623 homotetramer interface [polypeptide binding]; other site 885275006624 substrate binding site [chemical binding]; other site 885275006625 homodimer interface [polypeptide binding]; other site 885275006626 active site 885275006627 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 885275006628 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 885275006629 putative trimer interface [polypeptide binding]; other site 885275006630 putative active site [active] 885275006631 putative substrate binding site [chemical binding]; other site 885275006632 putative CoA binding site [chemical binding]; other site 885275006633 putative glycosyl transferase; Provisional; Region: PRK10063 885275006634 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 885275006635 metal-binding site 885275006636 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 885275006637 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 885275006638 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 885275006639 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 885275006640 putative acyl transferase; Provisional; Region: PRK10191 885275006641 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 885275006642 trimer interface [polypeptide binding]; other site 885275006643 active site 885275006644 substrate binding site [chemical binding]; other site 885275006645 CoA binding site [chemical binding]; other site 885275006646 putative glycosyl transferase; Provisional; Region: PRK10018 885275006647 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 885275006648 active site 885275006649 tyrosine kinase; Provisional; Region: PRK11519 885275006650 Chain length determinant protein; Region: Wzz; pfam02706 885275006651 Chain length determinant protein; Region: Wzz; cl15801 885275006652 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 885275006653 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 885275006654 Low molecular weight phosphatase family; Region: LMWPc; cd00115 885275006655 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 885275006656 active site 885275006657 polysaccharide export protein Wza; Provisional; Region: PRK15078 885275006658 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 885275006659 SLBB domain; Region: SLBB; pfam10531 885275006660 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 885275006661 FOG: CBS domain [General function prediction only]; Region: COG0517 885275006662 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 885275006663 Transporter associated domain; Region: CorC_HlyC; smart01091 885275006664 putative assembly protein; Provisional; Region: PRK10833 885275006665 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 885275006666 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 885275006667 trimer interface [polypeptide binding]; other site 885275006668 active site 885275006669 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 885275006670 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 885275006671 ATP-binding site [chemical binding]; other site 885275006672 Sugar specificity; other site 885275006673 Pyrimidine base specificity; other site 885275006674 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 885275006675 putative diguanylate cyclase; Provisional; Region: PRK09776 885275006676 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 885275006677 putative active site [active] 885275006678 heme pocket [chemical binding]; other site 885275006679 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 885275006680 putative active site [active] 885275006681 heme pocket [chemical binding]; other site 885275006682 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 885275006683 putative active site [active] 885275006684 heme pocket [chemical binding]; other site 885275006685 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885275006686 metal binding site [ion binding]; metal-binding site 885275006687 active site 885275006688 I-site; other site 885275006689 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885275006690 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 885275006691 AlkA N-terminal domain; Region: AlkA_N; smart01009 885275006692 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 885275006693 minor groove reading motif; other site 885275006694 helix-hairpin-helix signature motif; other site 885275006695 substrate binding pocket [chemical binding]; other site 885275006696 active site 885275006697 putative chaperone; Provisional; Region: PRK11678 885275006698 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 885275006699 nucleotide binding site [chemical binding]; other site 885275006700 putative NEF/HSP70 interaction site [polypeptide binding]; other site 885275006701 SBD interface [polypeptide binding]; other site 885275006702 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 885275006703 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 885275006704 substrate binding site [chemical binding]; other site 885275006705 activation loop (A-loop); other site 885275006706 Protein phosphatase 2C; Region: PP2C_2; pfam13672 885275006707 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 885275006708 metal ion-dependent adhesion site (MIDAS); other site 885275006709 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 885275006710 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885275006711 HlyD family secretion protein; Region: HlyD_3; pfam13437 885275006712 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 885275006713 Protein export membrane protein; Region: SecD_SecF; cl14618 885275006714 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 885275006715 putative transporter; Provisional; Region: PRK10504 885275006716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275006717 putative substrate translocation pore; other site 885275006718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 885275006719 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 885275006720 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 885275006721 dimerization interface [polypeptide binding]; other site 885275006722 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885275006723 dimer interface [polypeptide binding]; other site 885275006724 phosphorylation site [posttranslational modification] 885275006725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275006726 ATP binding site [chemical binding]; other site 885275006727 Mg2+ binding site [ion binding]; other site 885275006728 G-X-G motif; other site 885275006729 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 885275006730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275006731 active site 885275006732 phosphorylation site [posttranslational modification] 885275006733 intermolecular recognition site; other site 885275006734 dimerization interface [polypeptide binding]; other site 885275006735 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 885275006736 DNA binding site [nucleotide binding] 885275006737 Uncharacterized conserved protein [Function unknown]; Region: COG3422 885275006738 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 885275006739 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 885275006740 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 885275006741 PcfJ-like protein; Region: PcfJ; pfam14284 885275006742 putative protease; Provisional; Region: PRK15452 885275006743 Peptidase family U32; Region: Peptidase_U32; pfam01136 885275006744 lipid kinase; Reviewed; Region: PRK13054 885275006745 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 885275006746 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 885275006747 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 885275006748 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 885275006749 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 885275006750 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 885275006751 putative NAD(P) binding site [chemical binding]; other site 885275006752 catalytic Zn binding site [ion binding]; other site 885275006753 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 885275006754 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 885275006755 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 885275006756 active site 885275006757 P-loop; other site 885275006758 phosphorylation site [posttranslational modification] 885275006759 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 885275006760 active site 885275006761 phosphorylation site [posttranslational modification] 885275006762 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 885275006763 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 885275006764 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 885275006765 intersubunit interface [polypeptide binding]; other site 885275006766 active site 885275006767 zinc binding site [ion binding]; other site 885275006768 Na+ binding site [ion binding]; other site 885275006769 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 885275006770 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 885275006771 putative active site; other site 885275006772 catalytic residue [active] 885275006773 nucleoside transporter; Region: 2A0110; TIGR00889 885275006774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275006775 putative substrate translocation pore; other site 885275006776 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 885275006777 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 885275006778 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 885275006779 substrate binding site [chemical binding]; other site 885275006780 ATP binding site [chemical binding]; other site 885275006781 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 885275006782 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885275006783 DNA-binding site [nucleotide binding]; DNA binding site 885275006784 UTRA domain; Region: UTRA; pfam07702 885275006785 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 885275006786 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 885275006787 active site 885275006788 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 885275006789 dimer interface [polypeptide binding]; other site 885275006790 substrate binding site [chemical binding]; other site 885275006791 ATP binding site [chemical binding]; other site 885275006792 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 885275006793 substrate binding site [chemical binding]; other site 885275006794 multimerization interface [polypeptide binding]; other site 885275006795 ATP binding site [chemical binding]; other site 885275006796 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 885275006797 putative metal binding site [ion binding]; other site 885275006798 putative homodimer interface [polypeptide binding]; other site 885275006799 putative homotetramer interface [polypeptide binding]; other site 885275006800 putative homodimer-homodimer interface [polypeptide binding]; other site 885275006801 putative allosteric switch controlling residues; other site 885275006802 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 885275006803 Predicted integral membrane protein [Function unknown]; Region: COG5455 885275006804 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 885275006805 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 885275006806 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 885275006807 PapC N-terminal domain; Region: PapC_N; pfam13954 885275006808 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 885275006809 PapC C-terminal domain; Region: PapC_C; pfam13953 885275006810 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 885275006811 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 885275006812 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 885275006813 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 885275006814 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 885275006815 antiporter inner membrane protein; Provisional; Region: PRK11670 885275006816 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 885275006817 Walker A motif; other site 885275006818 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 885275006819 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 885275006820 active site 885275006821 HIGH motif; other site 885275006822 KMSKS motif; other site 885275006823 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 885275006824 tRNA binding surface [nucleotide binding]; other site 885275006825 anticodon binding site; other site 885275006826 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 885275006827 dimer interface [polypeptide binding]; other site 885275006828 putative tRNA-binding site [nucleotide binding]; other site 885275006829 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 885275006830 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 885275006831 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 885275006832 MoxR-like ATPases [General function prediction only]; Region: COG0714 885275006833 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 885275006834 Walker A motif; other site 885275006835 ATP binding site [chemical binding]; other site 885275006836 Walker B motif; other site 885275006837 arginine finger; other site 885275006838 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 885275006839 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 885275006840 metal ion-dependent adhesion site (MIDAS); other site 885275006841 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 885275006842 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 885275006843 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 885275006844 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 885275006845 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 885275006846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275006847 active site 885275006848 phosphorylation site [posttranslational modification] 885275006849 intermolecular recognition site; other site 885275006850 dimerization interface [polypeptide binding]; other site 885275006851 LytTr DNA-binding domain; Region: LytTR; pfam04397 885275006852 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 885275006853 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 885275006854 GAF domain; Region: GAF; pfam01590 885275006855 Histidine kinase; Region: His_kinase; pfam06580 885275006856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275006857 ATP binding site [chemical binding]; other site 885275006858 Mg2+ binding site [ion binding]; other site 885275006859 G-X-G motif; other site 885275006860 transcriptional regulator MirA; Provisional; Region: PRK15043 885275006861 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 885275006862 DNA binding residues [nucleotide binding] 885275006863 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 885275006864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275006865 dimer interface [polypeptide binding]; other site 885275006866 conserved gate region; other site 885275006867 putative PBP binding loops; other site 885275006868 ABC-ATPase subunit interface; other site 885275006869 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 885275006870 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 885275006871 Walker A/P-loop; other site 885275006872 ATP binding site [chemical binding]; other site 885275006873 Q-loop/lid; other site 885275006874 ABC transporter signature motif; other site 885275006875 Walker B; other site 885275006876 D-loop; other site 885275006877 H-loop/switch region; other site 885275006878 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 885275006879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275006880 dimer interface [polypeptide binding]; other site 885275006881 conserved gate region; other site 885275006882 ABC-ATPase subunit interface; other site 885275006883 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 885275006884 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 885275006885 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 885275006886 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 885275006887 D-lactate dehydrogenase; Provisional; Region: PRK11183 885275006888 FAD binding domain; Region: FAD_binding_4; pfam01565 885275006889 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 885275006890 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 885275006891 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 885275006892 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 885275006893 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 885275006894 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 885275006895 classical (c) SDRs; Region: SDR_c; cd05233 885275006896 active site 885275006897 classical (c) SDRs; Region: SDR_c; cd05233 885275006898 NAD(P) binding site [chemical binding]; other site 885275006899 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 885275006900 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 885275006901 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 885275006902 FMN binding site [chemical binding]; other site 885275006903 active site 885275006904 catalytic residues [active] 885275006905 substrate binding site [chemical binding]; other site 885275006906 hypothetical protein; Provisional; Region: PRK01821 885275006907 hypothetical protein; Provisional; Region: PRK10711 885275006908 cytidine deaminase; Provisional; Region: PRK09027 885275006909 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 885275006910 active site 885275006911 catalytic motif [active] 885275006912 Zn binding site [ion binding]; other site 885275006913 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 885275006914 active site 885275006915 catalytic motif [active] 885275006916 Zn binding site [ion binding]; other site 885275006917 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 885275006918 putative active site [active] 885275006919 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 885275006920 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 885275006921 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 885275006922 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 885275006923 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 885275006924 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 885275006925 homodimer interface [polypeptide binding]; other site 885275006926 active site 885275006927 FMN binding site [chemical binding]; other site 885275006928 substrate binding site [chemical binding]; other site 885275006929 4Fe-4S binding domain; Region: Fer4; pfam00037 885275006930 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 885275006931 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 885275006932 TM-ABC transporter signature motif; other site 885275006933 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 885275006934 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 885275006935 Walker A/P-loop; other site 885275006936 ATP binding site [chemical binding]; other site 885275006937 Q-loop/lid; other site 885275006938 ABC transporter signature motif; other site 885275006939 Walker B; other site 885275006940 D-loop; other site 885275006941 H-loop/switch region; other site 885275006942 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 885275006943 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 885275006944 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 885275006945 ligand binding site [chemical binding]; other site 885275006946 calcium binding site [ion binding]; other site 885275006947 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 885275006948 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 885275006949 DNA binding site [nucleotide binding] 885275006950 domain linker motif; other site 885275006951 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 885275006952 dimerization interface (closed form) [polypeptide binding]; other site 885275006953 ligand binding site [chemical binding]; other site 885275006954 Predicted membrane protein [Function unknown]; Region: COG2311 885275006955 hypothetical protein; Provisional; Region: PRK10835 885275006956 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 885275006957 homodecamer interface [polypeptide binding]; other site 885275006958 GTP cyclohydrolase I; Provisional; Region: PLN03044 885275006959 active site 885275006960 putative catalytic site residues [active] 885275006961 zinc binding site [ion binding]; other site 885275006962 GTP-CH-I/GFRP interaction surface; other site 885275006963 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 885275006964 S-formylglutathione hydrolase; Region: PLN02442 885275006965 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 885275006966 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885275006967 N-terminal plug; other site 885275006968 ligand-binding site [chemical binding]; other site 885275006969 lysine transporter; Provisional; Region: PRK10836 885275006970 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 885275006971 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275006972 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 885275006973 putative dimerization interface [polypeptide binding]; other site 885275006974 conserved hypothetical integral membrane protein; Region: TIGR00698 885275006975 endonuclease IV; Provisional; Region: PRK01060 885275006976 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 885275006977 AP (apurinic/apyrimidinic) site pocket; other site 885275006978 DNA interaction; other site 885275006979 Metal-binding active site; metal-binding site 885275006980 putative kinase; Provisional; Region: PRK09954 885275006981 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 885275006982 putative DNA binding site [nucleotide binding]; other site 885275006983 putative Zn2+ binding site [ion binding]; other site 885275006984 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 885275006985 substrate binding site [chemical binding]; other site 885275006986 ATP binding site [chemical binding]; other site 885275006987 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 885275006988 active site 885275006989 tetramer interface [polypeptide binding]; other site 885275006990 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 885275006991 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 885275006992 ligand binding site [chemical binding]; other site 885275006993 flexible hinge region; other site 885275006994 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 885275006995 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 885275006996 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 885275006997 Nucleoside recognition; Region: Gate; pfam07670 885275006998 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 885275006999 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 885275007000 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 885275007001 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 885275007002 substrate binding site [chemical binding]; other site 885275007003 ATP binding site [chemical binding]; other site 885275007004 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 885275007005 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 885275007006 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 885275007007 active site 885275007008 P-loop; other site 885275007009 phosphorylation site [posttranslational modification] 885275007010 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 885275007011 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 885275007012 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 885275007013 putative substrate binding site [chemical binding]; other site 885275007014 putative ATP binding site [chemical binding]; other site 885275007015 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 885275007016 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 885275007017 active site 885275007018 phosphorylation site [posttranslational modification] 885275007019 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 885275007020 dimerization domain swap beta strand [polypeptide binding]; other site 885275007021 regulatory protein interface [polypeptide binding]; other site 885275007022 active site 885275007023 regulatory phosphorylation site [posttranslational modification]; other site 885275007024 sugar efflux transporter B; Provisional; Region: PRK15011 885275007025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275007026 putative substrate translocation pore; other site 885275007027 elongation factor P; Provisional; Region: PRK04542 885275007028 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 885275007029 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 885275007030 RNA binding site [nucleotide binding]; other site 885275007031 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 885275007032 RNA binding site [nucleotide binding]; other site 885275007033 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 885275007034 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 885275007035 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 885275007036 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 885275007037 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 885275007038 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 885275007039 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 885275007040 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 885275007041 active site 885275007042 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 885275007043 NlpC/P60 family; Region: NLPC_P60; pfam00877 885275007044 phage resistance protein; Provisional; Region: PRK10551 885275007045 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 885275007046 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885275007047 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 885275007048 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 885275007049 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 885275007050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275007051 dimer interface [polypeptide binding]; other site 885275007052 conserved gate region; other site 885275007053 putative PBP binding loops; other site 885275007054 ABC-ATPase subunit interface; other site 885275007055 microcin C ABC transporter permease; Provisional; Region: PRK15021 885275007056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275007057 dimer interface [polypeptide binding]; other site 885275007058 conserved gate region; other site 885275007059 ABC-ATPase subunit interface; other site 885275007060 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 885275007061 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 885275007062 Walker A/P-loop; other site 885275007063 ATP binding site [chemical binding]; other site 885275007064 Q-loop/lid; other site 885275007065 ABC transporter signature motif; other site 885275007066 Walker B; other site 885275007067 D-loop; other site 885275007068 H-loop/switch region; other site 885275007069 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 885275007070 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 885275007071 Walker A/P-loop; other site 885275007072 ATP binding site [chemical binding]; other site 885275007073 Q-loop/lid; other site 885275007074 ABC transporter signature motif; other site 885275007075 Walker B; other site 885275007076 D-loop; other site 885275007077 H-loop/switch region; other site 885275007078 hypothetical protein; Provisional; Region: PRK11835 885275007079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275007080 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 885275007081 putative substrate translocation pore; other site 885275007082 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 885275007083 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 885275007084 RNA binding surface [nucleotide binding]; other site 885275007085 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 885275007086 active site 885275007087 uracil binding [chemical binding]; other site 885275007088 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 885275007089 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 885275007090 ATP binding site [chemical binding]; other site 885275007091 putative Mg++ binding site [ion binding]; other site 885275007092 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 885275007093 nucleotide binding region [chemical binding]; other site 885275007094 ATP-binding site [chemical binding]; other site 885275007095 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 885275007096 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 885275007097 5S rRNA interface [nucleotide binding]; other site 885275007098 CTC domain interface [polypeptide binding]; other site 885275007099 L16 interface [polypeptide binding]; other site 885275007100 Nucleoid-associated protein [General function prediction only]; Region: COG3081 885275007101 nucleoid-associated protein NdpA; Validated; Region: PRK00378 885275007102 hypothetical protein; Provisional; Region: PRK13689 885275007103 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 885275007104 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 885275007105 Sulfatase; Region: Sulfatase; pfam00884 885275007106 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 885275007107 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 885275007108 transcriptional regulator NarP; Provisional; Region: PRK10403 885275007109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275007110 active site 885275007111 phosphorylation site [posttranslational modification] 885275007112 intermolecular recognition site; other site 885275007113 dimerization interface [polypeptide binding]; other site 885275007114 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885275007115 DNA binding residues [nucleotide binding] 885275007116 dimerization interface [polypeptide binding]; other site 885275007117 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 885275007118 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 885275007119 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 885275007120 binding surface 885275007121 TPR motif; other site 885275007122 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 885275007123 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 885275007124 catalytic residues [active] 885275007125 central insert; other site 885275007126 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 885275007127 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 885275007128 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 885275007129 heme exporter protein CcmC; Region: ccmC; TIGR01191 885275007130 heme exporter protein CcmB; Region: ccmB; TIGR01190 885275007131 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 885275007132 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 885275007133 Walker A/P-loop; other site 885275007134 ATP binding site [chemical binding]; other site 885275007135 Q-loop/lid; other site 885275007136 ABC transporter signature motif; other site 885275007137 Walker B; other site 885275007138 D-loop; other site 885275007139 H-loop/switch region; other site 885275007140 cytochrome c-type protein NapC; Provisional; Region: PRK10617 885275007141 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 885275007142 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 885275007143 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 885275007144 4Fe-4S binding domain; Region: Fer4_5; pfam12801 885275007145 4Fe-4S binding domain; Region: Fer4; cl02805 885275007146 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 885275007147 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 885275007148 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 885275007149 [4Fe-4S] binding site [ion binding]; other site 885275007150 molybdopterin cofactor binding site; other site 885275007151 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 885275007152 molybdopterin cofactor binding site; other site 885275007153 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 885275007154 ferredoxin-type protein; Provisional; Region: PRK10194 885275007155 tRNA synthetases class I (R); Region: tRNA-synt_1d; pfam00750 885275007156 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 885275007157 secondary substrate binding site; other site 885275007158 primary substrate binding site; other site 885275007159 inhibition loop; other site 885275007160 dimerization interface [polypeptide binding]; other site 885275007161 malate:quinone oxidoreductase; Validated; Region: PRK05257 885275007162 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 885275007163 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 885275007164 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 885275007165 Walker A/P-loop; other site 885275007166 ATP binding site [chemical binding]; other site 885275007167 Q-loop/lid; other site 885275007168 ABC transporter signature motif; other site 885275007169 Walker B; other site 885275007170 D-loop; other site 885275007171 H-loop/switch region; other site 885275007172 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 885275007173 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 885275007174 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 885275007175 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275007176 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275007177 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 885275007178 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 885275007179 DNA binding site [nucleotide binding] 885275007180 active site 885275007181 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 885275007182 ApbE family; Region: ApbE; pfam02424 885275007183 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 885275007184 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 885275007185 trimer interface [polypeptide binding]; other site 885275007186 eyelet of channel; other site 885275007187 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 885275007188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275007189 ATP binding site [chemical binding]; other site 885275007190 G-X-G motif; other site 885275007191 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 885275007192 putative binding surface; other site 885275007193 active site 885275007194 transcriptional regulator RcsB; Provisional; Region: PRK10840 885275007195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275007196 active site 885275007197 phosphorylation site [posttranslational modification] 885275007198 intermolecular recognition site; other site 885275007199 dimerization interface [polypeptide binding]; other site 885275007200 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885275007201 DNA binding residues [nucleotide binding] 885275007202 dimerization interface [polypeptide binding]; other site 885275007203 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 885275007204 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885275007205 dimer interface [polypeptide binding]; other site 885275007206 phosphorylation site [posttranslational modification] 885275007207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275007208 ATP binding site [chemical binding]; other site 885275007209 Mg2+ binding site [ion binding]; other site 885275007210 G-X-G motif; other site 885275007211 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 885275007212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275007213 active site 885275007214 phosphorylation site [posttranslational modification] 885275007215 intermolecular recognition site; other site 885275007216 dimerization interface [polypeptide binding]; other site 885275007217 sensory histidine kinase AtoS; Provisional; Region: PRK11360 885275007218 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 885275007219 putative active site [active] 885275007220 heme pocket [chemical binding]; other site 885275007221 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885275007222 dimer interface [polypeptide binding]; other site 885275007223 phosphorylation site [posttranslational modification] 885275007224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275007225 ATP binding site [chemical binding]; other site 885275007226 Mg2+ binding site [ion binding]; other site 885275007227 G-X-G motif; other site 885275007228 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 885275007229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275007230 active site 885275007231 phosphorylation site [posttranslational modification] 885275007232 intermolecular recognition site; other site 885275007233 dimerization interface [polypeptide binding]; other site 885275007234 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275007235 Walker A motif; other site 885275007236 ATP binding site [chemical binding]; other site 885275007237 Walker B motif; other site 885275007238 arginine finger; other site 885275007239 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 885275007240 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920 885275007241 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 885275007242 Short chain fatty acid transporter; Region: SCFA_trans; pfam02667 885275007243 putative acyltransferase; Provisional; Region: PRK05790 885275007244 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 885275007245 dimer interface [polypeptide binding]; other site 885275007246 active site 885275007247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 885275007248 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 885275007249 Predicted secreted protein [Function unknown]; Region: COG5445 885275007250 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 885275007251 Predicted secreted protein [Function unknown]; Region: COG5445 885275007252 Stage II sporulation protein; Region: SpoIID; pfam08486 885275007253 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 885275007254 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 885275007255 MG2 domain; Region: A2M_N; pfam01835 885275007256 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 885275007257 Alpha-2-macroglobulin family; Region: A2M; pfam00207 885275007258 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 885275007259 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 885275007260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 885275007261 DNA gyrase subunit A; Validated; Region: PRK05560 885275007262 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 885275007263 CAP-like domain; other site 885275007264 active site 885275007265 primary dimer interface [polypeptide binding]; other site 885275007266 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 885275007267 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 885275007268 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 885275007269 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 885275007270 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 885275007271 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 885275007272 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 885275007273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275007274 S-adenosylmethionine binding site [chemical binding]; other site 885275007275 adhesin; Provisional; Region: PRK09752 885275007276 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 885275007277 Autotransporter beta-domain; Region: Autotransporter; pfam03797 885275007278 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 885275007279 ATP cone domain; Region: ATP-cone; pfam03477 885275007280 Class I ribonucleotide reductase; Region: RNR_I; cd01679 885275007281 active site 885275007282 dimer interface [polypeptide binding]; other site 885275007283 catalytic residues [active] 885275007284 effector binding site; other site 885275007285 R2 peptide binding site; other site 885275007286 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 885275007287 dimer interface [polypeptide binding]; other site 885275007288 putative radical transfer pathway; other site 885275007289 diiron center [ion binding]; other site 885275007290 tyrosyl radical; other site 885275007291 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 885275007292 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 885275007293 catalytic loop [active] 885275007294 iron binding site [ion binding]; other site 885275007295 hypothetical protein; Provisional; Region: PRK09902 885275007296 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 885275007297 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 885275007298 active site 885275007299 catalytic site [active] 885275007300 metal binding site [ion binding]; metal-binding site 885275007301 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 885275007302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275007303 putative substrate translocation pore; other site 885275007304 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 885275007305 hydroxyglutarate oxidase; Provisional; Region: PRK11728 885275007306 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 885275007307 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 885275007308 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 885275007309 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 885275007310 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 885275007311 Cysteine-rich domain; Region: CCG; pfam02754 885275007312 Cysteine-rich domain; Region: CCG; pfam02754 885275007313 hypothetical protein; Provisional; Region: PRK09956 885275007314 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 885275007315 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 885275007316 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 885275007317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275007318 putative substrate translocation pore; other site 885275007319 L-rhamnonate dehydratase; Provisional; Region: PRK15440 885275007320 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 885275007321 putative active site pocket [active] 885275007322 putative metal binding site [ion binding]; other site 885275007323 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 885275007324 Transcriptional regulator [Transcription]; Region: IclR; COG1414 885275007325 Bacterial transcriptional regulator; Region: IclR; pfam01614 885275007326 hypothetical protein; Provisional; Region: PRK03673 885275007327 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 885275007328 putative MPT binding site; other site 885275007329 Competence-damaged protein; Region: CinA; cl00666 885275007330 YfaZ precursor; Region: YfaZ; pfam07437 885275007331 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 885275007332 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 885275007333 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 885275007334 catalytic core [active] 885275007335 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 885275007336 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 885275007337 inhibitor-cofactor binding pocket; inhibition site 885275007338 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275007339 catalytic residue [active] 885275007340 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 885275007341 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 885275007342 Ligand binding site; other site 885275007343 Putative Catalytic site; other site 885275007344 DXD motif; other site 885275007345 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 885275007346 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 885275007347 substrate binding site [chemical binding]; other site 885275007348 cosubstrate binding site; other site 885275007349 catalytic site [active] 885275007350 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 885275007351 active site 885275007352 hexamer interface [polypeptide binding]; other site 885275007353 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 885275007354 NAD binding site [chemical binding]; other site 885275007355 substrate binding site [chemical binding]; other site 885275007356 active site 885275007357 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 885275007358 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 885275007359 putative active site [active] 885275007360 putative catalytic site [active] 885275007361 putative Zn binding site [ion binding]; other site 885275007362 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 885275007363 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 885275007364 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 885275007365 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 885275007366 signal transduction protein PmrD; Provisional; Region: PRK15450 885275007367 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 885275007368 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 885275007369 acyl-activating enzyme (AAE) consensus motif; other site 885275007370 putative AMP binding site [chemical binding]; other site 885275007371 putative active site [active] 885275007372 putative CoA binding site [chemical binding]; other site 885275007373 O-succinylbenzoate synthase; Provisional; Region: PRK05105 885275007374 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 885275007375 active site 885275007376 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 885275007377 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 885275007378 substrate binding site [chemical binding]; other site 885275007379 oxyanion hole (OAH) forming residues; other site 885275007380 trimer interface [polypeptide binding]; other site 885275007381 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 885275007382 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 885275007383 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 885275007384 dimer interface [polypeptide binding]; other site 885275007385 tetramer interface [polypeptide binding]; other site 885275007386 PYR/PP interface [polypeptide binding]; other site 885275007387 TPP binding site [chemical binding]; other site 885275007388 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 885275007389 TPP-binding site; other site 885275007390 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 885275007391 isochorismate synthases; Region: isochor_syn; TIGR00543 885275007392 hypothetical protein; Provisional; Region: PRK10404 885275007393 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 885275007394 Coenzyme A binding pocket [chemical binding]; other site 885275007395 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 885275007396 von Willebrand factor; Region: vWF_A; pfam12450 885275007397 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 885275007398 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 885275007399 metal ion-dependent adhesion site (MIDAS); other site 885275007400 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 885275007401 M28 Zn-Peptidases; Region: M28_like_1; cd05640 885275007402 Peptidase family M28; Region: Peptidase_M28; pfam04389 885275007403 metal binding site [ion binding]; metal-binding site 885275007404 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 885275007405 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 885275007406 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 885275007407 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 885275007408 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 885275007409 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 885275007410 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 885275007411 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 885275007412 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 885275007413 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 885275007414 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 885275007415 4Fe-4S binding domain; Region: Fer4; pfam00037 885275007416 4Fe-4S binding domain; Region: Fer4; pfam00037 885275007417 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 885275007418 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 885275007419 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 885275007420 catalytic loop [active] 885275007421 iron binding site [ion binding]; other site 885275007422 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 885275007423 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 885275007424 [4Fe-4S] binding site [ion binding]; other site 885275007425 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 885275007426 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 885275007427 SLBB domain; Region: SLBB; pfam10531 885275007428 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 885275007429 NADH dehydrogenase subunit E; Validated; Region: PRK07539 885275007430 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 885275007431 putative dimer interface [polypeptide binding]; other site 885275007432 [2Fe-2S] cluster binding site [ion binding]; other site 885275007433 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 885275007434 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 885275007435 NADH dehydrogenase subunit D; Validated; Region: PRK06075 885275007436 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 885275007437 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 885275007438 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 885275007439 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275007440 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 885275007441 putative dimerization interface [polypeptide binding]; other site 885275007442 aminotransferase AlaT; Validated; Region: PRK09265 885275007443 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 885275007444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275007445 homodimer interface [polypeptide binding]; other site 885275007446 catalytic residue [active] 885275007447 5'-nucleotidase; Provisional; Region: PRK03826 885275007448 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 885275007449 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 885275007450 TrkA-C domain; Region: TrkA_C; pfam02080 885275007451 TrkA-C domain; Region: TrkA_C; pfam02080 885275007452 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 885275007453 putative phosphatase; Provisional; Region: PRK11587 885275007454 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885275007455 motif II; other site 885275007456 hypothetical protein; Validated; Region: PRK05445 885275007457 hypothetical protein; Provisional; Region: PRK01816 885275007458 propionate/acetate kinase; Provisional; Region: PRK12379 885275007459 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 885275007460 phosphate acetyltransferase; Reviewed; Region: PRK05632 885275007461 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 885275007462 DRTGG domain; Region: DRTGG; pfam07085 885275007463 phosphate acetyltransferase; Region: pta; TIGR00651 885275007464 hypothetical protein; Provisional; Region: PRK11588 885275007465 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 885275007466 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 885275007467 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 885275007468 nudix motif; other site 885275007469 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 885275007470 active site 885275007471 metal binding site [ion binding]; metal-binding site 885275007472 homotetramer interface [polypeptide binding]; other site 885275007473 glutathione S-transferase; Provisional; Region: PRK15113 885275007474 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 885275007475 C-terminal domain interface [polypeptide binding]; other site 885275007476 GSH binding site (G-site) [chemical binding]; other site 885275007477 dimer interface [polypeptide binding]; other site 885275007478 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 885275007479 N-terminal domain interface [polypeptide binding]; other site 885275007480 putative dimer interface [polypeptide binding]; other site 885275007481 putative substrate binding pocket (H-site) [chemical binding]; other site 885275007482 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 885275007483 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 885275007484 C-terminal domain interface [polypeptide binding]; other site 885275007485 GSH binding site (G-site) [chemical binding]; other site 885275007486 dimer interface [polypeptide binding]; other site 885275007487 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 885275007488 N-terminal domain interface [polypeptide binding]; other site 885275007489 putative dimer interface [polypeptide binding]; other site 885275007490 active site 885275007491 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 885275007492 homooctamer interface [polypeptide binding]; other site 885275007493 active site 885275007494 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 885275007495 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 885275007496 putative NAD(P) binding site [chemical binding]; other site 885275007497 putative active site [active] 885275007498 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 885275007499 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 885275007500 Walker A/P-loop; other site 885275007501 ATP binding site [chemical binding]; other site 885275007502 Q-loop/lid; other site 885275007503 ABC transporter signature motif; other site 885275007504 Walker B; other site 885275007505 D-loop; other site 885275007506 H-loop/switch region; other site 885275007507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275007508 dimer interface [polypeptide binding]; other site 885275007509 conserved gate region; other site 885275007510 putative PBP binding loops; other site 885275007511 ABC-ATPase subunit interface; other site 885275007512 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 885275007513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275007514 dimer interface [polypeptide binding]; other site 885275007515 conserved gate region; other site 885275007516 putative PBP binding loops; other site 885275007517 ABC-ATPase subunit interface; other site 885275007518 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 885275007519 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 885275007520 substrate binding pocket [chemical binding]; other site 885275007521 membrane-bound complex binding site; other site 885275007522 hinge residues; other site 885275007523 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 885275007524 Flavoprotein; Region: Flavoprotein; pfam02441 885275007525 amidophosphoribosyltransferase; Provisional; Region: PRK09246 885275007526 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 885275007527 active site 885275007528 tetramer interface [polypeptide binding]; other site 885275007529 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 885275007530 active site 885275007531 colicin V production protein; Provisional; Region: PRK10845 885275007532 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 885275007533 cell division protein DedD; Provisional; Region: PRK11633 885275007534 Sporulation related domain; Region: SPOR; pfam05036 885275007535 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 885275007536 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 885275007537 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 885275007538 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 885275007539 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 885275007540 hypothetical protein; Provisional; Region: PRK10847 885275007541 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 885275007542 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 885275007543 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 885275007544 dimerization interface 3.5A [polypeptide binding]; other site 885275007545 active site 885275007546 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 885275007547 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 885275007548 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 885275007549 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 885275007550 ligand binding site [chemical binding]; other site 885275007551 NAD binding site [chemical binding]; other site 885275007552 catalytic site [active] 885275007553 homodimer interface [polypeptide binding]; other site 885275007554 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 885275007555 putative transporter; Provisional; Region: PRK12382 885275007556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275007557 putative substrate translocation pore; other site 885275007558 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 885275007559 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 885275007560 dimer interface [polypeptide binding]; other site 885275007561 active site 885275007562 Uncharacterized conserved protein [Function unknown]; Region: COG4121 885275007563 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 885275007564 YfcL protein; Region: YfcL; pfam08891 885275007565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 885275007566 hypothetical protein; Provisional; Region: PRK10621 885275007567 Predicted permeases [General function prediction only]; Region: COG0730 885275007568 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 885275007569 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 885275007570 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 885275007571 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 885275007572 Tetramer interface [polypeptide binding]; other site 885275007573 active site 885275007574 FMN-binding site [chemical binding]; other site 885275007575 HemK family putative methylases; Region: hemK_fam; TIGR00536 885275007576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275007577 S-adenosylmethionine binding site [chemical binding]; other site 885275007578 hypothetical protein; Provisional; Region: PRK04946 885275007579 Smr domain; Region: Smr; pfam01713 885275007580 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 885275007581 Fimbrial protein; Region: Fimbrial; cl01416 885275007582 Fimbrial protein; Region: Fimbrial; cl01416 885275007583 Fimbrial protein; Region: Fimbrial; cl01416 885275007584 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 885275007585 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 885275007586 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 885275007587 PapC N-terminal domain; Region: PapC_N; pfam13954 885275007588 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 885275007589 PapC C-terminal domain; Region: PapC_C; pfam13953 885275007590 Fimbrial protein; Region: Fimbrial; cl01416 885275007591 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 885275007592 catalytic core [active] 885275007593 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 885275007594 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 885275007595 substrate binding site [chemical binding]; other site 885275007596 oxyanion hole (OAH) forming residues; other site 885275007597 trimer interface [polypeptide binding]; other site 885275007598 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 885275007599 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 885275007600 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 885275007601 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 885275007602 dimer interface [polypeptide binding]; other site 885275007603 active site 885275007604 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 885275007605 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 885275007606 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 885275007607 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 885275007608 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 885275007609 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 885275007610 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 885275007611 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 885275007612 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 885275007613 Autotransporter beta-domain; Region: Autotransporter; pfam03797 885275007614 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 885275007615 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885275007616 DNA binding residues [nucleotide binding] 885275007617 dimerization interface [polypeptide binding]; other site 885275007618 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 885275007619 active site 885275007620 DNA binding site [nucleotide binding] 885275007621 Int/Topo IB signature motif; other site 885275007622 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 885275007623 active site 885275007624 DNA binding site [nucleotide binding] 885275007625 Int/Topo IB signature motif; other site 885275007626 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 885275007627 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275007628 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 885275007629 dimerization interface [polypeptide binding]; other site 885275007630 substrate binding pocket [chemical binding]; other site 885275007631 permease DsdX; Provisional; Region: PRK09921 885275007632 gluconate transporter; Region: gntP; TIGR00791 885275007633 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 885275007634 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 885275007635 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 885275007636 catalytic residue [active] 885275007637 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 885275007638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275007639 putative substrate translocation pore; other site 885275007640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275007641 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 885275007642 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885275007643 HlyD family secretion protein; Region: HlyD_3; pfam13437 885275007644 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 885275007645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275007646 active site 885275007647 phosphorylation site [posttranslational modification] 885275007648 intermolecular recognition site; other site 885275007649 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885275007650 DNA binding residues [nucleotide binding] 885275007651 dimerization interface [polypeptide binding]; other site 885275007652 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 885275007653 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 885275007654 substrate binding pocket [chemical binding]; other site 885275007655 membrane-bound complex binding site; other site 885275007656 hinge residues; other site 885275007657 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 885275007658 substrate binding pocket [chemical binding]; other site 885275007659 membrane-bound complex binding site; other site 885275007660 hinge residues; other site 885275007661 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885275007662 dimer interface [polypeptide binding]; other site 885275007663 phosphorylation site [posttranslational modification] 885275007664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275007665 ATP binding site [chemical binding]; other site 885275007666 Mg2+ binding site [ion binding]; other site 885275007667 G-X-G motif; other site 885275007668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275007669 active site 885275007670 phosphorylation site [posttranslational modification] 885275007671 intermolecular recognition site; other site 885275007672 dimerization interface [polypeptide binding]; other site 885275007673 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 885275007674 putative binding surface; other site 885275007675 active site 885275007676 putative CoA-transferase; Provisional; Region: PRK11430 885275007677 CoA-transferase family III; Region: CoA_transf_3; pfam02515 885275007678 putative transporter YfdV; Provisional; Region: PRK09903 885275007679 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 885275007680 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 885275007681 PYR/PP interface [polypeptide binding]; other site 885275007682 dimer interface [polypeptide binding]; other site 885275007683 TPP binding site [chemical binding]; other site 885275007684 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 885275007685 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 885275007686 TPP-binding site; other site 885275007687 dimer interface [polypeptide binding]; other site 885275007688 formyl-coenzyme A transferase; Provisional; Region: PRK05398 885275007689 CoA-transferase family III; Region: CoA_transf_3; pfam02515 885275007690 hypothetical protein; Provisional; Region: PRK10316 885275007691 YfdX protein; Region: YfdX; pfam10938 885275007692 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 885275007693 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 885275007694 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 885275007695 putative acyl-acceptor binding pocket; other site 885275007696 aminotransferase; Validated; Region: PRK08175 885275007697 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 885275007698 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275007699 homodimer interface [polypeptide binding]; other site 885275007700 catalytic residue [active] 885275007701 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 885275007702 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 885275007703 GAF domain; Region: GAF; cl17456 885275007704 Histidine kinase; Region: His_kinase; pfam06580 885275007705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275007706 ATP binding site [chemical binding]; other site 885275007707 Mg2+ binding site [ion binding]; other site 885275007708 G-X-G motif; other site 885275007709 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 885275007710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275007711 active site 885275007712 phosphorylation site [posttranslational modification] 885275007713 intermolecular recognition site; other site 885275007714 dimerization interface [polypeptide binding]; other site 885275007715 LytTr DNA-binding domain; Region: LytTR; pfam04397 885275007716 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 885275007717 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275007718 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 885275007719 dimerization domain swap beta strand [polypeptide binding]; other site 885275007720 regulatory protein interface [polypeptide binding]; other site 885275007721 active site 885275007722 regulatory phosphorylation site [posttranslational modification]; other site 885275007723 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 885275007724 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 885275007725 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 885275007726 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 885275007727 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 885275007728 active site 885275007729 phosphorylation site [posttranslational modification] 885275007730 exoaminopeptidase; Provisional; Region: PRK09961 885275007731 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 885275007732 oligomer interface [polypeptide binding]; other site 885275007733 active site 885275007734 metal binding site [ion binding]; metal-binding site 885275007735 aminopeptidase; Provisional; Region: PRK09795 885275007736 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 885275007737 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 885275007738 active site 885275007739 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 885275007740 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 885275007741 active site 885275007742 P-loop; other site 885275007743 phosphorylation site [posttranslational modification] 885275007744 glucokinase, proteobacterial type; Region: glk; TIGR00749 885275007745 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 885275007746 nucleotide binding site [chemical binding]; other site 885275007747 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 885275007748 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 885275007749 Cl- selectivity filter; other site 885275007750 Cl- binding residues [ion binding]; other site 885275007751 pore gating glutamate residue; other site 885275007752 dimer interface [polypeptide binding]; other site 885275007753 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 885275007754 manganese transport protein MntH; Reviewed; Region: PRK00701 885275007755 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 885275007756 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 885275007757 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 885275007758 Nucleoside recognition; Region: Gate; pfam07670 885275007759 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 885275007760 MASE1; Region: MASE1; pfam05231 885275007761 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 885275007762 diguanylate cyclase; Region: GGDEF; smart00267 885275007763 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885275007764 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 885275007765 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 885275007766 salt bridge; other site 885275007767 non-specific DNA binding site [nucleotide binding]; other site 885275007768 sequence-specific DNA binding site [nucleotide binding]; other site 885275007769 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 885275007770 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 885275007771 active site 885275007772 HIGH motif; other site 885275007773 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 885275007774 active site 885275007775 KMSKS motif; other site 885275007776 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 885275007777 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275007778 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 885275007779 putative dimerization interface [polypeptide binding]; other site 885275007780 putative substrate binding pocket [chemical binding]; other site 885275007781 XapX domain; Region: XapX; TIGR03510 885275007782 nucleoside transporter; Region: 2A0110; TIGR00889 885275007783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275007784 putative substrate translocation pore; other site 885275007785 purine nucleoside phosphorylase; Provisional; Region: PRK08202 885275007786 hypothetical protein; Provisional; Region: PRK11528 885275007787 Transcriptional regulator [Transcription]; Region: LysR; COG0583 885275007788 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275007789 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 885275007790 putative dimerization interface [polypeptide binding]; other site 885275007791 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 885275007792 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 885275007793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 885275007794 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 885275007795 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 885275007796 nucleotide binding pocket [chemical binding]; other site 885275007797 K-X-D-G motif; other site 885275007798 catalytic site [active] 885275007799 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 885275007800 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 885275007801 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 885275007802 Dimer interface [polypeptide binding]; other site 885275007803 BRCT sequence motif; other site 885275007804 cell division protein ZipA; Provisional; Region: PRK03427 885275007805 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 885275007806 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 885275007807 FtsZ protein binding site [polypeptide binding]; other site 885275007808 putative sulfate transport protein CysZ; Validated; Region: PRK04949 885275007809 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 885275007810 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 885275007811 dimer interface [polypeptide binding]; other site 885275007812 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275007813 catalytic residue [active] 885275007814 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 885275007815 dimerization domain swap beta strand [polypeptide binding]; other site 885275007816 regulatory protein interface [polypeptide binding]; other site 885275007817 active site 885275007818 regulatory phosphorylation site [posttranslational modification]; other site 885275007819 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 885275007820 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 885275007821 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 885275007822 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 885275007823 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 885275007824 HPr interaction site; other site 885275007825 glycerol kinase (GK) interaction site [polypeptide binding]; other site 885275007826 active site 885275007827 phosphorylation site [posttranslational modification] 885275007828 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 885275007829 dimer interface [polypeptide binding]; other site 885275007830 pyridoxamine kinase; Validated; Region: PRK05756 885275007831 pyridoxal binding site [chemical binding]; other site 885275007832 ATP binding site [chemical binding]; other site 885275007833 hypothetical protein; Provisional; Region: PRK10318 885275007834 cysteine synthase B; Region: cysM; TIGR01138 885275007835 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 885275007836 dimer interface [polypeptide binding]; other site 885275007837 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275007838 catalytic residue [active] 885275007839 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 885275007840 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 885275007841 Walker A/P-loop; other site 885275007842 ATP binding site [chemical binding]; other site 885275007843 Q-loop/lid; other site 885275007844 ABC transporter signature motif; other site 885275007845 Walker B; other site 885275007846 D-loop; other site 885275007847 H-loop/switch region; other site 885275007848 TOBE-like domain; Region: TOBE_3; pfam12857 885275007849 sulfate transport protein; Provisional; Region: cysT; CHL00187 885275007850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275007851 dimer interface [polypeptide binding]; other site 885275007852 conserved gate region; other site 885275007853 putative PBP binding loops; other site 885275007854 ABC-ATPase subunit interface; other site 885275007855 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 885275007856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275007857 dimer interface [polypeptide binding]; other site 885275007858 conserved gate region; other site 885275007859 putative PBP binding loops; other site 885275007860 ABC-ATPase subunit interface; other site 885275007861 thiosulfate transporter subunit; Provisional; Region: PRK10852 885275007862 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 885275007863 short chain dehydrogenase; Provisional; Region: PRK08226 885275007864 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 885275007865 NAD binding site [chemical binding]; other site 885275007866 homotetramer interface [polypeptide binding]; other site 885275007867 homodimer interface [polypeptide binding]; other site 885275007868 active site 885275007869 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 885275007870 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 885275007871 putative active site [active] 885275007872 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 885275007873 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 885275007874 active site turn [active] 885275007875 phosphorylation site [posttranslational modification] 885275007876 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 885275007877 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 885275007878 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 885275007879 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 885275007880 putative acetyltransferase; Provisional; Region: PRK03624 885275007881 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 885275007882 Coenzyme A binding pocket [chemical binding]; other site 885275007883 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 885275007884 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 885275007885 active site 885275007886 metal binding site [ion binding]; metal-binding site 885275007887 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 885275007888 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 885275007889 transcriptional regulator EutR; Provisional; Region: PRK10130 885275007890 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275007891 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275007892 carboxysome structural protein EutK; Provisional; Region: PRK15466 885275007893 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 885275007894 Hexamer interface [polypeptide binding]; other site 885275007895 Hexagonal pore residue; other site 885275007896 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 885275007897 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 885275007898 putative hexamer interface [polypeptide binding]; other site 885275007899 putative hexagonal pore; other site 885275007900 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 885275007901 putative hexamer interface [polypeptide binding]; other site 885275007902 putative hexagonal pore; other site 885275007903 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 885275007904 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 885275007905 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 885275007906 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 885275007907 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 885275007908 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 885275007909 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 885275007910 active site 885275007911 metal binding site [ion binding]; metal-binding site 885275007912 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 885275007913 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 885275007914 nucleotide binding site [chemical binding]; other site 885275007915 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 885275007916 putative catalytic cysteine [active] 885275007917 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 885275007918 Hexamer/Pentamer interface [polypeptide binding]; other site 885275007919 central pore; other site 885275007920 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 885275007921 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 885275007922 Hexamer interface [polypeptide binding]; other site 885275007923 Hexagonal pore residue; other site 885275007924 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 885275007925 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 885275007926 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 885275007927 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 885275007928 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 885275007929 G1 box; other site 885275007930 GTP/Mg2+ binding site [chemical binding]; other site 885275007931 G2 box; other site 885275007932 Switch I region; other site 885275007933 G3 box; other site 885275007934 Switch II region; other site 885275007935 G4 box; other site 885275007936 G5 box; other site 885275007937 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 885275007938 putative hexamer interface [polypeptide binding]; other site 885275007939 putative hexagonal pore; other site 885275007940 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 885275007941 Malic enzyme, N-terminal domain; Region: malic; pfam00390 885275007942 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 885275007943 putative NAD(P) binding site [chemical binding]; other site 885275007944 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 885275007945 transaldolase-like protein; Provisional; Region: PTZ00411 885275007946 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 885275007947 active site 885275007948 dimer interface [polypeptide binding]; other site 885275007949 catalytic residue [active] 885275007950 transketolase; Reviewed; Region: PRK12753 885275007951 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 885275007952 TPP-binding site [chemical binding]; other site 885275007953 dimer interface [polypeptide binding]; other site 885275007954 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 885275007955 PYR/PP interface [polypeptide binding]; other site 885275007956 dimer interface [polypeptide binding]; other site 885275007957 TPP binding site [chemical binding]; other site 885275007958 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 885275007959 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 885275007960 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 885275007961 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 885275007962 dimer interface [polypeptide binding]; other site 885275007963 ADP-ribose binding site [chemical binding]; other site 885275007964 active site 885275007965 nudix motif; other site 885275007966 metal binding site [ion binding]; metal-binding site 885275007967 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 885275007968 4Fe-4S binding domain; Region: Fer4; pfam00037 885275007969 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 885275007970 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 885275007971 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 885275007972 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 885275007973 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 885275007974 dimerization interface [polypeptide binding]; other site 885275007975 Histidine kinase; Region: HisKA_3; pfam07730 885275007976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275007977 ATP binding site [chemical binding]; other site 885275007978 Mg2+ binding site [ion binding]; other site 885275007979 G-X-G motif; other site 885275007980 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 885275007981 Protein export membrane protein; Region: SecD_SecF; cl14618 885275007982 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 885275007983 ArsC family; Region: ArsC; pfam03960 885275007984 putative catalytic residues [active] 885275007985 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 885275007986 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 885275007987 metal binding site [ion binding]; metal-binding site 885275007988 dimer interface [polypeptide binding]; other site 885275007989 hypothetical protein; Provisional; Region: PRK13664 885275007990 putative hydrolase; Provisional; Region: PRK11460 885275007991 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 885275007992 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 885275007993 Helicase; Region: Helicase_RecD; pfam05127 885275007994 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 885275007995 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 885275007996 Predicted metalloprotease [General function prediction only]; Region: COG2321 885275007997 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 885275007998 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 885275007999 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 885275008000 ATP binding site [chemical binding]; other site 885275008001 active site 885275008002 substrate binding site [chemical binding]; other site 885275008003 lipoprotein; Provisional; Region: PRK11679 885275008004 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 885275008005 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 885275008006 dihydrodipicolinate synthase; Region: dapA; TIGR00674 885275008007 dimer interface [polypeptide binding]; other site 885275008008 active site 885275008009 catalytic residue [active] 885275008010 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 885275008011 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 885275008012 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 885275008013 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 885275008014 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 885275008015 catalytic triad [active] 885275008016 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 885275008017 Domain of unknown function DUF20; Region: UPF0118; pfam01594 885275008018 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 885275008019 Peptidase family M48; Region: Peptidase_M48; cl12018 885275008020 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 885275008021 ArsC family; Region: ArsC; pfam03960 885275008022 catalytic residues [active] 885275008023 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 885275008024 DNA replication initiation factor; Provisional; Region: PRK08084 885275008025 uracil transporter; Provisional; Region: PRK10720 885275008026 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 885275008027 active site 885275008028 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 885275008029 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 885275008030 dimerization interface [polypeptide binding]; other site 885275008031 putative ATP binding site [chemical binding]; other site 885275008032 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 885275008033 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 885275008034 active site 885275008035 substrate binding site [chemical binding]; other site 885275008036 cosubstrate binding site; other site 885275008037 catalytic site [active] 885275008038 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 885275008039 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 885275008040 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 885275008041 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 885275008042 domain interface [polypeptide binding]; other site 885275008043 active site 885275008044 catalytic site [active] 885275008045 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 885275008046 putative active site [active] 885275008047 catalytic site [active] 885275008048 exopolyphosphatase; Provisional; Region: PRK10854 885275008049 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 885275008050 MASE1; Region: MASE1; pfam05231 885275008051 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 885275008052 diguanylate cyclase; Region: GGDEF; smart00267 885275008053 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885275008054 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 885275008055 GMP synthase; Reviewed; Region: guaA; PRK00074 885275008056 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 885275008057 AMP/PPi binding site [chemical binding]; other site 885275008058 candidate oxyanion hole; other site 885275008059 catalytic triad [active] 885275008060 potential glutamine specificity residues [chemical binding]; other site 885275008061 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 885275008062 ATP Binding subdomain [chemical binding]; other site 885275008063 Ligand Binding sites [chemical binding]; other site 885275008064 Dimerization subdomain; other site 885275008065 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 885275008066 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 885275008067 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 885275008068 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 885275008069 active site 885275008070 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 885275008071 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 885275008072 generic binding surface II; other site 885275008073 generic binding surface I; other site 885275008074 RatA-like protein; Provisional; Region: PRK15316 885275008075 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 885275008076 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 885275008077 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 885275008078 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 885275008079 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 885275008080 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 885275008081 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 885275008082 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 885275008083 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 885275008084 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 885275008085 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 885275008086 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 885275008087 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 885275008088 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 885275008089 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 885275008090 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 885275008091 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 885275008092 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 885275008093 intimin-like protein SinH; Provisional; Region: PRK15318 885275008094 intimin-like protein SinH; Provisional; Region: PRK15318 885275008095 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 885275008096 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 885275008097 GTP-binding protein Der; Reviewed; Region: PRK00093 885275008098 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 885275008099 G1 box; other site 885275008100 GTP/Mg2+ binding site [chemical binding]; other site 885275008101 Switch I region; other site 885275008102 G2 box; other site 885275008103 Switch II region; other site 885275008104 G3 box; other site 885275008105 G4 box; other site 885275008106 G5 box; other site 885275008107 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 885275008108 G1 box; other site 885275008109 GTP/Mg2+ binding site [chemical binding]; other site 885275008110 Switch I region; other site 885275008111 G2 box; other site 885275008112 G3 box; other site 885275008113 Switch II region; other site 885275008114 G4 box; other site 885275008115 G5 box; other site 885275008116 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 885275008117 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 885275008118 Trp docking motif [polypeptide binding]; other site 885275008119 active site 885275008120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 885275008121 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 885275008122 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 885275008123 dimer interface [polypeptide binding]; other site 885275008124 motif 1; other site 885275008125 active site 885275008126 motif 2; other site 885275008127 motif 3; other site 885275008128 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 885275008129 anticodon binding site; other site 885275008130 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 885275008131 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 885275008132 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 885275008133 cytoskeletal protein RodZ; Provisional; Region: PRK10856 885275008134 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 885275008135 non-specific DNA binding site [nucleotide binding]; other site 885275008136 salt bridge; other site 885275008137 sequence-specific DNA binding site [nucleotide binding]; other site 885275008138 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 885275008139 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 885275008140 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885275008141 FeS/SAM binding site; other site 885275008142 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 885275008143 active site 885275008144 multimer interface [polypeptide binding]; other site 885275008145 penicillin-binding protein 1C; Provisional; Region: PRK11240 885275008146 Transglycosylase; Region: Transgly; pfam00912 885275008147 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 885275008148 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 885275008149 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 885275008150 MG2 domain; Region: A2M_N; pfam01835 885275008151 Alpha-2-macroglobulin family; Region: A2M; pfam00207 885275008152 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 885275008153 surface patch; other site 885275008154 thioester region; other site 885275008155 specificity defining residues; other site 885275008156 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 885275008157 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 885275008158 active site residue [active] 885275008159 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 885275008160 active site residue [active] 885275008161 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 885275008162 aminopeptidase B; Provisional; Region: PRK05015 885275008163 Peptidase; Region: DUF3663; pfam12404 885275008164 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 885275008165 interface (dimer of trimers) [polypeptide binding]; other site 885275008166 Substrate-binding/catalytic site; other site 885275008167 Zn-binding sites [ion binding]; other site 885275008168 hypothetical protein; Provisional; Region: PRK10721 885275008169 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 885275008170 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 885275008171 catalytic loop [active] 885275008172 iron binding site [ion binding]; other site 885275008173 chaperone protein HscA; Provisional; Region: hscA; PRK05183 885275008174 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 885275008175 nucleotide binding site [chemical binding]; other site 885275008176 putative NEF/HSP70 interaction site [polypeptide binding]; other site 885275008177 SBD interface [polypeptide binding]; other site 885275008178 co-chaperone HscB; Provisional; Region: hscB; PRK05014 885275008179 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 885275008180 HSP70 interaction site [polypeptide binding]; other site 885275008181 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 885275008182 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 885275008183 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 885275008184 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 885275008185 trimerization site [polypeptide binding]; other site 885275008186 active site 885275008187 cysteine desulfurase; Provisional; Region: PRK14012 885275008188 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 885275008189 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 885275008190 catalytic residue [active] 885275008191 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 885275008192 Rrf2 family protein; Region: rrf2_super; TIGR00738 885275008193 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 885275008194 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 885275008195 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 885275008196 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 885275008197 active site 885275008198 dimerization interface [polypeptide binding]; other site 885275008199 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 885275008200 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 885275008201 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 885275008202 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 885275008203 PRD domain; Region: PRD; pfam00874 885275008204 PRD domain; Region: PRD; pfam00874 885275008205 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 885275008206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275008207 putative substrate translocation pore; other site 885275008208 Predicted membrane protein [Function unknown]; Region: COG2259 885275008209 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 885275008210 active site 885275008211 catalytic residues [active] 885275008212 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 885275008213 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 885275008214 putative NAD(P) binding site [chemical binding]; other site 885275008215 catalytic Zn binding site [ion binding]; other site 885275008216 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 885275008217 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 885275008218 TM-ABC transporter signature motif; other site 885275008219 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 885275008220 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 885275008221 Walker A/P-loop; other site 885275008222 ATP binding site [chemical binding]; other site 885275008223 Q-loop/lid; other site 885275008224 ABC transporter signature motif; other site 885275008225 Walker B; other site 885275008226 D-loop; other site 885275008227 H-loop/switch region; other site 885275008228 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 885275008229 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 885275008230 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 885275008231 ligand binding site [chemical binding]; other site 885275008232 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 885275008233 TPR motif; other site 885275008234 binding surface 885275008235 TPR repeat; Region: TPR_11; pfam13414 885275008236 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 885275008237 TPR motif; other site 885275008238 binding surface 885275008239 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 885275008240 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 885275008241 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 885275008242 nucleotide binding site [chemical binding]; other site 885275008243 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 885275008244 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 885275008245 dimer interface [polypeptide binding]; other site 885275008246 active site 885275008247 glycine-pyridoxal phosphate binding site [chemical binding]; other site 885275008248 folate binding site [chemical binding]; other site 885275008249 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 885275008250 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 885275008251 heme-binding site [chemical binding]; other site 885275008252 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 885275008253 FAD binding pocket [chemical binding]; other site 885275008254 FAD binding motif [chemical binding]; other site 885275008255 phosphate binding motif [ion binding]; other site 885275008256 beta-alpha-beta structure motif; other site 885275008257 NAD binding pocket [chemical binding]; other site 885275008258 Heme binding pocket [chemical binding]; other site 885275008259 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 885275008260 Nitrogen regulatory protein P-II; Region: P-II; smart00938 885275008261 response regulator GlrR; Provisional; Region: PRK15115 885275008262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275008263 active site 885275008264 phosphorylation site [posttranslational modification] 885275008265 intermolecular recognition site; other site 885275008266 dimerization interface [polypeptide binding]; other site 885275008267 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275008268 Walker A motif; other site 885275008269 ATP binding site [chemical binding]; other site 885275008270 Walker B motif; other site 885275008271 arginine finger; other site 885275008272 hypothetical protein; Provisional; Region: PRK10722 885275008273 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 885275008274 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885275008275 dimer interface [polypeptide binding]; other site 885275008276 phosphorylation site [posttranslational modification] 885275008277 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275008278 ATP binding site [chemical binding]; other site 885275008279 Mg2+ binding site [ion binding]; other site 885275008280 G-X-G motif; other site 885275008281 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 885275008282 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 885275008283 dimerization interface [polypeptide binding]; other site 885275008284 ATP binding site [chemical binding]; other site 885275008285 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 885275008286 dimerization interface [polypeptide binding]; other site 885275008287 ATP binding site [chemical binding]; other site 885275008288 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 885275008289 putative active site [active] 885275008290 catalytic triad [active] 885275008291 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 885275008292 nucleoside/Zn binding site; other site 885275008293 dimer interface [polypeptide binding]; other site 885275008294 catalytic motif [active] 885275008295 hypothetical protein; Provisional; Region: PRK11590 885275008296 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 885275008297 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 885275008298 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 885275008299 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 885275008300 putative active site [active] 885275008301 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 885275008302 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 885275008303 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 885275008304 active site 885275008305 hydrophilic channel; other site 885275008306 dimerization interface [polypeptide binding]; other site 885275008307 catalytic residues [active] 885275008308 active site lid [active] 885275008309 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 885275008310 Recombination protein O N terminal; Region: RecO_N; pfam11967 885275008311 Recombination protein O C terminal; Region: RecO_C; pfam02565 885275008312 GTPase Era; Reviewed; Region: era; PRK00089 885275008313 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 885275008314 G1 box; other site 885275008315 GTP/Mg2+ binding site [chemical binding]; other site 885275008316 Switch I region; other site 885275008317 G2 box; other site 885275008318 Switch II region; other site 885275008319 G3 box; other site 885275008320 G4 box; other site 885275008321 G5 box; other site 885275008322 KH domain; Region: KH_2; pfam07650 885275008323 ribonuclease III; Reviewed; Region: rnc; PRK00102 885275008324 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 885275008325 dimerization interface [polypeptide binding]; other site 885275008326 active site 885275008327 metal binding site [ion binding]; metal-binding site 885275008328 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 885275008329 dsRNA binding site [nucleotide binding]; other site 885275008330 signal peptidase I; Provisional; Region: PRK10861 885275008331 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 885275008332 Catalytic site [active] 885275008333 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 885275008334 GTP-binding protein LepA; Provisional; Region: PRK05433 885275008335 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 885275008336 G1 box; other site 885275008337 putative GEF interaction site [polypeptide binding]; other site 885275008338 GTP/Mg2+ binding site [chemical binding]; other site 885275008339 Switch I region; other site 885275008340 G2 box; other site 885275008341 G3 box; other site 885275008342 Switch II region; other site 885275008343 G4 box; other site 885275008344 G5 box; other site 885275008345 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 885275008346 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 885275008347 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 885275008348 SoxR reducing system protein RseC; Provisional; Region: PRK10862 885275008349 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 885275008350 anti-sigma E factor; Provisional; Region: rseB; PRK09455 885275008351 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 885275008352 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 885275008353 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 885275008354 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 885275008355 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 885275008356 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 885275008357 DNA binding residues [nucleotide binding] 885275008358 L-aspartate oxidase; Provisional; Region: PRK09077 885275008359 L-aspartate oxidase; Provisional; Region: PRK06175 885275008360 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 885275008361 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 885275008362 Methyltransferase domain; Region: Methyltransf_26; pfam13659 885275008363 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 885275008364 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 885275008365 ATP binding site [chemical binding]; other site 885275008366 Mg++ binding site [ion binding]; other site 885275008367 motif III; other site 885275008368 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 885275008369 nucleotide binding region [chemical binding]; other site 885275008370 ATP-binding site [chemical binding]; other site 885275008371 Transcriptional regulator [Transcription]; Region: LysR; COG0583 885275008372 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275008373 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 885275008374 dimerization interface [polypeptide binding]; other site 885275008375 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 885275008376 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 885275008377 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 885275008378 ligand binding site [chemical binding]; other site 885275008379 active site 885275008380 UGI interface [polypeptide binding]; other site 885275008381 catalytic site [active] 885275008382 putative methyltransferase; Provisional; Region: PRK10864 885275008383 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 885275008384 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 885275008385 thioredoxin 2; Provisional; Region: PRK10996 885275008386 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 885275008387 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 885275008388 catalytic residues [active] 885275008389 Uncharacterized conserved protein [Function unknown]; Region: COG3148 885275008390 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 885275008391 CoA binding domain; Region: CoA_binding_2; pfam13380 885275008392 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 885275008393 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 885275008394 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 885275008395 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 885275008396 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 885275008397 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 885275008398 domain interface [polypeptide binding]; other site 885275008399 putative active site [active] 885275008400 catalytic site [active] 885275008401 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 885275008402 domain interface [polypeptide binding]; other site 885275008403 putative active site [active] 885275008404 catalytic site [active] 885275008405 lipoprotein; Provisional; Region: PRK10759 885275008406 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 885275008407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275008408 putative substrate translocation pore; other site 885275008409 protein disaggregation chaperone; Provisional; Region: PRK10865 885275008410 Clp amino terminal domain; Region: Clp_N; pfam02861 885275008411 Clp amino terminal domain; Region: Clp_N; pfam02861 885275008412 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275008413 Walker A motif; other site 885275008414 ATP binding site [chemical binding]; other site 885275008415 Walker B motif; other site 885275008416 arginine finger; other site 885275008417 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275008418 Walker A motif; other site 885275008419 ATP binding site [chemical binding]; other site 885275008420 Walker B motif; other site 885275008421 arginine finger; other site 885275008422 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 885275008423 hypothetical protein; Provisional; Region: PRK10723 885275008424 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 885275008425 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 885275008426 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 885275008427 RNA binding surface [nucleotide binding]; other site 885275008428 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 885275008429 active site 885275008430 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 885275008431 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 885275008432 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 885275008433 30S subunit binding site; other site 885275008434 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 885275008435 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 885275008436 Prephenate dehydratase; Region: PDT; pfam00800 885275008437 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 885275008438 putative L-Phe binding site [chemical binding]; other site 885275008439 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 885275008440 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 885275008441 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 885275008442 prephenate dehydrogenase; Validated; Region: PRK08507 885275008443 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 885275008444 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 885275008445 lipoprotein; Provisional; Region: PRK11443 885275008446 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 885275008447 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 885275008448 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 885275008449 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885275008450 metal binding site [ion binding]; metal-binding site 885275008451 active site 885275008452 I-site; other site 885275008453 putative outer membrane lipoprotein; Provisional; Region: PRK09967 885275008454 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 885275008455 ligand binding site [chemical binding]; other site 885275008456 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 885275008457 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 885275008458 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 885275008459 RimM N-terminal domain; Region: RimM; pfam01782 885275008460 PRC-barrel domain; Region: PRC; pfam05239 885275008461 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 885275008462 signal recognition particle protein; Provisional; Region: PRK10867 885275008463 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 885275008464 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 885275008465 P loop; other site 885275008466 GTP binding site [chemical binding]; other site 885275008467 Signal peptide binding domain; Region: SRP_SPB; pfam02978 885275008468 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 885275008469 hypothetical protein; Provisional; Region: PRK11573 885275008470 Domain of unknown function DUF21; Region: DUF21; pfam01595 885275008471 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 885275008472 Transporter associated domain; Region: CorC_HlyC; smart01091 885275008473 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 885275008474 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 885275008475 dimer interface [polypeptide binding]; other site 885275008476 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 885275008477 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 885275008478 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 885275008479 recombination and repair protein; Provisional; Region: PRK10869 885275008480 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 885275008481 Walker A/P-loop; other site 885275008482 ATP binding site [chemical binding]; other site 885275008483 Q-loop/lid; other site 885275008484 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 885275008485 Q-loop/lid; other site 885275008486 ABC transporter signature motif; other site 885275008487 Walker B; other site 885275008488 D-loop; other site 885275008489 H-loop/switch region; other site 885275008490 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 885275008491 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 885275008492 hypothetical protein; Validated; Region: PRK01777 885275008493 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 885275008494 putative coenzyme Q binding site [chemical binding]; other site 885275008495 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 885275008496 SmpB-tmRNA interface; other site 885275008497 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 885275008498 substrate binding pocket [chemical binding]; other site 885275008499 active site 885275008500 iron coordination sites [ion binding]; other site 885275008501 Predicted dehydrogenase [General function prediction only]; Region: COG0579 885275008502 hydroxyglutarate oxidase; Provisional; Region: PRK11728 885275008503 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 885275008504 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 885275008505 tetramerization interface [polypeptide binding]; other site 885275008506 NAD(P) binding site [chemical binding]; other site 885275008507 catalytic residues [active] 885275008508 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 885275008509 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 885275008510 inhibitor-cofactor binding pocket; inhibition site 885275008511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275008512 catalytic residue [active] 885275008513 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 885275008514 TMPIT-like protein; Region: TMPIT; pfam07851 885275008515 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 885275008516 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885275008517 DNA-binding site [nucleotide binding]; DNA binding site 885275008518 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 885275008519 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 885275008520 bacterial OsmY and nodulation domain; Region: BON; smart00749 885275008521 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 885275008522 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 885275008523 dimerization interface [polypeptide binding]; other site 885275008524 putative DNA binding site [nucleotide binding]; other site 885275008525 putative Zn2+ binding site [ion binding]; other site 885275008526 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 885275008527 active site residue [active] 885275008528 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 885275008529 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 885275008530 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 885275008531 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 885275008532 hypothetical protein; Provisional; Region: PRK10556 885275008533 hypothetical protein; Provisional; Region: PRK10132 885275008534 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 885275008535 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885275008536 DNA-binding site [nucleotide binding]; DNA binding site 885275008537 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 885275008538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275008539 homodimer interface [polypeptide binding]; other site 885275008540 catalytic residue [active] 885275008541 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 885275008542 Uncharacterized conserved protein [Function unknown]; Region: COG2128 885275008543 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 885275008544 catalytic residues [active] 885275008545 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 885275008546 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 885275008547 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 885275008548 Class I ribonucleotide reductase; Region: RNR_I; cd01679 885275008549 active site 885275008550 dimer interface [polypeptide binding]; other site 885275008551 catalytic residues [active] 885275008552 effector binding site; other site 885275008553 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 885275008554 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 885275008555 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 885275008556 dimer interface [polypeptide binding]; other site 885275008557 putative radical transfer pathway; other site 885275008558 diiron center [ion binding]; other site 885275008559 tyrosyl radical; other site 885275008560 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 885275008561 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 885275008562 Walker A/P-loop; other site 885275008563 ATP binding site [chemical binding]; other site 885275008564 Q-loop/lid; other site 885275008565 ABC transporter signature motif; other site 885275008566 Walker B; other site 885275008567 D-loop; other site 885275008568 H-loop/switch region; other site 885275008569 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 885275008570 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 885275008571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275008572 dimer interface [polypeptide binding]; other site 885275008573 conserved gate region; other site 885275008574 putative PBP binding loops; other site 885275008575 ABC-ATPase subunit interface; other site 885275008576 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 885275008577 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 885275008578 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 885275008579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275008580 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 885275008581 putative L-valine exporter; Provisional; Region: PRK10408 885275008582 transcriptional repressor MprA; Provisional; Region: PRK10870 885275008583 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 885275008584 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 885275008585 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885275008586 HlyD family secretion protein; Region: HlyD_3; pfam13437 885275008587 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 885275008588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275008589 putative substrate translocation pore; other site 885275008590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275008591 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 885275008592 Zn2+ binding site [ion binding]; other site 885275008593 Mg2+ binding site [ion binding]; other site 885275008594 AAA domain; Region: AAA_33; pfam13671 885275008595 S-ribosylhomocysteinase; Provisional; Region: PRK02260 885275008596 glutamate--cysteine ligase; Provisional; Region: PRK02107 885275008597 Predicted membrane protein [Function unknown]; Region: COG1238 885275008598 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 885275008599 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885275008600 motif II; other site 885275008601 carbon storage regulator; Provisional; Region: PRK01712 885275008602 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 885275008603 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 885275008604 motif 1; other site 885275008605 active site 885275008606 motif 2; other site 885275008607 motif 3; other site 885275008608 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 885275008609 DHHA1 domain; Region: DHHA1; pfam02272 885275008610 recombination regulator RecX; Reviewed; Region: recX; PRK00117 885275008611 recombinase A; Provisional; Region: recA; PRK09354 885275008612 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 885275008613 hexamer interface [polypeptide binding]; other site 885275008614 Walker A motif; other site 885275008615 ATP binding site [chemical binding]; other site 885275008616 Walker B motif; other site 885275008617 hypothetical protein; Validated; Region: PRK03661 885275008618 Transglycosylase SLT domain; Region: SLT_2; pfam13406 885275008619 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 885275008620 N-acetyl-D-glucosamine binding site [chemical binding]; other site 885275008621 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 885275008622 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 885275008623 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 885275008624 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 885275008625 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 885275008626 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 885275008627 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 885275008628 putative NAD(P) binding site [chemical binding]; other site 885275008629 active site 885275008630 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 885275008631 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 885275008632 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 885275008633 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 885275008634 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 885275008635 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 885275008636 putative active site [active] 885275008637 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 885275008638 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 885275008639 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 885275008640 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275008641 Walker A motif; other site 885275008642 ATP binding site [chemical binding]; other site 885275008643 Walker B motif; other site 885275008644 arginine finger; other site 885275008645 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 885275008646 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 885275008647 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 885275008648 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 885275008649 iron binding site [ion binding]; other site 885275008650 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 885275008651 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 885275008652 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 885275008653 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 885275008654 Acylphosphatase; Region: Acylphosphatase; pfam00708 885275008655 HypF finger; Region: zf-HYPF; pfam07503 885275008656 HypF finger; Region: zf-HYPF; pfam07503 885275008657 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 885275008658 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 885275008659 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 885275008660 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 885275008661 non-specific DNA binding site [nucleotide binding]; other site 885275008662 salt bridge; other site 885275008663 sequence-specific DNA binding site [nucleotide binding]; other site 885275008664 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 885275008665 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 885275008666 nickel binding site [ion binding]; other site 885275008667 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 885275008668 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 885275008669 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 885275008670 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 885275008671 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 885275008672 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 885275008673 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 885275008674 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 885275008675 NADH dehydrogenase; Region: NADHdh; cl00469 885275008676 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 885275008677 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 885275008678 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 885275008679 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 885275008680 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 885275008681 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 885275008682 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 885275008683 hydrogenase assembly chaperone; Provisional; Region: PRK10409 885275008684 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 885275008685 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 885275008686 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 885275008687 dimerization interface [polypeptide binding]; other site 885275008688 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 885275008689 ATP binding site [chemical binding]; other site 885275008690 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 885275008691 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 885275008692 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 885275008693 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275008694 Walker A motif; other site 885275008695 ATP binding site [chemical binding]; other site 885275008696 Walker B motif; other site 885275008697 arginine finger; other site 885275008698 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 885275008699 molybdenum-pterin binding domain; Region: Mop; TIGR00638 885275008700 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 885275008701 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 885275008702 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 885275008703 MutS domain I; Region: MutS_I; pfam01624 885275008704 MutS domain II; Region: MutS_II; pfam05188 885275008705 MutS domain III; Region: MutS_III; pfam05192 885275008706 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 885275008707 Walker A/P-loop; other site 885275008708 ATP binding site [chemical binding]; other site 885275008709 Q-loop/lid; other site 885275008710 ABC transporter signature motif; other site 885275008711 Walker B; other site 885275008712 D-loop; other site 885275008713 H-loop/switch region; other site 885275008714 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 885275008715 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 885275008716 active site 885275008717 metal binding site [ion binding]; metal-binding site 885275008718 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 885275008719 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 885275008720 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 885275008721 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 885275008722 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 885275008723 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 885275008724 putative aldolase; Validated; Region: PRK08130 885275008725 active site 885275008726 intersubunit interface [polypeptide binding]; other site 885275008727 Zn2+ binding site [ion binding]; other site 885275008728 hypothetical protein; Provisional; Region: PRK09989 885275008729 putative transporter; Provisional; Region: PRK09821 885275008730 GntP family permease; Region: GntP_permease; pfam02447 885275008731 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 885275008732 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 885275008733 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 885275008734 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 885275008735 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 885275008736 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 885275008737 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 885275008738 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 885275008739 DNA binding residues [nucleotide binding] 885275008740 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 885275008741 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 885275008742 Peptidase family M23; Region: Peptidase_M23; pfam01551 885275008743 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 885275008744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275008745 S-adenosylmethionine binding site [chemical binding]; other site 885275008746 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 885275008747 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 885275008748 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 885275008749 Permutation of conserved domain; other site 885275008750 active site 885275008751 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 885275008752 homotrimer interaction site [polypeptide binding]; other site 885275008753 zinc binding site [ion binding]; other site 885275008754 CDP-binding sites; other site 885275008755 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 885275008756 substrate binding site; other site 885275008757 dimer interface; other site 885275008758 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 885275008759 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 885275008760 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 885275008761 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 885275008762 ligand-binding site [chemical binding]; other site 885275008763 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 885275008764 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 885275008765 CysD dimerization site [polypeptide binding]; other site 885275008766 G1 box; other site 885275008767 putative GEF interaction site [polypeptide binding]; other site 885275008768 GTP/Mg2+ binding site [chemical binding]; other site 885275008769 Switch I region; other site 885275008770 G2 box; other site 885275008771 G3 box; other site 885275008772 Switch II region; other site 885275008773 G4 box; other site 885275008774 G5 box; other site 885275008775 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 885275008776 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 885275008777 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 885275008778 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 885275008779 Active Sites [active] 885275008780 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 885275008781 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 885275008782 metal binding site [ion binding]; metal-binding site 885275008783 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 885275008784 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 885275008785 Active Sites [active] 885275008786 sulfite reductase subunit beta; Provisional; Region: PRK13504 885275008787 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 885275008788 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 885275008789 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 885275008790 Flavodoxin; Region: Flavodoxin_1; pfam00258 885275008791 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 885275008792 FAD binding pocket [chemical binding]; other site 885275008793 FAD binding motif [chemical binding]; other site 885275008794 catalytic residues [active] 885275008795 NAD binding pocket [chemical binding]; other site 885275008796 phosphate binding motif [ion binding]; other site 885275008797 beta-alpha-beta structure motif; other site 885275008798 6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470 885275008799 homohexamer interface [polypeptide binding]; other site 885275008800 putative substrate stabilizing pore; other site 885275008801 pterin binding site; other site 885275008802 FAD dependent oxidoreductase; Region: DAO; pfam01266 885275008803 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 885275008804 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 885275008805 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 885275008806 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 885275008807 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 885275008808 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 885275008809 Ligand binding site [chemical binding]; other site 885275008810 Electron transfer flavoprotein domain; Region: ETF; pfam01012 885275008811 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 885275008812 benzoate transport; Region: 2A0115; TIGR00895 885275008813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275008814 putative substrate translocation pore; other site 885275008815 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 885275008816 FAD binding domain; Region: FAD_binding_4; pfam01565 885275008817 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 885275008818 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 885275008819 NADP binding site [chemical binding]; other site 885275008820 homodimer interface [polypeptide binding]; other site 885275008821 active site 885275008822 Major Facilitator Superfamily; Region: MFS_1; pfam07690 885275008823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275008824 putative substrate translocation pore; other site 885275008825 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 885275008826 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 885275008827 nucleotide binding site [chemical binding]; other site 885275008828 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 885275008829 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 885275008830 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 885275008831 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 885275008832 Repair protein; Region: Repair_PSII; pfam04536 885275008833 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 885275008834 Repair protein; Region: Repair_PSII; pfam04536 885275008835 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 885275008836 Repair protein; Region: Repair_PSII; pfam04536 885275008837 enolase; Provisional; Region: eno; PRK00077 885275008838 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 885275008839 dimer interface [polypeptide binding]; other site 885275008840 metal binding site [ion binding]; metal-binding site 885275008841 substrate binding pocket [chemical binding]; other site 885275008842 CTP synthetase; Validated; Region: pyrG; PRK05380 885275008843 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 885275008844 Catalytic site [active] 885275008845 active site 885275008846 UTP binding site [chemical binding]; other site 885275008847 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 885275008848 active site 885275008849 putative oxyanion hole; other site 885275008850 catalytic triad [active] 885275008851 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 885275008852 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 885275008853 homodimer interface [polypeptide binding]; other site 885275008854 metal binding site [ion binding]; metal-binding site 885275008855 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 885275008856 homodimer interface [polypeptide binding]; other site 885275008857 active site 885275008858 putative chemical substrate binding site [chemical binding]; other site 885275008859 metal binding site [ion binding]; metal-binding site 885275008860 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 885275008861 HD domain; Region: HD_4; pfam13328 885275008862 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 885275008863 synthetase active site [active] 885275008864 NTP binding site [chemical binding]; other site 885275008865 metal binding site [ion binding]; metal-binding site 885275008866 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 885275008867 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 885275008868 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 885275008869 TRAM domain; Region: TRAM; pfam01938 885275008870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275008871 S-adenosylmethionine binding site [chemical binding]; other site 885275008872 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 885275008873 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 885275008874 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 885275008875 dimerization interface [polypeptide binding]; other site 885275008876 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885275008877 dimer interface [polypeptide binding]; other site 885275008878 phosphorylation site [posttranslational modification] 885275008879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275008880 ATP binding site [chemical binding]; other site 885275008881 Mg2+ binding site [ion binding]; other site 885275008882 G-X-G motif; other site 885275008883 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 885275008884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275008885 active site 885275008886 phosphorylation site [posttranslational modification] 885275008887 intermolecular recognition site; other site 885275008888 dimerization interface [polypeptide binding]; other site 885275008889 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 885275008890 putative binding surface; other site 885275008891 active site 885275008892 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 885275008893 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 885275008894 active site 885275008895 tetramer interface [polypeptide binding]; other site 885275008896 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 885275008897 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 885275008898 active site 885275008899 tetramer interface [polypeptide binding]; other site 885275008900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275008901 D-galactonate transporter; Region: 2A0114; TIGR00893 885275008902 putative substrate translocation pore; other site 885275008903 flavodoxin; Provisional; Region: PRK08105 885275008904 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 885275008905 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 885275008906 probable active site [active] 885275008907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 885275008908 SecY interacting protein Syd; Provisional; Region: PRK04968 885275008909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 885275008910 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 885275008911 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 885275008912 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 885275008913 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 885275008914 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 885275008915 serine transporter; Region: stp; TIGR00814 885275008916 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 885275008917 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 885275008918 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 885275008919 flap endonuclease-like protein; Provisional; Region: PRK09482 885275008920 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 885275008921 active site 885275008922 metal binding site 1 [ion binding]; metal-binding site 885275008923 putative 5' ssDNA interaction site; other site 885275008924 metal binding site 3; metal-binding site 885275008925 metal binding site 2 [ion binding]; metal-binding site 885275008926 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 885275008927 putative DNA binding site [nucleotide binding]; other site 885275008928 putative metal binding site [ion binding]; other site 885275008929 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 885275008930 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 885275008931 dimer interface [polypeptide binding]; other site 885275008932 active site 885275008933 metal binding site [ion binding]; metal-binding site 885275008934 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 885275008935 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 885275008936 intersubunit interface [polypeptide binding]; other site 885275008937 active site 885275008938 Zn2+ binding site [ion binding]; other site 885275008939 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 885275008940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275008941 putative substrate translocation pore; other site 885275008942 L-fucose isomerase; Provisional; Region: fucI; PRK10991 885275008943 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 885275008944 hexamer (dimer of trimers) interface [polypeptide binding]; other site 885275008945 trimer interface [polypeptide binding]; other site 885275008946 substrate binding site [chemical binding]; other site 885275008947 Mn binding site [ion binding]; other site 885275008948 L-fuculokinase; Provisional; Region: PRK10331 885275008949 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 885275008950 nucleotide binding site [chemical binding]; other site 885275008951 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 885275008952 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 885275008953 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 885275008954 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 885275008955 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 885275008956 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 885275008957 hypothetical protein; Provisional; Region: PRK10873 885275008958 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 885275008959 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275008960 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 885275008961 dimerization interface [polypeptide binding]; other site 885275008962 substrate binding pocket [chemical binding]; other site 885275008963 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 885275008964 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 885275008965 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 885275008966 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 885275008967 catalytic residue [active] 885275008968 CsdA-binding activator; Provisional; Region: PRK15019 885275008969 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 885275008970 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 885275008971 putative ATP binding site [chemical binding]; other site 885275008972 putative substrate interface [chemical binding]; other site 885275008973 murein transglycosylase A; Provisional; Region: mltA; PRK11162 885275008974 MltA specific insert domain; Region: MltA; pfam03562 885275008975 3D domain; Region: 3D; pfam06725 885275008976 Protein of unknown function (DUF770); Region: DUF770; pfam05591 885275008977 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 885275008978 Protein of unknown function (DUF877); Region: DUF877; pfam05943 885275008979 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 885275008980 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 885275008981 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 885275008982 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 885275008983 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 885275008984 ligand binding site [chemical binding]; other site 885275008985 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 885275008986 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 885275008987 Clp amino terminal domain; Region: Clp_N; pfam02861 885275008988 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275008989 Walker A motif; other site 885275008990 ATP binding site [chemical binding]; other site 885275008991 Walker B motif; other site 885275008992 arginine finger; other site 885275008993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275008994 Walker A motif; other site 885275008995 ATP binding site [chemical binding]; other site 885275008996 Walker B motif; other site 885275008997 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 885275008998 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 885275008999 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 885275009000 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 885275009001 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 885275009002 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 885275009003 PAAR motif; Region: PAAR_motif; pfam05488 885275009004 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 885275009005 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 885275009006 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 885275009007 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 885275009008 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 885275009009 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 885275009010 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 885275009011 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 885275009012 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 885275009013 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 885275009014 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 885275009015 ImpA domain protein; Region: DUF3702; pfam12486 885275009016 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 885275009017 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 885275009018 putative ligand binding site [chemical binding]; other site 885275009019 putative NAD binding site [chemical binding]; other site 885275009020 catalytic site [active] 885275009021 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 885275009022 putative active site [active] 885275009023 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 885275009024 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 885275009025 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275009026 homodimer interface [polypeptide binding]; other site 885275009027 catalytic residue [active] 885275009028 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 885275009029 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 885275009030 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 885275009031 active site turn [active] 885275009032 phosphorylation site [posttranslational modification] 885275009033 CAT RNA binding domain; Region: CAT_RBD; pfam03123 885275009034 PRD domain; Region: PRD; pfam00874 885275009035 PRD domain; Region: PRD; pfam00874 885275009036 AMIN domain; Region: AMIN; pfam11741 885275009037 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 885275009038 active site 885275009039 metal binding site [ion binding]; metal-binding site 885275009040 N-acetylglutamate synthase; Validated; Region: PRK05279 885275009041 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 885275009042 putative feedback inhibition sensing region; other site 885275009043 putative nucleotide binding site [chemical binding]; other site 885275009044 putative substrate binding site [chemical binding]; other site 885275009045 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 885275009046 Coenzyme A binding pocket [chemical binding]; other site 885275009047 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 885275009048 AAA domain; Region: AAA_30; pfam13604 885275009049 Family description; Region: UvrD_C_2; pfam13538 885275009050 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 885275009051 protease3; Provisional; Region: PRK15101 885275009052 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 885275009053 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 885275009054 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 885275009055 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 885275009056 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 885275009057 hypothetical protein; Provisional; Region: PRK10332 885275009058 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 885275009059 hypothetical protein; Provisional; Region: PRK11521 885275009060 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 885275009061 hypothetical protein; Provisional; Region: PRK10557 885275009062 hypothetical protein; Provisional; Region: PRK10506 885275009063 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 885275009064 thymidylate synthase; Reviewed; Region: thyA; PRK01827 885275009065 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 885275009066 dimerization interface [polypeptide binding]; other site 885275009067 active site 885275009068 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 885275009069 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 885275009070 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 885275009071 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 885275009072 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 885275009073 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 885275009074 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 885275009075 putative active site [active] 885275009076 Ap4A binding site [chemical binding]; other site 885275009077 nudix motif; other site 885275009078 putative metal binding site [ion binding]; other site 885275009079 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 885275009080 putative DNA-binding cleft [nucleotide binding]; other site 885275009081 putative DNA clevage site; other site 885275009082 molecular lever; other site 885275009083 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 885275009084 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 885275009085 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 885275009086 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 885275009087 active site 885275009088 catalytic tetrad [active] 885275009089 lysophospholipid transporter LplT; Provisional; Region: PRK11195 885275009090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275009091 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 885275009092 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 885275009093 putative acyl-acceptor binding pocket; other site 885275009094 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 885275009095 acyl-activating enzyme (AAE) consensus motif; other site 885275009096 putative AMP binding site [chemical binding]; other site 885275009097 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 885275009098 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 885275009099 DNA binding site [nucleotide binding] 885275009100 domain linker motif; other site 885275009101 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 885275009102 dimerization interface (closed form) [polypeptide binding]; other site 885275009103 ligand binding site [chemical binding]; other site 885275009104 diaminopimelate decarboxylase; Provisional; Region: PRK11165 885275009105 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 885275009106 active site 885275009107 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 885275009108 substrate binding site [chemical binding]; other site 885275009109 catalytic residues [active] 885275009110 dimer interface [polypeptide binding]; other site 885275009111 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 885275009112 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275009113 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 885275009114 dimerization interface [polypeptide binding]; other site 885275009115 putative racemase; Provisional; Region: PRK10200 885275009116 aspartate racemase; Region: asp_race; TIGR00035 885275009117 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 885275009118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275009119 putative substrate translocation pore; other site 885275009120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275009121 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 885275009122 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 885275009123 NADP binding site [chemical binding]; other site 885275009124 homodimer interface [polypeptide binding]; other site 885275009125 active site 885275009126 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 885275009127 putative acyltransferase; Provisional; Region: PRK05790 885275009128 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 885275009129 dimer interface [polypeptide binding]; other site 885275009130 active site 885275009131 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 885275009132 serine transporter; Region: stp; TIGR00814 885275009133 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 885275009134 Peptidase family M23; Region: Peptidase_M23; pfam01551 885275009135 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 885275009136 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 885275009137 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 885275009138 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 885275009139 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 885275009140 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 885275009141 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 885275009142 catalytic loop [active] 885275009143 iron binding site [ion binding]; other site 885275009144 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 885275009145 GAF domain; Region: GAF; cl17456 885275009146 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 885275009147 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 885275009148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275009149 Walker A motif; other site 885275009150 ATP binding site [chemical binding]; other site 885275009151 Walker B motif; other site 885275009152 arginine finger; other site 885275009153 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 885275009154 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 885275009155 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 885275009156 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 885275009157 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 885275009158 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 885275009159 catalytic residue [active] 885275009160 peptidase; Reviewed; Region: PRK13004 885275009161 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 885275009162 putative metal binding site [ion binding]; other site 885275009163 putative dimer interface [polypeptide binding]; other site 885275009164 D-hydantoinase; Region: D-hydantoinase; TIGR02033 885275009165 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 885275009166 tetramer interface [polypeptide binding]; other site 885275009167 active site 885275009168 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 885275009169 carbamate kinase; Reviewed; Region: PRK12686 885275009170 putative substrate binding site [chemical binding]; other site 885275009171 homodimer interface [polypeptide binding]; other site 885275009172 nucleotide binding site [chemical binding]; other site 885275009173 nucleotide binding site [chemical binding]; other site 885275009174 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 885275009175 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 885275009176 XdhC Rossmann domain; Region: XdhC_C; pfam13478 885275009177 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 885275009178 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 885275009179 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 885275009180 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 885275009181 Ligand binding site; other site 885275009182 metal-binding site 885275009183 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 885275009184 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 885275009185 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 885275009186 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 885275009187 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 885275009188 active site 885275009189 putative substrate binding pocket [chemical binding]; other site 885275009190 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 885275009191 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 885275009192 putative hypoxanthine oxidase; Provisional; Region: PRK09800 885275009193 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 885275009194 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 885275009195 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 885275009196 uracil-xanthine permease; Region: ncs2; TIGR00801 885275009197 guanine deaminase; Provisional; Region: PRK09228 885275009198 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 885275009199 active site 885275009200 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 885275009201 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 885275009202 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 885275009203 4Fe-4S binding domain; Region: Fer4; pfam00037 885275009204 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 885275009205 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 885275009206 xanthine permease; Region: pbuX; TIGR03173 885275009207 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 885275009208 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 885275009209 active site 885275009210 metal binding site [ion binding]; metal-binding site 885275009211 nudix motif; other site 885275009212 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 885275009213 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 885275009214 dimer interface [polypeptide binding]; other site 885275009215 putative anticodon binding site; other site 885275009216 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 885275009217 motif 1; other site 885275009218 active site 885275009219 motif 2; other site 885275009220 motif 3; other site 885275009221 peptide chain release factor 2; Provisional; Region: PRK08787 885275009222 This domain is found in peptide chain release factors; Region: PCRF; smart00937 885275009223 RF-1 domain; Region: RF-1; pfam00472 885275009224 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 885275009225 DHH family; Region: DHH; pfam01368 885275009226 DHHA1 domain; Region: DHHA1; pfam02272 885275009227 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 885275009228 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 885275009229 dimerization domain [polypeptide binding]; other site 885275009230 dimer interface [polypeptide binding]; other site 885275009231 catalytic residues [active] 885275009232 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 885275009233 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 885275009234 active site 885275009235 Int/Topo IB signature motif; other site 885275009236 flavodoxin FldB; Provisional; Region: PRK12359 885275009237 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 885275009238 hypothetical protein; Provisional; Region: PRK10878 885275009239 putative global regulator; Reviewed; Region: PRK09559 885275009240 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 885275009241 hemolysin; Provisional; Region: PRK15087 885275009242 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 885275009243 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 885275009244 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 885275009245 beta-galactosidase; Region: BGL; TIGR03356 885275009246 glycine dehydrogenase; Provisional; Region: PRK05367 885275009247 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 885275009248 tetramer interface [polypeptide binding]; other site 885275009249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275009250 catalytic residue [active] 885275009251 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 885275009252 tetramer interface [polypeptide binding]; other site 885275009253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275009254 catalytic residue [active] 885275009255 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 885275009256 lipoyl attachment site [posttranslational modification]; other site 885275009257 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 885275009258 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 885275009259 oxidoreductase; Provisional; Region: PRK08013 885275009260 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 885275009261 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 885275009262 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 885275009263 proline aminopeptidase P II; Provisional; Region: PRK10879 885275009264 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 885275009265 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 885275009266 active site 885275009267 hypothetical protein; Reviewed; Region: PRK01736 885275009268 Z-ring-associated protein; Provisional; Region: PRK10972 885275009269 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 885275009270 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 885275009271 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 885275009272 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 885275009273 ligand binding site [chemical binding]; other site 885275009274 NAD binding site [chemical binding]; other site 885275009275 tetramer interface [polypeptide binding]; other site 885275009276 catalytic site [active] 885275009277 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 885275009278 L-serine binding site [chemical binding]; other site 885275009279 ACT domain interface; other site 885275009280 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 885275009281 tetramer (dimer of dimers) interface [polypeptide binding]; other site 885275009282 active site 885275009283 dimer interface [polypeptide binding]; other site 885275009284 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 885275009285 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 885275009286 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275009287 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 885275009288 putative dimerization interface [polypeptide binding]; other site 885275009289 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 885275009290 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275009291 Transcriptional regulator [Transcription]; Region: LysR; COG0583 885275009292 Uncharacterized conserved protein [Function unknown]; Region: COG2968 885275009293 oxidative stress defense protein; Provisional; Region: PRK11087 885275009294 arginine exporter protein; Provisional; Region: PRK09304 885275009295 mechanosensitive channel MscS; Provisional; Region: PRK10334 885275009296 Mechanosensitive ion channel; Region: MS_channel; pfam00924 885275009297 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 885275009298 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 885275009299 active site 885275009300 intersubunit interface [polypeptide binding]; other site 885275009301 zinc binding site [ion binding]; other site 885275009302 Na+ binding site [ion binding]; other site 885275009303 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 885275009304 Phosphoglycerate kinase; Region: PGK; pfam00162 885275009305 substrate binding site [chemical binding]; other site 885275009306 hinge regions; other site 885275009307 ADP binding site [chemical binding]; other site 885275009308 catalytic site [active] 885275009309 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 885275009310 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 885275009311 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 885275009312 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 885275009313 trimer interface [polypeptide binding]; other site 885275009314 putative Zn binding site [ion binding]; other site 885275009315 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 885275009316 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 885275009317 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 885275009318 Walker A/P-loop; other site 885275009319 ATP binding site [chemical binding]; other site 885275009320 Q-loop/lid; other site 885275009321 ABC transporter signature motif; other site 885275009322 Walker B; other site 885275009323 D-loop; other site 885275009324 H-loop/switch region; other site 885275009325 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 885275009326 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 885275009327 Walker A/P-loop; other site 885275009328 ATP binding site [chemical binding]; other site 885275009329 Q-loop/lid; other site 885275009330 ABC transporter signature motif; other site 885275009331 Walker B; other site 885275009332 D-loop; other site 885275009333 H-loop/switch region; other site 885275009334 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 885275009335 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 885275009336 active site 885275009337 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 885275009338 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 885275009339 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 885275009340 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 885275009341 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 885275009342 putative NAD(P) binding site [chemical binding]; other site 885275009343 catalytic Zn binding site [ion binding]; other site 885275009344 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 885275009345 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 885275009346 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 885275009347 active site 885275009348 P-loop; other site 885275009349 phosphorylation site [posttranslational modification] 885275009350 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 885275009351 active site 885275009352 phosphorylation site [posttranslational modification] 885275009353 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 885275009354 SPFH domain / Band 7 family; Region: Band_7; pfam01145 885275009355 transketolase; Reviewed; Region: PRK12753 885275009356 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 885275009357 TPP-binding site [chemical binding]; other site 885275009358 dimer interface [polypeptide binding]; other site 885275009359 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 885275009360 PYR/PP interface [polypeptide binding]; other site 885275009361 dimer interface [polypeptide binding]; other site 885275009362 TPP binding site [chemical binding]; other site 885275009363 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 885275009364 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 885275009365 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 885275009366 agmatinase; Region: agmatinase; TIGR01230 885275009367 oligomer interface [polypeptide binding]; other site 885275009368 putative active site [active] 885275009369 Mn binding site [ion binding]; other site 885275009370 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 885275009371 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 885275009372 dimer interface [polypeptide binding]; other site 885275009373 active site 885275009374 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 885275009375 catalytic residues [active] 885275009376 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 885275009377 Virulence promoting factor; Region: YqgB; pfam11036 885275009378 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 885275009379 S-adenosylmethionine synthetase; Validated; Region: PRK05250 885275009380 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 885275009381 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 885275009382 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 885275009383 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 885275009384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275009385 putative substrate translocation pore; other site 885275009386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275009387 hypothetical protein; Provisional; Region: PRK04860 885275009388 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 885275009389 DNA-specific endonuclease I; Provisional; Region: PRK15137 885275009390 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 885275009391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 885275009392 RNA methyltransferase, RsmE family; Region: TIGR00046 885275009393 glutathione synthetase; Provisional; Region: PRK05246 885275009394 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 885275009395 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 885275009396 hypothetical protein; Validated; Region: PRK00228 885275009397 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 885275009398 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 885275009399 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 885275009400 Walker A motif; other site 885275009401 ATP binding site [chemical binding]; other site 885275009402 Walker B motif; other site 885275009403 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 885275009404 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 885275009405 catalytic residue [active] 885275009406 YGGT family; Region: YGGT; pfam02325 885275009407 YGGT family; Region: YGGT; pfam02325 885275009408 hypothetical protein; Validated; Region: PRK05090 885275009409 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 885275009410 active site 885275009411 dimerization interface [polypeptide binding]; other site 885275009412 HemN family oxidoreductase; Provisional; Region: PRK05660 885275009413 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885275009414 FeS/SAM binding site; other site 885275009415 HemN C-terminal domain; Region: HemN_C; pfam06969 885275009416 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 885275009417 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 885275009418 homodimer interface [polypeptide binding]; other site 885275009419 active site 885275009420 hypothetical protein; Provisional; Region: PRK10626 885275009421 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 885275009422 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 885275009423 hypothetical protein; Provisional; Region: PRK11702 885275009424 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 885275009425 adenine DNA glycosylase; Provisional; Region: PRK10880 885275009426 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 885275009427 minor groove reading motif; other site 885275009428 helix-hairpin-helix signature motif; other site 885275009429 substrate binding pocket [chemical binding]; other site 885275009430 active site 885275009431 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 885275009432 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 885275009433 DNA binding and oxoG recognition site [nucleotide binding] 885275009434 oxidative damage protection protein; Provisional; Region: PRK05408 885275009435 murein transglycosylase C; Provisional; Region: mltC; PRK11671 885275009436 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 885275009437 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 885275009438 N-acetyl-D-glucosamine binding site [chemical binding]; other site 885275009439 catalytic residue [active] 885275009440 nucleoside transporter; Region: 2A0110; TIGR00889 885275009441 ornithine decarboxylase; Provisional; Region: PRK13578 885275009442 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 885275009443 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 885275009444 homodimer interface [polypeptide binding]; other site 885275009445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275009446 catalytic residue [active] 885275009447 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 885275009448 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 885275009449 integrase; Provisional; Region: PRK09692 885275009450 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 885275009451 active site 885275009452 Int/Topo IB signature motif; other site 885275009453 DNA primase; Validated; Region: dnaG; PRK05667 885275009454 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 885275009455 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 885275009456 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 885275009457 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 885275009458 MarR family; Region: MarR_2; cl17246 885275009459 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 885275009460 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 885275009461 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 885275009462 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 885275009463 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 885275009464 Adhesin biosynthesis transcription regulatory protein; Region: PapB; cl04012 885275009465 FaeA-like protein; Region: FaeA; pfam04703 885275009466 Transposase; Region: DDE_Tnp_ISL3; pfam01610 885275009467 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 885275009468 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 885275009469 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 885275009470 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 885275009471 Protein of unknown function, DUF417; Region: DUF417; pfam04224 885275009472 IS2 repressor TnpA; Reviewed; Region: PRK09413 885275009473 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 885275009474 IS2 transposase TnpB; Reviewed; Region: PRK09409 885275009475 HTH-like domain; Region: HTH_21; pfam13276 885275009476 Integrase core domain; Region: rve; pfam00665 885275009477 Integrase core domain; Region: rve_3; pfam13683 885275009478 bifunctional enterobactin receptor/adhesin protein; Provisional; Region: PRK13486 885275009479 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885275009480 N-terminal plug; other site 885275009481 ligand-binding site [chemical binding]; other site 885275009482 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 885275009483 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 885275009484 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 885275009485 L-lactate permease; Region: Lactate_perm; cl00701 885275009486 Integrase core domain; Region: rve; pfam00665 885275009487 Integrase core domain; Region: rve_2; pfam13333 885275009488 potential frameshift: common BLAST hit: gi|317052798|ref|YP_004119564.1| Integrase catalytic region 885275009489 HTH-like domain; Region: HTH_21; pfam13276 885275009490 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 885275009491 Transposase; Region: HTH_Tnp_1; cl17663 885275009492 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 885275009493 putative transposase OrfB; Reviewed; Region: PHA02517 885275009494 Integrase core domain; Region: rve; pfam00665 885275009495 Integrase core domain; Region: rve_3; pfam13683 885275009496 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 885275009497 Helix-turn-helix domain; Region: HTH_38; pfam13936 885275009498 Integrase core domain; Region: rve; pfam00665 885275009499 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 885275009500 Transposase; Region: HTH_Tnp_1; pfam01527 885275009501 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 885275009502 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 885275009503 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 885275009504 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 885275009505 Autotransporter beta-domain; Region: Autotransporter; pfam03797 885275009506 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 885275009507 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885275009508 N-terminal plug; other site 885275009509 ligand-binding site [chemical binding]; other site 885275009510 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 885275009511 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 885275009512 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 885275009513 IucA / IucC family; Region: IucA_IucC; pfam04183 885275009514 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 885275009515 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 885275009516 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 885275009517 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 885275009518 IucA / IucC family; Region: IucA_IucC; pfam04183 885275009519 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 885275009520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275009521 Major Facilitator Superfamily; Region: MFS_1; pfam07690 885275009522 putative substrate translocation pore; other site 885275009523 IS2 transposase TnpB; Reviewed; Region: PRK09409 885275009524 HTH-like domain; Region: HTH_21; pfam13276 885275009525 Integrase core domain; Region: rve; pfam00665 885275009526 Integrase core domain; Region: rve_3; pfam13683 885275009527 IS2 repressor TnpA; Reviewed; Region: PRK09413 885275009528 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 885275009529 Domain of unknown function (DUF303); Region: DUF303; pfam03629 885275009530 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 885275009531 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 885275009532 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 885275009533 Kelch motif; Region: Kelch_1; pfam01344 885275009534 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 885275009535 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 885275009536 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 885275009537 putative sialic acid transporter; Provisional; Region: PRK03893 885275009538 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275009539 putative substrate translocation pore; other site 885275009540 N-acetylmannosamine kinase; Provisional; Region: PRK05082 885275009541 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 885275009542 nucleotide binding site [chemical binding]; other site 885275009543 N-acetylneuraminate lyase; Provisional; Region: PRK04147 885275009544 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 885275009545 inhibitor site; inhibition site 885275009546 active site 885275009547 dimer interface [polypeptide binding]; other site 885275009548 catalytic residue [active] 885275009549 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 885275009550 Transposase; Region: HTH_Tnp_1; pfam01527 885275009551 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 885275009552 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 885275009553 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 885275009554 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 885275009555 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 885275009556 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 885275009557 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 885275009558 homodimer interface [polypeptide binding]; other site 885275009559 putative GKAP docking site [polypeptide binding]; other site 885275009560 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 885275009561 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 885275009562 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 885275009563 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 885275009564 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 885275009565 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 885275009566 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 885275009567 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 885275009568 Reverse gyrase [DNA replication, recombination, and repair]; Region: COG1110 885275009569 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 885275009570 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 885275009571 Predicted GTPase [General function prediction only]; Region: COG3596 885275009572 YfjP GTPase; Region: YfjP; cd11383 885275009573 G1 box; other site 885275009574 GTP/Mg2+ binding site [chemical binding]; other site 885275009575 Switch I region; other site 885275009576 G2 box; other site 885275009577 Switch II region; other site 885275009578 G3 box; other site 885275009579 G4 box; other site 885275009580 G5 box; other site 885275009581 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 885275009582 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 885275009583 hypothetical protein; Provisional; Region: PRK09945 885275009584 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 885275009585 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 885275009586 Autotransporter beta-domain; Region: Autotransporter; smart00869 885275009587 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 885275009588 Domain of unknown function (DUF932); Region: DUF932; pfam06067 885275009589 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 885275009590 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 885275009591 MPN+ (JAMM) motif; other site 885275009592 Zinc-binding site [ion binding]; other site 885275009593 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 885275009594 Methyltransferase domain; Region: Methyltransf_27; pfam13708 885275009595 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 885275009596 KpsF/GutQ family protein; Region: kpsF; TIGR00393 885275009597 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 885275009598 putative active site [active] 885275009599 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 885275009600 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 885275009601 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 885275009602 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 885275009603 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 885275009604 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 885275009605 Ligand binding site; other site 885275009606 oligomer interface; other site 885275009607 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 885275009608 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 885275009609 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 885275009610 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 885275009611 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 885275009612 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 885275009613 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 885275009614 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 885275009615 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 885275009616 active site 885275009617 Integrase core domain; Region: rve; pfam00665 885275009618 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 885275009619 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 885275009620 Walker A/P-loop; other site 885275009621 ATP binding site [chemical binding]; other site 885275009622 Q-loop/lid; other site 885275009623 ABC transporter signature motif; other site 885275009624 Walker B; other site 885275009625 D-loop; other site 885275009626 H-loop/switch region; other site 885275009627 ABC-2 type transporter; Region: ABC2_membrane; cl17235 885275009628 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 885275009629 GspL-like protein; Provisional; Region: PRK09662 885275009630 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 885275009631 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 885275009632 type II secretion system protein J; Region: gspJ; TIGR01711 885275009633 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 885275009634 type II secretion system protein I; Region: gspI; TIGR01707 885275009635 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 885275009636 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 885275009637 Type II transport protein GspH; Region: GspH; pfam12019 885275009638 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 885275009639 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 885275009640 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 885275009641 type II secretion system protein F; Region: GspF; TIGR02120 885275009642 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 885275009643 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 885275009644 type II secretion system protein E; Region: type_II_gspE; TIGR02533 885275009645 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 885275009646 Walker A motif; other site 885275009647 ATP binding site [chemical binding]; other site 885275009648 Walker B motif; other site 885275009649 type II secretion system protein D; Region: type_II_gspD; TIGR02517 885275009650 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 885275009651 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 885275009652 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 885275009653 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 885275009654 putative type II secretion protein GspC; Provisional; Region: PRK09681 885275009655 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 885275009656 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 885275009657 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 885275009658 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 885275009659 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 885275009660 Domain of unknown function (DUF4092); Region: DUF4092; pfam13322 885275009661 Peptidase M60-like family; Region: M60-like; pfam13402 885275009662 glycolate transporter; Provisional; Region: PRK09695 885275009663 L-lactate permease; Region: Lactate_perm; cl00701 885275009664 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 885275009665 active site 885275009666 hypothetical protein; Provisional; Region: PRK09732 885275009667 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 885275009668 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 885275009669 Cysteine-rich domain; Region: CCG; pfam02754 885275009670 Cysteine-rich domain; Region: CCG; pfam02754 885275009671 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 885275009672 FAD binding domain; Region: FAD_binding_4; pfam01565 885275009673 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 885275009674 FAD binding domain; Region: FAD_binding_4; pfam01565 885275009675 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 885275009676 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885275009677 DNA-binding site [nucleotide binding]; DNA binding site 885275009678 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 885275009679 acyl-CoA synthetase; Validated; Region: PRK09192 885275009680 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 885275009681 acyl-activating enzyme (AAE) consensus motif; other site 885275009682 active site 885275009683 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 885275009684 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 885275009685 NAD(P) binding site [chemical binding]; other site 885275009686 active site 885275009687 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885275009688 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 885275009689 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 885275009690 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 885275009691 catalytic residue [active] 885275009692 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 885275009693 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 885275009694 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 885275009695 Predicted permeases [General function prediction only]; Region: COG0795 885275009696 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 885275009697 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 885275009698 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 885275009699 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 885275009700 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 885275009701 active site 885275009702 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 885275009703 TMP-binding site; other site 885275009704 ATP-binding site [chemical binding]; other site 885275009705 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 885275009706 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 885275009707 TMP-binding site; other site 885275009708 ATP-binding site [chemical binding]; other site 885275009709 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 885275009710 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 885275009711 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 885275009712 CHAP domain; Region: CHAP; pfam05257 885275009713 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 885275009714 putative S-transferase; Provisional; Region: PRK11752 885275009715 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 885275009716 C-terminal domain interface [polypeptide binding]; other site 885275009717 GSH binding site (G-site) [chemical binding]; other site 885275009718 dimer interface [polypeptide binding]; other site 885275009719 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 885275009720 dimer interface [polypeptide binding]; other site 885275009721 N-terminal domain interface [polypeptide binding]; other site 885275009722 active site 885275009723 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 885275009724 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 885275009725 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 885275009726 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 885275009727 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 885275009728 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 885275009729 putative substrate-binding site; other site 885275009730 nickel binding site [ion binding]; other site 885275009731 hydrogenase 2 large subunit; Provisional; Region: PRK10467 885275009732 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 885275009733 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 885275009734 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 885275009735 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 885275009736 4Fe-4S binding domain; Region: Fer4_6; pfam12837 885275009737 hydrogenase 2 small subunit; Provisional; Region: PRK10468 885275009738 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 885275009739 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 885275009740 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 885275009741 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 885275009742 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 885275009743 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 885275009744 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 885275009745 active site 885275009746 catalytic tetrad [active] 885275009747 hypothetical protein; Provisional; Region: PRK05208 885275009748 oxidoreductase; Provisional; Region: PRK07985 885275009749 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 885275009750 NAD binding site [chemical binding]; other site 885275009751 metal binding site [ion binding]; metal-binding site 885275009752 active site 885275009753 biopolymer transport protein ExbD; Provisional; Region: PRK11267 885275009754 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 885275009755 biopolymer transport protein ExbB; Provisional; Region: PRK10414 885275009756 cystathionine beta-lyase; Provisional; Region: PRK08114 885275009757 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 885275009758 homodimer interface [polypeptide binding]; other site 885275009759 substrate-cofactor binding pocket; other site 885275009760 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275009761 catalytic residue [active] 885275009762 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 885275009763 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 885275009764 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 885275009765 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 885275009766 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275009767 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275009768 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 885275009769 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 885275009770 dimer interface [polypeptide binding]; other site 885275009771 active site 885275009772 metal binding site [ion binding]; metal-binding site 885275009773 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 885275009774 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 885275009775 active site 885275009776 catalytic tetrad [active] 885275009777 putative outer membrane lipoprotein; Provisional; Region: PRK09973 885275009778 hypothetical protein; Provisional; Region: PRK01254 885275009779 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 885275009780 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 885275009781 Transcriptional regulators [Transcription]; Region: FadR; COG2186 885275009782 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885275009783 DNA-binding site [nucleotide binding]; DNA binding site 885275009784 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 885275009785 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 885275009786 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 885275009787 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 885275009788 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 885275009789 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 885275009790 putative NAD(P) binding site [chemical binding]; other site 885275009791 catalytic Zn binding site [ion binding]; other site 885275009792 structural Zn binding site [ion binding]; other site 885275009793 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 885275009794 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 885275009795 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 885275009796 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 885275009797 DctM-like transporters; Region: DctM; pfam06808 885275009798 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 885275009799 FtsI repressor; Provisional; Region: PRK10883 885275009800 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 885275009801 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 885275009802 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 885275009803 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 885275009804 putative acyl-acceptor binding pocket; other site 885275009805 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 885275009806 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 885275009807 CAP-like domain; other site 885275009808 active site 885275009809 primary dimer interface [polypeptide binding]; other site 885275009810 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 885275009811 putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755 885275009812 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 885275009813 peptide binding site [polypeptide binding]; other site 885275009814 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 885275009815 TIGR00156 family protein; Region: TIGR00156 885275009816 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 885275009817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275009818 active site 885275009819 phosphorylation site [posttranslational modification] 885275009820 intermolecular recognition site; other site 885275009821 dimerization interface [polypeptide binding]; other site 885275009822 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 885275009823 DNA binding site [nucleotide binding] 885275009824 sensor protein QseC; Provisional; Region: PRK10337 885275009825 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885275009826 dimer interface [polypeptide binding]; other site 885275009827 phosphorylation site [posttranslational modification] 885275009828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275009829 ATP binding site [chemical binding]; other site 885275009830 Mg2+ binding site [ion binding]; other site 885275009831 G-X-G motif; other site 885275009832 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 885275009833 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 885275009834 Uncharacterized conserved protein [Function unknown]; Region: COG1359 885275009835 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 885275009836 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 885275009837 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cd04795 885275009838 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 885275009839 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 885275009840 siderophore binding site; other site 885275009841 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 885275009842 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 885275009843 ABC-ATPase subunit interface; other site 885275009844 dimer interface [polypeptide binding]; other site 885275009845 putative PBP binding regions; other site 885275009846 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 885275009847 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 885275009848 dimer interface [polypeptide binding]; other site 885275009849 putative PBP binding regions; other site 885275009850 ABC-ATPase subunit interface; other site 885275009851 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 885275009852 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 885275009853 Walker A/P-loop; other site 885275009854 ATP binding site [chemical binding]; other site 885275009855 Q-loop/lid; other site 885275009856 ABC transporter signature motif; other site 885275009857 Walker B; other site 885275009858 D-loop; other site 885275009859 H-loop/switch region; other site 885275009860 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 885275009861 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885275009862 N-terminal plug; other site 885275009863 ligand-binding site [chemical binding]; other site 885275009864 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 885275009865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275009866 ATP binding site [chemical binding]; other site 885275009867 Mg2+ binding site [ion binding]; other site 885275009868 G-X-G motif; other site 885275009869 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 885275009870 anchoring element; other site 885275009871 dimer interface [polypeptide binding]; other site 885275009872 ATP binding site [chemical binding]; other site 885275009873 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 885275009874 active site 885275009875 metal binding site [ion binding]; metal-binding site 885275009876 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 885275009877 esterase YqiA; Provisional; Region: PRK11071 885275009878 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 885275009879 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 885275009880 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 885275009881 active site 885275009882 metal binding site [ion binding]; metal-binding site 885275009883 hexamer interface [polypeptide binding]; other site 885275009884 putative dehydrogenase; Provisional; Region: PRK11039 885275009885 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 885275009886 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 885275009887 dimer interface [polypeptide binding]; other site 885275009888 ADP-ribose binding site [chemical binding]; other site 885275009889 active site 885275009890 nudix motif; other site 885275009891 metal binding site [ion binding]; metal-binding site 885275009892 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 885275009893 hypothetical protein; Provisional; Region: PRK11653 885275009894 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 885275009895 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 885275009896 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 885275009897 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 885275009898 catalytic residues [active] 885275009899 hinge region; other site 885275009900 alpha helical domain; other site 885275009901 putative disulfide oxidoreductase; Provisional; Region: PRK04307 885275009902 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 885275009903 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 885275009904 putative active site [active] 885275009905 metal binding site [ion binding]; metal-binding site 885275009906 zinc transporter ZupT; Provisional; Region: PRK04201 885275009907 ZIP Zinc transporter; Region: Zip; pfam02535 885275009908 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 885275009909 putative fimbrial protein; Provisional; Region: PRK09733 885275009910 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 885275009911 PapC N-terminal domain; Region: PapC_N; pfam13954 885275009912 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 885275009913 PapC C-terminal domain; Region: PapC_C; pfam13953 885275009914 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 885275009915 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 885275009916 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 885275009917 Fimbrial protein; Region: Fimbrial; pfam00419 885275009918 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 885275009919 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 885275009920 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 885275009921 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 885275009922 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 885275009923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 885275009924 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 885275009925 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 885275009926 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 885275009927 putative ribose interaction site [chemical binding]; other site 885275009928 putative ADP binding site [chemical binding]; other site 885275009929 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 885275009930 active site 885275009931 nucleotide binding site [chemical binding]; other site 885275009932 HIGH motif; other site 885275009933 KMSKS motif; other site 885275009934 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 885275009935 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 885275009936 metal binding triad; other site 885275009937 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 885275009938 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 885275009939 metal binding triad; other site 885275009940 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 885275009941 Uncharacterized conserved protein [Function unknown]; Region: COG3025 885275009942 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 885275009943 putative active site [active] 885275009944 putative metal binding residues [ion binding]; other site 885275009945 signature motif; other site 885275009946 putative triphosphate binding site [ion binding]; other site 885275009947 CHAD domain; Region: CHAD; pfam05235 885275009948 Transposase IS200 like; Region: Y1_Tnp; pfam01797 885275009949 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 885275009950 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 885275009951 Probable transposase; Region: OrfB_IS605; pfam01385 885275009952 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 885275009953 SH3 domain-containing protein; Provisional; Region: PRK10884 885275009954 Bacterial SH3 domain homologues; Region: SH3b; smart00287 885275009955 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 885275009956 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 885275009957 active site 885275009958 NTP binding site [chemical binding]; other site 885275009959 metal binding triad [ion binding]; metal-binding site 885275009960 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 885275009961 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 885275009962 Zn2+ binding site [ion binding]; other site 885275009963 Mg2+ binding site [ion binding]; other site 885275009964 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 885275009965 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 885275009966 homooctamer interface [polypeptide binding]; other site 885275009967 active site 885275009968 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 885275009969 transcriptional activator TtdR; Provisional; Region: PRK09801 885275009970 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275009971 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 885275009972 putative effector binding pocket; other site 885275009973 putative dimerization interface [polypeptide binding]; other site 885275009974 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 885275009975 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 885275009976 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 885275009977 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 885275009978 transmembrane helices; other site 885275009979 UGMP family protein; Validated; Region: PRK09604 885275009980 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 885275009981 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 885275009982 DNA primase; Validated; Region: dnaG; PRK05667 885275009983 CHC2 zinc finger; Region: zf-CHC2; pfam01807 885275009984 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 885275009985 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 885275009986 active site 885275009987 metal binding site [ion binding]; metal-binding site 885275009988 interdomain interaction site; other site 885275009989 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 885275009990 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 885275009991 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 885275009992 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 885275009993 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 885275009994 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 885275009995 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 885275009996 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 885275009997 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 885275009998 DNA binding residues [nucleotide binding] 885275009999 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 885275010000 active site 885275010001 SUMO-1 interface [polypeptide binding]; other site 885275010002 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 885275010003 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 885275010004 FAD binding pocket [chemical binding]; other site 885275010005 FAD binding motif [chemical binding]; other site 885275010006 phosphate binding motif [ion binding]; other site 885275010007 NAD binding pocket [chemical binding]; other site 885275010008 Predicted transcriptional regulators [Transcription]; Region: COG1695 885275010009 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 885275010010 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 885275010011 PAS fold; Region: PAS_3; pfam08447 885275010012 putative active site [active] 885275010013 heme pocket [chemical binding]; other site 885275010014 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 885275010015 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 885275010016 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 885275010017 dimer interface [polypeptide binding]; other site 885275010018 putative CheW interface [polypeptide binding]; other site 885275010019 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 885275010020 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 885275010021 inhibitor-cofactor binding pocket; inhibition site 885275010022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275010023 catalytic residue [active] 885275010024 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 885275010025 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 885275010026 DNA binding site [nucleotide binding] 885275010027 domain linker motif; other site 885275010028 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 885275010029 putative dimerization interface [polypeptide binding]; other site 885275010030 putative ligand binding site [chemical binding]; other site 885275010031 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 885275010032 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 885275010033 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 885275010034 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 885275010035 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 885275010036 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 885275010037 inner membrane transporter YjeM; Provisional; Region: PRK15238 885275010038 alpha-glucosidase; Provisional; Region: PRK10137 885275010039 Protein of unknown function, DUF608; Region: DUF608; pfam04685 885275010040 Trehalase; Region: Trehalase; cl17346 885275010041 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 885275010042 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 885275010043 active site 885275010044 FMN binding site [chemical binding]; other site 885275010045 2,4-decadienoyl-CoA binding site; other site 885275010046 catalytic residue [active] 885275010047 4Fe-4S cluster binding site [ion binding]; other site 885275010048 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 885275010049 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 885275010050 non-specific DNA binding site [nucleotide binding]; other site 885275010051 salt bridge; other site 885275010052 sequence-specific DNA binding site [nucleotide binding]; other site 885275010053 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 885275010054 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 885275010055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275010056 S-adenosylmethionine binding site [chemical binding]; other site 885275010057 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 885275010058 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 885275010059 putative active site [active] 885275010060 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 885275010061 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 885275010062 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 885275010063 serine/threonine transporter SstT; Provisional; Region: PRK13628 885275010064 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 885275010065 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 885275010066 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 885275010067 galactarate dehydratase; Region: galactar-dH20; TIGR03248 885275010068 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 885275010069 Glucuronate isomerase; Region: UxaC; pfam02614 885275010070 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 885275010071 D-galactonate transporter; Region: 2A0114; TIGR00893 885275010072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275010073 putative substrate translocation pore; other site 885275010074 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 885275010075 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885275010076 DNA-binding site [nucleotide binding]; DNA binding site 885275010077 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 885275010078 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 885275010079 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 885275010080 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 885275010081 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 885275010082 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 885275010083 Predicted membrane protein [Function unknown]; Region: COG5393 885275010084 YqjK-like protein; Region: YqjK; pfam13997 885275010085 Predicted membrane protein [Function unknown]; Region: COG2259 885275010086 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 885275010087 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 885275010088 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 885275010089 putative dimer interface [polypeptide binding]; other site 885275010090 N-terminal domain interface [polypeptide binding]; other site 885275010091 putative substrate binding pocket (H-site) [chemical binding]; other site 885275010092 Predicted membrane protein [Function unknown]; Region: COG3152 885275010093 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275010094 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 885275010095 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 885275010096 dimerization interface [polypeptide binding]; other site 885275010097 Pirin-related protein [General function prediction only]; Region: COG1741 885275010098 Pirin; Region: Pirin; pfam02678 885275010099 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 885275010100 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 885275010101 serine transporter; Region: stp; TIGR00814 885275010102 L-serine dehydratase TdcG; Provisional; Region: PRK15040 885275010103 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 885275010104 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 885275010105 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 885275010106 homotrimer interaction site [polypeptide binding]; other site 885275010107 putative active site [active] 885275010108 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 885275010109 Pyruvate formate lyase 1; Region: PFL1; cd01678 885275010110 coenzyme A binding site [chemical binding]; other site 885275010111 active site 885275010112 catalytic residues [active] 885275010113 glycine loop; other site 885275010114 propionate/acetate kinase; Provisional; Region: PRK12379 885275010115 Acetokinase family; Region: Acetate_kinase; cl17229 885275010116 threonine/serine transporter TdcC; Provisional; Region: PRK13629 885275010117 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 885275010118 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 885275010119 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 885275010120 tetramer interface [polypeptide binding]; other site 885275010121 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275010122 catalytic residue [active] 885275010123 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 885275010124 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275010125 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 885275010126 putative substrate binding pocket [chemical binding]; other site 885275010127 putative dimerization interface [polypeptide binding]; other site 885275010128 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 885275010129 glycerate kinase I; Provisional; Region: PRK10342 885275010130 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 885275010131 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 885275010132 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 885275010133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275010134 D-galactonate transporter; Region: 2A0114; TIGR00893 885275010135 putative substrate translocation pore; other site 885275010136 galactarate dehydratase; Region: galactar-dH20; TIGR03248 885275010137 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 885275010138 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 885275010139 putative regulator PrlF; Provisional; Region: PRK09974 885275010140 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 885275010141 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 885275010142 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 885275010143 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 885275010144 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 885275010145 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 885275010146 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 885275010147 active site 885275010148 phosphorylation site [posttranslational modification] 885275010149 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 885275010150 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 885275010151 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 885275010152 active pocket/dimerization site; other site 885275010153 active site 885275010154 phosphorylation site [posttranslational modification] 885275010155 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 885275010156 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 885275010157 active site 885275010158 dimer interface [polypeptide binding]; other site 885275010159 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 885275010160 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 885275010161 dimer interface [polypeptide binding]; other site 885275010162 active site 885275010163 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 885275010164 putative active site [active] 885275010165 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453 885275010166 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 885275010167 active site 885275010168 intersubunit interface [polypeptide binding]; other site 885275010169 zinc binding site [ion binding]; other site 885275010170 Na+ binding site [ion binding]; other site 885275010171 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 885275010172 active site 885275010173 phosphorylation site [posttranslational modification] 885275010174 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 885275010175 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 885275010176 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 885275010177 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 885275010178 active site 885275010179 trimer interface [polypeptide binding]; other site 885275010180 allosteric site; other site 885275010181 active site lid [active] 885275010182 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 885275010183 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 885275010184 putative SAM binding site [chemical binding]; other site 885275010185 putative homodimer interface [polypeptide binding]; other site 885275010186 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 885275010187 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 885275010188 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 885275010189 putative ligand binding site [chemical binding]; other site 885275010190 TIGR00252 family protein; Region: TIGR00252 885275010191 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 885275010192 dimer interface [polypeptide binding]; other site 885275010193 active site 885275010194 outer membrane lipoprotein; Provisional; Region: PRK11023 885275010195 BON domain; Region: BON; pfam04972 885275010196 BON domain; Region: BON; pfam04972 885275010197 Predicted permease; Region: DUF318; pfam03773 885275010198 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 885275010199 NADH(P)-binding; Region: NAD_binding_10; pfam13460 885275010200 NAD binding site [chemical binding]; other site 885275010201 active site 885275010202 hypothetical protein; Provisional; Region: PRK03467 885275010203 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 885275010204 GIY-YIG motif/motif A; other site 885275010205 putative active site [active] 885275010206 putative metal binding site [ion binding]; other site 885275010207 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 885275010208 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 885275010209 Coenzyme A binding pocket [chemical binding]; other site 885275010210 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 885275010211 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 885275010212 Peptidase family U32; Region: Peptidase_U32; pfam01136 885275010213 putative protease; Provisional; Region: PRK15447 885275010214 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 885275010215 hypothetical protein; Provisional; Region: PRK10508 885275010216 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 885275010217 tryptophan permease; Provisional; Region: PRK10483 885275010218 aromatic amino acid transport protein; Region: araaP; TIGR00837 885275010219 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 885275010220 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 885275010221 ATP binding site [chemical binding]; other site 885275010222 Mg++ binding site [ion binding]; other site 885275010223 motif III; other site 885275010224 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 885275010225 nucleotide binding region [chemical binding]; other site 885275010226 ATP-binding site [chemical binding]; other site 885275010227 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 885275010228 putative RNA binding site [nucleotide binding]; other site 885275010229 lipoprotein NlpI; Provisional; Region: PRK11189 885275010230 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 885275010231 binding surface 885275010232 TPR motif; other site 885275010233 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 885275010234 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 885275010235 RNase E interface [polypeptide binding]; other site 885275010236 trimer interface [polypeptide binding]; other site 885275010237 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 885275010238 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 885275010239 RNase E interface [polypeptide binding]; other site 885275010240 trimer interface [polypeptide binding]; other site 885275010241 active site 885275010242 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 885275010243 putative nucleic acid binding region [nucleotide binding]; other site 885275010244 G-X-X-G motif; other site 885275010245 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 885275010246 RNA binding site [nucleotide binding]; other site 885275010247 domain interface; other site 885275010248 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 885275010249 16S/18S rRNA binding site [nucleotide binding]; other site 885275010250 S13e-L30e interaction site [polypeptide binding]; other site 885275010251 25S rRNA binding site [nucleotide binding]; other site 885275010252 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 885275010253 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 885275010254 RNA binding site [nucleotide binding]; other site 885275010255 active site 885275010256 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 885275010257 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 885275010258 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 885275010259 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 885275010260 translation initiation factor IF-2; Region: IF-2; TIGR00487 885275010261 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 885275010262 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 885275010263 G1 box; other site 885275010264 putative GEF interaction site [polypeptide binding]; other site 885275010265 GTP/Mg2+ binding site [chemical binding]; other site 885275010266 Switch I region; other site 885275010267 G2 box; other site 885275010268 G3 box; other site 885275010269 Switch II region; other site 885275010270 G4 box; other site 885275010271 G5 box; other site 885275010272 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 885275010273 Translation-initiation factor 2; Region: IF-2; pfam11987 885275010274 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 885275010275 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 885275010276 NusA N-terminal domain; Region: NusA_N; pfam08529 885275010277 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 885275010278 RNA binding site [nucleotide binding]; other site 885275010279 homodimer interface [polypeptide binding]; other site 885275010280 NusA-like KH domain; Region: KH_5; pfam13184 885275010281 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 885275010282 G-X-X-G motif; other site 885275010283 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 885275010284 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 885275010285 ribosome maturation protein RimP; Reviewed; Region: PRK00092 885275010286 Sm and related proteins; Region: Sm_like; cl00259 885275010287 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 885275010288 putative oligomer interface [polypeptide binding]; other site 885275010289 putative RNA binding site [nucleotide binding]; other site 885275010290 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 885275010291 ANP binding site [chemical binding]; other site 885275010292 Substrate Binding Site II [chemical binding]; other site 885275010293 Substrate Binding Site I [chemical binding]; other site 885275010294 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 885275010295 Sulfatase; Region: Sulfatase; pfam00884 885275010296 Preprotein translocase SecG subunit; Region: SecG; pfam03840 885275010297 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 885275010298 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 885275010299 active site 885275010300 substrate binding site [chemical binding]; other site 885275010301 metal binding site [ion binding]; metal-binding site 885275010302 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 885275010303 dihydropteroate synthase; Region: DHPS; TIGR01496 885275010304 substrate binding pocket [chemical binding]; other site 885275010305 dimer interface [polypeptide binding]; other site 885275010306 inhibitor binding site; inhibition site 885275010307 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 885275010308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275010309 Walker A motif; other site 885275010310 ATP binding site [chemical binding]; other site 885275010311 Walker B motif; other site 885275010312 arginine finger; other site 885275010313 Peptidase family M41; Region: Peptidase_M41; pfam01434 885275010314 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 885275010315 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275010316 S-adenosylmethionine binding site [chemical binding]; other site 885275010317 RNA-binding protein YhbY; Provisional; Region: PRK10343 885275010318 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 885275010319 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 885275010320 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 885275010321 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 885275010322 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 885275010323 GTPase CgtA; Reviewed; Region: obgE; PRK12298 885275010324 GTP1/OBG; Region: GTP1_OBG; pfam01018 885275010325 Obg GTPase; Region: Obg; cd01898 885275010326 G1 box; other site 885275010327 GTP/Mg2+ binding site [chemical binding]; other site 885275010328 Switch I region; other site 885275010329 G2 box; other site 885275010330 G3 box; other site 885275010331 Switch II region; other site 885275010332 G4 box; other site 885275010333 G5 box; other site 885275010334 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 885275010335 EamA-like transporter family; Region: EamA; pfam00892 885275010336 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 885275010337 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 885275010338 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 885275010339 substrate binding pocket [chemical binding]; other site 885275010340 chain length determination region; other site 885275010341 substrate-Mg2+ binding site; other site 885275010342 catalytic residues [active] 885275010343 aspartate-rich region 1; other site 885275010344 active site lid residues [active] 885275010345 aspartate-rich region 2; other site 885275010346 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 885275010347 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 885275010348 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 885275010349 hinge; other site 885275010350 active site 885275010351 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 885275010352 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 885275010353 anti sigma factor interaction site; other site 885275010354 regulatory phosphorylation site [posttranslational modification]; other site 885275010355 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 885275010356 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 885275010357 mce related protein; Region: MCE; pfam02470 885275010358 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 885275010359 conserved hypothetical integral membrane protein; Region: TIGR00056 885275010360 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 885275010361 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 885275010362 Walker A/P-loop; other site 885275010363 ATP binding site [chemical binding]; other site 885275010364 Q-loop/lid; other site 885275010365 ABC transporter signature motif; other site 885275010366 Walker B; other site 885275010367 D-loop; other site 885275010368 H-loop/switch region; other site 885275010369 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 885275010370 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 885275010371 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 885275010372 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 885275010373 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 885275010374 putative active site [active] 885275010375 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 885275010376 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 885275010377 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 885275010378 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 885275010379 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 885275010380 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 885275010381 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 885275010382 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 885275010383 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 885275010384 Walker A/P-loop; other site 885275010385 ATP binding site [chemical binding]; other site 885275010386 Q-loop/lid; other site 885275010387 ABC transporter signature motif; other site 885275010388 Walker B; other site 885275010389 D-loop; other site 885275010390 H-loop/switch region; other site 885275010391 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 885275010392 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 885275010393 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 885275010394 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 885275010395 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 885275010396 30S subunit binding site; other site 885275010397 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 885275010398 active site 885275010399 phosphorylation site [posttranslational modification] 885275010400 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 885275010401 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 885275010402 dimerization domain swap beta strand [polypeptide binding]; other site 885275010403 regulatory protein interface [polypeptide binding]; other site 885275010404 active site 885275010405 regulatory phosphorylation site [posttranslational modification]; other site 885275010406 hypothetical protein; Provisional; Region: PRK10345 885275010407 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 885275010408 Transglycosylase; Region: Transgly; cl17702 885275010409 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 885275010410 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 885275010411 conserved cys residue [active] 885275010412 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 885275010413 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 885275010414 putative active site [active] 885275010415 heme pocket [chemical binding]; other site 885275010416 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885275010417 dimer interface [polypeptide binding]; other site 885275010418 phosphorylation site [posttranslational modification] 885275010419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275010420 ATP binding site [chemical binding]; other site 885275010421 Mg2+ binding site [ion binding]; other site 885275010422 G-X-G motif; other site 885275010423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275010424 active site 885275010425 phosphorylation site [posttranslational modification] 885275010426 intermolecular recognition site; other site 885275010427 dimerization interface [polypeptide binding]; other site 885275010428 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 885275010429 putative binding surface; other site 885275010430 active site 885275010431 radical SAM protein, TIGR01212 family; Region: TIGR01212 885275010432 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885275010433 FeS/SAM binding site; other site 885275010434 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 885275010435 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 885275010436 active site 885275010437 dimer interface [polypeptide binding]; other site 885275010438 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 885275010439 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 885275010440 active site 885275010441 FMN binding site [chemical binding]; other site 885275010442 substrate binding site [chemical binding]; other site 885275010443 3Fe-4S cluster binding site [ion binding]; other site 885275010444 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 885275010445 domain interface; other site 885275010446 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 885275010447 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 885275010448 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 885275010449 Domain of unknown function (DUF386); Region: DUF386; cl01047 885275010450 N-acetylmannosamine kinase; Provisional; Region: PRK05082 885275010451 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 885275010452 nucleotide binding site [chemical binding]; other site 885275010453 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 885275010454 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 885275010455 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 885275010456 putative active site cavity [active] 885275010457 putative sialic acid transporter; Provisional; Region: PRK03893 885275010458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275010459 putative substrate translocation pore; other site 885275010460 N-acetylneuraminate lyase; Region: nanA; TIGR00683 885275010461 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 885275010462 inhibitor site; inhibition site 885275010463 active site 885275010464 dimer interface [polypeptide binding]; other site 885275010465 catalytic residue [active] 885275010466 transcriptional regulator NanR; Provisional; Region: PRK03837 885275010467 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885275010468 DNA-binding site [nucleotide binding]; DNA binding site 885275010469 FCD domain; Region: FCD; pfam07729 885275010470 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 885275010471 stringent starvation protein A; Provisional; Region: sspA; PRK09481 885275010472 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 885275010473 C-terminal domain interface [polypeptide binding]; other site 885275010474 putative GSH binding site (G-site) [chemical binding]; other site 885275010475 dimer interface [polypeptide binding]; other site 885275010476 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 885275010477 dimer interface [polypeptide binding]; other site 885275010478 N-terminal domain interface [polypeptide binding]; other site 885275010479 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 885275010480 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 885275010481 23S rRNA interface [nucleotide binding]; other site 885275010482 L3 interface [polypeptide binding]; other site 885275010483 Predicted ATPase [General function prediction only]; Region: COG1485 885275010484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 885275010485 hypothetical protein; Provisional; Region: PRK11677 885275010486 serine endoprotease; Provisional; Region: PRK10139 885275010487 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 885275010488 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 885275010489 protein binding site [polypeptide binding]; other site 885275010490 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 885275010491 serine endoprotease; Provisional; Region: PRK10898 885275010492 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 885275010493 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 885275010494 malate dehydrogenase; Provisional; Region: PRK05086 885275010495 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 885275010496 NAD binding site [chemical binding]; other site 885275010497 dimerization interface [polypeptide binding]; other site 885275010498 Substrate binding site [chemical binding]; other site 885275010499 arginine repressor; Provisional; Region: PRK05066 885275010500 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 885275010501 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 885275010502 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 885275010503 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 885275010504 RNAase interaction site [polypeptide binding]; other site 885275010505 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 885275010506 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 885275010507 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 885275010508 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885275010509 HlyD family secretion protein; Region: HlyD_3; pfam13437 885275010510 efflux system membrane protein; Provisional; Region: PRK11594 885275010511 transcriptional regulator; Provisional; Region: PRK10632 885275010512 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275010513 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 885275010514 putative effector binding pocket; other site 885275010515 dimerization interface [polypeptide binding]; other site 885275010516 protease TldD; Provisional; Region: tldD; PRK10735 885275010517 hypothetical protein; Provisional; Region: PRK10899 885275010518 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 885275010519 ribonuclease G; Provisional; Region: PRK11712 885275010520 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 885275010521 homodimer interface [polypeptide binding]; other site 885275010522 oligonucleotide binding site [chemical binding]; other site 885275010523 Maf-like protein; Region: Maf; pfam02545 885275010524 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 885275010525 active site 885275010526 dimer interface [polypeptide binding]; other site 885275010527 rod shape-determining protein MreD; Provisional; Region: PRK11060 885275010528 rod shape-determining protein MreC; Region: mreC; TIGR00219 885275010529 rod shape-determining protein MreC; Region: MreC; pfam04085 885275010530 rod shape-determining protein MreB; Provisional; Region: PRK13927 885275010531 MreB and similar proteins; Region: MreB_like; cd10225 885275010532 nucleotide binding site [chemical binding]; other site 885275010533 Mg binding site [ion binding]; other site 885275010534 putative protofilament interaction site [polypeptide binding]; other site 885275010535 RodZ interaction site [polypeptide binding]; other site 885275010536 regulatory protein CsrD; Provisional; Region: PRK11059 885275010537 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885275010538 metal binding site [ion binding]; metal-binding site 885275010539 active site 885275010540 I-site; other site 885275010541 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885275010542 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 885275010543 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 885275010544 NADP binding site [chemical binding]; other site 885275010545 dimer interface [polypeptide binding]; other site 885275010546 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 885275010547 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 885275010548 carboxyltransferase (CT) interaction site; other site 885275010549 biotinylation site [posttranslational modification]; other site 885275010550 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 885275010551 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 885275010552 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 885275010553 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 885275010554 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 885275010555 active site 885275010556 catalytic residues [active] 885275010557 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 885275010558 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 885275010559 substrate binding site [chemical binding]; other site 885275010560 ATP binding site [chemical binding]; other site 885275010561 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 885275010562 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 885275010563 TM-ABC transporter signature motif; other site 885275010564 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 885275010565 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 885275010566 Walker A/P-loop; other site 885275010567 ATP binding site [chemical binding]; other site 885275010568 Q-loop/lid; other site 885275010569 ABC transporter signature motif; other site 885275010570 Walker B; other site 885275010571 D-loop; other site 885275010572 H-loop/switch region; other site 885275010573 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 885275010574 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 885275010575 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_12; cd06322 885275010576 putative ligand binding site [chemical binding]; other site 885275010577 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 885275010578 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 885275010579 intersubunit interface [polypeptide binding]; other site 885275010580 active site 885275010581 zinc binding site [ion binding]; other site 885275010582 Na+ binding site [ion binding]; other site 885275010583 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 885275010584 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 885275010585 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 885275010586 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 885275010587 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 885275010588 substrate binding site [chemical binding]; other site 885275010589 ATP binding site [chemical binding]; other site 885275010590 hypothetical protein; Provisional; Region: PRK10633 885275010591 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 885275010592 Na binding site [ion binding]; other site 885275010593 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 885275010594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 885275010595 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 885275010596 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 885275010597 FMN binding site [chemical binding]; other site 885275010598 active site 885275010599 catalytic residues [active] 885275010600 substrate binding site [chemical binding]; other site 885275010601 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 885275010602 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 885275010603 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 885275010604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275010605 DNA methylase; Region: N6_N4_Mtase; pfam01555 885275010606 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 885275010607 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 885275010608 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 885275010609 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 885275010610 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 885275010611 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885275010612 HlyD family secretion protein; Region: HlyD_3; pfam13437 885275010613 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 885275010614 Protein export membrane protein; Region: SecD_SecF; cl14618 885275010615 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 885275010616 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 885275010617 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 885275010618 substrate binding pocket [chemical binding]; other site 885275010619 membrane-bound complex binding site; other site 885275010620 hinge residues; other site 885275010621 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 885275010622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275010623 conserved gate region; other site 885275010624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275010625 dimer interface [polypeptide binding]; other site 885275010626 conserved gate region; other site 885275010627 putative PBP binding loops; other site 885275010628 ABC-ATPase subunit interface; other site 885275010629 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 885275010630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275010631 dimer interface [polypeptide binding]; other site 885275010632 conserved gate region; other site 885275010633 putative PBP binding loops; other site 885275010634 ABC-ATPase subunit interface; other site 885275010635 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 885275010636 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 885275010637 Walker A/P-loop; other site 885275010638 ATP binding site [chemical binding]; other site 885275010639 Q-loop/lid; other site 885275010640 ABC transporter signature motif; other site 885275010641 Walker B; other site 885275010642 D-loop; other site 885275010643 H-loop/switch region; other site 885275010644 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 885275010645 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 885275010646 trimer interface [polypeptide binding]; other site 885275010647 putative metal binding site [ion binding]; other site 885275010648 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 885275010649 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 885275010650 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 885275010651 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 885275010652 shikimate binding site; other site 885275010653 NAD(P) binding site [chemical binding]; other site 885275010654 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 885275010655 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 885275010656 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 885275010657 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 885275010658 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 885275010659 hypothetical protein; Validated; Region: PRK03430 885275010660 hypothetical protein; Provisional; Region: PRK10736 885275010661 DNA protecting protein DprA; Region: dprA; TIGR00732 885275010662 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 885275010663 active site 885275010664 catalytic residues [active] 885275010665 metal binding site [ion binding]; metal-binding site 885275010666 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 885275010667 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 885275010668 putative active site [active] 885275010669 substrate binding site [chemical binding]; other site 885275010670 putative cosubstrate binding site; other site 885275010671 catalytic site [active] 885275010672 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 885275010673 substrate binding site [chemical binding]; other site 885275010674 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 885275010675 putative RNA binding site [nucleotide binding]; other site 885275010676 16S rRNA methyltransferase B; Provisional; Region: PRK10901 885275010677 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275010678 S-adenosylmethionine binding site [chemical binding]; other site 885275010679 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 885275010680 TrkA-N domain; Region: TrkA_N; pfam02254 885275010681 TrkA-C domain; Region: TrkA_C; pfam02080 885275010682 TrkA-N domain; Region: TrkA_N; pfam02254 885275010683 TrkA-C domain; Region: TrkA_C; pfam02080 885275010684 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 885275010685 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 885275010686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 885275010687 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 885275010688 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 885275010689 DNA binding residues [nucleotide binding] 885275010690 dimer interface [polypeptide binding]; other site 885275010691 metal binding site [ion binding]; metal-binding site 885275010692 hypothetical protein; Provisional; Region: PRK10203 885275010693 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 885275010694 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 885275010695 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 885275010696 alphaNTD homodimer interface [polypeptide binding]; other site 885275010697 alphaNTD - beta interaction site [polypeptide binding]; other site 885275010698 alphaNTD - beta' interaction site [polypeptide binding]; other site 885275010699 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 885275010700 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 885275010701 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 885275010702 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 885275010703 RNA binding surface [nucleotide binding]; other site 885275010704 30S ribosomal protein S11; Validated; Region: PRK05309 885275010705 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 885275010706 30S ribosomal protein S13; Region: bact_S13; TIGR03631 885275010707 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 885275010708 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 885275010709 SecY translocase; Region: SecY; pfam00344 885275010710 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 885275010711 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 885275010712 23S rRNA binding site [nucleotide binding]; other site 885275010713 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 885275010714 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 885275010715 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 885275010716 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 885275010717 23S rRNA interface [nucleotide binding]; other site 885275010718 5S rRNA interface [nucleotide binding]; other site 885275010719 L27 interface [polypeptide binding]; other site 885275010720 L5 interface [polypeptide binding]; other site 885275010721 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 885275010722 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 885275010723 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 885275010724 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 885275010725 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 885275010726 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 885275010727 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 885275010728 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 885275010729 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 885275010730 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 885275010731 RNA binding site [nucleotide binding]; other site 885275010732 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 885275010733 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 885275010734 23S rRNA interface [nucleotide binding]; other site 885275010735 putative translocon interaction site; other site 885275010736 signal recognition particle (SRP54) interaction site; other site 885275010737 L23 interface [polypeptide binding]; other site 885275010738 trigger factor interaction site; other site 885275010739 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 885275010740 23S rRNA interface [nucleotide binding]; other site 885275010741 5S rRNA interface [nucleotide binding]; other site 885275010742 putative antibiotic binding site [chemical binding]; other site 885275010743 L25 interface [polypeptide binding]; other site 885275010744 L27 interface [polypeptide binding]; other site 885275010745 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 885275010746 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 885275010747 G-X-X-G motif; other site 885275010748 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 885275010749 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 885275010750 protein-rRNA interface [nucleotide binding]; other site 885275010751 putative translocon binding site; other site 885275010752 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 885275010753 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 885275010754 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 885275010755 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 885275010756 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 885275010757 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 885275010758 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 885275010759 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 885275010760 protein secretion protein GspB; Provisional; Region: PRK09697 885275010761 AAA domain; Region: AAA_22; pfam13401 885275010762 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 885275010763 Type II secretory pathway, component PulC [Intracellular trafficking and secretion]; Region: PulC; COG3031 885275010764 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 885275010765 type II secretion system protein D; Region: type_II_gspD; TIGR02517 885275010766 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 885275010767 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 885275010768 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 885275010769 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 885275010770 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 885275010771 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 885275010772 Walker A motif; other site 885275010773 ATP binding site [chemical binding]; other site 885275010774 Walker B motif; other site 885275010775 type II secretion system protein F; Region: GspF; TIGR02120 885275010776 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 885275010777 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 885275010778 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 885275010779 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 885275010780 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 885275010781 Type II transport protein GspH; Region: GspH; pfam12019 885275010782 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 885275010783 type II secretion system protein I; Region: gspI; TIGR01707 885275010784 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 885275010785 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 885275010786 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 885275010787 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 885275010788 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 885275010789 Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297 885275010790 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 885275010791 GspL periplasmic domain; Region: GspL_C; pfam12693 885275010792 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 885275010793 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 885275010794 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 885275010795 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 885275010796 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 885275010797 heme binding site [chemical binding]; other site 885275010798 ferroxidase pore; other site 885275010799 ferroxidase diiron center [ion binding]; other site 885275010800 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 885275010801 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 885275010802 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 885275010803 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 885275010804 aromatic chitin/cellulose binding site residues [chemical binding]; other site 885275010805 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 885275010806 active site 885275010807 elongation factor Tu; Reviewed; Region: PRK00049 885275010808 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 885275010809 G1 box; other site 885275010810 GEF interaction site [polypeptide binding]; other site 885275010811 GTP/Mg2+ binding site [chemical binding]; other site 885275010812 Switch I region; other site 885275010813 G2 box; other site 885275010814 G3 box; other site 885275010815 Switch II region; other site 885275010816 G4 box; other site 885275010817 G5 box; other site 885275010818 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 885275010819 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 885275010820 Antibiotic Binding Site [chemical binding]; other site 885275010821 elongation factor G; Reviewed; Region: PRK00007 885275010822 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 885275010823 G1 box; other site 885275010824 putative GEF interaction site [polypeptide binding]; other site 885275010825 GTP/Mg2+ binding site [chemical binding]; other site 885275010826 Switch I region; other site 885275010827 G2 box; other site 885275010828 G3 box; other site 885275010829 Switch II region; other site 885275010830 G4 box; other site 885275010831 G5 box; other site 885275010832 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 885275010833 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 885275010834 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 885275010835 30S ribosomal protein S7; Validated; Region: PRK05302 885275010836 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 885275010837 S17 interaction site [polypeptide binding]; other site 885275010838 S8 interaction site; other site 885275010839 16S rRNA interaction site [nucleotide binding]; other site 885275010840 streptomycin interaction site [chemical binding]; other site 885275010841 23S rRNA interaction site [nucleotide binding]; other site 885275010842 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 885275010843 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 885275010844 sulfur relay protein TusC; Validated; Region: PRK00211 885275010845 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 885275010846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 885275010847 YheO-like PAS domain; Region: PAS_6; pfam08348 885275010848 HTH domain; Region: HTH_22; pfam13309 885275010849 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 885275010850 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 885275010851 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 885275010852 phi X174 lysis protein; Provisional; Region: PRK02793 885275010853 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 885275010854 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 885275010855 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 885275010856 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 885275010857 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 885275010858 TrkA-N domain; Region: TrkA_N; pfam02254 885275010859 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 885275010860 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 885275010861 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885275010862 Walker A/P-loop; other site 885275010863 ATP binding site [chemical binding]; other site 885275010864 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 885275010865 ABC transporter signature motif; other site 885275010866 Walker B; other site 885275010867 D-loop; other site 885275010868 ABC transporter; Region: ABC_tran_2; pfam12848 885275010869 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 885275010870 putative hydrolase; Provisional; Region: PRK10985 885275010871 hypothetical protein; Provisional; Region: PRK04966 885275010872 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 885275010873 active site 885275010874 hypothetical protein; Provisional; Region: PRK10738 885275010875 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 885275010876 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 885275010877 ligand binding site [chemical binding]; other site 885275010878 flexible hinge region; other site 885275010879 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 885275010880 putative switch regulator; other site 885275010881 non-specific DNA interactions [nucleotide binding]; other site 885275010882 DNA binding site [nucleotide binding] 885275010883 sequence specific DNA binding site [nucleotide binding]; other site 885275010884 putative cAMP binding site [chemical binding]; other site 885275010885 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 885275010886 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 885275010887 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 885275010888 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 885275010889 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 885275010890 inhibitor-cofactor binding pocket; inhibition site 885275010891 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275010892 catalytic residue [active] 885275010893 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 885275010894 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 885275010895 glutamine binding [chemical binding]; other site 885275010896 catalytic triad [active] 885275010897 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 885275010898 cell filamentation protein Fic; Provisional; Region: PRK10347 885275010899 hypothetical protein; Provisional; Region: PRK10204 885275010900 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 885275010901 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 885275010902 substrate binding site [chemical binding]; other site 885275010903 putative transporter; Provisional; Region: PRK03699 885275010904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275010905 putative substrate translocation pore; other site 885275010906 nitrite reductase subunit NirD; Provisional; Region: PRK14989 885275010907 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 885275010908 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 885275010909 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 885275010910 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 885275010911 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 885275010912 nitrite transporter NirC; Provisional; Region: PRK11562 885275010913 siroheme synthase; Provisional; Region: cysG; PRK10637 885275010914 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 885275010915 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 885275010916 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 885275010917 active site 885275010918 SAM binding site [chemical binding]; other site 885275010919 homodimer interface [polypeptide binding]; other site 885275010920 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 885275010921 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 885275010922 Protein of unknown function; Region: YhfT; pfam10797 885275010923 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 885275010924 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 885275010925 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 885275010926 active site 885275010927 substrate binding pocket [chemical binding]; other site 885275010928 homodimer interaction site [polypeptide binding]; other site 885275010929 putative mutase; Provisional; Region: PRK12383 885275010930 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015 885275010931 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 885275010932 dimer interface [polypeptide binding]; other site 885275010933 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 885275010934 active site 885275010935 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 885275010936 substrate binding site [chemical binding]; other site 885275010937 catalytic residue [active] 885275010938 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 885275010939 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 885275010940 active site 885275010941 HIGH motif; other site 885275010942 dimer interface [polypeptide binding]; other site 885275010943 KMSKS motif; other site 885275010944 phosphoglycolate phosphatase; Provisional; Region: PRK13222 885275010945 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885275010946 motif II; other site 885275010947 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 885275010948 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 885275010949 substrate binding site [chemical binding]; other site 885275010950 hexamer interface [polypeptide binding]; other site 885275010951 metal binding site [ion binding]; metal-binding site 885275010952 DNA adenine methylase; Provisional; Region: PRK10904 885275010953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 885275010954 cell division protein DamX; Validated; Region: PRK10905 885275010955 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 885275010956 active site 885275010957 dimer interface [polypeptide binding]; other site 885275010958 metal binding site [ion binding]; metal-binding site 885275010959 shikimate kinase; Reviewed; Region: aroK; PRK00131 885275010960 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 885275010961 ADP binding site [chemical binding]; other site 885275010962 magnesium binding site [ion binding]; other site 885275010963 putative shikimate binding site; other site 885275010964 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 885275010965 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 885275010966 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 885275010967 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 885275010968 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 885275010969 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 885275010970 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 885275010971 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 885275010972 Transglycosylase; Region: Transgly; pfam00912 885275010973 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 885275010974 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 885275010975 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 885275010976 ADP-ribose binding site [chemical binding]; other site 885275010977 dimer interface [polypeptide binding]; other site 885275010978 active site 885275010979 nudix motif; other site 885275010980 metal binding site [ion binding]; metal-binding site 885275010981 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 885275010982 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 885275010983 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885275010984 motif II; other site 885275010985 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 885275010986 RNA binding surface [nucleotide binding]; other site 885275010987 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 885275010988 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 885275010989 dimerization interface [polypeptide binding]; other site 885275010990 domain crossover interface; other site 885275010991 redox-dependent activation switch; other site 885275010992 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 885275010993 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 885275010994 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 885275010995 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 885275010996 active site 885275010997 substrate-binding site [chemical binding]; other site 885275010998 metal-binding site [ion binding] 885275010999 ATP binding site [chemical binding]; other site 885275011000 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 885275011001 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 885275011002 non-specific DNA binding site [nucleotide binding]; other site 885275011003 salt bridge; other site 885275011004 sequence-specific DNA binding site [nucleotide binding]; other site 885275011005 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 885275011006 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 885275011007 dimerization interface [polypeptide binding]; other site 885275011008 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885275011009 dimer interface [polypeptide binding]; other site 885275011010 phosphorylation site [posttranslational modification] 885275011011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275011012 ATP binding site [chemical binding]; other site 885275011013 G-X-G motif; other site 885275011014 osmolarity response regulator; Provisional; Region: ompR; PRK09468 885275011015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275011016 active site 885275011017 phosphorylation site [posttranslational modification] 885275011018 intermolecular recognition site; other site 885275011019 dimerization interface [polypeptide binding]; other site 885275011020 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 885275011021 DNA binding site [nucleotide binding] 885275011022 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 885275011023 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 885275011024 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 885275011025 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 885275011026 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 885275011027 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 885275011028 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 885275011029 RNA binding site [nucleotide binding]; other site 885275011030 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 885275011031 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 885275011032 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 885275011033 G1 box; other site 885275011034 GTP/Mg2+ binding site [chemical binding]; other site 885275011035 Switch I region; other site 885275011036 G2 box; other site 885275011037 G3 box; other site 885275011038 Switch II region; other site 885275011039 G4 box; other site 885275011040 G5 box; other site 885275011041 Nucleoside recognition; Region: Gate; pfam07670 885275011042 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 885275011043 Nucleoside recognition; Region: Gate; pfam07670 885275011044 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 885275011045 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 885275011046 carboxylesterase BioH; Provisional; Region: PRK10349 885275011047 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 885275011048 DNA utilization protein GntX; Provisional; Region: PRK11595 885275011049 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 885275011050 active site 885275011051 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 885275011052 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 885275011053 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 885275011054 high-affinity gluconate transporter; Provisional; Region: PRK14984 885275011055 gluconate transporter; Region: gntP; TIGR00791 885275011056 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 885275011057 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 885275011058 maltodextrin phosphorylase; Provisional; Region: PRK14985 885275011059 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 885275011060 homodimer interface [polypeptide binding]; other site 885275011061 active site pocket [active] 885275011062 transcriptional regulator MalT; Provisional; Region: PRK04841 885275011063 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885275011064 DNA binding residues [nucleotide binding] 885275011065 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 885275011066 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 885275011067 putative active site [active] 885275011068 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 885275011069 hypothetical protein; Reviewed; Region: PRK09588 885275011070 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 885275011071 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 885275011072 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275011073 Walker A motif; other site 885275011074 ATP binding site [chemical binding]; other site 885275011075 Walker B motif; other site 885275011076 arginine finger; other site 885275011077 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 885275011078 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 885275011079 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 885275011080 intramembrane serine protease GlpG; Provisional; Region: PRK10907 885275011081 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 885275011082 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 885275011083 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 885275011084 active site residue [active] 885275011085 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 885275011086 hypothetical protein; Provisional; Region: PRK09781; cl08057 885275011087 Fimbrial protein; Region: Fimbrial; cl01416 885275011088 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 885275011089 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 885275011090 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 885275011091 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 885275011092 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 885275011093 outer membrane usher protein; Provisional; Region: PRK15193 885275011094 PapC N-terminal domain; Region: PapC_N; pfam13954 885275011095 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 885275011096 PapC C-terminal domain; Region: PapC_C; pfam13953 885275011097 fimbrial chaperone protein StiB; Provisional; Region: PRK15299 885275011098 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 885275011099 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 885275011100 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 885275011101 glycogen phosphorylase; Provisional; Region: PRK14986 885275011102 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 885275011103 homodimer interface [polypeptide binding]; other site 885275011104 active site pocket [active] 885275011105 glycogen synthase; Provisional; Region: glgA; PRK00654 885275011106 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 885275011107 ADP-binding pocket [chemical binding]; other site 885275011108 homodimer interface [polypeptide binding]; other site 885275011109 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 885275011110 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 885275011111 ligand binding site; other site 885275011112 oligomer interface; other site 885275011113 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 885275011114 sulfate 1 binding site; other site 885275011115 glycogen debranching enzyme; Provisional; Region: PRK03705 885275011116 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 885275011117 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 885275011118 active site 885275011119 catalytic site [active] 885275011120 glycogen branching enzyme; Provisional; Region: PRK05402 885275011121 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 885275011122 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 885275011123 active site 885275011124 catalytic site [active] 885275011125 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 885275011126 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 885275011127 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 885275011128 putative antibiotic transporter; Provisional; Region: PRK10739 885275011129 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 885275011130 DNA protecting protein DprA; Region: dprA; TIGR00732 885275011131 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 885275011132 non-specific DNA interactions [nucleotide binding]; other site 885275011133 DNA binding site [nucleotide binding] 885275011134 sequence specific DNA binding site [nucleotide binding]; other site 885275011135 putative cAMP binding site [chemical binding]; other site 885275011136 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 885275011137 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 885275011138 ATP binding site [chemical binding]; other site 885275011139 putative Mg++ binding site [ion binding]; other site 885275011140 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 885275011141 nucleotide binding region [chemical binding]; other site 885275011142 ATP-binding site [chemical binding]; other site 885275011143 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 885275011144 active site 885275011145 low affinity gluconate transporter; Provisional; Region: PRK10472 885275011146 gluconate transporter; Region: gntP; TIGR00791 885275011147 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 885275011148 ATP-binding site [chemical binding]; other site 885275011149 Gluconate-6-phosphate binding site [chemical binding]; other site 885275011150 Shikimate kinase; Region: SKI; pfam01202 885275011151 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 885275011152 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 885275011153 DNA binding site [nucleotide binding] 885275011154 domain linker motif; other site 885275011155 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 885275011156 putative ligand binding site [chemical binding]; other site 885275011157 putative dimerization interface [polypeptide binding]; other site 885275011158 Pirin-related protein [General function prediction only]; Region: COG1741 885275011159 Pirin; Region: Pirin; pfam02678 885275011160 putative oxidoreductase; Provisional; Region: PRK10206 885275011161 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 885275011162 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 885275011163 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 885275011164 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 885275011165 YopJ Serine/Threonine acetyltransferase; Region: YopJ; cl07849 885275011166 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 885275011167 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 885275011168 hypothetical protein; Provisional; Region: PRK10350 885275011169 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 885275011170 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 885275011171 putative active site [active] 885275011172 catalytic site [active] 885275011173 putative metal binding site [ion binding]; other site 885275011174 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 885275011175 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 885275011176 Walker A/P-loop; other site 885275011177 ATP binding site [chemical binding]; other site 885275011178 Q-loop/lid; other site 885275011179 ABC transporter signature motif; other site 885275011180 Walker B; other site 885275011181 D-loop; other site 885275011182 H-loop/switch region; other site 885275011183 TOBE domain; Region: TOBE_2; pfam08402 885275011184 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 885275011185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275011186 dimer interface [polypeptide binding]; other site 885275011187 conserved gate region; other site 885275011188 putative PBP binding loops; other site 885275011189 ABC-ATPase subunit interface; other site 885275011190 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 885275011191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275011192 dimer interface [polypeptide binding]; other site 885275011193 conserved gate region; other site 885275011194 putative PBP binding loops; other site 885275011195 ABC-ATPase subunit interface; other site 885275011196 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 885275011197 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 885275011198 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 885275011199 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 885275011200 Walker A/P-loop; other site 885275011201 ATP binding site [chemical binding]; other site 885275011202 Q-loop/lid; other site 885275011203 ABC transporter signature motif; other site 885275011204 Walker B; other site 885275011205 D-loop; other site 885275011206 H-loop/switch region; other site 885275011207 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 885275011208 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 885275011209 Walker A/P-loop; other site 885275011210 ATP binding site [chemical binding]; other site 885275011211 Q-loop/lid; other site 885275011212 ABC transporter signature motif; other site 885275011213 Walker B; other site 885275011214 D-loop; other site 885275011215 H-loop/switch region; other site 885275011216 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 885275011217 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 885275011218 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 885275011219 TM-ABC transporter signature motif; other site 885275011220 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 885275011221 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 885275011222 TM-ABC transporter signature motif; other site 885275011223 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 885275011224 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 885275011225 dimerization interface [polypeptide binding]; other site 885275011226 ligand binding site [chemical binding]; other site 885275011227 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 885275011228 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 885275011229 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 885275011230 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 885275011231 dimerization interface [polypeptide binding]; other site 885275011232 ligand binding site [chemical binding]; other site 885275011233 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 885275011234 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 885275011235 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 885275011236 DNA binding residues [nucleotide binding] 885275011237 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 885275011238 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 885275011239 cell division protein FtsE; Provisional; Region: PRK10908 885275011240 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885275011241 Walker A/P-loop; other site 885275011242 ATP binding site [chemical binding]; other site 885275011243 Q-loop/lid; other site 885275011244 ABC transporter signature motif; other site 885275011245 Walker B; other site 885275011246 D-loop; other site 885275011247 H-loop/switch region; other site 885275011248 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 885275011249 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 885275011250 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 885275011251 P loop; other site 885275011252 GTP binding site [chemical binding]; other site 885275011253 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 885275011254 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275011255 S-adenosylmethionine binding site [chemical binding]; other site 885275011256 hypothetical protein; Provisional; Region: PRK10910 885275011257 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 885275011258 Predicted membrane protein [Function unknown]; Region: COG3714 885275011259 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 885275011260 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 885275011261 metal-binding site [ion binding] 885275011262 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 885275011263 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 885275011264 CPxP motif; other site 885275011265 hypothetical protein; Provisional; Region: PRK11212 885275011266 hypothetical protein; Provisional; Region: PRK11615 885275011267 major facilitator superfamily transporter; Provisional; Region: PRK05122 885275011268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275011269 putative substrate translocation pore; other site 885275011270 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 885275011271 Domain of unknown function DUF20; Region: UPF0118; pfam01594 885275011272 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 885275011273 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 885275011274 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 885275011275 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 885275011276 substrate binding site [chemical binding]; other site 885275011277 nickel transporter permease NikB; Provisional; Region: PRK10352 885275011278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275011279 dimer interface [polypeptide binding]; other site 885275011280 conserved gate region; other site 885275011281 putative PBP binding loops; other site 885275011282 ABC-ATPase subunit interface; other site 885275011283 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 885275011284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275011285 dimer interface [polypeptide binding]; other site 885275011286 conserved gate region; other site 885275011287 putative PBP binding loops; other site 885275011288 ABC-ATPase subunit interface; other site 885275011289 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 885275011290 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 885275011291 Walker A/P-loop; other site 885275011292 ATP binding site [chemical binding]; other site 885275011293 Q-loop/lid; other site 885275011294 ABC transporter signature motif; other site 885275011295 Walker B; other site 885275011296 D-loop; other site 885275011297 H-loop/switch region; other site 885275011298 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 885275011299 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 885275011300 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 885275011301 Walker A/P-loop; other site 885275011302 ATP binding site [chemical binding]; other site 885275011303 Q-loop/lid; other site 885275011304 ABC transporter signature motif; other site 885275011305 Walker B; other site 885275011306 D-loop; other site 885275011307 H-loop/switch region; other site 885275011308 nickel responsive regulator; Provisional; Region: PRK02967 885275011309 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 885275011310 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 885275011311 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885275011312 DNA-binding site [nucleotide binding]; DNA binding site 885275011313 UTRA domain; Region: UTRA; pfam07702 885275011314 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 885275011315 active site 885275011316 phosphorylation site [posttranslational modification] 885275011317 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 885275011318 active site 885275011319 P-loop; other site 885275011320 phosphorylation site [posttranslational modification] 885275011321 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 885275011322 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 885275011323 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 885275011324 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 885275011325 putative N- and C-terminal domain interface [polypeptide binding]; other site 885275011326 putative active site [active] 885275011327 putative MgATP binding site [chemical binding]; other site 885275011328 catalytic site [active] 885275011329 metal binding site [ion binding]; metal-binding site 885275011330 putative carbohydrate binding site [chemical binding]; other site 885275011331 seadornavirus RNA-directed RNA polymerase; Region: seadorna_RNAP; TIGR04234 885275011332 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 885275011333 dimerization domain swap beta strand [polypeptide binding]; other site 885275011334 regulatory protein interface [polypeptide binding]; other site 885275011335 active site 885275011336 regulatory phosphorylation site [posttranslational modification]; other site 885275011337 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 885275011338 intersubunit interface [polypeptide binding]; other site 885275011339 active site 885275011340 zinc binding site [ion binding]; other site 885275011341 Na+ binding site [ion binding]; other site 885275011342 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 885275011343 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 885275011344 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 885275011345 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 885275011346 Walker A/P-loop; other site 885275011347 ATP binding site [chemical binding]; other site 885275011348 Q-loop/lid; other site 885275011349 ABC transporter signature motif; other site 885275011350 Walker B; other site 885275011351 D-loop; other site 885275011352 H-loop/switch region; other site 885275011353 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 885275011354 Walker A/P-loop; other site 885275011355 ATP binding site [chemical binding]; other site 885275011356 Q-loop/lid; other site 885275011357 ABC transporter signature motif; other site 885275011358 Walker B; other site 885275011359 D-loop; other site 885275011360 H-loop/switch region; other site 885275011361 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 885275011362 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 885275011363 HlyD family secretion protein; Region: HlyD; pfam00529 885275011364 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885275011365 HlyD family secretion protein; Region: HlyD_3; pfam13437 885275011366 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 885275011367 Predicted flavoproteins [General function prediction only]; Region: COG2081 885275011368 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 885275011369 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 885275011370 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 885275011371 universal stress protein UspB; Provisional; Region: PRK04960 885275011372 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 885275011373 Ligand Binding Site [chemical binding]; other site 885275011374 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 885275011375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275011376 POT family; Region: PTR2; pfam00854 885275011377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275011378 S-adenosylmethionine binding site [chemical binding]; other site 885275011379 oligopeptidase A; Provisional; Region: PRK10911 885275011380 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 885275011381 active site 885275011382 Zn binding site [ion binding]; other site 885275011383 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 885275011384 glutathione reductase; Validated; Region: PRK06116 885275011385 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 885275011386 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 885275011387 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 885275011388 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 885275011389 ArsC family; Region: ArsC; pfam03960 885275011390 catalytic residues [active] 885275011391 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 885275011392 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 885275011393 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885275011394 DNA binding residues [nucleotide binding] 885275011395 dimerization interface [polypeptide binding]; other site 885275011396 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 885275011397 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 885275011398 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 885275011399 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 885275011400 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885275011401 N-terminal plug; other site 885275011402 ligand-binding site [chemical binding]; other site 885275011403 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 885275011404 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 885275011405 putative hemin binding site; other site 885275011406 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 885275011407 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885275011408 FeS/SAM binding site; other site 885275011409 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721 885275011410 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 885275011411 NADH(P)-binding; Region: NAD_binding_10; pfam13460 885275011412 NAD(P) binding site [chemical binding]; other site 885275011413 putative active site [active] 885275011414 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 885275011415 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 885275011416 ABC-ATPase subunit interface; other site 885275011417 dimer interface [polypeptide binding]; other site 885275011418 putative PBP binding regions; other site 885275011419 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 885275011420 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 885275011421 Walker A/P-loop; other site 885275011422 ATP binding site [chemical binding]; other site 885275011423 Q-loop/lid; other site 885275011424 ABC transporter signature motif; other site 885275011425 Walker B; other site 885275011426 D-loop; other site 885275011427 H-loop/switch region; other site 885275011428 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 885275011429 MgtC family; Region: MgtC; pfam02308 885275011430 acid-resistance protein; Provisional; Region: hdeB; PRK11566 885275011431 acid-resistance protein; Provisional; Region: PRK10208 885275011432 acid-resistance membrane protein; Provisional; Region: PRK10209 885275011433 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 885275011434 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 885275011435 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 885275011436 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885275011437 HlyD family secretion protein; Region: HlyD_3; pfam13437 885275011438 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 885275011439 Protein export membrane protein; Region: SecD_SecF; cl14618 885275011440 transcriptional regulator YdeO; Provisional; Region: PRK09940 885275011441 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275011442 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 885275011443 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275011444 catalytic residue [active] 885275011445 Haem-binding domain; Region: Haem_bd; pfam14376 885275011446 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 885275011447 trehalase; Provisional; Region: treF; PRK13270 885275011448 Trehalase; Region: Trehalase; pfam01204 885275011449 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 885275011450 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885275011451 DNA binding residues [nucleotide binding] 885275011452 dimerization interface [polypeptide binding]; other site 885275011453 Transcriptional regulator [Transcription]; Region: LysR; COG0583 885275011454 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275011455 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 885275011456 putative effector binding pocket; other site 885275011457 putative dimerization interface [polypeptide binding]; other site 885275011458 inner membrane protein YhjD; Region: TIGR00766 885275011459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275011460 metabolite-proton symporter; Region: 2A0106; TIGR00883 885275011461 putative substrate translocation pore; other site 885275011462 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 885275011463 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 885275011464 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885275011465 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 885275011466 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 885275011467 substrate binding site [chemical binding]; other site 885275011468 ATP binding site [chemical binding]; other site 885275011469 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 885275011470 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 885275011471 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 885275011472 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 885275011473 putative diguanylate cyclase; Provisional; Region: PRK13561 885275011474 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885275011475 metal binding site [ion binding]; metal-binding site 885275011476 active site 885275011477 I-site; other site 885275011478 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885275011479 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 885275011480 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 885275011481 binding surface 885275011482 TPR motif; other site 885275011483 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 885275011484 binding surface 885275011485 TPR motif; other site 885275011486 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 885275011487 TPR motif; other site 885275011488 binding surface 885275011489 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 885275011490 endo-1,4-D-glucanase; Provisional; Region: PRK11097 885275011491 cellulose synthase regulator protein; Provisional; Region: PRK11114 885275011492 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 885275011493 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 885275011494 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 885275011495 DXD motif; other site 885275011496 PilZ domain; Region: PilZ; pfam07238 885275011497 cell division protein; Provisional; Region: PRK10037 885275011498 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 885275011499 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 885275011500 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 885275011501 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 885275011502 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 885275011503 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 885275011504 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 885275011505 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 885275011506 serine transporter; Region: stp; TIGR00814 885275011507 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 885275011508 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 885275011509 Walker A/P-loop; other site 885275011510 ATP binding site [chemical binding]; other site 885275011511 Q-loop/lid; other site 885275011512 ABC transporter signature motif; other site 885275011513 Walker B; other site 885275011514 D-loop; other site 885275011515 H-loop/switch region; other site 885275011516 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 885275011517 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 885275011518 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 885275011519 Walker A/P-loop; other site 885275011520 ATP binding site [chemical binding]; other site 885275011521 Q-loop/lid; other site 885275011522 ABC transporter signature motif; other site 885275011523 Walker B; other site 885275011524 D-loop; other site 885275011525 H-loop/switch region; other site 885275011526 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 885275011527 dipeptide transporter; Provisional; Region: PRK10913 885275011528 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 885275011529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275011530 dimer interface [polypeptide binding]; other site 885275011531 conserved gate region; other site 885275011532 putative PBP binding loops; other site 885275011533 ABC-ATPase subunit interface; other site 885275011534 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 885275011535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275011536 dimer interface [polypeptide binding]; other site 885275011537 conserved gate region; other site 885275011538 putative PBP binding loops; other site 885275011539 ABC-ATPase subunit interface; other site 885275011540 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 885275011541 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 885275011542 peptide binding site [polypeptide binding]; other site 885275011543 phosphoethanolamine transferase; Provisional; Region: PRK11560 885275011544 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 885275011545 Sulfatase; Region: Sulfatase; pfam00884 885275011546 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 885275011547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275011548 putative substrate translocation pore; other site 885275011549 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 885275011550 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 885275011551 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 885275011552 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 885275011553 Coenzyme A binding pocket [chemical binding]; other site 885275011554 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 885275011555 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 885275011556 molybdopterin cofactor binding site [chemical binding]; other site 885275011557 substrate binding site [chemical binding]; other site 885275011558 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 885275011559 molybdopterin cofactor binding site; other site 885275011560 putative outer membrane lipoprotein; Provisional; Region: PRK10510 885275011561 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 885275011562 ligand binding site [chemical binding]; other site 885275011563 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 885275011564 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 885275011565 dimerization interface [polypeptide binding]; other site 885275011566 ligand binding site [chemical binding]; other site 885275011567 NADP binding site [chemical binding]; other site 885275011568 catalytic site [active] 885275011569 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 885275011570 Predicted transcriptional regulator [Transcription]; Region: COG2944 885275011571 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 885275011572 non-specific DNA binding site [nucleotide binding]; other site 885275011573 salt bridge; other site 885275011574 sequence-specific DNA binding site [nucleotide binding]; other site 885275011575 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 885275011576 DNA-binding site [nucleotide binding]; DNA binding site 885275011577 RNA-binding motif; other site 885275011578 small toxic polypeptide; Provisional; Region: PRK09759 885275011579 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 885275011580 DALR anticodon binding domain; Region: DALR_1; pfam05746 885275011581 anticodon binding site; other site 885275011582 tRNA binding surface [nucleotide binding]; other site 885275011583 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 885275011584 dimer interface [polypeptide binding]; other site 885275011585 motif 1; other site 885275011586 active site 885275011587 motif 2; other site 885275011588 motif 3; other site 885275011589 YsaB-like lipoprotein; Region: YsaB; pfam13983 885275011590 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 885275011591 Acyltransferase family; Region: Acyl_transf_3; pfam01757 885275011592 hypothetical protein; Provisional; Region: PRK11383 885275011593 yiaA/B two helix domain; Region: YiaAB; pfam05360 885275011594 yiaA/B two helix domain; Region: YiaAB; pfam05360 885275011595 hypothetical protein; Provisional; Region: PRK11403 885275011596 yiaA/B two helix domain; Region: YiaAB; pfam05360 885275011597 xylulokinase; Provisional; Region: PRK15027 885275011598 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 885275011599 N- and C-terminal domain interface [polypeptide binding]; other site 885275011600 active site 885275011601 MgATP binding site [chemical binding]; other site 885275011602 catalytic site [active] 885275011603 metal binding site [ion binding]; metal-binding site 885275011604 xylulose binding site [chemical binding]; other site 885275011605 homodimer interface [polypeptide binding]; other site 885275011606 xylose isomerase; Provisional; Region: PRK05474 885275011607 xylose isomerase; Region: xylose_isom_A; TIGR02630 885275011608 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 885275011609 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 885275011610 putative ligand binding site [chemical binding]; other site 885275011611 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 885275011612 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 885275011613 Walker A/P-loop; other site 885275011614 ATP binding site [chemical binding]; other site 885275011615 Q-loop/lid; other site 885275011616 ABC transporter signature motif; other site 885275011617 Walker B; other site 885275011618 D-loop; other site 885275011619 H-loop/switch region; other site 885275011620 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 885275011621 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 885275011622 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 885275011623 TM-ABC transporter signature motif; other site 885275011624 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 885275011625 putative dimerization interface [polypeptide binding]; other site 885275011626 Transcriptional regulators [Transcription]; Region: PurR; COG1609 885275011627 putative ligand binding site [chemical binding]; other site 885275011628 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275011629 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 885275011630 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275011631 hypothetical protein; Provisional; Region: PRK10356 885275011632 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 885275011633 alpha-amylase; Reviewed; Region: malS; PRK09505 885275011634 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 885275011635 active site 885275011636 catalytic site [active] 885275011637 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 885275011638 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 885275011639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275011640 homodimer interface [polypeptide binding]; other site 885275011641 catalytic residue [active] 885275011642 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 885275011643 Transcriptional regulator [Transcription]; Region: IclR; COG1414 885275011644 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 885275011645 Bacterial transcriptional regulator; Region: IclR; pfam01614 885275011646 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 885275011647 Domain of unknown function (DUF386); Region: DUF386; pfam04074 885275011648 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 885275011649 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 885275011650 DctM-like transporters; Region: DctM; pfam06808 885275011651 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 885275011652 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 885275011653 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 885275011654 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 885275011655 putative N- and C-terminal domain interface [polypeptide binding]; other site 885275011656 putative active site [active] 885275011657 MgATP binding site [chemical binding]; other site 885275011658 catalytic site [active] 885275011659 metal binding site [ion binding]; metal-binding site 885275011660 putative xylulose binding site [chemical binding]; other site 885275011661 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 885275011662 active site 885275011663 dimer interface [polypeptide binding]; other site 885275011664 magnesium binding site [ion binding]; other site 885275011665 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 885275011666 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 885275011667 AP (apurinic/apyrimidinic) site pocket; other site 885275011668 DNA interaction; other site 885275011669 Metal-binding active site; metal-binding site 885275011670 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 885275011671 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 885275011672 intersubunit interface [polypeptide binding]; other site 885275011673 active site 885275011674 Zn2+ binding site [ion binding]; other site 885275011675 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 885275011676 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 885275011677 NAD(P) binding site [chemical binding]; other site 885275011678 catalytic residues [active] 885275011679 Fic family protein [Function unknown]; Region: COG3177 885275011680 Fic/DOC family; Region: Fic; pfam02661 885275011681 putative alcohol dehydrogenase; Provisional; Region: PRK09860 885275011682 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 885275011683 dimer interface [polypeptide binding]; other site 885275011684 active site 885275011685 metal binding site [ion binding]; metal-binding site 885275011686 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 885275011687 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 885275011688 G1 box; other site 885275011689 putative GEF interaction site [polypeptide binding]; other site 885275011690 GTP/Mg2+ binding site [chemical binding]; other site 885275011691 Switch I region; other site 885275011692 G2 box; other site 885275011693 G3 box; other site 885275011694 Switch II region; other site 885275011695 G4 box; other site 885275011696 G5 box; other site 885275011697 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 885275011698 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 885275011699 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 885275011700 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 885275011701 selenocysteine synthase; Provisional; Region: PRK04311 885275011702 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 885275011703 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 885275011704 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 885275011705 catalytic residue [active] 885275011706 putative glutathione S-transferase; Provisional; Region: PRK10357 885275011707 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 885275011708 putative C-terminal domain interface [polypeptide binding]; other site 885275011709 putative GSH binding site (G-site) [chemical binding]; other site 885275011710 putative dimer interface [polypeptide binding]; other site 885275011711 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 885275011712 dimer interface [polypeptide binding]; other site 885275011713 N-terminal domain interface [polypeptide binding]; other site 885275011714 putative substrate binding pocket (H-site) [chemical binding]; other site 885275011715 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 885275011716 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885275011717 HlyD family secretion protein; Region: HlyD_3; pfam13437 885275011718 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 885275011719 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 885275011720 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 885275011721 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 885275011722 active site 885275011723 P-loop; other site 885275011724 phosphorylation site [posttranslational modification] 885275011725 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 885275011726 active site 885275011727 phosphorylation site [posttranslational modification] 885275011728 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 885275011729 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 885275011730 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 885275011731 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 885275011732 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 885275011733 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 885275011734 hypothetical protein; Provisional; Region: PRK11020 885275011735 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 885275011736 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 885275011737 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 885275011738 trimer interface [polypeptide binding]; other site 885275011739 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 885275011740 trimer interface [polypeptide binding]; other site 885275011741 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 885275011742 Haemagglutinin; Region: HIM; pfam05662 885275011743 Haemagglutinin; Region: HIM; pfam05662 885275011744 YadA-like C-terminal region; Region: YadA; pfam03895 885275011745 L-lactate permease; Provisional; Region: PRK10420 885275011746 glycolate transporter; Provisional; Region: PRK09695 885275011747 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 885275011748 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885275011749 DNA-binding site [nucleotide binding]; DNA binding site 885275011750 FCD domain; Region: FCD; pfam07729 885275011751 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 885275011752 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 885275011753 phosphate binding site [ion binding]; other site 885275011754 putative rRNA methylase; Provisional; Region: PRK10358 885275011755 serine acetyltransferase; Provisional; Region: cysE; PRK11132 885275011756 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 885275011757 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 885275011758 trimer interface [polypeptide binding]; other site 885275011759 active site 885275011760 substrate binding site [chemical binding]; other site 885275011761 CoA binding site [chemical binding]; other site 885275011762 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 885275011763 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 885275011764 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 885275011765 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 885275011766 SecA binding site; other site 885275011767 Preprotein binding site; other site 885275011768 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 885275011769 GSH binding site [chemical binding]; other site 885275011770 catalytic residues [active] 885275011771 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 885275011772 active site residue [active] 885275011773 phosphoglyceromutase; Provisional; Region: PRK05434 885275011774 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 885275011775 AmiB activator; Provisional; Region: PRK11637 885275011776 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 885275011777 Peptidase family M23; Region: Peptidase_M23; pfam01551 885275011778 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 885275011779 NodB motif; other site 885275011780 putative active site [active] 885275011781 putative catalytic site [active] 885275011782 Zn binding site [ion binding]; other site 885275011783 putative glycosyl transferase; Provisional; Region: PRK10073 885275011784 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 885275011785 active site 885275011786 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 885275011787 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 885275011788 NAD(P) binding site [chemical binding]; other site 885275011789 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 885275011790 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 885275011791 substrate-cofactor binding pocket; other site 885275011792 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275011793 catalytic residue [active] 885275011794 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 885275011795 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 885275011796 NADP binding site [chemical binding]; other site 885275011797 homopentamer interface [polypeptide binding]; other site 885275011798 substrate binding site [chemical binding]; other site 885275011799 active site 885275011800 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 885275011801 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 885275011802 putative active site [active] 885275011803 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 885275011804 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 885275011805 putative active site [active] 885275011806 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 885275011807 O-Antigen ligase; Region: Wzy_C; pfam04932 885275011808 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 885275011809 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 885275011810 active site 885275011811 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 885275011812 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 885275011813 Ligand binding site; other site 885275011814 metal-binding site 885275011815 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 885275011816 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 885275011817 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 885275011818 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 885275011819 Ligand binding site; other site 885275011820 metal-binding site 885275011821 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 885275011822 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 885275011823 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 885275011824 Ligand binding site; other site 885275011825 metal-binding site 885275011826 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 885275011827 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 885275011828 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 885275011829 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 885275011830 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 885275011831 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 885275011832 putative active site [active] 885275011833 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 885275011834 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 885275011835 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 885275011836 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 885275011837 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 885275011838 active site 885275011839 (T/H)XGH motif; other site 885275011840 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 885275011841 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 885275011842 DNA binding site [nucleotide binding] 885275011843 catalytic residue [active] 885275011844 H2TH interface [polypeptide binding]; other site 885275011845 putative catalytic residues [active] 885275011846 turnover-facilitating residue; other site 885275011847 intercalation triad [nucleotide binding]; other site 885275011848 8OG recognition residue [nucleotide binding]; other site 885275011849 putative reading head residues; other site 885275011850 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 885275011851 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 885275011852 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 885275011853 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 885275011854 hypothetical protein; Reviewed; Region: PRK00024 885275011855 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 885275011856 MPN+ (JAMM) motif; other site 885275011857 Zinc-binding site [ion binding]; other site 885275011858 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 885275011859 Flavoprotein; Region: Flavoprotein; pfam02441 885275011860 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 885275011861 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 885275011862 trimer interface [polypeptide binding]; other site 885275011863 active site 885275011864 division inhibitor protein; Provisional; Region: slmA; PRK09480 885275011865 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 885275011866 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 885275011867 active site 885275011868 ribonuclease PH; Reviewed; Region: rph; PRK00173 885275011869 Ribonuclease PH; Region: RNase_PH_bact; cd11362 885275011870 hexamer interface [polypeptide binding]; other site 885275011871 active site 885275011872 hypothetical protein; Provisional; Region: PRK11820 885275011873 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 885275011874 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 885275011875 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 885275011876 BRO family, N-terminal domain; Region: Bro-N; pfam02498 885275011877 Predicted membrane protein [Function unknown]; Region: COG2860 885275011878 UPF0126 domain; Region: UPF0126; pfam03458 885275011879 UPF0126 domain; Region: UPF0126; pfam03458 885275011880 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 885275011881 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 885275011882 nucleotide binding pocket [chemical binding]; other site 885275011883 K-X-D-G motif; other site 885275011884 catalytic site [active] 885275011885 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 885275011886 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 885275011887 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 885275011888 catalytic site [active] 885275011889 G-X2-G-X-G-K; other site 885275011890 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 885275011891 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 885275011892 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 885275011893 Zn2+ binding site [ion binding]; other site 885275011894 Mg2+ binding site [ion binding]; other site 885275011895 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 885275011896 synthetase active site [active] 885275011897 NTP binding site [chemical binding]; other site 885275011898 metal binding site [ion binding]; metal-binding site 885275011899 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 885275011900 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 885275011901 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 885275011902 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 885275011903 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 885275011904 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 885275011905 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 885275011906 generic binding surface II; other site 885275011907 ssDNA binding site; other site 885275011908 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 885275011909 ATP binding site [chemical binding]; other site 885275011910 putative Mg++ binding site [ion binding]; other site 885275011911 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 885275011912 nucleotide binding region [chemical binding]; other site 885275011913 ATP-binding site [chemical binding]; other site 885275011914 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 885275011915 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 885275011916 AsmA family; Region: AsmA; pfam05170 885275011917 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 885275011918 Protein of unknown function (DUF1498); Region: DUF1498; pfam07385 885275011919 fructokinase; Reviewed; Region: PRK09557 885275011920 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 885275011921 nucleotide binding site [chemical binding]; other site 885275011922 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 885275011923 intersubunit interface [polypeptide binding]; other site 885275011924 active site 885275011925 zinc binding site [ion binding]; other site 885275011926 Na+ binding site [ion binding]; other site 885275011927 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 885275011928 intersubunit interface [polypeptide binding]; other site 885275011929 active site 885275011930 zinc binding site [ion binding]; other site 885275011931 Na+ binding site [ion binding]; other site 885275011932 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 885275011933 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 885275011934 active site 885275011935 P-loop; other site 885275011936 phosphorylation site [posttranslational modification] 885275011937 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 885275011938 active site 885275011939 phosphorylation site [posttranslational modification] 885275011940 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 885275011941 HTH domain; Region: HTH_11; pfam08279 885275011942 Mga helix-turn-helix domain; Region: Mga; pfam05043 885275011943 PRD domain; Region: PRD; pfam00874 885275011944 PRD domain; Region: PRD; pfam00874 885275011945 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 885275011946 active site 885275011947 P-loop; other site 885275011948 phosphorylation site [posttranslational modification] 885275011949 putative alpha-glucosidase; Provisional; Region: PRK10658 885275011950 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 885275011951 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 885275011952 active site 885275011953 homotrimer interface [polypeptide binding]; other site 885275011954 catalytic site [active] 885275011955 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 885275011956 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 885275011957 putative transporter; Provisional; Region: PRK11462 885275011958 integrase; Provisional; Region: PRK09692 885275011959 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 885275011960 active site 885275011961 Int/Topo IB signature motif; other site 885275011962 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885275011963 Walker A/P-loop; other site 885275011964 ATP binding site [chemical binding]; other site 885275011965 Restriction endonuclease; Region: Mrr_cat; pfam04471 885275011966 Predicted transcriptional regulator [Transcription]; Region: COG2378 885275011967 WYL domain; Region: WYL; cl14852 885275011968 Predicted GTPase [General function prediction only]; Region: COG3596 885275011969 YfjP GTPase; Region: YfjP; cd11383 885275011970 G1 box; other site 885275011971 GTP/Mg2+ binding site [chemical binding]; other site 885275011972 Switch I region; other site 885275011973 G2 box; other site 885275011974 Switch II region; other site 885275011975 G3 box; other site 885275011976 G4 box; other site 885275011977 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 885275011978 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 885275011979 Domain of unknown function (DUF932); Region: DUF932; cl12129 885275011980 hypothetical protein; Reviewed; Region: PRK00024 885275011981 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 885275011982 MPN+ (JAMM) motif; other site 885275011983 Zinc-binding site [ion binding]; other site 885275011984 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 885275011985 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 885275011986 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885275011987 Walker A/P-loop; other site 885275011988 ATP binding site [chemical binding]; other site 885275011989 TIGR02646 family protein; Region: TIGR02646 885275011990 Virulence protein [General function prediction only]; Region: COG3943 885275011991 EamA-like transporter family; Region: EamA; pfam00892 885275011992 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 885275011993 EamA-like transporter family; Region: EamA; pfam00892 885275011994 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 885275011995 lipoprotein, YaeC family; Region: TIGR00363 885275011996 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 885275011997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275011998 putative substrate translocation pore; other site 885275011999 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 885275012000 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 885275012001 cryptic adenine deaminase; Provisional; Region: PRK10027 885275012002 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 885275012003 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 885275012004 active site 885275012005 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 885275012006 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 885275012007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275012008 putative substrate translocation pore; other site 885275012009 regulatory protein UhpC; Provisional; Region: PRK11663 885275012010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275012011 putative substrate translocation pore; other site 885275012012 sensory histidine kinase UhpB; Provisional; Region: PRK11644 885275012013 MASE1; Region: MASE1; pfam05231 885275012014 Histidine kinase; Region: HisKA_3; pfam07730 885275012015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275012016 ATP binding site [chemical binding]; other site 885275012017 Mg2+ binding site [ion binding]; other site 885275012018 G-X-G motif; other site 885275012019 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 885275012020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275012021 active site 885275012022 phosphorylation site [posttranslational modification] 885275012023 intermolecular recognition site; other site 885275012024 dimerization interface [polypeptide binding]; other site 885275012025 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885275012026 DNA binding residues [nucleotide binding] 885275012027 dimerization interface [polypeptide binding]; other site 885275012028 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 885275012029 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 885275012030 putative valine binding site [chemical binding]; other site 885275012031 dimer interface [polypeptide binding]; other site 885275012032 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 885275012033 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 885275012034 PYR/PP interface [polypeptide binding]; other site 885275012035 dimer interface [polypeptide binding]; other site 885275012036 TPP binding site [chemical binding]; other site 885275012037 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 885275012038 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 885275012039 TPP-binding site [chemical binding]; other site 885275012040 dimer interface [polypeptide binding]; other site 885275012041 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 885275012042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275012043 putative substrate translocation pore; other site 885275012044 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 885275012045 Domain of unknown function (DUF202); Region: DUF202; pfam02656 885275012046 Predicted membrane protein [Function unknown]; Region: COG2149 885275012047 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 885275012048 Sulfatase; Region: Sulfatase; pfam00884 885275012049 putative transporter; Provisional; Region: PRK10484 885275012050 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 885275012051 Na binding site [ion binding]; other site 885275012052 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 885275012053 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275012054 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 885275012055 putative transporter; Validated; Region: PRK03818 885275012056 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 885275012057 TrkA-C domain; Region: TrkA_C; pfam02080 885275012058 TrkA-C domain; Region: TrkA_C; pfam02080 885275012059 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 885275012060 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 885275012061 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 885275012062 putative dimer interface [polypeptide binding]; other site 885275012063 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 885275012064 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 885275012065 putative dimer interface [polypeptide binding]; other site 885275012066 hypothetical protein; Provisional; Region: PRK11616 885275012067 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 885275012068 putative oxidoreductase; Provisional; Region: PRK11445 885275012069 hypothetical protein; Provisional; Region: PRK07236 885275012070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275012071 D-galactonate transporter; Region: 2A0114; TIGR00893 885275012072 putative substrate translocation pore; other site 885275012073 galactonate dehydratase; Provisional; Region: PRK14017 885275012074 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 885275012075 putative active site pocket [active] 885275012076 putative metal binding site [ion binding]; other site 885275012077 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 885275012078 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 885275012079 active site 885275012080 intersubunit interface [polypeptide binding]; other site 885275012081 catalytic residue [active] 885275012082 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 885275012083 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 885275012084 Transcriptional regulators [Transcription]; Region: FadR; COG2186 885275012085 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885275012086 DNA-binding site [nucleotide binding]; DNA binding site 885275012087 FCD domain; Region: FCD; pfam07729 885275012088 hypothetical protein; Provisional; Region: PRK10215 885275012089 sugar phosphate phosphatase; Provisional; Region: PRK10513 885275012090 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885275012091 active site 885275012092 motif I; other site 885275012093 motif II; other site 885275012094 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885275012095 hypothetical protein; Provisional; Region: PRK11426 885275012096 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 885275012097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275012098 Mg2+ binding site [ion binding]; other site 885275012099 G-X-G motif; other site 885275012100 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 885275012101 anchoring element; other site 885275012102 dimer interface [polypeptide binding]; other site 885275012103 ATP binding site [chemical binding]; other site 885275012104 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 885275012105 active site 885275012106 putative metal-binding site [ion binding]; other site 885275012107 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 885275012108 recF protein; Region: recf; TIGR00611 885275012109 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885275012110 Walker A/P-loop; other site 885275012111 ATP binding site [chemical binding]; other site 885275012112 Q-loop/lid; other site 885275012113 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885275012114 ABC transporter signature motif; other site 885275012115 Walker B; other site 885275012116 D-loop; other site 885275012117 H-loop/switch region; other site 885275012118 DNA polymerase III subunit beta; Validated; Region: PRK05643 885275012119 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 885275012120 putative DNA binding surface [nucleotide binding]; other site 885275012121 dimer interface [polypeptide binding]; other site 885275012122 beta-clamp/clamp loader binding surface; other site 885275012123 beta-clamp/translesion DNA polymerase binding surface; other site 885275012124 DnaA N-terminal domain; Region: DnaA_N; pfam11638 885275012125 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 885275012126 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275012127 Walker A motif; other site 885275012128 ATP binding site [chemical binding]; other site 885275012129 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 885275012130 Walker B motif; other site 885275012131 arginine finger; other site 885275012132 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 885275012133 DnaA box-binding interface [nucleotide binding]; other site 885275012134 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 885275012135 ribonuclease P; Reviewed; Region: rnpA; PRK01732 885275012136 membrane protein insertase; Provisional; Region: PRK01318 885275012137 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 885275012138 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 885275012139 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 885275012140 trmE is a tRNA modification GTPase; Region: trmE; cd04164 885275012141 G1 box; other site 885275012142 GTP/Mg2+ binding site [chemical binding]; other site 885275012143 Switch I region; other site 885275012144 G2 box; other site 885275012145 Switch II region; other site 885275012146 G3 box; other site 885275012147 G4 box; other site 885275012148 G5 box; other site 885275012149 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 885275012150 Tryptophanese operon leader peptide; Region: Tna_leader; pfam08053 885275012151 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 885275012152 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 885275012153 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 885275012154 catalytic residue [active] 885275012155 tryptophan permease TnaB; Provisional; Region: PRK09664 885275012156 aromatic amino acid transport protein; Region: araaP; TIGR00837 885275012157 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 885275012158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275012159 putative substrate translocation pore; other site 885275012160 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 885275012161 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275012162 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 885275012163 substrate binding pocket [chemical binding]; other site 885275012164 dimerization interface [polypeptide binding]; other site 885275012165 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 885275012166 Predicted flavoprotein [General function prediction only]; Region: COG0431 885275012167 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 885275012168 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 885275012169 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 885275012170 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885275012171 active site 885275012172 motif I; other site 885275012173 motif II; other site 885275012174 putative inner membrane protein; Provisional; Region: PRK09823 885275012175 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 885275012176 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 885275012177 active site 885275012178 trimer interface [polypeptide binding]; other site 885275012179 allosteric site; other site 885275012180 active site lid [active] 885275012181 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 885275012182 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 885275012183 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 885275012184 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 885275012185 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 885275012186 trimer interface; other site 885275012187 sugar binding site [chemical binding]; other site 885275012188 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 885275012189 beta-galactosidase; Region: BGL; TIGR03356 885275012190 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 885275012191 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 885275012192 active site turn [active] 885275012193 phosphorylation site [posttranslational modification] 885275012194 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 885275012195 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 885275012196 HPr interaction site; other site 885275012197 glycerol kinase (GK) interaction site [polypeptide binding]; other site 885275012198 active site 885275012199 phosphorylation site [posttranslational modification] 885275012200 transcriptional antiterminator BglG; Provisional; Region: PRK09772 885275012201 CAT RNA binding domain; Region: CAT_RBD; pfam03123 885275012202 PRD domain; Region: PRD; pfam00874 885275012203 PRD domain; Region: PRD; pfam00874 885275012204 transcriptional regulator PhoU; Provisional; Region: PRK11115 885275012205 PhoU domain; Region: PhoU; pfam01895 885275012206 PhoU domain; Region: PhoU; pfam01895 885275012207 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 885275012208 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 885275012209 Walker A/P-loop; other site 885275012210 ATP binding site [chemical binding]; other site 885275012211 Q-loop/lid; other site 885275012212 ABC transporter signature motif; other site 885275012213 Walker B; other site 885275012214 D-loop; other site 885275012215 H-loop/switch region; other site 885275012216 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 885275012217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275012218 dimer interface [polypeptide binding]; other site 885275012219 conserved gate region; other site 885275012220 putative PBP binding loops; other site 885275012221 ABC-ATPase subunit interface; other site 885275012222 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 885275012223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275012224 dimer interface [polypeptide binding]; other site 885275012225 conserved gate region; other site 885275012226 putative PBP binding loops; other site 885275012227 ABC-ATPase subunit interface; other site 885275012228 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 885275012229 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 885275012230 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 885275012231 glutaminase active site [active] 885275012232 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 885275012233 dimer interface [polypeptide binding]; other site 885275012234 active site 885275012235 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 885275012236 dimer interface [polypeptide binding]; other site 885275012237 active site 885275012238 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 885275012239 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 885275012240 Substrate binding site; other site 885275012241 Mg++ binding site; other site 885275012242 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 885275012243 active site 885275012244 substrate binding site [chemical binding]; other site 885275012245 CoA binding site [chemical binding]; other site 885275012246 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 885275012247 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 885275012248 gamma subunit interface [polypeptide binding]; other site 885275012249 epsilon subunit interface [polypeptide binding]; other site 885275012250 LBP interface [polypeptide binding]; other site 885275012251 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 885275012252 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 885275012253 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 885275012254 alpha subunit interaction interface [polypeptide binding]; other site 885275012255 Walker A motif; other site 885275012256 ATP binding site [chemical binding]; other site 885275012257 Walker B motif; other site 885275012258 inhibitor binding site; inhibition site 885275012259 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 885275012260 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 885275012261 core domain interface [polypeptide binding]; other site 885275012262 delta subunit interface [polypeptide binding]; other site 885275012263 epsilon subunit interface [polypeptide binding]; other site 885275012264 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 885275012265 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 885275012266 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 885275012267 beta subunit interaction interface [polypeptide binding]; other site 885275012268 Walker A motif; other site 885275012269 ATP binding site [chemical binding]; other site 885275012270 Walker B motif; other site 885275012271 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 885275012272 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 885275012273 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 885275012274 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 885275012275 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 885275012276 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 885275012277 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 885275012278 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 885275012279 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 885275012280 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 885275012281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275012282 S-adenosylmethionine binding site [chemical binding]; other site 885275012283 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 885275012284 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 885275012285 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 885275012286 FMN-binding protein MioC; Provisional; Region: PRK09004 885275012287 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 885275012288 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 885275012289 putative DNA binding site [nucleotide binding]; other site 885275012290 putative Zn2+ binding site [ion binding]; other site 885275012291 AsnC family; Region: AsnC_trans_reg; pfam01037 885275012292 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 885275012293 dimer interface [polypeptide binding]; other site 885275012294 active site 885275012295 hypothetical protein; Provisional; Region: yieM; PRK10997 885275012296 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 885275012297 metal ion-dependent adhesion site (MIDAS); other site 885275012298 regulatory ATPase RavA; Provisional; Region: PRK13531 885275012299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275012300 Walker A motif; other site 885275012301 ATP binding site [chemical binding]; other site 885275012302 Walker B motif; other site 885275012303 arginine finger; other site 885275012304 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 885275012305 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 885275012306 potassium uptake protein; Region: kup; TIGR00794 885275012307 D-ribose pyranase; Provisional; Region: PRK11797 885275012308 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 885275012309 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 885275012310 Walker A/P-loop; other site 885275012311 ATP binding site [chemical binding]; other site 885275012312 Q-loop/lid; other site 885275012313 ABC transporter signature motif; other site 885275012314 Walker B; other site 885275012315 D-loop; other site 885275012316 H-loop/switch region; other site 885275012317 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 885275012318 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 885275012319 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 885275012320 TM-ABC transporter signature motif; other site 885275012321 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 885275012322 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 885275012323 ligand binding site [chemical binding]; other site 885275012324 dimerization interface [polypeptide binding]; other site 885275012325 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 885275012326 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 885275012327 substrate binding site [chemical binding]; other site 885275012328 dimer interface [polypeptide binding]; other site 885275012329 ATP binding site [chemical binding]; other site 885275012330 transcriptional repressor RbsR; Provisional; Region: PRK10423 885275012331 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 885275012332 DNA binding site [nucleotide binding] 885275012333 domain linker motif; other site 885275012334 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 885275012335 dimerization interface [polypeptide binding]; other site 885275012336 ligand binding site [chemical binding]; other site 885275012337 putative transporter; Provisional; Region: PRK10504 885275012338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275012339 putative substrate translocation pore; other site 885275012340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275012341 Transcriptional regulators [Transcription]; Region: FadR; COG2186 885275012342 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885275012343 DNA-binding site [nucleotide binding]; DNA binding site 885275012344 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 885275012345 transcriptional regulator HdfR; Provisional; Region: PRK03601 885275012346 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275012347 LysR substrate binding domain; Region: LysR_substrate; pfam03466 885275012348 dimerization interface [polypeptide binding]; other site 885275012349 hypothetical protein; Provisional; Region: PRK11027 885275012350 putative ATP-dependent protease; Provisional; Region: PRK09862 885275012351 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 885275012352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275012353 Walker A motif; other site 885275012354 ATP binding site [chemical binding]; other site 885275012355 Walker B motif; other site 885275012356 arginine finger; other site 885275012357 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 885275012358 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 885275012359 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 885275012360 PYR/PP interface [polypeptide binding]; other site 885275012361 dimer interface [polypeptide binding]; other site 885275012362 TPP binding site [chemical binding]; other site 885275012363 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 885275012364 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 885275012365 TPP-binding site [chemical binding]; other site 885275012366 dimer interface [polypeptide binding]; other site 885275012367 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 885275012368 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 885275012369 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 885275012370 homodimer interface [polypeptide binding]; other site 885275012371 substrate-cofactor binding pocket; other site 885275012372 catalytic residue [active] 885275012373 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 885275012374 threonine dehydratase; Reviewed; Region: PRK09224 885275012375 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 885275012376 tetramer interface [polypeptide binding]; other site 885275012377 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275012378 catalytic residue [active] 885275012379 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 885275012380 putative Ile/Val binding site [chemical binding]; other site 885275012381 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 885275012382 putative Ile/Val binding site [chemical binding]; other site 885275012383 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275012384 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 885275012385 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 885275012386 putative dimerization interface [polypeptide binding]; other site 885275012387 ketol-acid reductoisomerase; Validated; Region: PRK05225 885275012388 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 885275012389 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 885275012390 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 885275012391 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 885275012392 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 885275012393 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 885275012394 Part of AAA domain; Region: AAA_19; pfam13245 885275012395 Family description; Region: UvrD_C_2; pfam13538 885275012396 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 885275012397 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 885275012398 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 885275012399 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 885275012400 ATP binding site [chemical binding]; other site 885275012401 Mg++ binding site [ion binding]; other site 885275012402 motif III; other site 885275012403 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 885275012404 nucleotide binding region [chemical binding]; other site 885275012405 ATP-binding site [chemical binding]; other site 885275012406 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 885275012407 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 885275012408 catalytic residues [active] 885275012409 transcription termination factor Rho; Provisional; Region: rho; PRK09376 885275012410 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 885275012411 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 885275012412 RNA binding site [nucleotide binding]; other site 885275012413 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 885275012414 multimer interface [polypeptide binding]; other site 885275012415 Walker A motif; other site 885275012416 ATP binding site [chemical binding]; other site 885275012417 Walker B motif; other site 885275012418 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 885275012419 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 885275012420 Mg++ binding site [ion binding]; other site 885275012421 putative catalytic motif [active] 885275012422 substrate binding site [chemical binding]; other site 885275012423 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 885275012424 Chain length determinant protein; Region: Wzz; pfam02706 885275012425 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 885275012426 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 885275012427 active site 885275012428 homodimer interface [polypeptide binding]; other site 885275012429 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 885275012430 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 885275012431 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 885275012432 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 885275012433 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 885275012434 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 885275012435 NAD binding site [chemical binding]; other site 885275012436 substrate binding site [chemical binding]; other site 885275012437 homodimer interface [polypeptide binding]; other site 885275012438 active site 885275012439 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 885275012440 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 885275012441 substrate binding site; other site 885275012442 tetramer interface; other site 885275012443 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 885275012444 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 885275012445 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 885275012446 inhibitor-cofactor binding pocket; inhibition site 885275012447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275012448 catalytic residue [active] 885275012449 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 885275012450 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 885275012451 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 885275012452 putative common antigen polymerase; Provisional; Region: PRK02975 885275012453 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 885275012454 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 885275012455 putative transport protein YifK; Provisional; Region: PRK10746 885275012456 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 885275012457 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885275012458 FeS/SAM binding site; other site 885275012459 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 885275012460 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 885275012461 Sulfatase; Region: Sulfatase; pfam00884 885275012462 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 885275012463 HemY protein N-terminus; Region: HemY_N; pfam07219 885275012464 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 885275012465 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 885275012466 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 885275012467 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 885275012468 active site 885275012469 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 885275012470 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 885275012471 domain interfaces; other site 885275012472 active site 885275012473 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 885275012474 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 885275012475 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 885275012476 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 885275012477 putative iron binding site [ion binding]; other site 885275012478 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 885275012479 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 885275012480 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 885275012481 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 885275012482 hypothetical protein; Provisional; Region: PRK10963 885275012483 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 885275012484 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 885275012485 active site 885275012486 DNA binding site [nucleotide binding] 885275012487 Int/Topo IB signature motif; other site 885275012488 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 885275012489 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885275012490 motif II; other site 885275012491 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 885275012492 Part of AAA domain; Region: AAA_19; pfam13245 885275012493 Family description; Region: UvrD_C_2; pfam13538 885275012494 Uncharacterized conserved protein [Function unknown]; Region: COG1912 885275012495 Predicted periplasmic protein [Function unknown]; Region: COG3698 885275012496 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 885275012497 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 885275012498 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 885275012499 Cl binding site [ion binding]; other site 885275012500 oligomer interface [polypeptide binding]; other site 885275012501 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 885275012502 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 885275012503 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 885275012504 EamA-like transporter family; Region: EamA; cl17759 885275012505 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 885275012506 CoenzymeA binding site [chemical binding]; other site 885275012507 subunit interaction site [polypeptide binding]; other site 885275012508 PHB binding site; other site 885275012509 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 885275012510 dimerization interface [polypeptide binding]; other site 885275012511 substrate binding site [chemical binding]; other site 885275012512 active site 885275012513 calcium binding site [ion binding]; other site 885275012514 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 885275012515 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 885275012516 ATP binding site [chemical binding]; other site 885275012517 putative Mg++ binding site [ion binding]; other site 885275012518 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 885275012519 nucleotide binding region [chemical binding]; other site 885275012520 ATP-binding site [chemical binding]; other site 885275012521 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 885275012522 Helicase and RNase D C-terminal; Region: HRDC; smart00341 885275012523 threonine efflux system; Provisional; Region: PRK10229 885275012524 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 885275012525 lysophospholipase L2; Provisional; Region: PRK10749 885275012526 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 885275012527 putative hydrolase; Provisional; Region: PRK10976 885275012528 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885275012529 active site 885275012530 motif I; other site 885275012531 motif II; other site 885275012532 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885275012533 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 885275012534 EamA-like transporter family; Region: EamA; pfam00892 885275012535 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 885275012536 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275012537 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 885275012538 putative dimerization interface [polypeptide binding]; other site 885275012539 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 885275012540 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 885275012541 THF binding site; other site 885275012542 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 885275012543 substrate binding site [chemical binding]; other site 885275012544 THF binding site; other site 885275012545 zinc-binding site [ion binding]; other site 885275012546 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 885275012547 tetramer interface [polypeptide binding]; other site 885275012548 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 885275012549 active site 885275012550 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 885275012551 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 885275012552 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 885275012553 active site turn [active] 885275012554 phosphorylation site [posttranslational modification] 885275012555 transketolase; Reviewed; Region: PRK12753 885275012556 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 885275012557 TPP-binding site [chemical binding]; other site 885275012558 dimer interface [polypeptide binding]; other site 885275012559 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 885275012560 PYR/PP interface [polypeptide binding]; other site 885275012561 dimer interface [polypeptide binding]; other site 885275012562 TPP binding site [chemical binding]; other site 885275012563 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 885275012564 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 885275012565 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 885275012566 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 885275012567 putative active site [active] 885275012568 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 885275012569 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275012570 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 885275012571 dimerization interface [polypeptide binding]; other site 885275012572 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 885275012573 Na binding site [ion binding]; other site 885275012574 allophanate hydrolase; Provisional; Region: PRK08186 885275012575 carbamate kinase; Reviewed; Region: PRK12686 885275012576 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 885275012577 putative substrate binding site [chemical binding]; other site 885275012578 nucleotide binding site [chemical binding]; other site 885275012579 nucleotide binding site [chemical binding]; other site 885275012580 homodimer interface [polypeptide binding]; other site 885275012581 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 885275012582 CoA binding domain; Region: CoA_binding; pfam02629 885275012583 CoA-ligase; Region: Ligase_CoA; pfam00549 885275012584 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 885275012585 Isochorismatase family; Region: Isochorismatase; pfam00857 885275012586 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 885275012587 catalytic triad [active] 885275012588 conserved cis-peptide bond; other site 885275012589 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 885275012590 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 885275012591 uridine phosphorylase; Provisional; Region: PRK11178 885275012592 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 885275012593 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 885275012594 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 885275012595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 885275012596 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 885275012597 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 885275012598 active site 885275012599 intersubunit interface [polypeptide binding]; other site 885275012600 catalytic residue [active] 885275012601 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 885275012602 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 885275012603 Transcriptional regulator [Transcription]; Region: IclR; COG1414 885275012604 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 885275012605 Bacterial transcriptional regulator; Region: IclR; pfam01614 885275012606 DNA recombination protein RmuC; Provisional; Region: PRK10361 885275012607 RmuC family; Region: RmuC; pfam02646 885275012608 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 885275012609 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275012610 S-adenosylmethionine binding site [chemical binding]; other site 885275012611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 885275012612 SCP-2 sterol transfer family; Region: SCP2; pfam02036 885275012613 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 885275012614 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 885275012615 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 885275012616 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 885275012617 sec-independent translocase; Provisional; Region: PRK01770 885275012618 sec-independent translocase; Provisional; Region: tatB; PRK00404 885275012619 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 885275012620 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 885275012621 active site 885275012622 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 885275012623 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 885275012624 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 885275012625 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 885275012626 FMN reductase; Validated; Region: fre; PRK08051 885275012627 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 885275012628 FAD binding pocket [chemical binding]; other site 885275012629 FAD binding motif [chemical binding]; other site 885275012630 phosphate binding motif [ion binding]; other site 885275012631 beta-alpha-beta structure motif; other site 885275012632 NAD binding pocket [chemical binding]; other site 885275012633 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 885275012634 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 885275012635 dimer interface [polypeptide binding]; other site 885275012636 active site 885275012637 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 885275012638 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 885275012639 substrate binding site [chemical binding]; other site 885275012640 oxyanion hole (OAH) forming residues; other site 885275012641 trimer interface [polypeptide binding]; other site 885275012642 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 885275012643 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 885275012644 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 885275012645 proline dipeptidase; Provisional; Region: PRK13607 885275012646 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 885275012647 active site 885275012648 hypothetical protein; Provisional; Region: PRK11568 885275012649 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 885275012650 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 885275012651 potassium transporter; Provisional; Region: PRK10750 885275012652 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 885275012653 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 885275012654 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 885275012655 Walker A motif; other site 885275012656 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 885275012657 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 885275012658 GTP binding site; other site 885275012659 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 885275012660 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 885275012661 serine/threonine protein kinase; Provisional; Region: PRK11768 885275012662 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 885275012663 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 885275012664 catalytic residues [active] 885275012665 hinge region; other site 885275012666 alpha helical domain; other site 885275012667 hypothetical protein; Provisional; Region: PRK11367 885275012668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 885275012669 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 885275012670 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 885275012671 putative acyl-acceptor binding pocket; other site 885275012672 DNA polymerase I; Provisional; Region: PRK05755 885275012673 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 885275012674 active site 885275012675 metal binding site 1 [ion binding]; metal-binding site 885275012676 putative 5' ssDNA interaction site; other site 885275012677 metal binding site 3; metal-binding site 885275012678 metal binding site 2 [ion binding]; metal-binding site 885275012679 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 885275012680 putative DNA binding site [nucleotide binding]; other site 885275012681 putative metal binding site [ion binding]; other site 885275012682 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 885275012683 active site 885275012684 catalytic site [active] 885275012685 substrate binding site [chemical binding]; other site 885275012686 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 885275012687 active site 885275012688 DNA binding site [nucleotide binding] 885275012689 catalytic site [active] 885275012690 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 885275012691 G1 box; other site 885275012692 GTP/Mg2+ binding site [chemical binding]; other site 885275012693 Switch I region; other site 885275012694 G2 box; other site 885275012695 G3 box; other site 885275012696 Switch II region; other site 885275012697 G4 box; other site 885275012698 G5 box; other site 885275012699 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 885275012700 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 885275012701 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885275012702 FeS/SAM binding site; other site 885275012703 HemN C-terminal domain; Region: HemN_C; pfam06969 885275012704 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 885275012705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275012706 active site 885275012707 phosphorylation site [posttranslational modification] 885275012708 intermolecular recognition site; other site 885275012709 dimerization interface [polypeptide binding]; other site 885275012710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275012711 Walker A motif; other site 885275012712 ATP binding site [chemical binding]; other site 885275012713 Walker B motif; other site 885275012714 arginine finger; other site 885275012715 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 885275012716 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 885275012717 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 885275012718 putative active site [active] 885275012719 heme pocket [chemical binding]; other site 885275012720 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885275012721 dimer interface [polypeptide binding]; other site 885275012722 phosphorylation site [posttranslational modification] 885275012723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275012724 ATP binding site [chemical binding]; other site 885275012725 Mg2+ binding site [ion binding]; other site 885275012726 G-X-G motif; other site 885275012727 glutamine synthetase; Provisional; Region: glnA; PRK09469 885275012728 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 885275012729 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 885275012730 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 885275012731 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 885275012732 G1 box; other site 885275012733 putative GEF interaction site [polypeptide binding]; other site 885275012734 GTP/Mg2+ binding site [chemical binding]; other site 885275012735 Switch I region; other site 885275012736 G2 box; other site 885275012737 G3 box; other site 885275012738 Switch II region; other site 885275012739 G4 box; other site 885275012740 G5 box; other site 885275012741 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 885275012742 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 885275012743 transcriptional regulator protein; Region: phnR; TIGR03337 885275012744 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885275012745 DNA-binding site [nucleotide binding]; DNA binding site 885275012746 UTRA domain; Region: UTRA; pfam07702 885275012747 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 885275012748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275012749 putative substrate translocation pore; other site 885275012750 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 885275012751 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 885275012752 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 885275012753 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 885275012754 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 885275012755 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 885275012756 substrate binding site [chemical binding]; other site 885275012757 ATP binding site [chemical binding]; other site 885275012758 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 885275012759 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 885275012760 Class I aldolases; Region: Aldolase_Class_I; cl17187 885275012761 catalytic residue [active] 885275012762 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 885275012763 putative oxidoreductase; Provisional; Region: PRK10083 885275012764 NAD(P) binding site [chemical binding]; other site 885275012765 benzoate transport; Region: 2A0115; TIGR00895 885275012766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275012767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275012768 shikimate transporter; Provisional; Region: PRK09952 885275012769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275012770 putative substrate translocation pore; other site 885275012771 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 885275012772 active site 885275012773 catalytic residues [active] 885275012774 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 885275012775 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885275012776 motif II; other site 885275012777 hypothetical protein; Reviewed; Region: PRK01637 885275012778 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 885275012779 putative active site [active] 885275012780 dimerization interface [polypeptide binding]; other site 885275012781 putative tRNAtyr binding site [nucleotide binding]; other site 885275012782 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 885275012783 Coenzyme A binding pocket [chemical binding]; other site 885275012784 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 885275012785 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 885275012786 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 885275012787 substrate binding pocket [chemical binding]; other site 885275012788 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 885275012789 non-specific DNA binding site [nucleotide binding]; other site 885275012790 salt bridge; other site 885275012791 sequence-specific DNA binding site [nucleotide binding]; other site 885275012792 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 885275012793 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 885275012794 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 885275012795 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 885275012796 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 885275012797 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 885275012798 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 885275012799 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 885275012800 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 885275012801 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 885275012802 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 885275012803 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 885275012804 intersubunit interface [polypeptide binding]; other site 885275012805 active site 885275012806 Zn2+ binding site [ion binding]; other site 885275012807 L-rhamnose isomerase; Provisional; Region: PRK01076 885275012808 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 885275012809 N- and C-terminal domain interface [polypeptide binding]; other site 885275012810 active site 885275012811 putative catalytic site [active] 885275012812 metal binding site [ion binding]; metal-binding site 885275012813 ATP binding site [chemical binding]; other site 885275012814 rhamnulokinase; Provisional; Region: rhaB; PRK10640 885275012815 carbohydrate binding site [chemical binding]; other site 885275012816 transcriptional activator RhaS; Provisional; Region: PRK13503 885275012817 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 885275012818 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275012819 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275012820 transcriptional activator RhaR; Provisional; Region: PRK13500 885275012821 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 885275012822 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275012823 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275012824 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 885275012825 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 885275012826 superoxide dismutase; Provisional; Region: PRK10925 885275012827 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 885275012828 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 885275012829 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 885275012830 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 885275012831 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 885275012832 MOSC domain; Region: MOSC; pfam03473 885275012833 3-alpha domain; Region: 3-alpha; pfam03475 885275012834 two-component sensor protein; Provisional; Region: cpxA; PRK09470 885275012835 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 885275012836 dimerization interface [polypeptide binding]; other site 885275012837 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885275012838 dimer interface [polypeptide binding]; other site 885275012839 phosphorylation site [posttranslational modification] 885275012840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275012841 ATP binding site [chemical binding]; other site 885275012842 Mg2+ binding site [ion binding]; other site 885275012843 G-X-G motif; other site 885275012844 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 885275012845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275012846 active site 885275012847 intermolecular recognition site; other site 885275012848 dimerization interface [polypeptide binding]; other site 885275012849 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 885275012850 DNA binding site [nucleotide binding] 885275012851 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 885275012852 dimer interface [polypeptide binding]; other site 885275012853 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 885275012854 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 885275012855 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 885275012856 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 885275012857 active site 885275012858 ADP/pyrophosphate binding site [chemical binding]; other site 885275012859 dimerization interface [polypeptide binding]; other site 885275012860 allosteric effector site; other site 885275012861 fructose-1,6-bisphosphate binding site; other site 885275012862 sulfate transporter subunit; Provisional; Region: PRK10752 885275012863 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 885275012864 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 885275012865 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 885275012866 triosephosphate isomerase; Provisional; Region: PRK14567 885275012867 substrate binding site [chemical binding]; other site 885275012868 dimer interface [polypeptide binding]; other site 885275012869 catalytic triad [active] 885275012870 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 885275012871 Predicted membrane protein [Function unknown]; Region: COG3152 885275012872 hypothetical protein; Provisional; Region: PRK09981 885275012873 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 885275012874 Ligand Binding Site [chemical binding]; other site 885275012875 ferredoxin-NADP reductase; Provisional; Region: PRK10926 885275012876 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 885275012877 FAD binding pocket [chemical binding]; other site 885275012878 FAD binding motif [chemical binding]; other site 885275012879 phosphate binding motif [ion binding]; other site 885275012880 beta-alpha-beta structure motif; other site 885275012881 NAD binding pocket [chemical binding]; other site 885275012882 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 885275012883 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 885275012884 putative active site [active] 885275012885 glycerol kinase; Provisional; Region: glpK; PRK00047 885275012886 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 885275012887 N- and C-terminal domain interface [polypeptide binding]; other site 885275012888 active site 885275012889 MgATP binding site [chemical binding]; other site 885275012890 catalytic site [active] 885275012891 metal binding site [ion binding]; metal-binding site 885275012892 glycerol binding site [chemical binding]; other site 885275012893 homotetramer interface [polypeptide binding]; other site 885275012894 homodimer interface [polypeptide binding]; other site 885275012895 FBP binding site [chemical binding]; other site 885275012896 protein IIAGlc interface [polypeptide binding]; other site 885275012897 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 885275012898 amphipathic channel; other site 885275012899 Asn-Pro-Ala signature motifs; other site 885275012900 septal ring assembly protein ZapB; Provisional; Region: PRK15422 885275012901 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 885275012902 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 885275012903 UbiA prenyltransferase family; Region: UbiA; pfam01040 885275012904 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 885275012905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275012906 Walker A motif; other site 885275012907 ATP binding site [chemical binding]; other site 885275012908 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 885275012909 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 885275012910 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 885275012911 active site 885275012912 HslU subunit interaction site [polypeptide binding]; other site 885275012913 essential cell division protein FtsN; Provisional; Region: PRK10927 885275012914 cell division protein FtsN; Provisional; Region: PRK12757 885275012915 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 885275012916 DNA binding site [nucleotide binding] 885275012917 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 885275012918 domain linker motif; other site 885275012919 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 885275012920 dimerization interface [polypeptide binding]; other site 885275012921 ligand binding site [chemical binding]; other site 885275012922 primosome assembly protein PriA; Validated; Region: PRK05580 885275012923 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 885275012924 ATP binding site [chemical binding]; other site 885275012925 putative Mg++ binding site [ion binding]; other site 885275012926 helicase superfamily c-terminal domain; Region: HELICc; smart00490 885275012927 ATP-binding site [chemical binding]; other site 885275012928 hypothetical protein; Provisional; Region: PRK10030 885275012929 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 885275012930 dimerization interface [polypeptide binding]; other site 885275012931 DNA binding site [nucleotide binding] 885275012932 corepressor binding sites; other site 885275012933 cystathionine gamma-synthase; Provisional; Region: PRK08045 885275012934 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 885275012935 homodimer interface [polypeptide binding]; other site 885275012936 substrate-cofactor binding pocket; other site 885275012937 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275012938 catalytic residue [active] 885275012939 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 885275012940 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 885275012941 putative catalytic residues [active] 885275012942 putative nucleotide binding site [chemical binding]; other site 885275012943 putative aspartate binding site [chemical binding]; other site 885275012944 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 885275012945 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 885275012946 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 885275012947 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 885275012948 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 885275012949 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 885275012950 active site 885275012951 metal binding site [ion binding]; metal-binding site 885275012952 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 885275012953 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 885275012954 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 885275012955 active site 885275012956 metal binding site [ion binding]; metal-binding site 885275012957 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 885275012958 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 885275012959 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 885275012960 active site 885275012961 metal binding site [ion binding]; metal-binding site 885275012962 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 885275012963 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 885275012964 FAD binding site [chemical binding]; other site 885275012965 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 885275012966 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 885275012967 heme binding site [chemical binding]; other site 885275012968 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 885275012969 EamA-like transporter family; Region: EamA; pfam00892 885275012970 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 885275012971 EamA-like transporter family; Region: EamA; pfam00892 885275012972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 885275012973 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 885275012974 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 885275012975 dimer interface [polypeptide binding]; other site 885275012976 active site 885275012977 metal binding site [ion binding]; metal-binding site 885275012978 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 885275012979 active site 885275012980 intersubunit interactions; other site 885275012981 catalytic residue [active] 885275012982 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 885275012983 dimerization domain swap beta strand [polypeptide binding]; other site 885275012984 regulatory protein interface [polypeptide binding]; other site 885275012985 active site 885275012986 regulatory phosphorylation site [posttranslational modification]; other site 885275012987 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 885275012988 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 885275012989 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 885275012990 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 885275012991 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 885275012992 active site 885275012993 phosphorylation site [posttranslational modification] 885275012994 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 885275012995 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 885275012996 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 885275012997 active site 885275012998 P-loop; other site 885275012999 phosphorylation site [posttranslational modification] 885275013000 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 885275013001 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 885275013002 dimer interface [polypeptide binding]; other site 885275013003 active site 885275013004 glycine loop; other site 885275013005 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885275013006 FeS/SAM binding site; other site 885275013007 pyruvate formate lyase II activase; Provisional; Region: PRK10076 885275013008 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 885275013009 active site 885275013010 P-loop; other site 885275013011 phosphorylation site [posttranslational modification] 885275013012 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 885275013013 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275013014 hypothetical protein; Provisional; Region: PRK10649 885275013015 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 885275013016 Sulfatase; Region: Sulfatase; pfam00884 885275013017 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 885275013018 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 885275013019 acetylornithine deacetylase; Provisional; Region: PRK05111 885275013020 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 885275013021 metal binding site [ion binding]; metal-binding site 885275013022 putative dimer interface [polypeptide binding]; other site 885275013023 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 885275013024 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 885275013025 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 885275013026 nucleotide binding site [chemical binding]; other site 885275013027 N-acetyl-L-glutamate binding site [chemical binding]; other site 885275013028 argininosuccinate lyase; Provisional; Region: PRK04833 885275013029 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 885275013030 active sites [active] 885275013031 tetramer interface [polypeptide binding]; other site 885275013032 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 885275013033 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 885275013034 putative active site pocket [active] 885275013035 putative metal binding site [ion binding]; other site 885275013036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275013037 D-galactonate transporter; Region: 2A0114; TIGR00893 885275013038 putative substrate translocation pore; other site 885275013039 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 885275013040 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275013041 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 885275013042 dimerization interface [polypeptide binding]; other site 885275013043 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 885275013044 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 885275013045 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 885275013046 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 885275013047 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 885275013048 metal binding site [ion binding]; metal-binding site 885275013049 putative dimer interface [polypeptide binding]; other site 885275013050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275013051 metabolite-proton symporter; Region: 2A0106; TIGR00883 885275013052 putative substrate translocation pore; other site 885275013053 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 885275013054 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 885275013055 hypothetical protein; Provisional; Region: PRK11056 885275013056 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 885275013057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275013058 S-adenosylmethionine binding site [chemical binding]; other site 885275013059 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 885275013060 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885275013061 N-terminal plug; other site 885275013062 ligand-binding site [chemical binding]; other site 885275013063 glutamate racemase; Provisional; Region: PRK00865 885275013064 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 885275013065 FAD binding domain; Region: FAD_binding_4; pfam01565 885275013066 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 885275013067 Biotin operon repressor [Transcription]; Region: BirA; COG1654 885275013068 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 885275013069 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 885275013070 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 885275013071 pantothenate kinase; Provisional; Region: PRK05439 885275013072 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 885275013073 ATP-binding site [chemical binding]; other site 885275013074 CoA-binding site [chemical binding]; other site 885275013075 Mg2+-binding site [ion binding]; other site 885275013076 elongation factor Tu; Reviewed; Region: PRK00049 885275013077 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 885275013078 G1 box; other site 885275013079 GEF interaction site [polypeptide binding]; other site 885275013080 GTP/Mg2+ binding site [chemical binding]; other site 885275013081 Switch I region; other site 885275013082 G2 box; other site 885275013083 G3 box; other site 885275013084 Switch II region; other site 885275013085 G4 box; other site 885275013086 G5 box; other site 885275013087 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 885275013088 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 885275013089 Antibiotic Binding Site [chemical binding]; other site 885275013090 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 885275013091 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 885275013092 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 885275013093 putative homodimer interface [polypeptide binding]; other site 885275013094 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 885275013095 heterodimer interface [polypeptide binding]; other site 885275013096 homodimer interface [polypeptide binding]; other site 885275013097 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 885275013098 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 885275013099 23S rRNA interface [nucleotide binding]; other site 885275013100 L7/L12 interface [polypeptide binding]; other site 885275013101 putative thiostrepton binding site; other site 885275013102 L25 interface [polypeptide binding]; other site 885275013103 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 885275013104 mRNA/rRNA interface [nucleotide binding]; other site 885275013105 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 885275013106 23S rRNA interface [nucleotide binding]; other site 885275013107 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 885275013108 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 885275013109 core dimer interface [polypeptide binding]; other site 885275013110 peripheral dimer interface [polypeptide binding]; other site 885275013111 L10 interface [polypeptide binding]; other site 885275013112 L11 interface [polypeptide binding]; other site 885275013113 putative EF-Tu interaction site [polypeptide binding]; other site 885275013114 putative EF-G interaction site [polypeptide binding]; other site 885275013115 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 885275013116 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 885275013117 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 885275013118 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 885275013119 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 885275013120 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 885275013121 RPB3 interaction site [polypeptide binding]; other site 885275013122 RPB1 interaction site [polypeptide binding]; other site 885275013123 RPB11 interaction site [polypeptide binding]; other site 885275013124 RPB10 interaction site [polypeptide binding]; other site 885275013125 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 885275013126 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 885275013127 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 885275013128 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 885275013129 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 885275013130 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 885275013131 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 885275013132 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 885275013133 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 885275013134 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 885275013135 DNA binding site [nucleotide binding] 885275013136 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 885275013137 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 885275013138 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885275013139 FeS/SAM binding site; other site 885275013140 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 885275013141 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 885275013142 ThiS interaction site; other site 885275013143 putative active site [active] 885275013144 tetramer interface [polypeptide binding]; other site 885275013145 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 885275013146 thiS-thiF/thiG interaction site; other site 885275013147 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 885275013148 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 885275013149 ATP binding site [chemical binding]; other site 885275013150 substrate interface [chemical binding]; other site 885275013151 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 885275013152 thiamine phosphate binding site [chemical binding]; other site 885275013153 active site 885275013154 pyrophosphate binding site [ion binding]; other site 885275013155 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 885275013156 ThiC-associated domain; Region: ThiC-associated; pfam13667 885275013157 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 885275013158 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 885275013159 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 885275013160 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 885275013161 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 885275013162 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 885275013163 putative NADH binding site [chemical binding]; other site 885275013164 putative active site [active] 885275013165 nudix motif; other site 885275013166 putative metal binding site [ion binding]; other site 885275013167 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 885275013168 substrate binding site [chemical binding]; other site 885275013169 active site 885275013170 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 885275013171 Active_site [active] 885275013172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 885275013173 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 885275013174 IHF dimer interface [polypeptide binding]; other site 885275013175 IHF - DNA interface [nucleotide binding]; other site 885275013176 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 885275013177 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 885275013178 dimer interface [polypeptide binding]; other site 885275013179 sensor protein ZraS; Provisional; Region: PRK10364 885275013180 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885275013181 dimer interface [polypeptide binding]; other site 885275013182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275013183 ATP binding site [chemical binding]; other site 885275013184 Mg2+ binding site [ion binding]; other site 885275013185 G-X-G motif; other site 885275013186 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 885275013187 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275013188 active site 885275013189 phosphorylation site [posttranslational modification] 885275013190 intermolecular recognition site; other site 885275013191 dimerization interface [polypeptide binding]; other site 885275013192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275013193 Walker A motif; other site 885275013194 ATP binding site [chemical binding]; other site 885275013195 Walker B motif; other site 885275013196 arginine finger; other site 885275013197 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 885275013198 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 885275013199 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 885275013200 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 885275013201 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 885275013202 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 885275013203 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 885275013204 purine monophosphate binding site [chemical binding]; other site 885275013205 dimer interface [polypeptide binding]; other site 885275013206 putative catalytic residues [active] 885275013207 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 885275013208 hypothetical protein; Provisional; Region: PRK10039 885275013209 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 885275013210 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 885275013211 Coenzyme A binding pocket [chemical binding]; other site 885275013212 homoserine O-succinyltransferase; Provisional; Region: PRK05368 885275013213 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 885275013214 proposed active site lysine [active] 885275013215 conserved cys residue [active] 885275013216 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 885275013217 malate synthase A; Region: malate_syn_A; TIGR01344 885275013218 active site 885275013219 isocitrate lyase; Provisional; Region: PRK15063 885275013220 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 885275013221 tetramer interface [polypeptide binding]; other site 885275013222 active site 885275013223 Mg2+/Mn2+ binding site [ion binding]; other site 885275013224 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 885275013225 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 885275013226 transcriptional repressor IclR; Provisional; Region: PRK11569 885275013227 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 885275013228 Bacterial transcriptional regulator; Region: IclR; pfam01614 885275013229 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 885275013230 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 885275013231 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 885275013232 substrate binding pocket [chemical binding]; other site 885275013233 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 885275013234 B12 binding site [chemical binding]; other site 885275013235 cobalt ligand [ion binding]; other site 885275013236 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 885275013237 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 885275013238 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 885275013239 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 885275013240 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 885275013241 active site pocket [active] 885275013242 oxyanion hole [active] 885275013243 catalytic triad [active] 885275013244 active site nucleophile [active] 885275013245 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 885275013246 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 885275013247 putative NAD(P) binding site [chemical binding]; other site 885275013248 catalytic Zn binding site [ion binding]; other site 885275013249 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 885275013250 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 885275013251 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 885275013252 active site 885275013253 phosphorylation site [posttranslational modification] 885275013254 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 885275013255 active pocket/dimerization site; other site 885275013256 active site 885275013257 phosphorylation site [posttranslational modification] 885275013258 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 885275013259 classical (c) SDRs; Region: SDR_c; cd05233 885275013260 NAD(P) binding site [chemical binding]; other site 885275013261 active site 885275013262 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 885275013263 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 885275013264 putative DNA binding site [nucleotide binding]; other site 885275013265 putative Zn2+ binding site [ion binding]; other site 885275013266 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 885275013267 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 885275013268 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 885275013269 RNA binding surface [nucleotide binding]; other site 885275013270 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 885275013271 probable active site [active] 885275013272 hypothetical protein; Provisional; Region: PRK10515 885275013273 aspartate kinase III; Validated; Region: PRK09084 885275013274 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 885275013275 nucleotide binding site [chemical binding]; other site 885275013276 substrate binding site [chemical binding]; other site 885275013277 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 885275013278 lysine allosteric regulatory site; other site 885275013279 dimer interface [polypeptide binding]; other site 885275013280 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 885275013281 dimer interface [polypeptide binding]; other site 885275013282 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 885275013283 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 885275013284 active site 885275013285 dimer interface [polypeptide binding]; other site 885275013286 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 885275013287 dimer interface [polypeptide binding]; other site 885275013288 active site 885275013289 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 885275013290 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 885275013291 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 885275013292 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 885275013293 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 885275013294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275013295 dimer interface [polypeptide binding]; other site 885275013296 conserved gate region; other site 885275013297 putative PBP binding loops; other site 885275013298 ABC-ATPase subunit interface; other site 885275013299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275013300 dimer interface [polypeptide binding]; other site 885275013301 conserved gate region; other site 885275013302 putative PBP binding loops; other site 885275013303 ABC-ATPase subunit interface; other site 885275013304 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 885275013305 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 885275013306 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 885275013307 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 885275013308 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 885275013309 Walker A/P-loop; other site 885275013310 ATP binding site [chemical binding]; other site 885275013311 Q-loop/lid; other site 885275013312 ABC transporter signature motif; other site 885275013313 Walker B; other site 885275013314 D-loop; other site 885275013315 H-loop/switch region; other site 885275013316 TOBE domain; Region: TOBE_2; pfam08402 885275013317 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 885275013318 trimer interface; other site 885275013319 sugar binding site [chemical binding]; other site 885275013320 maltose regulon periplasmic protein; Provisional; Region: PRK10564 885275013321 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 885275013322 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 885275013323 UbiA prenyltransferase family; Region: UbiA; pfam01040 885275013324 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 885275013325 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 885275013326 putative acyl-acceptor binding pocket; other site 885275013327 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 885275013328 LexA repressor; Validated; Region: PRK00215 885275013329 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 885275013330 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 885275013331 Catalytic site [active] 885275013332 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 885275013333 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 885275013334 hypothetical protein; Provisional; Region: PRK10428 885275013335 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 885275013336 metal binding site 2 [ion binding]; metal-binding site 885275013337 putative DNA binding helix; other site 885275013338 metal binding site 1 [ion binding]; metal-binding site 885275013339 dimer interface [polypeptide binding]; other site 885275013340 structural Zn2+ binding site [ion binding]; other site 885275013341 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 885275013342 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 885275013343 FMN binding site [chemical binding]; other site 885275013344 active site 885275013345 catalytic residues [active] 885275013346 substrate binding site [chemical binding]; other site 885275013347 phage shock protein G; Reviewed; Region: pspG; PRK09459 885275013348 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 885275013349 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 885275013350 NADP binding site [chemical binding]; other site 885275013351 dimer interface [polypeptide binding]; other site 885275013352 L-aspartate oxidase; Provisional; Region: PRK06175 885275013353 FAD binding domain; Region: FAD_binding_2; pfam00890 885275013354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275013355 metabolite-proton symporter; Region: 2A0106; TIGR00883 885275013356 putative substrate translocation pore; other site 885275013357 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 885275013358 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 885275013359 substrate binding site [chemical binding]; other site 885275013360 oxyanion hole (OAH) forming residues; other site 885275013361 trimer interface [polypeptide binding]; other site 885275013362 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 885275013363 Coenzyme A transferase; Region: CoA_trans; smart00882 885275013364 Coenzyme A transferase; Region: CoA_trans; cl17247 885275013365 Transcriptional regulators [Transcription]; Region: PurR; COG1609 885275013366 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 885275013367 DNA binding site [nucleotide binding] 885275013368 domain linker motif; other site 885275013369 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 885275013370 putative dimerization interface [polypeptide binding]; other site 885275013371 putative ligand binding site [chemical binding]; other site 885275013372 replicative DNA helicase; Provisional; Region: PRK08006 885275013373 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 885275013374 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 885275013375 Walker A motif; other site 885275013376 ATP binding site [chemical binding]; other site 885275013377 Walker B motif; other site 885275013378 DNA binding loops [nucleotide binding] 885275013379 putative lipoprotein; Provisional; Region: PRK10533 885275013380 alanine racemase; Reviewed; Region: alr; PRK00053 885275013381 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 885275013382 active site 885275013383 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 885275013384 substrate binding site [chemical binding]; other site 885275013385 catalytic residues [active] 885275013386 dimer interface [polypeptide binding]; other site 885275013387 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 885275013388 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 885275013389 active site 885275013390 (T/H)XGH motif; other site 885275013391 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 885275013392 AAA domain; Region: AAA_28; pfam13521 885275013393 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 885275013394 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 885275013395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275013396 homodimer interface [polypeptide binding]; other site 885275013397 catalytic residue [active] 885275013398 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 885275013399 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 885275013400 TPP-binding site [chemical binding]; other site 885275013401 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 885275013402 dimer interface [polypeptide binding]; other site 885275013403 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 885275013404 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 885275013405 E3 interaction surface; other site 885275013406 lipoyl attachment site [posttranslational modification]; other site 885275013407 e3 binding domain; Region: E3_binding; pfam02817 885275013408 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 885275013409 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 885275013410 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 885275013411 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 885275013412 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 885275013413 CoA-ligase; Region: Ligase_CoA; pfam00549 885275013414 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 885275013415 CoA binding domain; Region: CoA_binding; smart00881 885275013416 CoA-ligase; Region: Ligase_CoA; pfam00549 885275013417 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 885275013418 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 885275013419 transmembrane helices; other site 885275013420 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 885275013421 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 885275013422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275013423 active site 885275013424 phosphorylation site [posttranslational modification] 885275013425 intermolecular recognition site; other site 885275013426 dimerization interface [polypeptide binding]; other site 885275013427 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275013428 Walker A motif; other site 885275013429 ATP binding site [chemical binding]; other site 885275013430 Walker B motif; other site 885275013431 arginine finger; other site 885275013432 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 885275013433 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 885275013434 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885275013435 dimer interface [polypeptide binding]; other site 885275013436 phosphorylation site [posttranslational modification] 885275013437 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275013438 ATP binding site [chemical binding]; other site 885275013439 Mg2+ binding site [ion binding]; other site 885275013440 G-X-G motif; other site 885275013441 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885275013442 active site 885275013443 motif I; other site 885275013444 motif II; other site 885275013445 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 885275013446 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 885275013447 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 885275013448 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 885275013449 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 885275013450 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 885275013451 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 885275013452 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 885275013453 dimer interface [polypeptide binding]; other site 885275013454 ssDNA binding site [nucleotide binding]; other site 885275013455 tetramer (dimer of dimers) interface [polypeptide binding]; other site 885275013456 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 885275013457 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 885275013458 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 885275013459 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885275013460 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 885275013461 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275013462 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 885275013463 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 885275013464 DNA binding residues [nucleotide binding] 885275013465 dimer interface [polypeptide binding]; other site 885275013466 [2Fe-2S] cluster binding site [ion binding]; other site 885275013467 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 885275013468 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 885275013469 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 885275013470 Transcriptional regulator [Transcription]; Region: LysR; COG0583 885275013471 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275013472 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 885275013473 putative dimerization interface [polypeptide binding]; other site 885275013474 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 885275013475 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 885275013476 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 885275013477 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 885275013478 Na binding site [ion binding]; other site 885275013479 Predicted membrane protein [Function unknown]; Region: COG3162 885275013480 acetyl-CoA synthetase; Provisional; Region: PRK00174 885275013481 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 885275013482 active site 885275013483 CoA binding site [chemical binding]; other site 885275013484 acyl-activating enzyme (AAE) consensus motif; other site 885275013485 AMP binding site [chemical binding]; other site 885275013486 acetate binding site [chemical binding]; other site 885275013487 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 885275013488 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 885275013489 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 885275013490 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 885275013491 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 885275013492 heme lyase subunit NrfE; Provisional; Region: PRK10369 885275013493 Cytochrome C biogenesis protein; Region: CcmH; cl01179 885275013494 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 885275013495 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 885275013496 binding surface 885275013497 TPR motif; other site 885275013498 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 885275013499 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 885275013500 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 885275013501 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 885275013502 Sel1-like repeats; Region: SEL1; smart00671 885275013503 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 885275013504 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 885275013505 Walker A/P-loop; other site 885275013506 ATP binding site [chemical binding]; other site 885275013507 Q-loop/lid; other site 885275013508 ABC transporter signature motif; other site 885275013509 Walker B; other site 885275013510 D-loop; other site 885275013511 H-loop/switch region; other site 885275013512 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 885275013513 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 885275013514 Walker A/P-loop; other site 885275013515 ATP binding site [chemical binding]; other site 885275013516 Q-loop/lid; other site 885275013517 ABC transporter signature motif; other site 885275013518 Walker B; other site 885275013519 D-loop; other site 885275013520 H-loop/switch region; other site 885275013521 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 885275013522 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 885275013523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275013524 dimer interface [polypeptide binding]; other site 885275013525 conserved gate region; other site 885275013526 ABC-ATPase subunit interface; other site 885275013527 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 885275013528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275013529 dimer interface [polypeptide binding]; other site 885275013530 conserved gate region; other site 885275013531 putative PBP binding loops; other site 885275013532 ABC-ATPase subunit interface; other site 885275013533 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 885275013534 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 885275013535 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 885275013536 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 885275013537 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 885275013538 multidrug resistance protein MdtN; Provisional; Region: PRK10476 885275013539 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885275013540 HlyD family secretion protein; Region: HlyD_3; pfam13437 885275013541 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 885275013542 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 885275013543 D-allose kinase; Provisional; Region: PRK09698 885275013544 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 885275013545 nucleotide binding site [chemical binding]; other site 885275013546 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 885275013547 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 885275013548 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 885275013549 substrate binding site [chemical binding]; other site 885275013550 hexamer interface [polypeptide binding]; other site 885275013551 metal binding site [ion binding]; metal-binding site 885275013552 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 885275013553 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 885275013554 TM-ABC transporter signature motif; other site 885275013555 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 885275013556 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885275013557 Walker A/P-loop; other site 885275013558 ATP binding site [chemical binding]; other site 885275013559 Q-loop/lid; other site 885275013560 ABC transporter signature motif; other site 885275013561 Walker B; other site 885275013562 D-loop; other site 885275013563 H-loop/switch region; other site 885275013564 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 885275013565 D-allose transporter subunit; Provisional; Region: PRK09701 885275013566 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 885275013567 ligand binding site [chemical binding]; other site 885275013568 dimerization interface [polypeptide binding]; other site 885275013569 zinc binding site [ion binding]; other site 885275013570 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 885275013571 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 885275013572 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 885275013573 putative active site [active] 885275013574 ribose 5-phosphate isomerase B; Region: rpiB; TIGR01120 885275013575 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 885275013576 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 885275013577 Coenzyme A binding pocket [chemical binding]; other site 885275013578 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 885275013579 AAA domain; Region: AAA_18; pfam13238 885275013580 active site 885275013581 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 885275013582 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 885275013583 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 885275013584 active site 885275013585 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 885275013586 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 885275013587 Walker A/P-loop; other site 885275013588 ATP binding site [chemical binding]; other site 885275013589 Q-loop/lid; other site 885275013590 ABC transporter signature motif; other site 885275013591 Walker B; other site 885275013592 D-loop; other site 885275013593 H-loop/switch region; other site 885275013594 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 885275013595 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 885275013596 Walker A/P-loop; other site 885275013597 ATP binding site [chemical binding]; other site 885275013598 Q-loop/lid; other site 885275013599 ABC transporter signature motif; other site 885275013600 Walker B; other site 885275013601 D-loop; other site 885275013602 H-loop/switch region; other site 885275013603 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 885275013604 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 885275013605 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 885275013606 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 885275013607 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 885275013608 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 885275013609 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885275013610 DNA-binding site [nucleotide binding]; DNA binding site 885275013611 UTRA domain; Region: UTRA; pfam07702 885275013612 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 885275013613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885275013614 dimer interface [polypeptide binding]; other site 885275013615 conserved gate region; other site 885275013616 putative PBP binding loops; other site 885275013617 ABC-ATPase subunit interface; other site 885275013618 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 885275013619 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 885275013620 substrate binding pocket [chemical binding]; other site 885275013621 membrane-bound complex binding site; other site 885275013622 hinge residues; other site 885275013623 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 885275013624 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 885275013625 Walker A/P-loop; other site 885275013626 ATP binding site [chemical binding]; other site 885275013627 Q-loop/lid; other site 885275013628 ABC transporter signature motif; other site 885275013629 Walker B; other site 885275013630 D-loop; other site 885275013631 H-loop/switch region; other site 885275013632 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 885275013633 dimer interface [polypeptide binding]; other site 885275013634 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 885275013635 hypothetical protein; Provisional; Region: PRK10220 885275013636 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 885275013637 PhnA protein; Region: PhnA; pfam03831 885275013638 hypothetical protein; Provisional; Region: PRK09866 885275013639 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 885275013640 G1 box; other site 885275013641 GTP/Mg2+ binding site [chemical binding]; other site 885275013642 G2 box; other site 885275013643 Switch I region; other site 885275013644 G3 box; other site 885275013645 Switch II region; other site 885275013646 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 885275013647 G2 box; other site 885275013648 Switch I region; other site 885275013649 G3 box; other site 885275013650 Switch II region; other site 885275013651 G4 box; other site 885275013652 G5 box; other site 885275013653 YjcZ-like protein; Region: YjcZ; pfam13990 885275013654 proline/glycine betaine transporter; Provisional; Region: PRK10642 885275013655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275013656 putative substrate translocation pore; other site 885275013657 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 885275013658 sensor protein BasS/PmrB; Provisional; Region: PRK10755 885275013659 HAMP domain; Region: HAMP; pfam00672 885275013660 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885275013661 dimer interface [polypeptide binding]; other site 885275013662 phosphorylation site [posttranslational modification] 885275013663 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275013664 ATP binding site [chemical binding]; other site 885275013665 Mg2+ binding site [ion binding]; other site 885275013666 G-X-G motif; other site 885275013667 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 885275013668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275013669 active site 885275013670 phosphorylation site [posttranslational modification] 885275013671 intermolecular recognition site; other site 885275013672 dimerization interface [polypeptide binding]; other site 885275013673 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 885275013674 DNA binding site [nucleotide binding] 885275013675 putative metal dependent hydrolase; Provisional; Region: PRK11598 885275013676 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 885275013677 Sulfatase; Region: Sulfatase; pfam00884 885275013678 arginine:agmatin antiporter; Provisional; Region: PRK10644 885275013679 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 885275013680 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275013681 arginine decarboxylase; Provisional; Region: PRK15029 885275013682 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 885275013683 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 885275013684 homodimer interface [polypeptide binding]; other site 885275013685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275013686 catalytic residue [active] 885275013687 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 885275013688 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 885275013689 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275013690 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275013691 alpha-galactosidase; Provisional; Region: PRK15076 885275013692 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 885275013693 NAD binding site [chemical binding]; other site 885275013694 sugar binding site [chemical binding]; other site 885275013695 divalent metal binding site [ion binding]; other site 885275013696 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 885275013697 dimer interface [polypeptide binding]; other site 885275013698 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 885275013699 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 885275013700 fumarate hydratase; Provisional; Region: PRK15389 885275013701 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 885275013702 Fumarase C-terminus; Region: Fumerase_C; pfam05683 885275013703 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 885275013704 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 885275013705 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 885275013706 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275013707 active site 885275013708 phosphorylation site [posttranslational modification] 885275013709 intermolecular recognition site; other site 885275013710 dimerization interface [polypeptide binding]; other site 885275013711 Transcriptional regulator; Region: CitT; pfam12431 885275013712 sensory histidine kinase DcuS; Provisional; Region: PRK11086 885275013713 PAS domain; Region: PAS; smart00091 885275013714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275013715 ATP binding site [chemical binding]; other site 885275013716 Mg2+ binding site [ion binding]; other site 885275013717 G-X-G motif; other site 885275013718 Uncharacterized conserved protein [Function unknown]; Region: COG3592 885275013719 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 885275013720 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 885275013721 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 885275013722 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 885275013723 dimer interface [polypeptide binding]; other site 885275013724 putative anticodon binding site; other site 885275013725 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 885275013726 motif 1; other site 885275013727 active site 885275013728 motif 2; other site 885275013729 motif 3; other site 885275013730 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 885275013731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275013732 putative substrate translocation pore; other site 885275013733 POT family; Region: PTR2; pfam00854 885275013734 lysine decarboxylase CadA; Provisional; Region: PRK15400 885275013735 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 885275013736 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 885275013737 homodimer interface [polypeptide binding]; other site 885275013738 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885275013739 catalytic residue [active] 885275013740 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 885275013741 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 885275013742 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 885275013743 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 885275013744 DNA binding site [nucleotide binding] 885275013745 putative transcriptional regulator; Provisional; Region: PRK11640 885275013746 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 885275013747 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 885275013748 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 885275013749 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 885275013750 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 885275013751 DsbD alpha interface [polypeptide binding]; other site 885275013752 catalytic residues [active] 885275013753 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 885275013754 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 885275013755 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 885275013756 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 885275013757 Aspartase; Region: Aspartase; cd01357 885275013758 active sites [active] 885275013759 tetramer interface [polypeptide binding]; other site 885275013760 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 885275013761 putative transporter; Provisional; Region: PRK11021 885275013762 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 885275013763 oligomerisation interface [polypeptide binding]; other site 885275013764 mobile loop; other site 885275013765 roof hairpin; other site 885275013766 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 885275013767 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 885275013768 ring oligomerisation interface [polypeptide binding]; other site 885275013769 ATP/Mg binding site [chemical binding]; other site 885275013770 stacking interactions; other site 885275013771 hinge regions; other site 885275013772 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 885275013773 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 885275013774 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885275013775 FeS/SAM binding site; other site 885275013776 elongation factor P; Validated; Region: PRK00529 885275013777 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 885275013778 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 885275013779 RNA binding site [nucleotide binding]; other site 885275013780 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 885275013781 RNA binding site [nucleotide binding]; other site 885275013782 entericidin A; Provisional; Region: PRK09810 885275013783 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 885275013784 multidrug efflux system protein; Provisional; Region: PRK11431 885275013785 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 885275013786 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 885275013787 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 885275013788 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 885275013789 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 885275013790 Iron-sulfur protein interface; other site 885275013791 proximal quinone binding site [chemical binding]; other site 885275013792 C-subunit interface; other site 885275013793 distal quinone binding site; other site 885275013794 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 885275013795 D-subunit interface [polypeptide binding]; other site 885275013796 Iron-sulfur protein interface; other site 885275013797 proximal quinone binding site [chemical binding]; other site 885275013798 distal quinone binding site [chemical binding]; other site 885275013799 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 885275013800 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 885275013801 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 885275013802 L-aspartate oxidase; Provisional; Region: PRK06175 885275013803 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 885275013804 poxB regulator PoxA; Provisional; Region: PRK09350 885275013805 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 885275013806 motif 1; other site 885275013807 dimer interface [polypeptide binding]; other site 885275013808 active site 885275013809 motif 2; other site 885275013810 motif 3; other site 885275013811 inner membrane transporter YjeM; Provisional; Region: PRK15238 885275013812 putative mechanosensitive channel protein; Provisional; Region: PRK10929 885275013813 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 885275013814 DNA-binding site [nucleotide binding]; DNA binding site 885275013815 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 885275013816 Mechanosensitive ion channel; Region: MS_channel; pfam00924 885275013817 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 885275013818 GTPase RsgA; Reviewed; Region: PRK12288 885275013819 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 885275013820 RNA binding site [nucleotide binding]; other site 885275013821 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 885275013822 GTPase/Zn-binding domain interface [polypeptide binding]; other site 885275013823 GTP/Mg2+ binding site [chemical binding]; other site 885275013824 G4 box; other site 885275013825 G5 box; other site 885275013826 G1 box; other site 885275013827 Switch I region; other site 885275013828 G2 box; other site 885275013829 G3 box; other site 885275013830 Switch II region; other site 885275013831 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 885275013832 catalytic site [active] 885275013833 putative active site [active] 885275013834 putative substrate binding site [chemical binding]; other site 885275013835 dimer interface [polypeptide binding]; other site 885275013836 epoxyqueuosine reductase; Region: TIGR00276 885275013837 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 885275013838 putative carbohydrate kinase; Provisional; Region: PRK10565 885275013839 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 885275013840 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 885275013841 putative substrate binding site [chemical binding]; other site 885275013842 putative ATP binding site [chemical binding]; other site 885275013843 ADP-binding protein; Provisional; Region: PRK10646 885275013844 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 885275013845 AMIN domain; Region: AMIN; pfam11741 885275013846 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 885275013847 active site 885275013848 metal binding site [ion binding]; metal-binding site 885275013849 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 885275013850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275013851 ATP binding site [chemical binding]; other site 885275013852 Mg2+ binding site [ion binding]; other site 885275013853 G-X-G motif; other site 885275013854 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 885275013855 ATP binding site [chemical binding]; other site 885275013856 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 885275013857 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 885275013858 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 885275013859 bacterial Hfq-like; Region: Hfq; cd01716 885275013860 hexamer interface [polypeptide binding]; other site 885275013861 Sm1 motif; other site 885275013862 RNA binding site [nucleotide binding]; other site 885275013863 Sm2 motif; other site 885275013864 GTPase HflX; Provisional; Region: PRK11058 885275013865 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 885275013866 HflX GTPase family; Region: HflX; cd01878 885275013867 G1 box; other site 885275013868 GTP/Mg2+ binding site [chemical binding]; other site 885275013869 Switch I region; other site 885275013870 G2 box; other site 885275013871 G3 box; other site 885275013872 Switch II region; other site 885275013873 G4 box; other site 885275013874 G5 box; other site 885275013875 FtsH protease regulator HflK; Provisional; Region: PRK10930 885275013876 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 885275013877 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 885275013878 FtsH protease regulator HflC; Provisional; Region: PRK11029 885275013879 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 885275013880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 885275013881 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 885275013882 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 885275013883 GDP-binding site [chemical binding]; other site 885275013884 ACT binding site; other site 885275013885 IMP binding site; other site 885275013886 Predicted transcriptional regulator [Transcription]; Region: COG1959 885275013887 transcriptional repressor NsrR; Provisional; Region: PRK11014 885275013888 exoribonuclease R; Provisional; Region: PRK11642 885275013889 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 885275013890 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 885275013891 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 885275013892 RNB domain; Region: RNB; pfam00773 885275013893 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 885275013894 RNA binding site [nucleotide binding]; other site 885275013895 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 885275013896 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 885275013897 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 885275013898 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 885275013899 PspA/IM30 family; Region: PspA_IM30; pfam04012 885275013900 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 885275013901 Predicted membrane protein [Function unknown]; Region: COG3766 885275013902 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 885275013903 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 885275013904 Predicted integral membrane protein [Function unknown]; Region: COG5463 885275013905 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 885275013906 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 885275013907 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 885275013908 FAD binding site [chemical binding]; other site 885275013909 substrate binding site [chemical binding]; other site 885275013910 catalytic residues [active] 885275013911 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 885275013912 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 885275013913 esterase; Provisional; Region: PRK10566 885275013914 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 885275013915 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 885275013916 transcriptional repressor UlaR; Provisional; Region: PRK13509 885275013917 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 885275013918 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 885275013919 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 885275013920 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 885275013921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 885275013922 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 885275013923 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 885275013924 active site 885275013925 P-loop; other site 885275013926 phosphorylation site [posttranslational modification] 885275013927 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 885275013928 active site 885275013929 phosphorylation site [posttranslational modification] 885275013930 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 885275013931 active site 885275013932 dimer interface [polypeptide binding]; other site 885275013933 magnesium binding site [ion binding]; other site 885275013934 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 885275013935 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 885275013936 AP (apurinic/apyrimidinic) site pocket; other site 885275013937 DNA interaction; other site 885275013938 Metal-binding active site; metal-binding site 885275013939 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 885275013940 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 885275013941 intersubunit interface [polypeptide binding]; other site 885275013942 active site 885275013943 Zn2+ binding site [ion binding]; other site 885275013944 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 885275013945 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 885275013946 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 885275013947 dimer interface [polypeptide binding]; other site 885275013948 ssDNA binding site [nucleotide binding]; other site 885275013949 tetramer (dimer of dimers) interface [polypeptide binding]; other site 885275013950 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 885275013951 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 885275013952 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 885275013953 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 885275013954 Helix-turn-helix domain; Region: HTH_31; pfam13560 885275013955 sequence-specific DNA binding site [nucleotide binding]; other site 885275013956 salt bridge; other site 885275013957 HipA-like N-terminal domain; Region: HipA_N; pfam07805 885275013958 HipA-like C-terminal domain; Region: HipA_C; pfam07804 885275013959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885275013960 D-galactonate transporter; Region: 2A0114; TIGR00893 885275013961 putative substrate translocation pore; other site 885275013962 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 885275013963 L-aspartate oxidase; Provisional; Region: PRK06175 885275013964 L-aspartate oxidase; Provisional; Region: PRK06175 885275013965 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 885275013966 Coenzyme A transferase; Region: CoA_trans; smart00882 885275013967 Coenzyme A transferase; Region: CoA_trans; cl17247 885275013968 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 885275013969 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 885275013970 substrate binding site [chemical binding]; other site 885275013971 oxyanion hole (OAH) forming residues; other site 885275013972 trimer interface [polypeptide binding]; other site 885275013973 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 885275013974 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 885275013975 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337 885275013976 putative NAD(P) binding site [chemical binding]; other site 885275013977 active site 885275013978 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 885275013979 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 885275013980 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 885275013981 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 885275013982 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 885275013983 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 885275013984 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 885275013985 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 885275013986 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 885275013987 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 885275013988 Hemerythrin-like domain; Region: Hr-like; cd12108 885275013989 Fe binding site [ion binding]; other site 885275013990 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 885275013991 EamA-like transporter family; Region: EamA; pfam00892 885275013992 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 885275013993 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 885275013994 NADP binding site [chemical binding]; other site 885275013995 Predicted transcriptional regulators [Transcription]; Region: COG1733 885275013996 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 885275013997 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 885275013998 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 885275013999 active site 885275014000 metal binding site [ion binding]; metal-binding site 885275014001 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 885275014002 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 885275014003 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 885275014004 active site 885275014005 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 885275014006 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 885275014007 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 885275014008 Domain of unknown function DUF21; Region: DUF21; pfam01595 885275014009 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 885275014010 Transporter associated domain; Region: CorC_HlyC; smart01091 885275014011 methionine sulfoxide reductase A; Provisional; Region: PRK00058 885275014012 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 885275014013 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 885275014014 Surface antigen; Region: Bac_surface_Ag; pfam01103 885275014015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 885275014016 Family of unknown function (DUF490); Region: DUF490; pfam04357 885275014017 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 885275014018 putative active site pocket [active] 885275014019 dimerization interface [polypeptide binding]; other site 885275014020 putative catalytic residue [active] 885275014021 Sel1-like repeats; Region: SEL1; smart00671 885275014022 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 885275014023 Sel1-like repeats; Region: SEL1; smart00671 885275014024 Sel1-like repeats; Region: SEL1; smart00671 885275014025 Sel1-like repeats; Region: SEL1; smart00671 885275014026 Sel1-like repeats; Region: SEL1; smart00671 885275014027 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 885275014028 Sel1-like repeats; Region: SEL1; smart00671 885275014029 Sel1-like repeats; Region: SEL1; smart00671 885275014030 Sel1-like repeats; Region: SEL1; smart00671 885275014031 Sel1-like repeats; Region: SEL1; smart00671 885275014032 Sel1-like repeats; Region: SEL1; smart00671 885275014033 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 885275014034 dimer interface [polypeptide binding]; other site 885275014035 substrate binding site [chemical binding]; other site 885275014036 metal binding sites [ion binding]; metal-binding site 885275014037 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 885275014038 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 885275014039 putative ligand binding site [chemical binding]; other site 885275014040 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 885275014041 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 885275014042 Walker A/P-loop; other site 885275014043 ATP binding site [chemical binding]; other site 885275014044 Q-loop/lid; other site 885275014045 ABC transporter signature motif; other site 885275014046 Walker B; other site 885275014047 D-loop; other site 885275014048 H-loop/switch region; other site 885275014049 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 885275014050 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 885275014051 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 885275014052 TM-ABC transporter signature motif; other site 885275014053 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 885275014054 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 885275014055 TM-ABC transporter signature motif; other site 885275014056 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 885275014057 AMP binding site [chemical binding]; other site 885275014058 metal binding site [ion binding]; metal-binding site 885275014059 active site 885275014060 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 885275014061 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 885275014062 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 885275014063 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 885275014064 hypothetical protein; Provisional; Region: PRK05255 885275014065 peptidase PmbA; Provisional; Region: PRK11040 885275014066 cytochrome b562; Provisional; Region: PRK15058 885275014067 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 885275014068 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885275014069 FeS/SAM binding site; other site 885275014070 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 885275014071 ATP cone domain; Region: ATP-cone; pfam03477 885275014072 Class III ribonucleotide reductase; Region: RNR_III; cd01675 885275014073 effector binding site; other site 885275014074 active site 885275014075 Zn binding site [ion binding]; other site 885275014076 glycine loop; other site 885275014077 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 885275014078 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 885275014079 Ca binding site [ion binding]; other site 885275014080 active site 885275014081 catalytic site [active] 885275014082 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 885275014083 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 885275014084 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 885275014085 active site turn [active] 885275014086 phosphorylation site [posttranslational modification] 885275014087 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 885275014088 trehalose repressor; Provisional; Region: treR; PRK09492 885275014089 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 885275014090 DNA binding site [nucleotide binding] 885275014091 domain linker motif; other site 885275014092 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 885275014093 dimerization interface [polypeptide binding]; other site 885275014094 ligand binding site [chemical binding]; other site 885275014095 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 885275014096 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 885275014097 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 885275014098 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 885275014099 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885275014100 motif II; other site 885275014101 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 885275014102 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 885275014103 homotrimer interaction site [polypeptide binding]; other site 885275014104 putative active site [active] 885275014105 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 885275014106 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 885275014107 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 885275014108 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 885275014109 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 885275014110 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 885275014111 PyrBI operon leader peptide; Region: PyrBI_leader; pfam08052 885275014112 Arginine repressor [Transcription]; Region: ArgR; COG1438 885275014113 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 885275014114 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 885275014115 Predicted membrane protein [Function unknown]; Region: COG1288 885275014116 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 885275014117 ornithine carbamoyltransferase; Validated; Region: PRK02102 885275014118 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 885275014119 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 885275014120 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 885275014121 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 885275014122 putative substrate binding site [chemical binding]; other site 885275014123 nucleotide binding site [chemical binding]; other site 885275014124 nucleotide binding site [chemical binding]; other site 885275014125 homodimer interface [polypeptide binding]; other site 885275014126 arginine deiminase; Provisional; Region: PRK01388 885275014127 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 885275014128 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 885275014129 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 885275014130 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 885275014131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 885275014132 RNase E inhibitor protein; Provisional; Region: PRK11191 885275014133 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 885275014134 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 885275014135 Coenzyme A binding pocket [chemical binding]; other site 885275014136 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 885275014137 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 885275014138 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 885275014139 HIGH motif; other site 885275014140 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 885275014141 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 885275014142 active site 885275014143 KMSKS motif; other site 885275014144 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 885275014145 tRNA binding surface [nucleotide binding]; other site 885275014146 anticodon binding site; other site 885275014147 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 885275014148 DNA polymerase III subunit chi; Validated; Region: PRK05728 885275014149 multifunctional aminopeptidase A; Provisional; Region: PRK00913 885275014150 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 885275014151 interface (dimer of trimers) [polypeptide binding]; other site 885275014152 Substrate-binding/catalytic site; other site 885275014153 Zn-binding sites [ion binding]; other site 885275014154 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 885275014155 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 885275014156 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 885275014157 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 885275014158 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 885275014159 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 885275014160 Walker A motif; other site 885275014161 ATP binding site [chemical binding]; other site 885275014162 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 885275014163 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 885275014164 DNA binding site [nucleotide binding] 885275014165 domain linker motif; other site 885275014166 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 885275014167 putative dimerization interface [polypeptide binding]; other site 885275014168 putative ligand binding site [chemical binding]; other site 885275014169 fructuronate transporter; Provisional; Region: PRK10034; cl15264 885275014170 gluconate transporter; Region: gntP; TIGR00791 885275014171 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 885275014172 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 885275014173 NADP binding site [chemical binding]; other site 885275014174 homodimer interface [polypeptide binding]; other site 885275014175 active site 885275014176 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 885275014177 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 885275014178 putative NAD(P) binding site [chemical binding]; other site 885275014179 catalytic Zn binding site [ion binding]; other site 885275014180 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 885275014181 ATP-binding site [chemical binding]; other site 885275014182 Gluconate-6-phosphate binding site [chemical binding]; other site 885275014183 Shikimate kinase; Region: SKI; pfam01202 885275014184 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 885275014185 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 885275014186 putative NAD(P) binding site [chemical binding]; other site 885275014187 putative substrate binding site [chemical binding]; other site 885275014188 catalytic Zn binding site [ion binding]; other site 885275014189 structural Zn binding site [ion binding]; other site 885275014190 dimer interface [polypeptide binding]; other site 885275014191 integrase; Provisional; Region: PRK09692 885275014192 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 885275014193 active site 885275014194 Int/Topo IB signature motif; other site 885275014195 HNH endonuclease; Region: HNH_2; pfam13391 885275014196 Protein of unknown function DUF91; Region: DUF91; cl00709 885275014197 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 885275014198 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 885275014199 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 885275014200 Methyltransferase domain; Region: Methyltransf_26; pfam13659 885275014201 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 885275014202 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 885275014203 TIGR02687 family protein; Region: TIGR02687 885275014204 PglZ domain; Region: PglZ; pfam08665 885275014205 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 885275014206 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 885275014207 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 885275014208 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 885275014209 Transposase; Region: HTH_Tnp_1; cl17663 885275014210 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 885275014211 putative transposase OrfB; Reviewed; Region: PHA02517 885275014212 HTH-like domain; Region: HTH_21; pfam13276 885275014213 Integrase core domain; Region: rve; pfam00665 885275014214 Integrase core domain; Region: rve_3; pfam13683 885275014215 Predicted GTPase [General function prediction only]; Region: COG3596 885275014216 YfjP GTPase; Region: YfjP; cd11383 885275014217 Switch I region; other site 885275014218 G2 box; other site 885275014219 Switch II region; other site 885275014220 G3 box; other site 885275014221 G4 box; other site 885275014222 G5 box; other site 885275014223 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 885275014224 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 885275014225 hypothetical protein; Provisional; Region: PRK09945 885275014226 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 885275014227 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 885275014228 Autotransporter beta-domain; Region: Autotransporter; smart00869 885275014229 hypothetical protein; Provisional; Region: PRK09866 885275014230 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 885275014231 G1 box; other site 885275014232 GTP/Mg2+ binding site [chemical binding]; other site 885275014233 G2 box; other site 885275014234 Switch I region; other site 885275014235 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 885275014236 G3 box; other site 885275014237 Switch II region; other site 885275014238 GTP/Mg2+ binding site [chemical binding]; other site 885275014239 G4 box; other site 885275014240 G5 box; other site 885275014241 YjcZ-like protein; Region: YjcZ; pfam13990 885275014242 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 885275014243 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 885275014244 nucleophile elbow; other site 885275014245 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 885275014246 Domain of unknown function (DUF932); Region: DUF932; pfam06067 885275014247 Antirestriction protein; Region: Antirestrict; pfam03230 885275014248 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 885275014249 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 885275014250 MPN+ (JAMM) motif; other site 885275014251 Zinc-binding site [ion binding]; other site 885275014252 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 885275014253 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 885275014254 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 885275014255 active site 885275014256 Int/Topo IB signature motif; other site 885275014257 Restriction endonuclease [Defense mechanisms]; Region: COG3587 885275014258 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 885275014259 ATP binding site [chemical binding]; other site 885275014260 putative Mg++ binding site [ion binding]; other site 885275014261 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 885275014262 DNA methylase; Region: N6_N4_Mtase; cl17433 885275014263 DNA methylase; Region: N6_N4_Mtase; pfam01555 885275014264 DNA methylase; Region: N6_N4_Mtase; cl17433 885275014265 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 885275014266 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311 885275014267 putative active site [active] 885275014268 catalytic site [active] 885275014269 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 885275014270 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 885275014271 ATP binding site [chemical binding]; other site 885275014272 putative Mg++ binding site [ion binding]; other site 885275014273 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 885275014274 nucleotide binding region [chemical binding]; other site 885275014275 ATP-binding site [chemical binding]; other site 885275014276 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 885275014277 WYL domain; Region: WYL; pfam13280 885275014278 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 885275014279 Protein of unknown function DUF91; Region: DUF91; cl00709 885275014280 Homeodomain-like domain; Region: HTH_23; pfam13384 885275014281 Winged helix-turn helix; Region: HTH_29; pfam13551 885275014282 Domain of unknown function (DUF303); Region: DUF303; pfam03629 885275014283 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 885275014284 Kelch motif; Region: Kelch_1; pfam01344 885275014285 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 885275014286 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 885275014287 Int/Topo IB signature motif; other site 885275014288 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 885275014289 Int/Topo IB signature motif; other site 885275014290 Fimbrial protein; Region: Fimbrial; cl01416 885275014291 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 885275014292 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 885275014293 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 885275014294 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 885275014295 outer membrane usher protein; Provisional; Region: PRK15193 885275014296 PapC N-terminal domain; Region: PapC_N; pfam13954 885275014297 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 885275014298 PapC C-terminal domain; Region: PapC_C; pfam13953 885275014299 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 885275014300 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 885275014301 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 885275014302 mannosyl binding site [chemical binding]; other site 885275014303 Fimbrial protein; Region: Fimbrial; pfam00419 885275014304 fructuronate transporter; Provisional; Region: PRK10034 885275014305 gluconate transporter; Region: gntP; TIGR00791 885275014306 mannonate dehydratase; Region: uxuA; TIGR00695 885275014307 mannonate dehydratase; Provisional; Region: PRK03906 885275014308 D-mannonate oxidoreductase; Provisional; Region: PRK15037 885275014309 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 885275014310 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 885275014311 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 885275014312 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885275014313 DNA-binding site [nucleotide binding]; DNA binding site 885275014314 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 885275014315 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 885275014316 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 885275014317 cell density-dependent motility repressor; Provisional; Region: PRK10082 885275014318 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885275014319 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 885275014320 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 885275014321 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 885275014322 dimer interface [polypeptide binding]; other site 885275014323 active site 885275014324 hypothetical protein; Provisional; Region: PRK10519 885275014325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 885275014326 Nucleoside recognition; Region: Gate; pfam07670 885275014327 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 885275014328 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 885275014329 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 885275014330 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 885275014331 SdiA-regulated; Region: SdiA-regulated; cd09971 885275014332 putative active site [active] 885275014333 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 885275014334 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 885275014335 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 885275014336 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 885275014337 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 885275014338 Predicted membrane protein [Function unknown]; Region: COG2733 885275014339 putative transposase; Provisional; Region: PRK09857 885275014340 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 885275014341 Uncharacterized conserved protein [Function unknown]; Region: COG1479 885275014342 Protein of unknown function DUF262; Region: DUF262; pfam03235 885275014343 Protein of unknown function DUF262; Region: DUF262; pfam03235 885275014344 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 885275014345 Uncharacterized conserved protein [Function unknown]; Region: COG3586 885275014346 endoribonuclease SymE; Provisional; Region: PRK13605 885275014347 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 885275014348 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 885275014349 HsdM N-terminal domain; Region: HsdM_N; pfam12161 885275014350 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 885275014351 Methyltransferase domain; Region: Methyltransf_26; pfam13659 885275014352 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 885275014353 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 885275014354 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 885275014355 ATP binding site [chemical binding]; other site 885275014356 putative Mg++ binding site [ion binding]; other site 885275014357 Uncharacterized conserved protein [Function unknown]; Region: COG1479 885275014358 Protein of unknown function DUF262; Region: DUF262; pfam03235 885275014359 Protein of unknown function DUF262; Region: DUF262; pfam03235 885275014360 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 885275014361 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 885275014362 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 885275014363 P-loop, Walker A motif; other site 885275014364 Base recognition motif; other site 885275014365 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 885275014366 Uncharacterized small protein [Function unknown]; Region: COG2879 885275014367 carbon starvation protein A; Provisional; Region: PRK15015 885275014368 Carbon starvation protein CstA; Region: CstA; pfam02554 885275014369 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 885275014370 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 885275014371 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 885275014372 dimer interface [polypeptide binding]; other site 885275014373 ligand binding site [chemical binding]; other site 885275014374 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 885275014375 dimerization interface [polypeptide binding]; other site 885275014376 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 885275014377 dimer interface [polypeptide binding]; other site 885275014378 putative CheW interface [polypeptide binding]; other site 885275014379 DctM-like transporters; Region: DctM; pfam06808 885275014380 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 885275014381 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 885275014382 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 885275014383 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 885275014384 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 885275014385 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 885275014386 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885275014387 DNA-binding site [nucleotide binding]; DNA binding site 885275014388 Transcriptional regulators [Transcription]; Region: GntR; COG1802 885275014389 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 885275014390 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 885275014391 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 885275014392 putative NAD(P) binding site [chemical binding]; other site 885275014393 catalytic Zn binding site [ion binding]; other site 885275014394 structural Zn binding site [ion binding]; other site 885275014395 phosphoglycerol transferase I; Provisional; Region: PRK03776 885275014396 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 885275014397 hypothetical protein; Provisional; Region: PRK11667 885275014398 DNA replication protein DnaC; Validated; Region: PRK07952 885275014399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885275014400 Walker A motif; other site 885275014401 ATP binding site [chemical binding]; other site 885275014402 Walker B motif; other site 885275014403 primosomal protein DnaI; Provisional; Region: PRK02854 885275014404 hypothetical protein; Provisional; Region: PRK09917 885275014405 Uncharacterized conserved protein [Function unknown]; Region: COG2966 885275014406 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 885275014407 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 885275014408 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885275014409 DNA binding residues [nucleotide binding] 885275014410 dimerization interface [polypeptide binding]; other site 885275014411 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 885275014412 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885275014413 DNA binding residues [nucleotide binding] 885275014414 dimerization interface [polypeptide binding]; other site 885275014415 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 885275014416 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 885275014417 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 885275014418 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 885275014419 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 885275014420 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 885275014421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885275014422 S-adenosylmethionine binding site [chemical binding]; other site 885275014423 DNA polymerase III subunit psi; Validated; Region: PRK06856 885275014424 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 885275014425 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 885275014426 Coenzyme A binding pocket [chemical binding]; other site 885275014427 dUMP phosphatase; Provisional; Region: PRK09449 885275014428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885275014429 motif II; other site 885275014430 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 885275014431 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 885275014432 G1 box; other site 885275014433 putative GEF interaction site [polypeptide binding]; other site 885275014434 GTP/Mg2+ binding site [chemical binding]; other site 885275014435 Switch I region; other site 885275014436 G2 box; other site 885275014437 G3 box; other site 885275014438 Switch II region; other site 885275014439 G4 box; other site 885275014440 G5 box; other site 885275014441 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 885275014442 periplasmic protein; Provisional; Region: PRK10568 885275014443 BON domain; Region: BON; pfam04972 885275014444 BON domain; Region: BON; pfam04972 885275014445 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 885275014446 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 885275014447 active site 885275014448 nucleophile elbow; other site 885275014449 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 885275014450 active site 885275014451 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 885275014452 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885275014453 FeS/SAM binding site; other site 885275014454 hypothetical protein; Provisional; Region: PRK10977 885275014455 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 885275014456 intersubunit interface [polypeptide binding]; other site 885275014457 active site 885275014458 catalytic residue [active] 885275014459 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 885275014460 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 885275014461 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 885275014462 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 885275014463 phosphopentomutase; Provisional; Region: PRK05362 885275014464 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 885275014465 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 885275014466 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 885275014467 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 885275014468 HipA-like N-terminal domain; Region: HipA_N; pfam07805 885275014469 HipA-like C-terminal domain; Region: HipA_C; pfam07804 885275014470 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 885275014471 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 885275014472 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 885275014473 hypothetical protein; Provisional; Region: PRK11246 885275014474 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 885275014475 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885275014476 motif II; other site 885275014477 DNA repair protein RadA; Region: sms; TIGR00416 885275014478 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 885275014479 Walker A motif/ATP binding site; other site 885275014480 ATP binding site [chemical binding]; other site 885275014481 Walker B motif; other site 885275014482 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 885275014483 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 885275014484 non-specific DNA binding site [nucleotide binding]; other site 885275014485 salt bridge; other site 885275014486 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 885275014487 sequence-specific DNA binding site [nucleotide binding]; other site 885275014488 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 885275014489 active site 885275014490 (T/H)XGH motif; other site 885275014491 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 885275014492 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 885275014493 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 885275014494 non-specific DNA binding site [nucleotide binding]; other site 885275014495 salt bridge; other site 885275014496 sequence-specific DNA binding site [nucleotide binding]; other site 885275014497 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 885275014498 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885275014499 Walker A/P-loop; other site 885275014500 ATP binding site [chemical binding]; other site 885275014501 Q-loop/lid; other site 885275014502 ABC transporter signature motif; other site 885275014503 Walker B; other site 885275014504 D-loop; other site 885275014505 H-loop/switch region; other site 885275014506 ABC transporter; Region: ABC_tran_2; pfam12848 885275014507 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 885275014508 lytic murein transglycosylase; Provisional; Region: PRK11619 885275014509 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 885275014510 N-acetyl-D-glucosamine binding site [chemical binding]; other site 885275014511 catalytic residue [active] 885275014512 Trp operon repressor; Provisional; Region: PRK01381 885275014513 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 885275014514 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 885275014515 catalytic core [active] 885275014516 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 885275014517 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885275014518 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 885275014519 hypothetical protein; Provisional; Region: PRK10756 885275014520 CreA protein; Region: CreA; pfam05981 885275014521 DNA-binding response regulator CreB; Provisional; Region: PRK11083 885275014522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275014523 active site 885275014524 phosphorylation site [posttranslational modification] 885275014525 intermolecular recognition site; other site 885275014526 dimerization interface [polypeptide binding]; other site 885275014527 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 885275014528 DNA binding site [nucleotide binding] 885275014529 sensory histidine kinase CreC; Provisional; Region: PRK11100 885275014530 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 885275014531 dimerization interface [polypeptide binding]; other site 885275014532 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885275014533 dimer interface [polypeptide binding]; other site 885275014534 phosphorylation site [posttranslational modification] 885275014535 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885275014536 ATP binding site [chemical binding]; other site 885275014537 Mg2+ binding site [ion binding]; other site 885275014538 G-X-G motif; other site 885275014539 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 885275014540 two-component response regulator; Provisional; Region: PRK11173 885275014541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885275014542 active site 885275014543 phosphorylation site [posttranslational modification] 885275014544 intermolecular recognition site; other site 885275014545 dimerization interface [polypeptide binding]; other site 885275014546 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 885275014547 DNA binding site [nucleotide binding]